<?xml version="1.0" encoding="UTF-8"?>
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 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PB05</accession>
    <name>V7PB05_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_05630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1314"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB56150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1339" mass="159653" checksum="D77888119359E5ED" modified="2014-02-19" version="1">MNKSINISKAKLKKLNDLFVNATENTDICLNKKKDVSIDPNVTIIPNDNVTKFYDGENNYIQKIDNIEEKENDDELKFVTNKTQSIPIIDPSYIRERNFNEKNKYIDTSFVNNLDKISTDDIDFNHMNNYEKKYYSTYKNEENYSNNQYINATNEYYITKSVEEKIPNTGIPTEHFVYNNDVLQYEDSMKNWTSNSRYLYFIEKEKEKDEKRKETKLKDISLKDSIIPDKYEKMLLKYDFISDKTKMDNLILDVLNNKFEEDTQTYDNTKPKEEIKSDNHEFKQSNEVRKNDNLNAIKKKNKNTKYNRYIISDYLHYYNYFNNDINCSHESGSDSYEYATQKNNNNLISRSIGKREFQNESYDNNKSIYNNEENINIEKITHFIPENFAMNIFLPQEQSIKKHDTYLGDNVEPVLKIKKIRWNKKKIKLEKELLQKYNYVDNYYSHGYCTRITNNLMKKFKKERINIYDIKTKKMNNKAKEDIIEEENLRKMRLNNLLRLSENTIEEQNNYEQEMENKKEESYKTDSYISFDDLDNRSINNLKKKYKMLKKSDNDHERDLKKLKFYLCKKLNKKKYIKKPMKIKKEKTKKEKIKKIIKYSSKTGYNLLAQLQKGEIKEESEEESELSELEEGELFDDQDKNTEDLNSSEYTYSSLTLSFSEYLNIREAYYNDNSYEKIFYPKDPKMNVTYIYDTVDFYHISKGKTLNKRHMLMEMLIFNIKFYERSNFIKEEDLSYSFEINENWKTTIEKKTDDIEELVIDMGNNNENNGIFGLSGDKNKIRIIYNNINQRMLLAKYIKYLNYISSGTIDNAATFFLYETDTLDLRNVQYDKVADSIICLHLKNLKNINNVNIANRSMNVENLCEFLSLPNIKQYSTLNLSKNPLFLDLTFDSKKKDIDCVIDIFKKNVKLNELIIDFVDLSNPLGEYFITNLLLNTSITFLSLINCNIGSDNIKNIINALEHRKVNTIYPINYINIEFNNLTYYDIIFLIKTLCTLNKNFKKLYICGNLVQENIFDVSFAFRRKKKLIEMDKYNKQVPDIFHFDNIYDVKNNLFCNLKGTAELTENSKVSNVTFELYLKYLYIMPPENKLYTIRNITTIKRRYQRFLNIVALHDKKEINIQLNLFSENHVTVFNNLIKKSFHAEMYYNKQVNANKIVNKNILDYFSMRIKNELNFYHYNVTAEEIHYVLDLCKKNFVKNINLSCCYLTNDDILYFNTIKNDSYKINVYNISLNNNLFTSDIQIDQLIKFISNFSIYFKINLNNLSIGANSSTYKLFFSILNDTKSKIVMYAKNYNNSINKTPRTKYSPKTKQYLSVLSYICYFSISYIYYFTTLFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PB06</accession>
    <name>V7PB06_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PB06"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="65"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="300" mass="35290" checksum="66408F2C3DD8959A" modified="2014-02-19" version="1">MENSNVVSNKMEEKSEFSNLSENISEIDNNSISNLKLISPENKKYLINNYMDKIKYIISSNSKPNYYEILNVNINSDYKTIRRSYLYLSKLLEVNKKLPSEYEECYSLIQKSYQILTDKFERFYYDALNNYINDIEIENQRKILEKEGDLIYANKIEELKEIYNKKLNEENLKNGLIIEKALFGNLTLKKKCINNCLNIQPITEEHIKGPFLDYTIILQSKVENSSLLFNDDYSFAYFCDIPKPLIKIPSPFSPVNIIKMKHISNSYTDHIFHFFAKNKLYITLFTTIMLCVQSMKSMCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PB15</accession>
    <name>V7PB15_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_05637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PB15"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="124"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB56165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="174" mass="20233" checksum="F35C9C3AEC9DDF2B" modified="2014-02-19" version="1">MINMKAESNDPFYEAEREVNISVKKLQHMYSNWNSLPDKNSILAKEKYYLMKDEIKYLNKDVDDLENSIDVVKKNTHKFNISNEEIENRTKSLKNIRAILNDVASDLTNTALSPNIYMMDDYNNIAINKQNDDLEVLAESAERLHNAAITINTELKDQQRLLDELENEMDNSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PB27</accession>
    <name>V7PB27_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PB27"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="272" mass="31782" checksum="02A9205D1E70A2FB" modified="2014-02-19" version="1">MQLKIASLMNQNKNEHSLKKNVNFNMPPQTENVDKKKFSTNNSAIAKILNNKLFQRNSCPNISTPNNNNNIDDKTNKEPILGKNPKSFTQSRISNINKMVDENYKKKLIAALQSRKNNYDDTTSIACDNTEKNYSIGTKNMSINKSNYSNYTHMYSDNEENNICIDKFQDNKYPSLVKNKTKNRYFKNKNTLTDDSTCTPDEENSNNELPQKKNTHFFFNFFNLKKKKNRNFKNEDIKKISSNEDKQKAPKDPNNFIPPTKNKRSLKYLFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCQ4</accession>
    <name>V7PCQ4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCQ4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="100" mass="11329" checksum="D74315B3B5E3E15A" modified="2014-02-19" version="1">MINKIKGIFRVLYNYATLLLVYGLIIQASYLCFKYALTFSTKIRIACLISFGFTTFMTLWCHIKCLLKNPGHLNKSGISIMNTNAITNAITNTIMNAIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCS4</accession>
    <name>V7PCS4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_05182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCS4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF26">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN 10, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="6">
        <location>
            <begin position="317"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB56810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="471" mass="55518" checksum="C0A34D24DF21F6DA" modified="2014-02-19" version="1">MQKDIGMKLVGKGNTLTKNVHVYVHKRKLNKSNIFSNKSKENRYKDDKNNLRDNIYFLNNKINNERNASTIYITANPSTSGFGKYVGNYSVRRFSKYSDKNIFNEQKRKCESLLFNFQNFEIKNYLLKLNKGRLQNSNIQKKIKNIIIKFEENYKNILYDKYSFFKKLCKEKSDFYKYRISKINRNNYKTNLNFPINFLNIFISNNNNNKALKELINVGKYRGKLFLNNIPTYYKYGIKNIPYFKAVLMQHYNKSPVTYSLIFLHFFVYFLWINAKPDNMSYSYFSPAPIKSHSFSLLTSEFMYKYFCCSLKSLREKQLYTLVTNIISHNTIQSFLLNTISLFYIGRSLEILINSKNFFFTYIVSGIISSYIQILYQKNSSYGYKNVYVLGASGSISSILATYTFIHPNHKIYLYGVLGLPLALFSSLYFLNELYSIIANKNDNIGHASHLTGMFLGILYYYSYVNKKFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCS8</accession>
    <name>V7PCS8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_05418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCS8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB56572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="149" mass="17241" checksum="D4B77E421CF4DE18" modified="2014-02-19" version="1">MKLLLGITGSIAAIKTGEIVEKLKKECENKNIPIEIKYVATNVAFEKFLNNFKEKVLLDKDEWLWKDRGDDILHIELRKWADLFVICPLDANTLAYISNGACPNLITSICRCWNFKKKILVFPCMNTYMFNHPITKHQLDIILSWGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCT5</accession>
    <name>V7PCT5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAMK/CAMKL/AMPK protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_05620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCT5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000759">
        <property type="entry name" value="CAMK/CAMKL/AMPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="405"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB56138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="910" mass="107171" checksum="4A713BEA5CD4584E" modified="2014-02-19" version="1">MNTDIREKDINNILMHSNVTTTNFNNDPITSTSQKCASKKRICKHIPINKKLNSNKEKFKSYPNNGQDDLGNFPQLLRKFEKIKRKSQIEHSNVHKNVGKSKKNEIYKTNNNYESLQNNPNRKIFQNCRNHYIGGIFNKIEKLKRDNYPIMAPSNFKNNKLAQNMRSNSNKYFKHELNNKNKLTKNHSLKYEYTKKWNNEENKNNDNVQGDEFEKEENNCSNKDGYSRYKKKKKKKNEKYDQKLTLSNIILKKKWINSDTIERIISKNSQPDELVKKNSNENIPKNDTPIVEVSQWKVFPDVISQLDAPIIEPSNFEVPLHRPTKCATSSNFSYKLSEKFSETLSTRLEWDENEILKNGETKKTKSELDGVEEHDYTIRNTSITSAYKQYKIIIIKSNNIEVGNYIIIKNIGKGTFGKVCLGMHTYTYEIVAIKILNKKKLLRIISYDKILREIKIHKKIDHNHICRFYEVHENKNNIYMILEYLGNGDLLTYICKNSNINENIGKRILYQLISAIEYLHKINIVHRDLKPENILLDHNNNIKLIDFGLSTIYSKNNFLQTSCGSPFYTPPEILLGKKYNPELTDVWSLGIILFLLLNKKLPFNHNDINKLFQQIIKGLMQFEPHVSINAKNLIQNMLNVNCKNRYNLNQIKNHIWFSNYNAKKDVYLNCHQVCNLMDCNTCIYIHIIKSSKYYNNFLINRVNKIYNLDKTMILKELKNKEQNCIKTTYYLLLNKMVKILSKTNYLYSHYIFIKKETDSEILISNDDARSITLKDNHEPSNFKPFNNFDNLGTFNFLDLSKIQNHALKEYHTNLMKNRNNGISGDIEQINTHNLLLLQPKEKYNIFQINKTQVPTNCYHYKQTKCRLIKNQRKDLLFSDKRVSINNPKKCIINPDKVLKENIDKKKINKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCU3</accession>
    <name>V7PCU3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RSE1/DDB1/CPSF1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_05201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="863"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="503"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB56830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1405" mass="164826" checksum="CB4120D9FBDDC680" modified="2014-02-19" version="1">MLHKIYFQIPSIIQTIISFKYFKINSVCTSDNEIRHNKIDKKDGYDIKYILINFDENMNLSYNTDKKGILLCLTNLSIFKNQNSNKFHEQYQENQLKRNLLLRECSQRLSQMGGEGEKVGEDGEDDKEDENGGDGENVGEDEDGGEDENGGEDENGGDGEKRPTSSIDVDSYENVIYALKGEEKRRSISINDIKSIQDCLNFFKSFPLIHFNIKDVDKYVKKIYLIHILREKEENWNSNSIIHEIDCIKYVLTKKFWNFCSTSSNNNNNKTWNTKKTSLILNQKSISILRYNKILIQICQNEINIFYYNNTYILLKQILVENQKVIISSKLIKHYLIILNNCNECLIYNINDDILNLMINIIEEFVSIFNSCLLHCLLYDYTDESVNIIDIVKFIDVEKIFYNSSEISKLLNIQSSSMFLKIINKKQKNSDHFIILNNQINNTRCISIIEKNNKQFLSFLNIINNTFNIYDLETKQIIFESNFLLNVPKYVYKTSPPRSKAKKNRMKSEADAEAEAEAEAEAEAEAEAEAEAEAEADKRAQFLSLYKKEEIINILFFKLENYYLLIIFMTGRPIIIYKSFSCSNFFKNLKFKIFIHNYIKPIPSNIHFVNNPDKVSPDKVSPDKVSPDKISPDKIVSTSRHFESNNDGYYIYVCKNDHNKNSNFKNCIVVYPYIDLKKIKINDQDQKIYFYQNILNNYDTDFPILFFSSYKGKLFIHSFDTTQMINSTFCDSHVKKHKSGGDGNYSQTIKGVKKIGKNLFLSFSDNNLSIFSIGTEKYNSIEIIDKNGIKINNMDSVFPFSNKLYLNKKNVYIDNTNSLIFFKSSNLINLKFNDNFISKLFVSYPYISKFAVSQNYYILKKKKNNNNNNNKKKNSDRNSGANNGASDDASGDTTKHAVTFGKVICLIVRIKYDEYYNLKKNLKKRLSYQKDELKNNNLYENEDAVCIPNPILSDCVNNQYTHLIKRFIDDDIETTNNLNDENKKRKNEILIQSIKTKSKYYKLLLLHENSQNIYGYYIFEHSEQIHSISFGQFNNTEYIFISTSLNINERIETQGNIYIIEFSHIFKLYDTNLFIDNLFVNEKKHTNLDSADEKKHTNLDFADEKKLQNKIDHAKNAKLVVYMKKTYNSSVTHILPFYFYSETNKQKYKKISNDEIENKFEIKWNNDKNENKWNDNNYIYSSLLHCTNSKIYIHEIKNNDFIKGAFLDNNFYISDIKIFRNFIIISDLYKGIYINMYSYEEQYDSRRIISISKTFYNHNLNILSCHYIVYNSNICIIAMDVYNNFFIFGHKNKQDIDNLYIYNYFNFNRRILKFINELHQNKHSNSALSISNDGSIHIYHPLNDKAFIFFKHIFKIVKKFIFPNLALNINSDLKPDIFIQSIILNLHKKTDSLLAGNVLFHDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCU7</accession>
    <name>V7PCU7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_05042</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCU7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17748">
        <property type="entry name" value="BRCT_DNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001615">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="146"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="804"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB57244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="864" mass="99092" checksum="C1C40AEB46F8743C" modified="2014-02-19" version="1">MSSKEKNLFSDNSSDEGRKKKRLKKISSNLFDDEDQNMLNNSDAKSVVEIKDESDEELTKGKEQTGNISNTNNQSKKIPLENVDEYFSIIETGSKKVTSNSKRERSHDSDLLEQNRSKKKHISTEDNNILQKNETNVSQNFDYLPFINKKFVLTGVFKTYSRDDLQNKIKEHGGSVMSAVSSRTHYLVHGEYLEDGRLYSEGKKYQKAYELSKQSKSIIKILNEEELLQMFPNQQSNTEQEKNGQEKNGQEKNGQEKNGQEKNGQEKNGPYQSVKHEQEQNMPYQSVKTGQEQSVKNGQEQSVKKAPQVLNQLWVDKYKPTKLEDLVGNTQNVFKLKTWLSSWDDVCIKGLKKQVTKTFRGNFENINAKCALLSGPAGIGKTTTAKIVSMDSGYNVIEFNASDERNKAAVEKISEMATGGYSITSLNNKSLKKTCIIMDEVDGMSSGDKGGSSAILKLIEKTKCPIICICNDRQNSKMRTLANKCYDLKFTTPNKNSVVKRLLEICKNENLMMEPNALELLWESSNGDIRQILNALQLLSKTYKRIQFLDIKKDINNSNKNVQSLANPFEITLKLLNFHESSKLKIREIMDLFFVDYELIPYFISENYTNIFNDNDKSNNPMNKWNTFAQISYDLSLAEKIKYNLKTTMDYSLLPHFSILSCVCPVMRIRSLKSFMQGRINFPSAFGKISTFNKNKRLLNELCFNLSYKLNVYPKYMITSGFLNYIYYKIIVLLQKNNINDSIQLMEQYNITKEMLIENIPSLRLPTQENLYDKLDSKTKASFTRQYNAIHVVKNDPNAVKKSLKSIDKKSSYKNNEDEIDEDMDDFSDSKEDKDDDVLVKAKLDKKNTTKNKLATKPKASKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD17</accession>
    <name>V7PD17_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_05463</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PD17"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="290"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="478"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB56632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="624" mass="73452" checksum="1D2FD1DAF213537E" modified="2014-02-19" version="1">MAWGLINIQKNKIAKVCDCQRIKCFFFCNNNQIYGKFKNASIPKSFKLKQNATEKGCKGCKGCKGYKNYESCKDYKIGNSHLNNLNKTKNVYYAISMNCRYISSNNNEPTSGEHSINEPSSKDSQHNSTINLIKKKKPKQCVDKTENKISKYYNKGTNIFKIVIEFIKKSGSVIKVIIFQPSILKIHYENLKKNIKHTVDWVKTGVLLFLTNMKISKNLIIKRLKGHRLSYSEYKLLIRTINDMFKLIPFSFFVIVPFAEFLLPVVLKIYPNLLPSTFKNNDDNFNNIKKNLYAKQQLSKFLQQLIEEKEKQLNENIGIDSDKKKKILNKFHQQLINKDEEDINPFLNVNDTLKIAKIFKEEFILDKMNLKTLQTICHLLGLKPYSIHYHVVLQLRHHFLRLQREDRELIYEGVDNLKKNTLIEICKDRGMNFNTNENEMKLQVKKWLELASIKEIPYILLLYIRCVVVTHAIMDIKNENDKQNISKFKNENENVKDKNGKDKTIDDKQKLIQEAKEKLVDLKMKEKEIKKNINKETNEDNIIQHKEMKTNINFIKKKNKYMQNELALLNQICNLQHRYRHHLTSHHFNYLTSHHFIISHHFTSHAPFINSILALENSNLRLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD25</accession>
    <name>V7PD25_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PD25"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="819" mass="97556" checksum="C1FE3D5B3F5E7836" modified="2014-02-19" version="1">MSSRLLKKFLKEQNRDEINKINQSVETESLPLKPGPKKKKQIFKYLEESQSDENTSESTTQVEEDEKTILFSKNAQNQNKQKKGGLSKKDTEQHTKQETEENKKKKNKKKKKKKNKDDELEELLNKIGEEQYEKQKQERNIKNPKHPSNSNSNSNINSGEFAKENHELREEVKLWACTHEKYKYCLKLEKNNFDVNIELKRIFGKDFVKENKFVKKSKIKYLKNWLVQDYSTKTIQAPLTMKYVENEFKIEKEKLYLEAENLFYLLLDTHDIQSMNDLIKKYPFHIDTILILAEYYNETNNYEVANQYIKMALLLLQNIFHMNFNIDYINNNHKIYVNPQLYDNKVLFKTLYMHMQSLEYEGCTITSLEIAKLLCKIDLCNDLCGILLRIDGIMLKGNVFEFLVFFSFNFILQNIHYVMPLSRTNEIISDFFFNENDIKNGENCITEKLNPNEEISHNNIPTTNQSTNEISKTQENILKMECKENISSLKRQDEDIFDDEKIIYEQFSQNNDFTKKLPEQDRNNDKLDYLQNTHTKKKYDFQNYEIRLHFILPNFAFSIPLCLYLKNNTNVNYNEINEIKKNDILSSFSYEECKFLIPHFNINFNCYWGNNNVSNLCDKKNISYSLSYSSHLFLIRALLFYPDFVQIFVKYNNFNTSKIVKNTIYDISFKHILSHPPFSDNTLFSNKEEYEIVQKIILAYLEKNNIYYKSEKMITWVHVCSAFIHEMYKDELVAKELDEARKQWHRRIPLLDINKYKGIRVSEFKSRNYLLPDFMMEKTVSHPAPVPNTTSQYYVSLDSNVLVAFFQCLLPWYQVDYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD27</accession>
    <name>V7PD27_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_05468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PD27"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB56642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="389" mass="46158" checksum="CB08C94BF0A09BB9" modified="2014-02-19" version="1">MHSKNVDIEIVYLKIERINISFLTLSGVLTLKLQGVDLRIKPNIHKNASKGIKNKLMKLLKNKEKVHIIDKIKLFSPNGTTDFSSSQKRVQKKILCCSCENYKDIKNMICSYNNYSNIKTYICKDCSILKNKKYGQNLNLLHEQIILKKAFTNYTTDINNITSTTNIPYNNNEIKFMHENIRTSLNNKNIYRDTINGKGNFINSYKQNKNSYSDIKNRHEFVKETYSKLYGNNNEKYVYDTFKNQNYYINNTNIYNNMDMENNNIFRYEDELNKSQNFNFEKNYLTSEHIISNNNFGKKQNIESKKKKTKDNDKRTKICTKFHNSFDHNIYQNSQEIKEEAYKNIDYNIPGKKEGNNCTRNINKLLYRYSNMDNGDYRKIKIDNFFQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD31</accession>
    <name>V7PD31_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_04365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PD31"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB57476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="115" mass="13060" checksum="1E8D0FC34050EE35" modified="2014-02-19" version="1">MLGNGRLEAHCFDGVKRLCHIRGKMRKRVWINSGDIILVSLRDYQDSKADVIAKYTPDEARSLKAHGELPETAKINETDIFDDDGQHGVEFLDDESDEEGQGEMNNDRKLDVEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD32</accession>
    <name>V7PD32_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_05472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912:SF3">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1384"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1644"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1843"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1407"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB56647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2142" mass="254626" checksum="763A6DA727D3DC87" modified="2014-02-19" version="1">MASTNQTNISKYYKNIEYILFEWLYFHYNNVYYNEVKNEQYIFKNKENEYNKNESNLINDDTNSKQLNYMKKNDDNSSGYINNEHSYKNFEKSNFYREEKKKKNIVRENKLKIINIYSLKNLVIILYTIISHIPYFLFFKNKIKVECKNRKDYMHNIDILLIILNEIKLDNLITRQVLIDFNYIHIFLFLNCLYFILPNYLPKYYLDVDDISSYKSDRVLIKEEIVKKKNTIKNKKNIDLHKDKERKRNHINNNDKSVDQNERIILIYNLNDNKCKYTVFLIGCSKYEIDKEYIEIDSHKSEEIKLKIDPNYDKNIFKYDYNINIKFPSFTKKINNIHKKDNLLSHENVNNTIPYQKNTSNFGDYSSISSSSISSSISSSSIDSFQSSLSYDGIKNVEENNYENNFYHNENYTILVLRKESNLFPGDNDEDKFICIKLVETNKSKLKPEIVRNNSNLLVEGKEWNKLNSNLKFEEGKINMKNGSGTNSSKINIMLKNSEIKCFNMRGKIYENKSVEINLINDISKKVNINMNMYHIYIKNLKREEIKKGKFDIDILNNKENVNYKNDINRNINEEKGYKECDVCSLLNLNLKKNLNCDKNYFNCFYIENMKPFISRENEKKTITLHFCPFIEGYYLCFLLFCAKDLKTKCVMSSCKLNCLFYINNIKEEEVIKIDSQLSKFSYQIKLIPINKRFLKCIQFILCYLNKMSNKVFLCYIKNYLNYINKISDQFYIICDKVGKNGIKEKLPSFQKYNYNDFINQINENNLFLDNFYDQIKEKNNYLYEFNINEENMGVYEYNIILMANNKKKYNEDINKSIQLSKYDELEIDENSIYNACNKLYKIIANINKKENNNIINVTFNQNAYLLSKKCVSIYNYTNKNLIYKCSNSEVLDMNKNKIDYKIFNYDEYIEIDKDVESFNFEIRCYSVVEVECSCFIFLTNVENEQDVIKINVKANIVKPYPKDTIHLKILNKMKKAVSIEIYNELDFHCEYKIYSDLPIIFGDQKIEMLPKQKKVYTFFVRSIHIGEFIGCIIFKCFRFLDVNKIKDSRDIIKNDSNITSKNFSLVDSFFWYKLKVTVDLNKPINVLTLESNVGDVLNKEIVLKNNGNKKEEYFLLSYMNEYIEKKKIEIPANDAYVYTIKYAPKIPNYFDNILKHENEEDTKDTNFELDEKKEKGSKYNKTKKSECMKRKDEIKQNENIKFSDISNELSNFYFLQNEEEEIKNEGDCLQKNMTKKLNLEKNEKKIFEELIKYCEKYINVDIKYTSHNIGFFFIYNKNEGVSYYILILLARFRTQLDISNFSSLLSKSCLIHLNFEFSNKNKRYVNKLETDQQKNTSYYYQIGEYIEENNINKNNSYNCIENYKLNNGFEFYNSKIERGADKSSNIKEFDGDENDENGNGNGNGNDGDENDDGDGDMNTEQIVRHNIKGIYLSNKINYSMINCDNKKSGNYILIKYKPTVGTSQECYVIIRSDLFGDFIYFLKGGYIEEKKIKERIIIHNSFCLYNFNINLFNPFSSKIYVKCIIETDRSKNYEYNNMNKINCLKLYKSEKSRNIENGKEKILLNTKYKYFKLLSNEHFKIKKRKNFSIFSTYFCKYAKSIEKLIILLYPINNKKKEKKINQYIIYEYELFFNNTKSDFFLETDRIIADKEEEEEKEEKEEKNLDNIENVCTKQLNYISNEMSKSSSFSFNGVEKDESAENGLEKDESAEDGLEKDGSDEYSLEKDRSAEYSLEETESESYSTIEVGSKRNNHILYLDKLSISDSSDVGIEECYEEGMEINNKFDKNIDGINNKFDKNIDGINNKFDKNIDGINKKEVVYSDGKIFIQSICKIKTSMKIFINKKKIGEMEKYYQTIKELEKKKQEKNIMHRNILLEKSNYKIFFLNLNNLKNSDKIEKNCKDNYGNEVLNNILFNMNENILNNFLYINIVEDKENYLVISLELLANIPFHCNFFIMIKKVEIRENNKNDKLDVRNDEIYQYENDDKILKVKSIKSEKIKEFITVEKNYIFLEIFNYINISKKCINIYIDNNLYSETNLNIFYKNNNDSYFDAYIVGYNQLLDKNNSDEIHNYTIRPKQGILKYNHFNKFIITRTNKINIMAFNSSFLLLIKTENNLFSYIISSHFTPSHELYTEVSHCICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD37</accession>
    <name>V7PD37_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LSM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_05476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PD37"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB56652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10393" checksum="DA96C395FBE07870" modified="2014-02-19" version="1">MIMNESKYSSFKVVVKDNREFLGSIKYLDKHNLFLINCEEHYKGSPTHGNQSYIRDSSDVLIPLNLIKSIGIEKKIFNNCYEEFTKNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD48</accession>
    <name>V7PD48_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PD48"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="184" mass="21886" checksum="159801BA29F63165" modified="2014-02-19" version="1">MTHKHICLILRNEIESLTCNILIRLCNELIWIINSQKNNNDIKKKCIRNIFYCANKLNIGNTESLRLYMIKYFGNKFIENIETDYIILDKNICKLVNKYTFTRQEIRDMKNKLQDEMSIPINNKIKQCFCNFCINPQTSFTFSKLNKHENITSIAQQYSHYAENIYDAEKKEILAEIEKKLILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD51</accession>
    <name>V7PD51_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PD51"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="198" mass="24001" checksum="2C78466EB1860FAB" modified="2014-02-19" version="1">MNDIISKDNQIKSKNFITIYTIRMYLNGFIIGYVFRKEIYKNFYMHKNDNIIFDIIKKNKFSPIYNNYKKSTYISKITLRYKTKNDLFKRLKAYNNNQNYQNYQNYQNYQNTSKTILFHKLPYLKRNFHIPNFFAVRLSFWTCISSTICWYLNKQIDNIAISSTLSGFIASSVKLDNIFFSYNNALYHYVKYHKLQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD52</accession>
    <name>V7PD52_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PD52"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05608">
        <property type="entry name" value="RTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="113" mass="12893" checksum="F2DBDCE4A307F330" modified="2014-02-19" version="1">MSNDFIQDMEINKKENKFPYCVVFTYLPFVSTFIPIIGHIGICTSEGIVHDFSGSYTISVDDMGFGDPMKYWKLDKNKLPLSITDASYDEAIIKADNEFSNRPVHIISILYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD63</accession>
    <name>V7PD63_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_05301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PD63"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB56945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="170" mass="20594" checksum="B2AFC1B3D6EB3101" modified="2014-02-19" version="1">MAHFSNFIQKCQFEGCRYHDFLPHKCEYCELMFCELHKKAQDHVCSKLKHSDLKKVILCEYCNAVIPDEEEEIKWHLIHKCTYIKKATKPKICDKEKCKTVLNDINSYFCKQCKKTFCLPHRYDFAHKCISDNKYKKGFFENIFKKEEHKSDKSYKKNNRKMKKKWCTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>V7PET7</accession>
    <name>V7PET7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_05235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PET7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB56868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="153" mass="18360" checksum="AB85EA17806B4934" modified="2014-02-19" version="1">MIECEHGSERQLIDKLQTKTQENNQENIINKFKNKLVEHHYFIESSNLINYMASFQWIEKKILKYQHKIIQINKIKVEFNKNLLQTLLNCFIIIDHEYSKPSLSKKIIQNYEWNELILYINQNFIDRLTTFNPLLEFEGLFTNTISCNIATKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEV2</accession>
    <name>V7PEV2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_04410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1482"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="917"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1284"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="918"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB57540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1509" mass="174860" checksum="F46751FFB8A6351D" modified="2014-02-19" version="1">MKNNMNIPNNINNNMNNNYNNENYNNVNNNSRNLINNNLNIPAGLNNMANNMNDRSNNMKNFPNGVNGLNKNIGNINNINKMHNPIGKMHGHINNIPNNMGTMNSNLKHGVQNIINGMPTGINNMHSNLNNIPDNIKNMANAMKPMPNNINDIRVNANYSMNNMNTNVNPNNNVNIPNDMKHMIRVNNSDITSNVKFNTMMNNNNNSHFVSPDNSNRNMFYVNDMKNVDNNVINMHNKRNNNAKEKKNNIPQFREKEYLENVGHRDKYLLNKNETDKIYLQNKQLNNMNQGNIPNINNNNTRNNNTGGISRMINNNAQNTININSNNNINSVTNIGNNNDNNNNNNILQRNMKNLENGGMHNPLNINQMNAMNLNKTFNFSSNDPHNFNINSAADNKMSNKFKDSNYNNINKNINIPFNEESKYDPYNLGNNINRNNGNNGIVVEKNMNNAEHSFSKQHNNGMFDIKAHSGKDNFGGIKNMNDDKNIRYNSKLNEMNNANKVGKDIINLSASNIQKLNEKNQKANGNSNTNFMGNNLPKSMENADLYKLQMNYDKLNSNDPNNYINKMDNYNDFIKENNKGKYISGNKYNANANTKGDQSKNKTQKMENELINKKFNPINNNNNNENAPNHHMNENMIYDEMKKMNNTSFEKMVGNDMFMFNGNRSLEKGINQMVNMQGFRDIKNIHNINNYRMANDNDPRSNEKNNNMFHNQRPNFEGCNGTENLKGTGNELEEKKRKKKREKKSEMEKNEKNEKKGLNRDENLDDKKTINQLIEHNSFMHNLNENNESSEVGQNIKNNLFNDISKNYMQGQNIGNDEKELNIDSNLNENMKKENYAYIRKQNIFENYENMNNLKNAFLEGDQNMLNNANIFNKINFKFQKKKSDDSYENASMFPNDQNDEDKKLMVLSRLFGNVIGENGNNNNNNNDDDNNMQTQNENNMNNSGKLPNIRKMNSNALELELYKNMPLDTMLNKLNLDKNILNILKDKINNINRNINVNICSTSMETPEEPIKMENIDLLKLINLFDEFLNWSENNLYQIKLQLYNIAFCLLLELYILILANKFSMLIDFKNKYLKNFEAYHPVIKFLSNCVSLNQIFEISILRFKEKNAKHIAYMNKLGKASLMHYLSVYGSIPLYNLIMTKIKIIEIDDANKNFNFFHEFISMNFLYNGNLNVPVQWNLPSIYFIKDVSETQNDDSIKCTKEKEENVYIPNENSDAYYYYKYIIKMQAENRLKVTKNRMPSMLYYCLNNCTDMTCAEISSFDGSLVATAHSNNIIKLWNIKKSQMNKIKEKQKDMEIYNNENVDEINNYSNIQENKPDSIHLDDQDENGIAKLYGNMYNISSLCFGETNKILLSGNLNGDIYLYSTISNRNYVKYSGGHTPIWSIDTAFLGYFFCTSEDDGNLRIYSTNKTYPLVTYKYNCTSNICKYHYNNTIVASGYYDNYVHLYDIRVNSFIKRFKNNYPSNNGVTSLSFSKNGRLLSFGGIISLILSICRFFYNLFYIYKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEV9</accession>
    <name>V7PEV9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_04412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEV9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB57545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="505" mass="59258" checksum="750B4724F05C99AE" modified="2014-02-19" version="1">MDLSDEDDIDIDEILKQAENIECVDEDSIKKLATVLKKKKNINERDRIEHPDKPEKWVASEVDLDEILVNIKNLSVCTNLYKSMIESDIFGDIINLLNHPNNDIVIEVIDIIKEITNPSNIYELNKSVNLMLIDYLNKNKLNHFIINTLDKINEEESEEYYNAISSILNIFENIFELENNLQNDLLTNSKLLFFLLKRINNEIKSDDQNSLYASEILVLLILRINQFAQNVYNDFYYTISIFNFILKYISKYKDKDPPNINKKEILLNCFQALGNLLLLNENKKIFESANGLELMLKLLSERKFLCFPSLKIFAIVLTSKDVCNKFVELSGLKYLFCLFMLRTLNKSKTNTLEFEENIITIISNLCIYCTGTSLGRVLNKFGEKKCEKIIRLLEIRQKYSDIIINEKKKEKDKLLINKNLQKLNIQIDDDCKKNLEYIELCDKGYLTYQLTDVILISLFFMNNSYISNNIFIHLYTRNIDIQSIYENILGKLVESQCYFEYRFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEZ6</accession>
    <name>V7PEZ6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635806">
        <property type="protein sequence ID" value="ETB57327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEZ6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27443" checksum="DF81D47731B9BA15" modified="2014-02-19" version="1">MCTDTEEAKKAEEIMKEAVTLLQQHAQSEEDYNLYHKYDEEATVYFKKHEDTDIGKLELKIRNPDHYNDIVKILWDPNGAKHFDGNFINGKLVRVYNPNLVIVQLRSRSLVGLAQEYLYALAYKVEVSENETIIVHASADIYDHNDTYEYSYRNTILESANSFQTEIDPEDDIVNGEIIKTYINLSGCIIKKEDEYVNLTCVNSIDVESPNMEDLILKVVKSIKMATISNLKNTFENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF61</accession>
    <name>V7PF61_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_04250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF61"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="209"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB58186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="623" mass="73933" checksum="775A3992661F9C38" modified="2014-02-19" version="1">MKNENIKFSLSNLYGQFDRDKNKSNRICNKTGTSILPINNHKIYKNNKNNSVSMIHNFEINKTDNSSNNNPSYIENNINDNLEKDIEGSNKNKSKKTTNEKGKNANNKKGISLNYIVNYNRYEPKISILKKSICISTAKNIKNKRNNNQTSSNISNNNNNKKKQYINCNFRYYVLEKKYLTNSLDGDNIEWKHIEKVDYIIYDDTNLACPICLENNIISPRITKCRHIFCFLCILKYFIDEGKNQAWKKCPICFEIINENDLRCVKFQYVKRYDINDKISMCLLFTHNKKIDIKCEKLYFNKNFKVTNNNFIKNKKNMDFKDIVNLDTTIQNLYSFSQNNSEKILKLNLNLGVQFCKIYYLYNPLSLLLKDLKILYFIRENNKNKFFISDQDIIQKAITNIKFRIAEYMSIPIEKLDSNLLYIDEGTELDLENLADSFYLYNNLAQEVYDSIEQIKKEMIIDSLGMPTKKGVSSDRRESTDSEKNNNENEIYFYQSIDGQCIFLDPFVLKLILFEYNNDMDKIPKFLYNKHITYIESFELTEKTKKKYTFLSCLPLGINVSFATLNIDDVISNRTQTHFAVFIDHSFIFIYFHHRYLFHLFFYLIFTNYRRKYQSEIKRIITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF79</accession>
    <name>V7PF79_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Maestro/Maestro-like HEAT-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF79"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314:SF0">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="1">
        <location>
            <begin position="131"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="467" mass="52946" checksum="2679B49BBE4183D1" modified="2014-02-19" version="1">MQKIINGYKKCRLNEKLEKSRIQFTQSISDLCLKPHNIELLVNTDIINLLRPLILDKVPIVQQNATVILAKLASYSEEVALTILQNDVLPHLIYCLKHENKNYRKNCAYTLKCLANHNSKLANIVAEENCIDYLMDCLDEYDLRVKQSCINALCAIIKNDLELSNNVVDKGIIPLLILCLQEKDNNLIKSSLNMLSELCKHSDEIAKNVVDNNVLPNLIKFLDNNDNYIKKNACNCLSQIAKHKEELTELMIENDIFPKILYLLKDNDDIVKKNCANCLKEMSKHNEDICKIIVRAGALPLLCECIEQSSKDTIKLPAILCLGFISSFSESLSLNIILSNTIPILKKSMIEETEDYIKSACVWTVGNIGKHSTEHAKKLADENILIILVNLYNSNESSDDLKKKVKIALKGIIQKVTDLEALHPVFLKSPLKLAKYSIFQFSKILPKNPSYKKSFIKSGCLKYLQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF89</accession>
    <name>V7PF89_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF89"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10567" checksum="B0DB2D8633F37735" modified="2014-02-19" version="1">MKSKIINSLTTLFNNELKENLLKSRNREEISNTVSNLIKNNIKGITANTYKVVIEILLNENKGQGINVNTRLFYNNQSDFFFKKFIENVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF90</accession>
    <name>V7PF90_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF90"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="306" mass="35469" checksum="9BD3C1EF30C20260" modified="2014-02-19" version="1">MSRVCIITGGTGLLGNSFREVVKNENPNFIESENEIIVNSNDKNVIKKYVFLSSKMCNLKNYDDTKNFFEKNKFTDIIHFAAHVGGLYANKNNNLQFLLNNLDINLNIVKICHKYSITRGIFALSTCIFPEKCDLPLIEENVHDGRCHLSNEGYSTSKRVLEILVRCYREKYNYQWMCIIPTNIYGKYDNFNLENGHVIPSIIHKIYLAKVNNTDVKLMGNGSAIRQFIYNRDISNILYYILNTYYSQNLTIIKNNIFNVIFSTNLPSNELSIKELANKIKHYMKFNNEILFDDTQDNGIHKKVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF93</accession>
    <name>V7PF93_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF93"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="61" mass="7471" checksum="9C863FB26476202A" modified="2014-02-19" version="1">MYSNYIKLFIFVYDYLLTQIRDAKSIYKNILQSCFHQYDNDNIVKKWDLWGSFIVYVTLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF96</accession>
    <name>V7PF96_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_04334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF96"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="725"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB57442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="820" mass="93767" checksum="6269FD43E62A5198" modified="2014-02-19" version="1">MLNSINSDKPESGDKTDMENNVNDREVNDNNITNNKLNNNENFDNVSKNGFINDKINVEKTNSDSSNNDISIKRISENENDQGGGENDKCGSEHDKCGDYNLRNKDIQHILDNSLECDNIVIKNVEDSNNKDIEKSEILENNQIQKNITHYTNNNNDNNKFCKGEDAIEIENINTSYKNIYSESIDDSHKDEFNYKEISCIKIDNSDFNKREQYDEKNGSISPIKMNNNSDKSDDLNNYNLENNELDKNADNFDEKKEKNNSKNCLNSSNDKNNCNNNNFECNNDNFEYNNGNDLNTVCTNASGILDINNKTNDSDIIMKNNDNAEIGVNKIKEMEEEKNKCSNNENDAMSNKENINEIKNGEDDNIVFNNNNSLQIFKEKENKIKENYEIASEDNAETDAKLYECKEVSEKETNEKNINNDNGDVDVDKVIDGEGSGNTQKEEKELNNCSFEENKKYEDGCEDGCEDGREDGCEKPNVENDNYDDINKKRKHISSCDESRKDRKLSSQKEHEEIENEDINKYGNDIDSNAINTTFCKNNNTNIIKYVNSVEEIISSNSINGDSKNNSNSSALNLKIENDEGNGANDTNGAYFSDMKISNAEENHNYNDLILKQENKDSLNKEEKNDINNIGNNCKDECSNKSQDSNIEKNDGINDGINDGKNDSEHNLENLKDCDEKSRDNDDEYEDEQNENMSDNNYSDDEKTNLDNCNTNDKKKNKNDSETLLPIANISRIMKRILPAKAKVAKESKDIIREYVTEFIQFLTSEASDRCLNEKRKTINGEDILFSMEKLGFNDYVEPLSEYLNKWKQVGQKTQKKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGY4</accession>
    <name>V7PGY4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Condensin complex subunit 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1641"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1643"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1707" mass="201996" checksum="8099A6BCD0F1EC03" modified="2014-02-19" version="1">MEKCNKRKLKEGVSNKNGNEHAGEKKQKTKIENKAINEKKLYNNLQLHNNILIKFIKENEEKYGKLEKDENMYRKLKAKFLSLNISSVSIEHYDSFDYFEKNKIDFLLPELDNIVNSSNIDVLKGLSDVSFYPNYNETIRKRIVEWLVKERNKDENTKDDAEHTSISYLSSMNILLTYLIYKNDNYSNYACLICLNMLKWMHIERKKQMFRLFTLKGILKRFLLCAHYLNDKEIMKIKKMENDQSISEDIGVLKNIFMLLYESIDYLDISNLVNINSKNCIFELIKFYIELLKYPLIHSVHILCINYLIKIVIKCYDIRFEYNINVELYDIGPHVNIFVKIVNLIFAKILSILKDIKNSENVYYIEEINNINNLIALLFTNILNSCIRIIIPQVLYNDKQKQKYLLNNEMTRTTKINKIKDDELDAEDKIVLNACNPVFSFIEIFIINNSDKYEKTVFTDLIKIIINNCRKIEKKYNVMKIIHDEFMLHIKGEDNKKNGDKYLDKNYLKTKKISKKRLESTASFKISDECNSSVYSETEGEDEEEEEDEEKGREDGKSEMGDNQTNGYESEKETNKYCPVSKIKNKTKSTLEIDNKKYCIVYESVMIRYLNLLLKYMNCEKHQIRNMILDLFLILLKKKKTNKNENIYEKLFRLFLERLEDPNIVVKSKALSILVTLTNKKHHNNNLVRNFIYNKRKEKINMYKIISSNIFSHRSNIRKLTIQYIEVIFETLISQKLNYKIFLIFISNYLYSLSFDSILSVRRQVLLTVNILFLMASNDEYIGKLWITIILSAITDTEETIKDEAISIFINTFMKASINCSMFNTNEKKINQVLEENGMTYFKALTTFSHELKTKKDDYKNTKSDVEVNPIVKNGSITDSVTSDTNQRKYSNNIIKNKEGLEKEREECDKNNDGVILLIEIWEKYFESNMDNYFLTLLKMMTKYDLLNFNLILLCLTQKKNNVLEEFIKGINIFIYNLRYFSIRTWNTFIFDFIIELSKEYQNSINFESILFLLSRCYKIYLMNEKKNINKSNIIDKNIMAEKKIENIKENPEINNTIKTEFLFDSILTDQELANEKKSCPNGILKNIMLKLFTIISNLLNNENNEVNENFLEIIENTIFNFNCPMCFIYIILNILIKKKKNVNQFIDKLKNKIHFFFEKIEIIPYNNVFCNILVTFIFLINHYKKQDTEFLTMASEKLKIVYENVCKDKSAGSNETAIGGEDSDNLNHLGENIIMVKNCIYMAQCVLIIDKDMMNKSDFFLTLEKDLKNSNTCMNILNNLIILTYYMIKNFGSSCNKFVFNLLRFFKHENSFIRYLSFYMLSKLISEDYVKFNNQFFFGFLYLLADKNEIIRKQSLSVFKHIVLIYNKSNLINYMIDFIFVLNNFYSIKLSKHLIHIGNHFEIKNPEDRYKIYCLLIENLTNSEKFSFQQKLINEYLIQYVYDYDNYYFSDEHAKEKKGDDGINTRAKHNNIIPINDEGNEGSVLKDVLLILSSRLMKIKIKKDFAKLEEKNKNIKIKNVESSVKVLNDLMKNILKKNTLPILLSLRAIMLKTKSFFFKYINNLIIYLCIDYKDSLEELILEAHTRNEIFSDIQHFVYTDVIHSVHNNNDIFNKNSNINIDINFLELSQNQMIEHNLEKNMHNKNIRKKGNIHKKKNDDNSDDTSDNSDRSSDYEEVSNVLHSIHNRHQLSNNIKINKKTKKNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGZ4</accession>
    <name>V7PGZ4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fam-a protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGZ4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764036" description="Fam-a protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="25344" checksum="1F48B14F57A37B94" modified="2014-02-19" version="1">MNKFCIQIVLFLLSISVCVNTKSIVANLDPTKDTESKSTKCYSTNDDSDEIYEKNKHLLCINPEETINAEKLMNDAVSKLEYHATSRYGYIFDGEYRPYNMLFYKKKYRNHTVVEKVEYTINDPNKYNELIKRFWDPDSNNFLYERSDKRKIVRVYSPNLVIIQQRWKKWPWSREKYFYVLAAKFEVRKTFLVYFIINHIFRIIQIHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJA1</accession>
    <name>V7PJA1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJA1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="408" mass="48682" checksum="F25E189EB84C6BA1" modified="2014-02-19" version="1">MEEKLIEMENIKSEMEEKDKAILNLSEKLLIMSNKYDILVKEGKLKDEEIKHIKNKKKYKKQATDEYIATMKKQNDEFKNDNDAIHEKYDQLLKQYDTLTKNYKLLEDELNKNINELDLEKTKKMNEYDEIVAVKMLNMDKELRQKRHTGNDEENSLKLELKYKDMIIKKLIVKKEKEKILEKKEFGNKEDTNNDIDEQIINYEKKVNELHQKCIDSQSDQAQLKNKITKYSNIIDDLKKENNELLEVISTLREYINTTYKEDTDIHQYDDLINNLLKENVTLNEEISKQKKKNIADVYYYNKELQMLQNDKMKIIEKFDIANDSVPHLYEPLNVTLHEKKGDEKNEKKKNCYKNSHGTIIQELSNNSKKDTNLIKGNSDSPKDLTINEDWAHIYMQDYMKNVETRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJA6</accession>
    <name>V7PJA6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJA6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="362"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="902" mass="106628" checksum="187EFC0D8C0AED06" modified="2014-02-19" version="1">MKEIDKASGIKEIKRILPSFCNNRKKKEYLYRDLSQTNKLCLYGARELDEKFIYNPYKKMKSFKFYKNIDKNLRVNKIDELIERFEKNMKNEKIQVYNFDKKIEKYTDLKKMLLKSRKSITKFELDENGNVKTVTELFQKYEKKKKKNIITFDGYNDNFIKIKKLSNLDELKKVKKKLSEKNNPVLLYSDQYKTSNMKQNKNNDSILNTNLCIDVNKKFELVENSTKDINYISPEKNFKSKTNSMMHCHNNYKNIDKSSKRKDWDKYIANLNFYMQNINGVKFVNYYDDDEIIKHILKENEQKTNKTKLDILNNKTLKHNNVSLHRCGGGLYEYTNQNKINNFQKKNMDIYSESYMNKYEILSKIYNLNQNKKNEIVKYNEEKKNSKQINAFQNNQNRQINNIKKLKKNYNDKNKMCQKNCGCGNNQISNIFLSNCFEKKRQVSEKNEKLKVMSVHKKTPKKKSEPILEKKKYQQSQPFKLDSGNDKIRDTVQLESKIKYQNEKIRNPVQLESKIKYQSGNTIEIKEKEAKLNCENMHLMDKENRTYSIIKIASIISKIDKSKNSIYNENEPNENKTNIKIEGFIFNEHLKDITIKSYNINNKSSKNCIKYISNNRNDNKIIDEDTEEQQTDFIVSKEAKEDSTNDESIKRDEDESIKRDEVESIKRDEDESIKRDEVESIKRDEDESIKKEENAGEGEGGVIKKKTSSLSSSLRKDVNESDSINLSDFMKRENSNKEDNIDDSYGSIETVSRDIQIENDKEETINNYLKCGFFAHVHIILSDTNIITRKCKIFYDNKTKKLGILRNKKIFKIDVSKLMIQEIPSSKPDLAIIKIIIPQNNCRLLIVESNDFFGLQALGDKIGWSPDINGENELEITRKDQEDKLNKNHFLMKYFYKDMERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJA8</accession>
    <name>V7PJA8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJA8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="223" mass="26258" checksum="48401CDCC0B12336" modified="2014-02-19" version="1">MNFIEYDESYKSYIERISTDGTWGGQLELQAVGEIFNINILIYQENGSILEIKINSNDSNCIQLHYTSNEHYNSVRFINQALENQLMSIKDLKEMIYTKEENDSIKTLYETTENELSDELEEIEGNNLRKENKIYDNLYKKGDFFKISNENEDIYEANFNLTENNKHKLNCINISQNNCNKIKLKKMRSRSMPNVNDNFLYFFDKNGLDEQIESDSTIDLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJA9</accession>
    <name>V7PJA9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_04009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJA9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053300">
        <property type="entry name" value="Homeobox-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45795">
        <property type="entry name" value="EARLY GAMETOCYTE ENRICHED PHOSPHOPROTEIN EGXP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45795:SF1">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="779"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="4">
        <location>
            <begin position="347"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="721"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB58403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="103519" checksum="4744711920837041" modified="2014-02-19" version="1">MHVSDKLNEIFYWAKEELSEIINDIELEKGEEKIGEIYKKIKNTIKIINDSNSLGNTHNNIERRIIKNENIINWDDLNFCLFYYINIYKKIYENLYIEEEDFFCKFDTYNYFVKKNFQINLAYHPLIYSIDSSYFNFLFSFIFDGYKKGDKKLSIALGKTLSLEKNEDNNNGYSISDQNKQHNQNGEKQTCEDTKKKKNQKKNQKKNQKKNQKKNQKKISQNKITYILNDDVEYKTNFISTNETNFELSEKFTKTGDIYKYIENTSDSLYNFGYKKVIYDESRDVFSNPQNNKHHFQYPNDLENEDESNIKNNGNNFCDKNKTINNNEHGKYQKIDITQAYNYSVKNKTYMIDKELNKKIKIYNGDIANIESQGIILYANNNYKYSKSICENLYSSNLMKLEEEEKYEIRTKKSGEVYLTNSYDNIHKYILHVMLPKYNSKFILATHNTMNLCVHEILYACFEKKIQSISIPIVCFSLFFPINIFLITLLKSLRSLLLIPQFYNTIKNIIFVTNSNAIYFFLLKYISIFFPRTEQERFLSTNIAIIGNKIGSIDVQNRNITIFKSLRKVRKKRRKKKTEKKNREKKNREKKNRDQNEYDDQVYTNLSEKSEMKKEKYILDSDEELSYDCSDCSDCSDCSDCSDCSDCSDCSDCSDCSDCSDCSDCSGSSTSEIFKEADTEFLNIKTQNESQKNFLKLTQINRNDEDMNLECYLRLSYNYNKKEKFEELKKMNFIYEYGIDEFGRNIIIINFCNFPLIYNYNLLYFYLIYYFNTFMRNQFILLFIFSESILSNITNILSLFKDIFQVIQEFLKNIKIIYFFNYSFVFKFFIYVLYPFIPPDIYENIVYLNDDMELSKYFDVRKVLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJC7</accession>
    <name>V7PJC7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJC7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="161" mass="19358" checksum="6D02FF2FA333500A" modified="2014-02-19" version="1">MWKSNYYFLNSYKNYTNVLACLSKRYFASNTDNKLILNKKKDTYKYYDDKLREDITPVNLVKSLPTLNHYVSILDMTKFSIKYILSYRFFFIYMARTTFQAVRPLMAFCVFGEMMKLVLATMTSGVFAFFFSFVLAFEVLYFFLQCYISYTFLTMFFDVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLA3</accession>
    <name>V7PLA3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="878"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="920"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1400"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1619"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1712"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1778"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1985"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1939"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2118"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="878"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1405"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1635"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1712"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1735"/>
            <end position="1749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2435" mass="288675" checksum="2A71E8140A19EFDF" modified="2014-02-19" version="1">MNLFSKTGINTNNINFCESYYSKNANKNNNDDINSSMDLSDNSTIKKYNGFGRDDKNNVSDGDVQSENGYYSNPNLYNSVKNFYDNLSNKNKEGIENAENIENSYFGFLNKNEYNGDNYDNFPVEEYISNIEKKAIPDFKQYLKECLNDPMENEYRNDYGSFDLFGINKTQAPLKKINLFENEKNEEIYTEEDYEELERAKKTKRGRRRKNTKPNKSKSRKNEDFIDDQIAEESWKNPNSNESKFIDDEIIAKKKSILEDTRGNYIYNEDNDDLEYNDKNYYYKKYLINNIFSNISKIVSNNKHEEVYEENDDDITNFISSKNINNNNEKISEAFPSHKNLNSLQDFENSYKQNVGNRNSRYNKNYYVIKEENNGDSNSSNNENNIRDNYNNYTNYNDDCNSASKNPMDNSQKFSDDNKNEYTNIKNYYEYKKSFDKINDDICVDYDVNDIKKANYVHAPSSATSISKTRTNTNNTSNDDLNNNMSNEDILNGENCYNKHEKMLNSYICDKHINSNDINNFCNNNHCLSIRTNSNEIIGNKENVENYYSMMQHISKNKNQYTSDSDDNSNNYYLLKTKKNNIDTENCSINDKFITKDNNDIDNNFPKNIQINSFYNKLDRDNNSRNIINNQPENFYNYMFGNSSNNVNSDTDINSAIKDSNIDNAIENNVNNNLNNKISSNYFLRTHIRNKNGQNNTDNYPHHEIQTPNTNITNSSQICDAHYDILKNYSKTHNYDINMKHYNESNENVYSYCRDDDDNIIKKNQNTLYKIWEEEDDEPQQGEDEMDEEHENDIDHYNNMHISSRYNKYLHNSNMLNRKVPHMNSESMAFPFLKYENMNNKIMGNKPIRIPNLHNLNNTHKHHRYNIINQNSDNIYPNYSDNNNISSNFSNDEQSSEQKKKKNENNILQNMGMHILKNNGINIEDDSDDNISSNNFEDNYPSEGGENNLIKNYLGAHSKDNYIDKKLQLILEEKKTNRGIENQLISMPINNIYNIRNKKNEEVYDYYMNNSDTEKKKFKNTLENRNYSNEIAKARAFESLPSGVALSLPNGWINRQKLSVSKKIEIVKKNENNNDRKVIHNLSNIVPNKYFEYFNNSFLQKNNNFCLHHLKLFNLNKLNENKKLKEQNLLNINNNNNNNIINNNYNSIGNHINKNICENKRNTLDNRRNNIKNISSDDNNGESQFINLKKNINKINSDKYFNFIANFKRPEYVCDKHKMMLENFNKNAFNKHELNMPAEINRYNHPDGYIMNENKIDNLESKEKLISNLRNEKYFYNYDLSNEEDEQNEYENDIDDSYIGGMRKRNKNEHFQDHNMFNRTFVLPKRRIIHSDLVHHFNKNKLEEMHEENNQYYMYNTYNLNKNKGRKKNSFPVANNYNCNIKDEYNGNNIKQISENDDKIASIGNNNENNNNEDNNVENNNKYYDDYYNTDDNEDDEYNNSSLCNKNELEKISQIENIISRKMRSKKNNDPNNCLNEPYDDDESELYNNIEFDRIKIDNILAGTINLEDKNENLINNILELERRKYTINCIIDTLRKENKTEYKIDSKTELKNKINPSIYELYSDKSNYNIYNTKMCVNYFLDEKMHSPENKEFIQKFFVEKNTKNVYFVQVFKNKNKGRKNNKESSRVSAKLDNNSEIHNDNSENKNMNINQVYGEEKTPVFQHSDKIFEDNYNTFVNNKLNEKSFSTFPSNTCSEDTKNPSVDFSEMLDKNEDEEKRDENDANCGIENNNANQEKKKEEMENKRETNENNNSKNKSEYFNYQLGLIIEKFYKFNKDNKNKDNKNKENKKKDNCEVDKKETEEDEKKKTPRNENDQAFFDEYKIYIEQNKQIETNEVGCVEIKDTQKIQIDRNRDDIEGEKVENNNYGDEKKNILDQETIVQNFGEANEFEMVQTSKEKKKDEENYQENNFSLEEKININAKIGEIDEIDEIDEIDEIEDIREYKRELNEDNIEIEKNKLKDLSIQPNLYGITKNETNYMLFEDEGVDDDDDDDDEEEDDEDEEYEEEDEEEEENKTIIEEMDNIEAYNKINDSDQTKKNSTEQEHALKTENNTDCDKYSINIIDQKNVIEDTMKSDINKQNISLFDRNNILFKKEDNITERKEENDEFKNSIDINIDNLEKDKRKMEEFVNNFQENQNKTMNDLKIKAENELEYSENSNMNNENKDYNNEYAHNLDKFEKTNELNNYRNEASLMNYKNEENNDIKNIQNYNNNNTENGNFKGNDNICYNNNHNDANQNNTINHENMNIELDIKNILNNDNNIFKNINGKNIFIKDMVNENNQYAHDYCDIEDNVKYKMLDQSKKDKIEIIKTKIKKNKKLTKDDFKLLSEVLHHKFLLNEISAIGNYKVNYKNSYGILELEEYKLQKEMQSKTCDCLSIGLTTHEREFLHEFQLFMPDVNIMDDKNILYILRHSKDEQKCIFMSFLEENKIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLB2</accession>
    <name>V7PLB2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_03151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLB2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="684"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB59750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="712" mass="84504" checksum="4956862A2E41F1FE" modified="2014-02-19" version="1">MIDNSENHASGYEMLIEMPNTTISSNNNNEERKYYEIYGNNKINDKDIYDNSKDRNEGEFEFGSPVNYTIGNKNSSEKYCYNINEKKKIETDIKYCGYFFISLIFLLFFILYYIYYGNYSRILYGTNYNGLICGKDLKSFKYLYYPLSPKTSKLEILNKYPKCLESCPTSDFSNKNKTDEDNLYGEKKKKNFFEENFFFPFKNNGDKNKGKIIDKNGNIETSVIYTDYTKGPNNNLYVEYLLNSKYYDTVNIMNICYPRDKMLREKVINVVFTNRYKIFVNLFSLHNSFFFVFLFIIVSILLSFLYIASLYYFPKFTFYIFIIFYLISIFFIPIYFVHNHLYLIFDPIKGSFFSYHYLISILTSFIMIIHAVISLIIFYIYKNTYKYTSKLIAITLKFIHDISNIIYAPIIISFVSILFFCVWIYLYVQIITSGMSYDQKLDLDLDSNGSSKILSLQKMFYYFKSSYLFSILWVCIYFFICEMLQSLNQFTICHLGTVWYFSDKKKSECNQNVVEEMKTIMKYHFGTIVLSSFINLATKHLRVLFFWINKTLSLPFFFNELIYNIKERFHFILNPMSKIVDMYTTSAYCEMSMTLYPYVTSCHISSKKLTNSTSPAAALHGISYITNIIFPGFTTMIITFFAFNIFNNFQTYNNIFSPRYIPNPFFSALVIKKKEAKLGFTHGMLLFCFVLFCTQLQKRLFIFFICFLFNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLB9</accession>
    <name>V7PLB9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_02679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLB9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="75"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB60386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="235" mass="27919" checksum="4E76267DF26338F3" modified="2014-02-19" version="1">MNALTIRLKIKYPHLSISIIEKIYLKELNKKLKNIQIIHIQCVPNNFDARLNCIQRTYVYFFINKNYNIAKMNEAAKIFLGEHDFSNFCKKRKNNTSFIRTIHKFEIKNIDQNFYYFKIKGTSFLYNQIRHMVAALFLVGKGQLDEQDIKTMLENNSIKNKNYKIADECGLLLYSFKFSDINFNFNVDNKIFLNVMNKYIQTTILVVSLCYPLKIKKPSENFFENINDETKEILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLC5</accession>
    <name>V7PLC5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLC5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="522" mass="62192" checksum="6B9D021CF7F1E1F1" modified="2014-02-19" version="1">MDKPDIEYLNIPQKIKKKLYESNLNTVEKISTYYLEDLEFEEIELIQDEIFKYHVNDLGINNTEEDERPNSLIKNKIIANDFYSFSDVEHYCGNKEISDDSDNSESDFSDRSKISISSYSSSNSYHYKNSEKNVKENIKKFNNSILKSCTESWISKKEDVENEKKNYYCVENQLEKYFLIYSNFMKKQLKIRKTINTNCISLNKLLHNGIENSQIYFFYGNNAKMNKIILINLLYNFIYPFGNNNMSTHSVVYIYFSYIFDVTVIKNIISEKLNHEKKNPKQKSDFFNNFYILRIQNFNEIISFLLQLKKNYFTKNKSENDNRLNNITCIGISIIIFDYVQNEISDTSRGTNIYDNKKEEPQEINNTLTYNEDKIYKNINIDNEPYNKNTNYVSRKNKQYATTLQKNINNNQDYYSEQSSDLSSYNYYENEDQKYSEYELGNNIKIDDNNNNNIKDIEKSEPIKIPFSCSKHNKFDFIIEIKIVNKIRDRYIIRFTILKSRNNIKHSYSYCSIQKYVLTDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLD4</accession>
    <name>V7PLD4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLD4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000012">
        <property type="entry name" value="Translation initiation factor SUI1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="748"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="832" mass="96229" checksum="0036C4E3FE104CAB" modified="2014-02-19" version="1">MFKNKITLSNKNFLGNKDRKKLAIILKSTFNIENDEEINELLDKEDASICKVQKKKITIYFSKNNPVLVSINNLIFPTVYTLWKFPRMIPCFVIYPPASEFLLRGADLMIPGICKNIDDLDKLKPGAIWGVRVFNNPYIFAVGECCVEYNNNMKDLYTSKGKCLKLVHTFTDELWKLGSLDIPDISFKNKIIDSVENIVDDFSEFKIYGENNKGAKKKNNNNIKVEEKKKEKTDEKGKFGWSSDSDTSEAKKSDTEKVAEKENEKTYKGSSNEKYLANFYKHFDIILKNKNKEKNSQDELKLKNSNTGTTIIASNNNCDKKEYIHDLNSMNNGINLSKENYMNKEDNWENLEESIASADNNGDNNGDNNDDDDNDDDNNDNSALSETENEGFKTEREGHIFSGGENCVSEEKDIISEQGESHKNLKNKKQRNPKNKNVGKKKDKHEHNEDQYSSNDENGGENKTNKYDIHNNKNYNNIFELKTEQQDKLLLYLFLESIYYITDDSLPIDASGIYSKMTKEFSYIHKNKVFLEDLENDNVCYEIINKINKKEINILLDVKKSSYKKLIKFIQHCSKIKLIKIKENRNIVSIVNINKEHPLFSSYKFMDINEKKKCDNENVKNENTTSNSKGAQVLEFYMPSTKTLNIFKHINKKTDKNTYFTIKELRELFHTYITLNNLQSDKDKSLIKINNDIQAFLSSEKYDNMLPYDIAVNKFISLQQPCYAIVKPNANFDIDPIKIIKGVCPSIHIYSVARMKGKKYVTHITNLYLFYVDLQKFSEQIQKQLACSCSIVISPSTQKEEVLVQGNVVNQIHTILITNYFLPRKYIVLNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLF2</accession>
    <name>V7PLF2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">YYC_03409</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLF2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="12">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETB59148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="458" mass="52265" checksum="9A85E90BA086E2A7" modified="2014-02-19" version="1">MLDGIFAGVISDKKYNTFFAFRDPIGICPLYIGYAADGSIWFASEFKALRIHCVRYVTFPPGHYYICNNGKGEFVRYYNPNWWKLDSPIPNSKIDLEKIRITLENAVIKRLMGDVPFGILLSGGLDSSIIASIIARHLKSIQNDTNNNINGTCVGKNNKNLNTLKSFSIGLKGSPDLKAAKEVADFLNTDHTEFNFTVDQGIDSLHDVIYHIETYDITTIRASTPMYILSRLIKSSCIKMVLSGEGSDEIFGGYLYFHKAPNAEEFHRELQRKIHDLHIYDVLRANKSTMAFGIEARVPFLDLEFLDVVMNIDPQEKMCSNNKIEKDILRRAFAGYLPDHILYRQKEQFSDGVGYNWIDGLKEYAEKKVSDSQFSRAPFLFPYNTPKTKEAYLYRCIFYQCFPEQCAQEFVPEGPSIACSTSKAIEWDEQFKINPDQSGRYVLDVHKHSKNVEDIKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLF4</accession>
    <name>V7PLF4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLF4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="332" mass="39686" checksum="AAF9AB04CA47D04D" modified="2014-02-19" version="1">MEQTDDCSHSPINNNQEDNADMGNLDNENAEELKKKIIDLELQLEYEINRHEDEIKERDEALKQMEEKLIEMENIKSEMEEKDKAILNLSEKLLIMSNKYDILVKEGKLKDEEIKHIKNKKKYKKQATDEYIATMKKQNDEFKNDNDAIHEKYDQLLKQYDTLTKNYKLLEDELNKNINELDLEKTKKMNEYDEIVAVKMLNMDKELRQKRHTGNDEENSLKLELKYKDMIIKKLIVKKEKEKILEKKEFGNKEDTNNDIDEQIINYEKKVNELHQKCIDSQSDQAQLKNKITKYSNIIDDLKKENNELLEVISTLREYINTTYKEDTDIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNF0</accession>
    <name>V7PNF0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2358"/>
            <end position="2378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1470"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1782"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2864"/>
            <end position="2937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1897"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3065"/>
            <end position="3092"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3119"/>
            <end position="3155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="853"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="913"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1782"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1797"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1832"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2884"/>
            <end position="2915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2924"/>
            <end position="2937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB61101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="3383" mass="400759" checksum="6618B2AAE9E9ADA8" modified="2014-02-19" version="1">MFFSKERRENEEDGKRSSGNKNMSHHKNKKYVRNLKQSLYNNKYINKFQKRNKDLKTKRGGNVNYVYNNVSTDVNNNNKHSQLYFSKNLINRNNKETQNRTNVYKKNYFNHDNINYNSLINSQTPICFIHIDKTDEEIKKQLQYNDQLNSLQNNNTNNDIINDIQNNIYPTFIEEIIFTTNIVLFTGILILSNNDKIFHNLDFEGKTNPLPIECNLNIYINVVNKYNSQHFKQLFPVSYNFKSRLFYAIPDNNNSTVDSTLLIDKIIIKGNFKTLSFIVLGQSEEINEHLRYHRENIYDINMKTKINETTVDVENIEAEKDDVYSPKKPVYIKTYNIANIMEENYDFEKKNTINDHKNYENNQIDELNELSAFSNILEKEFVKNNLHNLRNINKNYHKNNNCNNVDDDAKLNEDKKGEEFGQSENMSDKHDMNKSGKHDMNKSLESDLSDSSIETDDDNNNNNFIPPNNELIIKILNCLTNLYKKKKEINKNDLPIYKKIIKFGVMWLFYIYKNIKTDEDNFLFNYSKYAEIKIYDILGCLLVLRRCALYPNLAKYIIHMQINSNLIQIDRTCPYILIYLIDILSIDGVYFLSSWKIKTSILKTIIALISNYYVMDLFCNYVDENNETLYTKLLSLSSNKKMKRYNIKRLLGIIMCRVKLYDEIHKFENSVMDIIIHREDYKNCLFNENIISKLIHEIKNIHKELYQHSCNPESKNSCYDIFYENEIFISEENEQNYNYYYTYKLHNYVLSYLEKSQFFNMFLYILKEFEKHIKNILFLNSYDISFITTLNDFIFYFLNCSGGINLLINYNIELYKKTYINICLIINKKMKQLNSNINNKNEEGEGADENDENGQNCQTGQNGQNGQNGQNGQNSQNCQNDNNENNYSQNDDTEKEREENEFNNNYDFDDPYNENNHNGMNENNQNGMNENINQIKNSGDSECIFPENNNLGFIQNKKDEDLNKEGFNNLDEKKEKKILYNEKNFFYDNLKCVYTYNDILRNKDISDIYYLNGYNYKDMKNTRNSCSYILCSIIAFYKSNLLINNFFKSEENISLEYLKIFSSLSAYPLFKLAMCNNRNILNLLTHLTHLLYYSIFLEKQYEENNSSNSQIIKFRKNKINDNNITEGDNNNSTNFFEDNNMNKSENNLISKNVKNKFYKKNSNEYILVTIKYILSIIYNLIFYDYSGYFIFHSGYSIFVCLEEIKNLIGEIKKKKDYYFGALNSKNINKFFLKDYISNDKILFKKYFIMYENLKGLYTDLYKYEKKKFSEMDIQKRKDTYRNAMLEFVQKCDKSNGEHAENGAYLNYSFIDKILSIYQENQFFNFLPLRSCYTPNVCKIIEALRIEKDKYILKKSKELNNYNCKLNNDIYISNSSKSCTKLGTTINDQYVELLEEFDDNIVSTICSNTTISELNTIYNTSSVIPNIETNSNSSLKIGYYPILPLNLLYYYMNKCPNISYFSDLYKTNHKNEHDENEHDGSEHDGSEHNEGIDKEDNKCDEENGSKFYQNKYGLFVYDNLIYNNYICIKNKKLDEKNKPIMIQTNNQFFNENDKNNDNYINKYDENNYKNIGSKIYLTNNLEFIIKLINKSIFFLNINNLKLALIHFNKLNGRNLFKIIKKRLKTLNFVKSILNVLFNFFYNLTAISKYQKIAMLKSYRNHELFYSLLYLLNKLLSFNDWLGSNNISEYNHHTSIYTLRYNIIYILRIFYLWYHNTLDNQSFLLRSVLRYTRILPCFNISGMLLLLIFFDFKNIFPEYIYSFYLSTNLKNICYENCASTTQHDDSQIDKQESDKTEISDSSFESETDSQYFQTFSNDNSESDGNLSTVMSQESGRKGGKNEDAHDDESNSSIDEVNKIKLDLVNNCGNLEHVKNINKENTQEFFNFSKMVNNNYTGIYSDVEADNEKSDSENENYNDEIKKKKFEEIILYSKIEDPYMISNISGNNIIENDRNINSNENRNNLDNINTEKKKKLIYMCCSINTTKRIINDQFLKKYRILNLNFGENEYENTFYFTNYHNRLTNNYLSFIGNLNINLTDLTDVDNKHNINIVNKEIEHSIVPPPPNTININKNIYNSLDNMMHKNYIGNNKSGISFLSHNKIDIKKKEKNKFENDNDIISNVKEKTTIQTTPYPIQNLLKDNEIDNVENIMNMLRNDEHIFEEHINIKYLKKDEKEKIFLIKKELKNREYINFEDICDYINFILRIGKSNNVISRCLSAYCCVIFINHRIPIFSILFKHIEDVISNLISITLCDKKDENNHNNTTILMNKISYFSFYSYNNTQSNNIYYTYNQELYILKELCNLLCFVLDILKICFFNNYKNSYNKLIKLLYLPSNKLLNIIQNLIIKLNNIFPQELIRFIVKIISTIFQGYIYVFFLYFTKNTIIHGHRNFPNTSMQCSRPMQCSRPMQCSRFVQCSRFVQDDTNSLFINKDILISEKQNLFLLTKKDKQCDETDDNQSTKLDTNFSEKKNEKNSNIKMEEYTQVFFSCPNYLKYIRFFFKFYFNIVNTKNVINDNNKDIIYKYSDYVNLKTVTMCLSTIYEIIKNKIIYFFIFFNVEKRLENIFFKYIKTSQNKNKNKNNIVSLFTNADNGFEKDPELYDKENYYIHYFNFFLKLNKHINISNLVEFLSFYFDIVQDNTNKNLYKIIELYEYLNIIEIILNIVIQIINYHFNSIFILIHLFQNNDQEAIKLLDHINKMYKICKIQNDTKQIYNKIDINKCRKKYFKSLSNFAKYIFYFKKHFLNSLLNSLRNLYQFVLTKSNPTNHNATTNSEPISNIEPDLLNSSNFTENIIDKDKNNSLIILANSILMIINKLQNVKRKVLNLDTSYIPSITLKNFFLFICYDLDQLHTLYKHQSLKRKTEFELDQNQNHQSVPLPKRRKLGLGEKNGEKNDENGEKNEKNEKNGEHGEHDEHDEHDEHDEHDEHDGHDEHGETRGAKRSYSFYFENMYNKTSFVINKDYLFNKLGEVFYSNYLINKIRKAYESHQHLDNNYLNTIKNINISNINPAVNKKIYDYPSHLFSDILSKIYLYENDEDKKSFILFNLPQENKSKEIDQTHSLYNYINVLKEELNKIEKKKNELLSQAKNKQYNKKNDKNIYDDHFRNRKTISSRAPSKHVDDYEAEKGNANQTINNENENDENKQITEQTELLSNNEISSEYIGTQNKNTGDLNLGKNDNTFTNYTNKTNANNANANNANNVNNVNSVNSVNNVNVNIFKNTNISSGIDMEGNVINNFNDDDNNLGKNQKKIQKKNINYLTKNNINNDDENIVINEIDQNYQHSNCNNNIDTTNTESNNKNISPDTNELINKSSQFEDCTCYKFTLLGWKEFSEDGHKHDLDVCKIVNKPVLLKDPRIKMKFLRILDRHNNIKDIFKKLGVDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNF2</accession>
    <name>V7PNF2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNF2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF9">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="824"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="866"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="997"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1034"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1138"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="700"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1177" mass="136765" checksum="34A588B48951D535" modified="2014-02-19" version="1">MEDVLENKKYVYKYNKENSYIDMQRNETFRSNKSGNMDETEKDINETNSIYIENLQDENNNINFYDNNNINFYDNNNNNFYDNNNNNFYDNNIEAIKQANGEIQEKYQANNKYNNGNNKTPFAHHTNVSINNKGDHFYEIDNKIALQKQTAQHTNHNVGNHNVGNASDGNCNVLLLNDKSNFERNEKFLNFEKSQKLPNFEKNEKLPNFEIKENEVIYNSNKTNESNNLYSPYYNTEEKEKKQNSIGIYQLNYVNNINNVQFLNSANSTNCTSNNNNANGKNELIYKNSLKKLNENKAHIYNNIMDTQHNNNFYEQNKFNISSMQNNNRKRAWIAQNENGQNYLNHNKETYENNVNNRYNEFGGHIHLYDNTEENSGKNNEENLCNYYKKNDRNEQNEQNERKCGRYYEESKTPLVSHAYIYGENSEQLIKDYNLKIMNKKIRNVSPLHHRAYSNISHKKETKNKIISNIKREHLFSDQTGSNIKYQYNNSPYQKKIKGNKNISLSEIEQKKNINEINKFLNIVNYYENDKNKIKDTEDVSVNLDLVKTFSPNFDKNSTKLSENNYTDKLNKWNDNNKISYNELGKLENYTKCKMMNSYENSELENFEKRTSFSYSGILTSMISSILTQQNDRKIEKNNCLYNNFRGNNNISKNKENYEYNLLYNIKDGEEIKNKYIFSKKVSNKINLKNKKNNNILLLTLTLMIGLSVLCNFDHGAIPVTLEEIQKDFPLSYIEQSLLGSLVYCGLIFGTIIASILFELISAKWLVTISIILLSISLYIFSNANGIIVMYISRFVNGLCQAIPVVYLPVWVDIFSPEEKATQWMSYIQLASIGGTVFGYFLGGILSNNYNQNNILFNNMSFVTTWRSPFLMQAFLLLPIFLIMIFIPSSMINISSKYSDIETEEIENNNKINEKEFGNSNFDNLGMDEYNEMTLNSQSNILTNLNKKKKYILPYQNQQNNINRKNYNRSATYIMEQKTNILRKTFKEVKKLLNNKLYIIITLGMSNLYFVVTGIQFWITEYMSVVLLTEKMKIVTVSTLCFLTSPTSGVWFGGFICDLFGGYKNTNYSKTIKVATAFAISACIFGILSAHLTNFIFFSISLWLCLFTGSALVPVAVGMLLSCVSNHQKSLSSAVSQVIYNVFGWFSAPLLSGIIMDIMHKYTNNNRLALKYIIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNF5</accession>
    <name>V7PNF5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNF5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1157" mass="125587" checksum="CD73BE915BEEBCBE" modified="2014-02-19" version="1">MPKDMCMIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSVPTGGQSGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNG0</accession>
    <name>V7PNG0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNG0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1151" mass="124853" checksum="BBDB0D9D443B3B36" modified="2014-02-19" version="1">MIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSVPTGGQSGPTDGQGGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNG1</accession>
    <name>V7PNG1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2050"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1670"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1732"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1670"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1683"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1732"/>
            <end position="1749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2072" mass="245562" checksum="1C60228AFE9DD329" modified="2014-02-19" version="1">MEPKVKKLNSQKNHEIFLERNDKTCIKNMLNNKKCDNIGHNEPVSHGLKNKENKIQYDKIKKGDSSLDISSIKKEKEYIKKGNKWKLDIFNSLENVSNIKNFVKRPFLKSYKILFRGSKYRKKYNHILRNIKKGKYHHNNNLGKNVTCWSKLEKKILKITKMEMDKYKVKLNDKRKEKKFKNKSQTYKHERVKKRIYSSSPKKEIIKKGKSEEIRSKKHINSVKHKRNSEKTSKNISSESNNNSSIIIMKKSKSLKLEKTDKRSSNYKDENINYDGIKTIGSEEFHINRSKNYIINHSKDKKKQEKRKIKRAISTFFKYSSEYINSRKRGVSLQSLDDSNELNKKGSRYSEAGDKEIYETYIDKLDKKLSKTAYSLTNIENDNNLKDNSLNDNNLNDNLEQKPYSEGNIKEIYYKYTKKNNSTDFQFENMGRKSIKNNYGDKGKSFDIRYYNDQTEKDNKLITDEIYNYYYKDRGNEKKNKISYNTHNERSNYENKYALMNLDEQKNEHINEEYGNFNNDNTLYQGYYKYYENLDDNDLNYYSEWDDYNYTNPSKEYSAEMKKLNKLYYIYNEESYSKENNAQIDNIPENNTNDYKDSTYLDYMNNLENLKKDENNTFLSELLMQSNATYNEKLAMILNLSKDKHLYRRIKKLLEKKNYDNDIKNILIYFLKCIKSGIYLPKDDDKKRLTNVKKKNFGKTESRKRRHIELKENDTETKSVSLSDSIQGNKNICLKKMYIENAPNSLPLTMLIIQNFEKKKKKNDKDIKVKYKVELTGMKNKKKFSKLVEDEKCLFSRIDKIYSFCRLDEKYKCDEIYNTNIVNRFIPFPNLKNDLIKKYNISKLVKFKENTMEKEKINDVKHSFLHINKVFNNNKNVKNHIYKPNFYSKIDNKFKEISKLEYTNNHTLESTISHVPKCNTNSKLFDEKTNNNQFVKEKILALQKKEKSFFLNKNKIHPLKFYKSKGLALFNKKVEGSIKSIVMSNSFLSKDKMISDIENKSTQLNNSLEKQISLYVSKNNVSTNSNAKNGGISNEHLETERKNAIIKLSSIKSDIIRKKTHQKNIYDIMKEKFSAKSCINLWKIEGGKIMYRENKIDQKSKLFSGGESRIKNKNHEEIRIKNMSGNIKPFYKEKYKSRNISDINVIGMKNGKSYIKINSFINKNSMVNYYNEYNSNEEKEGNKNMGKFTKVLDGNNYDKKELFNTKIESNQNRTFDNENDKILFVTEESDSINEDRYYNKLKYSNTNKNINKLEEKERKFLHHDEDNNILKDKIDFIRNEKIEKTKNISSNYINSELVHNNKNKNDMNRKLSVKNDLLFYKNSYNSMGREIRIGNRNNSSTNVDSYKMKENQRIYSDKEMYPFFSSSLINQIYENSKDNIKENKIFKNNSGNFLQLNKFPDKVNKSFKEIPKWGNKMVYKYKTNKGNSYYFLNGNKKNIYKTYINSDLSLPLSNLDGRKSEQNKNVNIFHKKDGNFLVQRRKYQREGANNIVTFAKEKKGKSDVSNILSTNKLLNIHKKNSENIDSSDYEKIEKRVRSIINTPSKRYIHREFLSDSFETNSFRKKNKSSETIQFIKPKRDRTIRNRNNSDHMGISYDDKFIEKNNINRYSEKSKFKNSNLIKKKSNYVDIRSIECSKSTLEYFVEKDYLKKMTTSIISDSYEIKDKTKKYKKNKTIPKKKNEKKIEKKKEKKKENKKEKKKEKKDILIYPQIYKSYVKEKINKNEEIKEKKNEDKFENRDKNIHTEMSKKLLISGTNEDIKKKGKHNKNKENKNQKRHQSYKTDTKSSSDNYNLNEIKRRTNAKGIYGKKRKTFQSSINLRSNSFIEKLKRHINVKRKLNLTSNNIIKYFSSDLDNLRDIEESVTENSSQSITSDESDIEKEIINSDAKMGESEEIKSFSEVSDNLLTIKLNIITIFLEGFHIRKNSLKKKYNIKVTIYSSNDIKTLDNDYITQEVFPCYLTSHPNGIGLSSDVFKKIDVSCREGLCGFFKVVVSCYRDKSFLKMELFRIYSQIFKSPVELKRYNLSRNKKYALETSSYNDDSYEINGFVSLYISITVMHFLGLFVLSIPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNG5</accession>
    <name>V7PNG5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNG5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="849"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1144" mass="124240" checksum="ECDD10D799DBB08B" modified="2014-02-19" version="1">MIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSVPTGGQSGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNH0</accession>
    <name>V7PNH0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNH0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="27439" checksum="C306F40CA7CF1AC4" modified="2014-02-19" version="1">MNTEETKTVDKIMDDAEMLLQYHATSTNGYKLYHKHGDDSIEYFKKDGNTVIYKLNHKINRPDKYNDIIEMLWNPNVKYSDDNMLKEKIVCHYSPNIMMVQQRFIYDSLSFHGYYYAFAKKVQVSDDITIIVYTSSNTDDYNSVDKTEYVNPIVDSAHLVKPKIYSEKDIRDGELTKMFVNLSGYIIQKKKDCVDITYLDSIDINAPMFENILIRIVHSAHILNILNISTIISMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNI1</accession>
    <name>V7PNI1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNI1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="162" mass="18963" checksum="D31529CCFCC3BFCD" modified="2014-02-19" version="1">MNEKIIKDKLRVSINHLNNRKLTFNLKTFPINKTICEIFNICTKVFKEKLKTAINELKTRKTNCDICSETIDQANLSLLYNVDIATTTFLFQKIEVCCSKCYMIRNFSLFSSELYENADSSAFLNFSTIYEHYYNVNNLNREHKNILINDIDIFFSLSVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNI8</accession>
    <name>V7PNI8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNI8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="106" mass="12366" checksum="8B779F7B227EB245" modified="2014-02-19" version="1">MLQNKNVYKDFIKPPNKFLHPDDENAVIPQHKIAKSIDFRSEALPLSGFAMIGNRRKYDLEEKMEIKNQYGNNLGLYDNAEISKLIEDMHKRSKEVMKTLQTNKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNK1</accession>
    <name>V7PNK1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNK1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="205" mass="24298" checksum="F36B62C1BEBA07D0" modified="2014-02-19" version="1">MENMASCSLSIEKRYDHLKAFSNNIGGLVLELKDLIKVHEILIYKEKLKNSEKDKIKKQQDDLLVLKQELEIIKKENIKMDEQLKYYKRIDGSINSQISNVSENIQKVKLNINMEHKKKMEMTKNINEIKNKYSKTLKQKQLMNDKFTHLSKNTIGKTELSKEVNKEKCKEVSRDNRYKTTSQIFNTNKTEDNNTKKNNEIYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPI6</accession>
    <name>V7PPI6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <ecNumber evidence="7">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="7"/>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPI6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.20">
        <property type="entry name" value="4-hydroxy-3-methylbut-2-enyl diphosphate reductase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426:SF0">
        <property type="entry name" value="4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="464" mass="52575" checksum="3E76530D5C34AF3D" modified="2014-02-19" version="1">MHKIGKKIEYDSFHNPMYGMLNVRSNFSIPTIIKWKNIKKYGFIHKTENYNYQKNNKFNIFKRPNNYTINYKLKVNLFKIKNNKDIYFLSVNGNKNQKLNDTNCGGGCNMCSSQVSKQNGAKANGDTNYGDTNDSDTSGDSTSGDKILYLVNPRGFCKGVSRAIETVEECLKTFKTNIYVKHKIVHNDIVCKDLENKGAIFIEDLNEVPDGSILIYSAHGISPQIKELAKKKKLIEIDATCPLVNKVHVYVKMKAKEGYKIILIGYKNHVEVIGTYNEAPDCTYIVENVEQVNNLNFTENQKLFCVTQTTLSVDDCALILNKLKEKYPNIETIPSGSICYATTNRQRALNKICTECDITIVVGSQSSSNAKKLVYSSQIRNTDAILINTINDLDFSILKNVKKIALTSAASTPDELTQQFVKVLTNPPYNYKLNIFNGVEEIVPKWKLPKELINMIKQKKEDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPJ0</accession>
    <name>V7PPJ0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPJ0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="43188" checksum="A9E5803FE200BE86" modified="2014-02-19" version="1">MEIKNKSKSFIAVVLTDPSLRRLIFFILTSLIICFLPIYKAIRYIVAKEYGGLSPFDSILYHCITNIIVIIIFYFVLLKKNIGGTTKEVIVNRLKLKGKCIIVTGGYRGIGLAAVHEFLKYECHVVLACRSISHMDFIRASLLKKYPDAKIYCVELDLGSYKSIENCANYILKTFPKIDIIVNNAGFLNRKLEYINGLESTFFINYYGHFYLINLLYNRILTSGTLIVNLSSIAHSLLKESDVDYAFIYENNNDNYSKSNLLYRKEYNFSKLCMLYYSQQLQKRFEMQKSDACSVSINPGLVKSEFFRYEQSWFKAICKNFAFPKTTLQGAQTILYVCLLDRRELAKGSYYSDCKLDYIRHYAKDMKKSEVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPK5</accession>
    <name>V7PPK5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPK5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB61359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="236" mass="28118" checksum="F2E8DC536103797C" modified="2014-02-19" version="1">MLGNVIKTRKLYTVILKNQFYNFLSRKQHWYSQYNNLKNRDSLSYLYDLYKSIESCKSGHMLYKLSNKTLNYQIFDLHIWRLIENKFYELNKELTPKELSSIINHFKQMKINDSKIYENSIDIILASLDNYSIHDLSLICLSYTYFYKVNKNFLNKISSAIINLYEHEKNNIQNLTKNQLNELFISYVHIIGSYSKIQHKNIDLFKAASVYIYEALNLDINVSPKIILKIINSYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPL1</accession>
    <name>V7PPL1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_01430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPL1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="508"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB61561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="825" mass="98694" checksum="41DA403339CF4F18" modified="2014-02-19" version="1">MDISSVNFESGWKIIKEEAIDKIEKYLDENAVEINNNLFNAAEYTRLYTVVYNMCAKKTPFCYSKEVYRKYGESLSMYAVNKIKPQLKEEDNLKKTKALIDAWYKYSFYTNWMNKFLHYLDRYYVEYNSSLCLKAYTKNIFKLTLFDETRECIKSIIYNIYDSMRNSDNKDNEKLFRDIVFLYNELDKESAEKMYESDIEKKILENVEIYYNKEGNNWIQKMSFHDYIILIENSIEKEYEKNKSLEINDETCEKVTNIIVRILIYEKLNLLLDNKENIYNLLKNNDLNSLRRTYILFSYFSEAIDGLKKIIGEYIKTEGNKLKEKYISLSISINNNMDTPTYESNKNSNIAEQKNEYILCEYIHDLIKLHDYYHSMFNFSFVNISNNEIDTNFKECLKDYFESFVEHEDEYFSTVKLLVLYADNILTIKNDKTDLQMPYVKNNEEGEHIKHEMKTVINTDELKNDYRKVGNKEGYIGNLNDVRKTRKENDDADSTCDTNIIETDYLIKKMSDIVAIFNYISNKESFFEYYRIYLANRLINNMYISINVEKKFIESLYFLCGSQYTSKLGGMIQNIINNKILNEKFYNYISRNNSNGGISLPNLTNFDENYENNFFSVKILNKGYWPALEKTSMKLSENFNKYILSYTEYYKTENKNKKLEWIYELSEVVFKYFINNRSYYLYCNLISAEIFLLFNKYKYINYDIIKEELQIDLKTFKDNMHSSLYYHKIIYSDDDNINWDTSNFYVNENFSYTNQNVYIKKTTTLLSKEHEKTKDDKTMAIEAAIVRIMKTHKRLFYDQIFDNVKKVLSTFAPSNQVIIRSYASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPM7</accession>
    <name>V7PPM7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_02307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPM7"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB60687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="38746" checksum="D547603F4D719B3D" modified="2014-02-19" version="1">MLIQKYDEKPKFDIGISPLYLISYPIYNIQCRSILYKYLNVSNDHIKYSQPIHVNNLNIKTYIIYIINSLQQIYNNEGVTGLYSGLVPMLAHLISKKSIYYFLENIHFYIFRKIRNNKKKDTIDKKNIAIRESRFLNEKENSNNFIGDKINFNIVKHMIFVKDENYFVKKKKKKDNFYLSFYHTFYEYLSCIISYPLLNISTKLIIFEDHTKSLLQNLKNIIHFTYVYDGMYGFFRGINNYLIIQSVDKFLNCFLYKTFSNNCSYDKVLTIKVVLSTCLNTIMAPYIHYSILDRSQSYIPTLCRNTTFSQFFCNFHWKVNIVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPM8</accession>
    <name>V7PPM8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_01289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPM8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="8">
        <location>
            <begin position="9"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB61384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="178" mass="21246" checksum="B24CC538AE98397C" modified="2014-02-19" version="1">MFIQNLKTLFYIYIIQLKFFRSYEIMEKYRSCSITIMSINDKKKDIVFKSENKQDSFNIKVDKSGAYSFCYDNKKNVELTMMFTIRVKENHDGDDIEIGTKDDVDKISGQAFDLYSQFLEVLDQQERMMEKADLYKQINDKINSQLVIWSEIEIILLIILTIIHIYYIKSFFEIKTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPN2</accession>
    <name>V7PPN2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_01293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPN2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="266"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB61389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="310" mass="35454" checksum="3D8B38761EA76D7F" modified="2014-02-19" version="1">MSSSMKERDFKPNRITVILECVEIFLKNFFFKNPVGHVGVVALKNSSAKLIQQLTSNIDDVLNSLVKEQKEGLNGSPSLQEGLEIAHNLLMDMPLYGTKEILIMYGSIRTCDKKNILKYLDLLIKNNMYVNCISIAPEMHILKHICEKTNGIYKICTSKNILINEINQVAETPLWMHGMEPQLIHICFPVKKKINTQIVCSCHNILNTDTYICNFCNSYTCKIPSKCKICGIHLISMHDLSHITNNLQASPLFVEIKNEQNYYTHCSSCNQQLYDKVSQCTKCKNIFCLECDVFIHEDLNQCPFCLNDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPN6</accession>
    <name>V7PPN6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_01435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPN6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="14"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB61576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="291" mass="32938" checksum="4AC439D7B11F8F93" modified="2014-02-19" version="1">MPVVNGAHVISMKNYTIVSDGYGEKGIKKTFEDEFFICENLNVYNKSLHPNFNFSCFCLIDGHNGKNTANFLKKNLAQELSNSFTKIQETYDDTLPIPDHFIRIGVNSACKKIDENLSLEYPGCKDGATCVIILIKDDFAYITNIGDSFAYLCRYLNNAHRAIDLVDIHKPWVLSEKERIIKHGGTIENGRINDIIDVTRAFGDFPLKKYGLLCTGTFKKFKITSDDNFILLGTDGFFSFVDINHVTNEIVALSKKEERLVNVEKKKAVFDAKIICKNMVEHAIIDKKSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQ03</accession>
    <name>V7PQ03_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQ03"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="1">
        <location>
            <begin position="87"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="498" mass="58686" checksum="4B4C375B3D06A040" modified="2014-02-19" version="1">MTETRKIVNLSASDIICFLHPRYGDYIMLNLYNDINKALESLKNDEHGRFKNSKICLLGYSLGSAMAYEILHNVKVRISDNNLKYELKSKIDYLFMLGSPLSALLSLYKPEYINDGLKLIDNIKFYNIFHGFDPVAFRIEPLIYPKVNNISDPVLINYWRNNGARYWFEWDKNMQNAKIAIVQNLNDITSAITNGFYKFLWKSEPNTEEQGTLNKNLCYNKCESKDINMFLLKVKENQRKIEGNKHKNSQDSLSKNQNDKKNIYHEIKNSNQYENNDSCSNNTSSYVDSTKSIYASQDSNSENSFFDNDFSDISDGIQNINIEKQNIIKKEHIDNDYNQSENETSQYANNVLGFQQNRENRESCENNNLDETQTNVNKNNTLPIRYDYQLQEFIMEHYIYPLAVAKSHFNYFIIKDISFFILKELINKETPISYEEYLTEIEKEYNNKYVHEKDNIKKEQYQQISLKASKLLEEFHKFEKNMEITSDPFNIKNFKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRM5</accession>
    <name>V7PRM5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_01304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRM5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="10">
        <location>
            <begin position="95"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB61402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1113" mass="129729" checksum="07B99AAF5AE10910" modified="2014-02-19" version="1">MDELEVAILCLYGNENSQINKNEARKYCEMFQNNSDSWKYCITKLIESDKLEIKFFCVNVIIEKLGTLKIEDLIYIKNSLYTYLEKKYITINEDPCVVNKLIQLYLYLIEYLYPNNNMSDGFKFIINNIMVNNDINIKNIYILFFLKLMNMLDTEYIDNSYAKKNFQIVTNLKESIKNNDLPLIVECFYYIMNLNIEETTSLAIFTLAKYVTWIDINYVVNDKVLSFIYNSLNSINSISQASYPFLTSLIKKGMNPVNKIQFIESINIVYIIQNSPKIVDISFEINKNIMLKKGELINNICLELVESIFEITKLKDYDINVMKYNEICDKATNLLFIILPHALDIFSVNDFYITNTVEQFFSLFFTKFKGIIEFSPALNNEKNNNNNSNNSNTGNVGNSYKIPMTKLNVFINSLMCTTVNKFEFPSYIGENYDEEDEDYITFLNFRENMEKLFQRLILFDKLKAIEITKNAIQYLNDNFDNLQWNSIECKLYAFYITTSIYSEFKGNSNTNNASNNNTKQQQQKDCAEISLSYNNLLYECLIELLKNRKIVNCSNHLININLMEIFQRLNLFFIKNPQYIEYSLHVFITNGIRSNKNTVVKKAIHIFKKFIKNNSIVISNYIKDILQMLEPYIDIPCPYQKLQNNGVIVNSPFNTLILNQDTIKSIYTYMYSEKNYTYDDQIDIYETVGLLLLYHDFSRGKKIINDEVYQQNNRTPNNMGNTNTDLNSINEKMNEQIIPIYKERILFFKGVLNKLLENLASIKNLYINSPKTQQDTICLSFTCSIIIKCIGALCKNVNISMTDTLINDLDNTLGLILSESLELFYTNYLVRDSVLYTYRILSNLFKELSLNYTIKILPYFYNISYNMIMEKLKKGNNSDNSGTTGNGFNMTTPTSYQISNNSSENDSKNVSNRYQEELKYLYNELNELSILVCHLISTYKEKSFDTFIKPYIHNITQIHLSVWKCIHVQSIEMQREQNSILSPLLLIFYNISLNIPTAIHNFISFEHIAINHKHFCDLFANDDLIKTKIADAVTSILLISLNYKNTIDLSICLYSFQTITNILNSAANMPTADEILSKYPLMQIIETICLSLKFLDYSDPKNKRVKINSNNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRN4</accession>
    <name>V7PRN4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_01313</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRN4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="11">
        <location>
            <begin position="147"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB61412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="292" mass="34882" checksum="D10BACA744F7C01E" modified="2014-02-19" version="1">MDDNFIQNSRKKNQNVENMNKINSIISHMELMNNNLKNIFSHEQIFSDHDSYLLFRGKISKRIVDYSQLISNCNDKILDCEYLEDDNEKRIKDTLEEHLKNLENYKRGLSIWWRKNEKDFHCLCMNNFLNLQKSDSDIISTDKKTDNKSLKDTKKIMIDEINRMKNVRSELLESSQKLKKQNEIFNIFEERLRSSANLIFSLKKRADNDARYVWYSFFLFLSVCGYIVMRRLGFIRAIITILKLLFSALFYLIKMCIGLFYFMKEKNGIENDFTRKEDLSKSLVMVIENTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRP0</accession>
    <name>V7PRP0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_00865</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRP0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000085">
        <property type="entry name" value="Tyrosine--tRNA ligase 1 cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB62256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="344" mass="40145" checksum="D35E7F15E8A5B95B" modified="2014-02-19" version="1">MLKILNTRIFFNLASHKSKYFFYKQMETINIKKEDNEAQVKISQEIHDENVEKRYNEIMSITSECIQPDELKLKLLQKRKLICYDGFEPSGRMHIAQGLLKSHIVNTLTNNGCTFIFWIADWFAQLNNKMSGDLNKIKKVGQYFIEVWKSCGMNMENVQFMWASDEINKNPDKYWSTVIDISRSFNINRIKRCLTIMGRTEGEDNYCSQILYPCMQCADIFFLNVDICQLGTDQRKVNMLAREYCDIKKIKKKPVILSHGMLPGLLEGQEKMSKSDENSAIFMDDNEADVNRKIKKAYCPPNVIESNPIFAYAKTIIYPHYKEFSLARKEKNGGKYVNKMCNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRP8</accession>
    <name>V7PRP8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1450" mass="165550" checksum="412851AA5E3B6914" modified="2014-02-19" version="1">MNPNNKNFASSQVNMPRNGMSDNNHQNNKNILNSQYGNNMNAFKRNLLENGDDPSKIPLSHYNNNVNFNNNNNMMKGTSNSSPINYSIRNPNFQNTENGIYKTNNNMYSSEYANGSSNNNNFNSSMMPNLKMKNIITKGNGNPVNTNMSNNNLINNMNYTNFPNKLKGNIDDINNKNNYNMINTNNKVAIPNIYRNMDANNNNIDASTIISSNTSSLNTQNGNKSGNLNSVKSIDLVNRNNLVNNMRNMNNSGNVIRNNNFQNVNGNNMNNIYMNMENAKSGIDNFKNNSMNPNVNTMKKQMNTIGVNGSNNTPNINNNMNININGYKEMASFQTLNRTHSHKIDNSSNINNINRRSNTVGASNNSVNRNVNGLIRGTEHGNNNDGNNITNQYYNANKLQGSMIDHNARNIPKNLNLNLNKLPNMHNNNNGNPKYIDNKSPMYNINNNIYINENNGNSENNRNFSNIQRNNKNIYPQGFSEKINSMPNNELNNIQNFVSTKTDSSLVGNNGINPTKIMNCMLPNIDNTANGMNIVKNGDNNNLIIPKKRKKGKDKDVITLSNPTNNLLENNGDNNITINKNTYFNNQNVNNALLGQNAEELKNQKMSKKKQKNNDDNPSKNDGKRKKKMMENNLNNMPIPAYQNNSISSMPNPMTQQTESILMRNVNTVNSATNHTNWAGFPSTQKNITPGTDFINNGEVNGSNNKSLSSYKGANIDENINNNNTNKEMMSNGDQMKVDPKYIWLFLNNEFNDNKTKYAQILPLLKHYYPNRLNDLILLLEKYSLMNLNYIINSSYQLQMKLIKNYNRLESEKSGNTNGNNPMHNENIPIYEGMNSSIYNSNAENNRINNELNMRNIESRNVENTNIDNKLLNSINNNFNNLMYNMNLDGSLGRSNTNEDIVNNKNTTKGKKSNSKENTFKDEGTKKPRKPRVSKKSQQNNNLAPLNIINGTENNISIENLQKNNELKINDNVSSVGFGVHNVNNESCDKNNDPSKITENGVAKFLEVSKNELVEQLGGNNIDNDVNKNTKVRKYRKKKKNDGDNDEGNTLNISLDAVSIDQIQSSPNINENKRKKKKKNENIDNTNEENSTEIQNLLSNDKGNESIYANKIDRLGMNSKEEDIINTQILDSIVSDYKKSENEINQGIINNNECAERDDKNKIDEESGDKENKIEEEINETKKKKKSNKDATKKEKGLRKNKTKKMEMANMLQSYDSINGINYALSEQYNNLYGKKITNIKKLCYPQNNLLAYLKEAGLYNNLLGKTNRINSMNAIRKKYKKFSFCVNKVFKKQNINDIITLNDNINNNKQFLSLFKKKDIRNLKRKNLSFFMDKLDFQKIDLLIIKRIHICMEKIKNTLGLTCVINNVEQIIKILKDAFNDRMKFIWPMIEFSNNYRLDQYFHVLGKNRNHPNSNFRDTRIVVNQNINSLIMYFNQRDIDGRMVRMKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRR1</accession>
    <name>V7PRR1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_01817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRR1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB62094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="57059" checksum="3F82A901A96947A4" modified="2014-02-19" version="1">MGKINGMNKMNKMNKIILIADLHSLTNINNIFSLKQNVLDSVKTIISLIINMYVKKKNYIDIYINDINIKHIIKHLNINIKDDINIQNLLSYNGDNMYLNLYNEQKYVNSNMINSSKIYEQKDIFTSHHSKLNRNRQNDNYKFYKKSNIKQIHYFYIIKQSDIQQHTSLYYLINSFIPINILNSHIHIKASENKKTFSLFSYPNLMLSDIMLYKPHYLIIGLDQKKNIEIIKKISKKINTSLNKHIIKLPKIYSSKFNVEIMNLDGHNKMSKDKELSTCQNLHKVIYLFDNKDIIEEKIRKAKTDNYNTLIYAKHDQKEINNLINIYLFFFYHQIKNIYYNINNSKDSTNQFCFLQNSLFLNNIKQNCISHPTNVYKQNGQNGQNEKNEQIIFKKCNINPNFNASVINDILSTYNNNYQHFKYDLSQLIYKHFIFSKYCYEKLYSEHRLINYLLKIGKQCLYQKASRTYKNFKKNLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRR9</accession>
    <name>V7PRR9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRR9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="42120" checksum="13F9F49491E5A704" modified="2014-02-19" version="1">MKTILKYAKKKNSDQNEITNEDDQTTINCISINDININDIEENVITRDNNNENKKKKDKKIEYYLFDVESYNSNNDTSLNSVIDLNSIKSHYLPENKKKNAKKKASNYIKKHVKKYKKKYKILPEHNLDQDTSYEESVKNEKKDYDTYELKEIKNDKTNIDFVPSQKKENLSKKNNSFIDVIKFVFLISCIFSLGSFSTTITKYIFFVKKFNYTQIVSFFEFLVMFLILKTFIFFAKIKSSTSLTRKQYIRYIVFISALLGLSAISGNSAYSYLEIPVISVIKSSSLVLIYFLSIKFGKYIFYKFELFGCKNMKRAKSINKCTIIMLNMYMHVHIATQTFYIFIDCLRSSIFRRFKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRS4</accession>
    <name>V7PRS4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRS4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB61063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="709" mass="84091" checksum="EDE33FE53B1A860E" modified="2014-02-19" version="1">MFYGTNSITGFFLKKIRTVKRAKNNEKKYICCSYIRNDISIEKDNICRNFQNIKTQACISLKYNRMDANVEKKIISNYNVNIEEKKNSDNSSEYIYDDNKNNECVIARDKEKQKNVSDNIEKEDTVLNSKIPKKDTINKNHEHILESEYNDMINEQNNNINNLSLGKCISTQKKYIYKFEKFSVFSFNILANSLVDYKYNNNCASVMKWMNRKKLIYKNITNKLSDIICLQEIEKLYFIELQEKLKLLNYKGIFLKKNKETCKDGICIFYNTKVFELLFVDKVIYDKSIFFKKWHAGLIVALRNLKSKKIEYYDSNKNGCNEQINDNLKKNNNNFVNDAHDIIIVSNTHLIFDSRHGDIKLYQLCYLTYRLVFMINKCIKYIKESVKQEKGDKGLIDSSEENTEEHEKDELNDILKPAIIFCGDFNLTPNSLLYYYITNRYINLKNVNLKNISGQYLMFKKQLYIYNSLNGVKIKNIFDENILNDLKYEKYNNLIENMKKESLFSFYKDENILNSEYLINSFSKKKNNLKNFDSFEYTFKKLKNKSSEETYEDVNSEKADSKINESICVSKQEDSVSKFNEIFDSVDTDEKEKNKPINYKTYKYNEKTIKENEKPNVEMHENTKMMDNDDQNFILYYPLYLESIYNGCAQNNVEEKCYKYDDIENLNNSSTHLMIRNVPFTVFHGKQKGCVDYIFYSYKNLKVSKKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRS7</accession>
    <name>V7PRS7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="15">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">YYC_01517</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="15"/>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1229"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1262"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1315"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1349"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1380"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1408"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="1199"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="716"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="899"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="932"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1012"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1013"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1014"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETB61675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1509" mass="172278" checksum="D0AE3308F05E8944" modified="2014-02-19" version="1">MPQHIKGDNVEASETQIRINGVNKRRHTNSVITSKYTIFNFIFLNAYEQFHKISNIYFFIIGVLQLVPELTATNRIPTILFPLSIVLIANAINDAYEDWNRHRTDKIENNRVCYVISDGDLSQPNISSNVFIKFIQYLKNILFKKSKKIDSIESYYDDEEEDEEEEVIDEIADTNYFINSYDDRLENIDGTIQKRWKDIEVGDIIICRRSDFFCADILLLSSSDPNGICFAETSSLDGETNLKVKEVNKYIFNNLTYNIDEAIEKAKKLRGYILSEKPNKNLSTMNGAIYLESDVNTDVTNNKEIKKSISEGSSHREEIETKKDINNNFIENKSNDDLNSYKHDDKYVKLPFDEKNFVLRGCKLKNIDWVIGMAIYIGKETKIQMNSLKPVIKYSKLEILTNKLTIIIWLIQVFMCIISAYYSAVIVSFSKKSKFKYLPFNLVDPRAPIVSGIVSFFSWIVITANFIPICLIVTMSFVKVVQAYFISCDNNMVYKVEENIPSFVESRQKSMKSRKNFSIEIDETHNKLNEGKSMVGTDKKNGTNPSDSTKIILNSEDDNSDIFKKKSTRMRTFKESREKSYISFNAIPRTSSLIEELGQIEYIFSDKTGTLTCNVMEFRKCAINGISYGTGLTEIKRKILKKNNIPIPQEPVDLDPKNKTPNVNIVDKKLVNQLKDVNHFNHASLIYFFLHLAINHCVMCDTSDNVNTYSSSSPDEEALVYAAKHFGITFLYRKDGKCGIKIFDKVYEIDILATVEFTSKRKMSTIVCRIPVPSNESPEPTPIDNDDMSRPRNVNGVTNDIRNTIEKWNNGNLTTGKGGNGMGDSPVNLSTEKELNISSAAIEQVKDNVANSDVKKEKMINKESNKIEKKNSKDKQTETNNDVISCKNTKKHKIVVFCKGAGCVIIKKLAKKTDVDDLTIEHMETYADEGLRTLCIAYKELSQEEFAVWYNSYKEASLSLNGREENIEKIAEDIEKDLILQGVTGIEDKLQEGVGATIEDLRLSGIHVWMLTGDKIETAINIGIATNLIDNGSEQFIYTEELALNEDLLMKKLDEDIIYIEKSLNLLHFNFDTNKVEESFFKKMISNKYKNTDSLALDHDTYKEDMTLNNNVLIVDGNVLDILLSKPFERKFFYLADKCSSVICGRVSPYQKGSIVSSANRLLKKNTLAIGDGANDCNMIKMANIGVGIRGQEGVQAFNSSDYGISQFRFLRNLILIHGRLSYRRISKLVVYMFYKNIVFIFPLFIYGSISLYSGQKIYYEFLLHLYNVMFTSLPIVILAILDKDVSLNTALNNPCLYKLGIHNFYFNINKFISWVLNSLFQGLLVFIIPLYFLAYYNIPSSTGEPFDIWSIGCVTYLLAVLIVNIKILLETYYLNTSPIVAVSMSIISFIIMSIAFSFIGIGNKSFLGVAILLVKSLRFWLVLLLVLFTALTRDYVYKVYKKNFYPEAYHLLQDEEENNSNTKHIQYSSKCSNNVDETKSSKSEFMGYAFSEADPVCVHFIRKQDKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRT0</accession>
    <name>V7PRT0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_00904</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRT0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000049">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="250"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB62301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="452" mass="51580" checksum="DF2F1A7309C0D4FD" modified="2014-02-19" version="1">MPREIITLQCGQCGNQIGVEFWKQLCNEHNIDQEGILKNNNFINEDRKDIFFYQADDEHFIPRALLFDLEPRVINSIQASEYRNLYNPENMFISKEGGGAGNNWGSGYSQGHKVEEEIIDMIDREVDNSDNLEGFILSHSIAGGTGSGMGSYLLELLNDNYSKKMIQTFSVFPLLTNESSDVVVQPYNSILTLKRLILSTDSVVVIDNTSLNRIFVEKLKLNNPTFQQTNNLISNVMSASTTTLRYPGSMNNDMISLISSLIINPKCHFLVTSYTPITVDKHISNVQKTTVLDVMKRLLHTKNIMVSVPVRRGMYISILNIIRGETDPTQVHKGLQRIRDRKLVNFIKWNPASIQVTLAKQSPHVISPHKVCGLMMANHTSISTLFERCVTQFDRLFKRRAFLENYKKEPMFSSADGQGNFEEMESSKEITQNLIDEYKSAERDDYFSHTYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PS07</accession>
    <name>V7PS07_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitric oxide synthase-interacting protein zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PS07"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26873" checksum="6BE302E0515AE930" modified="2014-02-19" version="1">MRKFEQCWICLRNSETPVSTPYGHIFCKICIINNFLAQKKEYSKKKKEYENYIKDMDRKKKEEALHIREKEKIKFLDDLENVHEHVKKTDEKKTGVDISNNFWIAGNAKIKKDIDKKLKPPSNKLICPISGKPIKMSELITINPEVIDKNDTINGNWVCSFSKKNIDHNKAVLIKKTGQIILKSIFEKFIYGKKNSLEIQVGDGDFINLQPGGTAFCVHNNVQNSVYREVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PS23</accession>
    <name>V7PS23_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PS23"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="128" mass="15059" checksum="709017FD3C822DCD" modified="2014-02-19" version="1">MDNILYDLYKSCCNFKTIHNINTFVKNNKDKLNNEELKILNENKYLSHSISIVAALSIQSAFYRLRRLKLFIYRKTIPHVCGLLSSCFYLYLHNLYISRNNISKLIILAEKDTHNTGIGHIIKDMLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>V7PS37</accession>
    <name>V7PS37_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1335" mass="157328" checksum="3708728D1DF832F7" modified="2014-02-19" version="1">MNKNKKKEKLKRKKKHTNSNLNLCKEINDNFTKLTDKLPNNKKEICNNNTNELGTNNNDSSKKIIISSASNSHTPENVQCVNKEGEKKKGGEKKGDIVQNGDHADKHVDEQNGDHADKHVDEQNGQNNFEIKSDKVTDKGKINQHDDISPPVLKKIENKKTESKENSKVSKDEIYNLVNLNNMEEIEKNINYIFPSINFDNNSNSNKLECIENVKNDDKKFEDEINKEIKKFQKDIKDVYFYHNNLKKGMKKNKCVNYENNMNHLNSTSDINLKNIILENEFVNFSEILIKGNNFLNLKKKIIKKKKKRKKKKKKKKKKKKNKTKLRTQNYKLIKELCLSYDAYTKETRQKQRKNEKKVRKYYIFEYSCGNTKIQSITGYIICYKSYEFYKNDINVLKIKPKEGNIFGKEGNIFGKDGNIFGKDGNIFGKDGNIFGKDGNIFGKDGNIFGKDKNIFGKDKNEKNISVLLCVNVSNCISPSGFLELLYPCDNFIFFLKVLNKKNSEEYMIYFLTFNIYTKKILNKAKKISFFNMKKKKKLKIYIVKGITMNVTSCITRNTNSDSYIKTNKFYNIDLEKKTMCANDDNDNDNDDNIENLQLISNTNLISPFYLISQNKFQLSCAVCLEPLYSVNLNKIISHIFNFSFKKKYSSKNKYNKEENKLQTYPSKYYYKNLNLLNNYNMNKYAYHLSVTNLINNLQNKYNNEMKKEREKNDKNRSKIFNNIPINILCSHIFHSSCLKKCCFTSCPICRYKQYNYEIANCDICKKNYNSKICLSCGFIGCSFNYDKIVKIKKKKIKEKKYLLKKKKNIIKKISYIFRKLINSFMPIFNTIILSLYYKSKIKCVYKIRTKQIYIPKKKKKKYISTNYNHQTNYITYYSDNHNKNKKIINYKYPNPQNNNDTQNEKTTNNNLSLFSNNDNIYINDLKKFYKYIYIGKSANKKKNVSYYFSQNINKCIIKKDAKKKKNDNKCKLQNKFGSTNAQENNETELKKGMRNEMGKEMRNEMGKEMRNEMRNEMGKEMRKEMRKEVGKEMGNEMRKEVVNEMANEMRKEVVNEMANEVANEVANEVANEMRNSATNVVVEKYTKCSLKKKKKKIKDHAKIHFYKTQHNYFFDVRKNSIYDYSSDIYIKKLINLKIQNKKFKNIYNTGNIYTNGNNSNPNKEIINKKNIILYIYDFNQLLNALLESQRNSFLSCIHDLKINYENINMDNLNDINKCVKEIYILQEKNNNLKNEIKKKINILIDKIKTNNNLSRELKNVETINAKLSADQRKQIYNYDLKNEQKKNIIKEKQQIIKELNKQITDLNFHKLASSKFSQNSEISVMLKMCISSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PS49</accession>
    <name>V7PS49_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PS49"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="506" mass="60520" checksum="D222A4BDD75B68B2" modified="2014-02-19" version="1">MKDSLLSQILTEAEIIELGLNDSLMRHCSSPFILNKKNYIQISILYLINIFFFFCVYITIIVFRIVAYKPEFTTDISLIIYVYIFIFFYIDLIISNDIKYNLVRKYNIKEVRKRIYAKYLSYKKRHNNQIVPTLSNSNNINHSNSNHNNNSNNNGNGNENGNGNGNGNGNEKKKFINDKLFSREKHFIICDNEQNETLINENINYNEDKYYVLDELKNVNHNINKELLKYIQFENNNYTITHHKFDIFLIIAGIINQLNTFCDLLFLFSIYNHSQVLFFISLFIYIYYLVYFILILKFAVNVSFTLIEIYRKSLYRSYKKFIKKSKKVISYIKKIILYIKKIIYKCIKKYLKFIIFIRGDTIVPTENVPNLFLNKYTCYNSWVFFYKENTDTTSDLQNLKLIYDTDFEDIPKKKLKKNYINRNRKNEMRTKDMSIPLVEKNNIKFISKKKEKTNYEKALVPKYVQMVADMSSILSFYHILNIMKSKFLSAHNLYSHVSFTLIFFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTS9</accession>
    <name>V7PTS9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTS9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="647" mass="75672" checksum="76F4C3FF5E80FF40" modified="2014-02-19" version="1">MRILLFGDENFSFCNDFLAEHENDVVEVCSCLKENELKQEAKNNIQELSKNIVIHYGINPVQLKSKFAPNSFDVLYYILPGLSFHGYPDFIDPQTEMFKLRLNLFTFSFLKSSKNIIKPDGYVYLLYPEENQKIEGNSAETTASTANNETESINDNNENHIGEGKDNDSEKRKFNLPFLPIEPKKLAKFCNISREYSKDYYLNLSNHEKWLPVLFNMPIVNELPEWIKTCKYYCFKMTENTSNKNNSANNSPQENRENQIKEENNVEGEENKENENDSKREDEKRQDDNDEEQNENNGSIENTNKNDENYNEDEKEKGNQSNEKTKENGIEQVKDKEDPDEYNVLKIPPQVFDYPIEKLGHVNECFLFKLYSVNSKSVLISRLTLKYDPRISGWKGDNKIKKDMMNTSMGMNMNNMNMMKNMNNLMNMNKFKGGKYKNKQNKNDFQQQYKNNMMQNNMVYGLNKKGNVNLPPPPPTNLNMQANNVNMPNQNMNYKQAKFPFVNNFKVIPNNLSQNVQNTMTNMPINVNPNISNNMMNPYINGGYNTNFRNNMYQQNMPISSPMGNFNKKMYQGHNMNIKRKNDSFNCDSMEKSYDNFNMKENYKSDDDNNINTMNAYNDDYEHDKFDNSGNSKNIHIKNAEDPDYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTT4</accession>
    <name>V7PTT4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear migration protein nudC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nuclear distribution protein C homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_01408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTT4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="8">
        <location>
            <begin position="159"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB61533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="283" mass="33769" checksum="3FE5C3B40FD15CE0" modified="2014-02-19" version="1">MENDKHENMLMHIARDFKSIDDLVDVFLSFLENKTDYFHLMMNDDDIQTLSKKYDGDIAKAILNNNTCGFKANSRETELMKLFRKHQLKYIIKNQPYIIENEDIRNKYLSPCDELNKLSNIQIAKTKNTQNEAQRNNRNPHTPAYDSINEKHISTWNGGRTEKYFWNQSLNEINLEIPLNKEIKPSEIKVEITNKHIKVQHLNEVKLEGMFYEEVNKQECVWNIEDKKKIIIFLEKKKENWWSYVIKGDPEIDTTKIESKKNLTDFDEKTQGEIRKMLYKQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTT7</accession>
    <name>V7PTT7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Erythrocyte binding antigen 175 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_00610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTT7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046789">
        <property type="term" value="F:host cell surface receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.20">
        <property type="entry name" value="Duffy-antigen binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.170">
        <property type="entry name" value="Erythrocyte binding antigen 175 region VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042202">
        <property type="entry name" value="Duffy-ag-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008602">
        <property type="entry name" value="Duffy-antigen-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021620">
        <property type="entry name" value="EBA-175_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043057">
        <property type="entry name" value="EBA-175_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05424">
        <property type="entry name" value="Duffy_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11556">
        <property type="entry name" value="EBA-175_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140924">
        <property type="entry name" value="Duffy binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Duffy-antigen binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Erythrocyte binding antigen 175 C-terminal" evidence="4">
        <location>
            <begin position="519"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB63006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="76995" checksum="B61EDF49F421ED02" modified="2014-02-19" version="1">MDYFKQFIYKDAAREGELLLNKYDDKNNNEYCNDMINSFGDYKNIVEGTGLKNVANESLLELKIQNIFGTDDNAKRNRKTWWKNHEHIVWKAMVLGKNFNETSNYKNVCTNYKLEDYHSQIERWTREWIQEFSVQYFKEANKINNKCTKKSNISTESICINNECKNACNTYEAWISVNKSKWDTLLQRFSQFNKSYFSEETCRDKAYNSLMIEFKEAYEANFENVINLDDDHYTGLCVCSSVKPSNTPINNNLGYKQTLETQNPTDASQNTLFPPFSTGTETDLFKEDDDDNGGFDLLSYNNADAQNLRNSTPTDQVGVNNEQNKLNQNAESNNKYELQIMGNHANSDNTYHNIIIPSQENNIYTSTPESVTINPTSTSNTNENQTLTPNSTLTPTLTSNSNPTQIPTQPQPQFPIPPQPQFPIPPETQFPIPPETQIPTPTLNPNATNKGVKEHHFNTNGIENGNTMKDQMNIPPIKFNIDPKHDNTINGGFSRINNDNDSENANKLGINEYEHRDIKKSRENIIMLANENVCNGNPGLKYCESINNKYFHGTCSKSQTQNLCCSISNYCIKFFNINSKKYYDCMNEEFMAPDYNCFQKESYSNQYYYATGGIIFVIIFICASIGFSGNKSEEEAFNNYEEYLYKSYNQSTLNNGFKRVQEYIPVDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTU8</accession>
    <name>V7PTU8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTU8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="138" mass="16091" checksum="D5D14BC0E181C7B8" modified="2014-02-19" version="1">MGFQYMHLLYFAVRDSVSTLTRENITFSKTDQLAIPNSRGTANFLVKWTEYPKYSTINFVNTKKSCSYDSTSNEWQDFATFECRGIEIAEFIPSGDFIIEDTQGKIYYNVNLLDLNWCDYNQDHEMCVGVYNLEHEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTV1</accession>
    <name>V7PTV1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_01421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTV1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00164">
        <property type="entry name" value="S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050437">
        <property type="entry name" value="Ribos_protein_bS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF10">
        <property type="entry name" value="S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="616"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="783"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB61548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1131" mass="134823" checksum="F97FCDBE7260576E" modified="2014-02-19" version="1">MIFTKQCLFLSFFVLIVSSFLKRKLVLNNYIYSKTNRFKKRKKIVNYQLVKSKDKDVESYIPHIYKDIAPSLKGLADQEYSYKQLLNAYIPETIEREKRDKLNKKSNQKNNKKQSKENRQTNKNNEIDEKEENEENECNKDLSNNIDKMMEIKMKENDIKHFENLSEISNHKKKNKILDIAYDVIEDTLKNTYMNQKLGLDNENNDSKKDYLEIAKKRKDLLYDKLINNYSMLNNSSTFDLFGVFYDNNNYKDDNKLIEELDKIMNLEPFKSNKDNIDEDIDALLKKDKIPTHIRNFILKYKNLRKINMSNNKIDHMKKNENEQVKESGSIKQMDNDGNVDDEKEKDEENRNYEKNIKDENGENIYNDFNRDLNKVLMTFNKNLTNEKLVKRDKYIIDELYEEYKKHIKNMNIKRNKLEPQKDNYDFLTFVHEYGEEFFFQKYGYFDNYLKENVEKIKNKVRSENANIVSIPNIMNSEPNSKQEKSSTITKSNDPVNNIGNEKDNIDEDFLNDSPEKKINKKNDEKNNTQMRNNLDWRKESNKLESYMLSNIVHEYNKRIYDIYKPNDMITNHYGFNNYIDNEEYDKDINVSLNKYSIMNYDSKEELNNDESLYVGKLIFGKIFKIEKNMALVDINYSHYGEIHSDQMPYNITNISDVFKVNDKLIFEIYKMYPNRIELTLKNIQKINDLNKILLYKTQDIPFEVTVLSIIKNGITVSYNDIYTFIHISAISSKYKVIVDENETIDSNLLNKKIKVFCTDINKLSFSNLLYEQNEQLKNINMYDVIDVEIIHISKYGLMVKYNDIVGLIHVSEISRKKIENINNVFKINEKIKGMLINIDYYNKRFSLSTKILETHDKNFIDNREDIYNNIEHIVNNIKKRSNKMEVNDSNIKNQLLSLIDIYKDGNGSEKVKTEEGKDETTNQHKKIQEEIKLYDNEKIDKHPQVTSEKTGSQTEHITDIKNDNNIIDGEEKYNVNSIDNDIKKMQEKYQNNDDDTLSELNQSEEKEELSIDVHNELVPYLLLKQSDSNKEEHEEEKKEIVWNLDDEEFLHSNSPTQNSQYIEYQWSYLKDKKWVSFPYHVNRIINYYFNINDDFFTYKEKTVTYEIYFAKNVRIDLSTGLQNKIRKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTW6</accession>
    <name>V7PTW6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTW6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039879">
        <property type="entry name" value="EFC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="83" mass="9937" checksum="87A79311D01555B5" modified="2014-02-19" version="1">MNEDLEYIKNKKLSEIFERLLGYIYFKKPQNIVEAIIQEVDKLEKEKHVKNVFDSEDIKSMYNFLNVENNKYMTKEKCILGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTX0</accession>
    <name>V7PTX0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTX0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB61568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="106" mass="12750" checksum="2D53E9469571BA1D" modified="2014-02-19" version="1">MDNILYDLYKSCCNFKTIHNINTFVKNNKDKLNNEELKILNENKYLSHSISIVAALSIQSAFYRLRRLKLFIYRLLPIYMLKILKSSFILLLLFLNKLYFLIFYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PU41</accession>
    <name>V7PU41_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Symplekin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_01507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1375"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1399"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="4">
        <location>
            <begin position="1802"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1715"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1715"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1741"/>
            <end position="1751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB61653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2000" mass="239155" checksum="0D94229AF8D8D454" modified="2014-02-19" version="1">MLKIQKKGIAKIIQVLESNEESEDVLITNINEIEQIFLKCFRNENKKNRKTINTYIIPYISILLERINDGNGYNDNHIFKEKLMIRILTFFFSLIRINKNYSYLIVSYFVNLIEEKHYLVKVIEYLKKTIIYLLKGLLFVRASLYNDIDKTIENVDGNPPTVVFDEKRHEIEQIKEGFHSYVILKSKIFNILLNYNFEKYIKENPYKYDIIKNLMLIFTKEILYFFHILRNKKNIFKEILSQEKYVHHIINEMFDITYLNDVSNKVNLKNFDEIILIWLEQNIRLFNDLILFSISKHNNNIGCLEKKTNTQNSTSMFSFPNVMNKLKKNNNKNNKQTCKVKKESNEICEDEAELENHNKDTHKMEFVNKLIYYFEEKKNSVSENELNNDDDDDNIKNKKQLLKDEKKKKNNDMGRNATYDYVDKIDEESCEKYMMYENIYYKPPNCNLDGKEEIENKEKIKYLINEDCLISNINEITTDNIIFLTHLMRNIFYLIRIDPFILNFFIQNLFALIKKLMFLKDSIQNTNTYASCNNPNKETGKKGNKKSKKNEGNNEIKHSKEELFDCLLYYIKNELSILICKIDVNFPFYYSYITILLNIMGIYGTTEELKEKKKNLLNSVYINKELDKELYVEDDEEEDKEKRKLQGNFHINNQYLQNKNVLKKEGYGYKKLRNEQVDIMSYLKVKMNENDSKNRNFKKEEKENIFINQVIKKLYLTNFNLNKKYYEQLKCFKKINLVDIVKDSKINPINGETKLSQEYYYSNNHSNILKDIKNEEATSRLRKTKNYTPHICNDNTNSKVNITTQVINKYDDEKKMDNEEMKEENNKRGYLNNMQNMETNFVDLFYKDIYTQFLNSNLKYYGNVKNNDTILGSIELYYFLLFSQIINNNLENNVQVLGENIFIKKINNLKIINNIVKRIILNNMMRENLKFFFLTLYIIKVNSTVVFTDTNKSTFLNYSLIFKMLNNILFYSYIQEKSKMDKNKDTNIEHPTETEKNLSVDYKTNCKKTKPDYTLGYASFCYNYLNQIKNKLKNNEHVYRSELQKKNYKFKCLYGEIFNIIIYFLHNDNLLTNNRDQYIKTFIEKILETPKLPFTFFIYLIMWLNNIHTHIDYKGYINNTSCDDLIRGKNENDKNIMNKIKISKNLTDKNMEESKMETNMNDTQPPNYINEFSTHENSEINHIEKNKLIKDNDDNNEEINVLSCDQQSEGVCSYFDVETEEIEIETFSNDEAIGIDVNIKEKKEDIEDSLASDQEERDIDITSYIKRNEERLNKFSCDEEEIKSKRFNINYYIRYSYRSESSSNYYIFSFSLISNLLKKNNNIKSKKTVLAIYINTLYNSNNEIKTLLKKLITASKGIYNNTLNFYVYTKRIYNFYHKLFILFLLYICNIYIPHLKNDILFFSHFAFYLWPIELINFIHNFLIENFSFFYNDLLAIFSNYKNIQIYEQNMRSLKNFQHIQQKLNEYTNNIDNPEIFQTLEAFLKETDFFNTTKEETEEKKNEQENKIKDENIINNIEEEKECLQKNEISQKILIEEIFIFLFLKTINLIEDNKLFEKIKKSNIFINLVSIDYVNSLCNFVISNIEQLYEKNKDEFWTQFSSLLQEGLLDDIKIKTSNNNTDDKGSYSDLREIITFVINAIDNYLSICVKSSMFFHLYLFIYNNCVKKGIRDILLNKFIKALSSLKSLYHEEIFRILKYNNKINYDESENVDIKNSDIKSGEENGKTNKDNIVEDEEKSEAASVTNEKGNDDNSYINTPFHINIEIIKYISKRMYEHPSHPTEEAHINFLNFCYNLYLENNNIFFIIELIGFLKKDQTLYIFNEIIKNEMDENKKIEILKTCIDNIIKLPYSYVMEKQNENESYYITNIEIFYFYYNLNKNKNIQRIMLDYFVTKVNLNQLDDQENNKMTNDITIKDIANIIQQIAENTDSIFPIYGRFLCQVTKNINILREFVSSIIIPLLIQKKIWTNKFIWKGCLMCISMLWPDFKHSLFYIFFMLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PU47</accession>
    <name>V7PU47_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_01509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PU47"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB61658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="49682" checksum="A90776D955B8DF83" modified="2014-02-19" version="1">MKTILKYAKKKNSDQNEITNEDDQTTINCISINDININDIEENVITRDNNNENKKKKDKKIEYYLFDVESYNSNNDTSLNSVIDLNSIKSHYLPENKKKNAKKKASNYIKKHVKKYKKKYKILPEHNLDQDTSYEESVKNEKKDYDTYELKEIKNDKTNIDFVPSQKKENLSKKNNSFIDVIKFVFLISCIFSLGSFSTTITKYIFFVKKFNYTQIVSFFEFLVMFLILKTFIFFAKIKSSTSLTRKQYIRYIVFISALLGLSAISGNSAYSYLEIPVISVIKSSSLVLIYFLSIKFGLKEFKCSLLVSILTILMGVIMSITTLKIDSLFGVFLLIIYVISSSFKWVFTDILLKSTSMKAHIILLHIYQISMLIIIIPTLLIDMPCIINDYNNNNLSIGQILSSLGFVSLGAVMSIFLILAEFSLICKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PU54</accession>
    <name>V7PU54_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type ATPase, D subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PU54"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26011" checksum="CD0FCA6FD683A8B7" modified="2014-02-19" version="1">MKQKKKSAFQGYSLLKKKSDALFIHFRDVLKDIVKTKNKVGEDMRNASFALAKSVWAAGDFKGQIIEGIKRPVVTLSLSTNNVAGVKLPIFQVHIDPTVDVLGNLGVAAGGQVINNTRENYLQCLNMLVKLASMQVAFFSLDEEIKMTNRRVNALNNIVLPRLEGGINYIIKELDEIEREEFYRLKKIKEKKTENLNNSIEDHALPDNGGHKHVKITNNYANIQADDDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PU61</accession>
    <name>V7PU61_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_01516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012331">
        <property type="entry name" value="Clathrin_H-chain_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="644"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="1395"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="1543"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="1692"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1872"/>
            <end position="1899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB61673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1948" mass="225579" checksum="8BBD0EB849CD355F" modified="2014-02-19" version="1">MSSNSPISVSLVDNLASYNIQNESFRLGNVSIEGDKFICVKENVNDNTQVVVINLYNQVSIRKYMKADSVIIHPNDPILALRGSIKNANTIFLQVFNIETKEKICSLNLNEHINYWKWINNDTIAIVCEKNVYHWNIDMYNTKKNKENNVLTKVFEKAQIFIDNNSQILYYGTDKEMKWCILCGISTQDQGKSIDGHMQLYSCEKKLHQIIEGFIGCFGSFIFENWDTKSLFCFIEKKKNSSMSRLHLMDIYNSKTEGSTPYKIVKEINLINDTLNDFPIYISLNTLQGVIYVITKCSYVYIFDESTLTEIVREKISDDNIFICCDNKNGEGIIAVNKKGKIYYITLNYISLINSLKSSNIDVKDKIIRNLSLKYGYPGCDYISVYKKCISEMDFKKASKIICLLKNPKIFEKYSNSISEAITIMNKKNMDIRIVSPLRTQQVLNSFKTFRNSQGQLSPLLLYFSVLLELDKLNTYESIELVKPVVLQKKKEYLEKWIKDDKLACSEELGDLVKSLDLRLSLIIYLRCGAHNKIISIYCLLNMFNNVMTYINNYKHITNFDFVNIFITIINYEFPTTSGGGSFNSGNTNGNDSGSSLDLHHTEKNESLDFFNDNNSVSNSKDLKNGNNHRNTNIEIATQYIKLLSDNNIQLDIGKIVDYLLNNNKLQEATSILLDYLKDNKPEHKHLQTKIFEFNLHHNVQIAETIFQMDIFTYYDKNRIAYLCEEKGLYQRALENYTNINDIKRVITKSACFQKNGNISNNLNSEGGSGNMSLHGGISLEWIKNYFSTLSDSVCQDLLFDFMKGNKVNIEIIISICVQYYNKIGIKKIVNKFEENKNYEGIFYFISSILNELQNMGTVGNANDIGKYNDNNSISSNNNINNNLSSSRSNNDDTSSILINSDIGIGTQFPYENNSVLTIEDLHHIMFKYIEACVKINNIQELDRICKDRNAKYNPEQIKNFLKECKLSDPRPLIYVCDIHNFIEELAEYLYKNSLLKYIEVYVIKVNPHNAHKVIGVLLDLDASEDFLLNLLNNIKNISNIGNLIDIAEKRNRLKLLLPWLESRSNEGYENIELHNALAKIYIDLNKDPETFLKNNNFYDKKMIGKYCEDLDPHLAYTAYERSNGQCDEELINITSKNGLFKLQAKYLVSRQSMGLWSMVLDESNKYRKNVIDQVIGSTLIESNNADEITVTVKAFIEKKLSSELIELLEKIVLHNSEFRDNKNLQNLLILTAIKSDSKKVMEYINRLDNFSGPQIAEVAYEYKLREEAFVIYKKFNCNTSAISVLLDNILTFNKNRKGALSSSYNEKPDGASSIYGSNEVFRNYGSGQLSEFEDENNEEQEMEKDETHPNIENYEEDLNRAIEFAQKCNVNDVWFILGKAQLKLNKIIDAIDSFIKSNNAGAYKEVIEKCKENNFYEQLITYLNTLREQNSLKDVLVDSELLYAYAKLKKTLEMTKFIASTNLANMQLIGDRLYKEKEYDAAKILYSSIPNNQKLTFCHLKLKEYSLAIEAAKKTKSLKTWREVNLVCVKYKQLKFAHIAGLQLIMHADHLDEIIKIYEKKKYINELLSLLENGLNSERAHVGIYTELGMLYAKYKPEKLMEFIRSYTNKMNTRKLIDVCHNEYLLKEAVYLYISYDEYNLAVDTIIKHSPIAYQPDIFMQVIHKVTNSDIIHKVIDFYIEENPLNLYNLLKILENKIDNNRLVQTMKKSNNLPLIQKYLEDIQTQNITSVNETLNEIYLENDDYISLRKSIDEYDNFNQTNLINKLENHKLAEMRRIAALLYKKNKKFKEAINLSKKEGQIKDAIDIARVSKNHLYVEDLINYFIQIKNKEALCACLIACYDILKPDYVLEIIWLSGFKDHAMLYFIQIISDYTQQIETMKKQIEDIEKEKKMNKSAPNDYSANTISNQFTYSLNKNLSIMPPQNNYIPNNSDFDKYDMFNTNTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7PU71</accession>
    <name>V7PU71_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell cycle associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="2051"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2308" mass="276425" checksum="A0D592D4E92E25D0" modified="2014-02-19" version="1">MLPSSQQIIIGKLPLEVKGGENNTYLKSDNNKKQCELKSLNTNENSLSKMEKENEEEFTKNNQIVLPNKYDEDYVKEQNTIFSIDQINLSRNSLNIHDIYYIYDEETEISDLIIKRYKENHYLTIFNNMLIIINPNKNVKDFYKLLFKNKNKNNYIFKLFMNNIKEKSIEEKYENDNINLQESSESSDSSYRNEQKKTYDHINKNISYLNTKELINFEILKKRKEKYRKYISTIRKNLFINSNNEVTDTHSDNLKKFATLFNISLEIGKEKYTISNSDSINSDIDENYINYIEKKKKWDNIHINNTQNDSYRSNSVESKQISYEQLKNMHNNRKIVISECKNKLLFIHGEKYSNQYVVNNYILKHIIKDENNKELYYSYKNIMSILNLFFVNKCFNFIIYKCVNNKIIYFNIVPCFLSEENNNVTNICTKINEFYNQLIDSEKKTNSQKKVAKQMETKEKKKSNHNNETTHSPSDKESNGNGTSIDNDNNNNIKEKIIDLRKIINIPHIFFFLLKCILNNNNHRFFKDLKLHTLDIKKICRNYIDIPYIKLNSFDADKLFSSFLKIGFSEEDIININKIIFAILFINIYIRIRNCLILNEQKALNQLQIQLIQVQDYIKLRKLHINNNENMKGKNTQLNLNKFLNFNYKNYVNSEQSPHSEYGNNNISKNKNSEKKIKSNYFIVFVGHILEEYISYLLSIDLCNFLDILNDTIKLTNFCSAVYFRLKLKIIKQVNQYLNNRHSTDRNINHIWYIYSNSGVMYNSMDQNYNENNFSKNNNNEIEKYQHVCNENKLSSLSSLINNIYNEIIYSYYIKISAFNLDICTVQAIKNIRNKRKSYEDATQDSINKYKRIKNKLENRNLNNSYIYKCKKNVILYLLEKYTHKILAIIEEDMSHDNLNINNNILTKPRYFKLIYSFYLSIKKIMQHYSGIINKLKSTKKIYSKISESINERSDEHKEIDNEKSGGNDTRQKYYSENYIRKVVNKIITDINKMEELNNKKYKDNIITNAKKSNFSIVHYNNDNIRYKCNNMLLDNFKDLCSLNNTIDIIENTEMDFFKKLFLDKSIPLKFFKNNLMHNEIIFFLYIIKNCYERFYIYLINEREKNKTDNSIIFSKYIDKNKNLYPQFSIINENELSSSNNSIINNDNIQNRNNESISDKDSDLQDDLIVNKSYKKYQKKEKTDQVGKRMESYLSFISYKQINDFSELKKKLNKKHIESIVKNLHLKTIFKYQMQYLYYNISYMDFINKYLRFCVYINTDGSLAKLINWYEEKFEKTKENYENYLPDGSSLNAIDKRLNEGVSKKWKETKIKNIYNSTNNSQSSEEYIQNYYKLENIPNKDKKNLCKIIVHYLNLTKEDVYYYNNFVFIKKRYYFILEHIRNEFVRTISPSTKKNEDFWLTYKNQKMKNFYTNKVVKIQNYIRKFLNSSKMNKIEKKKNLLVSFLIFYSYIVKNRNKGETREDLELYKQKFMKEEKEIIRYAASVYIQSWYRKIIQQRKYKALKIETYKKKAMECIYNVIKTYIVQIKTIAHINDVIIPNRCALIIQTHFRKHVCFTDFRKKLLLKICFLSIKRKYLTYSNIITKVNYHHLAKNIYNRNNIQSLLKIPKAVIKIQSKYKAYIVRKQYKMLRDAIYFTQAYIHTCLESIKYNNIKNSVILIQRWWRSFCKLKKVFSNVQLNIYSNEYDKRKYFFLSKDNFPFYNYYTLKEQKAMKLLTYNILLKQWYFFYFKKFQKKNHIFNIVFNLKLYKNISYHYTLPWAYKINTILKIIYMKQMFQKCTNNNQNTIFNIPVFESIQIFIGRTHTILLIKQTTSNEQIPWNANKRNSKNYYHTFVYSIGSNEFGQLGYYNLFEKNFIYNINNTQNEFNSMNNDEENIDEENPLEFDDTNKYDSTLEENKTKKKNLENGDNIILKNRMDSTITNSSDITDKNYKKEKRFDNENSSKEYIPYNTEKNKKTKINSLSNKYKKNLQHLIFEYKDKYIIGTENFYKNQEDKSINDIVDYKIVEKENEKTGEMEKVVQFTKVISETNKIINICCGSEHTLALSENRNVYAWGNNAYGQCGHKYELNVIRYPKIIKYFKKNNIHIKNINCASYHSGYITETSDLYISGNFFFINLKYYNQNLYEPTFLISDCHNILCRDNFNIALKTDKNSLYLWGNNYKCILGINKEKLGNLDEISCYPLSIISKTIVVQKIVCSENFVCLITKYKTAEYSLYMWGEFTLIEKQTESDTSSIKSNTINIFNKYKIKPIQRNTDEQIKKKKIKNKKILIAKPSPVYNDVWDSLDAIDICCDLDEVLVRLNSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PU75</accession>
    <name>V7PU75_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="896"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1491"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1567" mass="184945" checksum="863589101C1EF25E" modified="2014-02-19" version="1">MELHKLLENKLSIEESQNINTKEGDMHLNTINEDKKIATEKGCVLKIKNCDNEKENLPNSSYENINIKKKGNDLQYYNDQKYDTLNNALTTSESFNNIKIKKKCYEKNDDTINLDITSSTENLYHNINYDYIDKQVHNLLESGNSSDEQGEIIKDEKEQIKTKIEEDEIENNEEMQGLKHIEGSLLFSSLSNDEFMKIEKNESIPFHSDEIDFICEDEMNNIILSHEQKISTFTSLLNDNEKKEEDYANYFRGRNENSIESYNGNGNESFDSNIKTGKSTKECGELDSEDDKEIKNILNILQNLRDYNFNDTNAIDNDDNYENMEEKDELNNTEHSYNCENEDNSNTKHDDTIIHDKNIPFLGTDYIPNDIASNKKDINSTNDQTGSDEDKDNIDHLNIKKLKDKYKKYVFSLSDHDEYQRSDRSVQSQNGEEPIEETYYNSDTNIKQKNESDKCQEDGNSSNTDNIGENQYNYKHISGMSNIDMNETPISDSNNNFDKMKNHKKKKKEETIEENELKEINELQTDSYDKENPHNNLTNEENLEYYNLPVKPNVLHIESQESWQNKISATSDCIIDSKHSSVSFYNHEIGSFAEIEKERNDMYTKVGNTENNNNNNDNETKDETNNKKEIEETWKPSEIKNDIVNTNKSSKNEENENSEQMRKRKLIKENINNLRNDNKNLKIIDELNQNINNLNFEYLKNNEFNLDINYTNDTMQNVSIQKNNNISEKIEKVEITNNNLLDENLNFDYYLKTLHNLKSRIHQEISGNDSSSNSNSNSLNKKDITINEEKNENKAIQNSDEISAKKERENDNNQNEKSRNTEYKEITNNNFQKEPNEPSEKKIIKDKHQDKEEEGKEIVLKKKVKKKKKTKRQHSLDNNEKDVSQNNTQIELVEKNIILKNTVKDLQNQITNYKKMEKLFDKNKKKYKNKLAIINEYEKKIDCIIIDFNKLKDKCTNKEKKISKLEEVTKYMNEQFSISKIQFENKMNEYVIFLKKKDSEIYMLKELIKEKEKVISFNENILKQYKADIDDMLKQNIERVEHVKNKLKIQQNMISEKDLKITKLEEDIRVNDAKINAMENKIKALQNQIELEVKEKNELKKNYEKENKEKDALSKKLDEIVKEKNNLHYKIEELLKTEKNIIDDKAELLECKNELSIENEKIKFEINTMIIEKEKMEEKYNLANSKKDQINIEMEILKKTYENNVNELEKLKEDFKNVQKNYNQLKEEKDRIEKSYSTEVEEKNKIQNSFEATKNELATRENQKELLQNDLNNLQKYLDETVTKNEEEIKGLKKQLSELEEKLEEANNLYFKEKEVIEKLNKEKNKFIKEFDKLKNKNKKITSKMKETQISNEKTINDVIKEKNESLEKEKSKFTEKVQSLEQAFQESYNELHCQKKNIQNELEELKIINQDIKNNSKNLLNVNDALVKEMKAYNIEKEQFIKGLKNIKEAYIKIKNENQQLKKNAFSFIQKDIEQNYVPINIHNTVLNEKKTYISEIDILKSKVKKSENDITNLSKEKSELSEKLKKINQQNEDLNTNIKVKSKITEDIMRTVEVSFDKFIHNIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PU77</accession>
    <name>V7PU77_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PU77"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="280" mass="33247" checksum="87EF013EFD2A1E4C" modified="2014-02-19" version="1">MMIKLVLFILLIQTYYTFHINYKILRNNNNPNFVQKIKFASNSFKHKNIYSRTYKLSSFISNYFTNEGDKYALNDEEKNYLKLLGRSDNDDYKELVKSHEEFLKCCNDIKQKLKYKDIFFFITQKIIKKNLYEFKRNNTLNIFSRDNYTSELSLDYIKTSNIEDRIKEQLIKKFESKLGIFEYLSFGIFKRKSILEIINITTLMLPITFIGLLLSKMGLFSVAVNSLLTAHFLTFKKDQKKKMNISTFILTMLPILLHSSLGIACNNIFLKNYRVIILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PU80</accession>
    <name>V7PU80_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PU80"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF613">
        <property type="entry name" value="NUCLEAR RECEPTOR-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="283" mass="33611" checksum="0E064E341192BC4C" modified="2014-02-19" version="1">MGILCSSNEKYTKYFHRGYLINPDTNVNDTTDLYPCVFLRSGEKRLVKKIDKNKFKGEILNSLLKLRTYTYKNESSLPKYLLKTYNIYKDDKFSYVIFENCTGGFFFDILKGNNVINENILAEWFYQILITLNFLEKRNIYHGNLNGYCIHFKDKTRKEIRLSLLSINNYYDNIDEKGDLYGLYCIRSPQEIKKLYHDKNNSWYVGMLLYFILHGSYPFINNNVLVNYHNIIQNNIPFAALKLDHKNYSNLMYDFLKSALEKDYDMRPSVEGLLNHPWIKSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PU89</accession>
    <name>V7PU89_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PU89"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB62197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="158" mass="19030" checksum="C8BFE97E8F029443" modified="2014-02-19" version="1">MVNEINVFFFKEIRNLNIYENVKYSNIRILLSIILIIIGGYCCIFVNHKNEPILMIQFLAAFFSISIILYIWEYFYFEDYFMIIETNDNKAVKLFLKFDIKTSCLILNYKLNKTVYSTPFELMKLYNEQGYLMEDYARHTLKQFISNHGKNFKLTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVU9</accession>
    <name>V7PVU9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation elongation factor G, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_00096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVU9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04088">
        <property type="entry name" value="EFG_mtEFG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001532">
        <property type="entry name" value="Translation elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="105"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB63260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="905" mass="104371" checksum="01485EF8C7EF7DC4" modified="2014-02-19" version="1">MIKIFLSKSYKGLDRFILVLFLIFTIVGANGLNNKKRLSQCKSIFKHNRGGKSEGIKLFIRNKYFNKNNDLLSKYRRKCNNMHKVNIFRLKLSNNHSLKKNVDLENYRNIGIIAHIDAGKTTTTERILYYTNVIKKIGEVHEGLSTMDYLDIEREKGITINAAVTTCYWNGSEKNLGNYRINIIDTPGHVDFTAEVEKSLRVLDGGIVVFDSSEGVESQSETVWKQANRYNISRIIFLNKLDKVGANFESCIEEIKRKLNKKILILYVPVFEMSNFITTIDILKEKMIVYKNAHDFYFEDIPQEYYGIFLKYKNLLYEQIAENFNAFLDNYLNDKVMKVEEVEYYIRKLVVEQKYNVVICGSSLKNKNVQMLLDMVVKYLPSPIDCIQNYKNQIIYKYDVNKKGEKIILNSKKDEKSICEKMDNVSIGNDINGGVNSETNKNVTSGSNNIYDESVNQVINHKAISNTLNSNEKNEKDELKQNDLISEELSKENIKDYNRKFVGLIYKIMNDQHLGNINYVRVYEGKLNKGDFIYNNRTKKSEKVSKIFFIHSSEKYELENAYAGDIVGIVGLKDTQIGDTISNVFLRTELKKIKEIPPIISFYIYNKNKNEYEKLINALIKIKKEDHSFFFHINPDTKDLLISGVGELHLQIIINKIQKDFNIPIIYGQPQISYKETFIENVEARGKYIKQSGGRGQYGDVHIKIEPMYNYTEEEDKEYDVNNNNDDKKEETNDDMDKNCMNIDTSEVNNNIIIKNEITCGAIPSVYFDAINAGIREQCNLGVLSNSPLINIVIRIVDGSFHPVDSNEHAFKLAAGLAIREAAKKTSVRLLEPIMNINVTVPTEYLGEVISDLVKKRGKIQHIDESDEYTKEIYARAPMASILSYVSDLRKITKGRGYNFWVLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVW2</accession>
    <name>V7PVW2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVW2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008536">
        <property type="entry name" value="DUF818"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05677">
        <property type="entry name" value="DUF818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="24026" checksum="8F7E1BF6042F7E8B" modified="2014-02-19" version="1">MGNILNKIIFNAPHEGIYEKLDIDFIYIETEDNEKIAAHYINRNNLLTVLFCHGNSENIYMLYDYFYEVSEIWNVNILLYDYPGYGESTGVANEENMYKSGYAVYDYMVNTLNIKPETIILYGRSIGSCAAVDIAINRKVKGVILQSAILSLFNICFKTRYILPFDSLCNIKKIDMIPCYVFFIHGMNDKIVPFYHGLVIKIIKNENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVX8</accession>
    <name>V7PVX8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acylphosphatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVX8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="2">
        <location>
            <begin position="91"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB63290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="176" mass="21234" checksum="3E3287D2B885C6F8" modified="2014-02-19" version="1">MIPTPVSKKIRSRLSLSVQKKPHFLFRQNLLLEKKDKWEPKLRKGHPEFATQFDILNRQVTGFRKYKPPLVKKEEIKKNYDITNFHEVKSKFRFEINGIFEDGGSVFCDELYKTAKRMFLVGWIKCRRKFVMGHFQGDSYSISYMRHWFDIYSSEFNKIHNLKIFDENHGIPKFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVY9</accession>
    <name>V7PVY9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_00474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVY9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="209"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="422"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB62792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1029" mass="122853" checksum="BA5EA2BC815FDF08" modified="2014-02-19" version="1">MFFAKQKKKDKKENLTICHRRLGIFKKKLYKNNHQLIYISLSGHVYTSPDYREIADFDNDILTKLKISKTGECSSINNIKFVYETVNDLNKIDKFIHDEKNFEYYYIPPSIIRKYNEIKIYELYDEQIECLRNAFENEYIESNLNDKKDDIIYDATHVQDINEILNSEFFSAFENFGEKGEMVKCLDSNVMPEHVQEKNMNETQIKNIQNDKEFYKNFLFSMPTGMGKTLIYDIIIIRFILYKGYRVILTLPTVSLINEKYDYYEMLLGNSTVSLNIKKFNSFNFTGYSYSLSTDIALCTYEQANIIINIIIKNNLKSNFIFIIDEIHYINDLQRGFFIESLLTKIKYAQKNYNHIFNLRTYGFSATFSNIDHIGKWLEAKIRVSSKKTQKIKYLYKIKNVMYKDIEQKYIERTLDMPYVLDPDHLGYILSEELILKRNVLIFCSTKKQSEKVASFISNVISYYLKNNYFNISIELLEKRKKLINQLNEIKDININILEIEKLIINGIFYHHSELGKNEKDIIENALRNNILFCLCCTTTLSVGVNFNVHTIIIRNIKIGISFLTKDQIIQISGRCGRLKKKNDENNNFTIKPLHSNNKQINDSFYNEIKKHELTNKNNYYIKDYDTNCDGKVIIFLNGKDDVEYLKMLFQDDGEKKTIKSTMENFDLCKFIIELIELNIIKTKKDIIYFFFLYALKFCKYDMETDQIKDKDFPEKYKENILLEIKQIFQYLFDNKLIIIPYEKEQNYYYYIFEKIYNVNLYKIENIFNFNFLNQYININIMIKSNLQEKICLFKNLCNHYKSNNILDQENEKCTIPFITILSIFKDTHINKNIFPNLFVQFIKYLFLININNKQNNFYVYDILEEDDDLTCSEISPYVHPAPTSLDFIFNYSIIHITYVKGFSPDTLLMIFVFCLGSDINLKINFEIYESALLQNNDQINALKIFKYLDLNLDILQKYKMRKNENFKEVSERFLKGEINIEEISQTFEWVKIKRFYFSLIIYDIFNTDFYTVSRKYVKFYELKNCFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVZ2</accession>
    <name>V7PVZ2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVZ2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB63305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="512" mass="60882" checksum="C36F97245ECBBBAB" modified="2014-02-19" version="1">MYVTVIEPILQSQSFSETSNINEYDKNINNNDYNNSQYQNLQNFLGENQIISDQKKRLVDFQNELNEKNKKFDVFSKIIYMENIPEKYTENDVVEFFKNVGKTTNYKFLYNEQINKHTVYVEFINEENAKAALNLNGTKIEDKEVIIKDAYSILNQNDSTLKTQLSIYNNLNKTINNDKNIINKKNTVNEKVEKVLALKEKLTLKLCAMYNPNVLLMNNLMQSNQLLLANPLNNISSNNNIKKEKEKNDKNESDLTISQKEFKSDDKKNDDKKTDVDMSDDEKKKYIKKKQKKNTKYSTNSHSSHTTEESDEKKSDQISSKSQSSKSRSSGSSRSRSSRSRSSRSRSSRSSSGRSRVRRKSIDKRHSSRKRDKIKKRSPSSSSNYSKSDPPSSYDSGKHTDRYKYQNQRHKKKRRKNSKGNYDSSDTCSHSSHSSKRKHRKSNSDKPWWIKESEKMEMRKRMKEKYRREMLYRHKHKEKSRYRHRDRDRDRDRDRDRDRDRDRDRDRDRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PW60</accession>
    <name>V7PW60_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_00968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PW60"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19821">
        <property type="entry name" value="Bbox1_BBX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049808">
        <property type="entry name" value="CONSTANS-like_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717:SF45">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="5">
        <location>
            <begin position="228"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="5">
        <location>
            <begin position="285"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB62383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="499" mass="58143" checksum="930FFFE9B7691467" modified="2014-02-19" version="1">MNNFVNMCANLCVQIYMCQTYMCASLYMHEHFHGCLFYWYSLPGFPLISLNKDNLHNNSYELTYEQNGSNEDKKSLKKKIMEQSENILLSGERGIFEFFVCDVGVGLSLSVNENEINSYDRDILPIEYDSIFIKKNVKNNNNYYENSGQNGGTNLVDSLTIHYKNKENNNNNNNEKEINLALGGDIMPSYGVLPYYTFNHEYIIYDSSQLLPRYLIQFECDPSAEELFSIPLCDYCGNAPSLYYCESDEVKLCEKCDNIIHSQNKLVKKHIRKTLNEAQSNFGNCKIHLQNEVNMFCTVCHIPICNLCMCSHAHKDLSNVNFFNFNNNNSDTIISLKMAYNAIMQHSSKPSNFIKERKKNLNNLLEKIDKLHEQVRLNMNETEKNVYNVLEDLVKQLHTTTDKKMSSILSEEYELKRQFNEIMWNENFLYYLQTILPPADFMNAWLKHCQYREEIEKNSEHSEKINSLIFPDIRIKGNINVITEGSINHENIFHSSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PW80</accession>
    <name>V7PW80_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="1497"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="1677"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1360"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1887" mass="217169" checksum="0C07E54B833DBC47" modified="2014-02-19" version="1">MENFSKKFFPSLYKRNKGNENQLSSSTNNNSSNNNSNNSNIDNNNNINNSNNNSNSNSNSNNDSNNISNGIEQNYNTNEKYNLPRQGIGTTELLNADTSGFQKKNQDVNENSFTDLAENCKREKHMTTLEKSKSKNRENKENRENKENRENKENRENKENKNNGDISKDLSKSEIKSDDHLINDSKNRKDQNSKVNLKYDEKEATEEDKQNPTVRDKNKKDAESKRSQENKKNNINKGKYDEGKYDEGSEQVENEKKKINKEKIKNRDKDVKDDNSKTCTMDDRNISINGECIENLNDSENNNDNNNGNNNDDNKNGNNNDDNKNGNNNDDNNNDDRKTAKKIKMKKIEINKKENDTSGYSPINNDLNNNNNIMVNTCDKIIKNENNIENKSVNIYINTKNQNIIFNNNDNTNIQIIQNKNNLTYYYSGNNNHNSYMTEINNSKKYNNEFESNTYKLCNATIDTNESNTLQTKIQNIYSSNNNINQNLANDSILKHDGIKETFINNVNYNNFPNHANMNMIDTIENSSPILTTDNSNSNSNNNNSNSYNSNYYANMFNDLNYVPRLNNNYISQNTNDNTLPNEADSYNNFPYVNTKIRTLGNNALLNGHRNNVKNRYNCISDNNNINNNKHNTNVINDFFVYNNINNVYKDPVSNNDHLSNGNTSHYSGQNFEIFSMGMNVDENNMHASGILDNSYTYMNPFNSDNTFTCKNLDNLVNSNISMFNGNITDNIPNRYVNHANLNFSIFNEKEMNPNQQTNDDFINDVNYDVYSNYTQNNHSHNNSSYTQNNHSHNNSSYTQNNHSHNNSSYTQNNQNNQNNQNNHNHNNSSYNHNHNNSSYNSSYNSSYNSSYNMPTNSRGSFFPNHNVNFSLERNTFLNKNSTASFVYNNLKRDDNINDIYDEKKKLFDVLNSAKSSIIIENDLINNNNFSSSFETSNNPEKTKSGFIFDKNIDHSKKKTCTVKIKKVSALNLEPQSGLTSYGGKTENSENNENRENSENNENNEKCGKGGCNKPNKANIFDVAKKKKYVAEIIRCELIWGPSKNKEPITPVENCELHPVVIIKDELGNLYDDDEDNENNPIGKTVNIFYRWSRGPPRTVCFFHSQKIGHIQCTLTFRCFCSYNCFMKGFEDIHKYYKSNGSINIPSHFNLHTYGVSCSSFNWENYDENIEFDETHYKGLINSGLINVSGKETWKVIHNERNYIPCVKDVGHQIMLETMILDKRAITSTSKTDSSDSSDHSENSDHSENSDHSENSDHSENSDHSENSEKLANLKTDSIDNFNIIKERTNIDKENKISISQNNITQINKISETNNTDLTISNVDDFQVSSTMDTIEASLAEPDTSTRFSIPLISLKESKKNQLRNINSDESTEPRFSEKEPLNPKPLNLDEKKNLVLTTQNELANKNKKNKITSETTTQNELANKNKKDQIINKNNKKKKKKIYVLDDNIWNSINDPNIYHKIITGCCIPNIQIMPNNNNITSFKTLNSSDNQFTVMTWNILAEIYGTSEAFSHCDPYMLSWSYRKTKIIQEILNYRPDIICLQEIQNEHFLEFFKPCLSQYEYQGAYKQKTKEIFTSPSGKHKGGKYTIDGCAIFFNKKKFNFVEIYALEFSKLIKEGSVISLPKEVQKNPALSKGLLKDNIALVLLLEYVENNKILYDSEKWEKNNNPHFENKKNKKNKKKMVIVSNTHIIANPEATYVKIWQTQILVKVIEYLKINFIQKYEIIPSIIICGDFNSTPNSAVYQLLYKKKCFPTHNDIHSDEHGLLKYLPMSHNLNIKSAYAISNFLSQRINKEESINNIIINNTIELDKFEPAFTNYTSNFIGCLDYIFYNDEDLNIISTVNIPNETQLIQESQIYHLSTSALPSPVRPSDHFPLVAKFEFKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXZ2</accession>
    <name>V7PXZ2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXZ2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="471" mass="55657" checksum="5D10BDCE598DFD7D" modified="2014-02-19" version="1">MHTYIHIYIHNLIYCLSWVGTLESNICIINSFHDLSSISCEDKTYESCSDSSFIYQNLNENFNLYKYIKENNNNYKKILKNNLDIYEKKYVKEIILFLENILKLLIEKKTKESMLIFQGKQIQENSNQIMEKKEICFSNSSEEDNEEIIKNYEKYNYNSLDETDEQKDVIHSNINKKEMIPSKKGISINNTSDNNVEKNETDKNKLLYKKKNKIYSVIRSENISPNFVSNLDTDNSIRKKDKNIDEENVFENIKKDTNTYNDLQTIKLFKNEEKIQIKEDIIDIEIDKEEDENSDDIFETIFKFYITDNQIKNKGNKKENINNEINGDKTKGMMNIELFLTFTKNYKIIKNLLTKSELEKIFINECKGNIYITLKQFKKILNICGQIAFTKPPHKNNYTDTKKIYSLLISWLINNSPEHQKCKLIKYIPLNSCTFLNDSNKSNTTKSRDAKHNIFKSSKSSISFKDKYKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PAF3</accession>
    <name>V7PAF3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PAF3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="868" mass="102675" checksum="589413A2496B9C07" modified="2014-02-19" version="1">MPFRRFVVFPFYLAHPSYLFCSLFLCRENLVRLLCTSMSYMNKHIKNNFHKNRVNLFKIKNLICLKDYNDFKKYEDGYYILFSFPSNINNDTSKRILSSFLTNKKNVLILTKKNKKNKNNSICSDICDHYYRNKKSEKNEKSEKSEKNEKNNFNFSYTKNVKVDDDALYEIYLKEKNNIENYILKNINETKKKKKKKEIQDNNGQEKKHKKQNKNLIFESNEEMIFIKKKTKKQKNKKKQTHTITQTGNNYLDNIQKDKSSNMFLKKENLKEESFFEFFKNKKKKDKQKNVNTDPSESSASTEPEEEEEEENEEEEENEEDENEEDEDDDEDGDDDEDDDDDDEEDEEDAGNDDDEKFGENFDSYKQAKSEIRIKRELNSDEDKYLNKGHKFLSNKIKVEKIKAEKIKAEKIKAEKIKVEKSDSDISNSSQKDDEQNWENKFIKYNNEKKKPKKLYTNLVGHNQYSGMSGMSDMSNTSIISKKNSWKNKLLKYFKTIPTISKEETVSIQINCKIKIFDIEYIINQNTIKTILFYLNPKHFVLLPSCDSYSSFNFEMLFYSSIKNLTKIHTFYYPSYTDTIKENIKNLLYERYFFRNALSIDSVKIPLNLPYENVYIKNIYTLINSMIPETNNINVFKAKVSITPSNQRDPNLPPNQRSKRFINEHSTFWNEYKGSEYTLSVIEENEDIEKVGIFSKSIQNKRDDNKIEEEKNKENSDENDEKIKKDQNTKFFNYYINDDEIENKSDGSSDDTSSLSSQNEEDLYIQNKINDEKKLKGDIYIGDVSIKNLLTNINKFPNICLNFVNENQIILNGKASIKKENIITLNQNEETHLSTNSNNTVWRIESSLDPSFYFIRNALKDLHNNMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PAH2</accession>
    <name>V7PAH2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_05404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PAH2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="3">
        <location>
            <begin position="61"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB56556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="170" mass="19242" checksum="37B2A67AB85D6654" modified="2014-02-19" version="1">MKPGFGLIGNNLKNAAFNCFTNIVYKNKYLTNVVNKKLMKMSDEEERAIAAAGKDENGDSIFGKIVRKEIKADIVYEDDKVLAFNDINPQAPVHILVIPKIRDGLTRLSKAEEKHKEILGHLMWAVAEIVRKNNLGDFRLVVNNGPEACQSVYYLHLHILAKRQMKWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PAJ6</accession>
    <name>V7PAJ6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_05565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635824">
        <property type="protein sequence ID" value="ETB56418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635824">
        <property type="protein sequence ID" value="ETB56419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PAJ6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB56419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="419" mass="49396" checksum="719B55571C60F345" modified="2014-02-19" version="1">MSFFQPVELIRKRNVATQDFKDYLFQFKVVKRENGNSSIKSVCIWKEYVVIGYNNTVSLHNIKGEWLQKKYSCKENVSFLKFRDEKMLGIGMENGNIELIGVFFFDKIKNLKGHKSSITDMCFSSNFQKLYSCSRDFTIKIWNILEAKCEDTLDYHIDSITSMCMYIKNEDNYLISSSYDGYIYFYNLNKNESPNKLELKSPIEYIHIYKDKYIFVAVKNVIKIYSLENFDFIKDITITAKTIYFLNSFNKYIVAASIDKTVYFIDPQLKHPEKIKVVSIFTTIQPSKAVSMYENTICLGSSMGSWSIYGYCESEKKTINNKRKHSIINLEEEKYRITNKNINNYLKRFKYNDALIEAITYESSSMLSLIDYLSKQNMLFAACSTTCEERILKILKFFRYKFVIDILMFEFLFSFLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCK9</accession>
    <name>V7PCK9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_04969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCK9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB57139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19858" checksum="F0F319FC4D580C8F" modified="2014-02-19" version="1">MKNKKLPVLFSITTYLASSITSVFVNKYMLITNTLDTIFLIFLQHLSCLAFLFIFKNYLSKIQKEDDVKNEFFSLYQGIKHLWPLIISFNFTLIFGNLCLKYTIISFYQLARSMTLPFNFIFSYFFFKHIKFNFIMICSCILVSIGFFIFSADAINTNHKAVIYGLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCM8</accession>
    <name>V7PCM8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_04984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCM8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB57164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="306" mass="36668" checksum="20A10CB097C6DFC8" modified="2014-02-19" version="1">MCDKDGELYALKKYEKMFLEKKREFQKKTKDNKIVIKTKYDDLKNELKIITDIKNEYCLSCKEIITNNDEIYIVNKYMENESILKYDQCFFIFHPNESYFIPIPVIKCIVTNILKSLLYVHTKKNICHRDVKPSNILLDKNGIIKLNDFGDSEYMINKKIKGTRGTYKFMPPEFFVNTKCYYGEKVDIWSLGICIYALFYRVLPFSNKSGLINLFQEIANEEIKYHIDRNYFLSKVRKDATKKISHDSLSNEDINFLKIFLKKKPTERCTIKEALEHKWLRDMNQRDIEEYAKNVYKKKNIFHNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCN0</accession>
    <name>V7PCN0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCN0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="74406" checksum="94C940E1C334CDDF" modified="2014-02-19" version="1">MDNTQKANIYNYVNIYFPENIKIYENTSKCFLYGFSNSSTYAAIYVTPNYIKEIEFEMNHEQIKNWESFRILGELMFVKNYDDIEKYVNSKNKKDKINYIYSIYYKNKPIVVKINTENEKKNSVLFILYNTNKYIYNFDSDHVNSLISDAYKINFASIYYNKDYHKKSNSILNNSNLNNGKTKNLNIGSGKCQHMHTTSCGDSKRCDSEKGKKSYDLSKNKICEHLLIRDVIKLINLRYVYIEEMEKYENKNNGNIPKNIITPKFIYIIYIWLFFMYIISVINKTIYYLFYIPYIFSEKFDSKNKLTILKLIKDKCLLNSEWYKIFLQIIKNKKKKNFYIYYKYKQILLIRAFSLLLDVLGGIILFYIISIQIFNLGFIYDKIKTVFETTTLTSILGTLLQKPFGIKLNNNFTSFIGSVVVSILDKWEVFKNLIPFKRNSIINFFNISSLLGLSIFLSLTIDYLRFATVHVTIIFFFFKKIFSIFHSTMYSLYLLFNGKKWNVLKSRVDTNYYTNKEVILGTMLFAILIFLFPTVVILLFVFGIVYFAIKGFIYFLVVLKEIILYSPIYILLLRSENKYISQYTKENELNDFPQSHYLLLENDKLLFLDKIKLFFAIFFNYQNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCN5</accession>
    <name>V7PCN5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sec16 Sec23-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_04992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="10">
        <location>
            <begin position="704"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1127"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1134"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB57174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1382" mass="156008" checksum="F5BCC7F780F3B72D" modified="2014-02-19" version="1">MALKSINISGNFDWCPFEEYKNYLICFNSHNLLYSNNGSLNNYTYLLDINLNNDIRSLDIVHKLNFEEALNRENNKSSKTSSNEYVTSFEWINCNNFVESQNENELNKGIIVGGLTNGNVILLNAQNLFDTSNGINYENFILSQTNIHESSINCLECNKHKNNLIATGGNDGQLFIIDIENIFCPTSYDPYLDKNNLQKITCLNWNKKVSHILATSSNNGNTIIWDLKIKKSAVSFRDPHSRTKTSSLCWLENQPTQILISYDDDKNPCLQLWDLRNSNYPIKEIIGHSKGINNICFSNIDSNLLLSSGKDVTKCWYLNSNNFDIYNEVNNSGNNIYSKWSPFIPDIFASYTSMDTIQINSINNGNKMTNKYIPTFYKKDTSICFGFGGKICLFDNIKSDNSSNLSASENVSNKNVNQMNQNNVDEGNIQINKNKGLQNESGNNNNPYLIKCHIYPTEVDLIEEADKFEKYIACGKYQEFCENKIAKCDDYHEKLTWKILQLLCTSQKEEIVKHIGYDMNEIHQKIVENVGEESGFIFKKYKCETNENMNISGNITSNNLEINSDVNNKHDNTRMSNLNNGENISGYSNYGNNMHGEFVTSQMQENEQSFNESYDLDPEKFFRELGEKNEIEKNQENEISKEDKNGKEKLKDSLNNVDSNTKDIINTIKCQNFENVLGEINEDSKPNSNKTNSNNWNNGIESIIKECLLVGNIEAAVELCLYQNRMADALLLSSFGGENLWHKTKNIYIKKQNDSFLRNINYVLDDNLECLVKTIDLSSWDEALSILCTYAINNPNFNNLCEILAKRLQNEKFDVRSASICYLCASNFPETVEIWDSMPSSKSTLLNALQDIVEKITVLKMVIKYNKYNSTMNQKINQYAELLANSGRLKAAMTFLSFIEDDKSIGNLTLRDRIFNSAAHIMPSHIKPPPSPFQYFDIKPFGLSQKYNNNNNNVNASIQGIYNKSQIHPNKSLTSIVPPLPMSEMHKQHGPSTPMAPFSHNSPTKFNTQMIGGSSGVSRLPPQKDFMGSTDSTSNRGYSTSNFNNNVKYPSTGMGSLYIPPPNIPSHSTTPINASPSPYNSVQNLAHLPSHPNLKLEHENKLGQVSNMFESQSYTNVNKAMQNSMGPPPLAVTPPSNQIQGVSRSSFSVSQNNIPPPFPQRNRHASVSTPMGNPIQPNVPFNQEPQLNKREPIDSQIYNPVSPPPQQTQVPTQMQNTFTPQQSYSQNKIGFAPPSGIKTTSPVAGAMSITPGMPVPWPIPTTTQQLGSTTQSTANENKKIQTVTKEQNGVLMNRTNIENVKKIISNLLNMYTSQEPVKKKADDISIKVHELFDKIDSGAFSEQINTILINFTNSINENDFKTANKNLMEISRNLWDGNNKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCP7</accession>
    <name>V7PCP7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_05396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCP7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB56547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="524" mass="61610" checksum="A57FE22CFC5E8E59" modified="2014-02-19" version="1">MNNSKFVKLLSLNLDRNIDNNFERKNDFFCESDISSISSYDEIKSNSLLGLISINSFTNDSKNSIKSENLNPFKRVHSLNEYTLNYKKLWSEKSNALLFNNIFTKFNTNHNQIYTLNSYENSNTILSWKYESSEITFDSEPNDISKKHSCNFKHNPSNDNIDSFIYTDTFNSDVSKQIKNRITNNESPLSFYLNQIQNYDLNKFNQDKNTLINSSQFIKINKEINKTDFFKDTKEVIPAARKMTTNSPLKKNATNYILKYIRRYNEYINGTKLQNYRAIKKMLQKIRKACRSIMVKKFHNKNMIGLLMYMEKDKKVMKLWKDKSKYLHKKNKNKRYFLQLFYYYVISFYLKKNSLQKKKNLCYMDKCIAKILFQNKYKEINTKTLSNNKTNTNKSYVLGKLNQNIILGKGNSIFPGSTILATTAKIYIGDHNLFEDNVTIINNTNKNMYIGNYNIFRSGTHIINSLKIGSNNYFDYKSTLYNCTINGCVFVKANILMNIKEIENRNPYFVNSTITNIHPIFIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD02</accession>
    <name>V7PD02_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PD02"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="308" mass="36308" checksum="62E2A5B382B356F6" modified="2014-02-19" version="1">MNKYFSFRISIMDNKRCRRTFRISNFQTVTRISNKWCTMPMVLNEGWNILQINLSDYTEKAFKTKYVETIELQINASIRIRCIYFCDRIYKNEELKDEFKIFSKKKEKIVYIPPQNLIKTLKKNTIKNAVKEKISKKENEQECKDENNTSKPGEIKDTSLDSTKEEASIINVPQTMVEINSTENKDKEIESNFKREDDQNIQTNLEKENKTHDYMDMAEGLENYTDKVEEIDMIIKNDEDAHSLSKIIEPLDDEENNSTMDPNKTLLVEGNDNEADINNLTEIKNIEMDLNNVLYEDTNYDTYNNDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEM8</accession>
    <name>V7PEM8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEM8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="2">
        <location>
            <begin position="172"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1085" mass="126434" checksum="4C228D1C2FC691FC" modified="2014-02-19" version="1">MDTEPSSSLSGKKPSLLSLFTKKSNLGNQKDTEIENLNEQVLSEKKDDSNDTDCENENIKKKKVGTTLNKIEETSASTKNEKKTDTKTEKNVEENTDKVELNVQNDGNENTMLSSEENINNNGETDQVCLEGEFENKAEKNNIQKYESKLNPIAPEFKPQNSLYIYQKIQQHTKRNIILLIKSFGYKGIKLEKISGEYCKKYNAVLNLGQAGFTNIYDILKSLNNCLIYEYEEKEDGYNNNNEKKNDNEKKNDNEKENDNEKENDNENESKTDVPVAKSNEELERNLIIKYKTPKMNEDREFFVKIILGTIAEYTNYDPKLSNEETPLNNNLSLNKLPQEIKKIFGQTFNIKALQIRCGIYKLQTFLEEIQEIDIFSLSNDIKIRITPETYNSKIPQLKNIKKSMTSNELKIKSLYSRFSSKNISNYNQYNENKTNIKLCDENSNIIKKTASQNNDEKNIQNKIDKLDSIEIIQTINSRNNSISRKNDFLHDINSSLYNSKSCENNWKNLFLGQNNNQLFENQDLSYMNKTNSIDKFEDDYIDKYDTKFSANFSRFKNTHDPIIYQKGLVNSHPNYFPQFKKDNENKNLLPKILPKAQLHILLFQLIVILSARQKIEWTEINKIKEQILRSGNETNESEESPNKNETDTKSTVEEPESYKKEKTNILDILNNSGTTVSSDYLNGSYKTQDTSNMYKHEVLSSDMNTKNSHFFNSNELDDSENELIGVFVSSIKSEWNKTYSEQYPLSFYLNYYKTKKLKKLLEEIPNLIIAGYGRTMQVITLDSAQEYYDNLFSDDQNNFKAIAKSKFTSLSSALYFKDATYKEIAEECINGDTSNVFKILEINYIKLSNSNKNINNYNFINNENIGRNFSKSMDNLIDDYNLNENRDKYYGHKNYNKKKNLEILRYHLHKLLYNLVIHVCKKQNSLFLKYKENGIILNEQEINKQLCSPVFYPSDLTYDDFIMPKQNFIQKYNIAKNMHILSQYGIYGIKLIHLPNEWFNLYKCELRPLMKICNYYQIGKMISTMSNLLVVNEGFDTKYIPNTNLDSELGSFNDLSFWDSVKKTPDSMLLHECPKLNENCYAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEN1</accession>
    <name>V7PEN1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_05007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEN1"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB57192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="129" mass="14976" checksum="F472D78C7DB6DAC3" modified="2014-02-19" version="1" fragment="single">MINKIKGIFRVLYNYATLLLVYGLIIQASYLCFKYALTFSTKIRIACLISFGFTTFMTLWCHIKCLLKNPGHLNKSDFPGENINIYDHNISYCKKCNFPKIKRAHHCSVCNKCVKKMDHHCTWINNCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEP1</accession>
    <name>V7PEP1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEP1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="164" mass="20313" checksum="78678134AB17DD3D" modified="2014-02-19" version="1">MYILVTIVVQYSFYHVRHLLNNIRNNIEILRCKYLLKKLKREKLDDQRNMYLSDNATKIQKIFRGFYSRKYIHNYYKWKENIIEIDRYVKDQKNKMLYEIEEKRIKQLMYDNKIKDIKIHNVAKNLHHLISTKAQKGVYNYKIENIIKNQQEKIINKVKRDDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEP4</accession>
    <name>V7PEP4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEP4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="842"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="627"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="842"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1037" mass="123824" checksum="25F52AE9A36DB9C6" modified="2014-02-19" version="1">MERCKSYEEMKMKMEKLKILEKDNLKICNDKKNDEKRISELKDKLTKEENKIIELKKKNYYNVFKLKDFKEKERDMIGEIKKLKKHIREYKICFEKNRKINKNQLKYMKGKNKRLLNNIHGINFELKKCVSKINKINKNTESLKREKENVQKEIYFMKKKNEKLQQELKEIELEKKNKESKAQTLNSNIYKVCTELNKQNKEYKENIKRLCCCKEELKEALKKKSCKFILLKKNCYYLKKKIQKQNNELKKHLNIIKKQELAINNCSEQNEKLSEELKRHNSLIKSRDDKIKILENNLIKKEEINHIKIKENANAIKNGEIELKNINEQREKLHEQNKKLNELVNDLKSQIIKEEIKNTEINKNIYTIKNENKQIIQNYEQKLRDKETYIEDIKNELKNVREKIEEKYDLHTKENKKILNSKIEKMTNEINELNKIKNSYEIEIKKLNNDWDKLNSQLKEKESENENLANSLKEQENVIQNLRNKIKEIEECEKLELEKIIKKMQEENEIQKEVIMQKSNQDKIEFEEKIKSIQEHNKIMIEELKTKWKEDKENYEEKIKNINEKNNSIIEQIQEDCKSQIKRVTDLCNVKTKSEVNKLNNDEILQKKIQEYSIMLNNKDEEIKNIINMYNEKLQLQNTEMENLINECEEKLKKAKINKKQISEKDNQEDITTSDAAYRVGEREARVTEREKKVKEVENKVKEREKKVKEVESKMKERENKVKEIEAKVEERENRVKEIENKVKEIEAKVAEKEVRAVEKEAHLIEKEATIMEREIELKEKEDKINKLQEEINEKKKMFNNTQLNTSNNVIFQENKSENIENDLQKSTTDFKTNKIEDINKKVKERNETNSESTENEKIGEENISDKNRNIKIEEKKEKNKKKKEKSKNGKKGEKYNKDDLLTLELLEEKYLNVQNKLIEGETNHRLYLKSLIKTLDEIIEMLNIKQSTTLNNQTVNSPPLNGTLLNDTTISDAINTINFAISSWNIFGEPTSTNPIENTQTLGENINSISNFDEKNSEDLKNIVTEKLQLIKQIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEP7</accession>
    <name>V7PEP7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEP7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="200" mass="23959" checksum="416DDEFD7FA78EC8" modified="2014-02-19" version="1">MQRKQIYTYIINEDFEMTHKHICLILRNEIESLTCNILIRLCNELIWIINSQKNNNDIKKKCIRNIFYCANKLNIGNTESLRLYMIKYFGNKFIENIETDYIILDKNICKLVNKYTFTRQEIRDMKNKLQDEMSIPINNKIKQCFCNFCINPQTSFTFSKLNKHENITSIAQQYSHYAENIYDAEKKEILAEIEKKLILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEQ1</accession>
    <name>V7PEQ1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEQ1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="687" mass="81705" checksum="6CDA610C3F3CF728" modified="2014-02-19" version="1">MKFAVIFLKLLVIIVIIIQEISLSSCIMLNKIFLWVLDSTFIITISYFLFRSVNNIHIYTIYVYSIVTKITIIFFVSFPKYIMNKNHEDILKIDYYDIFSYKIFLVSTCILLLILVYVFLFYIINFSFLNIHNINNENSIFFVIIVQVTIDIIDISHFFCSSYFNFFLYYFRLKGEYYIFNRLNLFLHTSLNKQNLIQFYTNTLNIYEIMFIIYGVFISLNIFLHAYSLPSYSYETVIQKKGGAISNTITRDHNYCINNPEVYFIHFSPLNNNPLYNLNEYLNQKIFNSNSLEGREKESSQKNDIFLSFQNNDNTKIKQNNKFQLNVGGDATSCLKYITIFRLLFTDIPFLVARLFNFVLFLDAHAAQSLFVVKNICFIIINTSRIYRNSKYYNKNDNEDNKMGIRKESEKICSDESEKNIYKFIGNESKDNNEEMKIEEVKHNFEKKKKTTSLLKGSIINKWFKNSISSKKKIIKKESFNEKVNIYKINEASYNRPTNIIYDKIQKYYYFLYIKYNGINLKKNISCYVDDIKTNSIKNILLFIFFICLIAVKITIIAIIYAFNFDNQLKQNLYQITHFHNIQNIELSLMLQIIFIIISVYAIFVFLINFFTYSLFEAIFMFILYISNLLSYSFVLFILSFSPPSYNIFVYFTAQKDILLILCVFIYEKCCYEIYNCPIHIFGYKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEQ4</accession>
    <name>V7PEQ4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apicomplexan specific coiled coil protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEQ4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28785" checksum="8C58CA56EC524392" modified="2014-02-19" version="1">MATNQNAAMFSSDLQTFIVTKYDPLLTIVKELNDKLQNSEKDKYRLEKRIIKLEKQMVILLDKLEVTDIVLDNNDMPEKKTQKINYQIENDENLLAPWLFSCQLGTPLSSLQVLLEFSVQTTIELNVKLWKREEDMWVNFLEAISNKSKNYLPETLDLLDLRKSTRKCLLNLCTNENLIVLRNVPGKAQAVYNTTTMTLVAILASAIYEAWKRIELTDPVSLGRIVLVLDGEDVGSRLRAGNKKLKIEPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PES5</accession>
    <name>V7PES5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PES5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="207" mass="25612" checksum="7881428651CD57D4" modified="2014-02-19" version="1">MTNYFMHFIYVNKYAYAQFVGFVFINIKTQFGTKLNKYSASIFLIIGRVINVEIAKRNEPHEPTPGEYKGVQNMLKRYPMRHDYYGRRYDPHFDRRKYDSRRPNPYNRDYGKGYGYRNTSFRQYDKYNRNSYEHRHYDRRSIDNKYHKKGDYYKRRSKSSDDEKRYSRDDSRRRKRYDRTRKSTSVSGSERHYRNSSIDRSSFQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PET9</accession>
    <name>V7PET9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PET9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16015" checksum="BD60D5B6533BA6D5" modified="2014-02-19" version="1">MTGTEITIDNIAYAKIFMHALKNSYNDVCGILIGKYYNSENETKKCIISNTIPLFHTHILFAFLSLAFTMIEKNCKESGERIIGYYHISADDSKNDNISNIKICDVISDTLIKNYNDALICLVKISKLKDDEDNCIKVTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF02</accession>
    <name>V7PF02_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635806">
        <property type="protein sequence ID" value="ETB57337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF02"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="157" mass="18362" checksum="48B105060D65D9FF" modified="2014-02-19" version="1">MFQGGDFNFGNGYGGESIYGQYFRNEKFIYKHSKRGVLSMCQTSIKHTNNSQFFVTFKSCPWLDKKHVVFGNLEYGFDTLSYIEEQATLIGKPKKQVYIYNCGAIPLDKIKYKSRTNLNDDYIIPEVEMPLLEKEIGFNENSDINELKRIYKNSKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF07</accession>
    <name>V7PF07_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_05301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF07"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB56948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="123" mass="14733" checksum="C91A8E2E575DFBFC" modified="2014-02-19" version="1">MAHFSNFIQKCQFEGCRYHDFLPHKCEYCELMFCELHKKAQDHVCSKLKHSDLKKVILCEYCNAVIPDEEEEIKWHLIHKCTYIKKATKPKICDKEKCKTVKNKIDNYKLYKLMCQIKNTLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF10</accession>
    <name>V7PF10_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Condensin complex subunit 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1470"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1472"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1526"/>
            <end position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1536" mass="181846" checksum="B96F3E04A83C053F" modified="2014-02-19" version="1">MNILLTYLIYKNDNYSNYACLICLNMLKWMHIERKKQMFRLFTLKGILKRFLLCAHYLNDKEIMKIKKMENDQSISEDIGVLKNIFMLLYESIDYLDISNLVNINSKNCIFELIKFYIELLKYPLIHSVHILCINYLIKIVIKCYDIRFEYNINVELYDIGPHVNIFVKIVNLIFAKILSILKDIKNSENVYYIEEINNINNLIALLFTNILNSCIRIIIPQVLYNDKQKQKYLLNNEMTRTTKINKIKDDELDAEDKIVLNACNPVFSFIEIFIINNSDKYEKTVFTDLIKIIINNCRKIEKKYNVMKIIHDEFMLHIKGEDNKKNGDKYLDKNYLKTKKISKKRLESTASFKISDECNSSVYSETEGEDEEEEEDEEKGREDGKSEMGDNQTNGYESEKETNKYCPVSKIKNKTKSTLEIDNKKYCIVYESVMIRYLNLLLKYMNCEKHQIRNMILDLFLILLKKKKTNKNENIYEKLFRLFLERLEDPNIVVKSKALSILVTLTNKKHHNNNLVRNFIYNKRKEKINMYKIISSNIFSHRSNIRKLTIQYIEVIFETLISQKLNYKIFLIFISNYLYSLSFDSILSVRRQVLLTVNILFLMASNDEYIGKLWITIILSAITDTEETIKDEAISIFINTFMKASINCSMFNTNEKKINQVLEENGMTYFKALTTFSHELKTKKDDYKNTKSDVEVNPIVKNGSITDSVTSDTNQRKYSNNIIKNKEGLEKEREECDKNNDGVILLIEIWEKYFESNMDNYFLTLLKMMTKYDLLNFNLILLCLTQKKNNVLEEFIKGINIFIYNLRYFSIRTWNTFIFDFIIELSKEYQNSINFESILFLLSRCYKIYLMNEKKNINKSNIIDKNIMAEKKIENIKENPEINNTIKTEFLFDSILTDQELANEKKSCPNGILKNIMLKLFTIISNLLNNENNEVNENFLEIIENTIFNFNCPMCFIYIILNILIKKKKNVNQFIDKLKNKIHFFFEKIEIIPYNNVFCNILVTFIFLINHYKKQDTEFLTMASEKLKIVYENVCKDKSAGSNETAIGGEDSDNLNHLGENIIMVKNCIYMAQCVLIIDKDMMNKSDFFLTLEKDLKNSNTCMNILNNLIILTYYMIKNFGSSCNKFVFNLLRFFKHENSFIRYLSFYMLSKLISEDYVKFNNQFFFGFLYLLADKNEIIRKQSLSVFKHIVLIYNKSNLINYMIDFIFVLNNFYSIKLSKHLIHIGNHFEIKNPEDRYKIYCLLIENLTNSEKFSFQQKLINEYLIQYVYDYDNYYFSDEHAKEKKGDDGINTRAKHNNIIPINDEGNEGSVLKDVLLILSSRLMKIKIKKDFAKLEEKNKNIKIKNVESSVKVLNDLMKNILKKNTLPILLSLRAIMLKTKSFFFKYINNLIIYLCIDYKDSLEELILEAHTRNEIFSDIQHFVYTDVIHSVHNNNDIFNKNSNINIDINFLELSQNQMIEHNLEKNMHNKNIRKKGNIHKKKNDDNSDDTSDNSDRSSDYEEVSNVLHSIHNRHQLSNNIKINKKTKKNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF32</accession>
    <name>V7PF32_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF32"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="34798" checksum="9E00A7D518BEFAEC" modified="2014-02-19" version="1">MIFKRFFHKYPGGSKIKCYVEKKKKKIINASLFHQPLYSKNSKCLIDWRYCTPKSGYEYMYIYGENTIEITNLPNNKTNEYIQERLRKSLNKYGRLKILRCLSHRNDPYINNNVCYATFHNKKDMYKCIRNVNIRFPLSLQNKILKFKSLYNDKCNDYHYFYKQEHYNYSAINVALNLFKYLQHNNCFINIKDIYKHVFEYSYYNHKIVSSGISIYKVFNKWEKFIDFFDNLFIKTKKDNQIIITPRLIDDKNLCIYLNNKLIDLKRKTNSLNSVYWRQDSVQLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF33</accession>
    <name>V7PF33_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fam-a protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF33"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26710" checksum="EDA4AF3FB4041019" modified="2014-02-19" version="1">MYILINDSPKEIYEKNEHLLCTDPEETIKADEVMNEALRQLEYHAENVDDYEIYERYGNSAFFLLKKECNSDLDIKKMKYIASKSYEYNELIGMSWDPDYANFLNNGFLKIVRVYNPNLVMVQQRYKDNSTDCQKYFYALAAKFEISKDKTIIVKASADINDHDPSNDKYQNEIVKSANLFKTDIDSEDDIRNGKLEKTFVNLAGYVIENTGDCVNITYVESINKYCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF38</accession>
    <name>V7PF38_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF38"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01590">
        <property type="entry name" value="yir-bir-cir_Pla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="250" mass="28860" checksum="D058AF11E7A3B99E" modified="2014-02-19" version="1">MNIVTYIMTWISYKLNQKKQDGITTFNDFYSKHMQNVEEYKNNIYGVTGYQNYIDLINKKEKLMDIDISDMSKFYSLFKKSCNMFNNAGKQGVGKTHFEYTKEFVAEHQKLNNNIGTEDSSYSKIFSTLSSDYSVLQKSDVIGTSLNFPSLSTEKTAENVVASNYKETKIVFSSETVESSSKTKVSYSDIISPILSLLNKLIPIPLIFVAALILLGIAYKYSLFGFWKLDQKQYLRKQLKKKRKDWIINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF44</accession>
    <name>V7PF44_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-phosphate-mannose protein mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF44"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23279">
        <property type="entry name" value="beta-trefoil_MIR_SDF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25991" checksum="64AE76E43475CE7A" modified="2014-02-19" version="1">MIYNHHFIGIFFLVLFFFKVYNCLYVTDGSAIILENTGTKYKLFSTDMKWGTGSGNQIVTTITSNKNDEELLWIVNLYEEGKSMMGNKIQCDEIVTLKHVKSNGYLIGSQHYSILSNNFELSIDKDNSFGRFQVICENKKGGSYWMLGENVYLKSLNQNGYLSTSKKYEFNQYNCHNCPILYHLETCITKSSYQKNEYKWIAKSGVIISAFGEEKSNKYNDDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF48</accession>
    <name>V7PF48_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIH1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF48"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="40634" checksum="B92E0C61449DDB8D" modified="2014-02-19" version="1">MDLKSAGNVWDALNDLYKNDKQLYDKFMKKHLNEINDSKPIKPKYCFCICTNVEKVSIKTSINEYKEKVCDYFIYIYHTKKIKSPILSTDFIENVNNLNFDNIYISTSKVKGESSKDMYAEAVIHTNIYKNMNNINFKNKIITRILEIIYNSERAIRNDIVINTNSFHFIDLNYIPKTTHYLNTKYFDNDMLNEQPHTNIDETDIKFLNILNEKNKKNNNKEQEKEKDQILIHDSSNDILKDIHPIKTVKNTQINKVDKTKIPKEVKSYQYTIIDRFLHIIMTFNNISYTNLETLKDGNNIYVYVSNKSDECMALHFKENLSDNIKAYFNEALLKLTISIELLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF50</accession>
    <name>V7PF50_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF50"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026160">
        <property type="entry name" value="Ric3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723:SF3">
        <property type="entry name" value="PROTEIN RIC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723">
        <property type="entry name" value="RESISTANCE TO INHIBITORS OF CHOLINESTERASE PROTEIN 3 RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1263" mass="150766" checksum="BCAA65C2C9ADD0A2" modified="2014-02-19" version="1">MYVIHNNFNVNGIMKIIEKMFKNNMDDIEMEDNSEIQNLKIKEYNIDSNKYKLTYLSFKEYCLNEVENGEDCMDYMEKDVTEIGNKIDNKFYSKYFKEINLLKHNLNELANLLKGLNELNNEIFYFFENVIDSKNIINNSMTNKSKRALPLINHFEELVYNLKNADNSFSFHNMLMQFGDELNIIIKNALVEYVYLHKQAKEHMKQLEKYMEKNVKMLTKMHKKIVLSIFYIASDINKTNDKIDFLINKNLNEFKEWVINENNKCTDKLKKIKSNIDFNFENINEVFDNSKEKLKDDYISFIDISKYLSFQNPNKTILSIIHFLNNKYSDDVDIIFLYNEEYVEFNVNDITYENDMSKNNDKSETPQEYIKFETNFNFTDLDIIETSKYEEVLKSSNIDNNSNFKQINKNNFEQIINDMILNNEMLENGTWIKEKTFQNNNNNNNNISYNDIYNEIQKNTKYIENSINNVDNNFSFKPNIINFIQSIKNLFNNFIFNFDNYLCSFEKNFDSQDINIHECVDNTEECNNKHIPIEENKKLEKEADVQQENLIVESEKEIKAVLENEPNESEIKINNSSLELTDYQKNEHTEVLLSDLKMALKNKIMHELESAIKEIVENEVSDVLDDDFPDDDFSDELENYEKDYESNKINTIIDSPKYEGENNSNSTEHLQENQTELVHSGELDVDKNNIFSTDIVKKNVFDGENNEHSEKSDEYLEKNDEHSEKSDEHSEKKKNDEHSEKSDEHSEKSDEYLEKNDEHSEKNDEHLKENDEHSEKNDEHLEESDEYLEENDEYLEENDEYLEESDENNDMIEGQSNDEDIDSVNDEDIDNINDENETTEKNKLNFSILHSSNLKYLWRTPIIKKLYNMYIEHRKGYMHNKNDENVDIYEIDKNELESQNDDINSLNFKEELKNIKDNIFYAVPDIYYIYDILDIYQKNKKNASSNNFFYNAFYGNDYLMIKSKGVNIETFIYPYFETLNLQLNESNICSSGNYYSCMKDYISNNIDKEKLNKKTLFIYLGTFKDEVFKLPNSKLVDDLKKFHLQQFLNNETEYQFFNNFLVQKHKEESEFFRKLKFYTVYHSQRKDTLMYGIDFNFYVSYFSKGDIHHLPFSYYYDSIIYFKVILASSKYGYQEIVPIDDDIINLGLMLSLDNKNKNVHYLIKPEVIEDTQYDLFRNKKGIVKLYKITYENVKIIPSKNKYKMHVTRNMNVILQKEVTFNSNNNKRTLYYIDTFYDKMSEIMKNNMNLELFGKTFFLHLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PF54</accession>
    <name>V7PF54_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfhydryl oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PF54"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18844" checksum="43DF013F62526788" modified="2014-02-19" version="1">MGNQLSFNIFEKRDDTKKKLYGNKYSEDDNNKREKDFTLQHNLLTNKKNIIENNNIGGNHQVNSEMNIKEHNGGDESDIEKIKKENFYLFDESLNSNNVKHPCHSQWFLFWVFAAYLNENFLESEKEYVTSFYSNFPEQCIQGKGKNCFVEFSQIHPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGS2</accession>
    <name>V7PGS2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1370"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1407"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1422"/>
            <end position="1437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1725" mass="207338" checksum="872A51F3DE2D2541" modified="2014-02-19" version="1">MENSNIFSEKVIEFLKKKKIRENKLVSDKEKKEKKYNINNFKVNLTNELNKNSVHLILQNEKKDDNKYQVVEYAIQQNKQNNKTENIDEIIPKSYTNSSILKIKNIKLKINKYLDKCHDVSTDKLKKYYISVNKIIDEIKEETLTKTNLLQKDLEISNDLIDKYIQNSITIKWNNSKVDIKRFENKKDNYQIAIEYYENIFLFYLNKNFITNINNILNNTLTNKSNNKTSEIENESKIQSRYYYLCPESINLQIIKEINIHLTQRIEEISNNWILVENIFTKLNENINKFILFFEKKYEDSKIDVNKKIQELEKQLKETIYFTNNEINVLIDNENEKNNIFIELLNYFNDYILHIYKYIYNKYKECEHVFYNILYEHNYDDNCYVYLSISENYIKNLKNEKLLKNIINMFENNYVNIYNDRINKIKKDEYFDNFFILENSQDFFIPFNQCYENYINKYEQIEHLLISYKNVILNLFFDFTNFTNIIKNNTKKNEPVEKDKPYNTLSKFKKKKKQKKVPQNFIHFDNKKLKREIYGNYINNILNYYNAINLRDDYFLLTFFEFLENLKSCVIISYIEIQKNITHYNNYCKIETNKLTTNFDILYNKYKINVEKCMNCTDYIQLNELHKENLELAKNIRLFFCTVEENANSTNNKFVTQLKEKLMVLFLSILKKAKIISTDTQENIIIEKKNNSNKKKNYEHVRTYNDNTDLKVVKQEKENNKKIIKNTEKESTNVKQINISEDDNIVIKQLIGEEINYKYIFDFTSFFQTIYDNYKNNIKILLSSKEFKSKNNYSPYKKNEKNKTQEKKHRKKKTDNVQTNREKIKISIENLVRNMLNQFQKKKNEELAKIDQVAKIDKKTEEISFLNQEKNNEDENDKIPIDELNYDNIMYNIQILKNIFEHFLQTYYTNFKGILFEHMLKIKENVEQEEYTKYFEKIYKNNYIKIIEENEKAISQIAENLKCKFIKNKENFDHLINKLNNLINEYTSVIDNQNVEEPLMKSLNKINKLFLKIEKKSEKKSENKSENKSEKKNEKKNEKNYKCEYQNDYEHGEEDYDVLVKNFKNNYKLFQDKLQDMINELNKEIKKVQIYYDMVIKIKEKNIDIEEIKKCLQNSINFRQNIIKKKNDIQNLYNSNIYIFNNKIKSIQTNNATTTQVPKKTLTSNETITYLHTKEEIKNIILIFYFLLYHIKNSILITKITKQNNPQYGDNTKLSSLINTLPSQVKKTNIKSNTREGKNDNKDEIKVNTPQNKKIITHSICDNKKTDINTNEININTNEINIKTNEINIKTKFEQIDKHIYNKLQIFQKIKNIYELRISMNSILDNIFLSTNISKNINSLLFSKSQNILKSEIDYPITFSLQNNKSAKDISGMSEHFNDSGKKNDKESVSEKAIDKESVSEKENVSNKENVSNKENVSNKENVSDKENVSDKENVSEKKNEPNLKLIDIENDVNKYIENTLTRKKYSDLKFFLYTCTYIICIIIKTLTPYSNNFFKENTKEYNHILFIYYDISYLIYKNYILQNDEKIKNNNLKELQIQKDAMSSYIYFTDNMLYKIKLFNLFNFEKKIVENFIHTHFYTLSKIKINANKENPNWIKIQKEYMEDLFTLSIYLKVVSKKVAYFTFKEIYKHHIYLTSQRIDIMQQNFMLKFEEINEELEIKDNIPDTKLMRKTELYKLFNLYIIGIKHILSNHLYSLYENLYSNFIFFVYLLNMLPCNSGSHQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGS4</accession>
    <name>V7PGS4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_03788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGS4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB58629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="280" mass="33274" checksum="31C1D4801DB9ED19" modified="2014-02-19" version="1">MDGNRRFAKQMGLHTSIGHYLGSKNLIHIIELCIQLNIKILSVFAFSLLNYNRSPEEIHILFYLNLFFLINEEYFLKFVKQNKIRIRVIGNLSYINEAYREIIHNTEEKTKHHDNFTLNIFFSYTSRNEMNLCKINPNLYFDSYKDLLKKRNINYSCANSNDSDKTNIQINPKIKNTQISQVQCNCGKACSLDENQIKILNYHNKLLTADLPPPDILIRTSGEQRLSDFMLYQISEFTEIYFIDDYWPLFNFLKFTYVILHYTIFRTSKNFFSYSNPCQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGS6</accession>
    <name>V7PGS6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_04410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="917"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1284"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="918"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB57538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1587" mass="183886" checksum="F1ABCDDB6CAE2671" modified="2014-02-19" version="1">MKNNMNIPNNINNNMNNNYNNENYNNVNNNSRNLINNNLNIPAGLNNMANNMNDRSNNMKNFPNGVNGLNKNIGNINNINKMHNPIGKMHGHINNIPNNMGTMNSNLKHGVQNIINGMPTGINNMHSNLNNIPDNIKNMANAMKPMPNNINDIRVNANYSMNNMNTNVNPNNNVNIPNDMKHMIRVNNSDITSNVKFNTMMNNNNNSHFVSPDNSNRNMFYVNDMKNVDNNVINMHNKRNNNAKEKKNNIPQFREKEYLENVGHRDKYLLNKNETDKIYLQNKQLNNMNQGNIPNINNNNTRNNNTGGISRMINNNAQNTININSNNNINSVTNIGNNNDNNNNNNILQRNMKNLENGGMHNPLNINQMNAMNLNKTFNFSSNDPHNFNINSAADNKMSNKFKDSNYNNINKNINIPFNEESKYDPYNLGNNINRNNGNNGIVVEKNMNNAEHSFSKQHNNGMFDIKAHSGKDNFGGIKNMNDDKNIRYNSKLNEMNNANKVGKDIINLSASNIQKLNEKNQKANGNSNTNFMGNNLPKSMENADLYKLQMNYDKLNSNDPNNYINKMDNYNDFIKENNKGKYISGNKYNANANTKGDQSKNKTQKMENELINKKFNPINNNNNNENAPNHHMNENMIYDEMKKMNNTSFEKMVGNDMFMFNGNRSLEKGINQMVNMQGFRDIKNIHNINNYRMANDNDPRSNEKNNNMFHNQRPNFEGCNGTENLKGTGNELEEKKRKKKREKKSEMEKNEKNEKKGLNRDENLDDKKTINQLIEHNSFMHNLNENNESSEVGQNIKNNLFNDISKNYMQGQNIGNDEKELNIDSNLNENMKKENYAYIRKQNIFENYENMNNLKNAFLEGDQNMLNNANIFNKINFKFQKKKSDDSYENASMFPNDQNDEDKKLMVLSRLFGNVIGENGNNNNNNNDDDNNMQTQNENNMNNSGKLPNIRKMNSNALELELYKNMPLDTMLNKLNLDKNILNILKDKINNINRNINVNICSTSMETPEEPIKMENIDLLKLINLFDEFLNWSENNLYQIKLQLYNIAFCLLLELYILILANKFSMLIDFKNKYLKNFEAYHPVIKFLSNCVSLNQIFEISILRFKEKNAKHIAYMNKLGKASLMHYLSVYGSIPLYNLIMTKIKIIEIDDANKNFNFFHEFISMNFLYNGNLNVPVQWNLPSIYFIKDVSETQNDDSIKCTKEKEENVYIPNENSDAYYYYKYIIKMQAENRLKVTKNRMPSMLYYCLNNCTDMTCAEISSFDGSLVATAHSNNIIKLWNIKKSQMNKIKEKQKDMEIYNNENVDEINNYSNIQENKPDSIHLDDQDENGIAKLYGNMYNISSLCFGETNKILLSGNLNGDIYLYSTISNRNYVKYSGGHTPIWSIDTAFLGYFFCTSEDDGNLRIYSTNKTYPLVTYKYNCTSNICKYHYNNTIVASGYYDNYVHLYDIRVNSFIKRFKNNYPSNNGVTSLSFSKNGRLLSFGGGYTNNINIIDLVADKFIDVEPKQFINTKEYNLGDYYSNTKFEENHLGFYPLTNESEKLHMHKNIEEFEDKILSIDFSYDNNLLVSMSCDSHIDFYNCSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGU1</accession>
    <name>V7PGU1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 5">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_04266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 5"/>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="7">
        <location>
            <begin position="928"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="805"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="872"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="805"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB58210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1294" mass="153400" checksum="D8EDF6686B9AE421" modified="2014-02-19" version="1">MNLNENKSQNGFNNAIQENDDSMSLVSEGLDGSGNEDYRENEIEDYRNNRKEKYEGNNNANTHESLLKNNKDNIDSKLGFDIRNVLRHAYLPVCIEKMKEGEYVYKWNNNNIFQKKTLKFVYLDTNNYCIRWNSKKKKLKENKSLALYICDIIQILDGSESTFFKKKEEEKSLSIEIISIDRNLRITFLDIQRWKMWLFGLMYYHYKLVNKSSRERKKLKPFIYESNKLYDNYIISGLKDINVLTLSQLYIILRSLNIYINMKILYHYFSIYKNKGTINYYGFTKILEHIFSNNHISIHFNMYKNNDSNYIDKNQFINFLIDIQCEGKSEERIFKIHKKDNYPRLIQDKVEQNEIKKKEDNHAQNWNNNQVYTNQHIIKDKNEHNISENISNDNKISKNNSMIDEITNGYDLDYCEWRNLMKTLDISDNQNEHNLQCNANIELNSFMVSDHSKQYDKDYAMILNILRDKYGVYSTTNYNDKFYMNSHSKSEKKYKREIYTYEENNRKEQTNEISKEDKNKDDFYFIRTNIIYKSLNTIKKYNIPFVIINEGNHYLTQIGLVYFLLSKENSIMCPEYAKVYQNMNLPLCNYWINSSHNSYLGRKQIFSASSIEQYIYILIDGCRCVEFDCYYFNKNIVVYHGLYGYKLTSSILFCDTLIACKMFGFSTSPYPIILSLEIHCKDKHKNLIAKILIYILGNQLYIPKTKDEINNITPNNCRNKFLVKYKHFDNNYTSSFYSIFEGLKNVMYDELGYFSDIINEQEDIDVDEPKEYQIIEKKNEKYNKISIENQNMEPEDRVNNYIEQNNSKNTSYKNNQVQKTNKNSDQNNLCGNENVSQRDRHEVDSNYSSSSSSNCLYENNTIHKTQIDEKYRKNDNCSNNNSGFNNSSVPNNTNTSDAITNCGKNMSETAHMSKEEYKKKQDNEKYKNNILNKCSCLKGYVFRNFQENRTYNEICSISENKFIKLIKKNEDDVIKYNQKTLTRVYPSGTRLASTNFNPLIFWSAGIQFVALNYQYNGLSMLLNKGRFLENGGKHSGYILKPELLRFNKKHDYNVLSLNIQILSLHQINLLFSIKNKYQEKKLKKELFKMDMIQRIQTHKKISNKRKKFKYLQKLEREKKSPLLSDIQSDDSKKKKKISNETLLKKFKDNDNDVNYIHKKFANIEKEYEDMLTEYKSFLLCSTLSHSSSFNSCSSVTTTSNNTTDSNKKVSSKSKKKNFYQAFLELKKANNLFFYLYVTISIHGYNEQKCYFKTEIAKVNFYDINYCWSKPSNFQMKIVHPSLALIVFELKSYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGU8</accession>
    <name>V7PGU8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGU8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="38118" checksum="41C28B2A32C86463" modified="2014-02-19" version="1">MEKDKSAINNEKYKNLVDCYYLLLKKFKKKSAYVIDEFLIKENKNGDGSLILYEDINSDAFFFLILAMIDSNYDRINKINIMNMQNGNDIIKGLCFYIDNIKICDLLKKNIKNVRKANPIVERKNKLNLKKKTIDPEKKSDSIKKNPCNIKSLRIFNTNIDINAIILLSKILYDNNYSKLEHLAIDCINLENDSLKYMSLSLCNYNSLKSLSLQYCNLNNDAIKYIIDIVIYVNSSITTLNLSGNKFTEEGICSLFESFLLNNVLSNIDISYNMFNLSSPFIEMLSKIIINKTNISSISLIGNFLDNDNLSKINDAMTFNKSLSVLKLPNGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGV2</accession>
    <name>V7PGV2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGV2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33406" checksum="0616C72A152ECCD5" modified="2014-02-19" version="1">MIDSNYDRINKINIMNMQNGNDIIKGLCFYIDNIKICDLLKKNIKNVRKANPIVERKNKLNLKKKTIDPEKKSDSIKKNPCNIKSLRIFNTNIDINAIILLSKILYDNNYSKLEHLAIDCINLENDSLKYMSLSLCNYNSLKSLSLQYCNLNNDAIKYIIDIVIYVNSSITTLNLSGNKFTEEGICSLFESFLLNNVLSNIDISYNMFNLSSPFIEMLSKIIINKTNISSISLIGNFLDNDNLSKINDAMTFNKSLSVLKLPNGVDKAILKEITLKLVKRKRIKKKCKKKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGV6</accession>
    <name>V7PGV6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_04429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGV6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="101"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB57563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="340" mass="40478" checksum="1051D79FAD63A0C9" modified="2014-02-19" version="1">MIGNKEEAYECFNLATRYMKVGNYSHAKNLFLKSKRMFPEIDITEQIKTCEEKINKSEHIGNDNTTSSNTNNRTYKADQNNLHERHKSKDDGIEKILRTNNFYEILGIPKNSNDETIKSAYKKLAKIYHPDKNKEKGAEEAFKKISKAFQNLINKEKRYEYDNNLEMNSHYPTHRATHFYYSDDVFTPEDLFRSFFGINFATCNNRAFRTNINTENTHNNNNNSNSNSNNNNQRNVSLVQISIFLIMFVIFFLSSYFEQPRAVYSLQKTNYFDTVNYTSLNRIRFYTKRTFGYNYPKNSHPRFQVSFFPFIYLIMFICYVYTIYYITLVVFIFFSRLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGV7</accession>
    <name>V7PGV7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGV7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31715" checksum="BFC1E71408BC41BE" modified="2014-02-19" version="1">MNMQNGNDIIKGLCFYIDNIKICDLLKKNIKNVRKANPIVERKNKLNLKKKTIDPEKKSDSIKKNPCNIKSLRIFNTNIDINAIILLSKILYDNNYSKLEHLAIDCINLENDSLKYMSLSLCNYNSLKSLSLQYCNLNNDAIKYIIDIVIYVNSSITTLNLSGNKFTEEGICSLFESFLLNNVLSNIDISYNMFNLSSPFIEMLSKIIINKTNISSISLIGNFLDNDNLSKINDAMTFNKSLSVLKLPNGVDKAILKEITLKLVKRKRIKKKCKKKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGW6</accession>
    <name>V7PGW6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein axonemal light chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_03825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain LC1-type family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGW6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000049">
        <property type="entry name" value="Dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB58674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="197" mass="22840" checksum="A91B9123933374EB" modified="2014-02-19" version="1">MNRVVKEVTISQCIKNWEHKTGKKISEEENVSFICNIPLIEKLDQSINTLEKCKRLSLSTNRIEKFVPMSGLKNIEILSIGRNCIKKLQFLEDISGTLKQLWISYNNIDKLDNLQSLKNLQVLYLFHNKIKCLEEIDKLNTLPELIELGLKGNPIYEGRTNEYMKLVILKKLPQLKVVDNETITEKQRNDALTIEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGX0</accession>
    <name>V7PGX0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="801"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="871"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="801"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="871"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="772"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1065"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1462"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1826"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1325"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="772"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1462"/>
            <end position="1477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB58245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1944" mass="225618" checksum="21D287E676A0DE31" modified="2014-02-19" version="1">MEVATEGGSFEKLQFKKCEDKYILDQHLRTCFSYLLLYIIKECYYIYKIKCYIIQNALKIYNSQSKSSILNNYKTLSYLLYSQKWDNNIIYDIINNSNYFCNYFELFNGENYFTEDIHKTNKIKYLPNPYESVKNSINLKEQNKYEEIPPYIQFDNTTIRGVTIHHNLENEFSQILNGIKPFLSTNENPNNKKRKTKNKTIATININEKNQILRIKNLKNIQTTENSFINNKNQPNKMNAIIDTGNYFSKTFISSFQNDINKTDTDIFNESIYEYGQNSKYLQHIQREILNNNIVKDGISIFEYKTLHNIDHVNKFSRNCEYRDNSNLNNDAGQNNNGKNENGGDKEKEINNNDNSNNSEKDNSNNNQDKNNDQNQGGGEQNGEKEGDGKENDNNNDDNDDNNDDNNDENDDNNDDNDDNDDNDDGDNGEKAKEISEKEKYKFFYKKIKEIKSNIFVKRCKNVEKYFKKKIFNYINKNNIICNMNIDTIFIYLKNIYYLILNNKQLVFFFIYNTNDVMTAIINTEKCNEINYSEKKFFLYLLTNEKEIYKKIFDEINLKYDKNELILKLKKLKKKLNDLKHTEETNLFEESMKQLGLFKDIKKCVNSNNSNSQNNISNDDIYKLFNYTNKKFLKNYKGVSHKLSLKNLLPKLYNCKDLKETNNLICNVGKNVKSVTKSGGGVGCDGKKKKKNKKNKEANMKKNNMNNYMTNLNSHYNNFMNNNIDKSQINNSFNYFVNFQNNNGQSNNNVNNYSRFYNNMQYAQHMQHSVNFKDNNLNDKNGNKNNETDEKGDENEVKKKAIRGITSFTLFAREKRKELLNQKVFLGSSLTEQTSAVAKIWNNLSDEKKKEWAVKASKINEENFLLQKKKKKRKFTAFSIFAREKRKEYKEKNIDMGLTLAQQNSYVSKLWKQLSNEEKNRYKYLSNTVNAAVAKNNKNQVNYINGQKVSGFKGRIKALDNMMSQHFSNNNNLMYNDMSNFNNNNINNSSNSNNKMVYNPNQVMMGTENNSYNMNYMANMQNMQNMQNMQNIAQGDNNMNYFNYMENMNKNITMGYMNNDMNMIHDNGDDKNKKNSLKKNKKKKNENFNDPNQLMNNPNYMLKNANSFNQQNYNSLPYHNDGLNNTNNYYPLTFPNDNNDEMNNNNTINNNSELYRNIVINNNTQNLITENNQNVMINNMYDQNQISINANNIVNTTTQITNMKNNMTINSDVPMINNTKGDHNISINPIDNNELIQGHANVYITNGLNDNPGISNKINFPLHGHSEFSYNKYPNETNEIYEHDNVNIGGTSNGQTNMVMHNYQVINGNQKKGTKIDDILKKKMMKDEKKKLKEEKMMLKEFDKRRKQLLKAEKLMEKNKNKKMSNSDNNGIAAIDSNSGYYDPASVMNNNNNNNNNSNNNNNNNNMGMYMNMNNYDISNPLINNPMINNYNFYANPDKKNINPLNNNNINIVNNAPSSISTRNNTNNTNNNSGIISAPTDEGNNDDHLSNKGLINFKHVINGNGQNISNDDEFSNYTYGNKFMTDSGGVIRNNNSIPNDTNIQISDDIKKYDHVINNNIHDNTKLGNHISDHQHISNDQIQNPEINSSVINSNIPDGLNHPTYLNSNKEYYNNTNYFNNVISNDQVMFQHTNGTSNVVNNGVPIKYLIENGSNSNKIYGYNNNNNNNYLNNINPNERTANGISGGSNNNTGIIIKNDEYFNTIAREKENNNNNNNELKVDQTFNNTNYYQKNGTNKYTNRNNTNVIVGSVNNNNNNNKINNSISYDPDDNNHTYSNITNTSAHLHNSKQHNQSQYINLNETINNDMNMGINMEYNNGMNYININNNDNNSNNNNNNNNNKNNNKNNNTSYFYPHNRNNNVPNNNFLPKTNENNTTALNCMANGDNIMYFPDHVVSENNKIPGNLVYFDSDMNRISGRMEDIEINGHKRKQQFFNNASHFLERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGX3</accession>
    <name>V7PGX3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGX3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="29458" checksum="B876B274E60E2FBE" modified="2014-02-19" version="1">MNMQNGNDIIKGLCFYIDNIKICDLLKKNIKNVRKANPIVERKNKLNLKKKTIDPEKKSDSIKKNPCNIKSLRIFNTNIDINAIILLSKILYDNNYSKLEHLAIDCINLENDSLKYMSLSLCNYNSLKSLSLQYCNLNNDAIKYIIDIVIYVNSSITTLNLSGNKFTEEGICSLFESFLLNNVLSNIDISYNMFNLSSPFIEMLSKIIINKTVEKKKIMIFLGKCSLLAIYDYVYMHNNVELRKYNIKHIVINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PH61</accession>
    <name>V7PH61_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PH61"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="239" mass="28104" checksum="E03C7B4DC958C8CD" modified="2014-02-19" version="1">MNNRDFLLQSEAFSLDEIYGSDVNDEQNRLIIEFMKNMEKERSLLPSTVVAKDIKTDENKNNNNKPHSIYNIIDMYTENGELKETHFIKGYNIKWKNAVVQCLNNLRNYIHKKYNRRIINSSKYLTTNCPILECLQKNENLISIFLSKPLCIHLYIYDSLQALDMDVASNLQVIKRFCLNKIENTDLPITYENNKSNLLNFFTNFTCKSNEKNYTDSYNSPCAIFFIIYLLITEILSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PH73</accession>
    <name>V7PH73_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PH73"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="30302" checksum="DDDBBEB0F7464CDA" modified="2014-02-19" version="1">MEKDKSAINNEKYKNLVDCYYLLLKKFKKKSAYVIDEFLIKENKNGDGSLILYEDINSDAFFFLILAMIDSNYDRINKINIMNMQNGNDIIKGLCFYIDNIKICDLLKKNIKNVRKANPIVERKNKLNLKKKTIDPEKKSDSIKKNPCNIKSLRIFNTNIDINAIILLSKILYDNNYSKLEHLAIDCINLENDSLKYMSLSLCNYNSLKSLSLQYCNLNNDAIKYIIDIVIYVNSSITTLNLSGNKFTEEGICSVIIIICYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>V7PH91</accession>
    <name>V7PH91_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_03992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000019">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="8">
        <location>
            <begin position="282"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="7">
        <location>
            <begin position="678"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1350"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1363"/>
            <end position="1375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB58380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1516" mass="176521" checksum="6E3FC9FFACE9DF66" modified="2014-02-19" version="1">MMENNSSSSDSEGRCEQNEENNENSDKKRKIEIENNEPNKIVKTINSNNNFKDNIKQEEDVLTMNKNLSSLNKNIKNDNILKDLDGLDIRIEIDEEHKLDAVNLKNENLDKENEDSGDEKNNVNDSILKNKYEEIIINEDTGYVNIYVFDICKHKNSIILFGRTLTKLKRYKSISIYIEDMDRCYYFLLNKNKKYVKDGIEITYGHEKYKNFIMLDFVSEFKKIREYHNIKMAKYKIVFRKNLNLSSNNEELYAKVLYSYNYDNISEQFSKGDTYSSFYCCNDDIVENFIIKKNMKMPCWVKIKDLKNNFSNNIAYCYFDCTVASKKNIFTLDKFMEKKNTDLINGSNHNPTTNSTNSGIIHDESLKKIDNNNLNNFIDIDLNKLVIRVVSVLNEENNHEIFSICSLVDADGMKYINFFGICVKSNKKGSTPNISNNINDNKNEIYSYNRNNCKIFPNEKLLLQAFLNKIRTIDVDIYIGYNILNFDLEFLIHRCHVNNIDPGVLSRKKKLKKSDKMKVNKFSGTNSTGSIYNIVQNIKGRLILDIYALSKDTIKLTSYSMDEIIDGVRTKFQEKVKQQTGSNSVINGNNNSNNHTNKNKSRENIQNVFKDFIVNDINLINCNNIHLFDSEQILENHLNTYINSQIFSIYEIYNVCNVLQLVEKSRDLTKLSGYIWARSLLSYTSECVEYFLLHEYHKKKYITPLVAKKKTKIENDSNKSKNTAKYLGGLVLEPLCGYYDTYVLYLDFNSLYPSIIIEYNICFSTFNMKNYLALSGSTSEEIQEETGKRNIIDYNDSDVNNLDKDDQVGDISNIDYFDKTKPGILPSILKQLVEKRAFIKKLIASEKNKEKKELLLVQSLSIKLISNSIYGCLGNTHNRFYAKYIASYITQKGRNLLQHTKFKVEKEFNLKVVYGDTDSIMIDTGIKSSDVNNYKESLKLAHTIKNNINKNYKKLELDLECIFSKLLLLKKKKYACAKVIDPNLGKYEYEMKGINFIKRDFCKISKLIGNEMLRIIFSNKEYKPSQPNSSNTSLSHTDDLSIQNDLSEQIHEYLRSVYQRIQNDEFDLEHYVITKKLTKNVNEYQEKNSLGHVLVAERMIKDGYNVCVNKEIQYCVCRNEDALKFYNKGNEKLNSSLCCFSISEIKKYNLKIDKDYYIRNQILLPINRLCQYIEGTNIEKISSCFNIYNVKEIKSDEQIDESYLETNVLSLLSETEERFKNINLKGFLNCDNCHHDVKPVIFIKYFRCNKCFSLLPIDKIRNYIFSFINHLCSTFYKQMYICNSCLLKTRRIFLKESNNCPNLNCDNPKNSLKPILSKKYIYSILEYFLYLLKGNLLIIPTKLHQKGDVDAANEAGNDENKAENGANKAENGSNKGENENKTNTQINEEPEEYATDINVSVCIGDGYKIHILNNNQLIKNNKKNVFKIESYDNICKNKELNLNITKGLQMKFPNISNFITYLNLKNNTFCINYNEERNTIRESIQNIIQNDIYSQIFFDNIFSVFHLYVASKISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PH92</accession>
    <name>V7PH92_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PH92"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="59" mass="7031" checksum="88E6320E1236615E" modified="2014-02-19" version="1">MGFTAGKCCKYIRKYFTNGQRKNILPYFMYCKNKPFIMNPKFIQKYSLEDVPPKIINSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PH95</accession>
    <name>V7PH95_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PH95"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="392" mass="46092" checksum="AB88AF56E9C6662E" modified="2014-02-19" version="1">MLGYEENSNQVDQNIPNHEEEGYTETMQDEGENKKEKDFERIDDTQNDSIEEMERILEENAKAKIEKKKKHKKKTEKKSSKNRLDTKDIFESDNEINKSPFFSDISSYADYCTSDDGNKKKNKNDKITLPVNKKETKSNDENFNMINGKTKRDYPNYKNGVKENQNEYNYSEKEDNHSDNSEQNTTSAPDTVPNDWFFSKIKEIIEPNINQETLNQLITNNYNSFSEANTGIYDLIDKIIHTNNNTYDNSQNSMSIINKQSYHGNIYDHYNSMDVSPNDNYNFINYSIYCINKELSANVETEAINMMKIYAHTFNKYKKDINYKDDLYKDLLNEAEEQSTIILKNNRKKRIYKIDFFNLANMNSENYNNIVESQNVQTPKIKLEDIFKISVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIW1</accession>
    <name>V7PIW1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fam-a protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIW1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764105" description="Fam-a protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33886" checksum="15E17FEF92EB3C0E" modified="2014-02-19" version="1">MNKGYIMVVLFILSLFIYMNNNALAAEHSPKKTKTRFLSKKKISNYIRNLISRTPIYTLFANPDNNNNNNNKQPIPFVCTKRSEIKKAENVMEEAIERLKEHAIHSNDYNLHYRYANEIDIYRKRHKYVIVDKIDIEINNTDKYEEIIDTLSNFNNNLYSFVTVKGKVAREYNPNLVMIQQRFSDIPDQHFRGYLYAIATKQQVSEDTTIIALTSANINDYNHVDQNLFKNLIVESANSFETEVDSENYIRKRYLKKAFVHLSGYIIKKKSKSIHITSINAVSNIKILIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIW4</accession>
    <name>V7PIW4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_02891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the inner dynein arm light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIW4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF0">
        <property type="entry name" value="AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="181"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB59379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="29867" checksum="F257C4E72A8A598C" modified="2014-02-19" version="1">MLKIMKEYKDYFEKEFIKNCNLENNINLMENLEIKEDNDYNEDVFIKNQKSFHIYDFFNLSLLFPIKILNQNGKSIIQLISEDNTPNDLNMIQTILKNIEQTEMDKLRFFHIENIIYELIDELIRQIAVDCPKRGFSLIVINNEIKKNIDYYKRLIEIIEHNNNMNTEKFNEMQRKYSIMIEQLSVEENNLKEKLADIQNELELLRNTNKKKAQENRNKMEIQYDLLKHNESLLEKIKEIYDKQGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIW5</accession>
    <name>V7PIW5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIW5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="835"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="893" mass="103368" checksum="8789063C20806A23" modified="2014-02-19" version="1">MIQYITKILIYSIVIYVYLNYNKKSFSICISRKNINNNTKFLAHARILASLDTEPLLSPNNCNKIKNYNKIIKKTNQNGQTIVQRIAKTPNNGYNNKYIKEKMTKEGVVKYVHIQPDLVKSNIKDVLEIKLHEYQDKKYVLKEPKISTRHKNSKPVIDSIKKQSQISLSNRYTKDNKFVLYNDYNLTKLISQHLLNLKNNNVLKNESIEEIKSYIIKNKNKLNEYVDLEKLDILKVILNNTQFNKVSPDEINIMLYYALSEHPRPHRNLPYYHDIISKDRNKLNQANIRKETTLKQNKVGKNKILLQPNTRRQKLPHGILVDTNNITNKILVDRTNLPHNILVNKNNLMNTNLVEKKNSTQKNAVRKNINDNNYTTIKDNLENKKELSSNYDLIKKQNIAKIKDESNKVHNPIEKYANTENQISHEYNNSISTGNKQYELKAVNKVRDVYGNIANDASTKQEKMIKIYMEDEKGEQQESIKKERMIKIYMEDEKGKQQRSTTKERVARINMEDKKGKQQESTTKERVTRINMEDKNGMEQKRKKKEIVIEIFMEDKKGEQQESKKKEKVTEIYMEDKNGKEQKSKKKEKVIEIFMENKKKHLFQSNIIDKKDIIMPQRENVKVLDLSPINKKKTNNNKNSDENDFIDLFDNDDEESLLTQVKDNNKIDVSIVDEIYAETERLLFEQIIGKKKVKGKYYKVKKYLKIFGLYVLPIIAATVSISLLGLQISTVMATDIFSGSLITAGKTTIVEGGQCLANAATDVMEGLATEVFPAISFSDFSFSGLFDSFITTLENTAIVGMKTVSNTTSCVSDSMIPKTISAATTYGVSVAFSQILYPMGIAINIAIIIYIITKIIVKLDDMGKFNKLHKYRKKVINKLKKKINTKKKRKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIY2</accession>
    <name>V7PIY2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1352"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1823"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1976"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="525"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1360"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1460"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1635"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1831"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1977"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1987"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2001"/>
            <end position="2016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2043" mass="244004" checksum="48D8899336D7F4EB" modified="2014-02-19" version="1">MNNYELYKNNTNSGDYLRNMKGLNLKNLFNRNGDDNNKKKDEETKETNYNFPYSNRNYKRNDDNNQDNVMKNNIRYNSTNVDIPKHNNTNKIDLNMLYNNNVDKLNSNLSAYNDTNKLIELQEKYKNKYRYEKDIPNHTNDTRGKSNNNQIKDNNIYFNNAILYNNNANNNDINNIKTDYNNYNINMNINDGNEINSKNNLPSNKSNQNNYISEKGDMTEKELDHYSNFNFNNDNRNKGSNQNDIINKKYKKLESLMNINKNNDDEKRKINFNVNDIKNNYFDNFYKNKNTENNEYKTYKPRRSNSSNVHTRKHDTGKISNYLNYADDMQAKINYYNEGKNGNMRAYEKYIKMKNENIHMNNNTHNLTMNDLNGNANGTIEMGNNSEIKNVNNNKTNDNNLNNMNNNYNENTYQNRNESNSKVEHDLGKLRNFDLNDIRKKHLNLFNNKMENESTYTNKMDHIMNDKNENYNFSFINEKNITKNLTNNDDDALNFDKNFRKKMDVKSIVCVCQASKQMARLQLHIEESRQMLETEKMLLKKKKENFEKKVGMLADKEKEIDKIHSQIKEKELSINKKNNEIDEKEKYVNSIKSKYDNAQKELLDKMNECILIENKCKSKLYEYDEKFGQFNKKIKEIEEREKEIEQEKKNIEKKENMLNENRREIDEEKLMNMKEKNELEMLKKELESLEKEKKKIIDCEYNNLQNKEEELRRNERNNLIKENELKNRIDKYNELIDELNKNKKEIENDKMKMLNDIQDERIKLLNETNNIKKENEKEINYMKEEIKKERISMINDVEKMKRLMLEDIENTKNIMLEDMEKENTKIKEEIENDKRMMIKNIEDEKEKYKTYLEEKFNENLEKEKSELQKKYDDENNRLQAEINNEKKKINKERDNLEKQKKVYEDEFRNKCEKYEEDIRKKYNMLEQEENNMKYRIMKEQEELENYKKNVYLDIEEEKDKLYVQQEKINLEKENLLVEKEQIDIELKNFKNFKEKEENDIKIRIINLSQQKEDLNKEKENIEKEKDKLEKIKYDLDAREEGLNNDKIQMEKSRKLFDEQLEKIKKNKEELLNYDRELKTKEMDLIEKGTEIKNKENELNKKKEKLDSLDNELKSYSSKLQDREKKLKEKKTELQKVKDQLVDYKNSLKEKEIQFQMIEKREKELLDEQTVIQIDRNSLEAEKKQFLLIKEKHEKDTEYIQEQLKLLHEQLKNKDKSLKEKENEINLLNKLQDCRSKNGKGAIISLKNYDNRKLNMNLSRISVSKNRVKAKAIGKNKFDIIRRTRRKSINYNYNNLEINNSIQYIDSVINDNFKNKPFLKNKNNNLELSNENFMQEQGNNNMNFKYPNDTYDNSMVDKNNRNISNNSMKNITDYGNNVENNDEPERENRNQNISNENDYYENKNNDNKRNKKKYPPKPRANLEKDSYNVNNGNKSERNDNFNDLYNDNTTNYKKKEKYDNDNNYGDHMNYNNNNDNHNNTKNGNVYENNNNNGGYNNSYNINNMNTNIKMGKSDLNDTIKSKNGLRLNFQENKDQENNNMLGSLNVNNLIESDIIDTKSNYGYHPDNHNEKYGENESNRNIMCINKNINFIDNDVNNINNNISNINSKLYKMNSNVYEENDSFVGEHNNKNRNKHSGQNNNENGMSNKNPNEKPSLNRLDSLVNQNMQSVNQISNLMQSSKKTNNNTMNKLNSNIKNYNSLKDTKRNNNDNYYDDNNESPKKEDNFNEFLEELNDGKSYNSNFIEKGDDDFYYNMEKSLNDKSMNETYDHKNRNNYNTSNKNMDRKVHTLKNNTNSTNFVTTNINTNHNNDNNTKINVHVNRNNGETRKDNINLSLMPGNNNKIGMDNNGYNSDSNIMRNQNYLTNENYNSRRMNSHAIEQDNYNKQRGHKNNNENDYTNYRKYGMENKKDELLGNNFNRAQIVRNHDNENKNVNIHKHNNSNDNNKMNTWNQNGNKNTNMVGIKGFMRELQNEKDSYNSGANATESNNNRNNVQNHKNYNTKYTNSANPSDSDAQANSNKIIEQLDKTLMNKSIVMNKNKKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIY4</accession>
    <name>V7PIY4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIY4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43336:SF3">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43336">
        <property type="entry name" value="OXYGEN SENSOR HISTIDINE KINASE RESPONSE REGULATOR DEVS/DOSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="535"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="735" mass="87466" checksum="B1EBD5C4EB1059FC" modified="2014-02-19" version="1">MMPDFKDICTKEIFPSKKIKRFFLKCRSKEKVLYSFTSENESMHGEKCRRSYKNILKQKIKNIHFEILTRRFHKCLSFLYLILIIFSKDILYIFFDKGQNILMDTITIVLIILNIVETIFHLSINTSYIYYFMFFDVLSLIMIFGDLSICENYVFNYLCSSFKSFYHVEDINNEEIFYLIQLFKALKITKMYRLVIKIIKDHTKDKYKHRNEWNFEKMESMKNKTCLKDNLKFTNKMHLTLIKRFFVSLIFVMLSYILIELVTFSKGNKSSMSYFIYNIDRTNFDDHYETEFLKALYFYSNIQRTKNDEEYLISFKSKVKLQNFVNKKEINIGKEKHILWDFTKSPYTEMMKLLDMKIPNAQNEEEITMDSTIKNSSQLRQYEMRVYKSKDFIFYINIKKKIIQKIKNIVILKLFIILFSFFILFYFSIELNILLFPIESILKKLKLMKSNPTLALEMQEELLNHELDNILRTKQLKKECIKGNYEILKMEENLMKLGTLMLLGFGEAGAKIISKNINDQERINLLINGEIVYSVFSFCDIRNFTEITEALKEKIMIFINLVAEIIHECCDFYDGSINKNIGDAFLLVWKYKKNYCLNKNFSNQEYTKTGVTSYEYYSEKKKINRICDLAFLSTIKTLIKLKQSEKIRTFLKSEKIDELVNNNIIELSFGLHFGWAIEGAIGSRYKIDLSYLSENVNIASRLQDISKIYKSNIIISGDFYDNMSENFKVSCIVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIY9</accession>
    <name>V7PIY9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIY9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="686" mass="82734" checksum="CE67C1A09ECC3F16" modified="2014-02-19" version="1">MDDDRIKDIYSILKTKNKKEWGELMQQLTKDQKRKLVYYIKKKNKKSLNKIKNIKIDKNVDKNKCKPSRYYGHVLIDYSNVKYDLNLKNYIARILRIYKLEDNFNFIKGLHLYMNILCYVIFKKFSYEYKNDNKNKDLLVFLKKIFPFEFQNFQDVYNKRWSNDFTSPENIIKQQDNVEIVKEVYNVDDNKLESDGINRKTNNTLNISDKGKDENTLNHENKYANTSNIKNIANSSSICLNLYNNNNVLNHKEKNGMNIRCMSNNMENVLIKTEKIDDIDNNVNHQSDDDNCYDSTEHNMSIGENNKEYNLEELKKSVKKEFIYDDYIFKNKDIQKIIKNLFDEKRFDYRLRFRSILSQTLNNEEYKKYCDLREKLFKYKKKKFMKWISQFTKINLLDLYAVNFFIFLFLDRLYLIIETYIRLNYCGKEYPHESSDNFLEDINEFQTFNNILNIFGDANPTEQENTLRNGFNNNAKNEQHIQKFKETYNNIIKEKFSNFFYSIELIYNVDVYNFKIKNKIKFEQLINTDISTYINETNVYDIINYDKNVNSDPWKALANFALLHNRNLKLEKFDCFSLFLIVRFKFYLEEFKENANIDYIYKTVKEEFDKVQNYLESQNGLNDVSKDIENKLSINETNEENQNDENEHDENSPNDFEINHLVNLYLDLQKELKKVHFLLLKENIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ74</accession>
    <name>V7PJ74_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJ74"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="819"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB58842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1174" mass="139603" checksum="A8EF52E63D1F0F07" modified="2014-02-19" version="1">MANQINGIFSKLADMTIGLFRFQMDNINEEIDENMSPLEKAMLYGNSNLKCRKILFIKDIIKLLNNIDYTDFQRDIYPLIVKLSDESSEIKYEICNKIGDLCAYILQNNNDGCSDVISLLFPIVEKFIINYENNKNILRYILKSLLILSTHVNIKTRKKQIFPFLIYLICNDAYKQIGFILLIKMCYIFDRDNIVIYKVLIPFIEKHCISNNIECKILISSYFFNICKMLDESNFIKNQIFIFNKLCNDEYDTIKIINIFNCTHLSSIYSKNLFFNFFLPIFNNFLKNNNLYVFYYSLINLLLFLCIFEDINIIHPFYIRKIIFFFNNLFSSHLFTLNYLNEMAKKKTNYIFLDNTDGVYDDSNSAKIWNKDEKRDDTPSYPLNETDMVTDFQNSKSEKNNEHTIQNTISNELKYYDNYLNEDMCKEKQNNLVEIIEKDPTRQICNDEQNLTTGCNIISPINGKGLWVEDNKNPHKNSPMQELPQNKSDKNINNESDERDKLGIGNISCEIESTEESKNCNFSSESEILNKRKMEKVLFSSEISELECSSVQSLSNEIIYDENVCIFINNKLINDLIIKNHHFCSNISQFFKTHGNDYYKNGNCDKYFGRKIINLMEKNSDDLILENKINGETIESEEFEKDEENYFINLNEKDIKYIDNIFNHDDNIDILQIKGCYYSELEIIKNDIIYGKMLLRQKRNMYKINNNNKCDSSDNITYDIDYEDIYAIEGVDTDSLKKLFLFDTPNNVIVSYNINAVYIITLHIPGLILILKEYFFRFFSHVFFFICTYPYYFVRKTIASLFYDILSNLMESPFFKINTDKLYEDRINMKKQKKNLKKNKKIEETAKKKLKEECSDDIKKKENNYDGEDSTEQSNLYTYKENNIKHQDINHIYKKEPPEIVQTFNNDYATYNNMKRIQNNSFLTSDKSCENTEDFINSCIMEKHEDVLEKEENKLCDDTLDMIYSNNSNTNGSHYSLDQDDTKNITTDTIDQIKEDKNDIQLKRVKKNAQGYRKKWSYDKMIKKVQNKINNNLYANDFFINEENENFFFYINFLGKYEMIYIKYIQKFKKYYSDNSPLHFFHFFIYYFLNDSNVLVKKAILKNYDKIIEFFPNNIQKIFIKYLSDVVNFKTLNYSLRKKVSKIVFKILSKINDAKIVRNCLFPIFMRYVFFFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ79</accession>
    <name>V7PJ79_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJ79"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="6">
        <location>
            <begin position="903"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="709"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB59060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1099" mass="126596" checksum="15D8945F6D0FA284" modified="2014-02-19" version="1">MWGKIVSSVSNALDFNQATLSGCIDIICIESEIESEIKNDKKINLIYKSTPFHVRFGKTKLLRSKEKIVNILVNGKTTNLHMKLGSAGEAYFVEKTYDDVEEDLETSPLSSPRYQYDDIFLENNIDSCSIYESSVNNFKSDKEEYEFYANEDENKLLLNNSQNKNTDISDKHNPYDQLPKNKSKSILERKVNSDNELIPRTCTRNRRSSKASYKNDNIKSHKKKSETKIDLKHSDKLSIKERHTTSQENTEKKKKSIISNNDEQDTNEDGDILYNLKTYQTIKKKTEKKTEKNEKKGEKTEKNEKKGEKTEKKGEKSDLKQSPNEYDDKNNNSEWSWSWGRLPHLKIPNQASDNGSIILSSSKKKKKNRSVAPNNKFNTDNNKNKELKNEHLLSIPNDLNVRKRNFSECYIKKSNDHNIDIKKYSLAYINKEKNINFIAKDSKSKNIINDAFAAASKNNNMEKNMEKNSIIHNNPPNNLEPQRTSQSKSTRPLSPNYNTKRSGEKKESNLNLHPTGPPTVPPTDSTKNMFESKVIKKKEEKKQSNDNGPISDDYIDEEENKSNFENNYYDHSIDDTQEHVFDDDIQNRIECSLCGHLLLNQNIDNEHNEYNIEIYNKNIFEANIVTYDQIDRNSNLWYHPSLVFRFDKKDPYYPSRVALPLLASWIVFNQPLSIVAVEKLLNSSLNLIEMKDKSWRNWFGVSNVENNNQIKSKNSKNEKQNSTLTHKKNDKKKNIPNSENNTNNIPLEKDTPHVTSASQSNREHKGNNNVKNGGQNSGQNSVKNSGEQNSVLDIVPNSHNAINLRNSSISHETNFFNFNKSNIKRSVQESLYSKNDDSKRSIRHKDDKIKIRYRKSLRPTSEQLQSLNLKEGANTITFLVTSSLQGTKSINGTIYLWKKNAKIVISDVDGTITRSNVLGHIMPIVGKDWSHDGVSQLFNKINNNGYHILYLTARAIGQADSTREYLFRFKRNDNKLPDGPLILSPDRLFPSFKREVIDKKPYIFKIAALRDIRNLFPLNHNPFYAAFGNTESDHRAYISVGVPEAKVFIIDNHGIVHHVNSTYAKTYETMSEITEYMFPSIKCDTKREDDDQVRMENVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ86</accession>
    <name>V7PJ86_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJ86"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="100" mass="11984" checksum="605E91CE69826CE0" modified="2014-02-19" version="1">MVKHKDYKKSDLIQILSSSVSKERNKAVKLLKRFEPLPRKHLDDKFDARNVVVHKYSAIKAYMCWRCDKVKQTNVKVHWETIEGKYTITHTFNICIRMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ87</accession>
    <name>V7PJ87_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_03992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000019">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="8">
        <location>
            <begin position="404"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="7">
        <location>
            <begin position="800"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1472"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1485"/>
            <end position="1497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB58378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1638" mass="190821" checksum="5C13AC2DF04D6BE5" modified="2014-02-19" version="1">MSNVFDKLRKQRSKECKATDFYEVKNKNDDIYEVVDEDGYIENKNSLKSFIVGDDKNYDSSDDVILETVDYSMITKKNAEKESKPKRNTQIDDFIREKKIQKIFSSGKLTKDDISKTRNIEKMMENNSSSSDSEGRCEQNEENNENSDKKRKIEIENNEPNKIVKTINSNNNFKDNIKQEEDVLTMNKNLSSLNKNIKNDNILKDLDGLDIRIEIDEEHKLDAVNLKNENLDKENEDSGDEKNNVNDSILKNKYEEIIINEDTGYVNIYVFDICKHKNSIILFGRTLTKLKRYKSISIYIEDMDRCYYFLLNKNKKYVKDGIEITYGHEKYKNFIMLDFVSEFKKIREYHNIKMAKYKIVFRKNLNLSSNNEELYAKVLYSYNYDNISEQFSKGDTYSSFYCCNDDIVENFIIKKNMKMPCWVKIKDLKNNFSNNIAYCYFDCTVASKKNIFTLDKFMEKKNTDLINGSNHNPTTNSTNSGIIHDESLKKIDNNNLNNFIDIDLNKLVIRVVSVLNEENNHEIFSICSLVDADGMKYINFFGICVKSNKKGSTPNISNNINDNKNEIYSYNRNNCKIFPNEKLLLQAFLNKIRTIDVDIYIGYNILNFDLEFLIHRCHVNNIDPGVLSRKKKLKKSDKMKVNKFSGTNSTGSIYNIVQNIKGRLILDIYALSKDTIKLTSYSMDEIIDGVRTKFQEKVKQQTGSNSVINGNNNSNNHTNKNKSRENIQNVFKDFIVNDINLINCNNIHLFDSEQILENHLNTYINSQIFSIYEIYNVCNVLQLVEKSRDLTKLSGYIWARSLLSYTSECVEYFLLHEYHKKKYITPLVAKKKTKIENDSNKSKNTAKYLGGLVLEPLCGYYDTYVLYLDFNSLYPSIIIEYNICFSTFNMKNYLALSGSTSEEIQEETGKRNIIDYNDSDVNNLDKDDQVGDISNIDYFDKTKPGILPSILKQLVEKRAFIKKLIASEKNKEKKELLLVQSLSIKLISNSIYGCLGNTHNRFYAKYIASYITQKGRNLLQHTKFKVEKEFNLKVVYGDTDSIMIDTGIKSSDVNNYKESLKLAHTIKNNINKNYKKLELDLECIFSKLLLLKKKKYACAKVIDPNLGKYEYEMKGINFIKRDFCKISKLIGNEMLRIIFSNKEYKPSQPNSSNTSLSHTDDLSIQNDLSEQIHEYLRSVYQRIQNDEFDLEHYVITKKLTKNVNEYQEKNSLGHVLVAERMIKDGYNVCVNKEIQYCVCRNEDALKFYNKGNEKLNSSLCCFSISEIKKYNLKIDKDYYIRNQILLPINRLCQYIEGTNIEKISSCFNIYNVKEIKSDEQIDESYLETNVLSLLSETEERFKNINLKGFLNCDNCHHDVKPVIFIKYFRCNKCFSLLPIDKIRNYIFSFINHLCSTFYKQMYICNSCLLKTRRIFLKESNNCPNLNCDNPKNSLKPILSKKYIYSILEYFLYLLKGNLLIIPTKLHQKGDVDAANEAGNDENKAENGANKAENGSNKGENENKTNTQINEEPEEYATDINVSVCIGDGYKIHILNNNQLIKNNKKNVFKIESYDNICKNKELNLNITKGLQMKFPNISNFITYLNLKNNTFCINYNEERNTIRESIQNIIQNDIYSQIFFDNIFSVFHLYVASKISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ95</accession>
    <name>V7PJ95_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJ95"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="514"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="814"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB58388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="907" mass="107532" checksum="681A7803103CE083" modified="2014-02-19" version="1">METIEKKQYNSSNENDNTYQDNTTDDEERKRKRLIEKKRKIQYEKERGKYREKNKEREEEEEHTKYNEKKRHREREKRMKYEEMKRKKREEDTNSDSSSSSDDRSSSNESDIKDKKEYIEKMEKLRRERRRDRSRDRIRDRSRNRSRDRSRDRSRDRSRDRGRDKYKLRGTYTNVEVRIKSSKHRNISSDDEKIKENKKHKRRERDDNKNKDSNSSDDSEDEKSREMNEKKSREMNEKKKTIEKREEDEDEDENESENKNENKNKNENKNKNENKNKNENKNKSESDDSNEESDQSSVRSSSESGRERKKMRSHSRSSYRERRRRKHRNSDKRSRRDRHRSSERRRRKRRRDRERDRERDRKYKRRERNYKFDSPPDSESDNNNNNSDNDKKKKKKSNFSSENTNNNILENNNLLLNATNTILSNAGKIIPNVNLNNPSSLLNIFASNSSQSGDNLIINPGNILLEEKKNITLNKNPLNLLLNTQSLQQLYKTAFGIPELGLSTIDANAEKTARELYVGNIPQNIDIQEIVKFLNTCLLILYNKENENENICLKACIRGDTRYAFVEFRSLQDTSNCMLLNGIYFYTNNLRIGRPKTFPIEYTKLIPPATIPTIDTYYLSQGLVGIKAFAIFHQNKDENKNEYHHLPVDMIKLQKLCVSNISKNNETNKIKELLEAFGDIQTFEFFEGEENSDTYICLVEYNNIENAIQAHKILNQNTSYKIQFEYEILNDPTINQLVKKKYMQNKNSILSQQIPTKVIVLSKIATFDELSNPEDYKEISEDIKIECEKYGSVIEVVLPIVSLDTYNYLTKKSEQEENTMDEMEERGKNKLDGGEPSPCKVSETDEQSNSDRVEKAEANNQDKQLDNVEEHPYYDLSSIGCAFIYFETIEGATKTRKELSVRELCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLA5</accession>
    <name>V7PLA5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">YYC_03022</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLA5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="502"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETB59577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="992" mass="116786" checksum="4081A10E74D9D8D6" modified="2014-02-19" version="1">MENKTKCLQHKNDVTHVKSPQITTNKNKQNNNDRLIHKNGQENMPNMGGIYDKKKSKKIQPKKYGNNLSNIKNKTSEDLYNHNNKSKYDFINYLNNIKSNFSIINYFKMLVNVSIYNYIPFNFRNISNDAYVCGNSFILKDPNSLKLFLILCKSKILFTYRSNFLIKISDSKTLVSSSNSDNANFCVSTNMKNSNNFLEINKVVESIKSSTSFDDAPTFRDTNIIHSVSKNFDNEKINILTSANNNDKHINPSTDNDIIIRNDLNISSINKCYHYNNINNDKEENKKGFKKNRGTKIKGKYYKNRVINFTDIPEHFLNKIYYDKKKYLYINCENISSFSPKYIFNKKKHVHMNKDNYSCNKNDFSDNLIENKTSADIHLNNVNDSQETILYIKDNFENEKSNFSSLSHNSVENDNSVDTEQFITRSNDKLISSENNNLNNLENNDLKMYKDTSEEFISKVNKPINNANIMDYYNDSNSDGQKKHEKLFKNELYTIKKKLSTNNTINSKIKNKYRHFFKLKKKRKKKKTDDTISIYMSDKGWGCMIRVVQMVLVNIFVKYTISEDFMFFHNLNDYIFYKNSLNNLNTEKLLHKKSEEKITKYHTEKIKLNKLKEDKTYEIYCLKKVSKSNISHENDNCSILSKNSNHTLNGNIKTMHQQDQHNYKYSDISLLGLKNRILSDNNNSASSNNTNISHYFKCYKTYRDFLMNSENNIQDMNKNNYLIFPILSKFRDTENAKYSIQNIIYEAMKYKKIHKESIEKFVYEWFGPTNSAIIISNLINKKKVCFLRKKRKNTIIDKHVDKQNIIDRYKNNTKCIFVKKKYRNAFFSIAFETGVIYNNRVLKFFQIKQKVFVIIWVCLKLGIDSKSILKYKQSILSCFRLKQFQGISGGNTYTSAYYFYSANDNGLFYIDPHIKCQKAFTDLNTNISSEFFMHRIKLLPWEHLNSSMSLVYVVNSKDDYFDLIHNLKLIDPNIFEVYEEEPKYTFKGGNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLA6</accession>
    <name>V7PLA6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204:SF0">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1340" mass="155082" checksum="26364DFEDC738376" modified="2014-02-19" version="1">MEEENIKIKVKSIDNQECEFCVKKNTTAEELKNMISEKKNVDVNDIRLIYQGQCLSNTKTIAEYNIQNDHIIHVVIRKKENINNSTYEKNNKFKNIDHDSNNNNNNNYASSTTPINDPLQYGFASSINFNTTDSNSNNNNNNNSNNNNNSNSSNNNSRPFGNTNIPTANIGGATPLYFTHMRLTRNDNLENDLMSQTNMCSLLNDIMSQVNINPNFIYGAAASAVNSVGSGENFFTANLRPNDANININEFRANKEKDQNCANVGNKQKEMDKDEIEKENENVSSEINCNDVKTGGEKGASNDNNDNNDDNGSGNNNDANGNGNNKHSREGRNKGKRNNSSSNSSSSENSSYEYNKNKKESDEEKKKKLKKKLKKKYMEKIRNKYSENINDIYSSSYSSDYESSYSEISDRKERELDDEKKKRHKNKILEKLRKKKEKKKKKYYYSTNSSSDYDKKNEKKKKKLRNKGKFMFDPNLLYNPNYMRNIYRGMCNPVQYNTPYITDINKGNYLRQNTKFNHIFNNNNNNSSSSVLRNVPYPYMNENDINKSMFYYDQKYGNISENENYINFKEDIPYEYENMKRFVNKKIYKREELNNNGKKRMINMNKNISDANNNNNNEVLFGSNFCNKTENRNINDAQNFIKNSNDGFTGGMLSGIAAQNSNNTATTTNNSGNNGNNGNNNGNGGNNNRSSYANIIPFSDIEVVRNNSIGSNSRSALSQEEEELSENNLIDEQMRSIQMASNNRRHLRSTSKLLNDENDFEYKNIELNIPWRIMDQLLVLLEEETGYKRPNLSSYINSYYNTNSIYVFFNLFVHINNIINSIIIQFNHSNFLNNDISMSSFSRISIILSLASVILSRLSNFFFVFYDNFYYNNYGRSYRYSEPINHEHLRELRNLYYSTNRNYNIRNSNISNLNYDQNNHFNNYRTNPNKTNLQQEFEDYYKNYLNGIDIDVNNNVLLRRDHPNFKTKNFDDNINNYKFKNEHKLSNNFIDSKKNKYNNNKSTDLKSRLKTDRDWNTNNPFSTLQNYNKNHNPLLYISKTKKKKNKKNAEKQKKNDKDISKNPSICSSKNSHNDSSKLGNNSSSQFGNNNNEPEIKNFPEPNVADSTTQNTKDKGNFMMDIFKNILKNESEEKTTKNNINDKNCLKINEKTNNTVPNTALVCYDNNMDDMYGTSDEEKEQTNKNINNEYKITEQKDSTNNPLSFEQNENIQKNDGKSNDGKSNDGKLNDEKHNSSNVDTQKNDKAVVNNLPIPNINFANILNDVQNQLATHKAPEAPHRDKFDGVPDKVKERYANWTENSQIFSGQMIKICRNKRPLSYVYLGENSLNDDISYNNPLPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNA7</accession>
    <name>V7PNA7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNA7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38998" checksum="CE5C8E7213A07E17" modified="2014-02-19" version="1">MQIDDNCEQNQKNVERNSFGIYIRLLYCFFSVTLLIGFSCIANGRKGIFYLLFSFCPSFVYLYLFKKKIKKRIKFSHIVEMILYGAILSIIFAGFLEYIFSLLCFYFCHTCFLKNVKESYSFACLIVILLYFFLGVAYVEEFSKICPIFFINANSIVNKNEYTELPIIENHNFKSDITYEDNEHNNKFNKFKYIYVDDKFEYIYFSLCSSAGFSSTENLIYFTLTSEDNFLTIIILRNIICVLLHMSCSGISSYNIINNQNNENRNGMMQSILSILRSLFLSSLFHAIYDYSIYYSSLNIPEYQISFFKALFMYSFFSMLFIFFVIIKGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNB4</accession>
    <name>V7PNB4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_02746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764238" evidence="4">
        <location>
            <begin position="23"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB60460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1485" mass="177664" checksum="8FF4775AF97772C5" modified="2014-02-19" version="1">MRYSYFIWALLLILSENVSIFALKCYNRNPVRTYIVVNLKGQNNKLVGKLLKNEATQKNRQKELYLKKNKKVMSLLRIKGNKEDDITYEEIEEYLKNEDVNNSDEDDGKKEIMKLINYIPTLKNEEEFFSKYGYKTFNSKRGNKNTIEYYLNEMKILKEKKEKKNYNILNLILSYYLKGPNDENNLPYNKYYQNIQSYYYYINSLISRQGGFLSSFTDRLDKKENIFYRTGLCNFLSFYLKNVNILKYGSFFCLSGIFAFLLKGIIRNIKFEDMFLLQNYFKLIYSIKSLSIYKIGIFSILFNSLFLNKYNQYFSISNDLFGMLFTNYFFYEGINNLTKKKIENFMDKYNCTKEDIFNSLNDLFSQFLNKQIYIEKEMDEKIIYNISSFIKLYKKLFINNIDNIKNITFLVLNKYNVYYTSVENINKTNSEILSRICYIFYIINILLKYNISSLQNFNLINNNEYNIPMFKSNNKLSNYFLLTSIKDHLMINENVINDCILDRMKKNYEKHIYSLIENKNLSTNIFDDIKKLEFLILDKSLINEVNLSIFNKLVNGILEKKNYDTPYFKHNQLASKENGDFSNVKSNIIEDTSSTGQLMGNNEINGDEQYLNNNVIKDDQNSKDDDDDIEKYYSENTNYEEEETEDIEGTDAEIYDDNENIDERMYKYIEDSVDYIVEGNVKKDEQNQETKSSNGKDNNNKSDEGEKKELETMLKKIKDIHSFRKYLSIPKEFVDNQLEKYLFPYMNKEYKIFLNNLIFKNFKNKNENLFFLKNGITLSSECTENIIKNIILDFVIKTKENINIFFKLDNMDKCLKLVLNLFYVYKKLKKKRKYIKTKNMILNLENIFSHNSFKGQTFGKQTISSETTKETTVTDYTDDTSILNKINDTKKNNVNENIEKEDYIDSDISFPNKKEEFLCNENFERNMREEEEGEEILSIDERKRLYEIFVLKYMKNKSERNIFKKVFKLDNVEIDKEVEDNIIKNFLEKVVKSNLENLKKLNSDLGIINNENLFDYKNLNFIDKLEKVKKNNKHDSNVNINKYIIKKDDIFEYIDDESFEEISKKMYINKLLLLKDNLYNNRKDLYLYEIILNINNSEGIHDIYLIDQYEKMINDIIKTNLLNKNYTNIKNMYLKKIINFLNISEQKATDVELRCIYDHIYSIFLSIKENFYIYKTDSDFFNNINEILTIYNNYDLIKKNGEGYLLKFALIETNHNLLQKLIERYVLYVIDIINNENKLTYKENIFKLAKILNVNNTIISDIGAKIYKKYIENQELHAMNNMDVFFNFLFNMDKGKQGEIILDYLRQKVQNHLNSNESYQEKLQKLYDLLNFINNNLKLNKNMFDFYHQNGEIIYEFLISCIEDYLDRKKSTTFISSQSDYMMHFNNFLSKIKMLIKGPEEKSHFTHVLNILKKSIIKKAISFMENFKYDLCVEKLYNFIKLQMIDNTFVLSDIDIEQRKKMINIFSYQNIDDEKKHLYMDILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNC7</accession>
    <name>V7PNC7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L3, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNC7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764489" evidence="2">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="246" mass="28991" checksum="4CC6F4F701CF4DE2" modified="2014-02-19" version="1">MHLYFIYKILIFPIICQCVYNYKIKNAFNFFETSNKLLKNVINLSYYFLSYTQGHSFYLYIFPEFFDNDGSILNNQDIAYPSKWMNKRKFQTHMIKKFINARVPFDPQTHLNDIPYKDELDRIQIRGKKIEMRSIFSPNGKLIPATLIKIMPNIIYRFLDFGKVGIAYGKPLNESRWILKPEIGQISKINSNLKNTCSLTLTPPQNFVLGQIIDVSYLYNYKYVNVRGLSKGKGFSGVIKRWGFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNC9</accession>
    <name>V7PNC9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNC9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB59843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="99655" checksum="2EE25ED7668F7BEF" modified="2014-02-19" version="1">MEVLPAGFSDFRSREYWNNFFQAFDKKNFEWYGSYKDIKNIVYECIRKRLNYCDGENGDIGVISPQEVEEGKQIFKNERVDKNCLLVNIGCGNSNLSYEFFEDGFDSIINIDYSDVVINKMKNKFGKMMEFINIDINNKECFENFLESLDIEKKKKKKNFKIFFDKAFLDAYISGDDSEEEVCKNNAKNYFESIFKYMNEGDIFIIITLAQYYIIKEVVRNIYNADIKLDVNPFLIKKNTNEFRYHPFVFSFYKTNIKLKDYTMKLCNFENNDYKIISLWKLPHEIRQIRDNLNLHSFKKGKRIILDIFNQNINKCEYNIIVYDSNVLKTVYNTVVIVVPFGYEFHSLYSTSEGNEELATKIKAKRLLLVMRSNFIINEFKIAHENNKSIANCESVKGGEISNTLESNEKREDNSNHLLNGNENTKNVQNSKNSLVSENKISNSNSSEFSAEASNASNLYDGILENQDSVSILLKSVKNELNKIINELALPNSKNFPIMALNEDIKNYKIICHEKSNYCSNIIIRDVLVTDEFISDNFGASEDNKTKKNGKNKKKLTPKNNTQNASNSEKGNDNVVCEEKNNKITHDDAKKLAIELIKKNTEEKKIYFQNKEIYKRQMIFSYDPLTVQSEIIYTKEKKKTNKLNDHEKIVFEYIESSSQYHVNFCCTFFLFILNNCYAKDNNLINICILGGGTNVLSNIIKSIFCDFNLYFNIVEIDETVQKLYKFFYDKEEISNDKHVTNYIINDSYEYIKNFNQPKYYDIIFVDMNNSENSYLNINGQKLYITCPHIGLLNKDVITDIKNILNEKGVLVINLLTRDNNAKKYVYQFLKDLFSSVISISSANKVSSKNKTIDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PND1</accession>
    <name>V7PND1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ferrochelatase</fullName>
            <ecNumber evidence="9">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_02015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="9"/>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PND1"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000002">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB61081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="300" mass="35052" checksum="C15F74795D1F64E9" modified="2014-02-19" version="1">MPRTRKMIYSQNDTLTKWYTHKMTFFLLNTGKSALKYKNIWTEKGSPLCVNTHNQYLALKKRLFEKYNDKVEISYGMRYGEKSIKEGLNILKMSNVNKLLVIPLYPQSAECTVASTLDCISKNLKGWQNIPELRFLSGYCFNEKYIDSIKENIEKFWEKNGKGKKLIISYHSLPVKYVQDGDLYPFFCIESTNILIKKLNLKKEDYMLVFQSRIKGQKWIKPCIEDVLKKLSTEGCDIIDIICPSFSSDCLETLDDIEITYKHVFQSYGNGQLRYINCLNYSELGIDMIMNIIEKNLSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PND4</accession>
    <name>V7PND4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gcp-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PND4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764313" description="Gcp-like domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Gcp-like" evidence="2">
        <location>
            <begin position="321"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="525" mass="60886" checksum="15BF4A6BED5EF94F" modified="2014-02-19" version="1">MKLRASTCIVFFLLFFIPCLFNSYKIDSIKITNLYFSDTLKGTVNKINKQFKNNYDDYDVCKYNKIPKILIDRDKIKKNNKESGYIVGIENTCDDTCVCIIDLQLRIIKNFIISHFKVVHKYGGVYPFFISSINSVFLKHYVNKILEGIDASKIKCFGFSVCPGISQNMDTARNYIGDFKKRHKHIKASSINHVYAHVLSPLFFSFYNDKNTFTNNYEYKNESTQKDDHTDHINMNLFDTIKKDKIQMDKINSLLKVLNNNDVTKKKLKMITADDFLNYGSYVLKKKKIDDNNIQLDETKNNINQIKENTNMEKIPLNYIQNGYICVLVSGGSTQVYRVQKDKQNDINVCKISQTVDISVGDIIDKVARLLNLPVGLGGGPFLERESEKYIKTLNDQKINEDISFDLFEPFPVPFAPNNKINFSFSGIFNHLSKIIKELKKEKNFENEKKPWNVYRTPINLSRDNAAMICFNTLLNMHNKINIHEDISEIKIKSTIKTQLQNNFLLLSDIIVFDVFLDYFDHNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>V7PND9</accession>
    <name>V7PND9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Flap endonuclease 1</fullName>
            <shortName evidence="16">FEN-1</shortName>
            <ecNumber evidence="16">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">YYC_03229</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with PCNA1 and PCNA2. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="16">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="16"/>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PND9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000016">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 16" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 16 21" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 16" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="20">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exonuclease" evidence="18">
        <location>
            <begin position="28"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="19">
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            <begin position="148"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="379"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETB59853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="453" mass="51558" checksum="279997C8E04033FD" modified="2014-02-19" version="1">MGIKGLTKFIADTAPNAIKEIKIENLMGRVVAIDASMSLYQFIIAIRDGDQYGNLMNESGETTSHISGLMSRTIKLMENGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLIKAKAEGNLEEIKKQSGRTVRVTKKQNEEAKKLLTLMGIPVIESPCEAEAQCAFLTKYEMAHATATEDADALVFGTKILIRNLNANASSNKNKNKNSSKRGYILTEINLEQVLKGLKLTMDEFIDFCILCGCDYCDTIKGIGSKTAYNLIKEYNCIENIIKNIDQNKYQVPANFKYVEARQSFINPKVLEKSEVKIDWCEPKIEELKTFLIKEHNFNEVRVTNYITRLLKARKVTTQRRLDTFFTTCTKKSTKLIIEESQKEVLKTKGKGKKREINNDSSTKLNAKKKKTNVKDEKKNNEKVDELKNKSDENLVKDEEDDQDDYDQNIFDEKTNSESDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNE7</accession>
    <name>V7PNE7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNE7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="279" mass="33165" checksum="24CB6643C4E861DD" modified="2014-02-19" version="1">MDPYKFNSWIRILISLCSLGAYILISLMMPLYIGKSNFETMYGIHFVSPYNKGKYITWNKYETQICDNKRAYGVPKKGNPFQENTAAMLCDSVFFLKNYLLIVFIITIINMLLVKGVLIYTHFKEHPETFPLKYVKYCNKLIIFIMCLTIINFMLFTSPFFFFNYHNEFGKTTFAYPGYYILMGDFFSHFIIILFIKRDKTILKCVCELEVLPWERKQKATFHNVVFNDTLISPAEITNYLHNMFHEDNINEDQLKNLFGTNNYEDIYYMIMNNIKMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPD3</accession>
    <name>V7PPD3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPD3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="885"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="963"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1004" mass="119853" checksum="37B9DB8DBE5FCE0F" modified="2014-02-19" version="1">MRKIKKDEIVNVLFTIFLVMIQQLSLLYIILNNTNNYLYLTFLAIDIYLCIYMLWSLYDYNNAGVKISIEWMLYMITLSLKMIIFCFVIIQIEKAKKGDNPFFIYLGNDVLVYNLIYMTPFIYLLFSLRSRNILEYILSNQIIIENILSIDVNIINLLDIIDLTFMYSHLTTIYKILSDTEQYNIQKVYFMLVIVIVSMLLFSFYFPIYTNIEKSYSYDDIDINFVVKNKNIRKKRPDINYQDNFLKTENKFISKKPMLLDAKGGQTNGNETGINNISRYVNHAKTFLNIYDSNKKLLKMTNTIKYKNNDRSKISEKKILFSSSESIYSQKSISTTPSSFYSSNNSNDILSENIFSSTTSSNTSAFSFELSDYSKSNSNDLSITSSSSQTSSSDSSNSPIYAYLPSFFSFASKNRKNNNSYNKKYRDVYTDVYITAKFHFIVGFFLIDVPFLIYRLYFCIKYKVVLTLVIKNVLFLLFRSFKLNEYRLVEKEKHKKNKSNFDFHFYNTENGDNENNDYGQYGDLNSSEISQFVYKNKKSVILDDRNNYKRWKYRNSMRTFKNKAINEMSKMKSKKEYAFLKKKNNKKYLKKKKKKIDILDIFKEEFQENKQKIILEKIAMKNKEQINMNTVYFDKLGNSVSSVVYEKGTNNSISGQINNSDLYNYDNDNYDKIGKNGENKESKNSTKVKFSWREKIKLRKKYKTFINLIYKLKYKREIPIYRFTIKDHITELYNFIFKKINCSNYVFFDDKLVFSYFTNMKFMLIIFLDYLLKIGVTIFFLFILLNNHTFINKQNINYFHDIPIKHNTSHPLLFPQNFDFSKYPNIKLPRNPIHIKYINKDIGNTYSSTITETIPGIIPNGYLNLNIRDNIFTLKWSEIFIYDKIYIYACIAYFFLYFILLIKASTFFDVLFGAIFNTIRNLSYYFSLKQFILFFYTFNGNIYNKNYIYQDRTIRKLNSHLEYYFLLFFNIHYFISFIKHISLYLRILFNFKYVYYYRNLPTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPD5</accession>
    <name>V7PPD5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_01370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPD5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB61491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="217" mass="25590" checksum="CAD62799A2F4228D" modified="2014-02-19" version="1">MEYEGETFHLTEYQINKTIKAFKYLDKKKRGLLKFELLGKLLRCSGYNVSLQEIDKIKMILKDNKIKASNIETNEKKEDEIVINEDKEMIDNNMTNSQMKGTNENDESSNISKLLNNLKNYDNFMELEKQREELKRKEEEDKNLFSIKEFFRIIQIPNITNEIKPAGVLNAFEIFDEKGDGKISIKKLRFILQYLGEPLSNSEFDEFFEWLKTVSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPG0</accession>
    <name>V7PPG0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204:SF0">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1405" mass="162856" checksum="CB28F1FC597A9F17" modified="2014-02-19" version="1">MEEENIKIKVKSIDNQECEFCVKKNTTAEELKNMISEKKNVDVNDIRLIYQGQCLSNTKTIAEYNIQNDHIIHVVIRKKENINNSTYEKNNKFKNIDHDSNNNNNNNYASSTTPINDPLQYGFASSINFNTTDSNSNNNNNNNSNNNNNSNSSNNNSRPFGNTNIPTANIGGATPLYFTHMRLTRNDNLENDLMSQTNMCSLLNDIMSQVNINPNFIYGAAASAVNSVGSGENFFTANLRPNDANININEFRANKEKDQNCANVGNKQKEMDKDEIEKENENVSSEINCNDVKTGGEKGASNDNNDNNDDNGSGNNNDANGNGNNKHSREGRNKGKRNNSSSNSSSSENSSYEYNKNKKESDEEKKKKLKKKLKKKYMEKIRNKYSENINDIYSSSYSSDYESSYSEISDRKERELDDEKKKRHKNKILEKLRKKKEKKKKKYYYSTNSSSDYDKKNEKKKKKLRNKGKFMFDPNLLYNPNYMRNIYRGMCNPVQYNTPYITDINKGNYLRQNTKFNHIFNNNNNNSSSSVLRNVPYPYMNENDINKSMFYYDQKYGNISENENYINFKEDIPYEYENMKRFVNKKIYKREELNNNGKKRMINMNKNISDANNNNNNEVLFGSNFCNKTENRNINDAQNFIKNSNDGFTGGMLSGIAAQNSNNTATTTNNSGNNGNNGNNNGNGGNNNRSSYANIIPFSDIEVVRNNSIGSNSRSALSQEEEELSENNLIDEQMRSIQMASNNRRHLRSTSKLLNDENDFEYKNIELNIPWRIMDQLLVLLEEETGYKRPNLSSYINSYYNTNSIYVFFNLFVHINNIINSIIIQFNHSNFLNNDISMSSFSRISIILSLASVILSRLSNFFFVFYDNFYYNNYGRSYRYSEPINHEHLRELRNLYYSTNRNYNIRNSNISNLNYDQNNHFNNYRTNPNKTNLQQEFEDYYKNYLNGIDIDVNNNVLLRRDHPNFKTKNFDDNINNYKFKNEHKLSNNFIDSKKNKYNNNKSTDLKSRLKTDRDWNTNNPFSTLQNYNKNHNPLLYISKTKKKKNKKNAEKQKKNDKDISKNPSICSSKNSHNDSSKLGNNSSSQFGNNNNEPEIKNFPEPNVADSTTQNTKDKGNFMMDIFKNILKNESEEKTTKNNINDKNCLKINEKTNNTVPNTALVCYDNNMDDMYGTSDEEKEQTNKNINNEYKITEQKDSTNNPLSFEQNENIQKNDGKSNDGKSNDGKLNDEKHNSSNVDTQKNDKAVVNNLPIPNINFANILNDVQNQLATHKAPEAPHRDKFDGVPDKVKERYANWTENSQIFSGQMIKICRNKRPLSYVYLGENSLNDDISYNNPLPFLWKKNMSNINASFDLEIPDELVEAFDMHILEHVKKSIKNNEDYKLEKFKYPNLSKCEELFEEADKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPH6</accession>
    <name>V7PPH6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-seryl-tRNA(Sec) kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPH6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052648">
        <property type="entry name" value="Ser-tRNA(Sec)_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873:SF0">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="68408" checksum="E5EA2AA213DF6023" modified="2014-02-19" version="1">MNFILLFYGPPCSGKDTLIRFLIKKKKKILFFIYLLYNLKEPYISYKYSYEQKFFIQLIKYCNKINKHFKLNNKYRIRKINHLSFFSLINLYKTFFITLSDSTFHSNFQTSLNTIYAKLKKVKKKKKINISSHTHSNSNNHSHKNDKINVTNVCIKISRKKIINNVTKPKTFFIFYKKFIKQIKYFRHFLSKCKTSIHNISTDSIEKQFYSTQNEKKSEKKYEKKYEKKSEKKCEKKNIAVVTDKIIIFEKQNYKTKIYYPIIKKRCLKNKLFFLSKAKENKNIKPTLFNQKKYWKIARKIAYLYCSHLINAKKNAKTDTKKKTKIGTKKKTKKGASTSTQNGPRLKHDQNKIIILNDTFHFPSMRKKYYLLSKKYNSLYIQTFLNTPVKLCIQLNINRNKFKYISKETIIKNYLYHRKYAVALKNVPKNEPKNEPKNEPKNEQKIINFVKATRKWQANAISIQVNRLENKNKLTDLLFFIYKYFPIFIKEINKKKTVTKKENHNPVIQTNALEIINKTANKIIHEKLKSVPNDQKNAYAQKYRLIKLQLLKECRIAKTFNVTDIENSFLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPH8</accession>
    <name>V7PPH8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPH8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="90" mass="10829" checksum="FDAF6FF0657CD2E0" modified="2014-02-19" version="1">MKDNINFSNIQLKASKFFDILGSTRLMQNLNASNHGSYIYRYVHNVHDHNENNGAVLVFFLFFIFIFAILFFIFYFIFKRHVNHIRYINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRH0</accession>
    <name>V7PRH0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="896"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1491"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1736" mass="205612" checksum="C0947E4035607B9F" modified="2014-02-19" version="1">MELHKLLENKLSIEESQNINTKEGDMHLNTINEDKKIATEKGCVLKIKNCDNEKENLPNSSYENINIKKKGNDLQYYNDQKYDTLNNALTTSESFNNIKIKKKCYEKNDDTINLDITSSTENLYHNINYDYIDKQVHNLLESGNSSDEQGEIIKDEKEQIKTKIEEDEIENNEEMQGLKHIEGSLLFSSLSNDEFMKIEKNESIPFHSDEIDFICEDEMNNIILSHEQKISTFTSLLNDNEKKEEDYANYFRGRNENSIESYNGNGNESFDSNIKTGKSTKECGELDSEDDKEIKNILNILQNLRDYNFNDTNAIDNDDNYENMEEKDELNNTEHSYNCENEDNSNTKHDDTIIHDKNIPFLGTDYIPNDIASNKKDINSTNDQTGSDEDKDNIDHLNIKKLKDKYKKYVFSLSDHDEYQRSDRSVQSQNGEEPIEETYYNSDTNIKQKNESDKCQEDGNSSNTDNIGENQYNYKHISGMSNIDMNETPISDSNNNFDKMKNHKKKKKEETIEENELKEINELQTDSYDKENPHNNLTNEENLEYYNLPVKPNVLHIESQESWQNKISATSDCIIDSKHSSVSFYNHEIGSFAEIEKERNDMYTKVGNTENNNNNNDNETKDETNNKKEIEETWKPSEIKNDIVNTNKSSKNEENENSEQMRKRKLIKENINNLRNDNKNLKIIDELNQNINNLNFEYLKNNEFNLDINYTNDTMQNVSIQKNNNISEKIEKVEITNNNLLDENLNFDYYLKTLHNLKSRIHQEISGNDSSSNSNSNSLNKKDITINEEKNENKAIQNSDEISAKKERENDNNQNEKSRNTEYKEITNNNFQKEPNEPSEKKIIKDKHQDKEEEGKEIVLKKKVKKKKKTKRQHSLDNNEKDVSQNNTQIELVEKNIILKNTVKDLQNQITNYKKMEKLFDKNKKKYKNKLAIINEYEKKIDCIIIDFNKLKDKCTNKEKKISKLEEVTKYMNEQFSISKIQFENKMNEYVIFLKKKDSEIYMLKELIKEKEKVISFNENILKQYKADIDDMLKQNIERVEHVKNKLKIQQNMISEKDLKITKLEEDIRVNDAKINAMENKIKALQNQIELEVKEKNELKKNYEKENKEKDALSKKLDEIVKEKNNLHYKIEELLKTEKNIIDDKAELLECKNELSIENEKIKFEINTMIIEKEKMEEKYNLANSKKDQINIEMEILKKTYENNVNELEKLKEDFKNVQKNYNQLKEEKDRIEKSYSTEVEEKNKIQNSFEATKNELATRENQKELLQNDLNNLQKYLDETVTKNEEEIKGLKKQLSELEEKLEEANNLYFKEKEVIEKLNKEKNKFIKEFDKLKNKNKKITSKMKETQISNEKTINDVIKEKNESLEKEKSKFTEKVQSLEQAFQESYNELHCQKKNIQNELEELKIINQDIKNNSKNLLNVNDALVKEMKAYNIEKEQFIKGLKNIKEAYIKIKNENQQLKKNAFSFIQKDIEQNYVPINIHNTVLNEKKTYISEIDILKSKVKKSENDITNLSKEKSELSEKLKKINQQNEDLNTNIKVKSKITEDIMRTVEKLKSDITNKEEEIKKKTLEIKKMEREYKTLLDDYKMEKKNLIAKYENELDEYMNKCEFAHSKYKKYEEEVKEMKSKLKMKDEILEYTHKEIENIKESFCKEYEHKIQAVIEEKDKEIHAMQKKFKDLNEENTVRNHHKIHICIYIEGNIKKMSPNASIQSIRHIYISFDIFFRKIKTKLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRH3</accession>
    <name>V7PRH3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRH3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF613">
        <property type="entry name" value="NUCLEAR RECEPTOR-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="297" mass="35378" checksum="7B08476DCB35CFB1" modified="2014-02-19" version="1">MGILCSSNEKYTKYFHRGYLINPDTNVNDTTDLYPCVFLRSGEKRLVKKIDKNKFKGEILNSLLKLRTYTYKNESSLPKYLLKTYNIYKDDKFSYVIFENCTGGFFFDILKGNNVINENILAEWFYQILITLNFLEKRNIYHGNLNGYCIHFKDKTRKEIRLSLLSINNYYDNIDEKGDLYGLYCIRSPQEIKKLYHDKNNSWYVGMLLYFILHGSYPFINNNVLVNYHNIIQNNIPFAALKLDHKNYSNLMYDFLKSALEKDYDMRPSVEGLLNHPWIKKKGEHPIYEILDENTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRH8</accession>
    <name>V7PRH8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_01778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRH8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.80">
        <property type="entry name" value="Cathepsin C, exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036496">
        <property type="entry name" value="CathepsinC_exc_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75001">
        <property type="entry name" value="Dipeptidyl peptidase I (cathepsin C), exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="172"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB62034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="439" mass="51656" checksum="8775C9C5F4E7D22C" modified="2014-02-19" version="1">MVYDEGFEIRLRGKRYFGFFKYDKKVSEECPSIVENINKINTECYKTDPTKIRLGWIFYERKQKNDKEKIYQWGCFYAEKITKMPISSFVIHNMNNSNKEDNNFVNNKEHTDTETNFLGLMQKDNYNKIRMNHPGLFGSTKISYIDRHGGKERGIYGCKKRESKKMEMNLVLPKEFSWGDPYNNKNFDEIVEDQKECGSCYLISSVYVLEKRFEILLSKKYKKNIKMNKLFYECIINLSQYNQGCDGGFPFLVGKEIYENGIHATMNYGSLDNKISSKIEKFSRNKKNKEIYYASDYNYISGCYECSSEYDMMREILNNGPIVAAIYATSSLLKIYKLNDYNFIYTTISDENKICDVPNKEFNGWQQTNHAVVIVGWGEYINKNNKLIKYWLIRNTWGNHWGYKGYLKYQRGINLNGIESQAVYIDPDFTRGSGKDLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRI1</accession>
    <name>V7PRI1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_01918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRI1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="9">
        <location>
            <begin position="68"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB60963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="134" mass="14232" checksum="B22BC4BD858AEB9E" modified="2014-02-19" version="1">MWLQNKVNIISYMFGHFIHSLGMYGVITAVFLQIKFSGLKTEVHSPLVLTPQTDPLIMNSIRGGWALFASGLTAGLSNLVSGVAVGITGSSCALGDAHSSDLFVRMLMIEICASVIGLYGLIVAIVSIGDIQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRI6</accession>
    <name>V7PRI6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRI6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="708" mass="83853" checksum="EBAB2259BC8594B1" modified="2014-02-19" version="1">MNSRSYCVFFYTILLFVYIFIIYYLNKYERHKLPVKRLDNVLGYIQNVHKNGSYKKNIIENENNLNNSNLIIEIYIVCGCKGKISSNVLGSKLKEYMDKKIILDIKKKEDDRLDYFIKENDLFDIKLDLINFDKIQNYEHGKYSNICKNSDNNFIKNTYYIYIDENDEKIRESHFILSTSNIIEMLHKKIEINKEANIYYEKFVKEAWNVIKNFIFFKSHNRLLNFVPEIDLNFYLASSLYSEENYKQGENTEYGHKKGRNETEVNNNGDNEDDNEDDNGDNEDDNEDDNGDNEDDKSGGNSDNISIAALDFYADFYYPYMQDFVEKLLNIFQINIYQQTISNINIYKISEKKNGKYIKDSEINKINNKTRLIILDKVTKITNVFDDVIFSNILKRPTYEIPKNINLITIFPNEHDIYFYNNFENKIETAASFIEWGIIYINNSMVTDLKRQRDKINKKIVNVSSQANFISSIYISHLRKFLGLCSNFSDYVYNIFNPNKYDIKNLNTISEEDNNFIIYSIKGKDDFDFDFDFLLYYNMPLKSRISDYETLGLMREAFTHYINETIKNMNKFISISNISIYIKIPKSTVYVFNNILNNLECSIYYMQGKKCEYISDINETIIQKFHSYMKHDELENNSISTDKNEDSNNKNNSMNISSNKMGIYYKIGLTLARAAYQDSLQRTVQRKKQKDSEWKLRDKILTSLYILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRJ2</accession>
    <name>V7PRJ2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRJ2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="97" mass="11620" checksum="E44B5FAFBA91D45A" modified="2014-02-19" version="1">MNVDIAFDGNEYTYSGYSKNSLIEDKNYTLDYDKYVHFAFFVCYYISHIKKEKCSDTELLTWYLKTFKHVVINSTKKVKRTYFNLINNLIQDKCVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRJ3</accession>
    <name>V7PRJ3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_01273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRJ3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000049">
        <property type="entry name" value="Eukaryotic translation initation factor 4 gamma, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="623"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB61367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="916" mass="106780" checksum="5548B8FC5B57B146" modified="2014-02-19" version="1">MNNTNNSTEFNKSNYNKNMNNSENQKYNFNRNFKNNYNKNRNNFNMKHGNTNTTSGLGDEMNNNNSDNRLSMNNPSNYANSEMNQNNSKMGNSSNYNNLPDGNFNNNMNNKMFFKNNKFNKFGSQNNTDSSNNFNNINFKDNKQNVNYKKQYNNNNPMNRNISMDENMNYSNMENENNSGMNNSPNYKSKYDNSNTSNVIKNDMSFREENIKYYGNNHNSPNNNLPPNVNMHNNNSSREHSRNPFFMNNKKNNMVNDNANKNNRMMDFMNNPDNENMNQPNNTYMQNNNYNDVNNYSNINISNNYMNDNNLKKNIDSSNLPHMNVMRGNNNDDGDFVKREFTNENNNQNNNQNNVTKNTTGNMDASTYIMNAFAAFNNNSTNNSNTNNTNNDNDKNVINDSSNNNSNDKRSDHMNAPNNKSNNNGDEEFDEWGELGEDKYIDINSIIKQKNVILNQLGANLNDMTKKGNDNKNKKKIKSKKDNPFTPDNLNIPTTSLASDKKKNKRNKNKNGKNDNNTKENNNMIDKEKNKQNANNLANKKKTEKTVNTTNNSTQQKNEEKQLDNINNNQSNIPQNNETVEGAKEVENTENKNEEPKEEPAKPSKAIYVFKKKENMHPLEFMKRQIKSLLNKLTVENFPIITEKMCQIMDSRINTDEIQTVVNEVINKAVLEHDWSEMYADLCQALKWRSPNFEMKKKSSFEIALLKKIQEEYENLPSTFESTMKEKLKNDENEEELSFAEQKQKKRLFGIVKLIGELFQRQIVSISIVISITHDLLIAYDEPKEYCIEAFLQLIYSTGFFIDKMEKYKNVLDTWFGRLKELQRKKMYSKRIKFVIQDVFDLRLSEWRKKTHKDTAKGLNELRSQLETEEMMGGSIHLAQLGNIVIVGERHNIRNNESYSKYMQEQERLSKLNQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRJ4</accession>
    <name>V7PRJ4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRJ4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="397"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="737" mass="85166" checksum="3469D93B0FF2034C" modified="2014-02-19" version="1">MLNNINNKIKDENKLSSMSNYVDRENADIMGIGIKNNYMTINNYYGEKTNEHIYSNGEYINNVNDNVVKKVGYINYNNMTNELPKSENWKNIEEYNNDLNKNKRNNPIYNNINNNIEINESIKKQKIINDDISYYSNPNMQYNNIIKTTTNQEFEEINQWNNLNSYVENETYHIYSQNSNNKNNNNNSNDSSMYEYQTVNGIDGMNLNNNNINISSKYENISFPMKYENNPNEWYMTSDNSDWVVNKECNWLYNFKDKLYFNIKSQGIYFEENGDFFLVDNSIDKGEKENNGYSEYIYEDNKNKCFETNVKKSYTNENEDIQNSGDNNNYSSTNGNIQKQYLNEKMIIINDSANINNMNGAIMLSPSNVGHADNNDHADNNEETVEEFSMVLEDDLVCGTCSKIGSHNRNENEDFYITKDILDLNNVSENDSLCFFSAVFDGHGGSNCARYVMSHLKTNLIAKFRQSFLITCKKHYKEKNTKINELSVAIKALYDSCIKGFEMTDKNYLELSKKYDYKDGATSCVVLIYGPDEDGSLKVLCANCGDSCAFICHDRKPIKLSLQHKPDLQEERIRILRCGGIIANINGINRIITKHKDKNSNNREKTFLALSTSRSFGDIPYKIPKKIVLCKPFISVYTIDFDLDSFLVLATDGILNVLTDVEIIDIIWKNIHQTPEYAAEEVVKEATKRGSTDDKTCTVIFFNWRKDIFNKNTKNMNFDQVPQDDSNPEDINMFSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRJ9</accession>
    <name>V7PRJ9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_01939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRJ9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB60988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="164" mass="20329" checksum="1C9D9333FBCA7220" modified="2014-02-19" version="1">MNYHKILGVTRNACKKTIREAYLKKVKLYHPDLNKSPDATTKFKQIQEAYQALYNDNYSQKLYDNENIYNQRTNSENKKNNKNYNNYNEFNDFHRAFYEEYRRMTKQEKHDEYARYTNNNSRYSINDIFHKYPREFFYINLMFKLFPLFVVPVIFLFVVYKQYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRL3</accession>
    <name>V7PRL3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_01805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRL3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB62074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="116" mass="13644" checksum="7E252AE63738DFBF" modified="2014-02-19" version="1">MIKGVLIINTNGKPRFLRFYDGSSHERQQLITKKIHEIIIKRSTDESCCFIENEELFGMDVKVVYRHFATLFFVFIIDSMESELGILDLIQVFVQVLDVNFENVCELDLVYNYEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTK1</accession>
    <name>V7PTK1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein light chain Tctex-type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTK1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10827" checksum="BF91F43AE823705F" modified="2014-02-19" version="1">MYSNGEINKWSNIICEECMKYLYSKMLPLKYIISCYILKNSNAETSIQYSTYWGKDDRHIQICWPHDQNNCNMLCYINVYALKVSDGSVAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTM7</accession>
    <name>V7PTM7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein S-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">YYC_01369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 15">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="2"/>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTM7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="41"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETB61478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="920" mass="108759" checksum="9FC8426558FD3460" modified="2014-02-19" version="1">MDPGIIPRQNSVLNLYDAIIDQRRGAQPPKQKEVLINGVFYKLKYCYTCNIYRGIRTVHCSICDNCVEKFDHHCPWVGNCIGARNYKYFIYFIFNLYILICITLAASIYKLTICMTALSNKGYNSEKIFIHIWSLATDSIILIIYTVLTLWFVIGLLCYHIYTIVTNQTTYEQIKTFYQNDNPFNIGVLNNIKEILFTKVRPSYINFENPKLQVIDQYSSHNIITYSDKSISIDQGIANISLPVSIDDKESNIIKDDIIDDDIHYEIEMKTDSQLLKNHDDEFIEKNKNLTNKNAFLSTERKSLKRVKEYNSLNSLGIDTESKSNNFKNKRISKKKTEDVDSPKINIISNRGIGKTVRSKDYKNKIITKISKIKLIKTIKKNLSEELNNDIEINNYQDKCIIDVNNNLGSLYIKNDVSSGSKTNNEVFSDIDNELDGTYYYSSRANNLADINKRTNEKKKKKQNKKYYIISIKNWEKNNTTTKIVENDKDYYNDNNNNDIYNMNTHKEKMIETNKIHENIHESKNNHYNNITRVRRKVEYKLLFKKKFPFILKHKNKIQTFYMIRDPKTENKSIHPYSTGNIEHENPSEILCMDNISIEDNEKEFKKINYFKKKNYHKIHQSNYSETNTNKLKNVISEKYSNSDFLNDINCNKYDDTNISNCNVKHGNLGKRESKESNKKLNRKRKEESIIDIRKNVVLCIYNYNTKGNSGKLPDKEKKITNLEKKNNLECKNVIYNIRDKKEKLITLLKYKRKGKKKHDSKISLAYLSQINNMDFDNFSQIYKRRYTKIYQWKCKKIQQEIIRRKKIKLLSRSSHKNIHTYYNNNKYFLENLNNLTDFQINNNELIKRYYQHDSLYSTAIKYNQFDNVKLYSYLTHMKNAQNRSDIKKKSKASKFFDLFTTFALIINCINIPSNNDNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTM8</accession>
    <name>V7PTM8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_00565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTM8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="318"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="417"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB62946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="578" mass="68054" checksum="6665CF5662C970F8" modified="2014-02-19" version="1">MEEDNEHFDEKETTLDKKKNKKNINGNVKSQINDDNSESDENNSNTEEESLLKNDKRRKQNAKEKGNKSNITRRGRRKGEESEKEKEKEKEKEEYTDTDKDENSNSSEDEVPQKNKNKNKNKTELEENDSKHFSEHSEQGDQEEEQSDNDENEKRKKEKYKNIKHYNDEGNSNSNRDKSSDSESDQDERNRKREEKSESYKKDYHKKRRRKSHSSNDTDSSDDDDDEKRSHKSRSVKKRRHERRERRRHRDRSRGRSRDRSRDRDRERNRYRDRDRERRRERERERMRKEREREIEREKRREERRKKEELEEAKRDDLTVLVLNLDLKADERDIYEFFSEVAGKVRDIQCIKDQRSGKSKGVAYVEFYTQDSVIKALSVNGYMLKNRPIKVQSSQAEKNRAAKATKHHPIDPNDIPLKLYIGGLLGPLSNITEQELKQLFNPFGDILDVEIHRDPYTGKSKGFGFIQFHKASEAIEAMTVMNGMEVAGREIKVSYAQDSKYLLASDALKDLNIPNLNQIKAATQGGQKSTNKEEEQDNEKIDNDDDDGGGLITGASSKIALMQKLQRDTIIDASVRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTN7</accession>
    <name>V7PTN7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Palmitoyltransferase DHHC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTN7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="95482" checksum="4C7DBEC624384A90" modified="2014-02-19" version="1">MTALSNKGYNSEKIFIHIWSLATDSIILIIYTVLTLWFVIGLLCYHIYTIVTNQTTYEQIKTFYQNDNPFNIGVLNNIKEILFTKVRPSYINFENPKLQVIDQYSSHNIITYSDKSISIDQGIANISLPVSIDDKESNIIKDDIIDDDIHYEIEMKTDSQLLKNHDDEFIEKNKNLTNKNAFLSTERKSLKRVKEYNSLNSLGIDTESKSNNFKNKRISKKKTEDVDSPKINIISNRGIGKTVRSKDYKNKIITKISKIKLIKTIKKNLSEELNNDIEINNYQDKCIIDVNNNLGSLYIKNDVSSGSKTNNEVFSDIDNELDGTYYYSSRANNLADINKRTNEKKKKKQNKKYYIISIKNWEKNNTTTKIVENDKDYYNDNNNNDIYNMNTHKEKMIETNKIHENIHESKNNHYNNITRVRRKVEYKLLFKKKFPFILKHKNKIQTFYMIRDPKTENKSIHPYSTGNIEHENPSEILCMDNISIEDNEKEFKKINYFKKKNYHKIHQSNYSETNTNKLKNVISEKYSNSDFLNDINCNKYDDTNISNCNVKHGNLGKRESKESNKKLNRKRKEESIIDIRKNVVLCIYNYNTKGNSGKLPDKEKKITNLEKKNNLECKNVIYNIRDKKEKLITLLKYKRKGKKKHDSKISLAYLSQINNMDFDNFSQIYKRRYTKIYQWKCKKIQQEIIRRKKIKLLSRSSHKNIHTYYNNNKYFLENLNNLTDFQINNNELIKRYYQHDSLYSTAIKYNQFDNVKLYSYLTHMKNAQNRSDIKKKSKASKFFDLFTTFALIINCINIPSNNDNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTP1</accession>
    <name>V7PTP1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTP1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004765706" evidence="2">
        <location>
            <begin position="23"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="996" mass="119325" checksum="0DDD6A0B8DA2AE91" modified="2014-02-19" version="1">MGNVIYICVFVFFVISLNCSNGYKRINKKPYFFVNLRNCNNHNNNNNNMFNNNMLNNEFFRTNRYATKIKNKLNNIKNIHVGELKIGKIYDIKDNNIYVKLKNDSEDTVIIKRENNYLLENELLYDYLLNKNLIDNKLYSKLIKKKSNETEEDEINKNNSNKTDDCIVLIKEINSTKKIIGELYTNEIRKRKEKIYDKLNELKNIEQRIFIKILKNVRNKYFIVLINDCIKGYLLYEENNNDPEYSNLLNSKETQLSDKKLSAYIIDANKKLEYVFLSLKKYPKEDLENKIQALQHNIIIENLFENNYFKGEISDFCNDGNNIIVKIFDNKKNDIKVKIKSHNIINTKNILRNFDYLKNKVINNEFLMRTNYSTQNYKNAEDKTINYNKTTTQREYYDDGNIANTNKNNMSPFTKKEYIDNFKKFKECYYGCSDADALKYINVDDYIYKKENVIYVRIINKTLDKNLYEGSMKNCDIIDHNIYELLKKISSKNNIITEYNEKLRYPSKVLGFFNNYVILSTKILNPDVGYKDKESDDISDNNEEKQINQINVSKHQDIKDIITVIEKRYIDYENLKIGDIFFCRFDSVKRRNIRNTFNLSNSEINKIFHSYFRNDKDFITQRRREKNVYPRFSTDSNLENIVIDSYTKLDGDVSDNLPIYDDNSLEEEEQENNYNEQDKKKNKIEKNLSQQNFEQIFFEKHNIYMMRTEIHEDTEYHLNKNKVDKNFKTLRHICDNYYSGINKAYSRYPSIREEYILRYLGKDDYKLYRKIVLEYFSSNENSYKELLQTDCEELASSIFDLIFEDPESLTIEIIRNYNKELFEKVEQLNIYELNFLLKDLIKLKNKLYIYSFAHDTKLGRMNLLLNNQKPIKKDHILNLKVDELIKQELLKKYNNIIYPIDYIKNLILKKKKEEYKRNSKMPLIYILADETINIYENSAKNVKPFTEKEIEAMKSHIMKKKKSLFAPSNDQDDDFRSSLFDPENSQIRHILHMIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PU01</accession>
    <name>V7PU01_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_01460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PU01"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB61603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13491" checksum="3E6CA835630F2D5F" modified="2014-02-19" version="1">MASNILFEDRFVISNVDNSKFEKVSRIKAKSTGYDAELILDVHSELFKVEEKKAIYLALQDNFMGKNDEKTWEQTDNKSLNNIEYIMSGRIFKFEELSSERRFTFMLSIFYHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PU11</accession>
    <name>V7PU11_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PU11"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052111">
        <property type="entry name" value="Spermatogenesis_Ciliary_MAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509:SF8">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CH-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB63099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="575" mass="68311" checksum="F88A11ACEB3B3424" modified="2014-02-19" version="1">MELPREVIKWLQHLNLPYSFKNMKNASNGIIVAEIINTYIPQSINMNNLENGFSKDIKKKNWKFLKKHLESFNILFDEISIINSDKNYFINLFIQLYEFFNEKKCQNEYYYTNEEGDHSVPSFSKPTITQKIRESAVHDIVDEEKRMMRTYQIIKDAQYNIAMEKERKKRENQNKGEKEKKKTDSNDTHLFNELEKNCSIITINDISDYVGNTDIKTLDSFIKEKDNLKYLTVMNTIKGKISNEKKQTPNQNYEDKSVEEIIITILSEYITDYKMEKENDNEYVKEHNKKIKDISKYHEFKLYEDKAGDNLYANFQSICFLKEYDVIKNILDTLKNFNENFSILLSLHPDKFFHIWKLFFPVISSSTCDNEVFILIMDYLKQLLNYLYIEDLTTKEILCHVILKSLFIIDKDDYKDARCFCELIILIIKNDKHILMNILNMIKNNMSLNFFYLYLSKLLKMSTNWVLYEKDIKDIYLYYIFIGLHANKETIILCCLDMLSTISMHENCYDILPFSSVLYNILEMKNISYCIFTFVVSANIVSKLIGNDQNNSGHNAHINEFIKICYTILENTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVQ6</accession>
    <name>V7PVQ6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">R27-2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_00846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028745">
        <property type="entry name" value="AKAP9/Pericentrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981">
        <property type="entry name" value="PERICENTRIN-LIKE PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981:SF2">
        <property type="entry name" value="PERICENTRIN-LIKE PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1017"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1311"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1345"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1479"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1834"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1589"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1017"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1084"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1170"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1226"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1350"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1480"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1848"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1878"/>
            <end position="1887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB62233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1887" mass="220622" checksum="4C35B1082DE4C702" modified="2014-02-19" version="1">MDKTILSKKEKIKIVCKKINNLKKKFYNSAEHLKCVEVLFEKSGTKCIKKKKKNKQSLNLEHNDNSSPTKDIFFTGFINDLDFFNAKNLDIFFDKFRFLNNKYNDKQKNSNLNFNSVHKNQNAKKAKLKKNKNNIEEDLSNKSNNTENEITFESSQCNIKYIKLNSREPDENEKNFQVENKMNEIKNNDMEINAENIHCISKIISNEDNTNDNKRRETKLYDIDSYNNISNKKRKLSEITVDMNNMSSELKKIPKQVCTQFSLEEHQDLGNDYEKKENHTKDEEDQGIYSKNKYIKKQNLILKISNIIFEGGEGEKTNETSLLFQNNTKRFNFLFENMESNHDKKKNIDDNIKKEYEYIVNQIDVIVNTKSQEKLENKITNYQNDLQKCLMFFNNIFLKLSVHINTLFSTCIELLKYDFSHLNCYKLTKLNNSRKVINLIKRYQNYQEYVIHFSNYLLQICKIFMSRNNSEIGYFSGKYIKDIISKKEIKTIKNLITILNKWNKIDLNILLKLTQYKMENNTNIYQLKILNYDLVKYNFFVRKADFLKYNNKIISSLKRICSLLFDGQLNEKMKKNKNGENGENGENGENGENDKNDQNCEKDQNECVEVAQSYDFNINNLLKECNKFSKINDSNGKNEIYQNQRNGESSSDGSSSSDGDSSSDADENDLYSKCFDNEEILEYNVWKYEREMKSNEMKVIINLNKILTHEMSYYEFIRNATKREIDEITNIYIYIKKIYNFLEKNNEKSSSFDLPSTQNEYLIINKFREYLLELSINKNNKEIYMTNDTTHCINNKNKNIPIINNEENGHINFSIIDDFSLLEKYNIYNNNKVVKDKYSKDIFESFEQIKQNKYTNNSLEGKERFKYISYKNDNDIYNLANMIKTILVFILKCYIKNYGTTNSTIYEENAKSYLYTDHEKLIVNLEENIKQINKENTKNAQKLEIEKKLVISLNKELEKKNKIIKEMELSLEKLTNENNEFRVQVEKEKIVTDSVFEELEAEKGRCTKLADELEAERGRSAKLDDELEAEKGRNTKLTAELEAEKGRSTKLGGELEAEKGRSSNLADELETEKERNAELTAELEAEKGRSTKLDGELEAEKGRSTKLAGELEAEKGRNTKLTAELEAEKERNTELSDELEAEQERNTKLTAELEAEKERNTELSDELEAEQERNTKLTDDLEAEKERSAKLDDVLEAEKGRSTKLAGELEAEKGRSSNLADELETEKERSAKLDDELEAEKERSTKLADELETEKERNTKLTSELESEKERTTELTDELEAEKDRSIKLADELEEEKEKIIKVADELKTEKEKSGKLGDELEAEKERTTELADELETEMGRNTKLTAELEAEKGRSAKLDDALEAEKGRNTKLTDELEAEKEKIIKVADELKTEKEKSAKLADELEAEKGRNTKLTAELEAEKGISTKLAGELESKNKTMSQNKELEDMNKMKNDNKDKEGQQNVKNTFFSRFLKKYKKNNNNENDSNENGSNENGSNESSSSENKITNKTLNKFKFLNDNEKDEYGNLYYSHIESVIKNDNLEKEYNKMIINFNSRIDNFNKKVEYFDEKIKYYKNICTNYEKKNIYINNCIDKLEELIIDADEKKDNNKIKKYIQKKIENLKNILKELKANYKIEMIETDNMLFDEILKEKDILLKKINNYKINNTDNEKSEELKKYMKDMNFKTINDLFIFHINSIEELNLIKAQFNKMIEDCSIKDKELTIVNENCKSLLLEVDNLKSILNDLFSYKENKSETIDVSENICDKIGSNKVRDKIESNHVQDKIELIDLTEPCKSLLKNKENLTNLKIPIDNNSDIISNINNELLENSNFPLNYSDTSNGKETKRNSYKPKKQRTPKRGNNKLASEAVDEVSPKRYQLRRSSRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVQ8</accession>
    <name>V7PVQ8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVQ8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22934">
        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="3">
        <location>
            <begin position="133"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="395" mass="46855" checksum="CF6689D849E6ABB0" modified="2014-02-19" version="1">MYNEINKLTSVENEYLEKSGKKRRQQNRSFYLISNEHDNDIKNPNQNNIESYYKTDIQENEEDPYTLEVIRQLSSIKIDSSTDSSSEKDVYARSQVGEKKNEKKKKRVIRHIPSVECVEDIVVYDESKDTEFPDLYQLFSEYNIKYFYNRLESVQVKWSNKMKLCAGICIFKKSGYCCIRLSLPLLKLRKIREYKETLLHEMIHAFLFLNQKKSDKNDGHGPEFKKHMYRINKLTGLNISIYHSFHDEVHFYRNHVWRCTGICRKYPPHFGYIKRSMNRPPGPKEKWWRSHSTYCSGKFVKIKELESSKTAGENANKQTPDLNTTLEEEIEPPQKNTGKKIEKKIGKKIGKNNEKNKYANKYANELVPLLIMCICVFEFLKKMMIEPTRPYKLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVS6</accession>
    <name>V7PVS6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB62253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1315" mass="156684" checksum="234CD5EAC39B6FAC" modified="2014-02-19" version="1">MNNSFIDLIKDIKKDDSLKNVERNYNICINNLKDLEKKKQNDKIFSFNNVIKEKSYILLKLLYLQMFGKKIDKEHNFSVIEILTCNKYILKRRAFLFLNNINDNEDVIFLLINLYKKELYKENISNTTIGTKTRVLNSLTNISTSIIKDNLTMLANTYTNYGNNGINSNTGPRNSTSTVKAGSNFVSKENDVSHFQFKKQEKKNAHQNINDNINTKSETIYQSDKKEKKYNSEFVKNNNPINEHTHNDDKNQQNNPMYLKKYLSFIPFIYNILNDRLHLIDNWRLIKIIKFINKLTKYENRIYKKFLSIIIHIFYTNKAQSVVYECFEFILFNYKNSYDLEINLEKYISENEKNLNKQENNAKMNQNIMNRQENNEECYKQIASLNKNEKINKENVYAQNGSDTLLCYCFSHLIKYLYSDDKNIVYVCTKLYRSIFSIPDLYNIFLKYNLMQDFSRHIFNNFEHKDITLRNNLLYIIYFLINKNNFENIIYNILAYIYKNNDQGYLDEYINVILNYGENNLKYLNNINLYIFILFYILCLKNHGTHIKLLDQIHKINSQFSNTFISTIFLSSLFIITYGNFLINTILIRKEIGDDNCLTTNSLENNTAHNLSTLLTNQKNDIEKGLEKGLEKASSINSDNDNNSDSDNDDIICNRSEPKRGVKEKVDKKVDKKVDKKKVGKKKISRDSNIYNLNEIMENEVYYFFNNHNESIEKYDVFEYIINILKIEDKISYRKENTSTYIDINNMNIKCFDYLIYFISIYIQETYKEIKEFKNDHFLNIFFFSLYLFFLKFSTSSILWNVTKIFIFFSQFNQFYDISFFYLYKLEKYIDNLIYNQNDIQNLDRSLILKHILALINSKQTKNTSIFYNYFDTKIEIENTEMSYNYSVPFKYNDSFFLQTNNNQNSDKTSNFQSVNKYHTISKSQTFNDELNILLDKNKRCSNIFKKNKLLFLVHVNNHFKLYYHITQDHILHLYIDSLKDDININNFILSLSANIIEYKTNFEKPKNFKLIDSQENYIFKFTQNYLTEQIQNIDSTQLEDKINNQNICTNKKITKNEIKILDNIIGCLTISIKFSTPFNYIKLIFSYSHNIQSYEIPTIALPYFPMAPFLLSLDGFKKIDKKKGKFRNFIHEINLEREKDVREVVFNYFVFLSEYINMFFFNIKNAHLNLKNNNDTSDLRIILCTKRADKQDGIILLINSRHIKLDHASEKSEKSEKNEKNEKNEKREDNEKNEKSEKNEKSEKNEKSENNEKRDDNEKREDNAAHLVPYQIDIQINLLNSSQKEDELFLDYLNYYLSALFSKTINIDDILSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PW06</accession>
    <name>V7PW06_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PW06"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000205">
        <property type="entry name" value="DnaJ protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="50"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="250" mass="29390" checksum="5C4E01ADAB58CCC0" modified="2014-02-19" version="1">MLKMFLVKKRYASFFNNVYKFTIFNNKLPNERYGSISSLVCNRRFFASRNFYDILNVKKSSSKNEIKQAYRKLALKYHPDRNPNNRTESEQKFREITEAYETLSDDNKKSIYDSQLNNGFSSNSFGNSYSNTSNQNMNYNFKTTKMTDEEIENVFKNVFGNMNIDDIFRSNIFNENHFKTRTMRSNIFSNFESTESHGSANSNIKQTNIKTEIIPRGNKIIEKTTKIIIYKDGNVKQEVIERELNNNRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PW30</accession>
    <name>V7PW30_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="704"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1426" mass="167127" checksum="A10CDD008DD07F75" modified="2014-02-19" version="1">MCIYDEYITQEKAIKGIISKKYIRGIIHIRRLDYGYIDHEEGKIHIESKEDLNRAIDGDAVVIKLKNPNRVNNLVKPDKSIGKVVYIEEHYGSTKQYVCIFRNKVKDKKYNVAIPFKKNIPLIQVQNSHIKEFMKKYNVNDISNQLIYIKIFQWSPTEKFPEGKIVEILGQNDVFHNMQNAILLNHGLNFNLKKALEDQYLKDLKNKNNYINIITDELKKRMDLRKECVFTIDPETARDLDDAINICKINKKIITNSNYYIKIMHNLMCHNGEIDETLLEQNLPLFVNNDQDFFSKLKENEYVKEIENIKFQNFIKEKIVNDTENQQTSEIANYEDDKLTRGIEGIETDLTRDPQIGKYKQLDIERKGFTKFEDCYASKGDEKMLKRKNRENSNKGKKMKKAEKGSKKEAEKRAKKRAEKRAERRSKNMDIESDTDIETIIYDNCKKNKKFINLNHNKFDKIIMDNDCNQIRNITIFNNDSSSNEDSFDDYTHFNKKKKYNNIQEEKHKNINNKEKNIYKEKFERSFLDISSDHEDNNNNNSNESENDDFFDKKNDFDIFVKDGKSDFSYLDNTVNKNWNTNKISTQFNGVKKIENSEFFPNTTNRWNYDTSQSSINDIGMNEENFEIGKINTISKNLKFYNTSMHSKNIECLSNSSNNESNNDGKKGKGKNKYAYIFKQNRNKDIGSELYKDSDNYCPKCKKYITIDDIIQGMNSEQWRKYNLYEVGVHITDVSFFVKENTSLDIDARNRAMTIYLTHTCFPMLSRILSENLCSLDPINNRLCLSVFFYMDNSGKIDHNTFFIKETVIESKVKFTYEEVHSIVSGYVQLKKIINKLKKDEKDAFFLRNANYEQSDKVSQDPIDVRKVGSIVSNFSKIENENRLVKNSSSNDDTNLFYFNEKKKNNLDKKSANCDDNNDKETMKKKDSNNNEKKSNSLYKRFLNLHFYSKKKNSSVVDADADSGSEKDLPVSPSSITNMIVDKNHGNTTNNDSNKQKGLGTFENKGNEMESSSFIFENEKNVKKKNGGIVMRKSDRNKINERVLENDQVKKGIEGIIKIFKNLNNKKHKLSQKEIINITKMLYDMYKITKGARMIRRKNGSLLFNNDKINFVLSNSYSPLGIVKKKNTFANYMIEELMLSANKLVAIRQYFSKYRDVSIFRSHNSSDSLNVSDIIELLKKHGIYLKVNSLAHILQFLDEKENHLKKNKTKKSIFETVCAFVKKKMVRAEYHTYKYIKDNDMSTYHYALSFLLYTHFTSPIRRYPDILVHRIIKRIINDEHQLKEKLCTSQEILSIVETPNVGIVENICENCNKCKARSKKAQMDCEIAFLCLYLQKHETPGYNRGIIMDIQKDRASIFFKSFSFENPLFFTGTEKHHHKISKAHLKYLCNYTIQPNPNKEEFTLTVYNQDAKTIKLRKVYKVLKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PW32</accession>
    <name>V7PW32_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">YYC_00494</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000018">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="16">
        <location>
            <begin position="244"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1016"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1027"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETB62832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1990" mass="229968" checksum="D25BC900E344B1C9" modified="2014-02-19" version="1">MANNIKLDELKTLIHHKSMRKDFVKDVKNNYEIKSINFGIMGKEDIIRYSEVKILNREMYKNNSNGVPYPYGVLDLRLGAHKSNSICETCKKKLINCSGHFGYIELNYPVFHIGYYKYIIHILYCICKTCSHILLPLEKIEFFSNLKKKKNIDDSLFKRQFFKRILSICKKVNKCYNCGSPQGVIKKIIKPSLDQFMKLKHIVKVKENGKQVIKEEDLNSLYVLKLFKNINPFYIKLLNIENPEKLIITTLIVPPNTIRPSVIIDEHGTAEDDLTCILSEIAQLNNTINSQSSNGYQTNQFLGNIEFLQLQVTRFINSDSPAVSQLLATQNISKPGRGICQRLKGKEGRFRCNLSGKRVDFSSRTVISPDPNISIDEVVIPKIIAMRLTYPETVNKYNIEKLKMLIRNGSNVWPGANYVIKKNVNMNYDENGKIGNSIIDIVKRYVNKSRELNTSFSKNINNEQNQNSSNNNLGANRISLKYANKKYVIDHLKIGDIVERHICDGDIVLFNRQPSLHRMSIMCHKARVMDYKTFRFNECVCSPYNADFDGDEMNLHVPQTEESRAEALYLMNVKHNLITPKNGEVIIALTQDFLSASYVITNKDTFLDRDLFCLLCSYFSDAKIDIELPVPAILKPKELWTGKQLISVLIKPNKNENTIINFEMKEREYSTKNGDLKYLSRDDSYVCFYKSELICGSLGKKVLGASKYGLFYYLIHNNSTQIALQIMNRFSKLSSRYFSNKGMTIGIDDVTPSRVLTDKKRDLLLNGYEKVNKEIILYNEKKMQIQPGCTLEETLEIKVKSILDDLRNDAGKTCNQYLPYLNKPLIMFNSGAKGALINIAQMIACVGQQNVSGQRIQNGFINRTLPHFNFHCKGSESRGFVQNSFYTGLNPTEFFFHTMSGREGLVDTAVKTAETGYMQRRLMKALEDLSIHYDYSVRSCDKQIIQFIYGDDALNPSYIDSNHTYMDQFDKIYNHIISISPSHTLFLYKPRKRKQFNLLESSKGVEKGNYVINDSGEKKKKIKKKNNNNNNSDSGSDSGGDGGNSLEPFGSIPFSENVQTNSSFLSKIINKISEKMKEVNKDNILIPLEHDVEFVGKIVGGNGCEINEEGEQTDDQRQDENNIMLSQKNQAILPPNKVKEIAYHLNQYRNIVECVNILKKNSYIKNDINSNSSSSIICLNEMELKYLNNKYNKMSKNIRKKIEIVNNIYKKEKNKINRIKEKLKDDYFYPSMDESIFIKQLMRIVTKENNEMDDITTVGNKDILSKIHLYKEGNNKNNISLNQYIQNNLNLNKNIKNEYIDIFDKINECELLYENKCYKQMIKNVIAFVSVFEIVCDVKQHYILFPYEILRWTNFLLNHVTETIPLNIYSHTNISKKENPTHQKNTKTMKIYIEELKKWLLLKAINIYKFFKYKKGVELIKKNDYYNFVKINDKSNLYDPSYRSMIYDYSFINLKQLYIFIYFNISKYFKYISSPGDAVGSISAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINASSIIQTPILNIPLRIKDNYNFALMMKSKLEKTSIRDICEYIKENYCSKGIYISIKFNEDLIQKLFLNINAYTIRDIILKQTHISKIKINKIYIDVINDYKLHISIKNDEFIFFQIESLKKGLLDLLVYGDKDIKRCIIKKEEIEVTDDELENCDAHLDTHLENHISSPDAVHNENVNNNIVEKKQCIKVENVMDVSNTQLKDNDNYEKLLEKEKVKTEEITVKHHSENNTIFCGGKSKNDEQTIDLSTANLDNLNFDEINVENIINDKIEMYDEEYYDTSNDLKEKNNYYQKKQKKKKKKTQYSILVEGNALNYILGLEGVDFKHIISNHVINVFQVLGIEAARVTIINEIKKCIEAYSIDIDIRHIMLLADIMAFTGEILGINRFGIQKARQSTLMLASFEETNEHLFVSSFFKNNDEINNISESIIVGKNIPIGTGSFELLYDYKQPNEQRNLTLLERAERELKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PW35</accession>
    <name>V7PW35_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_00945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PW35"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB62358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="115" mass="13534" checksum="38B1BADD3173157A" modified="2014-02-19" version="1">MSSLPLRKNHDHMRNDMERNSHARVKISNLEYTINKENLMELFTNVCKVVNVWINYDHTDRSDGTAVCIFESIEDAQKAIDKYDGSEIEGQSIKMEMLHKSNYGYKKKYKSKCPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PW38</accession>
    <name>V7PW38_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PW38"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="327" mass="38853" checksum="193B9D3B381A601B" modified="2014-02-19" version="1">MNEDILKALTNRELKKTILEKAQKVLSERKNIINEKNTNLLNDVETNDKDSIHCCNENYEESELGNKDIISLDDKNNLNPENKNIHFFNLQDFSMRYSKTCKINNLNYENIEYELLVSFMNTFNNKIKFHLKLNNNDMHEDKENSILHKMVKIFSDKLIICCTNPIIMFTQNNDNNSLFDKEIISQVSSFFNQIEECEDFENLFKNCLTTILEKIFNFKPNADDMATWVSRQAFVDLVKIIIEKSAKRNEQCIIYTANIIKKNYTNLGFFQVDNVVVLIEIIQYAIINLSEHKYNEVCHYNIFIFTHIFSYFYSYFYFCVEMHFICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PW42</accession>
    <name>V7PW42_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PW42"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="302" mass="35980" checksum="1FA3C875BEC35B07" modified="2014-02-19" version="1">MNEDILKALTNRELKKTILEKAQKVLSERKNIINEKNTNLLNDVETNDKDSIHCCNENYEESELGNKDIISLDDKNNLNPENKNIHFFNLQDFSMRYSKTCKINNLNYENIEYELLVSFMNTFNNKIKFHLKLNNNDMHEDKENSILHKMVKIFSDKLIICCTNPIIMFTQNNDNNSLFDKEIISQVSSFFNQIEECEDFENLFKNCLTTILEKIFNFKPNADDMATWVSRQAFVDLVKIIIEKSAKRNEQCNIIKRINKCIYFLYGYKYIVILTFYVCINRYNIYSQYNKKKLHKFRIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PW58</accession>
    <name>V7PW58_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1674"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1783"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1683"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1783"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1808"/>
            <end position="1820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1834" mass="214497" checksum="5A89468BF27064A0" modified="2014-02-19" version="1">MISKFYFKTIFKNRNCTQKKKNSILKDSYNSYNSKYYDSQSSSKLVINENSNNVPKHLCHEKNRIKSPLSSNIHDNFYYSDNYFSEKPRKSEKKNNNNRTKQNNKACEVSLKNNNLITGKKNNITLAKNIKNNDQSISKEGITIKNDHTEHRNLLNEDINLNKFDTTKKTCSQGKTVSNLSNGKEDNNNINKSDDNKTDPKCKKLSSPQVCMSNSCNISNYASDKFEDSYIINSQNSSNAYINGDNIDSEQMTPKAENILKKKFNDTNIEKNSQYNNDNTCKENYGTNEKKHINRYNTPINSSRHFSTISNNINNTPLEIYNEYDSNINNIKRNDSYITIGSDNLNDSVFNENQDSFYIPSSVYNNYGSSVVNNRYSVLSKYSNMQNKTSNGFSSPFINRSSNIVCKPRVENCNNNLLNEEDKKNNSMNLFPCQKSIDIKPINCEDKKNQEEIKTNNPKEQIESNVKISNTVKKEINFSELKNLRSSINSIASSNLRKTPTISNIENDNYSIPPKYIPEYIKSFCIFKDNHKKDEVSRITPLIDHVNSNNNDIGLITPKNKFDTSSLNKDIKMNNNDHEFSVDECLMKCLKEDPSKFRTNEDYERFCNEDKILNPSYVPHESRKLGENFLKNKKDNFSFINKNYNYEPNVNIAECGNSSFNYDGGFNDPHKNYFNNIKINVFNNDYVNNDNNCYNNNSIYNNHNINSINNLNYMKGGNDHYNNDIFIKYYEKYSIKNLDKNESEKLNYTDCYDFKDSSLTEISKDDSFCSDDLGNDDNDINCLKESLNSFDNLESTEKKYEQILKDFNGKIPLLHKVLKPLPVKNRSNNFDICLYLLQKHGGDLNNEENICILRDREIVQHSAIYDTKNNCIKSNITNVTNIKLYHPKWYNKKKIIERLKEQSCYNPFTIFGSAPSLLDFDEVFDKDVYNHFVSKNSRKNHSLLRILAKQKVISNLNDKISDKEWPQVHSYLKKRWSRETNIELNWACDPLLYEELEWYLSTNNEYLNMTDKVADIDVCYCPTLDPSSYYAWNDSRVIYTNLCYNKSKDDGEESNNDSKNMYSTNKSLEFKKNDKQLSFRKRASGCEHLMFQQNVMKQKKLSKKKKKLLKKKKKMIKEKYKTMDIDVNFGNYGNDNNREDGKIIKSAEGFSYPYKNMSNYHENKTDYINDQYMNDFKNNKENNSFYYSNNIISKNKKSIYNHKNCEDNIVPIMAVNTSLYRNNMDNKYNCHNTAFDYIKNKDNTIKFFASPKKKKKKSFKKSINSDCFDFINSSMTNSDSMHPTNNNNENSSHNIGNNNNDNGNPDFNCNDTTEFNEFNDFSTYNNNKNNFHIFEFNDSIKCNNMKDAYNKDMMLNEDNLKKKHNQKNYEQTGYIEEMCGNKNRQNDCELLDINENNFEKNNMHYFKSNTYMYDINNNNASGMKNYIAKSNDNIVYKSNYNMNQGDISQSFYKNNGKNNNYGNDNNVKMTMFRNMQMGQNEYNMNYHKGNNNDNNRNGDNCNYRKGDNQMSFIPRNFDDKNDINTYYKVYNASDNNSNHNFHKNIYGNKNIYVKSDSRYVSNDYNKLKGNELSKNEHISNNIGHFEYKSSNKNFPDQNILNQKDNINGLKEKYINMCKEEKQLITSSDHNQFNFFESNYENYNNNNDDNNERSNKIMNEYFHSKNPENYIQMEKKNKKKKQSNDTGNSNNTMENHQNNNKHINKNLRNIIPETNILKLTQENIDKKNIIENEIKNSNTLLYKKKNNNNNAGISTSSFNSKRLSNSNISANENKKIRRYVNKMHHDSDNVSIEHSENDKQRNTSKEIAETPSSATSETSMSSAFKMATSVFKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXS4</accession>
    <name>V7PXS4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXS4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="117" mass="13512" checksum="AFD8AFEB791B3230" modified="2014-02-19" version="1">MKYTAFKNSLRFASKFCQNNNYKLYMNSVPQFSTYAYGKYLKTNPLTNRLDDLLKKNSNLISIISLNGLDDLITQSSKIESVSIADWLLNLVEEYQLMLSCVNMTTIRSWFSIRSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXS8</accession>
    <name>V7PXS8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXS8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="113" mass="13074" checksum="3D13425C30CCB2DA" modified="2014-02-19" version="1">MKYTAFKNSLRFASKFCQNNNYKLYMNSVPQFSTYAYGKYLKTNPLTNRLDDLLKKNSNLISIISLNGLDDLITQSSKIESVSIADWLLNLVEEYQFGFPLGALDSQHYFIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXS9</accession>
    <name>V7PXS9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXS9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="288" mass="33871" checksum="E5CBE2B58E3312A7" modified="2014-02-19" version="1">MLKLIKNYTIFSSILFFVHFLTVNCINSSYYHSRICKIKSINHSKPIIYKIFKSAHFIRVPIKSIPINKKSNKKSNKKSNEKSILSNTEQNDSDLDIELENLMKDIEDGKLGNESLKLYREIEKNAAIKEEQTKQIEEQINQMEQMKSINEHNVEDVINNTDNDLKTCVRKAFYNTGVNENDNMNVKKEYSNINKIEKTFDEIDDINSPNENLNINDIYKKINSMKDDDYKSVPFKDTAKEIMKYKGMLHMPYEMGTLLNNTKFDWRESLDHIELNIPIFDGKKNRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBA5</accession>
    <name>V7PBA5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="6 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">YYC_05711</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Host cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="6 13"/>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PBA5"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000187">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="9" id="KW-1043">Host membrane</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETB56270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="369" mass="39938" checksum="3E7D48CEE83E8E85" modified="2014-02-19" version="1">MVGCVEYKNAPMKLPKEVAQELAETAKKLVAAGKGILAADESTQTIKKRFDNIKIENTVENRASYRDLLFGTKGLGKFISGAILFEETLFQKNEAGVPLVNLLHDEGIIPGIKVDKGLVSIPCTDDEKSTQGLDGLAERCKEYYKAGARFAKWRAVLVIDPAKGKPTDLSIQEVSWGLARYASICQQNKLVPIVEPEILADGAHTIEVCATVTQKVLASVFKALHDNGVLLEGALLKPNMVTAGYDCTEKTKTDDIGFFTVRTLRRTVPPALPGVVFLSGGQSEEDASINLNSINVLGPHPWALTFSYGRALQASVLNTWQGKKENVAKAREVLLQRAEANSLATYGKYKGGAGGSTAGASLYEKKYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBB0</accession>
    <name>V7PBB0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PBB0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="168" mass="20864" checksum="A8B27D40EE7C2484" modified="2014-02-19" version="1">MNDIISKDNQIKSKNFITIYTIRMYLNGFIIGYVFRKEIYKNFYMHKNDNIIFDIIKKNKFSPIYNNYKKSTYISKITLRYKTKNDLFKRLKAYNNNQNYQNYQNYQNYQNTSKTILFHKLPYLKRNFHIPNFFAVRLSFWTCTKNMHTKKFNLYLYEYCYKHMHNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCG9</accession>
    <name>V7PCG9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCG9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01590">
        <property type="entry name" value="yir-bir-cir_Pla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="298" mass="34355" checksum="6AB8221864A15C62" modified="2014-02-19" version="1">MHFLCKKFENVKTNFTYEPNNKNYKIKNDDDFKKYCTNNNCVTEIDKINAGCLYLFDAFFGNSSSFKDLANSNINIVDYIMLWLSYILSLKNNEYKNSLKYFYSASINSDEKYKKAIDYIQGNSNYKDLIVNKHDLTNDDIDSNIIANLYDAFNKLCDIYTEFNENSPNCDKCLTKANEFANKYEALNKDSNNTYGSSYNKILYTLSTDYNKLKDKCSNIPSITEIATNSYAQMSGYASSSSIANKLFIVLSIFGAIAIFLGISYKRKNKKYKEENESLIYYSKSSDYSMNSNNSDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDE9</accession>
    <name>V7PDE9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDE9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF2">
        <property type="entry name" value="FI24008P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="797" mass="88764" checksum="1299E93093300EC2" modified="2014-02-19" version="1">MEHESSKPDKKKNFLNIKLCVLSILILGIQYYNNDKISFNNTEINNNTAIFSFKNDRNLGESRKNRNKLKIKKKYVSDDESEEESDEESEEESEEESDDESEEESDDESDDESEEESDDESEEESDDESDDESDDESDDEKMKKKYKNKKKDSKSYKKMIKENYGGSKPNHPTFPPKSALQKGEISSIPNLPFPIPPMPGMQGMPGMQKMPMPGMQRMPMPGMQGMPMPGMQGMPMPGMQGMPSEDEMKQMLKMLGKAMQQQDQSASDSQQPGISIPGLPFPIPPIPGMPMPSEDEMKEILKMLGQAMPQQDQSPPEESTPEASTSEASTSEASTSEPSTSEASTSEASTSEASTSEASTSESSTPEPSNTDSQQPGMSIPGLPFPIPPIPGMPMPSEDEMKEILKMLEQKLPQEMLQGIPQGKPQEMPQEMPQEIPQGKSQEMPQGKSQGRPRGRQQERPQERPRGRQQERPQERPQERPRGRPQERPRGRPQPNPSMQGMPEMQGMPSEDEMKQMLKMFGKAMQQQGRPMPGMQGMPSEDEMKQMLKMLGKGMQQGRPMPGMQGMPGMPGMQGMPGMPGMPRMPGMQGMPGMPGMPGMPMPGMQGMQGMPMPGMQGMQGMPSEDEMKQMLKMFGKAMQQGQMQGMPPLGDLRQMLKMFGHMMQQGNPGSGHHGRGKKQNMPQMPGISQLLPMMNMLGLPGVNPFSKPSSDTNCDCSDCRKNAKKMSKRKKHKRGGLNMPIVSMITKQALEYIPVMLPLIPTFLLMFSGTRFTYVVLYTLSLIKDAYNFIQSKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDG4</accession>
    <name>V7PDG4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDG4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF155">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="100946" checksum="9D7AFD2BD57A76A9" modified="2014-02-19" version="1">MEINNLKGEKLSNVYLYKNGEIKLIKELENVFIKNICTCSNSINILLKDEDNINKYNNTLIQINNECTNLKNGKSYINISYTNTHTNTHSNDYSNDYSNDYSNDYSTAFINNYVDSDLILYSIHEPNQKKIKVKTKTNTQISINDLKKKLIKTEKNNVWVYCLKKNQLDTKQDKGENEESDVCTKYIPTNCREVYFCCSKFYAINDKNNICQWDIDISNNTNMIKYNYLSKFISYIKFTEKIIDISCGYNHALFLSQNKNCYAIGNNNIYQVSNQKTKYFDTPQLIKINKIKYIAAGHSHNLICTYKNEIYGWGNNMHKQIYLDQNFVKSPKLILNQAIWNSISSRTKKEKTKLREIKKVENWQSGESGENCESGQNEPVKEVKKGDKFEVKKLCCGFSFSCILMKNKNCYVMGVTDFMNNKNGKETKIETFKKINKKKKVDNIFCNFFDIILVEHLKITKVFPPIINPKLDTKIHLFFNFKIKSRHNLRLQLANQSLYNCKNGKQNHKKNQKNHKKRSNEQSDENGDEKINIDFHFNYETDQNGDWEKIKPSPKSQKSQKSQKYDCNRNSQDYSSVQIDKKDRNKKLSIYLIWSNIILNYNKTIYVSEYEGKIKNIFPNNFALMKNLKIKIKINKVPIHINSDCIYVLYEYVDENNKNKIYKIIKGVMNKKRTEIYSKLPILLQNDINFKQDNIYLPTNQNNDTSEKNDTFLKMCSYEKDNHNYIHTFTKCNVYYSFGFNFYKNSFSMLFIKPEILNISPNTVNLHENNIIHINMAYLSKSFKFIYVILYNNNLNFILTKAYYDPYKNNYRFETPLISTTSFKQLQQDSIDFHVFASYNNVEYSENEIKLTVVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDH1</accession>
    <name>V7PDH1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_04904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDH1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB57055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35790" checksum="1F9A85ABE214D6D4" modified="2014-02-19" version="1">MNDLMSFRLHRCWKDQFIKELDLFLKFQCYNIKQTNINDSINDSINDSINDSINDSINDSMNVDPYNTPPNDESMNQNISSNHNEKIKNLKANKCKILDLAGGTGDIAFRILERYKYFLEKIRIFDNKNNYNNISEEFYKNPLINIIVCDVNNDMINVGIEKAKNLNLNKNITWLVENAEELKSIEDNSIDVITLSFGIRNFTNISKALNEMYRVLKPGGRLLCLEFSKLECNVINTFYKFYLNNYIPLLGKYIANNEHAYKYLAESIQTFLTPNELSQLMCQCNFKNISYTTMTFGIVAIHSAYKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEK2</accession>
    <name>V7PEK2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_04984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEK2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB57162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="349" mass="41818" checksum="158539C440FC7274" modified="2014-02-19" version="1">MREILGNYENIIHLNKYKKGEDIFINDYKIVKTIHEGEFSKIIMCDKDGELYALKKYEKMFLEKKREFQKKTKDNKIVIKTKYDDLKNELKIITDIKNEYCLSCKEIITNNDEIYIVNKYMENESILKYDQCFFIFHPNESYFIPIPVIKCIVTNILKSLLYVHTKKNICHRDVKPSNILLDKNGIIKLNDFGDSEYMINKKIKGTRGTYKFMPPEFFVNTKCYYGEKVDIWSLGICIYALFYRVLPFSNKSGLINLFQEIANEEIKYHIDRNYFLSKVRKDATKKISHDSLSNEDINFLKIFLKKKPTERCTIKEALEHKWLRDMNQRDIEEYAKNVYKKKNIFHNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEL4</accession>
    <name>V7PEL4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras-related protein Rab-6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEL4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20196" checksum="3E87BA378C81C179" modified="2014-02-19" version="1">MYDTFDNNYQSTIGIDFLSKTLYLDEGPVRLQLWDTAGQERFRSLIPSYIRDSAAAIVVYDITNRQSFENTTKWIQDILNERGKDVIIVLVGNKTDLADLRKVTYEEGMQKAQEYNTMFHETSAKAGHNIKVLFKKIAAKLPNLENNNNHEANVVDIQLTNDMNNNEKNILSKCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFI5</accession>
    <name>V7PFI5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_04406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFI5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001527">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="337"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB57532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="541" mass="63178" checksum="CD1A10EECFBD48AF" modified="2014-02-19" version="1">MIKIKNRINCTKIAIKFCRTYLEFYKKIFFHIIRLYLYWKIMNINEEKRIPLCCEICIKNEKDISNEIIKVAAHKWLFSLGITITLGRHDPNKIMCEKLSNYCEYIVIEPAVPIKIVKEYNENCENNIYGTLYTTHYSVYETNSHININDNKKDIDNINILNSYEKKNYENIYNDNNLKLKKQNTSNGFNTSNLVSSLATTQSIAYSFPMVNDIKNKDTIKYPSNLLFTVPIIGEKSISSMEEDPIILPNFCCVVNVVTYYKNDDFMEEQFNEPSENEDEEKKNIPIYAQYILPHPRFHKLWDSLYYEENIKRDLLEYVSALMLFASKKIDCNLINYNHLVLLYGPPGTGKTSLCKALANKICIRLSNMYTTGILIELNAHTLFSKWFSESGKQVLKLFNKIKKIINEYEENDVFICLLIDEVESLSADRKKSMDGTEPSDSIRVVNTLLTQIDSLKYYNNTLLLTTSNISEMIDDAFIDRADLKQFIGLPNEECRYEIYKDCIGELIEKGIINYCSKIPSYQRITKLLKNEKEKSKDEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFJ4</accession>
    <name>V7PFJ4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Minichromosome maintenance 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">YYC_03955</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFJ4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000007">
        <property type="entry name" value="DNA helicase MCM8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF47">
        <property type="entry name" value="DNA HELICASE MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="15">
        <location>
            <begin position="536"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETB58336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="994" mass="116131" checksum="6EE864B5BD122D20" modified="2014-02-19" version="1">MHIYKMDKIVQLYFNKLELNDEVKKLILSWVKFFNKNWEYLFSIDKDVILNFEFFLDNKKIINKNAPPNNEIFLHELKKNPEIVLKFMKVAIHLLLYHGLGINEIEDEDQIFKEKNISHKKHKNMRETEKRINDDVENNIFYKENESKIKSFIQNEEVEKVKSNNILLNDLKYDRYKDSEIFRTYFFSTQITIYLYNWNKINKFKNLKSEKVNQLVCLRGSVLRISPIQLLITKIDFICEKCKYIFKIEFIDGKFEIPKKCLIKNCDSKNFAPIRESAKSIEYQKIILKENKKNTSNIYETDNTSNIKNLLVTVEVSKFFVNTCLPGNYVEVLGILKVISHINNYLINGKNSIFNMYIDCISIFSLSSKKYYNNNTFNIQKIKNEKKKIYSTLLWQSYIDNVEKNKSNNLELQNNNNNNNCSTNLTNINEKDLHMNQNYDEINIDDKEYKIDKNKKKNDNFFRNEESIPTLNMYGDFLDMFDINNNYLNNDYINKVANSIDKENESHHNNLANPLIDFDKNTLNFIKDFEKYKNNKFYLLVSSFCPRVVMNYYIKAGLLLSLLGGKTIYDQFGEIKRRGNIHLLLIGDPGLGKSRILQYISNIIEKSLFICSTSTSINGLTASAVKDSTNNEYSLEGGALVLSDKGICCIDELDKISLKDQQSFLECMESQCINISKAGIVCNLKTRCTIIAASNPKEGKYNYNKTIFDNIKIPLPLLSRFDMVFLLADKISEEKDMHISNYLITSTNDTRKNSYLHDQNEKNNFENIRCNDDSTFVEKDDNFDESIFFDFQYNLTNKCKQIDESNYLPIELLGIFIKYCRKSLFPILSNEAKQYIKKFYIHLRNASIAHNNISIPITIRQLESLIRLCQARARADLSNIVTLEHAKEVVVIYQKTIFYPLSLKVMDFKEKKNNKASRGKSAKALSGLFKKDIIKIAQISGNKINNKDLRNLAQSIIQSAESNISDDALIHLVNEEGFILYKGNHWEVDLFYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFK4</accession>
    <name>V7PFK4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFK4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB58346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="193" mass="22912" checksum="35590B5CA8E84CAD" modified="2014-02-19" version="1">MRILLILKLSILFLFVSVNFITMFSYFKKITVMKNELKPSIYDYNVKSLDGTNISMSKYKNKVLIIFNSASKCGLTKNHINQFNELYDKFNHKGLEILGFPTYQFFSQEYKQSCDISQFNQEKKIKYHVFAPIEVNGTNTHELFKYLKFNCDEVSYLYSILLMCVHFKKINNEKYKISKFISFIRTLIKQCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFK5</accession>
    <name>V7PFK5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_04947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFK5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="773"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB57113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="94128" checksum="76C03EE1660D8E4E" modified="2014-02-19" version="1">MFPRVKYRFEKTESSNSEENIDNHQNNKNGKLLEHEHISMKKIRNVLYDEAMNYSEINTYYKSSNIHNYNNMNAYINYIKKSNYTRSYEQENIYNEALLLYNNRNTYIRNAYRNDEYLDIKRNLKKGEYFGDNDEDYLFDETNDTNKISKQKDADADADGYDVGNTDNNEFGKNNLTKKRIEYEHLYKERKKERAMKFAEKYGDLFYDEKDKIINDNGDLNDKQNNHMGYITSGNGHIQKNNKNQASSTNILDDLLELHSMENTGSFCDEKETNFLETLVKLRYTPEQISKLSDLFENPRTLKNVNINLLKWLDMQLNKGYWLERISLFLLGLAISIGVGNIETIWILMTTWHGVVFLLPYVLCYMFVCHPILMFELYSGQLVRNSSPFIFYKLLKPCASIGFVALFLCLLSSYIHTYRTAAEYLIYLINSFKHDLPWKLTQNEIDFCTQIKNDAITCLKHRPLCLFSKSISSCVPNNIGKAFLIYHDKFFPSNDKYTFLLNLNKKKNSINIFSNSDSYIDKDSFVFLLFCNLLATFFQLLGMTNFAFSVALVLLLLGFLSITKFIALFNLSSVMEAYFYILKMWNFSYLYTYSSIWSQCMMYALYEMSIGMGIYSSLATKTRIGSNLAFDGQAIVVGNSVISILVFFSAVAIIGFTSKIMKSTFVEILEFSRKDCSFILFPVGFSNLQRTEKTLCMLYYGSYTILSCATLAIQREVFIISMKDFKFSKNINKRTLVLIFTLLFFVFSFFISTKNSKDIIWFLSFTISDNGRILVALLICIVLGWVYNIEYQYKRLTSRSKLFDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFL1</accession>
    <name>V7PFL1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 5">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_04266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 5"/>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFL1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="7">
        <location>
            <begin position="928"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="805"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="872"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="805"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB58214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1266" mass="150251" checksum="D8B985178B26303F" modified="2014-02-19" version="1">MNLNENKSQNGFNNAIQENDDSMSLVSEGLDGSGNEDYRENEIEDYRNNRKEKYEGNNNANTHESLLKNNKDNIDSKLGFDIRNVLRHAYLPVCIEKMKEGEYVYKWNNNNIFQKKTLKFVYLDTNNYCIRWNSKKKKLKENKSLALYICDIIQILDGSESTFFKKKEEEKSLSIEIISIDRNLRITFLDIQRWKMWLFGLMYYHYKLVNKSSRERKKLKPFIYESNKLYDNYIISGLKDINVLTLSQLYIILRSLNIYINMKILYHYFSIYKNKGTINYYGFTKILEHIFSNNHISIHFNMYKNNDSNYIDKNQFINFLIDIQCEGKSEERIFKIHKKDNYPRLIQDKVEQNEIKKKEDNHAQNWNNNQVYTNQHIIKDKNEHNISENISNDNKISKNNSMIDEITNGYDLDYCEWRNLMKTLDISDNQNEHNLQCNANIELNSFMVSDHSKQYDKDYAMILNILRDKYGVYSTTNYNDKFYMNSHSKSEKKYKREIYTYEENNRKEQTNEISKEDKNKDDFYFIRTNIIYKSLNTIKKYNIPFVIINEGNHYLTQIGLVYFLLSKENSIMCPEYAKVYQNMNLPLCNYWINSSHNSYLGRKQIFSASSIEQYIYILIDGCRCVEFDCYYFNKNIVVYHGLYGYKLTSSILFCDTLIACKMFGFSTSPYPIILSLEIHCKDKHKNLIAKILIYILGNQLYIPKTKDEINNITPNNCRNKFLVKYKHFDNNYTSSFYSIFEGLKNVMYDELGYFSDIINEQEDIDVDEPKEYQIIEKKNEKYNKISIENQNMEPEDRVNNYIEQNNSKNTSYKNNQVQKTNKNSDQNNLCGNENVSQRDRHEVDSNYSSSSSSNCLYENNTIHKTQIDEKYRKNDNCSNNNSGFNNSSVPNNTNTSDAITNCGKNMSETAHMSKEEYKKKQDNEKYKNNILNKCSCLKGYVFRNFQENRTYNEICSISENKFIKLIKKNEDDVIKYNQKTLTRVYPSGTRLASTNFNPLIFWSAGIQFVALNYQYNGLSMLLNKGRFLENGGKHSGYILKPELLRFNKKHDYNVLSLNIQILSLHQINLLFSIKNKYQEKKLKKELFKMDMIQRIQTHKKISNKRKKFKYLQKLEREKKSPLLSDIQSDDSKKKKKISNETLLKKFKDNDNDVNYIHKKFANIEKEYEDMLTEYKSFLLCSTLSHSSSFNSCSSVTTTSNNTTDSNKKVSSKSKKKNFYQAFLELKKANNLFFYLYVTISIHGYNEQKCYFKTEIAKVNFYDINYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGP2</accession>
    <name>V7PGP2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD repeat-containing protein WRAP73</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGP2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="51415" checksum="AAA2FC4E0304D6C1" modified="2014-02-19" version="1">MMKLAKVEYCNLCFFSKNGLFLLYVVDNKIFLMEIENLNINKIYVTSYKIDYIEFSNDNVHFLVLMKDKGCIVVYSFYDDDVIYKIEDYFQKYTHSFFINKYNYICVLKYEQKYISIYDGNKEEMCLLNIKDAKLKKKNYCLNDDETIFACITENNKKNKICLISFPNCIFINTIQCINYEPNCIFFSKTDNIIIHSEKAKLLHMYKIDGELLYVYSYLSQLPCINVLSKSSHKNFLFLGMENEQVKVLSSENLKEVKNLLLEDTVTMDEKLKIYKENISKKNIPNFVLSNTNYDKEGDDNFSFYTNISEGIHGEYKLKSETTKINDTTKNIKTDMTTKIGISFLCVSICGCYLAIVSENYNNVVRIYYSENFSCIVILQHQKKIMNMRWDSILYKPRLLITTNTPYLFVWMPNDSTVIQMPNGFICKEAQMNFDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGP5</accession>
    <name>V7PGP5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-like protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_03773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGP5"/>
    <dbReference type="MEROPS" id="S54.021"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="11"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB58599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="190" mass="21999" checksum="6927D29875B30EB9" modified="2014-02-19" version="1">MYGYIYVNRQGELWRLLFPIFLHANWWHLIINIICILNLGLVIETKYKKKRFLLIYFLSGFIGNTLTIICNPCQLAVGASTSGFGLIGCSIMEIFLAWKNLSKKAQNYYMFNICIFLVFFLFVSFSPTVDFFGHIGGFVCGAFLACHYNKFLGYDIFQECLHYGFASICALIIFYLPLRLFILNMPCEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGQ3</accession>
    <name>V7PGQ3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGQ3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23525:SF1">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23525">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="44877" checksum="7DFA8A07D2DC9EDA" modified="2014-02-19" version="1">MKKWMEEQKWHINIILMFFHHFFDRINYSMRNTFLHDHYIFLKFKKNKIIGLLSIINSSVCLVISPLIGYYCDKHKKNRLKILRFISISYLLVNIIHYMFIRTNNLNLIILITAISKMLQESSHVITESIFIESIEKGKKSIIFTYQKLISTVATMLGPFFCLILFYLYNDKWNITNIFIIFQFSILTILPQTIISFLWKNNTVNTLPKSEEISLIAKQNEKPNLLWLKSNHVPYIVFVSHIITLAGAGMTFKYFSLFLKSEYKVSPILMCVLNILIPLLLTFFTYLSQKLSKSLGRAQVSLFFTTIGFILLCSLLHIQNYQDVLKVHVFRSVFQNCTNSIDKSILYDFIDTNRHTGRWMGIQSLYYLVWSISAYFGKIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PH01</accession>
    <name>V7PH01_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1313"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="805"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB58836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1361" mass="161933" checksum="918F0984943F94B5" modified="2014-02-19" version="1">MTIGLFRFQMDNINEEIDENMSPLEKAMLYGNSNLKCRKILFIKDIIKLLNNIDYTDFQRDIYPLIVKLSDESSEIKYEICNKIGDLCAYILQNNNDGCSDVISLLFPIVEKFIINYENNKNILRYILKSLLILSTHVNIKTRKKQIFPFLIYLICNDAYKQIGFILLIKMCYIFDRDNIVIYKVLIPFIEKHCISNNIECKILISSYFFNICKMLDESNFIKNQIFIFNKLCNDEYDTIKIINIFNCTHLSSIYSKNLFFNFFLPIFNNFLKNNNLYVFYYSLINLLLFLCIFEDINIIHPFYIRKIIFFFNNLFSSHLFTLNYLNEMAKKKTNYIFLDNTDGVYDDSNSAKIWNKDEKRDDTPSYPLNETDMVTDFQNSKSEKNNEHTIQNTISNELKYYDNYLNEDMCKEKQNNLVEIIEKDPTRQICNDEQNLTTGCNIISPINGKGLWVEDNKNPHKNSPMQELPQNKSDKNINNESDERDKLGIGNISCEIESTEESKNCNFSSESEILNKRKMEKVLFSSEISELECSSVQSLSNEIIYDENVCIFINNKLINDLIIKNHHFCSNISQFFKTHGNDYYKNGNCDKYFGRKIINLMEKNSDDLILENKINGETIESEEFEKDEENYFINLNEKDIKYIDNIFNHDDNIDILQIKGCYYSELEIIKNDIIYGKMLLRQKRNMYKINNNNKCDSSDNITYDIDYEDIYAIEGVDTDSLKKLFLFDTPNNVIVSYNINAVYIITLHIPGLILILKEYFFRFFSHVFFFICTYPYYFVRKTIASLFYDILSNLMESPFFKINTDKLYEDRINMKKQKKNLKKNKKIEETAKKKLKEECSDDIKKKENNYDGEDSTEQSNLYTYKENNIKHQDINHIYKKEPPEIVQTFNNDYATYNNMKRIQNNSFLTSDKSCENTEDFINSCIMEKHEDVLEKEENKLCDDTLDMIYSNNSNTNGSHYSLDQDDTKNITTDTIDQIKEDKNDIQLKRVKKNAQGYRKKWSYDKMIKKVQNKINNNLYANDFFINEENENFFFYINFLGKYEMIYIKYIQKFKKYYSDNSPLHFFHFFIYYFLNDSNVLVKKAILKNYDKIIEFFPNNIQKIFIKYLSDVVNFKTLNYSLRKKVSKIVFKILSKINDAKIVRNCLFPIFMRLCKDEAAIIRTYTSNYFYLFIEKGCPRIYNFFKNGGEILPLEDYKKDIILTNLENDELRSFHFISGEEIYILKTVITTFYKSDRFYDRQVFIKICDGIINECPKNLFLLYFLKPFLNLSDDKVHVVRMTWENCVVSQIQKRGYILSIPSVRNCTFTTMHLYLYICSLHIYYIYTIALGFIRQQICKLTSVVSFFPDFFSDFRKTKQFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PH02</accession>
    <name>V7PH02_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="661"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1359" mass="156937" checksum="C2DA0E285AE5F16C" modified="2014-02-19" version="1">MEYIGNIYDKVLSGYVSAHVLKYKSWEEKLIGKEACKNDSDYIKQNLEEILGTFVKNGKFSHSLWEQHKMFIGDEGIYLLGEIITICQIVQFVDSDDIENVKSNDEFKTNLIDELKKRLIIKKKTEILEKKIISNISMCNGDNNFYNNYYDDDIDEDEGDNNSDYENDKNNIDSIASVSNSTKHDSNELDSNNNNNNTKLNDKNAVSNFVEMLCAGKANKYGFCEYDHKFNDKYNLKNIKNECKSSKSIEHSILSFSEDYDHKYVCLLLNNSGIQEVRILRFSKDCINTNKLLDTLKGTVTFLNELRHLFKYFRSQIFFKDKIYGEFCAYIKFHKNDPNFSGTKALNEFFNSLNDNAIKYLFFGLNEDNLNLLEEAISYCPIATFSFFKNIKLLKNMNVNSVRRTWKAVCSLQKLYKNYKKMQEQNFLDDIKYNSDEYNTTSIHQNISNNGRISLSQPPGNRIYYNLNESIYIDALKDKIHSLLHAASSSTSNIFTNSNIIYTSTEYITNPISLVKCDYISKDAFIRIINTYSSIYVNCKNYNFDILVGNSKENKNELFSDYSNNNIEYNEKPFSGSNNCNNNMQNEGNFEMEKKNLRMTNNMLETNNSIEDNNKTLLEGSDKLLTESTYKPSHENKITRDNSMDDLRINMVKLFKTYGGQCRIGKVQGRCEDATFQTDTPPAFGIFDGVGSWSLEGIDASKFSIGLSLACQREAEKMSKNINGYENVSYNTIIRSKLLLKNSLESVKKEYADAYGSSTAIVGILDEYTGKCGISSLGDSVCMILRREFLPGDINFERETYPKFPVESFLYVNSKGRNPSIIRKIIWKTTDQKWENGAPYQLSNLPDRSQWKDLEARGLHSFVKILERVDIEGDSPDMAISPPSEILCMPGDLILLMSDGVCDNLFDEEIEAYCTLAISPEEACELGDPSAYTSAQDIAYSITNIAKRRSGDKLHSKPFLPYPGKYREPNKIYKGNKVDDISCVAIWVVCENEDSVKYIAMNPNEPSILETDKYYSNNYLHHFNKLTDMCTPTKSFIKEKNRIERVNLKHINTKKGETQSTFSNSNSTNMVNPFNASFFDSSETPIKFNDEPKNKNYEDLSDMVLRDADDEEMEENYPDSNDIEFEQIQSFNKKDSKKKQTLLPSQEEEEEQQQLLENDPLYSNTSMDDMIMKTPNNNMLKEKYKDQIFNQDDDFDHTPKQRMLEQNIDEHIDIINNIYIKTPLLHVDKTNKDNSKKNKSPNKCKIKNKIIEKKMMPLMCHETPKKQIQKNDEKENKSTIDENYYYDDDENDDLINKENENIVTNFEDSETQIKTQNSKNSMLKINKKIANTKRKYNFSPGKIDSVSKMNLYSKRSKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PH03</accession>
    <name>V7PH03_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Condensin complex subunit 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1401"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1403"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1457"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1467" mass="173527" checksum="7E17E558C7FDC989" modified="2014-02-19" version="1">MYLFFKEEDIGVLKNIFMLLYESIDYLDISNLVNINSKNCIFELIKFYIELLKYPLIHSVHILCINYLIKIVIKCYDIRFEYNINVELYDIGPHVNIFVKIVNLIFAKILSILKDIKNSENVYYIEEINNINNLIALLFTNILNSCIRIIIPQVLYNDKQKQKYLLNNEMTRTTKINKIKDDELDAEDKIVLNACNPVFSFIEIFIINNSDKYEKTVFTDLIKIIINNCRKIEKKYNVMKIIHDEFMLHIKGEDNKKNGDKYLDKNYLKTKKISKKRLESTASFKISDECNSSVYSETEGEDEEEEEDEEKGREDGKSEMGDNQTNGYESEKETNKYCPVSKIKNKTKSTLEIDNKKYCIVYESVMIRYLNLLLKYMNCEKHQIRNMILDLFLILLKKKKTNKNENIYEKLFRLFLERLEDPNIVVKSKALSILVTLTNKKHHNNNLVRNFIYNKRKEKINMYKIISSNIFSHRSNIRKLTIQYIEVIFETLISQKLNYKIFLIFISNYLYSLSFDSILSVRRQVLLTVNILFLMASNDEYIGKLWITIILSAITDTEETIKDEAISIFINTFMKASINCSMFNTNEKKINQVLEENGMTYFKALTTFSHELKTKKDDYKNTKSDVEVNPIVKNGSITDSVTSDTNQRKYSNNIIKNKEGLEKEREECDKNNDGVILLIEIWEKYFESNMDNYFLTLLKMMTKYDLLNFNLILLCLTQKKNNVLEEFIKGINIFIYNLRYFSIRTWNTFIFDFIIELSKEYQNSINFESILFLLSRCYKIYLMNEKKNINKSNIIDKNIMAEKKIENIKENPEINNTIKTEFLFDSILTDQELANEKKSCPNGILKNIMLKLFTIISNLLNNENNEVNENFLEIIENTIFNFNCPMCFIYIILNILIKKKKNVNQFIDKLKNKIHFFFEKIEIIPYNNVFCNILVTFIFLINHYKKQDTEFLTMASEKLKIVYENVCKDKSAGSNETAIGGEDSDNLNHLGENIIMVKNCIYMAQCVLIIDKDMMNKSDFFLTLEKDLKNSNTCMNILNNLIILTYYMIKNFGSSCNKFVFNLLRFFKHENSFIRYLSFYMLSKLISEDYVKFNNQFFFGFLYLLADKNEIIRKQSLSVFKHIVLIYNKSNLINYMIDFIFVLNNFYSIKLSKHLIHIGNHFEIKNPEDRYKIYCLLIENLTNSEKFSFQQKLINEYLIQYVYDYDNYYFSDEHAKEKKGDDGINTRAKHNNIIPINDEGNEGSVLKDVLLILSSRLMKIKIKKDFAKLEEKNKNIKIKNVESSVKVLNDLMKNILKKNTLPILLSLRAIMLKTKSFFFKYINNLIIYLCIDYKDSLEELILEAHTRNEIFSDIQHFVYTDVIHSVHNNNDIFNKNSNINIDINFLELSQNQMIEHNLEKNMHNKNIRKKGNIHKKKNDDNSDDTSDNSDRSSDYEEVSNVLHSIHNRHQLSNNIKINKKTKKNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PH07</accession>
    <name>V7PH07_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PH07"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="778"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="819"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB58841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1248" mass="148276" checksum="165E43248892A41F" modified="2014-02-19" version="1">MANQINGIFSKLADMTIGLFRFQMDNINEEIDENMSPLEKAMLYGNSNLKCRKILFIKDIIKLLNNIDYTDFQRDIYPLIVKLSDESSEIKYEICNKIGDLCAYILQNNNDGCSDVISLLFPIVEKFIINYENNKNILRYILKSLLILSTHVNIKTRKKQIFPFLIYLICNDAYKQIGFILLIKMCYIFDRDNIVIYKVLIPFIEKHCISNNIECKILISSYFFNICKMLDESNFIKNQIFIFNKLCNDEYDTIKIINIFNCTHLSSIYSKNLFFNFFLPIFNNFLKNNNLYVFYYSLINLLLFLCIFEDINIIHPFYIRKIIFFFNNLFSSHLFTLNYLNEMAKKKTNYIFLDNTDGVYDDSNSAKIWNKDEKRDDTPSYPLNETDMVTDFQNSKSEKNNEHTIQNTISNELKYYDNYLNEDMCKEKQNNLVEIIEKDPTRQICNDEQNLTTGCNIISPINGKGLWVEDNKNPHKNSPMQELPQNKSDKNINNESDERDKLGIGNISCEIESTEESKNCNFSSESEILNKRKMEKVLFSSEISELECSSVQSLSNEIIYDENVCIFINNKLINDLIIKNHHFCSNISQFFKTHGNDYYKNGNCDKYFGRKIINLMEKNSDDLILENKINGETIESEEFEKDEENYFINLNEKDIKYIDNIFNHDDNIDILQIKGCYYSELEIIKNDIIYGKMLLRQKRNMYKINNNNKCDSSDNITYDIDYEDIYAIEGVDTDSLKKLFLFDTPNNVIVSYNINAVYIITLHIPGLILILKEYFFRFFSHVFFFICTYPYYFVRKTIASLFYDILSNLMESPFFKINTDKLYEDRINMKKQKKNLKKNKKIEETAKKKLKEECSDDIKKKENNYDGEDSTEQSNLYTYKENNIKHQDINHIYKKEPPEIVQTFNNDYATYNNMKRIQNNSFLTSDKSCENTEDFINSCIMEKHEDVLEKEENKLCDDTLDMIYSNNSNTNGSHYSLDQDDTKNITTDTIDQIKEDKNDIQLKRVKKNAQGYRKKWSYDKMIKKVQNKINNNLYANDFFINEENENFFFYINFLGKYEMIYIKYIQKFKKYYSDNSPLHFFHFFIYYFLNDSNVLVKKAILKNYDKIIEFFPNNIQKIFIKYLSDVVNFKTLNYSLRKKVSKIVFKILSKINDAKIVRNCLFPIFMRLCKDEAAIIRTYTSNYFYLFIEKGCPRIYNFFKNGGEILPLEDYKKDIILTNLENDELRSFHFISGEEIYILKTVITTFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PH13</accession>
    <name>V7PH13_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PQ-loop repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_04446</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PH13"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB57593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="25402" checksum="410B72A9B4799198" modified="2014-02-19" version="1">MKPPYFNVWSENFYHKENILSVLNSILVHSIIIGAFFIKIPQIIKIFVSKNASGISFVSIYLDIFVASSLIVLSIRDNINLKLYLDTLLILAQNLLILYFMWKYSNPYSKFIKIFKICLYIFYILFLIYGLPKAFLPFIGIISIPIGIFSKFPQIRLNKKNKHTGSLSPMTYLFLFLGNLSRMFVIFYNIKNKIYMVSYKRKEMKRIKKRIDMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PH19</accession>
    <name>V7PH19_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PH19"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF24">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="417" mass="49384" checksum="0D84CBA47D465C4E" modified="2014-02-19" version="1">MSKVYQRKKVFVFLFLLLYISNWCNHILLQYKDSYIIEYNEKGKYMYLILFWLVEYINGSNKILERKPFSFFVSSKVVYGLYNNKNYSKFSDFCFIKKNNEKKGSVILSSAYSPTTKLLILDKTDDEIYNYTENKNGKKCEDLEKEALFVYRFSDMPQEYINKNYVFYNKDIDNQLENKLLNFIILHCDTKFKNAFKIEFVNNDNFLRNHFSCEEQGLIEISMLLFVILSVLSLIYFRKRNMLSKENGTLKESVHSGALFFYFSNIFYLIHIYAYALNGAGFSVLKVLSQIYESIFDCIILTILFYLINSIHNKKKRKEDTIKTGFIYSMLKFVYILFEIQNHQTLNAYSSLHSVVAFPFVSHRVVISVLIYNNCRKLLKEKTNIADKTNALLDASIYIAWILSIPFIYFFLWNASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PH35</accession>
    <name>V7PH35_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PH35"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="181" mass="21757" checksum="77658397A9781263" modified="2014-02-19" version="1">MSIILRINMCELKPTNSNELQIEFVDEENISNNEKGGNKKKLKEILKRVYIGIYEDSKNILLLKNTGITHILIIRSSKENNIARIMFPHDFEYYIIDIKEDFDFTVYSHFKCLLDDILFENKNNKLFIHRYQCTYMHTQFHTLFHTLIHTMLHTLLQCFYFNNSPSFLHYTHTHTLYFIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHM5</accession>
    <name>V7PHM5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4460 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHM5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028031">
        <property type="entry name" value="DUF4460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027986">
        <property type="entry name" value="TCAIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596:SF1">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14687">
        <property type="entry name" value="DUF4460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4460" evidence="1">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="374" mass="45064" checksum="E19FAB4991D9EB2F" modified="2014-02-19" version="1">MFAKFMFYLKPSNKYVSNYKYLFQHINKQNYESNIFKKSVRRMLLFFYKQVHPDLSQDLPEELKKINSESLSILNSYIDILSSSDKNENNIFVEKKLIFFKLFENSEHKIIKGRYKNIEINLQTINNNLSEEDKEHIIAKLIYDIKNSLEKIQSKNIFNNNDDSMEDIENIIDDTSSYFHHKKKKNEKDDTIKSIWDDLMDHVKNKEALYHPSEEETKYIQEKKNYFYYIKKKLEYKYQKINHRKRRKEKLQNVNKIANKIVQDKFADIEKKKKNIKTNDEQLFLNQSYKITQMGYDPNLIFFNKDINNDKKKKAIENICGINLNDDADKWLLENCLKLLKNHKIQIPIVFYNGKEISLSQTFGYIYVLKCFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHN7</accession>
    <name>V7PHN7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHN7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="6">
        <location>
            <begin position="903"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="709"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB59061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1044" mass="120149" checksum="8A2C1EC9B19762F6" modified="2014-02-19" version="1">MWGKIVSSVSNALDFNQATLSGCIDIICIESEIESEIKNDKKINLIYKSTPFHVRFGKTKLLRSKEKIVNILVNGKTTNLHMKLGSAGEAYFVEKTYDDVEEDLETSPLSSPRYQYDDIFLENNIDSCSIYESSVNNFKSDKEEYEFYANEDENKLLLNNSQNKNTDISDKHNPYDQLPKNKSKSILERKVNSDNELIPRTCTRNRRSSKASYKNDNIKSHKKKSETKIDLKHSDKLSIKERHTTSQENTEKKKKSIISNNDEQDTNEDGDILYNLKTYQTIKKKTEKKTEKNEKKGEKTEKNEKKGEKTEKKGEKSDLKQSPNEYDDKNNNSEWSWSWGRLPHLKIPNQASDNGSIILSSSKKKKKNRSVAPNNKFNTDNNKNKELKNEHLLSIPNDLNVRKRNFSECYIKKSNDHNIDIKKYSLAYINKEKNINFIAKDSKSKNIINDAFAAASKNNNMEKNMEKNSIIHNNPPNNLEPQRTSQSKSTRPLSPNYNTKRSGEKKESNLNLHPTGPPTVPPTDSTKNMFESKVIKKKEEKKQSNDNGPISDDYIDEEENKSNFENNYYDHSIDDTQEHVFDDDIQNRIECSLCGHLLLNQNIDNEHNEYNIEIYNKNIFEANIVTYDQIDRNSNLWYHPSLVFRFDKKDPYYPSRVALPLLASWIVFNQPLSIVAVEKLLNSSLNLIEMKDKSWRNWFGVSNVENNNQIKSKNSKNEKQNSTLTHKKNDKKKNIPNSENNTNNIPLEKDTPHVTSASQSNREHKGNNNVKNGGQNSGQNSVKNSGEQNSVLDIVPNSHNAINLRNSSISHETNFFNFNKSNIKRSVQESLYSKNDDSKRSIRHKDDKIKIRYRKSLRPTSEQLQSLNLKEGANTITFLVTSSLQGTKSINGTIYLWKKNAKIVISDVDGTITRSNVLGHIMPIVGKDWSHDGVSQLFNKINNNGYHILYLTARAIGQADSTREYLFRFKRNDNKLPDGPLILSPDRLFPSFKREVIDKKPYIFKIAALRDIRNLFPLNHNPFYAAFGNTESVIILNIPIVNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHN9</accession>
    <name>V7PHN9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHN9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="566"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1264" mass="146085" checksum="1FBFE7C8F0ADE813" modified="2014-02-19" version="1">MEYIGNIYDKVLSGYVSAHVLKYKSWEEKLIGKEACKNDSDYIKQNLEEILGTFVKNGKFSHSLWEQHKMFIGDEGIYLLGEIITICQIVQFVDSDDIENVKSNDEFKTNLIDELKKRLIIKKKTEILEKKIISNISMCNGDNNFYNNYYDDDIDEDEGDNNSDYENDKNNIDSIASVSNSTKHDSNELDSNNNNNNTKLNDKNAVSNFVEMLCAGKANKYGFCEYDHKFNDKYNLKNIKNECKSSKSIEHSILSFSEDYDHKYVCLLLNNSGIQEVRILRFSKDCINTNKLLDTLKGTVTFLNELRHLFKYFRSQIFFKDKIYGEFCAYIKFHKNDPNFSGTKALNEFFNSLNDNAIKYLFFGLNEDNLNLLEEAISYCPIATFSFFKNIKLLKNMNVNSVRRTWKAVCSLQKLYKNYKKMQEQNFLDDIKYNSDEYNTTSIHQNISNNGRISLSQPPGNSKENKNELFSDYSNNNIEYNEKPFSGSNNYEGNFEMEKKNLRMTNNMLETNNSIEDNNKTLLEGSDKLLTESTYKPSHENKITRDNSMDDLRINMVKLFKTYGGQCRIGKVQGRCEDATFQTDTPPAFGIFDGVGSWSLEGIDASKFSIGLSLACQREAEKMSKNINGYENVSYNTIIRSKLLLKNSLESVKKEYADAYGSSTAIVGILDEYTGKCGISSLGDSVCMILRREFLPGDINFERETYPKFPVESFLYVNSKGRNPSIIRKIIWKTTDQKWENGAPYQLSNLPDRSQWKDLEARGLHSFVKILERVDIEGDSPDMAISPPSEILCMPGDLILLMSDGVCDNLFDEEIEAYCTLAISPEEACELGDPSAYTSAQDIAYSITNIAKRRSGDKLHSKPFLPYPGKYREPNKIYKGNKVDDISCVAIWVVCENEDSVKYIAMNPNEPSILETDKYYSNNYLHHFNKLTDMCTPTKSFIKEKNRIERVNLKHINTKKGETQSTFSNSNSTNMVNPFNASFFDSSETPIKFNDEPKNKNYEDLSDMVLRDADDEEMEENYPDSNDIEFEQIQSFNKKDSKKKQTLLPSQEEEEEQQQLLENDPLYSNTSMDDMIMKTPNNNMLKEKYKDQIFNQDDDFDHTPKQRMLEQNIDEHIDIINNIYIKTPLLHVDKTNKDNSKKNKSPNKCKIKNKIIEKKMMPLMCHETPKKQIQKNDEKENKSTIDENYYYDDDENDDLINKENENIVTNFEDSETQIKTQNSKNSMLKINKKIANTKRKYNFSPGKIDSVSKMNLYSKRSKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHP1</accession>
    <name>V7PHP1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_03702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHP1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF174">
        <property type="entry name" value="GH06923P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="38"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB58954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="34963" checksum="C9430AA0EB323FAD" modified="2014-02-19" version="1">MINIQPPCLPNFDIIRHKSFSNISNIEENINWKIEIKEKEEYKKIFKKLDINNEEKIEGNVIREYYLNTSNISICELMQIWNISDYDNDGYLTFNQFCVMNKIVEVRKIKEINIPLSIPKKLFNSINPDHNLVINGDDTSLNHMNKEIETHASDKSPCLNLLKPENDENVENDENVENVENDENVENVENSDNSDNSDNSDNEKLNMEFDFFEFKNEESDNSEYEKRKKKKEKKNVTKSNMVFKDKCEKFSDFRKEEEREQKDIIQQVSNHDNENLIINKKKKKKKKKKSKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHP2</accession>
    <name>V7PHP2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHP2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="184" mass="22093" checksum="13EDBE88CB40A3F1" modified="2014-02-19" version="1">MNKCNSIFSLKNEFLDKHFFCLFWKNNFHTSPICKNRKSSTFLINFNKKNIAVCEQNEKNNDNAENTALSEEIKRETNSIQHVFKWGIGNKFRSDPENRFHPVHLLRPKEVTIKKSYFDSTNENIKYEDLNEQWEVFWFENNKLNAKPFPIKKYGIEAAKKEAFKFYETLQVKTYYISLLIKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHP4</accession>
    <name>V7PHP4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_03353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHP4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF119">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="429"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB59066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="613" mass="73348" checksum="4F456357344BCF1D" modified="2014-02-19" version="1">MQDDNESIDGNILEKQYEIIKCAKNHDFIKFQILIQPYILNNDIEMLNAINIMHWACYSGFTELVQKLIALNCDIEKEDLVNSDTPIYYAIKNSNYEIVLLLIKHYGSSILFHKNRRQMSPFLTAISEFNEDKILEALHILEFLYLNGISLEEQNEYGQTALFLGVKKNNISILQWLLSKNVNINHVDFYGNTILHIAVRYTDIDILRLLCDYGCLNLVYYSTFENNNTNVFQLCINNRYFLVYILLKKWLIQNKICKGLKICKTIYAFYFWFFALLNLFVYINITQSFLEIKKYHNKSVIWISLWLFQQLLWCILYFKNPGFYKENKFLTNRNKNNSNYMYATDFKNQAEYQLNNIEKEIFQINKKLLQTNNILNPIHNANQNENEILEYNDKIINLKYSKLSLYSQVSQERINSLDVNYRNAILYNQNPRNVCVTCNIIKPPRVHHCADCFHCIVHQDHHCVWVDNCIGINNQRSFYMFILSAFILLLFNYYYVFLYFKLFHNTINYAFALLVILCNFINITLFAFITYLFARNTKTILTNVTFYEHFKRPTHITDKYNTELECWEFQNLNFKKIIKNIYNFWTLNYDEPYLKYDRKIENGIYYALVPDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI05</accession>
    <name>V7PI05_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD repeat-containing protein WRAP73</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PI05"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="50252" checksum="E86CB454FFEAD774" modified="2014-02-19" version="1">MMKLAKVEYCNLCFFSKNGLFLLYVVDNKIFLMEIENLNINKIYVTSYKIDYIEFSNDNVHFLVLMKDKGCIVVYSFYDDDVIYKIEDYFQKYTHSFFINKYNYICVLKYEQKYISIYDGNKEEMCLLNIKDAKLKKKNYCLNDDETIFACITENNKKNKICLISFPNCIFINTIQCINYEPNCIFFSKTDNIIIHSEKAKLLHMYKIDGELLYVYSYLSQLPCINVLSKSSHKNFLFLGMENEQVKVLSSENLKEVKNLLLEDTVTMDEKLKIYKENISKKNIPNFVLSNTNYDKEGDDNFSFYTNISEGIHGEYKLKSETTKINDTTKNIKTDMTTKIGISFLCVSICGCYLAIVSENYNNVVRIYYSENFSCIVILQHQKKIMNMRWDSILYKPRLLITTNTPYLFVWMPNDSTVIQMPNGIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI14</accession>
    <name>V7PI14_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PI14"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23525:SF1">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23525">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="43357" checksum="9465C68BCCDFF3A9" modified="2014-02-19" version="1">MKKWMEEQKWHINIILMFFHHFFDRINYSMRNTFLHDHYIFLKFKKNKIIGLLSIINSSVCLVISPLIGYYCDKHKKNRLKILRFISISYLLVNIIHYMFIRTNNLNLIILITAISKMLQESSHVITESIFIESIEKGKKSIIFTYQKLISTVATMLGPFFCLILFYLYNDKWNITNIFIIFQFSILTILPQTIISFLWKNNTVNTLPKSEEISLIAKQNEKPNLLWLKSNHVPYIVFVSHIITLAGAGMTFKYFSLFLKSEYKVSPILMCVLNILIPLLLTFFTYLSQKLSKSLGRAQVSLFFTTIGFILLCSLLHIQNYQDVLKVHVFRSVFQNCTNSIDKSILYDFIDTNRHTGLFNRLDYSTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI16</accession>
    <name>V7PI16_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PI16"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="99" mass="12237" checksum="96B8ECB9073E39BF" modified="2014-02-19" version="1">MIGNFKKYISYVSSFLQFFLYSGMFYYGTYYLYRYLKISYFDTMHVSNESRRRFMEKQMLFYNDTGYNLSMKYIGNLCKYYDPVALRMPFQPLDDTYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIS6</accession>
    <name>V7PIS6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIS6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="418" mass="48964" checksum="E41176CA78CF4537" modified="2014-02-19" version="1">MHEEECEHRLINCSSCSNLFHYKNIVFVLSLKEKYELNIRNPYTYYSYYYNLLLNTNFNFFNYNYCINKNIHSNNYISRKIQIFKKLQYNLDHHLFSVNNKNNISLPINRNIPLNVCNHDIYDRTNNNNHTNNYDNNTGEHKIVGVENNINANNNSSNLHQGESNIPNTKFTSNRNTHTSVNNNANNFSLTTFLRNHADLESNIANGIGEANIEIVTNFGDSIGIRGFTDINCFNDDHHNYIDNTNFIRDYSDVERIGEKIYLCGEYYMREKNRHLEKSISNCSSEDSSNEESSAEEYLDILPLRKTYNFNEKNSKDTLIIIKELFQFDNINLGNIYVDNKDIFLCNKNCFINTIKNLKDELDKSLTLLYVSCCIGMPIMFSLGYMSFLTTKGFFKLSFLITTTFINFSRRIFNNLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIS9</accession>
    <name>V7PIS9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COPI associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIS9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="26292" checksum="34CF76E294F43C4F" modified="2014-02-19" version="1">MKLNVRYQTLFFSSGVMTVFCGAISLLESMRYFYFTNFIVSTFLIVMGLIMMILDIPGTPRWAAKHRIMIRKYIKFLTRLTGKAVWFFFLGAMSCLNLWPHSKKITFFRSFWVILSSSFILAVAVVGFLIALRKSLRLEKLKKTIKLVSKGAYIDCYRKYSVADPDHGMQFEEFNRMCSDHTNGYIFFDFLDLFIIFNALDEHQKCSINEREFLEWINGPVTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIT1</accession>
    <name>V7PIT1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIT1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="526" mass="61803" checksum="C318988A428B49A3" modified="2014-02-19" version="1">MSYLLDDKKLVLKNLISKNEAIKRENIHIELENKAFLCLIEKYGEKKKILKVIEYIHYVCTMLYKNEEDLNFINNDDNFLKTLEKLINNSILRPKIICKNILETNKDPLLDNSVALDSHHHFEKTTIQPGQEKGQPDQEKGHAKNPIYDVNINDIISLKSKINNHAENAENVDNAENDENDENVDNDENVDKLSKDSKENIKDVDSLNRDKENEVETKEDIYLRKEKNICLHWSEESSTDNFVYSEERDISPKNNITELNLMGKQQLIFNEIEKIKSEIKELTLYLENTKIIVNSVICQCKIFLFDINDEIKNYKNMKENIKKNNFLLKKLNTINEFYNNIMNKQKKKIEESQKTNNTLINLYKKKFINIKYILSNNKDINTVDFLYLHVLIRNKKINYDHLMRTHENDYAHLRKLINDINAIDNELSENEKKEKEILANLEKNNAILTEMDLLIISLTNKINKINKSSNKINNYEHIDAAGNFSVIGFINLNKEILSVEKKIKCYQRKIENIKNVESSYKGKDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIT5</accession>
    <name>V7PIT5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIT5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1141" mass="141125" checksum="F0AD45F95B16D8D7" modified="2014-02-19" version="1">MENLYDLNNIHKEYDLQKKIIELRKAFINIYNFKTFYGEMLKLKNSYPRDINKKIDKLWIEYKKEYFIKQYKDGIIFYELNKNLCFLEKEIINRYLFNFNICNSNYIVQEEDVYLYFVFYRFCSMCINNWERKNVIKKGDKKKKIYKGQNFLNNFWIDKFLKIIIKIDPNYYKKNIYFQSIKDELKKYISSENCLMKIQYKNQRVEKPHNYYFVCISNSCKKREIEKDRNISNYKNWRQYYYKVKYHTHNNMSINRVINKKVNSNILIYNNYKKKNLIIDVEKTKRLIQKYIYNDLYFNVIHSIYHSLINKNADLITDYVYKEILLDIENLKNEEEKYDYSKASYLLIIDKLKKYEHVQKKNRHDLYNENIMDNFLVVFKAFFIPFFTYEKYVNNKIKSNDIFLFNYIKCILRENIENMFYLTIVNINKIYEHMTFKYLFYLFFLYFIMLDISPCFCISHIIFNDKLRGNEKQIYKYFLIKYRKKNEEKKEKKNEEKKEKKKEKKKEKKNEKKNEKNEKKICPEKKLCRDPPNNDYNEMVDKPIYIVCFFCSYNLLKNDKNIDLEMKKKMLILLVMNIVQVHYTQTDNEIKIMKEMDLLNIKKRQFSFLCSYFDIFINYLFFSEKCNLSFAKLGNVKRCYTYTKTHSCYFIKNKNKIKNNFKQNLKKMNKKCVYLAYFNKAINMKDEKIINNYTEETKIDGAIYTSENNLYEHVNEKIKIFLENFKTFLFYFLDKLYRTSIMHINLYTYLFMIRSSLLLSCKNYENTRDIQKIKEEKIFKYNRKITNIRKRKRYRGRIKFLNTFYRKIYLHTYYKLLNIICNDEEKKKILQKFKIKINKLLLYLKKNIFTYNIHNLQILFKLQNIINVYKHNYIKKKYISLSKKNIINNIDDVEKESCYIIYSRIKLFATLYFFFFKKRINISLENRQNKIDRECWHNLIANRNIINNKNDCILEKYINIVYKNINILFPNIYIHINNNDFYIQAKKDFIFFNLKNKDKDNNLWKENIYYEFHGKKYIVFENMYNLKKVYKIKYINLCILFHRYCFFFYNYNPFIFSYLFKHIYCMCIECVQKYLIIDNCCIKKDKITEKNNHDCFYKQNGILIKNRNHMFVQNFYYLTLFLLIRYHTLLGNARHSGLQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIT9</accession>
    <name>V7PIT9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1468"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1468"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1557" mass="178097" checksum="D348D9E4AF1F5865" modified="2014-02-19" version="1">MNEIKIKSSIKLQNNDIHDIVATVNLNDDKFAKKILNKKKELKNDDNDDGDFTNNLYSILKRDNKLFDKFLQNKNFCLKIKGKAKKRIGNNVLNGHNDIFDNKTTVGQNININNEFKRYISSDLKNYKGVKFYGKIKKVKNRTKHLLKHSQNCTTQDDSSSYLKKKSNYELIEECNKKINNGHSKSGHIKNGHIKNGHIKNGHIKGGTPIINLSSFIRIKKRIIKKKKKNIKKCKKNKLIANFRETKKDKVLRTKWSGNKKINERKESGIIYNLDGKKKSEIIYNLDGKKESGSGSVYNLEGKKESGGGSGSGSVYNLKEAKPIKNKKETERLSKRNKCPISIRLNYEKNKLYFNCLFKNIQNRDRKQVSNDMNMLDDKTIGSKSICEIDEFIKNNKYVMKENIKNIYKKKKDSDLYSCNNSNYSRKNNNYQNKRNSCHKYDETFMSLSESGESGKNGSLYKDVNFAYPFQNGEEDEKKYINVMGRYGNIKRSSLVSDKNKFEIKRNSEKVPNKTSLHLDNTDLEKQKKMMKNMMKNMMKKMVKKMEKDANQNVSIFLKHPLISKEQISTNKDVDTDHIKKKNVKSLKCNVKRDSLTSIHSGFSQNKSVNEISDDFKYYSNYNFEKKKKLPFLNKSYTNTIFKTEDYKIEDWKIEKKTQSLSVANILDDNKIKHNSLNSDKKLLTLNMSNILDKKKKKNFPNSKFSNSFIGSRNRSGPTISKRNSNKTNKYNENNQIPINDNVTEIKTINGNMDNNNPSFKKLNINSKLILGSKIAEVRSGEKGGEVKNDEVKNDEVKDGEKGGEVRSGEKGGEVKNDEAKDGEKNDKQNDEMVIKFVPKVCKPASKGVVKNLVKKYEHKNGVKQNVNELKKEEKEGKEEKGEKEEKGEKEEKEEKEEKEGKEGKDVNDNDATIGGKEKSGHNDEAKNGEVKNGEVKDGEKNGEVKNGEAKKVKDGEKNGEVKDGEKNEEVKNDVKNDGKNDVKNGEKNDEKNVVAKNSINKVLVKKMMPKIPSLNKSMVKKSVILKTGKKETHDNEQDDKDSKKSEENDSESNSNKNGKNGKNEMVLNKTKSEINEVALNKTETAKCDDKEKVKVHKEISLNKNVKNIPSLKDLKKEKDKNILIKTDNNTNERKFIEKAVKKNIEKMLEKEEIEKDEESEKTWDPTDLSLFNTSETISKIMNLKLFSSVQENINDNIEKSFALNSSEKTAVANAEKEEEKEEEKKEEKDEKKDEEKDEKKDEKKDEKKDEKKDEKKDEKKDEEKEEEKEKESGEPHLDKTANTSSKNQEQSTSKIVSKIGISKKFAFKFPLKASKHCVSKGSVEAAKKAEEKVEAVEKVEAAEKVEVAEKVEENKDEEKNEKDDFVTKKPNILKHPLKAKMPGLPKNNVEKALIKKNNFIKKLNNIKNVLPSKELPIKNVKIDENVKIDENKTNDDNKNGDIRLNPDSIKTDNTSVLTSSINLDTANCHTNNSAEPTNSVNKHEEEIKNESNNEEKKINENINHIPSKPIIKIVPKFPKNVISGPIKTNFTKDIDSLKKAVKTKPPMLSKYKPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIU5</accession>
    <name>V7PIU5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIU5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004765274" evidence="2">
        <location>
            <begin position="19"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="368" mass="42818" checksum="E36B7919C7B2E619" modified="2014-02-19" version="1">MKILYLIILCCITSFRHFQFCSNNNVVENNKTPQILRKRPRKNNKNDLTNVIDFSFINTNSEGNKSEHPENEKNKNNEHVENKENPKVKDNHDQEKNDDKGKKDKKTDKKKDMEDDDFDIEDFDDDDDDDDEIDEKKSKTKGNNDKNKKIEEKKNDEKKKDDKKKDDNKKDAKKKDKDDDDDDDDNLDDEGDDDDDDDDDQEDKPSKKNKGNNTKDEKSNNKHTENLKAEKKTDKEIKKHKNNEDIDNTHKKENHNNNNNSNNNNSNNNNNNNSNNNNNSNNNSSNNNNNNNTEINNNHHEDNHNENNQSKTNSTNSNTNHSEQNHNGNISMPNVMESMSPIVGYTFQKKDNTPITHPINTYVHLLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIV0</accession>
    <name>V7PIV0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIV0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="141" mass="16122" checksum="FD419C526EF7884F" modified="2014-02-19" version="1">MFNYESIFINEDVVSEMTIDDVKNLKPYWNVQIANFKDSINEPVFTLLQMAILLNKKKIVGYLLARKSLDINVLSKHNQTALMIACEKKVPLDWIEAILKKGGDLGINVKDDFNETALDKCTFNSKAYQMLLKYGAIESVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ38</accession>
    <name>V7PJ38_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_03018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJ38"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000016">
        <property type="entry name" value="Prefoldin subunit 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB59571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10718" checksum="B3C19D43AD9CE628" modified="2014-02-19" version="1">MENNSITAIPKPNELTESKLTYEQVEKDRVQLVSKIEELYQDVVEHKLVLEALENVPSDRRCYRMVGDILVERTVGEIKPALIDHKNKVHQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ41</accession>
    <name>V7PJ41_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_03950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJ41"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB58323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="439" mass="52540" checksum="2A168207066192B0" modified="2014-02-19" version="1">MGNSITEKRSKIFKQNKSYFSDINNIDYTKKIIYFLGILVRIITYYYGLWQDKNLNVKFTDIDYYVFSDAAKYVLNNKSPYNRYTYRYTPLLAYLMIPNFIINFSFGKFLFSSIDFLVSIIIIKIIKIKYPENKNYILYASLWLLNPLVITISIRGNADCIPCLLVLLTVFFIYQKKIYVSAFFYGLSVNFKIYPIIYSLPLMLYLNKNYLNKDNIFQLKQIKTEGIYINKIIRIFYIIRNFFKELFKLNTDQLKFSLFSFTTFLALNLIFYAIYGYEFLYESFIYHLVRQDHKHNFSLFFYIMYLTIENNSKIIPLITFIPQFVLVALFGFKYAKSNLELSMFLQTLSFIALNKVITSQYFIWCTPFLPIILNSITLNRTNLILIFCAVLFFVIAKAHWLFWAYFLEFKGYNTFIQVYHFNTFSLDHQTYIIKTKVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ50</accession>
    <name>V7PJ50_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">YYC_03587</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJ50"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001213">
        <property type="entry name" value="DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="294"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="512"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="704"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETB58812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="780" mass="90138" checksum="E17E41337B4DFD27" modified="2014-02-19" version="1">MKLKKNHMNKPLWICSDGFIYLEMFNSCSKQASDFLITIAEPICRPEIIHEFQLTIFSLYAAISVGITLDELLLNLDKFSKNILPSELVYSITKSAESFGKVKLVLRENKYYIEAKDKFELDYLLNNNIIKNARVYSTDVNNNNDSKKTNIFNLNNNFMGNNRVDNNTGASSGNILNEEVENKKQKDAYVTYEAPVLDTTQLGFKISESEKQLMLEETKKNGNDNSNENSAEVYSFEVNCDKIEEVKQEALQTMQRPLLMEYDFRRDKKNPNLNCSLKSHVQIRYYQEKALRKMFSNGRSRSGIIVLPCGVGKTLTGITAASTIKKSSLFLTTSAVAVEQWKKQFEDFTNIHPRHIRILTSDYKFDLWPINEAGVLISTYTMLAYSGKRSEQSLKIVNDIRRREWGLLVFDEVQFAPAPSFRRINDIVKSHCKLGLTATLVREDLLIRDLQWIIGPKLYEANWVELQNKGFLAKALCKEIWCSMPSSFYKYYLKSNSFIKRRLYTCNPRKLMMCEYLIKYHEQNNDKIIVFSDNIFALLHIAKTLNKPFIYGKLSPIERIAIINKFKNDSTINTILLSKVGDNAIDIPIANVVIQISFNFASRRQEAQRLGRIIRPKNKANEKKNINDPDSFFYSLVSKDTIEMCYSDKRQRFLINQGYAYNVLSDNIVDFNKLNLVYKNKKIQDNLLKCILASTDDGNNDEDDDAFDDMNFKKETPKTNKRNNSVLSSNNDNLLRKSDSDGLLKLSTNMDITFNDKKKTASKKFADKHILFRKFLNQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ65</accession>
    <name>V7PJ65_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJ65"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="156" mass="17735" checksum="C75CFCA08FE1633E" modified="2014-02-19" version="1">MTIDDVKNLKPYWNVQIANFKDSINEPVFTLLQMAILLNKKKIVGYLLARKSLDINVLSKHNQTALMIACEKKVPLDWIEAILKKGGDLGINVKDDFNETALDKCTFNSKAYQMLLKYGAIESKNSSEENNIMEKTSKKCDSIWSNVCGCGTRYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ70</accession>
    <name>V7PJ70_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="778"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="819"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB58837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1359" mass="161257" checksum="B73DF1268B61C912" modified="2014-02-19" version="1">MANQINGIFSKLADMTIGLFRFQMDNINEEIDENMSPLEKAMLYGNSNLKCRKILFIKDIIKLLNNIDYTDFQRDIYPLIVKLSDESSEIKYEICNKIGDLCAYILQNNNDGCSDVISLLFPIVEKFIINYENNKNILRYILKSLLILSTHVNIKTRKKQIFPFLIYLICNDAYKQIGFILLIKMCYIFDRDNIVIYKVLIPFIEKHCISNNIECKILISSYFFNICKMLDESNFIKNQIFIFNKLCNDEYDTIKIINIFNCTHLSSIYSKNLFFNFFLPIFNNFLKNNNLYVFYYSLINLLLFLCIFEDINIIHPFYIRKIIFFFNNLFSSHLFTLNYLNEMAKKKTNYIFLDNTDGVYDDSNSAKIWNKDEKRDDTPSYPLNETDMVTDFQNSKSEKNNEHTIQNTISNELKYYDNYLNEDMCKEKQNNLVEIIEKDPTRQICNDEQNLTTGCNIISPINGKGLWVEDNKNPHKNSPMQELPQNKSDKNINNESDERDKLGIGNISCEIESTEESKNCNFSSESEILNKRKMEKVLFSSEISELECSSVQSLSNEIIYDENVCIFINNKLINDLIIKNHHFCSNISQFFKTHGNDYYKNGNCDKYFGRKIINLMEKNSDDLILENKINGETIESEEFEKDEENYFINLNEKDIKYIDNIFNHDDNIDILQIKGCYYSELEIIKNDIIYGKMLLRQKRNMYKINNNNKCDSSDNITYDIDYEDIYAIEGVDTDSLKKLFLFDTPNNVIVSYNINAVYIITLHIPGLILILKEYFFRFFSHVFFFICTYPYYFVRKTIASLFYDILSNLMESPFFKINTDKLYEDRINMKKQKKNLKKNKKIEETAKKKLKEECSDDIKKKENNYDGEDSTEQSNLYTYKENNIKHQDINHIYKKEPPEIVQTFNNDYATYNNMKRIQNNSFLTSDKSCENTEDFINSCIMEKHEDVLEKEENKLCDDTLDMIYSNNSNTNGSHYSLDQDDTKNITTDTIDQIKEDKNDIQLKRVKKNAQGYRKKWSYDKMIKKVQNKINNNLYANDFFINEENENFFFYINFLGKYEMIYIKYIQKFKKYYSDNSPLHFFHFFIYYFLNDSNVLVKKAILKNYDKIIEFFPNNIQKIFIKYLSDVVNFKTLNYSLRKKVSKIVFKILSKINDAKIVRNCLFPIFMRLCKDEAAIIRTYTSNYFYLFIEKGCPRIYNFFKNGGEILPLEDYKKDIILTNLENDELRSFHFISGEEIYILKTVITTFYKSDRFYDRQVFIKICDGIINECPKNLFLLYFLKPFLNLSDDKVHVVRMTWENCVVSQIQKRGYILSIPSILEKLNNFHEENNINCIGTNIDYDVNKYNSISIETFDVDDLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJQ6</accession>
    <name>V7PJQ6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CAMK/CDPK protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_03084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJQ6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001036">
        <property type="entry name" value="Calcium-dependent protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB59654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="217" mass="25623" checksum="AC6DD867662A78AA" modified="2014-02-19" version="1">MVKNEINYLSIMSHENIIKLKDFFEDKNKFYIVLEKCEGGELFYKIVKNKCLLESESIQIVRQVCCTLEYLHSNNIIHRDIKAENFLFKNKNTENIKLIDFGMAKTVNCEYLTELCGSPHYISPELIRKKYTLSSDIWALGVMVFFMLTGKYPFEGKNTQKVVDEILNKNINWKDKEFSSLSVEAIDFLKKLLERNERKRLTAFEALNHPWIKLEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJR9</accession>
    <name>V7PJR9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJR9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000010">
        <property type="entry name" value="Probable inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB59235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="386" mass="45597" checksum="DBCA6530D17E3C3D" modified="2014-02-19" version="1">MSSKKRSKTATLSNIQKRKMSSAIINPDNRNLLNMDVKNEYNVKTNNELKVNLNFHNNNIISNMFSNLSLYESMNNFFQINNKHYMLKYNNQLNQTDFNISYFQNINDKYVQISPWHDIDLMNSDGTYNMIVEIPKYNYIKLEIKLTEKYNVIKQDTKKGKLRYYHNSIYWNYGALPRTYEYPKHIYRCKGSDDQQIFFTGDDDPLDVIDIGSNSLKMGQIAPVKILGAFTLIDEGQLDWKIIAINKYDENYSNINNLEDIEKYYPHTLNLMIEWFRSYKMADSKKLNIISKKLYNKKDSENLIKKVHDYYLEFLKDIKQFSLSSSCESTNINNSSNATNSSECFQTSFSYQNPDNPVYNNLVQDVSIDYYKSDDTYRPNMEIWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJS7</accession>
    <name>V7PJS7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">YYC_03200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1240"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1241"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETB59816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1615" mass="193377" checksum="16583EDFC3F4895B" modified="2014-02-19" version="1">MMPNARLILERIIFIVIYIGTIYTFWNYMNIYNASIRYYSFLALIVIYTTSYILAILPEIINSIKDELFYKTRKNKIYSHSLRKDEVSKKRKKKDNNKGLEFSNSIDTNLLYIHQGNIKYEYINRDNNLRIHNTWNDIEENEIKNLEEGNYSSEYDRDDEERKKEKNIYHGEINGNKLHEEENQTMDAGKVDYHATNGEHNINDEINDYILKKKEKNKKYIIDSINDIEDIFNDDQTKTLKMKDQMIQFIELNCMDSELEEANDNADENTDENVDENGNNHKTSKKDFYKMGSIKKMNNMIISNNMSNNEDQMIYNKKCQLNDLNSYIHMSLKDIKRANESFLYDVKYLNTKTLDFLTDNRELSLMWKADSMRAKRKQKKRKYIYFMFKSRNDSILGLSNSYFSWFKPNGDKYVLDSFYERNKQVQKVKPFSRWHNLLLKIIINIKVTYLNFCKNSSFLISDLIVTITLLLTWIGAYNYFRRNDPLTDRGMFNWNTDYLPNLYITIEGYLQSIILYDICVKLILFFISHHMFSFWFVLNMLNTPFLYILISKFTMVKYERYGWLYLTGPFRFINILRIENLFVENTNRYNKLNLPIITLSMHIIILIYTYACIHLLIEQPCKGDYQLYDYIFSVMQTLTTAALGRGTCFPFSLESKIVHTFYICMVFTYLHYKIRYLKNHLVEDKQIYGKIPSIGSRYFVIIGHIKPIALYVIINELQSTYNNIDDIIILTSLPVRFYLNIIKLLNKKGLIQISLCRYDLNKPFPLTIKKIISYSIGIFICNNIMNTYHNINNDIETLKRYNEIKSLGPFNKYTSVLLNNMCNYNILLKKNYRNIICLNDLKMKLFAKTMDDCPGMFLLILLLFINVPQKNQSKSTDLLKKYFDEINLNNDSENEKKYRKKKLYRWKNNTNDKLKRFHTSLGNNHNQEKEINIFENKKNNNYNIEIIEDGTNHNYEKIKDVDLKVIDENTQRKANKISESIKKEKYIFNLFSKFNKNKKRMSLFPYMRKNIKKKFYNSTNEYSYHYNSYNNYLDYIKGIKYNIYKIKLPTLFFNLYFTTIAHYMYMNYNVFVIGIINEYSEIKLNPIDYIYKNEDVHFILLTDKYNILQKIKNIKNIEFDWNNNIESIKIKINKQKDAKKNLDNNITNKFIDKNCNNYYNNIKKLKCDISRKYFDPVLNIFRVDNYLQALEIFKLREKQDNHMRASSNDSCCSDVDNKMKKNKNGIKNVSNKFESYENGEKNVSLSSMTDSETDNIKSKNDKPKKKTCKKHTPNFMILINWAQSLNTFLKVLYKRKKHNIIILSDNVPAYIYNNNLSKYNICYIQKSPLIMFNLIIAGILVCKKCVIFKNYLKLNSYENIISHNEKIGLNYFEYMCKTNDNDTIIIFNNIQNIFRRRDKKDAYIDFFINENNNFNAYNDYFKKKMSMKNDGNTYEDEERKKLLKKIKKNDNKNERKNNIYLLIELNNTLCIQYLNNDPYTTINVVKNKLHHLNMDIAHNLLFIENYKRQIQFFKYGNLLVENVYKKIEHIFIDNYYFYLYFLQFTSSNVFVDELIYHLIGYTFPINNNSIDISIIESFIHGTYSDENKQFKANLLLKKIKLKYHGVEFFCIFQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJS9</accession>
    <name>V7PJS9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Formate-nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">YYC_03481</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29415"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetate(out) + H(+)(out) = acetate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71803"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>formate(in) + H(+)(in) = formate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:80887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>pyruvate(out) + H(+)(out) = pyruvate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64720"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJS9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00790">
        <property type="entry name" value="fnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETB59245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="302" mass="33391" checksum="91E6A3899622FDC6" modified="2014-02-19" version="1">MGKTGKQYILDPPCVKTTCSSEESYIRCVEYGKAKATYSNFNLFLKAIMAGIFVGLCAHASGIAGGLFYYHKLRAYVGASFSSFVYGFTFPIAFLCIICTGSDLFTGNTLAVTVALLQKKVKLLSYIRVMLISLLGNYIGAVSFAFIVSYGSGAFHQHSDIEKNHIYEFLNAIAIKKVHHSFFECISLAIGCNIFVCLAVYFVLSIKDGSGVVFSVFFAVYAFAIAGYEHIIANIYTLNIALMVKTDVTFFDVYFKNLIPTLIGNYIAGALVLACPFYILYRHYYEDYEAKNSSLGSMNIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJT4</accession>
    <name>V7PJT4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1462" mass="174445" checksum="EF14B2BDEED62721" modified="2014-02-19" version="1">MLKRDSLINLHKKETRRYSQSKKTFNYEYPEYLTLCLEEYKNNIYDLDLINDNEECMRELVNYYNYIYRNCYENVVNFFENNNNEKTYGNENYVLKFDLLNKRHIECLYNISIFSISDKLKYYMLRGEIKKKNDLGNGDIIDGERNNENQAIKKILYGNDGIKHNNTNSNLIEDFTNKTKYLENNSKVYTNDNVEPNEIKKDNFDIIKYIFYVIRLIEYSLSTQTRNLSSFYNNIKVYFFRDNTNENYYNNIYLLILCLHCLENISSNIATFNIRDMENEEFFGNEQNNSGYISSENVNDLQNDIKRKFTNSNFRNRSVTSEISSNFHQSNTINNNNGNTNDINGISNKNYLRQNKDSNSFRICNNNIYFYKIFFYLLNLLNFYLEDMIKDKSLLYNDMIKLHADYNLRRNRKDSMFASSNALNGTTNNNMSSFVDGKDELFFLGKNKISYCNILLKCLNIINNLMNLDFIRENIMNSSNDLNELKIFLSKYYKYLNEYEDVEIYKQFYMSLYKTYILFFPEELEKENYFSPMLFFENIVNNGNIMRMRTIVDTLIYCFNDKKFVYFFEENINITKVLFIFVTYSSRLLSNKHYELITNISFLFYIILIKFPNVSITIFHILNENNDYIMKYNEDKKFNSIFNNINENINMLFLSTIHKNKNLATINSLIFSKFIHLYCQFCVKKNNLDNIQTNTNNHFTYGTYLSTNNFSSRNSNMLYMNENRQNGSNANNMNYSYASNNENDPNKLQKEIFVSAFNNIKLNERNTVIKVILTTLHIIPGSYSSSPILPIEENIEKTRYIIVIINFLFTLMKTKFYENIHENTFEYIDYFIEQLKKSVSMKNIKLVCGYISLLLNYSLNKKTNNLNETADLKSSVFIKNIHYNNQPNIIKIHKALYESGALTFLISSLYESKDSLIIYNCIYSISFLLYKKSILDIDKNIELANMKIAILNIVRHYYNLDNYLDNYTENFIDYKGFLKGNSKKNLTSQDDDSYNSFLNKLNKRSSYDRDDINRKYLYEDENKFLLNDKNDKYFPRHMTANFSKNMGNNEHIGNKSIFPSLKYKYENANYENSFFRNFDKIFFETVKNKKSSFNFYFDTIYNTQYLFNFLLHNFLFYSKDADEYSKKYLLNILLHNNITRSSDISFYSNKIKNMNSQFNEFQSRLELYKQDLERYKDVINVLNKEIEEKDNVHNTLIQKLKKESEIELNRKLQETNNLENIISQKNDIIDELQRKYEEMYLQKKETEEENVNIKNRTVSMESLLKSLQTKYTQIQSQNKTLNNKLNDQTNRINEGINVINSLNSENEKLKTIEENQNNELEGTFKKLIVVVKELSNKKKELDEKDKNIKKFSNDIQELKTIISKSDNELKEQTLIIENFTGLNKNLSEELNNANKNLEISKRYIMNYEKNEEEMKNRIMKLEKELYEKTEECEIKTQKLMLKEKELADKEIQLKKIASVIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJT7</accession>
    <name>V7PJT7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJT7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="416" mass="49124" checksum="29301E9ED2A27595" modified="2014-02-19" version="1">MLYIFSSLDYMYKEWNFLNIICVILTFYSIFYTKTVFSKDYGNNIYDVLYVASISYILQKRFNTKKMGIHDFQHCINSETKNIIDLIQKGVILNIIPLIFSYVLSFIIDILLTIINSISFNIILSILTHPFDVILNLPSIYNLSNIYVLSSFSYCLSILSAIWISAILEYHFIIFNFLFNKYDYKVLTSLNKFPMHNQCSYHDEFFVVTCIYNYLKDVSYRIKGHNIEITNMDKKTKLKLLLFKKLILINASLKYKDEINILSHICNPINTILFEDNKFWNTYIDSCILCIEDLICQLKRYINILNHNQTVYSIEEKLELKNIMDKHRINKLKDTIVLTCIYLKGVSLWSIAIIIICKNVIVSVIRKLSSIIVSLSYVLFDFLNFIKINELYDPLHHLLYGKPKFYISKQTNVFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PK41</accession>
    <name>V7PK41_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PK41"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764186" evidence="1">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="135" mass="15986" checksum="49E7B108EC4EFEAB" modified="2014-02-19" version="1">MRIYYLFFFLILIQLNLVNNQNLNQPNNANPLNRDFEKDMEELDLSGLEDDIENIEEIAYKDSYTYLTQIYIYVRIDGDYSMYKSHSNLMKLGEKYMTLLQNAMLNVQLKKNGVGEFICFYQKKGSNNQILINIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PK48</accession>
    <name>V7PK48_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PK48"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="415"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="500" mass="58649" checksum="582BB5DEEC7C4394" modified="2014-02-19" version="1">MSYLLDDKKLVLKNLISKNEAIKRENIHIELENKAFLCLIEKYGEKKKILKVIEYIHYVCTMLYKNEEDLNFINNDDNFLKTLEKLINNSILRPKIICKNILETNKDPLLDNSVALDSHHHFEKTTIQPGQEKGQPDQEKGHAKNPIYDVNINDIISLKSKINNHAENAENVDNAENDENDENVDNDENVDKLSKDSKENIKAVDVDSLNRDKENEVETKEDIYLRKEKNICLHWSEESSTDNFVYSEERDISPKNNITELNLMGKQQLIFNEIEKIKSEIKELTLYLENTKIIVNSVICQCKIFLFDINDEIKNYKNMKENIKKNNFLLKKLNTINEFYNNIMNKQKKKIEESQKTNNTLINLYKKKFINIKYILSNNKDINTVDFLYLHVLIRNKKINYDHLMRTHENDYAHLRKLINDINAIDNELSENEKKEKEILANLEKNNAILTEMDLLIISLTNKINKINKSSNKINNYEHIDAAGNFSVIGFINLNKEIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PK54</accession>
    <name>V7PK54_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PK54"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764151" description="Ribosomal protein L9 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal protein L9" evidence="2">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="149" mass="17595" checksum="94E1FD332560765E" modified="2014-02-19" version="1">MHCHFLLITFLYLLYLRELTEGYVTYNIVKSNSTLYAVKKKKKKSSKYIDITVSSDNEIGTKGEIKKVKLSHAFNYIIPQKLGYRSTINELVDKEKNENTLRYIDEITKSFIWDYKKKLNDLIVPFEFEKNQNILVTQDNLLDYVITLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>V7PK55</accession>
    <name>V7PK55_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="6">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">YYC_03206</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 32">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="6"/>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PK55"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000068">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 24 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0140">cGMP</keyword>
    <keyword evidence="18" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 24 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="28">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="28">
        <location>
            <begin position="145"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="28">
        <location>
            <begin position="264"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="28">
        <location>
            <begin position="387"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="510"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="29">
        <location>
            <begin position="768"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="23">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24 25">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="ETB59824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="821" mass="93907" checksum="8E30EBE6288ECDC0" modified="2014-02-19" version="1">MENHLELRDKLAEDIVTIKTSLKNNLVCSTLNENEILALSNYMQFFVFKSGDMVIKQGEKGSYFFIINSGKFDVYVNDKKVKTLTKGSSFGEAALIHNTQRSATIKAGTNGTLWGVQRSTFRATLKQLSNRNFNENRSFIDSVSVFDMLTEAQKNMITNACVIQNFKPGETIVKQGDYGDVLYILKDGKATVYINDEEIRVLEKGSYFGERALLYDEPRSATIIAKEVTSCASICRKLLNVVLGNLQVVLFRNIMTEALQQSEIFKQISPDQLNDLADTAIVRDYPANYNILHKDKIKSVKYIIVLEGKVELFLDDESIGILTRGKSFGDQYVLNQKQKFKHTLKSLEVCKIALITESCLADCLGNNNIDASIDYNNKKSIIKKMYIFRYLTDKQCNLLIEAFKTTRYEEGDYIIQEGEVGSRFYIIKTGEVEIVKNNKRLRTLGKNDYFGERALIYDEPRTASVISTVNNLECWYVDKSVFLQIIEGPMLAHLEERIKMQDTKVEMSELLTERIIGRGTFGIVKLVLHEPTKIRYALKCVSKKSIIELNQQNNIKLEREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSRSQAQFYLGSIILAIEYLHERSIVYRDLKPENILLDKQGYVKLIDFGCAKKIHGRSYTLVGTPHYMAPEVILGKGYGCTVDIWAFGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVTDTDSINLIKRLLCRLPQGRIGCSINGFKDIKENPFFADFDWDRLAGRLLEPPLISKSETYAEDIDVKQIEQEEEDNANTEIDDENWDIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKW6</accession>
    <name>V7PKW6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKW6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="112" mass="13015" checksum="E1623DE10B285AA4" modified="2014-02-19" version="1">MYAYMTKTGKSYCINEINNLMECSRSPDASICSKEFLLFRECNRPDGPHILIDDNKYLISKKHLDKYNVNNATIGPIEAPERNNSNTATFLGKMKETLHLKNFKENFIAYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKX2</accession>
    <name>V7PKX2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204:SF0">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1313" mass="151949" checksum="2201A8732C4162F7" modified="2014-02-19" version="1">MEEENIKIKVKSIDNQECEFCVKKNTTAEELKNMISEKKNVDVNDIRLIYQGQCLSNTKTIAEYNIQNDHIIHVVIRKKENINNSTYEKNNKFKNIDHDSNNNNNNNYASSTTPINDPLQYGFASSINFNTTDSNSNNNNNNNSNNNNNSNSSNNNSRPFGNTNIPTANIGGATPLYFTHMRLTRNDNLENDLMSQTNMCSLLNDIMSQVNINPNFIYGAAASAVNSVGSGENFFTANLRPNDANININEFRANKEKDQNCANVGNKQKEMDKDEIEKENENVSSEINCNDVKTGGEKGASNDNNDNNDDNGSGNNNDANGNGNNKHSREGRNKGKRNNSSSNSSSSENSSYEYNKNKKESDEEKKKKLKKKLKKKYMEKIRNKYSENINDIYSSSYSSDYESSYSEISDRKERELDDEKKKRHKNKILEKLRKKKEKKKKKYYYSTNSSSDYDKKNEKKKKKLRNKGKFMFDPNLLYNPNYMRNIYRGMCNPVQYNTPYITDINKGNYLRQNTKFNHIFNNNNNNSSSSVLRNVPYPYMNENDINKSMFYYDQKYGNISENENYINFKEDIPYEYENMKRFVNKKIYKREELNNNGKKRMINMNKNISDANNNNNNEVLFGSNFCNKTENRNINDAQNFIKNSNDGFTGGMLSGIAAQNSNNTATTTNNSGNNGNNGNNNGNGGNNNRSSYANIIPFSDIEVVRNNSIGSNSRSALSQEEEELSENNLIDEQMRSIQMASNNRRHLRSTSKLLNDENDFEYKNIELNIPWRIMDQLLVLLEEETGYKRPNLSSYINSYYNTNSIYVFFNLFVHINNIINSIIIQFNHSNFLNNDISMSSFSRISIILSLASVILSRLSNFFFVFYDNFYYNNYGRSYRYSEPINHEHLRELRNLYYSTNRNYNIRNSNISNLNYDQNNHFNNYRTNPNKTNLQQEFEDYYKNYLNGIDIDVNNNVLLRRDHPNFKTKNFDDNINNYKFKNEHKLSNNFIDSKKNKYNNNKSTDLKSRLKTDRDWNTNNPFSTLQNYNKNHNPLLYISKTKKKKNKKNAEKQKKNDKDISKNPSICSSKNSHNDSSKLGNNSSSQFGNNNNEPEIKNFPEPNVADSTTQNTKDKGNFMMDIFKNILKNESEEKTTKNNINDKNCLKINEKTNNTVPNTALVCYDNNMDDMYGTSDEEKEQTNKNINNEYKITEQKDSTNNPLSFEQNENIQKNDGKSNDGKSNDGKLNDEKHNSSNVDTQKNDKAVVNNLPIPNINFANILNDVQNQLATHKAPEAPHRDKFDGVPDKVKERYANWTENSQIFSGQVRKKNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKX4</accession>
    <name>V7PKX4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKX4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="154" mass="18562" checksum="8C5C2D032563925A" modified="2014-02-19" version="1">MENKNLSFVFNYKALNPIKKFILDKRLHKYRLIFKNLKDQVLKIYTIEFEQFYKTHSTEISYSSIENFVWDFFTYAEMCLSEQNNIEKTFEIAFDLLKDCEDNSEINESLKDDWELIPHESQNIYKKQILKSMHLSDNSDPRVICQIYVESCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKY4</accession>
    <name>V7PKY4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKY4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="451" mass="53862" checksum="A8DD2B4AECC3F944" modified="2014-02-19" version="1">MGNLDNENAEELKKKIIDLELQLEYEINRHEDEIKERDEALKQMEEKLIEMENIKSEMEEKDKAILNLSEKLLIMSNKYDILVKEGKLKDEEIKHIKNKKKYKKQATDEYIATMKKQNDEFKNDNDAIHEKYDQLLKQYDTLTKNYKLLEDELNKNINELDLEKTKKMNEYDEIVAVKMLNMDKELRQKRHTGNDEENSLKLELKYKDMIIKKLIVKKEKEKILEKKEFGNKEDTNNDIDEQIINYEKKVNELHQKCIDSQSDQAQLKNKITKYSNIIDDLKKENNELLEVISTLREYINTTYKEDTDIHQYDDLINNLLKENVTLNEEISKQKKKNIADVYYYNKELQMLQNDKMKIIEKFDIANDSVPHLYEPLNVTLHEKKGDEKNEKKKNCYKNSHGTIIQELSNNSKKDTNLIKGNSDSPKDLTINEDWAHIYMQDYMKNVETRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PL81</accession>
    <name>V7PL81_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PL81"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="466"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="580" mass="68718" checksum="BD207F86C1034720" modified="2014-02-19" version="1">MLENTIEEKKSIDVELDTSIKFCEFIFSKLIFFSNYENNNLAYLFGFNCLRRHLCSLISSFLNFNNSASRRKIESAFTNQLINLVKKIFENIKIESDLELKVSYTELLWRSFRRIDLTTFNIKSLGINIETLEKLKDFKILKFDEECISWLKEKNYIDKKNIIENGSFSISANKSIVNKDFILCYLGNCSIFLYYDNTEENEKCKIEIPYYHITSIHSKSKKSFTLDCKAIAEHTNIFCLWSEDAKNSIDYETVNKLSLSLKIKKTSKGIKELSTVLDNIILKLKTEENKNEKETFEWKKHKNNKKKYKKNESESEEREAKKRFDRSEVLSNSSIDDNNDIRDVLKNTRILKIETYDHEVEKGKKNEGNYKSKHDKPSNVKSYENKNVLKKIQDHERMLTDYKFDLNTPRVNEKHQNDGDRDSDIEIMIEKIISCKKEKREKFKMDVKKKFSDALNDIDTNIKSLIEKQKCRRDELQKKYEKKKKNIILNTEKEIAILSKEMNVLIENMKKISLNKNDVKKLYEEGKSIFYPSEVMDKSQVLIQRIHEKLEKMNTDIVEKEKEYSKRKKLCFKALATAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PL85</accession>
    <name>V7PL85_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PL85"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="128" mass="15309" checksum="AAC27CFF845B7AAB" modified="2014-02-19" version="1">MYIVKIMKIVYNCFLVFLVVVMQKLYGVSSNRLEKEEGNFMNFLPSNSLLYPLDFQQNWQASEPIPVTIHYNIPSYGHKDLLMALESYTDLENYQKESEENKRRIIEEQNRLEDILWNKIQLIKVKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PL92</accession>
    <name>V7PL92_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPI-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PL92"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="1" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="1" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1058" mass="122345" checksum="FE98E0308BB95235" modified="2014-02-19" version="1">MGTLDLENNCTLYICTDNCEIPSVSEIQKKLESQNVDNKIEGMENLIFNIIQGEPYGNLLMYVIRFIVPHKDHRLKKMCHIFFEVVDKCNNDGNLKEEMILVCNALRNDLISPNEYVRGSTLRLLSKIKYLKILDPLIEAITKNLNHSHSYVRKNAISCIHTIIKNHGIDVIPNAVKEVEKILFLETDISTKRSALSMLIDIDPLTTLKYILSLNDQLYDTADVMLLEVIQLFKKLFIPQIFDDSCLKINGNKDMDDDICSQYDSEKDDDYCEDDENEFDYSQNDLSGYAQNSNDNNILNFKSEEIRFKNKKLNQNDYMPYKNNVINILLNMLNKNVSNSVLYEGSCCLLYISNSTISVKTASECFIKLLISQHDNNIKLIVIDKLYYIMCKWKHILGNYIMDLLRSLNFPSKDIKIKILNLVLHILTKKNVHLVLNVIKKELLKLNEEFIYNSKELISRGNIPNNDPNKIVPITKDEEHGGGSTKVSNLEGFNNAYNNNNNILSNVIDSGNYKKILIKFLQHICNMYTTDCICIVDLLFIYANTQEKNINYESAICIKKLANNSVLQNNILDKIIENMFEIKETTILRIFLWIVGQYMNKNKMILNFINILYEQMSYFLNNNMEESDVVNKLFNEKLKKNKFLNYNEISNNITDNNTTPYFQNIQTKTVILEDGTYATEAFATTPNKNPINLSDSNKNGAKFSANNNSSLNQFLYNLFCENDDLLLSVLCVCITKLYLRLLSNADDVFNFIRLASNIDEQKCGEKCGEKCGEKCGEKCGGKCGEKCGGKCGEKCEEKREENHEQNYDPNLMLKNLNVFRNKSIHILSSIIKYTTQKNIKSVTSVYENDSNVIRITQCLNIFLKLKVGIKNIDNETKKFIETFINGDKYYHDFIKKEEDKYCSLYGSSFKNCRKIETIEDDINNEDDNINNEEDDNISLISDNEMENVDSIINFRILKENKNVLNMLDDEIVTKNENFEQMKLKYSLKNDILYDYNEFKYPIINQDNYSSLFLSKLHKSQPITSIADDIFIEIFPIISSINLILEFYIYNQSVTPSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PL95</accession>
    <name>V7PL95_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PL95"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="28014" checksum="A2BBFC8C6546A020" modified="2014-02-19" version="1">MLCINHQIMIVLFHLLAYYSISNNIISHRFLYTINIIIIILKEVLVYDIHKSLNDSFKNILDTIIIIGIIWILSPVMISLTQTHSDDTVYLVSLCILLPIHFMFHNYGFIYEKNENIDIFDSTSLSCVVVESVILGSRLPSIIQVFSFLFCSSILFFYTPFIVQTIVLKNINYYNYVLFPIIFIILSICIRSISIPLFYVNLFGHAFILFVIPALFVNKHNSKTVLEGPWDISGAPFVQKNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PL96</accession>
    <name>V7PL96_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PL96"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="239" mass="27886" checksum="0A9954FBAFC337D6" modified="2014-02-19" version="1">MEDPNLSFKIINDEGVEKFMNSQIYQDIINFISDLNTSVIGVEMKPLDKFVLKSENNENNENIDNIDNIDNMLFLSKNVYNILQLIKTMNVCIDKCPPIKHPTRFGNKAFPNFCDEYYKEVDQQLPNILKDSGISNISEHTYQLSFYLKNSIGNKKRIDYGTGHELNFLLFLFCLNKLTFFSTPDHRHLVLVLYKQYLECVRRIQVVYNVEPAGSRGAWGSRKRNWLNYGHQNICISTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLU8</accession>
    <name>V7PLU8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rh5 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031789">
        <property type="entry name" value="NBD94"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006499">
        <property type="entry name" value="Reticulocyte-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041668">
        <property type="entry name" value="Rh5_CC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01612">
        <property type="entry name" value="235kDa-fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16830">
        <property type="entry name" value="NBD94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18515">
        <property type="entry name" value="Rh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004765411" description="Rh5 coiled-coil domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="2728"/>
        </location>
    </feature>
    <feature type="domain" description="Rh5 coiled-coil" evidence="4">
        <location>
            <begin position="189"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="NBD94" evidence="3">
        <location>
            <begin position="1168"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="742"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="922"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1645"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2052"/>
            <end position="2079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB59303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2728" mass="320736" checksum="7775D371807613FC" modified="2014-02-19" version="1">MKKFVHIITTYIVLFTSLVYGKKIEAEKRNHDAQLNNFYSYHNSKGVDFNNSNSSNEEQCNNQNNVINDKIIQPHSITYFGNQKNTANDKVILYNDYTNKNDFDTFKSFNNENEQTNREATIVKSSFIQNFVTPTFDHSLYNIIDIIYGVSIPTNSLNFFYVKLQAYQEIRDILHQIYSNSTTVINISRSKHYNAYNDIQTAIKECEPQKNKVINEMFNFQSPLYEFYKNPMHDYYIPYEDSKSQYVNCMIPRFKKLELKVDNSFLSVVPEYDHLAYYENRNVDVIYKKYATNTKNHMIFQLGTINKYPMFSDKETIPYIKSLIQILESENAQASLKKKLFFLEKQFEDIIDKSNKSRVKCIRAYQYMQKYQLDGTFIRYYYNYFPEFKKIATHKAIFIYNSGNLQSMESVYKYQKEVLNRFIKTLGKLLIEKPDPDNNQILKDDIDEFNISIPKPNLTALETRFFEIFKQEWGSYDNKKTLGKNDDQDNTVSLILMRMKDFKDIIDSMELYKRSVVSKNKILSEIDQKLNKQTYKEIENGLKESYTLAKDWKTLKRKIRTELEGYSEDSIQLEKEINGLFDKYLEINNASIYLSTLKIELKEKIKNISDKNEYVKKAVDLKKIIENNNTYIDELAKASPYQLTEYVNNKDTIYSTIKSELSKIYEGDIDELYNELSSIVKENDIDNAEDKTKLEDLKSKIYKEYNKIQNMETETVELKLSTIENSKNELLSTIVKIKKYIYGELNNEINKIVEDFKNKENQLSSNINEYSKYNEELNKYKSKISEIKNNYNDQSNIGNVKDEEAKQNYEKYKEYIKTISTKEDEINKTINEMKRTKDDILNKVNLFTDFENNHKEKVNTEKESFIELVNKIKKEISDDQLNNYESKFNDTKSLIVETNRSIEMEYKNVDTLKKINGYLKICKNTTESIEKLRNKQNELNEILNKNIETVKNCNLIEQSYTDKFNNTLTDKKTELEKKFTELSLNNYEANNNELITYFNNLKENLGTSEGNILYQQLAEKEKTINDIEQKNVNANKNVSNIEIVIHTSIYNISEEIKKLIVNNAELLNKEIFKEAQISITNLNEIKDKLTNYNFNDLGKDINIKNDDEVTKIQNEITVLNTNISQNIEKLENIKKKSENYVVEIKAQIGHLEDVTNKTLSNDDFKKIENKQETIVSKIDKTKSIYENMNKLVSEITEIKNNTISLKNIQNINLSYKQSLNKLFGDQINKEKTNSENMIKSIEKCKTEFDDIKNKLIAEKQTVNVQYFKYKEFNTIIQDNEKYFSDIHEKSLELIKEDSEKSNINDIKKTLQGYLLDAQKRNNDINRYLSEITNLYNILKSNNIKNMIDDIKNYAKQIEEYNKNVKSELGKSETLIKTLKSKFQLEKCKSKIESTTNDEDAVECIKNITEFKNYILNDETNINDYFKKAEEYNENVLLNFKNIEAAYDKVQYMMTTKSDSDTNHNIYNSDELKGYIDKSKEYKDEVDKNTKTIENNKKEFEQYKDEAINLLNKFSELMLKNNIIQTKTDLEIIINEIKKMHKENIMQAEKSEQKINTIKNEQIQIKDDTTNNDKSNKAIIGIQASLDKFETKFLKINDIRTKSNDFLKETENIEKQISNLSINSQGIKLKDNEDILNTLQTFLESLKDQKKNIEYQKTELDNFDSEIENIENNINHNIKNYEMGIIEKIKENADTNKNQIESTKELIKPTIENIISSFNTSDLEGINTNENLEKYNTEMNKTYNEFMESYNLIANYLETVSKEPITYDKIKNTRINAQNALLKNVEHVNKAKSYLNYIKENEFDRIVTHFKTKLDNVNNKFTNEYTNINKGLDDISKYIENVKNSTDENSLLDILKQTKHTYMNMIGKAYYNYKYEAENIFKNMVKLAYSLNIQIQNNSGIYLLDNINIAILSSLDSETKDTLKFIPSPQNESEIYTKIRNSYDTLLDIFKKSQDTHKKEQYTLNLMNKNRHLYEKIHVSNELKGAISDTKYKKEKISNDVKLVLHKFNELNQLTCDSQNDDITLELSKQNQIKTKINNYEQEKKKFGMNFNVTTIEEKLDNIIKTLEKFENNRDSSEKKDSSTQSNDELNDMTKVFNTEIKSIEDKIIEKNDLIDKLIEMRKDCLLFTYTTLVETLKSKIFNYPEFIKSVTKVSKTYLEYIKNSTDSLNDDIDTLQTKYNLNKTNKHIASNITYITNDNNNLIEKEKEVTQIINNLTKLFSIDSNNIDANTLHNNKLQIIYFYSKLQKSIESIRQLYTKIRAFKLSNIYLINEKYLDISKQFDNILQLQKNKLTESLNNLNQIYKDISDKKNQSLRAISESTIPNFNVLKEIYHDIVNRESQVHEIENISNKENKNITLYIDTITQLTEKIQNILNFVTTNENDNNIIKQHIQGIDEKHVSKIIEILKSTIQSFQQIKNKIYEIKTQFYGSNNINNIITIILQSANDVKSLFSMDLTIENELIQIQNRLEDIKNATRESRSEQMDTYINTMHNYVERQFNKIENNPNKNEIDNTMENIRNYNKESEVKLQQISNYKNQVASIITEITNLIALIKPKYNDNNNDISYKAAIKHEEDAQKILNDLNKSQNILNQSINKNKKSIEYLGYKQYGTHYHNNLHTINNQQEISQIKYPSNTYYNNIDNAKYKSHHYSNSGRKGSSKTKHAEDSIKYAGAIVFGLIACYAISIFKKHDDTNEMDLDNNEKNYGESENNYFEREEEIIEININEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLU9</accession>
    <name>V7PLU9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLU9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="29315" checksum="D9B1E982E0EA2B47" modified="2014-02-19" version="1">MHLLCTNPEEAQQAAEVMDEARKRFLHYATSNYNYNLYENYSENASSYFRKYKNHTDIGKFHIKIYYPHAYDEIVNILWDPNGPKKYDSDLISGKVVRVYDPNLLMIQKSQRCYTTLFNRYFYALSAKYKVSEDTTIIVMASANINDHNKKNVKKYENVIVTSANSFKTDVDSEKEIRKGKLKKMFVNLSGYLITKHDKYVEIIHIDSVSDNIPIASEWYILLSKSERMGILLDLDNYIDDKYTFPPKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLW1</accession>
    <name>V7PLW1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2138"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2206"/>
            <end position="2236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2266"/>
            <end position="2389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2426"/>
            <end position="2450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2569"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2608"/>
            <end position="2627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2683"/>
            <end position="2863"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="945"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1743"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1941"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2144"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2206"/>
            <end position="2222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2275"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2312"/>
            <end position="2321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2353"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2428"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2573"/>
            <end position="2593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2617"/>
            <end position="2627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2683"/>
            <end position="2694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2710"/>
            <end position="2772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2783"/>
            <end position="2824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2843"/>
            <end position="2863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2863" mass="336889" checksum="966EC98BEF23CA2E" modified="2014-02-19" version="1">MNNNMQTSDKNVMENDKLNFESEASKLLDLKTTGNYGVFGLGKDTNLSIANTNIRDGDIQMDIDFLDMEKELDLLNDENYKKILEGNNNNINNGSNINGTAIDVGNSSISNFPGDDNMIESLCINELKSEEDDHLFSDRNYADKDELISMLRKKLKFKTKDYNLIMDTLIRTKEECSKKTDQIKELQTNNNKIEKECFELKKELERKNSQSNLNIENHSFYKKEYDEIKYKLVICEDKYKEVLKKNESLNKEITNLKNEKIKYEINKKTEIEKFKLEEERLRDENEKLTSKGNLLINKYLEAEKKSYAIEQKYKEEIQNLKNILNKEEINKKNSIQNFAKVKDILSQSLAKSEESYKQVVQAEKERDNLKVQNENLQNTINDLKGKIDNLKNCIKIFENKYKEIIKKNNNMFAITHEFINQKNCKIIILRKNAEIKDVFEKYKINKNIFQSINDFSALYIYEILLQNSSKIDETEMTEFESGTYDINENDDKYIKIKKKKYITLNYMLNEAQIKIITLTKTKEHYEKLYSSGKNNLHKDDESIYKKHYLSSDMTNLYNEKVHFENKLVEKIEYIKNLENKLKEKESLIEKSVETNMRLRLEKDTLIKVISATPEFISTVHQNNANYSIQAFVEHTVIEYVQKYERQKRGNNNMITSSVIDDYNQQTPSCVSNNSGGIKLSHTEEYNQRNLMSNLVINNIHERKIKKKDFSNTTYNGNEEGHTHSNVDNTNYSNKEDGSFIDEYYYSPSSYAIEQIMGNLEKAIVEIENTQIAYFRNSNLLTYIDDYMLTLQIFNRISDYNDAYKIENLLEDEEYSFIIDKACKNVNNNDDDTFLGSYPSEDNKIGIIITELEKCKKNYSDEELLHLFEETKLLEKYRKFYHDHFVNINNIFNKFISLNLFNVETKHKNVYERYFNLFNLNFSNVEISFDLLLKRFYKILRLSKTYENLIIERDKKIQDINNAQINLYNDKQGLQTNVELITKEKEYLEKLIIKKENNVKEISEKYFQLEKEYNEYKNNNSLILEQYENIKNQNYNLEQELSKKELKNNTLNEKNCEIINLYEKEKACLQTLLHESKDVNMYLKEKMETLLNNNERMKYDYDIRLNNLNALWMEEKENNKKSNFNVNSLKKENSNLLIKINEMQSKNQLLKVELSERIKQINMFKTSINSQKNNKDISSTVGYTLNSGINNGSISDDLSGKIEKKRITHGDYLIDVDQNCNYFLNIDVTACKIEYEEKIKKLEENITDLNTEILKLKGEKEILLIAIETWRSFSVDSKDEIKHLKKMCNEQIEKHKEFILINKTNEDKLKFVKNLLMCEKDKYEKDVDNIKEKLTNELETVSNELKEKTLEIEKLKLTNEKLLLKAQIIDNGKNDEMNMKKKEEEYIELLKKEKENVEKKFENTSEKYNEQINLNKKLTDDINLLISTHKEQVKVLNEQINILKKDNKYLSENLEKEVEISDNNLIIKNRLEQLVEINKDLYKEVQENYNNTEKMKFKIIELKENIRVQKETHLQQQKCIIELRTKLIDNNMASQKDEYVSNLKMNLESSRMQLKDLCDQLEKGNLNEKKCNMKIQMLETKLIKEEKERKRYQIELANKNSTDSISYNKLKTQVEMVTEENKILLLRKECYEKEIEQLKRDSQFFNSTKNNDINIIERDVLKKQVEEHITKINEKDKQIVNLNFEIKKLYNQLEEMKERMNRIETTTPILDGPTDEASTLNIDNSKTSQNNQLSLEIYKYINENIDLTAELENKNDVIEQMKEDIKNKNKEIAKLNKDVINLSTNYDKLKESIYMMEKHKTNLNEYIKQKDEIISLLQQKGNNNNNSPTKFCNLVENNNTNKNGANEDDFDSPIKYNINLKNNNSKEIEEKIMGMEEIMNTSCEEVINTLKKIPQTNVENDDNNNLNSSKNQEFSVNSDHITLIKCNILKMFKLGSCYLYIINRNLKEIKILKDKIHSFEENIQSLNLFINNLKDQHKNNEMIKINNEEQIVELKNNLKNNENCINNLNDNLKQKDEMNNSNIQNLIKYKSFIINLVYQSNIFFHIFKNINKQKVIQNSIFNQLTQLRKELDFYLNDSIMISELENKEKSNLNNFENNLLNIVSTFSCENYEHIQIFTNKFNLIIERGQFSILADSKIHPSQNEKQSENQNEKQNEKQSENLSEKQNENLSEKQNEKSNNFLSNISSYFQSSNKYNNAPTFKELNENTTEPQKDTQIQTVQISQEKQNEEENTKNENIIDTQVNNENYQIDALKNEEYNDDQMYSVEDDGSEEEEYRFNEEHAEVEIDGKQAEVETDGKHGEVEIDGEQAEVETDRKHGEVGEHDEDMLNDSKEKESSNIESYNEYNSNREEYVDVSDNDEEKEGDEFNYSNKEKSSIDNNYDESNCDKSNCEENETLQRYEENVIVENGNNLGEKELLTSNVESNLFENDDNNNDDNNDDNNGDNGNNIVSEVGEENKLLGDNSVNHINYENIKTDVAVNVDIDANTSNLQNEENISPSAFSNKLENQNNTFVNDSTRSYLSECEFNSFDKNDNLKIKESKKRKYHSDTEIVKQNNNNKVEYTKKKMRKMNNSHKFTSRGTSDVTVESPTPQNLSEKLSEKLSEKLNGNINGNINGDDNENEDDENYASESFDNYYDEKKKYEILENISKLNQACNNNNLDATIDGNNYAKKNEHNFLMKNDKESQNENAKESDSCYVISSDDDNRQIQDFEEDEEDEEDEEDEEDEEDEEDEQDEADEYDEYDDVENDDEYDEEYEEEEDDGEMDEADYDQFDSKGELNSSIDDDSNSDDADKDMIDYDDIDNINENQNEEDSEVENEDDNNFLDEKNKNKDPVISIATSDDGQDDGQNDGGNEDQNETYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLX2</accession>
    <name>V7PLX2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_03182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLX2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764206" evidence="3">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB59792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="277" mass="31805" checksum="C6D244C17C1F2BC0" modified="2014-02-19" version="1">MRAFIFIINCLILGNLKNVQSTNDSNNKNNIGVSEEALSKLMEMKKLELDILKDFVKKDTEHSDIYKKFHCISSDYISFDKKEGKDGQTNEGKSGNKSEQETKGSSFIDKITSFIGIFNYNKINNIYSEKIHRMHNNIQEENNVPNEHTNDKTEFIENHEITKNEKPNSYMELSTGGSSSKGLFSSDKERANENYKVGNLGSFYMIFGASNIDYPWACTCDPLQLIEYKEKKRSYVLCSNQVDMSIQNSDLYCNPKNSSHYFYLSYILILIIIIISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLX4</accession>
    <name>V7PLX4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_02713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLX4"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004765417" description="Triosephosphate isomerase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB60429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="247" mass="28985" checksum="A07824A690015BDE" modified="2014-02-19" version="1">MLKLFWGICIFLMTIECMKYNYKNSNNLFNNHKINKKPFFIKSRLPLDKIKDNHTYDIKTWTKLGIKRYTNKKNNEVYSFINNKNINLETEIGRKKIIIANWKCYLLKEKAYKLIDKLTQIKFSNYIDVIVSPNLLFLPYLHEKIKKNDSKIFPCSQDVSLVNGLGAFTGETTASLLREFGINYTIIGHSERKKSFFNVGENIEQTALKVYNAINSKLKVILCVGENYTSRECSFPFQKFRELLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM82</accession>
    <name>V7PM82_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM82"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="462" mass="54690" checksum="6BEB04BDBF5D625B" modified="2014-02-19" version="1">MGVPVEEEKNVSQKDGAKTEKIETDEDNISKGFKDKIHEYNRSALHIMNTTKVSNKYEDKFDKILNFYYDDLLEKEKNKNERETNNSIILKEVNKETLLNFNDLKDEITQKKSEPTGETITKYVNTLLKDGEMVLKLNTNKFFNRMFKLIVREKLMYTVCYNEKISKNGRTTKNEEEISENVSTDGSNNRKMSNKQCGENCFLSRFRKEIIYKEEDIYNYYVSLEKLFKKSEIYMKTDMISKYFKFYPTKKIIYNFENVINNNIFIESVRSILFDSYKNDEKSIYTSFAVVVDSLFSLIREEAIIEDMRVYIERFFKDISLLNKNVLTFLKTELFNEATPYQVPNLTKKNFEHILVKIYLRSVLENILNKKISHRIGNKEIRLKFSFIDNSETIDSGDLDKIVMEENLPSNPSEQDVLCKFIPIKKRLIYDKLNNTLKIAENAVLDYLFKMLLQKIHKFATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM94</accession>
    <name>V7PM94_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM94"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="169" mass="20858" checksum="AFED60FCA44B0617" modified="2014-02-19" version="1">MKIIEYKQFKIYKIIQNYKNTHNIFSQQNVLYKFIEYIPKDKSDCEDKLIQPKNYIFYYLKKSIFFLQNYKYLHLKRILNCLFVRNNIIDIRTIKYLTQSKVIQFKKDVNSCLLEAYNSFNYKNKKELLYIYFKLYSNICFFFQSKNIFFFHFLTNVLIVSWVYAPCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPA7</accession>
    <name>V7PPA7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPA7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="138" mass="16382" checksum="05ADB5BD920EB961" modified="2014-02-19" version="1">MVKYPNIMYPTPKHYFLLKKYNLQHINKSFSKEDVFSMLFKSVKPILYKDILNCLQHENCNNKIESECKETVLAYSDEDILKIYKKFIKSILTPIGAKNIELVFTEMYNFTDLSHYFSCMNKLPPKSTIVDDYIKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPB7</accession>
    <name>V7PPB7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPB7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="946" mass="113926" checksum="F64931DFD371109B" modified="2014-02-19" version="1">MFSFNIYFKKCLGVKSEIKYQKWCRYYNTGEYSSNVSRIFNNINDKLKKKNNKSIEYEKCDKVVIKDIKDIYKQYESVIKKINFSKMMGRDLSYCMNILSKINYFKEHIFWIKCANRLIKGFMIHRINTQSYYIISNALSKGTVLYDKDINIGDEVSKFEEIENGKMEKKIKNIIEGPKFCRINFDGTVKLNKREDKTNLDKKNNSNIKKYHKIYEEISIRFLYDVKRMNIDEISCILNLFSKLNLNEYNLLSYYFSDYFVMSFLKNKINFEKYTNLCYSEINREDVEKKPNICFVEKYDISKLIIILHSLVNSHVTHVEFLYICCYYFNKNFEYLNNIDICNILYSFGKNSDWLLRKKYRKYIFLKRITDKQYVSYIKNIVEGIKEYGQFYNNNNKKDGSENLCYIEKLYFNNEKIDIGNSLCSINKIYEKGEIYYSSLLTKILKHIQKEKVLNKFSCIQISSIVLSLIKLKINSLNIFHSFNYKVIEMWKEFSLRCIADYLYSKYEINLSNDYVLFLLFYKFVQIIFHKYMEEFEKIYPKHDNHINSIKQSKEGIYFFQKNYKKIKILNTRDSLLIVRIFQSFSKGDTKNSLLNDQNFKSCYDYLYCLEYVFMLYKNKENERQLKGSVFIENKFNTNDDDDDNRNNKGEYFWRELESTNNSSIPLLNNFDKKYEAVKRLTFRTLCLSLFQHLDNFSFEYKCLISYFSINISDYFYLVNYEGDEKKLNDHFLFCENSKKKKDSSYYINKNVKMNHCHKEKVPYFEVSRLCRSFSSRMLFHVLNEMKCETLNEVTLRQIYTCILCLYLNIINIWDIAKIKLKNDKKKYLLLLGNVILQEECKSDLKYLNFYKKNINTILMNTNKMPDFTIFHFISLNILKKIAIFLDKAMEKNYQQNEISISSKMHNDISNFLRTFISNMNEKREKKIKQRNEIVVGPFVLDCILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPC2</accession>
    <name>V7PPC2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_01369</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPC2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="30"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB61481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="873" mass="103641" checksum="4588F800EEC90285" modified="2014-02-19" version="1">MHNIYIYIYIYIYYNVINNVDNNLYIFFRVGNCIGARNYKYFIYFIFNLYILICITLAASIYKLTICMTALSNKGYNSEKIFIHIWSLATDSIILIIYTVLTLWFVIGLLCYHIYTIVTNQTTYEQIKTFYQNDNPFNIGVLNNIKEILFTKVRPSYINFENPKLQVIDQYSSHNIITYSDKSISIDQGIANISLPVSIDDKESNIIKDDIIDDDIHYEIEMKTDSQLLKNHDDEFIEKNKNLTNKNAFLSTERKSLKRVKEYNSLNSLGIDTESKSNNFKNKRISKKKTEDVDSPKINIISNRGIGKTVRSKDYKNKIITKISKIKLIKTIKKNLSEELNNDIEINNYQDKCIIDVNNNLGSLYIKNDVSSGSKTNNEVFSDIDNELDGTYYYSSRANNLADINKRTNEKKKKKQNKKYYIISIKNWEKNNTTTKIVENDKDYYNDNNNNDIYNMNTHKEKMIETNKIHENIHESKNNHYNNITRVRRKVEYKLLFKKKFPFILKHKNKIQTFYMIRDPKTENKSIHPYSTGNIEHENPSEILCMDNISIEDNEKEFKKINYFKKKNYHKIHQSNYSETNTNKLKNVISEKYSNSDFLNDINCNKYDDTNISNCNVKHGNLGKRESKESNKKLNRKRKEESIIDIRKNVVLCIYNYNTKGNSGKLPDKEKKITNLEKKNNLECKNVIYNIRDKKEKLITLLKYKRKGKKKHDSKISLAYLSQINNMDFDNFSQIYKRRYTKIYQWKCKKIQQEIIRRKKIKLLSRSSHKNIHTYYNNNKYFLENLNNLTDFQINNNELIKRYYQHDSLYSTAIKYNQFDNVKLYSYLTHMKNAQNRSDIKKKSKASKFFDLFTTFALIINCINIPSNNDNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPC5</accession>
    <name>V7PPC5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_02175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPC5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB60825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="361" mass="42478" checksum="87BF78A51E780107" modified="2014-02-19" version="1">MKEIKIVPMKWSGNGLLGININYERFNALYEGVKILKTFNNSSDFESNLMENSDYIIGHENNIIRNKKELTEYLDNTINIKSKDDLCKSQMYIYNSNTEKVRKIIINLYEIWENIEFLEGNIKSKHLQAIPICNKEHLNNITEENNFKEIFFPQKNELEKHEHGNDECSTEYDKGIVKNKKEEQINHFSSRNVAALSINSEYNNDNNIINFNKPEQMNNEYVCSKDNNTKNSLLPENTNEVTELDNLCYTNQQINMFVNVKNDNKNSYDENSTIDIEKDEIKRCGIANSEEDFNNTSDSSEWSDKRKNTYSEYVKNMKIYTDEMTEIYESMRRNNEILNNIKQMKKVETSLDGYNEFIGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPC6</accession>
    <name>V7PPC6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPC6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="36493" checksum="D469D11384FEA1C4" modified="2014-02-19" version="1">MLGKRKVDNTQAQKKKKKWVEELDSDSEDIDLDYLNNLDENDKIQLEEVSDKEDELLDQLEKEENKENKDGSQNMEDTINDGNDNKNKKRRYDWMSSDDEDIPSDDEEEDIEENDNIEDSDNNIENQKYKNGKEENNNDIKNNYSNPIDVHKKEINKIGDINDIENSTNEIIENINKYSIDQIDIKFEEIEHIVTYVYFHNIHFDCMTENLVTFLENHTKNKIIQINSDKSTNHAIIYKYDEKNDEKVVINKFSHYGKLFVHVKNYQDVLRLLKLNETQFMGRIIKSAQAYRKKNCFFTLQTPSHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQA3</accession>
    <name>V7PQA3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted ookinete protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQA3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="16026" checksum="3BF52B82BA41E750" modified="2014-02-19" version="1">MKYFFVSIYLFFCCFFYNNFVLNEKIIPISPAGRNKLKKNIEHDDDFKINIHAPVEDTQEVLESLDSLMRVEEIQRKVDEEEFMNTKQRLLKVHKKRIQDILASAFEPLHDFLPNPLQYLITKDVHSYLKSLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQA8</accession>
    <name>V7PQA8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deubiquitinating enzyme MINDY-3/4 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_01901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQA8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF8">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Deubiquitinating enzyme MINDY-3/4 conserved" evidence="4">
        <location>
            <begin position="226"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB60942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="807" mass="95769" checksum="61CDB964D8AC3285" modified="2014-02-19" version="1">MQTNEELLRKEEEEISKTIALSLEEYHASQQRNKQSNLDIDDENDELLQEAIRLSILKCDTKNTEKEKSDLNDSYYDIAKKNFDKITYYLCNNYETTKNKTDIIDNKLFWKEIYKDYKNIYIIIKDYINNLHKRNEKLNEGKKNSNYSSNDEYDSDENSSDCSSSSSLSCQSLEQIKKTYKNINYTTQDYCKWLKKGNRSKSLNDHVYVNYLLTEMKIFEDSNNLHDLVFGINNYKYSNKMDIQKWCNHNISFYDDKNINFGLRQFLSGPCGLISSIQAYIIIILLFNYKYNFLWENDYFNILKTNNDFMNMSFNNTDKNKLIEENKMNTTNFYKEDISKDSNNEKQNEDIQYDNTNDVHKNLDTKQVTQFKNIESSHNKERCSEKNDEEMNKKDNEILYLVREHIRDLKYYSLVESLAYILYQCTDKSYYIVAFLLPECYDLTYNLSKQNSNESIVRDIKKINMYYKEFNNIKDVIRFYLEHFIIFSSSTGVISFLYSVILTRGIDNIKDDMDDINHPLIGIYGHCSQELVNLLLTGRACSNVFDNTSIINTFLNNDVDIVSTYENGGNNNYSNPYFVGINNGNDSKNSQNIMDIQNSTSFNKNNIILKGINKRPLIGLLTDFEAFKYCEVGNFYKYPIYPIWVISSSNHYTVLFSLNIKNSRCTSEELYLEKLNKVWKKYDKEDNKYILSHFISRFIDDLNIKDEYRNMFQGFVNDLDILLYSEFKSFYLQVKQKDIDERKFADPPKDKYFYLYDAQEIPEKAITYFFLKGVDYDVSHDNNLKFFNTRWPNNSVEVLNKTKKMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRE0</accession>
    <name>V7PRE0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRE0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00164">
        <property type="entry name" value="S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050437">
        <property type="entry name" value="Ribos_protein_bS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF10">
        <property type="entry name" value="S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="616"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="783"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1072" mass="127513" checksum="98A5A480CE4CCC25" modified="2014-02-19" version="1">MIFTKQCLFLSFFVLIVSSFLKRKLVLNNYIYSKTNRFKKRKKIVNYQLVKSKDKDVESYIPHIYKDIAPSLKGLADQEYSYKQLLNAYIPETIEREKRDKLNKKSNQKNNKKQSKENRQTNKNNEIDEKEENEENECNKDLSNNIDKMMEIKMKENDIKHFENLSEISNHKKKNKILDIAYDVIEDTLKNTYMNQKLGLDNENNDSKKDYLEIAKKRKDLLYDKLINNYSMLNNSSTFDLFGVFYDNNNYKDDNKLIEELDKIMNLEPFKSNKDNIDEDIDALLKKDKIPTHIRNFILKYKNLRKINMSNNKIDHMKKNENEQVKESGSIKQMDNDGNVDDEKEKDEENRNYEKNIKDENGENIYNDFNRDLNKVLMTFNKNLTNEKLVKRDKYIIDELYEEYKKHIKNMNIKRNKLEPQKDNYDFLTFVHEYGEEFFFQKYGYFDNYLKENVEKIKNKVRSENANIVSIPNIMNSEPNSKQEKSSTITKSNDPVNNIGNEKDNIDEDFLNDSPEKKINKKNDEKNNTQMRNNLDWRKESNKLESYMLSNIVHEYNKRIYDIYKPNDMITNHYGFNNYIDNEEYDKDINVSLNKYSIMNYDSKEELNNDESLYVGKLIFGKIFKIEKNMALVDINYSHYGEIHSDQMPYNITNISDVFKVNDKLIFEIYKMYPNRIELTLKNIQKINDLNKILLYKTQDIPFEVTVLSIIKNGITVSYNDIYTFIHISAISSKYKVIVDENETIDSNLLNKKIKVFCTDINKLSFSNLLYEQNEQLKNINMYDVIDVEIIHISKYGLMVKYNDIVGLIHVSEISRKKIENINNVFKINEKIKGMLINIDYYNKRFSLSTKILETHDKNFIDNREDIYNNIEHIVNNIKKRSNKMEVNDSNIKNQLLSLIDIYKDGNGSEKVKTEEGKDETTNQHKKIQEEIKLYDNEKIDKHPQVTSEKTGSQTEHITDIKNDNNIIDGEEKYNVNSIDNDIKKMQEKYQNNDDDTLSELNQSEEKEELSIDVHNELVPYLLLKQSDSNKEEHEEEKKEIVWNLDDEEFLHSNSPTQNSQCMLRKLFKYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRE2</accession>
    <name>V7PRE2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperonin GroL, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_00776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRE2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB62151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="542" mass="58198" checksum="024D678BDAF9BE6E" modified="2014-02-19" version="1">MLIAFSFTKGCNKLADAVSVTLGPKGRNVIIEQSFGSPKITKDGVTVAKSIEFNKKLANLGAQMVKQVAANTNDKAGDGTTTATILARSIFQQGCKAVDSGMNPMDLLRGINKGVEKVLEYLNSIKKDVTTTEEIFNVASISANGDKNIGQLIADTMKKVGKEGTITVTEGKTLQHELEIVEGIKFDRGYISPYFINNSKDQKVELDKPYILIHEKKISSVKSLLPVLEHVLQNQSSLLVIAEDVDSDALATLIVNKLRLGLKICAVKAPGFGEHRKALIHDIAVMTGSKVITEEAGLKLDDPDVISYLGKAKSINVSKDNTLIMEGEGKKEEISERCESIRNAIKNNTSDYEKEKLQERLAKITGGVALIKVGGISEVEVNEIKDRIQDALCATKAAVEEGIVPGGGSALLFASKELDSVQTDNYDQRVGVNIIKDACKAPIKQIAENAGHEGSVVAGNILKEKNSNMGFNAQEGKYVNMIESGIIDPTKVVKTAISDAASIASLLTTTEVAIVDSKDGKSEEMPSHMNSVNPMGDMGGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRE4</accession>
    <name>V7PRE4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRE4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1206" mass="144792" checksum="9B11F119A56CA3B0" modified="2014-02-19" version="1">MNILNSKNRIITDLIKFERKIKCNVRLYNNKKTKCAGDNKKNNNFLKNICNKNVIRNLDSVNIIENLKYVTEYNVNEDIIKNYINRVKTLKEQWGLNKIYFIFKTLIKYKLYDVALLNKLENIINDIEVPNEDMKKEKIDCFENVYIIRISYILYSFYYFNHTNEQVVKKLISILNIKIDYIIYHNDYFNRFIFNTFKGFSERYENIKQENNNNSYGKDIDNVQKCINYDNKTCNESPEYGILGNSLKFNGLKKEIYEVKGMALDSNKNMDVYIRNITFNEIYFIISLLKKINYTNNKWFLNKLKFIYYFNCIDIERPNENDWRYATLLFHLIYEPYDKYLYNIMKLFLLRHNNISNIHDLVLIMMTIYYTGVNNNKTYNTNNIDCFKENINYINHQYEYTPTGIFDNIDSIFDQMHIISNEKTKKLKFILNYISEHRNEITNKDIPDIICERIFNLLNYEYYKSKSFCYNFESKNKEKQISNNIKSEQNEENNLEKNKSRNNSSDFYKTKSSDLQSISEFIKICNYMSKEVDVLYYLYLKNNIEFFNMETIINVMKMYIFVYNISNDLNKNYYKNKHRDLIYSNMITNNLNNLTNIIVQIIIMNSLHRLYSSCNLKNLANILYYLHQINSTFDNKTFEELHIKKLQDNIDDIVTKKLKVIINKQGENNTNVVEELQTTKERYHMNNLDAISFDDMEYGEKINETFAKKAYKNEDDNTHSEHLHNSLSKKNENINEGNNMNLKIQHDENNINTFISLFNIYSKNLNNKKIIYMLLQILNKYNIEQKSSKPEIYINLLNSFAKMKYRNLLLIETCLKKVTGNLNSLHFFDYINLLISLSRLNIFGINLNVYDDVSMSLKNKDAMLNKKTSYENEKLLFINECNDSNLKNCSQISMVNNLKCILEKINENLSNFIFTPSYKIINIIPNILNSYVILGFDKIHFKNINKMLESFHHYIFNYFEEKHSENINMSYYNNKYDIDSFNEYYSTDIINSMGSPGVKNHYWYFSEQNNVILTKTNSNISLHIPIHSIYQLYIFNVYFNIYIKYLYQYYINEDKYIPVETHSMNNNREINCIKNPLHYLNNSRIYINADKTKTDKKSYDFFKIHNILSEKSIHILNNIIYFVKYINNFYNKSTYEKYNFYMQFLIHTPEKETRNEQLVEYAKECHVIEKRNKSAIHSSSFHRDVFSTFRLLGINDMECEVILCEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRF2</accession>
    <name>V7PRF2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_01231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRF2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050808">
        <property type="entry name" value="Phage_Integrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30629">
        <property type="entry name" value="PROPHAGE INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30629:SF2">
        <property type="entry name" value="PROPHAGE INTEGRASE INTS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764351" description="Tyr recombinase domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="153"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="257"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB61317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="46831" checksum="CD26A85D537C3A81" modified="2014-02-19" version="1">MMKVVEVILFIFFVNHLISVKSFIANTNHIFDIINFKNDNNLISGKRKYFKNKNVSIKKNIIFLKDYEKAENDDIDDIGDDIDDDIDTENTSSSGSSEHEKTIKKNKIKNVGKKKKKRKKVSNVLKCKSCTKPLKPRAKFCVHCGSNVSVEKIKLKKYIEDIYLPLRKEEVSANTYRVERGFWNDILPKLGKYELHELGSNNWESFLKYLKSKNCSPRTMALYQSTYQQSLKYALYRDYLKSVHNFRKIKKSTIPRRKTIPLSPKEIELLLKNSGDMHRAIFATSIGIGLRPSEVLRILWEDINFEKKEIFIKGEKTKYSNTAIPLTNFAYNELIKWWEIEKKPSKGLCFYQETINNKFNYTNTKTPLKTFKTALKGAAKRAGIEISEDGKKRRIFPYLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRF6</accession>
    <name>V7PRF6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_01235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRF6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="374"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB61322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="652" mass="75695" checksum="4C206D2E72A21A56" modified="2014-02-19" version="1">MGNCMAFINYSKLKKKKNTFTNLDLYLEDAYDSDSSDPYKKKIRKNKINNNTNVNNSNGITTSNDINNSDDQECNHNTKGNIPLSYENNEIENSVQHDNNNNSENELNEKGTNDNNNTENDKNKQSCKSINSQTYSDSISCNCEMNKQNQLCDKNVTPTNITTIISPNVPKKKPKQNVLNIKYSNMLLSDIRDTDIIVTFLFSLFLYFNANNIVDMLDRNKRERYELKNPLNINHDVIKFPTFPKEIIDNFLKNDFTLLKKYIKNKCNKLKKKYKTNLENVNNEKDEKSGKKNFKYELKIKKEKCSFSKIVESVDRNESTYRDITEVLYDQNIPDIKITFVVMGAYCFYQKNMKPFQDKNTFFYKSPSYSCDAEISVACKKGRKLDCPNQDDFTIIQTNEWILIMVFDGHGPSGHDISNFSHVVLPLIFSYNIERIFENPVRTMKTIFYMINCYLVNYSYCINNNINPININFIDYNLSGTTCTIILYNFLTKKIYSAHTGDSRAVMGKHDAKTNTYRAYNITEDHKPSLKLEKDRIQAFGGEVKKLQGDVSYRVFVKNEMYPGLAMSRAIGDITSSFIGVTCEPTIKIFDKSDEDKFIIVATDGIWEFISSEECVQMVSRKRKKKVHVAMEEIIKESWRRWERIDTVDDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRG4</accession>
    <name>V7PRG4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clathrin adaptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRG4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="90800" checksum="B7D6F7C68269313F" modified="2014-02-19" version="1">MGVCKKKQQSAGSDEDKLLFKTCTESTEYLHLYFKELKNHLIKFKKIEELYNFCYLILADIKSPINSRITSLKAVSLSLIIEPKNIQHLINSEIVEYAYKLLKRNKEGINTKKSLSYFGKRSYEDIYTLVLEANYLFKTIQIIKIIKNSKEYKFIDNIFKKIRDNKIDFLDHDNFCNTELLNDIKKLKNKLLNVLDQEFIDNIQINDLHSEYTRLISNAKDNVINFLYNGLYSIYCETIDEIEDENLSIRVESYFSSIDIKSNKNINFDCGNKKEKPQLKGSLEELNNFILLNQTNLNTSNDDISDNKNNNVIEQDLTKNKEANKTVSFNIKNNNIEDSHENDDIIDKEEGGEAPANNIFNCEENKIMNNLNKSQNEFDINIIDEWNKLKGFKDVKNNGNEHVWNCIIKKSNFYKTKEDYINYNKFLQEKENGLKENTFGDLLEMNKYIDSKNENKNNEQYQESNNLINDKFTKKNSSNNTIINVHNNNINNDLHIKNKEHVINYDSKKKQNISTSSNNNTNLSYFNKYFTQYDNIFNVQEAILKNKSLLYSDDSLEIFMDQNYYDVKGLIKFIFKNKRQINFYDLDMQISNKILFPLKFKFVPYEKLLSAYSTKCYEMAVKCSRVYNGFPLIKISYRMQDMLRKNIEIRLPIAINKFMKKTKITREIFDKFWNNENFNTNKEEKIITKDDNMNNDMLIERACLGEALSICYIEDKICLCGCYSDNSSAMENYFVLVGIEVMKKKIKITCKSNNSTLSSAILFLIILMFKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRG5</accession>
    <name>V7PRG5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_01435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRG5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="10"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB61575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="301" mass="34278" checksum="B6C53071D88D14AC" modified="2014-02-19" version="1">MAIYILFSENYTIVSDGYGEKGIKKTFEDEFFICENLNVYNKSLHPNFNFSCFCLIDGHNGKNTANFLKKNLAQELSNSFTKIQETYDDTLPIPDHFIRIGVNSACKKIDENLSLEYPGCKDGATCVIILIKDDFAYITNIGDSFAYLCRYLNNAHRAIDLVDIHKPWVLSEKERIIKHGGTIENGRINDIIDVTRAFGDFPLKKYGLLCTGTFKKFKITSDDNFILLGTDGFFSFVDINHVTNEIVALSKKEERLVNVEKKKAVFDAKIICKNMVEHAIIDKKSQDNVTVILIKFLHTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSD6</accession>
    <name>V7PSD6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_01741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSD6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB61990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37533" checksum="EE659CB6FBAF4207" modified="2014-02-19" version="1">MNSIVYKKIKLNDDVIKKFEVLRAFKYKHAITRNISWSYDGELLLTSNKNDSITIYSLVEGSSYKTLQSKNCGVDVVRFLDNANEIIVCSTKSNNSEHKQFLRFWDIKENKYVKSLPQIGNICELNGISINTNKKLMLVNSDDCHVKLYYFNCDSPLIIYKSNFKRPVSCFDNEGLIFIASYGKKEIHFYDLLMYNRGEYNVVSLKNKIQHDEFITNLLFTPNNKEIIVSTSKSNHFKIDSITGKFICSYKYSDVIPKNKQNVHYNPRTTNNDFIEEDKNNNTTSNQSINIQNLYDNNTFQNRPYSLFVPTITPDGKYIMCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSE5</accession>
    <name>V7PSE5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein light chain Tctex-type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSE5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="11105" checksum="80776A01CA87B388" modified="2014-02-19" version="1">MENDTILETHNYVNEIYSIIDDVLKNKMYSNGEINKWSNIICEECMKYLYSKMLPLKYIISCYILKNSNAETSIQYSTYWGKDDSSDLSKYNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTI0</accession>
    <name>V7PTI0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_00552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTI0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB62929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="179" mass="20562" checksum="99511F494D6A2151" modified="2014-02-19" version="1">MSHIFQVAINSRKVTVTGKHGTLKKSFRHLPVDIRLNKLKKYIKVVMWFGVPDRLACIRTVCTHLKNMFTGVTKKFLYKMRLVHAHFPINSNIVNDNKLIEIRNYLGEKRVRFVKALPGVLIEKSPNVKDEIYVSGADIENVSLTAALIHQSVLCRNKDIRKFLDGIYVSEVTTVEKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTJ3</accession>
    <name>V7PTJ3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">YYC_00538</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTJ3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="360"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETB62911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="842" mass="99142" checksum="D292161FDE5A473F" modified="2014-02-19" version="1">MENNFFLDEPPKKQIFICSRTQSQLNQYFSELKKIEKKLSKENLPINMIIIGSRKHLCINEKIMKKCPNVNELNEACRSSKCKYKEGFTEMVLEKKKKKKKIFYESSSDSNSSKEENDEINNYILIKKLINTKNIDMNKIKEICRHDKIEICPYYMCKENIQNADIILLPYICILNEQIRNNLKINIKNNIIIFDESQNIIENINNANSIGISKSQIIFTKLVLKKYIQKYENSLNNNNVIMIKQIIIYCDLLLKYFTSINESVSNITRFMLLSKLDALNLNNISAFLNNSLFCRKFKIFAEVNINEYFKKSNKERPSIISAYVNTSSIYLLCEFTNKLIRSNKYDSIYINKNDDNGIYNNSDLEDDNQYNNKTETLNTNNNSNTGGSNSSCSSKRPGCSTDNNVEAEKKRKLQNNTNVIGTKNKNEPNNSNDDFSDLSEYLKYILENIKDMILKEKIEIISVSSCNNFQNITKDCNNIILIGGTLQPIEEFLLLFLSEKKNKIKLYFSDYIFKKSNIFVRIMPTNLLTFNSIDNTYKNRFDRSHLLNIALQIYILTLYVNYGNIVFFSSYTFLNEFMNFLYNEGKYILEKMKKKKFLFFEKKNDNNVLKNYMTNIINIKKQDNQMRIKNGCILFCVMNAKLSEGINFHDDFCRNILIVGIPFFKHEKNNTSTSNINKNNLVLNYYKEYSKDRSKKNDPNTHDISNSIPILSDWQISQMCKTYELKCAMKIVNQCIGRSLRHINDFSSFFFLDQRFNNPEIYDCFPTFVKTHLNDIKNLGYTNNEIFQKEKQNFHEIYDDIKNHYKHIITNQDPIKDSQNYLKNFVTDLVHLKEFHKKMNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVL1</accession>
    <name>V7PVL1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVL1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="229" mass="27274" checksum="4EE15893BD00DB63" modified="2014-02-19" version="1">MFGAWLYFVTFRGGFFFDILKGNNVINENILAEWFYQILITLNFLEKRNIYHGNLNGYCIHFKDKTRKEIRLSLLSINNYYDNIDEKGDLYGLYCIRSPQEIKKLYHDKNNSWYVGMLLYFILHGSYPFINNNVLVNYHNIIQNNIPFAALKLDHKNYSNLMYDFLKSALEKDYDMRPSVEGLLNHPWIKKKGEHPIYEILDENTRRMGINQIKAIEQNLSTIHELNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVL4</accession>
    <name>V7PVL4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVL4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21017" checksum="0154150DB0B21C58" modified="2014-02-19" version="1">MRNASFALAKSVWAAGDFKGQIIEGIKRPVVTLSLSTNNVAGVKLPIFQVHIDPTVDVLGNLGVAAGGQVINNTRENYLQCLNMLVKLASMQVAFFSLDEEIKMTNRRVNALNNIVLPRLEGGINYIIKELDEIEREEFYRLKKIKEKKTENLNNSIEDHALPDNGGHKHVKITNNYANIQADDDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVM0</accession>
    <name>V7PVM0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVM0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB62198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="155" mass="18521" checksum="3C9346A79D104E84" modified="2014-02-19" version="1">MFSKKPQSENKDSTYIVKNLYSENELKKVTQDYLSEEIRNLNIYENVKYSNIRILLSIILIIIGGYCCIFVNHKNEPILMIQFLAAFFSISIILYIWEYFYFEDYFMIIETNDNKAVKLFLKFDIKTSCLILNYKLNKTVYSTPFELMKLYNEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVM4</accession>
    <name>V7PVM4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVM4"/>
    <dbReference type="OrthoDB" id="430309at2759"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB62687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="568" mass="62285" checksum="9992E41D70A33057" modified="2014-02-19" version="1">MIADPSMLWLVIASGVACFFMAFVTGANDIANTFSTSIGAKSLTIKKALLIAFFFEALGASLLGGTVTDSIRSKIINFEAFYNAPEFLMLGMFSALVGASLWLAIATCLGLPVSTTHSIVGALLGFGLSAGHADSIKWAKIQSIVISWFAAPLLAGSCSAIAFSTMRSLILRKKNSFEIIKKWYWILIFLITLPFSVFLVYQNPIVLNTKCRMKQGNKIVYASPCYLQDWSSGHVIYATLISITLSLLLTGIGSVFIYIVYNKRLKCYNFRKRLFEDQYMNDIEQNVKPNTTCNGNNSSLNSVASNETQIPRLRDQTNKGNNDNNEQIEVSKGELNNKSGTKNDIEQNVIETFDQDTEIVFATLQIISAILGVIAQSANDTANAIGPFAAVFNTYNSGIREKIKVQWYILLFGGLSMSLGLSILGYRVIKTVGMKLIKITPSRGFTIELISGLVVLFFSICGIPLSSTHCAVSSVIGLGLVEARIFENDKNGNTDKDVSNGQSNANNVAVKKRSLCPFSYLNTSCVNLKLFRTIFLSWIITVSFSASVTAAIFSFAAYTPSYRKDNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVN1</accession>
    <name>V7PVN1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVN1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15908" checksum="84A3E30DD5D71C52" modified="2014-02-19" version="1">MLRKKTISWDEVTINEQDKERGSRMKILEPNTPFNFIVMDSASEDETSKIGDSKTNSEGQDNIADDLINKLNQLVEKQDSKGVSNIDFKEKRKKHYNEYKILQKLRKSGTFDEIDEEYKLENNESNGDNNNDQDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PW08</accession>
    <name>V7PW08_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_00141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PW08"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052298">
        <property type="entry name" value="ZMYND10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244:SF7">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764501" description="MYND-type domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="407"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB63320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="447" mass="53652" checksum="E675C6C8817B8883" modified="2014-02-19" version="1">MFHVFFFLFFLRWFECHKNVVLINVYLHNNNELIDVVGDDKMSHILTKFEVLLRELITTYFIRFLNFEEKIKKNNKKTLQIDELKNKNIDTENSHNHIYDYISLYHEMAVLNIFELILLSDHIYEQIDTYIINLFAYIYSNLVSFLKTSSDEYFVKPITELPISEILKEENDKTHNIDRLKIYINVINTLRNIIDRIHLLNNTIVNKIVDYDILLILIPLIEKKPWKHDNYIFEQNEWIKNEDNAMATVEKQLWIILYTLILNSICQEKYEMTNYRRNNILKLRKYMNENLYEQLPPMKTLHTFIEHLYISKSVFPENKNSYLIIDVVPEIFDEIKNDILKNKKQVLSMLNNITISKEVLGSISEVYLSVYEFDHQIKKSKKKTKEINPIDTNHGEKEKPIDNQYTCNSCKEMAELQCSQCKQAYYCSKECQMKDWFSHREVCSSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PW09</accession>
    <name>V7PW09_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TKL protein kinase, variant 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">TKL protein kinase, variant 5</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">TKL protein kinase, variant 6</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">TKL protein kinase, variant 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_00928</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PW09"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="301"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB62332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB62333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB62334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB62335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="440" mass="51626" checksum="D51868682308D136" modified="2014-02-19" version="1">MNVRQYKISNNNIIKEKKINKQETKDNVTNQIEQVKNLPYERTETIAYDSNNENSKIQTNKKIWNNEDGDSSIHRTNYGLEKKKTYNDDIWNSYERLPTTHFLNNSIEDSNLNNNIDYDSYNKQDTNVYNTTFFDKTKSEIYLNTNGNQTLTNDGIEKKTVHTCNNVKDTKNTLNLMNKNKNKNPILTDKESKCNKMPIRNDQNNYEKVSTQNKNDHIKKMKIFNNLNSITKPISNIQKGSESRNDKSNESNVKKIIKPYDKPTTEVNKPICNGVTIFFKGDRRFFNFNIPQNEMIEKKDLEIMEFISEGSFGAIYKAMWNNQIIALKKFNTSMTLEGMRSIAREINAYRSISHKYIVKYYGVCIDSDFIGIILEYFSKGKIFDTLHKGGFNLTYELRLRMCTQLAEVMNYLHEDKKLVHRDLKTSNILFDDEVIRNIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWL0</accession>
    <name>V7PWL0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWL0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1155" mass="138791" checksum="222A3F98A6731257" modified="2014-02-19" version="1">MLKEKLLKLLNYYYFLKNYYIYHILFVYTFFLRITYTYAEITISHFFTFLLNKYDNIDTNDNDGNLFYYFTHFFNFNNKSDDKFLNTKLFVVVYLPICLKCFYTLFFDYISYYIYMYYYFDKINDFKKVYYSSIPYELSKLHQNECIYVDRDKNGKGNRRESKKLKKNPITPKKKIRAYIISKRKKISQNDFLNKLNDIPFERYKIYLLKKKINDLLSGKRKSVLTIGRHNTNEMMNPLSGREYEKEQKRCMKIKIEKCDDKHIRGVLNGNSNTRGIVKKNVFYNLKKKKQKKYNNSNGEDLLKNSQFKKKHKISILEKVYMKMKKYYNGERTGGEYVSLTNEGDNDSINHSNNKNEYSDNSFAPKYKNYIYKENVHNYRGKNNFLNFRLDRKKKASKNNDCYIKLEDTEKNSDVKYNVNGELKIPDMYCSSLNSQCSSKNKSKNINNFETYRFENNNNKLVNPIKNEDIANRHHLNNDNYYKDDFMEKVNKDNNGKVKFDECERENDEKTNEKRRNSNKSLKGSLKIDYLFKDSNELTESYIKSNEDNNDYEYYYYYYYNKFKSFRYGSEDNNSSIREIINNKINEEYYHLKLNILILSCIIIQVFNSFILILISSNFIRKKEYIYIFCFLYSLLESVTDVISDNIFFLCGKFTNIYRTEFSLNTIYVIQVISKMILSISTIFIYFVYHIFFILYEHVNIMIINTFIKALSIFVLSFIFLKNKDKILKHSQNEYIINANFDEIKDELDNNDNKTKSVNSFSKKSSVSSKSTFEYGVLEGEKQNSYRTLRRNNEENIWPEDDETTKKKNEYNFDHVNKNNWESYYNNGIKNYTIPSFRNNIFEGGELNIDDLLTHTIYNENDEENMYVYSIFYKLKKIVIDNVNYIKSGCCKLKDIATRGQKIYHLNSKDDYTLLTIMPSKYEEEIYHKKYHMDYKTNNNKKTSIIENIKNAFKNKAFNCYPSFKNSFIEKYNSLIEKDMKIIEQEKKNIKNRNGNNILNKLYSDDTIQSENDNNFTYTKQNKSQIKHHKKKKIFTYPIKLLLNNLNFSNIFYICLLLIIPTFERIFLNYKIKNIHLDMRSYCYLNFAGYVTDLVGLYIYISYFNEDSYTSSIFISSIINISLLSLRFILFQNKFNQLWLLVRISQLCFHCIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWM3</accession>
    <name>V7PWM3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_00619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWM3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB63017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="210" mass="24647" checksum="84169F4282143309" modified="2014-02-19" version="1">MVQLGELLSNIPLITRVYLILSSILMVLCSLDIISPLSLYLNWNLVLNEHQYWRLITCFLYFGSFGLHFFWDIYVLIYYCSSLEDVTFRNNSADFLWMIIVSCFMLLMVSYLFGGIYFYSSCIINVITYVWSKNNSSTRLTIFFFTIKASYLPWVLTILSLIVDYNSSDNFFGILVGHIYFFFTSVFPLMPIAKNTQIFKTPYLLLVYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXR3</accession>
    <name>V7PXR3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXR3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="134" mass="15617" checksum="B804D9FBE8F618E5" modified="2014-02-19" version="1">MKYTAFKNSLRFASKFCQNNNYKLYMNSVPQFSTYAYGKYLKTNPLTNRLDDLLKKNSNLISIISLNGLDDLITQSSKIESVSIADWLLNLVEEYQSIHFILCNYNMISLCIHSYYSLNFVPPFLFFIVTTKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PZ14</accession>
    <name>V7PZ14_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PZ14"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="150" mass="17733" checksum="4132277D5464FB9C" modified="2014-02-19" version="1">MKYTAFKNSLRFASKFCQNNNYKLYMNSVPQFSTYAYGKYLKTNPLTNRLDDLLKKNSNLISIISLNGLDDLITQSSKIESVSIADWLLNLVEEYQSQERCVHIMSVYNIFYNYIFQKTIHFILCNYNMISLCIHSYYSLNFVPPFLFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PZ28</accession>
    <name>V7PZ28_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PZ28"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="119" mass="13946" checksum="2C7F217F63B65FC6" modified="2014-02-19" version="1">MKYTAFKNSLRFASKFCQNNNYKLYMNSVPQFSTYAYGKYLKTNPLTNRLDDLLKKNSNLISIISLNGLDDLITQSSKIESVSIADWLLNLVEEYQCMIKLHHNAIMRKYDHNTQLVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>V7P9M0</accession>
    <name>V7P9M0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_05686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7P9M0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB56231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="200" mass="24017" checksum="A333CC1B10219172" modified="2014-02-19" version="1">MHLKNHNMSNNNLATKHAPIYMHFIYFENFSLQLYLFDSVNYEAYYGIVSELKAILIYYLWEDKEIYNNFTKKIYRDNFFYLYYIYIIRKLKNENLEKCKTFGLDNHNFNIKRLKEILNILDSILCDDTGPQKEDSVCYFHSICFSILSIFYSIPSKFNSELLDTLMSKPNLINFVKNLNSIYNVWKNEKSFLLGVREIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7P9N9</accession>
    <name>V7P9N9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spen paralogue and orthologue SPOC C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_05704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7P9N9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spen paralogue and orthologue SPOC C-terminal" evidence="3">
        <location>
            <begin position="119"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB56256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="358" mass="41753" checksum="A99ACE742FD7E10D" modified="2014-02-19" version="1">MRMGNFNDNPNLNNINNDAELNKLLREYENKKDSNNNEVENIIQTLINGITHKTPRVKLFLCDHLRKCVQHVFNRPCINIPNNNNIANNNNITNLNNNPMSNLQNYKNINEFEKKKIYNNNNTILWRGILEMKNKDSLNINAYGLNGDVNNFLNNNIKNITISHRKKMKNLPKIEAIYYFEIQNEKDINIFESYKNYFNNKDRVGLASANENWHFYIIFPGTPIFNEIINANNNIQISFNNTFIGVVSYNPQILEMNIPRKLNPSQDDAPIINMPPTSNNSIYNNNNYNNNNNNNNYNNNNNNYNNNNLASNLNNIEEHKKSESEINTNDQTENDDNKNELPNWLNQFSSLAAYLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDA2</accession>
    <name>V7PDA2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDA2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="25571" checksum="3D9A049ED4887B53" modified="2014-02-19" version="1">MNNVLFLYLSLFSYFCVASLCYQMIYVNFFDENKKNDLENISCYWQYFCHGNFHFCQYGCSLKKKLKKGYNLLNTNSLQENCFINIECDDYDIYFDSEDPSYIFFFSNTYFRITSDSTLYVNLYKGNQNKRNGPNKQTGKTQSSVKKDDYHKWNTKKKKKYTNVKIINKLKNFVSQRFKKELIKLLIFFIIIYLIFLLLFIYTYLQRKQCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDA3</accession>
    <name>V7PDA3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_04410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF7">
        <property type="entry name" value="PROTEASOMAL ATPASE-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="917"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1284"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="918"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB57541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1454" mass="168491" checksum="93D3F15F61E8AEFC" modified="2014-02-19" version="1">MKNNMNIPNNINNNMNNNYNNENYNNVNNNSRNLINNNLNIPAGLNNMANNMNDRSNNMKNFPNGVNGLNKNIGNINNINKMHNPIGKMHGHINNIPNNMGTMNSNLKHGVQNIINGMPTGINNMHSNLNNIPDNIKNMANAMKPMPNNINDIRVNANYSMNNMNTNVNPNNNVNIPNDMKHMIRVNNSDITSNVKFNTMMNNNNNSHFVSPDNSNRNMFYVNDMKNVDNNVINMHNKRNNNAKEKKNNIPQFREKEYLENVGHRDKYLLNKNETDKIYLQNKQLNNMNQGNIPNINNNNTRNNNTGGISRMINNNAQNTININSNNNINSVTNIGNNNDNNNNNNILQRNMKNLENGGMHNPLNINQMNAMNLNKTFNFSSNDPHNFNINSAADNKMSNKFKDSNYNNINKNINIPFNEESKYDPYNLGNNINRNNGNNGIVVEKNMNNAEHSFSKQHNNGMFDIKAHSGKDNFGGIKNMNDDKNIRYNSKLNEMNNANKVGKDIINLSASNIQKLNEKNQKANGNSNTNFMGNNLPKSMENADLYKLQMNYDKLNSNDPNNYINKMDNYNDFIKENNKGKYISGNKYNANANTKGDQSKNKTQKMENELINKKFNPINNNNNNENAPNHHMNENMIYDEMKKMNNTSFEKMVGNDMFMFNGNRSLEKGINQMVNMQGFRDIKNIHNINNYRMANDNDPRSNEKNNNMFHNQRPNFEGCNGTENLKGTGNELEEKKRKKKREKKSEMEKNEKNEKKGLNRDENLDDKKTINQLIEHNSFMHNLNENNESSEVGQNIKNNLFNDISKNYMQGQNIGNDEKELNIDSNLNENMKKENYAYIRKQNIFENYENMNNLKNAFLEGDQNMLNNANIFNKINFKFQKKKSDDSYENASMFPNDQNDEDKKLMVLSRLFGNVIGENGNNNNNNNDDDNNMQTQNENNMNNSGKLPNIRKMNSNALELELYKNMPLDTMLNKLNLDKNILNILKDKINNINRNINVNICSTSMETPEEPIKMENIDLLKLINLFDEFLNWSENNLYQIKLQLYNIAFCLLLELYILILANKFSMLIDFKNKYLKNFEAYHPVIKFLSNCVSLNQIFEISILRFKEKNAKHIAYMNKLGKASLMHYLSVYGSIPLYNLIMTKIKIIEIDDANKNFNFFHEFISMNFLYNGNLNVPVQWNLPSIYFIKDVSETQNDDSIKCTKEKEENVYIPNENSDAYYYYKYIIKMQAENRLKVTKNRMPSMLYYCLNNCTDMTCAEISSFDGSLVATAHSNNIIKLWNIKKSQMNKIKEKQKDMEIYNNENVDEINNYSNIQENKPDSIHLDDQDENGIAKLYGNMYNISSLCFGETNKILLSGNLNGDIYLYSTISNRNYVKYSGGHTPIWSIDTAFLGYFFCTSEDDGNLRIYSTNKTYPLVTYKYNCTSNICKYHYNNTIVASGYYGIFFFTFAYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDB9</accession>
    <name>V7PDB9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Erythrocyte binding antigen 175 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">YYC_04322</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the apicomplexan parasites AMA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1740.170:FF:000001">
        <property type="entry name" value="Erythrocyte binding antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.170">
        <property type="entry name" value="Erythrocyte binding antigen 175 region VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003298">
        <property type="entry name" value="Apmem_Ag1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021620">
        <property type="entry name" value="EBA-175_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043057">
        <property type="entry name" value="EBA-175_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF0">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02430">
        <property type="entry name" value="AMA-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11556">
        <property type="entry name" value="EBA-175_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004763942" description="Erythrocyte binding antigen 175 C-terminal domain-containing protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="domain" description="Erythrocyte binding antigen 175 C-terminal" evidence="12">
        <location>
            <begin position="1251"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1061"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1114"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETB57424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1337" mass="155685" checksum="DF1FEDA48A92A60B" modified="2014-02-19" version="1">MKIYHNIFGFCIFISLWTPSIRAIDNPQEDFMDRFDILNNHVNIKWTNSGSLGQGNLKFDIYDEDNISSKLNSLENARLCPNNENGNIYRGSCPDYGKTFSMDLDKDEYSEDFLNEISLGLLNKKLLIDVEIPVNMSGLAMYQGLFANCPYDKNHVNDIKNEKEYDMCFDKFYSNKQNISTRIKKYPLISKYTYFGSHGLGGRLGSNTEYPLHIYNPIENYRTQKMRYPKLVETLEDCSIYSHCIGPCFDRDFDNKCFRDLPVAFNHKTKECIIIGTHEEKKTTNCNSDNSRNNGRCFSSIKKEKGKDWTYASSFLRPDYETKCPPRYPLNNSEFGYFNYNTGNCESPTKLYDNSVISFNECIEKLFNFNYANEDPGEKRNNYLWGVWVLGNKQNKLNSMNDLGVCALLREKPTCVLKKQNYYSFTNLTANYFDNNQNIEYPDIENVKIWKNRNSELSDNLKYNDKKFKNSDISKGMAINMNDINEIKENSKLQTNIHNETKKTKYGLYNYPITPISYLQIHHKMELKNYNMDSENSFTSFHNTNAPTHYEGNSKFSTGANNKRENTYGTQDINLNRNNNYNQPKNKPNPQAEYMDRFDIEKNHIYIDWKQDGKYGSDKLKYNIISHETADTIQSLLITNKDDICPNHYSPGRAQGSCPNYGKSVVVKAPGSINGDEYLNSNFLNEIHTGYLNRYMKSNVELPYEKSGLAMHHGDLSVCPKSWDEENMYKKNKDYNYDMCKSTVMKTAIPLKMFDYKTKKLLYFGLYGLGGRLGSNISRVKNIFKSQPNNITLPMFNPSSIKNLLDCSLYSYCLGPCLENAYNNKCFRNLPAYFNHETNECVILGTHEQERKNDCRTRRSDTDKPNCQNVRKNISTKNWTYVTSFIRPDYEEKCPPRYPLKFKSFGKYDEETGKCKSLINKKNIINIPLFSSCLEYMFIMYPSVLQRTEKKNYWGVWVASESVNSSNLYNAKGECYYINEKPNCVIDKVNHFSFTSLTTNDIDFNQNINLVKLDELVINNDQSSSHNRAKYNTPIENSESTIVRKHNSAPEHFRSLKINSYTPNRRGENFAKESDSTRNTDESKMDEVIRKREEAAKNAEIIRKFEEAQKAAWAKKAEEERKKAEAVKKAEEERKKAEAAKKAEEERKKAEAKAEEERKRIEAVKKAEEERKRIEAAKKAEEERKIIEEAKKAEEERIKAEAVKKEEEVIKKNSNLAETKISNNNYETRNIDDNSFKKLDEAEYTSRNIDNTRDKIISMSKENMCINDISSKYCDYMKDKISSGNCSNNERKQLCCSISDYCLNYFDYNSNKYYDCTKKEFSDPLYKCFSNEEYSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDC7</accession>
    <name>V7PDC7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sporozoite and liver stage asparagine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="888"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1360"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="888"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1368"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3180" mass="370304" checksum="E0B369BA471E7FE0" modified="2014-02-19" version="1">MRKGKPRHVPMFLRSENKKILFSFFSYFMSKNDIQFIFDHYDIGLIVLTKIHNIRKRYEEDKNNLQHENNKNDLEDTESIDEKVRAFFLNYKINSNEDISDHKKEKPEKNKKGKKGSVNKEKSNETNEKKFTAKNNYSIITRSKTEEIDPLKNDENDSPNSNNAHEENKPQNEDITNTNSYHNNNDNHSNNTSDILKQTGHINNADKSRVEGVKQESCETISESGESNTLDKKNINISTKEICKNVNNNNNTLNIDEEIIDKKNNLNDQNFENAEIKNKNNIKTCINETKIEDKNGQKEDKNIINKNKADNTILSKQVENNNTEQEYTKFQEDISMLIENNKNETCKNKLNSEERNNTNGETQKEKELDDILFPVRKKNETYKKFSKRINKTKTNEFINYHDDHCFYITDLCRKGTMLSLRKNEVLNKKNAKNAHSHHKFINSFGLNNSFQVIDDVQSLNNMYMNLKLFDGQLNGQINENNLNDLTNLLKSKNKAPFHINNSANNNISSNTNSYISSNDNFNIPSSYFIYDYTNTDKFAYTLNNVENLEHIHNYQNVHNNFYPTSPEYTSNNNINNTTFIRNSFNNKNDAVNFNINQNIDNCSNKSKTDIKDELNSTPIYSSNYQPTVTTFNNNKKTYIKTEKTKNNPKNGNTIKAQTDDNIIKQQDVKQNSYQNFYINQIKNEHITNTINSQNNIKNVNFHSNNIPLIKNMPNGCLFYQNDTFGNTIHNNSYNNDINAAISSATTSSIAIPTATNASISSPTSTTINIDQCYNQIFESNGIIHSNPISNNDSNNNMVDLNHIDHKAKNINMTWGDHNSKNTHNHPNLNIQTETTSINNDYYHTNNPDINENSSLHTDEENNLEDNNNMENASCLKKGINRKCYSNNSTINNNNNSDNNPENRNQNEYNDSCDGQNNYCQQNNNNDDNNYDKKYSATYIRSNNYSNGNIYDDINYETKQSEGIISKNQMKNNCFRDNNKFNPTDFKEVSPKSTSINNISNSMTSNDSSMNQYNNANSRCNNSVGNNNTDSNQFKQNINRYNNSNSIELKTNSQLNDYSSNSNTILLMDECDSNELLNPHSSDNNYLNDKDLLHSNNMTRNCSYNNDNRSNTFNELVNNMLFQNDGSPQSSKNVIKNYSTIYESQKNKLETVFPNVQNNNKYMRQNNIHQTNDTTRNGIEQFECIHNSDNYYINDNNVSNTSNVNDSKNINRGNNSEDFKTIKNEIKYPAINSETSNYVYNPQNNIMYIQNTSEQITKGNNNSYIQYNTTYSINNENISTNYLTMNSLINDQNKLENCSKNKNDVNDSKINSIYDEKNQKNWDNTSIPIKNKHENNIYEIKENDINSQKIELNDKTTQHFENTDKEGNENNSDNNGNPNFVNKNIENNENIANSIGKEQNYIFQENLQHLDTKNVKNNETYCLPSNEMCQVSQKQNNNIHVYDEKNIEENQTVMFQNNLQYNQAQPYYQPKTKGIYDDKTNFNPVQDTNDLQRNTNDLQRNTNDLQRNTNNIITNDPLIKNNYENKNPSFINSKQSVILPKNDDLDNSNFKGNNENNSKTKNINEFSLNKNYKNSINNSQKHQRDADINCYDINTKYKENLKKQKNSIVSTVDKSDYFDVENNEIHGKVDNDGYKGAEIDKQNNQEMNNNFCNRTKYIKVETITDSIDDKNNNSISSIRNNTNKTIYDIYMNDTMQLNENINNNKNLNIQNNSNDIITKDNNTNNLGNIDNNFTNSEYSQFHTNNSVKTQHNPELSQREMNYLYTNKMALIKDNINIDANDNIINLQNFNYINDQTNDNKNRKMNSLTMKMHSNASSYIFDNKTNNNSEEQKNNDFNLGLNPVKDKYDNLYANYYVNDNDHINSNDQQIKNSNLETQDTLNRRKKNTLKTISMEQLPFHNSVNNFENNYESNSSCYKYTKGINTTPMINENINNACINQEIYDNNRQNIETPRSKNYPVFNMGIQNNKANSEALDENGQIQSKNVLTNNLFKINKKYNSNNAETNNNLIYDNNENAQYNYLNDLHTNGRNSIYESHMDLPPNHPHLLYLNNLNAKNLENISERKISIPNEYINFNSLNHIYNVPQFDNLPNNVNSNTRYNNNNSNNSNICDNSINNTNNSIDPNNNNTPTVYNTEGPISNVDNNYNITNIPLDKSSIITNPHYSSNTNDNKNSAIYNNIRYSNRTFCNYNNIKGSNDNNIYIPNNNIKSYNDNIMHNLSNNVKGYNNSSVYTYRNNNIATNGKNNKEPNKGNNNLYNFNNYKNYIHNDSSNLINVKSEHPEKFNYENNLLDNVDKTNKNNINRQIDNEELNSLITEAHMRSFDNFKASEENSMRNNINNRFINNNNNDHYQMMINNINLYNAYKYLYRNNNKYIYNTNNNDKSSNNINIYSDINNFPQKRINTYTPNNLLTSQNNNVFNTHDNMHQDQTNPIILYNNINGTKNSLISHIKSDIPSSGCDTNQSNNDMKNENGFNYLYNGIPFDYFKNDMAFIYNNNIRNTGNIIEGTNIINDHNKQFENNDERMKENRNNNMYANLNNPSNNTIICKDPKNYYIKNNFDILNNIDNSNDIKNENNINNSNTIINSSVDLQNNKTKNKDNPNYNVNNCNENNNNADLKYIHELNKFYNSKGTSYKKINDRINDTMNNINMTSNMNTTETLGSNVDDTYKSISNISTTRNRNSNFNMMNDNQYIQLQDVAYKISDNYDNSVNKEDTESCPKKPSNLRNTNLIDSMNMMYLNKANKNIYNHPYYKNGIDENYFNSNMNISLQSEFSDPNNIIHNNLKKIKTNKPYNQSYPSNLPYNRNSNYSNNNINEISQINEGKNRDTANNYYIPPYMNPNDQAPDFKDNYLNTCKNNIDIDNINYYKAQQYYTNNKFINVNYDKNIYTNEPNKYSKNYPNEGFRENIDGTYNYNLGMQNEHHNPNYPLNILNNNNLYNNYVYLNMLNNAYNTNNNNLKLHNLEENNKLILYNNKKDTYTDFNNSNHNVNNPNDLFQLKIMDPNENRIMNPLNNIQIPIKNYYNLQLLLNYLRGRQVQQSFNHSASNTNNNNNLRSDTKRNYSISSVGFSNRSKRWTICPSYICCNSALCRFKLTCNFKFLQFNHSNYSFNIPYAIYNCYKNLMNFYNYFTSTLCPQQTYLSKHSTQVCYIYAYHTTICCFHINASFTIIYFTYKYYVIVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDE2</accession>
    <name>V7PDE2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LMBR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_05154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDE2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31652">
        <property type="entry name" value="LIMR FAMILY PROTEIN DDB_G0283707-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31652:SF0">
        <property type="entry name" value="LIMR FAMILY PROTEIN DDB_G0283707-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB56772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="54698" checksum="995B2D20D88C074C" modified="2014-02-19" version="1">MDEYILLIFFIGCLILAGITGFRLLIICGHKNDNKIFVHKIMNFIIIIGYMICWILVLLFPIDIYFKLSTNVKKYLNIFIVYRILYLICLSYIFILTPILIIIYLNVNNNFQICDQNNLINIENEEIFKKKTIEEDYKMKGNYKMKENFKPIIKKWCKIFFIKIVPITFFFICLGFFLFFLTYLPFKKIKIKLNANDCKLWYQYILDTNKKYFLKYNIKKIEECQNIPTDMNIKMNINLNVNDHIILFTFLFGFILFSFYLGIGMFTFPFNLIYLYKNKKRKIKNNQLKDELTIINIKAKKLIQITEILEKNKIQIKKMNFFKSFYYHIKYIRQKKILNYIVHRLEKDYQNILDSYNNPNNQIYAFGYLLFGLIFLLLTISIIVHLIFYNIFNAIIEHNFLFSIYVFWDSLLQYLIINDYIVCSIIVYTLIVSYLLICALSGYIYFSTKVCQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFB0</accession>
    <name>V7PFB0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="801"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="871"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="801"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="871"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="772"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1065"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1462"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1826"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1325"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="772"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1462"/>
            <end position="1477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB58246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1912" mass="221716" checksum="F1BDE2D2E1D2B21F" modified="2014-02-19" version="1">MEVATEGGSFEKLQFKKCEDKYILDQHLRTCFSYLLLYIIKECYYIYKIKCYIIQNALKIYNSQSKSSILNNYKTLSYLLYSQKWDNNIIYDIINNSNYFCNYFELFNGENYFTEDIHKTNKIKYLPNPYESVKNSINLKEQNKYEEIPPYIQFDNTTIRGVTIHHNLENEFSQILNGIKPFLSTNENPNNKKRKTKNKTIATININEKNQILRIKNLKNIQTTENSFINNKNQPNKMNAIIDTGNYFSKTFISSFQNDINKTDTDIFNESIYEYGQNSKYLQHIQREILNNNIVKDGISIFEYKTLHNIDHVNKFSRNCEYRDNSNLNNDAGQNNNGKNENGGDKEKEINNNDNSNNSEKDNSNNNQDKNNDQNQGGGEQNGEKEGDGKENDNNNDDNDDNNDDNNDENDDNNDDNDDNDDNDDGDNGEKAKEISEKEKYKFFYKKIKEIKSNIFVKRCKNVEKYFKKKIFNYINKNNIICNMNIDTIFIYLKNIYYLILNNKQLVFFFIYNTNDVMTAIINTEKCNEINYSEKKFFLYLLTNEKEIYKKIFDEINLKYDKNELILKLKKLKKKLNDLKHTEETNLFEESMKQLGLFKDIKKCVNSNNSNSQNNISNDDIYKLFNYTNKKFLKNYKGVSHKLSLKNLLPKLYNCKDLKETNNLICNVGKNVKSVTKSGGGVGCDGKKKKKNKKNKEANMKKNNMNNYMTNLNSHYNNFMNNNIDKSQINNSFNYFVNFQNNNGQSNNNVNNYSRFYNNMQYAQHMQHSVNFKDNNLNDKNGNKNNETDEKGDENEVKKKAIRGITSFTLFAREKRKELLNQKVFLGSSLTEQTSAVAKIWNNLSDEKKKEWAVKASKINEENFLLQKKKKKRKFTAFSIFAREKRKEYKEKNIDMGLTLAQQNSYVSKLWKQLSNEEKNRYKYLSNTVNAAVAKNNKNQVNYINGQKVSGFKGRIKALDNMMSQHFSNNNNLMYNDMSNFNNNNINNSSNSNNKMVYNPNQVMMGTENNSYNMNYMANMQNMQNMQNMQNIAQGDNNMNYFNYMENMNKNITMGYMNNDMNMIHDNGDDKNKKNSLKKNKKKKNENFNDPNQLMNNPNYMLKNANSFNQQNYNSLPYHNDGLNNTNNYYPLTFPNDNNDEMNNNNTINNNSELYRNIVINNNTQNLITENNQNVMINNMYDQNQISINANNIVNTTTQITNMKNNMTINSDVPMINNTKGDHNISINPIDNNELIQGHANVYITNGLNDNPGISNKINFPLHGHSEFSYNKYPNETNEIYEHDNVNIGGTSNGQTNMVMHNYQVINGNQKKGTKIDDILKKKMMKDEKKKLKEEKMMLKEFDKRRKQLLKAEKLMEKNKNKKMSNSDNNGIAAIDSNSGYYDPASVMNNNNNNNNNSNNNNNNNNMGMYMNMNNYDISNPLINNPMINNYNFYANPDKKNINPLNNNNINIVNNAPSSISTRNNTNNTNNNSGIISAPTDEGNNDDHLSNKGLINFKHVINGNGQNISNDDEFSNYTYGNKFMTDSGGVIRNNNSIPNDTNIQISDDIKKYDHVINNNIHDNTKLGNHISDHQHISNDQIQNPEINSSVINSNIPDGLNHPTYLNSNKEYYNNTNYFNNVISNDQVMFQHTNGTSNVVNNGVPIKYLIENGSNSNKIYGYNNNNNNNYLNNINPNERTANGISGGSNNNTGIIIKNDEYFNTIAREKENNNNNNNELKVDQTFNNTNYYQKNGTNKYTNRNNTNVIVGSVNNNNNNNKINNSISYDPDDNNHTYSNITNTSAHLHNSKQHNQSQYINLNETINNDMNMGINMEYNNGMNYININNNDNNSNNNNNNNNNKNNNKNNNTSYFYPHNRNNNVPNNNFLPKTNENNTTALNCMANGDNIMYFPDHVVSENNKIPGNLVYFDSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFB4</accession>
    <name>V7PFB4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFB4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="47" mass="5528" checksum="96E7901C7A1057A2" modified="2014-02-19" version="1">MCVYIYSLQAMSQLEDLEIECFGEFLKINILKKGINIDIYKNIIKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFC5</accession>
    <name>V7PFC5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIMP protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFC5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004765147" description="LIMP protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="13019" checksum="3973AC9F9952E1A3" modified="2014-02-19" version="1">MVIKLIFLFVFFLMSLNLKLALTKIENENKHNTFLQIDRDMNEPPYPVINVHYTESPLSGDLVKQIENNRHIEKYETQNYFRKGLESNKYFMDYSQNQKSQLELLISTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFD9</accession>
    <name>V7PFD9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFD9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000012">
        <property type="entry name" value="Dynein light chain 2B, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="84" mass="9914" checksum="C21CCA1CCFA34795" modified="2014-02-19" version="1">MNIGIPLKYNEDANYEHAVKQASLFLGLLTKTKKCVKELFPQESEFNNNLRIRTNKETEYILCNYGEYSLITQQNCKDMYNQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFE9</accession>
    <name>V7PFE9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AP-5 complex subunit sigma-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFE9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030119">
        <property type="term" value="C:AP-type membrane coat adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029392">
        <property type="entry name" value="AP-5_subunit_s1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15001">
        <property type="entry name" value="AP-5_subunit_s1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="18647" checksum="0EA894F283B60CE6" modified="2014-02-19" version="1">MVYGIIIHSSESEQLYFSTYYNLVNNDINQNSRQQIIIKKVIEEINYYKEDKENNENINKKNKDKYLDIFGVFIPRTSNDEFKIDNEGFFKIENISLFKNKINIMWKVLNKVCYTLMFFPHENIHMADNFLNTLIYVLMDNYEHFGKSNKNNMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFF3</accession>
    <name>V7PFF3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1646" mass="194384" checksum="0D73C43F823D4757" modified="2014-02-19" version="1">MDKHISDMLYSYNHNNVNIPFEDDKTKRSRKNLINPYKFKEPIQINKDINFYNNKIEIDQTCRINQKDTNKSKNVFKKNQISTKPLTSLEDTLDNSMLNNSISENVNKNKNKNNKFSNLCSDYKEAADDNHEFNIINNFKNCGNTQKFSKNVIIQDDTNNKFYTPKKESLEIEMKNDKNVNILTEELKKQTIASLQDSNFKNIETRLLRRHTTCENEKKEIFLKQNYKNENSSFTTNVYNTNSKCFNKKKNSDNNLLKGNSFSASYDNSMDGHTKKDIEYPTKLYMFNKVTNNDAKVIDSQKEKSIYIDKKGLFKDVCKSYMDQKLEIWYETDNHSNKEDDQENFICDGNKREIQNMVLNCSNSILNTSNINMDVKSDYNISNTVHIGNSTYIGNKVIVAGKKKKKKPTTKQGETHTCKIGQENIEKINVEKGEVVKESNISNAIDFVPLRSNSDHSGNFCEKKSDYYNIIDSNEKNVEKKNIKNVKNVKNIKNFQHFEHFENIKKITDFKGNSPNLYSWKKTVFETLRKNKNCENKGSNDSSNDSSNNSSNNSSNIMDEENVLEKKQYVNVMNPLKSSIVEKKEKIIVPTDIEKNYSSNQCNRNCVKCSILNLSNKKNNCFNNFCHTSSDNNSSNEHIMGKKNCKKIVKKKKNKNNPRNSIKNVTLINAKNCNNDKKKKKNIDDFFPSTYFLLSNGAEKTNLSSSDIIEKKKLYNNLNMIKNKYSIYSDNIKVKNSAIYNVTNKEEEMLKDEKTKEKCGNGISLNMPKKKEEQNAGKMEENCIDFVKCENELSNCVFKRANYFCNEMENGSEEMKSGSEEINDARNVCGQNNCKKNNAMHDILSNNQMIIKDIEEIKKNKLFFEEICVFRMNEYTEESEQSDIYNYSDIKSELYQSEDDYNKELKRKPINLFELGSYNDIDITKFELNKNCYEHLNDEVTKLIKEEENYNLEMNIGLMFKKYINVIMNLSYNYLIIKKNEKNVLTCISYNNIIEIDIVKKNPKKGKISFKLVYVFKKKELKAEKNITLIFKTTKMGIYEKIKEKIGPLFNSGKMKSSFIGNNRNNNIVRGKTGTVSKIDKKKIYIDVETVYNYIINKYKQVHLLYLNHLLQISEKKFKKKSMKQGFEILRLNCEYTKEIEEIRKKKNKLINDFTNKFEYYIKKYIQKNYFNILLIKSYETHFINYQKKTNNMLFNVIVKEKSAYEENIGRQSILLLFNALTSLYKSKMSKYFRSFVNNNRNFSKGKNAFSYTLTHINTILVKYETRHKAFVLSRLKFNYNNVSYFSFIMYKTYLKKLFLGYICLRDNRIFIKLIIEKNVIKLINRISRVIENQKYYAFLKLQKYIYEEKEKINKKICDNLMYTNNELCNNMDKIGMEKGINILEYLYKFKIKENLIKYFYILKGSQVNVSISQNKYYIKYSSIFVFVLNKIFQKKVQDILLHFVLKCFQNNNKNKLIYSTKNLELLFMQKEKRDVISILRFYDKFPYLFKYKNMNKAEIFTACIQNFMNTYNRKLLLNFLLKLHFLRYKEKFMKAYNCIGHIYNFTNILSKKIKKTIKFPFMLLLQNVRIINNQILMHRLKIKKKTQLKNSNHTRTFSSAPDPVSVITKYPYLLYNMEMSPDHTFVPGKRPCTRTYTRAHIYTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFG3</accession>
    <name>V7PFG3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFG3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="205" mass="24283" checksum="E4D5FD313E878540" modified="2014-02-19" version="1">MDNKKINMKEHQWRLFEYNMSKWMIENKYILDNEEKKKFYKCANYSIGSGMLNASLIYFLCKKNQKYFSSMSRLFLTCSLGIYTSMVVNKIYRRKAYTEILTEKTTMTDKAIEVMNDILNVNNNKIPTNETNNLTNKINEYNARDGSDIKTNSDNNRNENTENLVQNLNETIMREQINELERCKDVSICTDENIKNMIKTLEKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFG8</accession>
    <name>V7PFG8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Endoplasmic reticulum oxidoreductin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">YYC_04559</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFG8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="110"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="364"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETB57740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="48974" checksum="00C71B0E5221F39B" modified="2014-02-19" version="1">MKIYLISYIFPTLIYLLYILLKNQKSLSKYNNYINSKINDVLLFFNIYEIKFPNSYNNNEKILGLHIRDIEEDSRIAYKILKELTQKNYFRIFKVNLHVPCKLQKITEKCNEKTKCSVCECTEDEIPYNFRTNEVEIIHDKYAQEDLKKTFIASKLYKDILGTYDPSDEGFLSYVDLIYNSPSYTAYEGKSIWNRIYLENCFQNGENSCKEMNNFYKIISGMQSCIAALSSEYYYLKNDFVFGDMYTDNTIKNHYIKKIDYDYNLSFFKEKIALYPDRIENLYFTFAILLRALCRLKPLFSQCKCNSGIKENDKDAFKLLNEFLGKQYHSCSSKEFLEPIFPTHGKEILSKFMNITSILDCVPCIKCKLHGKLKTTALQIALVEGVGHEHIGSLERNEATALINAIYHFADSILIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFH7</accession>
    <name>V7PFH7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFH7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="80227" checksum="85403E8B4A195108" modified="2014-02-19" version="1">MNDKKKININDLFKNSNVNRKDGKNKKSNENEISIKKKNIWSLFSNVTETFKDKTNEECDNNENDTDIFFTPKNITQNIEKNTNKTLFKKTHENPEIKKEIENIANSFKRKNNILLTDKSDNTILSSILSTKKIKLNSEKNETPTTPTYNAYKEFFMRIKDQNKNAEINDGNTESYQDKEKKTMHTNLMNIKVCSKIEGDDVNSRINKLNEKNNQPNKCHKIITLNQTGSCIPYKTELVTSVKEGDNKISFTSIIKKKNICVPVNNQNKMEIKKKSDNLIKRAHHFSKHDKYDIFNNIGDDIFRYIFSCIENKNLMLLNKRFCKLSRLLRKKLIYNESLKNSISPESILKTIYFSVNIEVLDLSGCSHITSHHFNILANSNHIQFNKTLKVLCLKNCNKITDSNLKYLLHRFKNLQIVDIRNCYKISHEGIYPLKFKTSLKKLYMGNIISSINVSNYHSDDTLKALFSAPKNCSAPSVDINYNANITNHTNMIEENIQLDTPLINLICFEITYTKNLTDISNLYMIGKNLKILNLKGCNIDNSSFIIFKNFPNLLALNLADTKISNDVIETVCNTSKGLKTLDISKTFEVRNSTIFKIPRYLTGLRKIKIASLSNVDNFCIREIFKYCKNLTSIDFSNCWKVNNSFCNVNGLEIASGNKLKDIGAYQCSIDRSVCEEALLRMGCTSIRVHIYNVSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFH8</accession>
    <name>V7PFH8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_03950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFH8"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB58321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="452" mass="54140" checksum="5C296CB5E9A323FB" modified="2014-02-19" version="1">MGNSITEKRSKIFKQNKSYFSDINNIDYTKKIIYFLGILVRIITYYYGLWQDKNLNVKFTDIDYYVFSDAAKYVLNNKSPYNRYTYRYTPLLAYLMIPNFIINFSFGKFLFSSIDFLVSIIIIKIIKIKYPENKNYILYASLWLLNPLVITISIRGNADCIPCLLVLLTVFFIYQKKIYVSAFFYGLSVNFKIYPIIYSLPLMLYLNKNYLNKDNIFQLKQIKTEGIYINKIIRIFYIIRNFFKELFKLNTDQLKFSLFSFTTFLALNLIFYAIYGYEFLYESFIYHLVRQDHKHNFSLFFYIMYLTIENNSKIIPLITFIPQFVLVALFGFKYAKSNLELSMFLQTLSFIALNKVITSQYFIWCTPFLPIILNSITLNRTNLILIFCAVLFFVIAKAHWLFWAYFLEFKGYNTFIQIFYSSILFVISEMSVCWIFMYMSFKEENKKNVLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFJ0</accession>
    <name>V7PFJ0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_04410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="917"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1284"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="918"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB57537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1643" mass="190287" checksum="587AF757F5738195" modified="2014-02-19" version="1">MKNNMNIPNNINNNMNNNYNNENYNNVNNNSRNLINNNLNIPAGLNNMANNMNDRSNNMKNFPNGVNGLNKNIGNINNINKMHNPIGKMHGHINNIPNNMGTMNSNLKHGVQNIINGMPTGINNMHSNLNNIPDNIKNMANAMKPMPNNINDIRVNANYSMNNMNTNVNPNNNVNIPNDMKHMIRVNNSDITSNVKFNTMMNNNNNSHFVSPDNSNRNMFYVNDMKNVDNNVINMHNKRNNNAKEKKNNIPQFREKEYLENVGHRDKYLLNKNETDKIYLQNKQLNNMNQGNIPNINNNNTRNNNTGGISRMINNNAQNTININSNNNINSVTNIGNNNDNNNNNNILQRNMKNLENGGMHNPLNINQMNAMNLNKTFNFSSNDPHNFNINSAADNKMSNKFKDSNYNNINKNINIPFNEESKYDPYNLGNNINRNNGNNGIVVEKNMNNAEHSFSKQHNNGMFDIKAHSGKDNFGGIKNMNDDKNIRYNSKLNEMNNANKVGKDIINLSASNIQKLNEKNQKANGNSNTNFMGNNLPKSMENADLYKLQMNYDKLNSNDPNNYINKMDNYNDFIKENNKGKYISGNKYNANANTKGDQSKNKTQKMENELINKKFNPINNNNNNENAPNHHMNENMIYDEMKKMNNTSFEKMVGNDMFMFNGNRSLEKGINQMVNMQGFRDIKNIHNINNYRMANDNDPRSNEKNNNMFHNQRPNFEGCNGTENLKGTGNELEEKKRKKKREKKSEMEKNEKNEKKGLNRDENLDDKKTINQLIEHNSFMHNLNENNESSEVGQNIKNNLFNDISKNYMQGQNIGNDEKELNIDSNLNENMKKENYAYIRKQNIFENYENMNNLKNAFLEGDQNMLNNANIFNKINFKFQKKKSDDSYENASMFPNDQNDEDKKLMVLSRLFGNVIGENGNNNNNNNDDDNNMQTQNENNMNNSGKLPNIRKMNSNALELELYKNMPLDTMLNKLNLDKNILNILKDKINNINRNINVNICSTSMETPEEPIKMENIDLLKLINLFDEFLNWSENNLYQIKLQLYNIAFCLLLELYILILANKFSMLIDFKNKYLKNFEAYHPVIKFLSNCVSLNQIFEISILRFKEKNAKHIAYMNKLGKASLMHYLSVYGSIPLYNLIMTKIKIIEIDDANKNFNFFHEFISMNFLYNGNLNVPVQWNLPSIYFIKDVSETQNDDSIKCTKEKEENVYIPNENSDAYYYYKYIIKMQAENRLKVTKNRMPSMLYYCLNNCTDMTCAEISSFDGSLVATAHSNNIIKLWNIKKSQMNKIKEKQKDMEIYNNENVDEINNYSNIQENKPDSIHLDDQDENGIAKLYGNMYNISSLCFGETNKILLSGNLNGDIYLYSTISNRNYVKYSGGHTPIWSIDTAFLGYFFCTSEDDGNLRIYSTNKTYPLVTYKYNCTSNICKYHYNNTIVASGYYDNYVHLYDIRVNSFIKRFKNNYPSNNGVTSLSFSKNGRLLSFGGGYTNNINIIDLVADKFIDVEPKQFINTKEYNLGDYYSNTKFEENHLGFYPLTNESEKLHMHKNIEEFEDKILSIDFSYDNNLLVSMSCDSHIDFYNCSKASKELKHPSTEKKRIKSGKDHKNNNPYVRLSKSYGVNYSNLISAKFTPENVLLLFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHG2</accession>
    <name>V7PHG2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHG2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="69154" checksum="0B4B820741D175B1" modified="2014-02-19" version="1">MLNEQSVEVDLKKIETELVSCHDNTEKTKKKKKVQFSEKNETLYYEKDENENSYFNFALNNFNYFESFYNRMYNADFDDQEIQKYDTFLNVNDKILEYNEMDDEDEDEEEDIQDNFLKKNNLVNSTFKGVNKLKIDLHSKINKGDSNSTSDDNNEKNNTNNSKKDKFVQSFNEDCSFEINDIQSAIINAEEKTTHYNKDYFGYEIEPFNMKNELQEGYIDKDGNYIYHDSKNNKVEEAWLKSIDENDSFSNNKLQTQIHKETNSKSNNNINSDIYDNSLTVNIYDGLYSLSCLLADKETPIKAMIRYKNDLKNCKNYLNQCKTNLDEARTKGSQKDGTEENIKSEQDLQANITQSDGDKVDVEKEKEDKADVENEKKDKVDVENEKEDKADVMKEKGEGLGNTIQDEDKKKMQQLEEIYQKALLDYKTIERQFNNIIDLTQKLTNEYKNVYFLTKNEFEEICKKLEECKESGNILWQLKWQSDVNNNIYGPYNYYDIYNFISLGIVSAANPILLRRVSNENKMLENIWQSYDTVNYLNFVNNDNVKKKRKLNEINIEDSEDDQKEVDSSTDDNEYDIQNKKKKKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHG4</accession>
    <name>V7PHG4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 5">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_04266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11 5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 5"/>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="7">
        <location>
            <begin position="928"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="805"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="872"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="805"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB58207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1313" mass="155464" checksum="DF9E736DD26C6816" modified="2014-02-19" version="1">MNLNENKSQNGFNNAIQENDDSMSLVSEGLDGSGNEDYRENEIEDYRNNRKEKYEGNNNANTHESLLKNNKDNIDSKLGFDIRNVLRHAYLPVCIEKMKEGEYVYKWNNNNIFQKKTLKFVYLDTNNYCIRWNSKKKKLKENKSLALYICDIIQILDGSESTFFKKKEEEKSLSIEIISIDRNLRITFLDIQRWKMWLFGLMYYHYKLVNKSSRERKKLKPFIYESNKLYDNYIISGLKDINVLTLSQLYIILRSLNIYINMKILYHYFSIYKNKGTINYYGFTKILEHIFSNNHISIHFNMYKNNDSNYIDKNQFINFLIDIQCEGKSEERIFKIHKKDNYPRLIQDKVEQNEIKKKEDNHAQNWNNNQVYTNQHIIKDKNEHNISENISNDNKISKNNSMIDEITNGYDLDYCEWRNLMKTLDISDNQNEHNLQCNANIELNSFMVSDHSKQYDKDYAMILNILRDKYGVYSTTNYNDKFYMNSHSKSEKKYKREIYTYEENNRKEQTNEISKEDKNKDDFYFIRTNIIYKSLNTIKKYNIPFVIINEGNHYLTQIGLVYFLLSKENSIMCPEYAKVYQNMNLPLCNYWINSSHNSYLGRKQIFSASSIEQYIYILIDGCRCVEFDCYYFNKNIVVYHGLYGYKLTSSILFCDTLIACKMFGFSTSPYPIILSLEIHCKDKHKNLIAKILIYILGNQLYIPKTKDEINNITPNNCRNKFLVKYKHFDNNYTSSFYSIFEGLKNVMYDELGYFSDIINEQEDIDVDEPKEYQIIEKKNEKYNKISIENQNMEPEDRVNNYIEQNNSKNTSYKNNQVQKTNKNSDQNNLCGNENVSQRDRHEVDSNYSSSSSSNCLYENNTIHKTQIDEKYRKNDNCSNNNSGFNNSSVPNNTNTSDAITNCGKNMSETAHMSKEEYKKKQDNEKYKNNILNKCSCLKGYVFRNFQENRTYNEICSISENKFIKLIKKNEDDVIKYNQKTLTRVYPSGTRLASTNFNPLIFWSAGIQFVALNYQYNGLSMLLNKGRFLENGGKHSGYILKPELLRFNKKHDYNVLSLNIQILSLHQINLLFSIKNKYQEKKLKKELFKMDMIQRIQTHKKISNKRKKFKYLQKLEREKKSPLLSDIQSDDSKKKKKISNETLLKKFKDNDNDVNYIHKKFANIEKEYEDMLTEYKSFLLCSTLSHSSSFNSCSSVTTTSNNTTDSNKKVSSKSKKKNFYQAFLELKKANNLFFYLYVTISIHGYNEQKCYFKTEIAKVNFYDINYCWSKPSNFQMKIVHPSLALIVFELKSYDTVKSDIIACACFPVKCLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHH2</accession>
    <name>V7PHH2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_03732</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB59001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHH2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF198">
        <property type="entry name" value="METAL HOMEOSTASIS FACTOR ATX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB59001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28159" checksum="B90833C70C7BC39F" modified="2014-02-19" version="1">MLPEVITLLNKNNLTIYCCFGLILISVTFLNITDILYDHHIENCSDIDNAENKNTNKFTINSTSDQNNTRDHIDIEMKPISVKENTNLSNNFIFDTFKSNAFFIVLSLFIHSFVEGLLIGSLKDKNPIIIVGLSMIAHKWAECLMIYKNAVKKTEDPILSSIYAWSFILSLPLGILVAVLSFSSNEFVEIIFSSIACGFFLYLSFNMTKDITVTKDNKFYISFSYFFGVCGMSTLMIVFNYLENSNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHI5</accession>
    <name>V7PHI5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spt4/RpoE2 zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHI5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000004">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="6">
        <location>
            <begin position="30"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB58899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="120" mass="13686" checksum="3AD7C184D504E324" modified="2014-02-19" version="1">MKKIDESFVEHGDSVKKSRNTGQDDKALKLRACLSCRLLRTEAEFYQSGCTNCKFLQMTGDRHRIQDCTTENFSGFIAITTPTKSWIAQYNDLSKYNPGFYALQVVGELPESIRDLKSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHJ4</accession>
    <name>V7PHJ4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHJ4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1232"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1236"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1267" mass="152784" checksum="8E9754543BAAD44A" modified="2014-02-19" version="1">MIQKKSGQMRMVIRKIEEQFLYNSIQNNKYIKNKFSTQNKILIYEYVNEENCFLSKKGDSIKSIMNYNYVNKKINELNYILKNEKKINTLYKDKIIDNLYILCVKGNIDLYDDRILYYVNHVLAYINKYINNDGDITVLPQSQVSEKNISINNLNDENENENENKNKYENILDIEQYIKFLKVLKVLNIENSFNNLFKYISKNINFFHIDIVRKISINHKFNNDQNFFFKDVLNYIYTIIQCNNNIYYKEIKNINICLNVCTNFFFGKKLSKKKATYHFVENYDIVYMYNLNYIYMNHIIVIGTILDGNKINQKNGEKKNIHTQMSNINNITCTPNKRNETKTYMNKKNCKNNYKCDENILTEMEMQNNIEKIEIDTKYIDDFDFNYNLIDTIYVAYKYYTYLEIKKKKKKKTSHNDNNEHGQNFFFCLPDIKKYITNIVCNFINIINRDIIGGKLKNNKKIILSLERINALVTSFDVPFKLDHFLLYHCNILLASKIDLTVLDNIKILGLLRNVIKRETKNLEKKKSSNAVCNDHITKLSNSLEKKIKNGDNNGDNNGDNNDDAIIKSSSHLTPLNYENEINKRIDWSLFDNMIKLIFDNLKNCLHNCQSNDLCLLIPMVYEFHKYMDEEIKNILTVQVIFNKDNINQNNIINMLRVFSKIKYKNEAIDKFLYNRLKIFNSNCSDNNSSFSHDMSEENMGNNGFSCPKNFYLFFYYKSKNKLFSYKDIYYIENYIQKNFFEMNIKDFLYVLLIYYKNGIFLLPQLLLKIAVIFNNAKKNIFHDDFLFCLFLLSKNYYLLSMDSNNSNIFTHMDEEENNVYLNKMNMFRKNKYNQHHIDNFINIINDMLTYLYDDKMINYKPEQLKYKNNVEDKIVSDLYEIKENQKVGDTCSKEIKRGDILLTPNDMFNRDEQINEFKFVFQKLKYNFIMMKIFYNFYYSIFKNNKKNEKKILNSQHEKFILYLFSCFNQNFSKDIKEIKYVSSLLYYFSYFNIYSAYYFDKQMLYILQNCEFDDHKIITNMLLSYVFINKEIQSDIKKHIKEYIIKNFEHFNKNDAILCFKYSNYFLNLQQTEDINKSHDYILFIKLLNFLVSNLEKYKPQHYLYIYTTICNNFVREKRIYIKLFYYMNKFATHYNFDQLFLILFYMYKTGYSKPKIRKKIRNLILYYHKKRMINLSTYVKYILPLDEFGIYHLFPIKFQNIIYNQLGEDIKTYVRKPLMDNENIGKTNLKNVTPKEQENHVQDDRKENNGDTPIYIFEQMVKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHK3</accession>
    <name>V7PHK3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1540" mass="182586" checksum="F5DE5B583A05DC64" modified="2014-02-19" version="1">MRDKTHDKVDGKYKFQKLSQKHIDQTFTVQSDSLTEPLCIVDNEKPQSLYDCSANIANQQTKVQYSNIDSHFQNGNNDEKDSKGDDMYDHNFSKYSQKKKMKKIKEKKERKKQRRKKEKIQNIKNILENDKKYYESYINSYISNNIPQSVDENKFFFSFLKLEIIEDDGIRVLKKNMLNNIIPFRFSVDARPEKGRKKVAFKYESLFTYKNNNLLGNCDNKNINNNNNQIGIHRNIKKIYDDTIDSNFNKTVKYIGIINDSDKYMIDYCKRKIMKRDKSLLCLDNRKLVAKICSKNKIPLLWIRVDNDFYIIGRIRRTQSVSMWIQQLLNDNNVLAQLESSFSLAFIPFFFLNKNITSNFNENKNNYFLGPEKSSTNINNNSVHYGDLVNNITSIGSVDSDENINHLDPDNILAHNTQKDNHTDVDANFLKFSATKIKNKQRKKNNLQNNNNSTDPANFPFNNITSNILAKSDQSFSMLNESYTIDNDQNRKFTINATNKNMINNFITSHQQPPQIDSNMIRISHISNKNEFENNIQNDLLKINKHYSQSSSSNMDSDSHDLNFTTSTIDDLNEDVNGLENCNYSSSSYKMKEKKNYKTHCKKNISISNMPINIEIIKALYKSIISEHLHYIVKIRCIYSLCFVHNKYIYTQKVIQNIFLEYFDQNFPKDLNQKKFMHAFFIALSLLRNKNNRTPKIILFLLIKKCSSFVLSINLHNNYNITKNTTYSEQDNTTSHKYISNNIGNDNYQYLGNNTTINNFTKFYSNPNQENVQINTTENVSQSNISLQTINNQFQNSKNYITKKKDEYNNVKTSIDYTNNEHWDYKKNIVQKISQITNNKKLCTCNKNIHKLCDFCKNDLNCSGKKKNLQYNQNKENQQKITYDPDLIIQKEEEEDIKMVLECIGNIKFKNQCLFGNQNNKFNGIGEYKTNSTTNINNISKSSSEYFFFQYFTKLTNNTNTMPTDTNYMKKRKKGKRKKMYHAYDFYDIDIYDGEKKIENHFLKLRKTKKEYTQELIDLLFLIYELKKLSPYLPISDTVITILLRSISRNKNILDLFRNKMYIENKYYFDMCAYLPNFIFQSKLLNFIDHKNANNFTIEIIRAILHLIMTGNIRVYKIYYKINESLRSGMDTIISSLKKNDNIMNNTVNDNNLLDNQTKKEISKDEANNFSKPYGKCEHTTFKDINNENEKNEKNEKNEKNEKNEKNENYFFVSTYTNFIERKVICMHLLNMYAAIQFISQIVKIFKNCEIEMLIWNIFYQLLLIFQQKYPFFFLPFSKLFNKYFKDYQKKNYTAFEFFYFLYGLNSINQYEKANKINDYNNITNFDDDNDKINIIPYLNNQYKIHTDNKLICDYALRNILFEETFTNYSSKIKEQNIIIYKYDIIGYIPLINILKFVSNTKKLKKNFIQITYIKYIVKYIHNYFRELIIDTSKFNENYFKNSILYDLKNIFVFLYGYGIPPCYSKTISPIYFPHYKQLNDNTKKGVEINSLIKFLRTYYNNEKLLKWKVVASEFISVLKNMPELKLFIDNPTISLNNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHM3</accession>
    <name>V7PHM3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHM3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="861" mass="101748" checksum="870A5E0CFD42F013" modified="2014-02-19" version="1">MSEYKIKSSYFSTKNKVILLICVFFFSCSTHIFKNVFPFLFMLTNSYGKDSNDHNVKIDINNNKTNKFYKQKNNNNVTRYPNKNYNYSDKYLNILEDKFDIDSGDMVRQNYKDGNGGNGENDENGENGENDENGENDENGQNGQNGQNNKISNHSIYLYSNVLTLIYISSLVTYVFILFFDLNKKKYILSSLYIINLISHCIIFLILNRIQISNKNVINKNGHNYKHMNIINSEHVLQKKNYYEFKRKEINLFFHVNLKNNFIHNFIEDYANLPYYNNKMNKTCFYNNMDEKQINDDIYNTKYFYLFYLFIIISSVCSAYIKIYQKNILYCIFYLNIGIITSLLILMNSIFKIMAHSLNYIMSNNNMNINISDYILMFSFIDMFGLFIIFVFSYKWSSQKKLWVNLSTIFYNYKYICFYINKTYYLYSTDKNIDNIIAQIDMCKDPNVDITFSAYINIEKSIFYDFFLKNKNEENKLNIIEIKDKNFKITTTYNTKNAQYNENDKSIFKDVENPNITPSYNRKKKHSHTIKPYKIHIETINKDLFEEMENLTNIEKEETDKIVINKSNSSNNVIPDTEDNKIPISSINNSINKGNGYSNCENLNDIHLFNDSSIKDKIEDVENKNSLNKNSLNKNSLNKNSLNVNVETNLNTNDNSNKSSNDFITNIKSKQPIIEDEFEKTINITEGEIEEKKNKFLVPNHNEDDKYIDYDNYDLSYKNYNSPLFIKRDKEIKNIQNNFIIFQNIKTIFSSFTFYFFFFIFIYAFLLSIMHIFVNYFFYIYLFVFNINIYISNIYTIIMTFVSLIAIPFSGYIIDNIGSFLFLLLCSSFFILIAISGTIYCCIFNLRSEVIAFISFNLIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJJ0</accession>
    <name>V7PJJ0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJJ0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="40548" checksum="7FB3B57EED9F16F9" modified="2014-02-19" version="1">MINKAIKKLVSKNFLCFTSRQKQNKIINHNKNIISINVSGIRNVSNIRNVSNVGSGLFDGIPNEEIDKDKLIYLVKNMQMVNLKEKGILNNISNLLKRHMNQFTIDEIYLIIHSFSKLDFRKYSLYNNFVKIIMTKKPVINTRTLTQMLIDLHKTSSLDLNALTFFTQYYINNLVKNFSLFDLSMILYIFNKYNYNDFITVNKICQTISDHFIPIIDEDKGVLTTILLSLSVLNLNYEIYSNFLKLYVYTNYEKFEIKYLCNISYSIALWLARGSVKDKFLSELLKDIVFLLINNMQKLKNDELKQVHNKYAMIILNPTIFILFFLFYLCYSSSILLYYFFTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJJ6</accession>
    <name>V7PJJ6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin fusion degradation protein UFD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJJ6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB59589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24741" checksum="DCD4E009DB1688B8" modified="2014-02-19" version="1">MLFEVSNPYTEKRTHSGVLEFISDEGTCHMPYWMMQQLCLKEGDIVRVTSISLPKGTFVKLKPCSKDFMELSNHRTVLETALRNYATLTIGDNIVIHYLGKTYEIKIVDLKPAFACTIIETDVEVEFEEPFEKVQYVEEIIPVEESKFKGKGQRTDGKACKNVKTEKVRQKIIENPEPWKEKLVGGVRTKCAEYEDLLKKGRIPGIIGKFIERKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJK6</accession>
    <name>V7PJK6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJK6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="91"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="532" mass="63063" checksum="170A7B71E06F61CF" modified="2014-02-19" version="1">MGITGLSVPLIYASLMVYNKLINNNKNLSDSEKILGKYLYKHDNSIVAKNIYDNDKSFNIFYIITNIYYNLLAYVNFYINAKKVKTKENGNDYTILFFHSYNVDKFLQSRNIKTYVDRLKETYKLINKNNNVNIVYVPLDNKILFNIKHFSLMNNWYSVIFNDKQQVLKLIKNYNIMNIPTMVLLDKNMNVVNDNINYLLLYNSKDFPYENTNSLTYINNIYDQNNNQHNFKKLDSDYVIFYFNNDKENKQDIETLIKIKNNLSKNNIKLDIIFIKDIQRKPEKTNSSQPNSSGVKNEQNEQNEQNEQNEQNEQNEKTNYMNEIYHLGKEENNSIYKLLLYDTFDVTFKPISILVNKKGKILNKYINVNKKNNDISNFILNHHKSLKEKVNENNYIYKYDNISNLTNLNVFAPIFILFLDKLDFNLLNTYNELIEIYNQNRKGKKINFYLVLNDDKKYEALKNLCSVNNTTQVAILDLFNQKLFKENVNNINIIQNVDGKYNINKDNFFKFLNNFYSDDLYSSPIVLTKPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJK7</accession>
    <name>V7PJK7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJK7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="21744" checksum="96174CBE0AEFA8C1" modified="2014-02-19" version="1">MYNFFRSYFSEYFEKKRKFNTLVWHCVNNQIEIYIQQALNPIKKFILDKRLHKYRLIFKNLKDQVLKIYTIEFEQFYKTHSTEISYSSIENFVWDFFTYAEMCLSEQNNIEKTFEIAFDLLKDCEDNSEINESLKDDWELIPHESQNIYKKQILKSMHLSDNSDPRVICQIYVESCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJL4</accession>
    <name>V7PJL4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_03151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJL4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB59751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="647" mass="76604" checksum="1409A7B9F1FC97F0" modified="2014-02-19" version="1">MIDNSENHASGYEMLIEMPNTTISSNNNNEERKYYEIYGNNKINDKDIYDNSKDRNEGEFEFGSPVNYTIGNKNSSEKYCYNINEKKKIETDIKYCGYFFISLIFLLFFILYYIYYGNYSRILYGTNYNGLICGKDLKSFKYLYYPLSPKTSKLEILNKYPKCLESCPTSDFSNKNKTDEDNLYGEKKKKNFFEENFFFPFKNNGDKNKGKIIDKNGNIETSVIYTDYTKGPNNNLYVEYLLNSKYYDTVNIMNICYPRDKMLREKVINVVFTNRYKIFVNLFSLHNSFFFVFLFIIVSILLSFLYIASLYYFPKFTFYIFIIFYLISIFFIPIYFVHNHLYLIFDPIKGSFFSYHYLISILTSFIMIIHAVISLIIFYIYKNTYKYTSKLIAITLKFIHDISNIIYAPIIISFVSILFFCVWIYLYVQIITSGMSYDQKLDLDLDSNGSSKILSLQKMFYYFKSSYLFSILWVCIYFFICEMLQSLNQFTICHLGTVWYFSDKKKSECNQNVVEEMKTIMKYHFGTIVLSSFINLATKHLRVLFFWINKTLSLPFFFNELIYNIKERFHFILNPMSKIVDMYTTSAYCEMSMTLYPYVTSCHISSKKLTNSTSPAAALHGISYITNIIFPGFTTMIITFFAFNVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJL6</accession>
    <name>V7PJL6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJL6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007732426" evidence="2">
        <location>
            <begin position="22"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="404" mass="44586" checksum="ADCF4D1F211C425F" modified="2014-02-19" version="1">MNNGYIKIFFFVLILFIYVNNNQVLTSDCVADNAASSPVAPFDIDSLETASFETASLETASLETVSLETSSFETTPRKTTRVKKTKSKRIPYKRIPSETSSSESLSEISRPKKPRSKKTRSKKTRSKTAQSEIGISKTASPEINISKKKRSKKKRSKTTISKTPSSEINVSKTASSEINVSKTASSEINVSKTAPSEIDVSKTAPSEINVSKTAPSEINVSKTAPSEIDVSKTAQSEIDVSITASSEIDISKTAPSEIDISIIASSELDISKTEPSGIVLPISVLTNPPSPHIESIPVSFKLDKIYKKSKHLLCTNPEETKKATEVMEEAVELLKYYAITKNDYKYYCTSDEGVDIYHRSHGHKFYIGKCNFKISNPEKYDDIVEILWDPDGPKKFDDNHIKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJM3</accession>
    <name>V7PJM3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_03732</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB59002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJM3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF198">
        <property type="entry name" value="METAL HOMEOSTASIS FACTOR ATX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB59002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="25020" checksum="E415F3EA02D29A59" modified="2014-02-19" version="1">MWLKLILAIVILIECIVVIYLPSHIESRIINKKKHKIFNMENFENVASGAILALAFIHMLPEVITLLNKNNLTIYCCFGLILISVTFLNITDILYDHHIENCSDIDNAENKNTNKFTINSTSDQNNTRDHIDIEMKPISVKENTNLSNNFIFDTFKSNAFFIVLSLFIHSFVEGLLIGSLKDKNPIIIVGLSMIAHKWAECLMIYKNAVKKTEVRSGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJN4</accession>
    <name>V7PJN4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HID1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJN4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="101013" checksum="D0670B14C8C0D487" modified="2014-02-19" version="1">MWKENNFEKLVCTNYVCNNILILHIFNFLLIILFTENISINSRNKNGQNNYEHRNNIVLAKNTIDIYKLWLVKLVTYEDNVETSNIITTNNKNTIFTNSINEYNINNKLNDENKNKEFSENKQTQNDDDNDEMNKTEEWSNKNNALGNDNNKYIFTNDIKCVEYCQVNDRNDNEKDNIKYNNSIDLNLINNRINILKCLLILLSSYMYNNNNNYLEEKNMCLYLFTSGDIYFSSNFFISLLSVIYDNEFNYFSFYFYNDTYLEFYNLCIHILNILIDFNPFVLQNNKKVHYISSALDYFFSVKKIASKPKREATNGEVAKNREDTGKNSDQASASQLKSYSHFDSIICSYSSEESYDSSEENSSKQYKGKEAICNIKRALKIKRNYLSISGDNNNSVNNDDNDYYEYIKNSKKIKYLQTRNIFLVMLRNLELNSIKYIYKGVLNMLISYKLYFENYEEDIFYINNYLCLFWNLMDNNKLLVNYVKNHNSSVFLFYILYILICFNNKRKKEMQLFSDIKKNEPLNGGSRSFNNNGNDVKAENLNNEKNFYNNEKFNISKKCDEFNIRKIDGLIYICLFIILKLSSSSIVCKNLNQKYNQKIKINSLIKNVYQFETYVDFLIYALCSLINDNIYFLKFERIIDMSIIILTNISVYIKSMSIYSCECIINILKKILKKEWILSSQHHHYALFLLLDFINNILSHNLSDNYNLVYTIIKNRDVFISINNLDVSLKDCFISTPNLDKDYWVPTESWLSNWKNKLPLHFVNAIIYDLASMIEEECDKKEILDHNEVVNLIKTECSIIKNEKIPFIIRKYEKNIFLSKWVTNYIYFLLFFHFYKQNIFINNGIKFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJQ5</accession>
    <name>V7PJQ5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJQ5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="967"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1256" mass="152976" checksum="82F630A8BD02564F" modified="2014-02-19" version="1">MNTNMPSLNGETNKMSFKKIKNKISKKLEKIISKLKQKELNEYTKDVLCVDLLYYRIKYDNDIFLCTNKKCKKYNGYVIINFFYSPRQYILYELKFKKRFFFDNFVYNNLELVKRARSLFELGSRYLKKSEKNEKSEKNNKRKKTKLRKKLNSIHNEENEIEKENRDVDINYIEKKNILFFSNFICKIYDINEMKNKHKFESIDIHFHIYINKRKINKYFFNYFYKKHLYDSINCHECENVCENEENFELVHDKNNENKIEDTDIHLRIYLKRLNKVEIKIKYLENQYVSNIHIKEKYIMIKCNIIFLCKHLKKKKNIKKKKNKKCSFLNIDKYLGEKKKITKYSNHYLIKKNFQYDKNCKEINKFLKNYTNSPRIYILKKNVFKYSRRIIKESILFASNKNYNDDKKRKDSKISIDNIVDKDKIYKYIKQINIDKNLVKYFQERYLNIIRSYIIQLFNLFSWEEKFEQNINKNIQHIKKNVYSFIDFIDMYKINDVIKLHNNMKKIGIENDKSKILILNRLINIQKKIWINILKAKNKNYKKKYIYIQTWFYRQIIFLTFLKFNQINIEHKLYTDLQLFVHEFIYSLLHYDNIILCKNEDKNKFSVFNYFPKNIKELFIYENGNYHFPFYNLMKKDSTKFFVDISENNYNKKLNKSKNFENKNNNNNINQYLKHEQNYIFLAKEYKAISNFIFYYKLHEIINNSIIYLRNKIYIFQDVNNKINSFVTLHYTCVYSRLNYVCDLVRKYILTFKFIPNNLIDILYGNFHNKLDQVEKVEKAEKVEKVEKVEKVEKVEKVEKAEKVDQVEKAEKAEKVEKVDQIEKVEKAEKVENEVSSKDSKENENKDPEYKNYLCTTNEPKYSYLNIVEKTKKNYAYIFIQNILNYIFIEHYFPIIPKYTLENFIICSLNFIKNKSQKKDAYSFFAYNLLRIYFKKNKIVDINIFYLPECIKNTNTLKMFPQNGKELSQYIFVLDFFFFLLFFFFASKHKGKNSQKMILQNYLNILEIKMHKKGIINKSEKLKILKNCLFSYEMLLKPKSVIPQESYNIQSGEMNVENKNTKSKKVCISFGEMEKSRMNFFDNDCICIEDKEQNLDELDYFNFQEFSDLCIFNLFLNKKKEKKNYKYETFLLNKFIFRFLFAFSQMPHFYENVNVYIKNYLFKKSSDFLSLFETCVQEKVEIISRSDSNIEKVYKEGHVCEKKKKKKSTYMTWNTKKKVISNKNIVKKGYIFVSLSFKEYLKSVIMQFVTHTNVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PK17</accession>
    <name>V7PK17_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_03276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PK17"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="9">
        <location>
            <begin position="141"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="306"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB59921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="59409" checksum="B23D806E4D31C792" modified="2014-02-19" version="1">MYTNSKNIQVKNKNAADVQITAEQLIKEALDFEEVEKKVNYNLIDEDELNEYKISKRKEFEDSIRKRRYLINTYIKYALWEIKQKDIKRCRSIFERALNIDYTNKNLWLKYIEVELTNKNINSARNLLERVVLLLPLENIFWKKYAHLEEILNNFVNARNIYERWVKWKIDETAFLCYINFEERCKEINKCREIFEKLIVNIPKLECFYRFIKFEKKYKNISRARACYEKCIELLPSQFLDQHFYIHFSKFEEENNEYERCRKIYIEALKRLPRENSDILYKNFLQFQKKYSEKEELDQTLLYNERIHFEEALKKTPNDYDIWFNYIKLEEQNINLINKEKSIIRIRELYERAISIIPQICTKKYWKRYIYLWINYSVFEELYADNIDRARKVYSNIFKILSKQNFTFKKIYILYANFEIRQMDIDKVRAIFNHAIENVKNEKIFQEYCDMELRLGNVKECRTIYSKYVETFPFNSKVRVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>V7PK21</accession>
    <name>V7PK21_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anamorsin homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Fe-S cluster assembly protein DRE2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_03805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PK21"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin C-terminal" evidence="10">
        <location>
            <begin position="168"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="9">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="9">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="9">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="9">
        <location>
            <begin position="228"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB58648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="252" mass="28955" checksum="53CEF1336438C6D7" modified="2014-02-19" version="1">MINFSNTLVILNNDVPCELLKKKYSELLIPTISILDFKKKKIYKKYNNIFLYSYQNYSFLLDLNDNILLKIQKYLNKNGILDINLYLNDKNNNSNNRGTNKKDHSKIEDISQILKKLRKECLYNGYINISTEQTTSENGIVINIKAENPDFNKSDDDNNLVSSDEEIYEKCEDKKKVVNRVCDNCTCGKKEKAMNLEKIKINDNEVEYSTENVVSSCGNCYLGDAFRCGSCPYKGLPAFQPGENVKLNLNVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PK22</accession>
    <name>V7PK22_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723:SF6">
        <property type="entry name" value="GLYCINE-ZIPPER-CONTAINING OMPA-LIKE MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723">
        <property type="entry name" value="PROTEIN CBG17025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1447" mass="167086" checksum="D559C80ABFD7E31D" modified="2014-02-19" version="1">MNDDQESDLKLDQSVTSNGLFTVIERKPLSSLENNESFNGNNYGDPLSNSIEGLLKKKEVENNSYNDNICEIYRLNSSQFLNDNCENTISRISYVDDDVSSFYDSEKENELYFDNDISTLGSCYSASSPFKSRNKKSRNSYVRNTRRSNSYDNTYNLYKEKDSKNNDYEEDDDDDKNNKYRRKKDRDYILNYYKKDEKDERHTYNDRLNDNRFNEELIDSKNNNDEKAIRINKNIYRIVNLNKTDSINKENFIKRITKIRKSMIRNTGYDDNKIKRRENGNSNNPDSKELKELDELKDVDENDYIKGLSKIYFNNESGNYANHANHANYNRFSEGHFLKKYKNISRYNSDKRVGYKESDRDREHFIYSNNDRNCEDFENDSDHNYLNSEYKNKNKNKNKFYNHPHNNNEQNGQNEQTEQNNDYNKYIYHEYNNRGNDINENIQYDKNINRNIYRKNVLPQKCEKYEKYGQYERYDEPDHYVGAKIKHYNKNSPSINGNDCKDSYMYRDENGRGENGRGENGRGENGRDENGRYKKGSHIEYGGEKYGSGGDKIYFNRNSKEYYYINERENDSYRYERGNKNYDEYKNNYYKNYSNHNSKKMYNNMEYEYDENENENENMYERGTRGKRFDYDQNNNIEDGNYNQQFRTSLKSKECNDNMYRNNSYNNENDQNDPNEFYYHNRNSEMEHGNNLYKDNIHNYQYDDKIINENKRIDNNDDNICSDMEKGYRYSNDNKMKEEKQAPSFFNNSYNLNDKTQLNNENQQNGHPPNNISQQNGDVISTIPLPTAHLSTTPLPTTPLPTAPLSTTPLPTVPMSIPTIPTVGSVPLATIPVQGAVQGVVPGAVPGVVPSVVPGVVPSAIPSVVPNVVPSAIPSVVPSAVPSAVPSAVPGAVPSAVPSAVPGAVAMQGIPLSSQLPINSGLSIPGQIPINPTEIQSGDQQSQLSQVNPEQPVKRKRGRPKLKKTPDEVQQNENQNNITSYQMGNINNANNNLINDMKHPMYVTTCNNNNNTATTNNNNNNLNPVINTGYNNHLGHTITNHLTIPIEQQIQQAVLNQTQQAVINQTHSQLLNYQINNSGHPLSGQIPESIAHQLSQPIGPSLVHPLVSQIDQHTNNQINNNMNQQVSHPLIQPINHTMNMNVNQKYNHHMYGNSNISNPMNHGMYMLPNIVNNNSLNNNSLNNNNLNNNSFNHNNNYNMNEDQIGQMYNNSFDKENGNILDPNMYYRNLEQNKQNNDHNLCEEDRDENEFAKNNIKYARSTVSESDDKHSDKENKKIHKRRGRPRKSDVESQEDYKNGKNNFGDEYNNKTDRNNDNAQTESREESGYSTFVDENNKTISYRVAYHPADAVWEKISGVKFGPMILTSQSRTTNVILSKKRSIELGNILHNLIYGYIYKGDNVRLTIGKESKNVQSGSSFFLPSYNDCSIHNDDEMGSAKIFLCFVYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLN6</accession>
    <name>V7PLN6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLN6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="291" mass="35281" checksum="A89A5CF9035883F2" modified="2014-02-19" version="1">MENLKYSHNVSIDLLEPLITISVVFICLYMIISTSNPIYYIIKNFIHKTKIFLYEIKDLFTHINYYALIFSSFFIISYYVLHTLNYNNIKPLFSVNYNYYEKILNFDLHDINFIHIFKNSISDNFLVNFLYFCKFFFHIFFINDPHFSKTLFTFFFIYIVLCLYAKRVSSTIFIISILLKVILSGFVLVYFFEKVLKIKYNHCGEDLFSFLFLPFFYITNPYLSAYQYNDISLHPYHGTGLRFYIHILYFFKYIIYNEKYYELKVLITIAIYLIIFAKQVIDKFKVRLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLP1</accession>
    <name>V7PLP1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_03120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="11">
        <location>
            <begin position="81"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="678"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="733"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB59702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1898" mass="226149" checksum="B0C55B4777C3E2FF" modified="2014-02-19" version="1">MRSYIYVCKFKILYQFVEKKNKDKNKICEKEFEQSYKEQIEEIVALNHIYFPIYVENPGHIKKYDIPKDLMSNDIFLKNSKELQSVVVIDMNDEIDTARCFKFCIFFNFDNDFPNYKVTFCYDNKYPYSFPNINICINRILGEQEINFIILSIKKICAKNYGRIMLFDVCIFLNEHINKVYNDGFKNLWEEMRHREYDIDKEGKNKGNYNYEKQDKSCENHIDNNENNNNSKNGSNNYDEEEIFETSDEWDRTGIVEENMNMSGNDNEMTKSIKNNNINKKYPINKDDNNNNNNNDDDNKNYLEQDENRNNELYGSYEYFINMSDVNNLSGFSFINSCTLNKNIKISKKKKYKEKVNNIATVEDELIQKYDLEIFEKKRMVKCEYNNIKNFNIIKKIPINYYKNMLIAKHIIDTNIYIIHTYTILNEIQFLAFYLNHILFCNRGFNLFCNILNDETENQKKKYQRKKCKKNEKMFRAFLYDLGIIRNVASNEEEENSNPETINNIYNVDGNDLFNKKLRNIKTQNSQLFNNNENKNDTKVAPENSYTEIRTKGYATLYNYDKNKKKNNKIIDYNCVNYFCSEYQFYANKMCVVNRQNEKTLYSILKELNIYRLKEIINHYKIVQKMNLKKIITELAKLSKIQHKYLFRYHISWLEKEYVQLNDNMAQQTNVPKIIDFMTDFVLAAIGEFSDVCEKENAFTSHKKSMPNKGGEKKSINVENVINDKKSEQNKNMLILRDNVEKNETDNTTNNNSNNGGDNKKGGSSEDIKSEINLEVNNLDKIKYVEDLISKKDKNIYKVLYVQCEYCKGQLLEKEIENNLFQNNKYLIWNIFRQILEAINYLHKKKIYIKNLNTKNMYIDNDEYGSHIKIINYSVSNIIDYIYFYYYSYIENPDYFNNIFCEFRKYSYDNFSFESLFNYMKKIKNEKTMLNNNVSENFDKKNDFYIHSYNQYFYNFLNKKNPNFEELDIFSLGLILYELWHPPFKTIEDKFYNIKNMIKKRKFSDQFIKNVNNDAVKVLKYILINTINYENNEITRSLEYPQILSLNMNGYKKDGKGISKIKKLKKNNKNILSQPTYIIENKSDSKREDALKDSLNGADNLDVANNLDVADNLDVADNLDVANNLDVANNLDVVNCDHVFDNENVMGNGENIEKITAERLLQSPLIPMVIQRDLFRYFLEKLKNNSPSECNNVINSLLYNTNNCNNKNSNMSNHIYSKKYLFETNKNSHIYTNTRTYKYDIINSYIFEYFNDVLSKKFCTYNQPLVFQRVIKREDPNFDNIIKKIELKNGKKSYIYTKKQGKYGNKIKKKLYNDSFDSISKGIMSKKKKKKKKNEYITYSFDEHRPKNNNIFKTKDIKRINKNGKKSFVETDQEHDVDVYCNSFITETKKDENYSDKIMYDILNRFNNKLELIDKNNKLLYMPIYLSAGHINTFYNFPNNKNLISYFTFFQNYFIQNNKQKIAKRENSILYTNMIIDNGHTIKSSHNIKCHVFFKDAKIESVNLGSNVYEGKSGKDGKDGEDGDMYSEINIFFCIYQLIILYNVLDILQHFEWYINKLIVRWSFSNFLFIIIKDMFSIDCNDTVYYIYTKLEEGNISLKKLKKLLYCLDINYNEHILKIMYSLIQNRDNRNINNLSKDNLLYTMKKINKMYELKNHKNKSYINYIITNIIFLNNIFHHFNQNSNYIFVWDLFMNKYKQLFNFSFVYNILYFSENDEKLLSLGGVITNEFDNMNKINTKKSYNILFEIFVDNISTIIFKNIFKLKNENTFDFHSPSVVITTKTYKLLVHAFSLYNSLIQNNIKCECKISPIVETSKFEQELLKYNHINMHVQINHKVNTNPVVYFDYCENVSESITQNISGQNNISIIYSTNILRLNIKKNFENEPSVINYIKQLYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLP4</accession>
    <name>V7PLP4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLP4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1157" mass="125573" checksum="7ED35403F21BC112" modified="2014-02-19" version="1">MPKDMCMIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSGPTDGQGGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLP6</accession>
    <name>V7PLP6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation TFIID-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_03122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLP6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="126"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB59707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35616" checksum="C0785833111DF244" modified="2014-02-19" version="1">MEHVSKKIKLDNNESKNIYINNSNNMSVHNISMNAILCTSLNLDNIYKHFSNCVYNPREFKCMRVDVPVSLNTVNKYIDYIKNKEKIQTEQTEQTEQTNLVTKNNKNEICMPVENNSNKDTSTQLFNKKSNNNDNIEHNNDNIEHNNYGSSGIKHNDEIQNFEEKNDEVQNFEEKNDEIQKFEEKNDEIQKFEEKNDEDDHYTTSEKLVINVSIFSNGKIICTGNNSIEACKIAMKKVEKKLKQLNFKNIKLKKIAITNILAVYNVGFSIVLPLFAQYYKSVSSFTYLNKTITCTRNSLLLLLHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLQ0</accession>
    <name>V7PLQ0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLQ0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="443" mass="53298" checksum="9241945B34A6C891" modified="2014-02-19" version="1">MFKRNQTVLDKLKKLNKKKNIWFIEGYAKNVFNSDSFFNVIGLEEVEEIDIKSCDIIKKINFNKLLNKKYVYKNQEDIKNNYRIVSIQRVKRFALLYKKCCNNNHNYNNICDNKGNYMNEFIKNCTCISNMKKSYVICIYTYVVFSIHDIKENKYYMIINSLNNNDEGIFYELKELNIENTKPSLKLYTPNKGTVKNSNVISLTKKNYILKDVTNNVEDNNKKSNSLSFNIFNIYFKSLFNLVNNFEDILKKIIFSGKELQPEIFILYEDKNIFLKKKSYLEYIKLFFLKSDEYTDLYQNIFKNNKWYKLYIQNCAQRQSSYILRCTTINEKKFRNLLKFVKNENNNNYNYHNNYSNDERIFFSYCKILFEKYDEECLKTKHKTKSVINNDENYNHKSVYINIDTNNNNLRNKELLILKKQKDTFLFSMAKYLINNLISSIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLQ1</accession>
    <name>V7PLQ1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLQ1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1150" mass="124960" checksum="98498CC4E275B030" modified="2014-02-19" version="1">MPKDMCMIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLQ7</accession>
    <name>V7PLQ7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLQ7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="849"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1144" mass="124226" checksum="5F7DFA45302ECD27" modified="2014-02-19" version="1">MIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSGPTDGQGGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLR6</accession>
    <name>V7PLR6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin NUP100/NSP100</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1070"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1358"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1754" mass="196063" checksum="10EEEBC6692053D0" modified="2014-02-19" version="1">MYMQNSSSNNVFGSYNNQGNNLNKGLFGNAGNPSSLTNTNTSNLFGGSKPQQTNNMMVNKNLFSMGTTTSGLDGNKSIYDSMNNQSNLGNKNLFGTSTVNNNSMQSGGGMVRNNLFMNTNNQNNLNMKNIFDSGSNLNNAQGTNLSNKGLFGGLQQNNQSSSGGNLFGNLSSQTNSGSIYSGLSSGANQNKGTGLFGTSGNTNQVSSTSSLFGGTSTMGQNKLGGVFGNLQSTDQNAQNSGNTTNSLFGGMSGNQLKPMSTGSNLFGGMSTNTTTNTGTSNLFGNNNATSGMNQNKPSSNIFGSLSSTTQPTGTTTSGSSTTGNIFGSTQTANQGMGSNVFGSSMGMNQNKFGNIFGGTSTNQSNTMSSTFGNTGLGTSGISSTSALGSGTNTSTGLGGGLGISSSGIGGTGTNTGMNISNLTNTTGGTTTGISTSSGSSNLFGGLSSTSNTNTMSLGDNKNLFGSKPGFSLGTGTNISGQSSTNLGLGTNLGSGLLNPSMNTTTSSVLGTNLGSSSTGSTNLLTGLTGGIGSSSTLGLGTTTSPTIGLSSSSSNILGSTNNVLNNTSLSSNLLSSGSGMNQTGISFLGDKNLIGGNQGNMQNNLLTVDGKDKSNDLLTNKLNINKESSENLIKTTKFDDDLIISKKKEDIFNKAYDDENDISNDEMNLIKNQDGTFYNYINLIINDNINDIQKTTFSLLNDHDSLMWDNFKSSIFKNFVDYLVNFKQKKNQKIIKSNVLDLDQHEFQILIWLYNINSYKIDFIPFKSFYYLLLSDTNLNYSKMFISNSDKSILPRNFVEINDHYYMNYKSYFFKSQINKHHDNYSTLNRDGIGNSSNGGVSGNSISIGMNNSVLDIDSIYKQILKDILNSLLNMNLSITKENIKKKEKEEYYENGDINNKNNGNCGSSYIYENLLLNYLFGTLQHLHDKFYKLEISNYLSKDLNQIDEYFVDTKSNEIFSYCYDNFYKNEMDKENCTIHFFFYLVNIMFRCGNYIGLIQIIKNDEFIKNLNIDSYLNDFIILLIRILLLIYNQSNEISIFENMKIDIDCSDIFKKKIHMSNLINFFHSILYLCSNNIYAYDLLCILFSDIFYKKGNMYTNREKKIEMKNIFYYVQKKKRNSNYVDNNSDRNSSNEDNYDSGGDNNNIGRGSNSTNINKGGKGKGNERKGFFLDVFTNMLHKSKKSKDDEDEPFGTMEINEEIEKLNRESMNTSNTEMLGITNKYSYNFEYCNIETSIWIELSLFLSKNFDLYGSKFQENFDILDTNLSYYNYDDDNNAFLNDTKHRRDMINSKIEELFISISNCIINENREYFSVCSKLRVDDVINNFIIVDGKISEKVKSNVFKVLRTNFLLYIKLFYYLLLVGNIYVTVGFLSCISNNIQRILLVLTIFLHKNNVFENSKLNNIKIKTLGFLKLKTDNSTILYNSKDINDNVSTGSDNMNLILLSMNNIDIPFDYFLLRNNNINILLKASYLLNLKTNISIKLLKSIVQENQGILLNESIIGHINNDGNIFYGKLHDFLFLFKNKVKSRRNIKCFFLMYYVLYKKKFYNSNILRKIRKDIDNEYHYKCRNFKFVQNKNINTLNKISLDNSIINVHSSILYKISQFYSILAYFANQRKNYIVSFICYYILNDEQSAINSLLRIYNDELIYYYFNNEKEYGYIRKCAFRFYHLAKNMWPSNVKLESIEQKSYLILSILFMKKKMFEEAFAIFSLALIPDNMLEKLSTADYYNIDLSSNFLVTLRELCKKNYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLS0</accession>
    <name>V7PLS0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication factor A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLS0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication factor A C-terminal" evidence="2">
        <location>
            <begin position="94"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="274" mass="31931" checksum="44816C925F1ACA19" modified="2014-02-19" version="1">MKNGTFGVTSSIEKVENLNDELKEKCLGISEWYNNNGKYEQFTNMKNILSNDVIQTPDKHYALSDVNDVLTKISGTYTLVGRIKRIYWKSKENEHRFYYPACTKCKKKLLSSGQDNTQGGDYDNSNFNNEENCVYSCMNCDENNVKPFYNYTFNFLFMDFSGSITLRAFSDEGFNLLGKKAEELKGLDEDSLDYLFNYDFLYKEYKVVVRVSQKIYNGIERVNFTAMRIFPQKYSDISYLLNEIQLLIPSDNNTTKNNKRSLNDNSYDAKKQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLS3</accession>
    <name>V7PLS3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLS3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="287"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="423" mass="49499" checksum="DBFCA88C0FD3B39C" modified="2014-02-19" version="1">MVKKFQQNSTKNVVINPTEMRNPDGSNIERKTDKEEEDNDDKNRDNKDVIENSDEEGDEEEYEEEDEEEDEEDEEEDEEEEEDEEEEEEEDEEEDEEEDDDEDNEKEEKEDVKGGETKPEGEEEEKEKEHDDAKDEEDKEHSDTQNEEEDKEHSDAKNEEENKEHSDTQNEEEDKEHSDTKDEDDKEKIKLNNKDNSSEHDDDEKTSNNEKSVMDDEDEQSSVAKTQKSNESVCSEYGDIKKNDRLFASLNDANSPNKLFSEYVGTLNIFGGKGLDLEKLQKNIDKKKKVIDEKKDIKMIEEENPFENEEIIYSENTIKINKFVKKDGKQEWSGYLPVKIQIMKNKENDKYRILCFQKGSGRLFLNTDIFEGFKIIPSKKLSALFNGRDIGNEKIITQYIVTFISSSSRDDFISKINDISKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLS5</accession>
    <name>V7PLS5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GDP-fucose protein O-fucosyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLS5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="403" mass="48552" checksum="2803F93A82B366F3" modified="2014-02-19" version="1">MSLVIYQLNKRDKEYIYYLVLPPWCYLSHWTNKRHDNLEWNIFLNIDIIKNVIPIIEFSDYKKLYGDVTDFIISFKYLLDSYGQKGKYYHVLPFDKCYIENYKFKIICENCDYKYSVTYSGNCTHIKGKNTLCYGDYIVTSYLVNFVVHKLFYIHNINSILIKNSSVVLVPFPTELFENNIEDILLFNERLIYNGNNYIKEILKNSNYISCHLRYSDFKKITSYDIPSVQLAIFKLLYIMFMNNKEKIFISTDEKKNVQYIINKHFKQFKHFFHFYENKDNYHEGQVAIIEQWICANSSIFVGNIFSRFTMHIIWERYLITKGNENQNLDLCGYSINNNEQLKNRYKKIQHIYDHHAIEKLNDIYNTYSEIDKKYIITLCFGFPSHLPNNLSIYRKKYIPFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLT5</accession>
    <name>V7PLT5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_02681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant tobamovirus multiplication TOM1 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLT5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009457">
        <property type="entry name" value="THH1/TOM1/TOM3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06454">
        <property type="entry name" value="THH1_TOM1-3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="7">
        <location>
            <begin position="65"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB60389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="278" mass="33046" checksum="A051D9AED6050D62" modified="2014-02-19" version="1">MVHVYYDKTYKYIQQENDFFSILFVFHFCAARILSTTILTYLDIRDDAIDYNTLLLFPNFYFLLILLKTIPTYFFLSSFTIIILFWSQVYYSSMLVTSQHLKSYYIYINFSGYIINLLFAIIEYLLSSFKNYIYFNFIFESLVDYSIAISFLYYGVKVTSKLKEKNKGISQKSRITQRILSLAIVMFVILSLKGLYSFWCFTNDGELYKSQYDVPTYDALIYFISECIPSIFIIYTFQSNKDKNPMSFEYATPLCSQVFDPYDYKMKKKANKPLIKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLT6</accession>
    <name>V7PLT6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_03151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLT6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB59752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="627" mass="74298" checksum="12E3F449376B1816" modified="2014-02-19" version="1">MIDNSENHASGYEMLIEMPNTTISSNNNNEERKYYEIYGNNKINDKDIYDNSKDRNEGEFEFGSPVNYTIGNKNSSEKYCYNINEKKKIETDIKYCGYFFISLIFLLFFILYYIYYGNYSRILYGTNYNGLICGKDLKSFKYLYYPLSPKTSKLEILNKYPKCLESCPTSDFSNKNKTDEDNLYGEKKKKNFFEENFFFPFKNNGDKNKGKIIDKNGNIETSVIYTDYTKGPNNNLYVEYLLNSKYYDTVNIMNICYPRDKMLREKVINVVFTNRYKIFVNLFSLHNSFFFVFLFIIVSILLSFLYIASLYYFPKFTFYIFIIFYLISIFFIPIYFVHNHLYLIFDPIKGSFFSYHYLISILTSFIMIIHAVISLIIFYIYKNTYKYTSKLIAITLKFIHDISNIIYAPIIISFVSILFFCVWIYLYVQIITSGMSYDQKLDLDLDSNGSSKILSLQKMFYYFKSSYLFSILWVCIYFFICEMLQSLNQFTICHLGTVWYFSDKKKSECNQNVVEEMKTIMKYHFGTIVLSSFINLATKHLRVLFFWINKTLSLPFFFNELIYNIKERFHFILNPMSKIVDMYTTSAYCEMSMTLYPYVTSCHISSKKLTNSTSPAAALHGVINKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLU1</accession>
    <name>V7PLU1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLU1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="480" mass="56745" checksum="57B3A5B9E4A0AE59" modified="2014-02-19" version="1">MARMRAVFLFVIITIFIGDIIGEKYKNIKKYKIVRSYICNQYNSDNKFYTENGKKKILNKYRIKYNTKIKRLNVLLNIKEINLIKNVNFLSSINMVTSLSSIFIFMHILNYFKLINNTHRNALLEITDKICSKIFLFNTINDIINTNFQKNIPKYFIIGLFSITQFIFHTLFSNVMACLFYSRDQQNGEKIIEKKNITKCEDNNKENNYLLEKSLSKSNEVSNYIKTKNEDILNKNYHNGSLRNDINNSKQIETSEIERKNNMNNVSLLKHLCTLSHTGLIPMYVFNYMLKKLNYKNDNINIMINFYNLFNSILSKIYVNYFIKNSNIENSGDSSSPDKKINKWCTPLALLNSIFNNSFSYFLLISIFLKFIDKTNTIYENSLKKVLLMFNNILPPSILIIISNILYDGLKENSKIPLKDLFFILNNKYVLIPSFFFVLSHLNDYFKVFEVAYYYHHHHDIIIIIIFLHFLFHKDISTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLU3</accession>
    <name>V7PLU3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLU3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="112" mass="13583" checksum="FB1B17BB884E3169" modified="2014-02-19" version="1">MCAYIILIIYNVILLYLFINIYIVFLVFDKIDRGELKKEIIAHSKKVSLDLNDEQIKSIENKLNEFFSYMKWTNIRINLGKKKFKHKLKRLSLREKEGINEEVNMEYFIYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLV0</accession>
    <name>V7PLV0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HID1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLV0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="103878" checksum="A24142A95BAD711B" modified="2014-02-19" version="1">MGQSNAKHIYTIFDKSNPKNFYETDFYSELLYSDNCLKQCDFYFVNHIIDNVENVTLFFKFLITTLERVLTGEDDKYINDCNVCIKICLCIFPVLQYNYKKKEIFNLMWKENNFEKLVCTNYVCNNILILHIFNFLLIILFTENISINSRNKNGQNNYEHRNNIVLAKNTIDIYKLWLVKLVTYEDNVETSNIITTNNKNTIFTNSINEYNINNKLNDENKNKEFSENKQTQNDDDNDEMNKTEEWSNKNNALGNDNNKYIFTNDIKCVEYCQVNDRNDNEKDNIKYNNSIDLNLINNRINILKCLLILLSSYMYNNNNNYLEEKNMCLYLFTSGDIYFSSNFFISLLSVIYDNEFNYFSFYFYNDTYLEFYNLCIHILNILIDFNPFVLQNNKKVHYISSALDYFFSVKKIASKPKREATNGEVAKNREDTGKNSDQASASQLKSYSHFDSIICSYSSEESYDSSEENSSKQYKGKEAICNIKRALKIKRNYLSISGDNNNSVNNDDNDYYEYIKNSKKIKYLQTRNIFLVMLRNLELNSIKYIYKGVLNMLISYKLYFENYEEDIFYINNYLCLFWNLMDNNKLLVNYVKNHNSSVFLFYILYILICFNNKRKKEMQLFSDIKKNEPLNGGSRSFNNNGNDVKAENLNNEKNFYNNEKFNISKKCDEFNIRKIDGLIYICLFIILKLSSSSIVCKNLNQKYNQKIKINSLIKNVYQFETYVDFLIYALCSLINDNIYFLKFERIIDMSIIILTNISVYIKSMSIYSCECIINILKKILKKEWILSSQHHHYALFLLLDFINNILSHNLSDNYNLVYTIIKNRDVFISINNLDVSLKDCFISTPNLDKGMFCLKLCVLRLLLLFIISLFIFFSLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM05</accession>
    <name>V7PM05_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">YYC_03206</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="5"/>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM05"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0140">cGMP</keyword>
    <keyword evidence="16" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 29" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 22 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="27">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="27">
        <location>
            <begin position="107"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="27">
        <location>
            <begin position="226"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="27">
        <location>
            <begin position="349"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="472"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="28">
        <location>
            <begin position="730"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22 23">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="ETB59827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="783" mass="89743" checksum="46DF3E3751C7FBB5" modified="2014-02-19" version="1">MRIYAHIYIFLFFRISMISSCEGSYFFIINSGKFDVYVNDKKVKTLTKGSSFGEAALIHNTQRSATIKAGTNGTLWGVQRSTFRATLKQLSNRNFNENRSFIDSVSVFDMLTEAQKNMITNACVIQNFKPGETIVKQGDYGDVLYILKDGKATVYINDEEIRVLEKGSYFGERALLYDEPRSATIIAKEVTSCASICRKLLNVVLGNLQVVLFRNIMTEALQQSEIFKQISPDQLNDLADTAIVRDYPANYNILHKDKIKSVKYIIVLEGKVELFLDDESIGILTRGKSFGDQYVLNQKQKFKHTLKSLEVCKIALITESCLADCLGNNNIDASIDYNNKKSIIKKMYIFRYLTDKQCNLLIEAFKTTRYEEGDYIIQEGEVGSRFYIIKTGEVEIVKNNKRLRTLGKNDYFGERALIYDEPRTASVISTVNNLECWYVDKSVFLQIIEGPMLAHLEERIKMQDTKVEMSELLTERIIGRGTFGIVKLVLHEPTKIRYALKCVSKKSIIELNQQNNIKLEREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSRSQAQFYLGSIILAIEYLHERSIVYRDLKPENILLDKQGYVKLIDFGCAKKIHGRSYTLVGTPHYMAPEVILGKGYGCTVDIWAFGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVTDTDSINLIKRLLCRLPQGRIGCSINGFKDIKENPFFADFDWDRLAGRLLEPPLISKSETYAEDIDVKQIEQEEEDNANTEIDDENWDIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM14</accession>
    <name>V7PM14_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM14"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="181"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="27065" checksum="5F45D075C1CE8228" modified="2014-02-19" version="1">MLKIMKEYKDYFEKEFIKNCNLENNINLMENLEIKEDNDYNEDVFIKNQKSFHIYDFFNLSLLFPIKILNQNGKSIIQLISEDNTPNDLNMIQTILKNIEQTEMDKLRFFHIENIIYELIDELIRQIAVDCPKRGFSLIVINNEIKKNIDYYKRLIEIIEHNNNMNTEKFNEMQRKYSIMIEQLSVEENNLKEKLADIQNELELLRNTNKKKAQENRNKMEIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM18</accession>
    <name>V7PM18_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM18"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB59842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="882" mass="102980" checksum="AC2C435EB024C5BA" modified="2014-02-19" version="1">MEVLPAGFSDFRSREYWNNFFQAFDKKNFEWYGSYKDIKNIVYECIRKRLNYCDGENGDIGVISPQEVEEGKQIFKNERVDKNCLLVNIGCGNSNLSYEFFEDGFDSIINIDYSDVVINKMKNKFGKMMEFINIDINNKECFENFLESLDIEKKKKKKNFKIFFDKAFLDAYISGDDSEEEVCKNNAKNYFESIFKYMNEGDIFIIITLAQYYIIKEVVRNIYNADIKLDVNPFLIKKNTNEFRYHPFVFSFYKTNIKLKDYTMKLCNFENNDYKIISLWKLPHEIRQIRDNLNLHSFKKGKRIILDIFNQNINKCEYNIIVYDSNVLKTVYNTVVIVVPFGYEFHSLYSTSEGNEELATKIKAKRLLLVMRSNFIINEFKIAHENNKSIANCESVKGGEISNTLESNEKREDNSNHLLNGNENTKNVQNSKNSLVSENKISNSNSSEFSAEASNASNLYDGILENQDSVSILLKSVKNELNKIINELALPNSKNFPIMALNEDIKNYKIICHEKSNYCSNIIIRDVLVTDEFISDNFGASEDNKTKKNGKNKKKLTPKNNTQNASNSEKGNDNVVCEEKNNKITHDDAKKLAIELIKKNTEEKKIYFQNKEIYKRQMIFSYDPLTVQSEIIYTKEKKKTNKLNDHEKIVFEYIESSSQYHVNFCCTFFLFILNNCYAKDNNLINICILGGGTNVLSNIIKSIFCDFNLYFNIVEIDETVQKLYKFFYDKEEISNDKHVTNYIINDSYEYIKNFNQPKYYDIIFVDMNNSENSYLNINGQKLYITCPHIGLLNKDVITDIKNILNEKGVLVINLLTRDNNAKKYVYQFLKDLFSSVISISSANKEINEVLVCSPNDIKEENIFSFKMNIMKWVLVLFYIVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM19</accession>
    <name>V7PM19_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM19"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="25038" checksum="34390740D4F23139" modified="2014-02-19" version="1">MLKIMKEYKDYFEKEFIKNCNLENNINLMENLEIKEDNDYNEDVFIKNQKSFHIYDFFNLSLLFPIKILNQNGKSIIQLISEDNTPNDLNMIQTILKNIEQTEMDKLRFFHIENIIYELIDELIRQIAVDCPKRGFSLIVINNEIKKNIDYYKRLIEIIEHNNNMNTEKFNEMQRKYSIMIEQLSVEENNLKEKLADIQNELELLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM32</accession>
    <name>V7PM32_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoadherence-linked asexual protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM32"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020035">
        <property type="term" value="P:adhesion of symbiont to microvasculature"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005553">
        <property type="entry name" value="CLAG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03805">
        <property type="entry name" value="CLAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1083" mass="129896" checksum="EC23EAAD6D8C6E21" modified="2014-02-19" version="1">MAFKHFNKYFVNGDLKFYTWGMILQFTPEDRFKALDLICDDTYPKKNKINKKNTIIKSRITGSSQDCSVLEFLIHQYNIYQIELFKKASILNLNMQLFLDTDSLKQNFFNFMCKKNNECNIYKGPHFKQENDDKYDFIDNNQKFSDYFIENIEKNNPYSVYTNYYYFTKYYNEFNQDQVIYVHILNLIGILSGSPSAFVSSLYLPGYYNAIQLSYIESQEIAELYNNLVKCYKVCYSRRSSAFKNKIKNIFTVRHYDSSQCGICEGTMFYINNRTQDTTPMLQRYYNYVTQILNVSVLSNLTDKMHIYESYDNFLMHDLNWFTFLFLFRMTTYQDIHNNTISNAMFLNLHNETKPKRTMVTFHWYPSYLKKFIIHYIRKNKSISLLNELESKVKKETIEKMKNSIRFVMHINSILQLDFFYYLNEKPLKNNHPYGLTMLIENKFKDWFMNYLTGFTMVNYDDNKGRYKLPEKREKREFLASKLKMWTIYVKKIITDAYVQNFNQKHVINLYKYHDIFNINNKIMVMRDSYELYIKNFDKVFFTGDILIYNKFFSSTPKIQILKDRALYYVHGLWGNQLNYYKFGVLYAYTINKKLLKEIVEELHTIYVTNKNVFNEVSFMQTVRLLFKKIQHSFFSHRRNDAVSMNNIFFFNVRNNYSKLPKEERYQEIHESLASRFFEKTLFSIFHIMFIIKISKHVDRLDTIYGKANMLRIIVHEEPHLRLEYLYNSSMVDSLLNVFFPLYIKKPTVQLKYGKTFILANMFKLTSELFAIYNLNNLSMLCEYQAITGANYYSFKKLNDFIDRKFVPIILFGYYKKLANEINNPGQNRFVALRERAVDDGAIMLTLLYKSLYMAGNILYRNGAFFPNHLPEELQKQIDWIPLDKIENKPSAFYFDFQALFATVHGVCLKSFIYTLSVYFCFFDYSVFLFRLTTRIFDRFITVIDTYINAYIRSMFNRCTIDVFLKALSKIYDETKKEGYYREIIESRIYSKDYCNNDTECEFPQANTQIIEPIDISGSHYGTSFFYKDYNIDFEELDENELFLNDKSIINYESDLNFYQNDIDFTNKPFNLCSTNEQHKPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM37</accession>
    <name>V7PM37_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-seryl-tRNA(Sec) kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM37"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052648">
        <property type="entry name" value="Ser-tRNA(Sec)_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873:SF0">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="70033" checksum="71A116113C836D2A" modified="2014-02-19" version="1">MNFILLFYGPPCSGKDTLIRFLIKKKKKILFFIYLLYNLKEPYISYKYSYEQKFFIQLIKYCNKINKHFKLNNKYRIRKINHLSFFSLINLYKTFFITLSDSTFHSNFQTSLNTIYAKLKKVKKKKKINISSHTHSNSNNHSHKNDKINVTNVCIKISRKKIINNVTKPKTFFIFYKKFIKQIKYFRHFLSKCKTSIHNISTDSIEKQFYSTQNEKKSEKKYEKKYEKKSEKKCEKKNIAVVTDKIIIFEKQNYKTKIYYPIIKKRCLKNKLFFLSKAKENKNIKPTLFNQKKYWKIARKIAYLYCSHLINAKKNAKTDTKKKTKIGTKKKTKKGASTSTQNGPRLKHDQNKIIILNDTFHFPSMRKKYYLLSKKYNSLYIQTFLNTPVKLCIQLNINRNKFKYISKETIIKNYLYHRKYAVALKNVPKNEPKNEPKNEPKNEQKIINFVKATRKWQANAISIQVNRLENKNKLTDLLFFIYKYFPIFIKEINKKKTVTKKENHNPVIQTNALEIINKTANKIIHEKLKSVPNDQKNAYAQKYRLIKLQLLKGNLFFSILSFAFFNLYSVISLHFRIFLILQNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM39</accession>
    <name>V7PM39_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM39"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="573" mass="68944" checksum="26AA89FA8025DAC9" modified="2014-02-19" version="1">MNILCYVIFKKFSYEYKNDNKNKDLLVFLKKIFPFEFQNFQDVYNKRWSNDFTSPENIIKQQDNVEIVKEVYNVDDNKLESDGINRKTNNTLNISDKGKDENTLNHENKYANTSNIKNIANSSSICLNLYNNNNVLNHKEKNGMNIRCMSNNMENVLIKTEKIDDIDNNVNHQSDDDNCYDSTEHNMSIGENNKEYNLEELKKSVKKEFIYDDYIFKNKDIQKIIKNLFDEKRFDYRLRFRSILSQTLNNEEYKKYCDLREKLFKYKKKKFMKWISQFTKINLLDLYAVNFFIFLFLDRLYLIIETYIRLNYCGKEYPHESSDNFLEDINEFQTFNNILNIFGDANPTEQENTLRNGFNNNAKNEQHIQKFKETYNNIIKEKFSNFFYSIELIYNVDVYNFKIKNKIKFEQLINTDISTYINETNVYDIINYDKNVNSDPWKALANFALLHNRNLKLEKFDCFSLFLIVRFKFYLEEFKENANIDYIYKTVKEEFDKVQNYLESQNGLNDVSKDIENKLSINETNEENQNDENEHDENSPNDFEINHLVNLYLDLQKELKKVHFLLLKENIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM41</accession>
    <name>V7PM41_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_03237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1408"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="407"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="757"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="803"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1128"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1200"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="827"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="867"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1075"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1205"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB59862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1516" mass="179288" checksum="51EB7DA2C552FFE1" modified="2014-02-19" version="1">MKRRQKNCIGLSNCSFDQFKKGVEFLRETDAILDDDIFIILKRVCSFFFFCFKNDDFEYLLKCFDKGNKEGSKSIINSNKSWTDNNSTCSKNNVLDLKNDEIYWDYKFSKGDFIIIKNINRLLLNKLVDNYVGYSWLCLIVSEYMNNLDMFTNNLCDNEKKEKEDEENEIWFKYQIYKNFKQIEELNQINKIEYNNIQNNPEKYKEEELNNRKTNYVNYLHCYYGNIFSSSCYDKKNRDSHSISNTNPNISNSYNDPINNNTDIFYLDDPNDRFNWIMSSDNDNDDELVKSNSKSEKKHLYNNYYKSSFYYEENKLENENLNNILYSNKMYNNAEKNKKRKLIGNKIYQNEQKEKAGNFEIYKNKNYSNEREVETGSYICSNENDEINEFSDGNPELGQSINFSENFVQPHQEYSEKKYSRKYKSEERIEKEDGVSDEDAESDGDARSDEDEGSEIYHSRNSDDSGNDHDDESLHYLYKALCDYLSTKYETNKLQKYMDEYRDTHSWKPPPFYWKILKNKYVAKEVLKLYEDRHLDPFLSCLYEDFVNRYYFELKGSNNNSSNSNGYGNNSNNSSGNNDSNSITTYTSNFNVFTLRISEEICKFLLLKEPEEEEEVLNICKNICISENSYIYTQLILEYIYRNNNDNSMRRLSQYLCLYIIYNDINIHNICNNYFHNVIENEVSISYLIFKINNLHNYTSLYNTFKNIYMTRNKGFMNINNTEIVNLHNNILQVLRIFNGNKLLLFDSTYLFDNNNNNNSGYKSGRKKPAINKSPNHNKDNDGSSEVYSHSVSVFDYNSNFSNKNRSNLEDENNRNRFGSGSEISGEEVASSEMSSSARMSGEISDSEVGKEEINDDERVSSVEMSGFTSQCGDENTECNGSSASKEKGSKMIADFSSWKNGNTTISSLVDSEELRFGRIEDINNNMIDEKINKDVPRLNKIKSDVSEFLLPSASQFGNRDYRHNKEFLRINIYAEKIPLIHLRDIFFLNNIINIYATNNELFNNNMYKIYGRVLIFLTTYSPYEYVYNHYYSSFFKGKKNSSKKYSTSYFNIYDDTISIIDEDENSETDEEGSASYNTESENTQITSNYDKGIKMSDEDDPDDDIIHSLGKDNYEIEKKSKRKFKEFSEIKNNQESKKHKLKNSDTKEDGKDVCADKEKEVRQTDKNNELVLKISNDNNSKIVNDDNISKKITIGNTYNQINDSTKEDNIKPRPNNEENVNDQKSPSENSVVKNSCINANDLFELRTEVMSCDEVKSHIFKNVKSKKKLKVNKMNKKKKHYFYKLFYKFRLTYNNFIKFVQTEIFHIYNIMHSNTYSDSTKDKLLLGKINSNLSASIIYKYVYNNIYKHINSNEVNLIYTKFIILKHIVDKYPQKRFLTLYFFKELYIFIIEKEKTLQEFSELRENIILFFVYMIRFENMFFYVINVIKKMIYLLDKSLIRLFIVKTLTYCAPPYNFKFCKYILNFIYLVLKKEGIYYKNEFKKVINKFLDDVEQVHEMYQSSKTKEVKIKKKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM43</accession>
    <name>V7PM43_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM43"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="568"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB59413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="971" mass="116202" checksum="43C59F4DDA21DF50" modified="2014-02-19" version="1">MDQHQNYSNEKNINNEKIRKDPNFSEKLLKNLRDNIFENNNCINMNSSENSSFLQTNLEKNTNFYINESEKFRDNQINKNCTNSIKREHNVDGENVPISSCNIDINDNSSDNNFKVLEKLHNGDIEHTNFVNDQLDNSKQNVCGNIKRCENGNAENVEKIEKSGSTENVEKNGSMENVEKNGSMENKCTFKMEEYISNKSVEGNTFKENKDQICEDSKRCEENENPNLETKRKNEHSFSKEIKALNPPKNVYEYNHNVIYHELYIELLEVNKNLQNEIKNLEKIIEMQKELIKSKEGDIFENNNMIEKRKMSSKSFVNNNYFLNFFNKKNKTSKKKDDEQGKADNEEDNEIFEKDEGLAESNYNYNQQRKGSMTRFQNMPFSFFSDKSSKQKKQKSTESINTINLSIQEKDNEKQKNKRNIGTPKWTKQFDYKWIKSINNSNSFQECEFIYNDDMKKNDEIDNDENSDINNKYMKLALRENEYVEFYDNDDSCTFDNSNNKMNKKKSYTFFKDKSNSKEIEKYRDCDYKDINTIKEITLIKYWYNKIIPLINDEKKKYTLIELIMMNYMPQVIREYFWKENINNKLNITDYFVKVLIKNANFIQIYIYINNKQYYNIFSRYFKNLINLEKSSINIVPSLLTENCFVDENELINTVKESELYKKMITEKIFIEDDEEISIDIKENGKVTCSEKSIKMNTELNSISSNLNKDEKCDKENNKKDKIEMKNFEHLNINILQRYSIHKFFYQILIDLDRTMYIIKKNQEYYHRTNIDKDNFLFDLNIHDIKKNLNKLLQMYVIFKPELGYIQGMSYIALVFVLHCKLEKAFIHFANFMEYKNMRNLYSFNKQEIKIFLFTIKEILTKKNIDVYKEIVKHYNIDNIFIQWAYTMFLTCLPFHIFIRTFDIYTFNEKIIFETIICIFTYFNKFHSTENVDTMIKNLSSFSLNMNIQVSPFIYAYKCVHILFLANFDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM44</accession>
    <name>V7PM44_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM44"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="266"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB60025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="363" mass="42602" checksum="B5910D0CB69BC22A" modified="2014-02-19" version="1">MLNNVGGFICPLFRNVYNMIASCFNLVSSYILSSCNKNSFIVYFEEKYGKNHVEFFNGTLKDAINKSQKEDKLLLLYLHIDNDESEYFCKNIYTNIEIISFFENNCILYAQDISKHPFIELHDKINIYMFPQISILLTYASNIKELSVIYGQPSVNDIIQSIIECIEKADAEKKKAEKIKAEKIKAEKNILAGRNVSETVYRDRLLREEQDREYQEALKKDKAILEEKKKKENEKLLKIEKKKNYIKDIKNKRNEKSKKFPLNIESNDKITKILLRLPNGIKVQNHFSNNHTLRDIYDWAECCDILESDQTKKQNIHIPYKFELICGHTKYVLKNSTDPIKDFDLYPNAVLNMKSLDQSDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM56</accession>
    <name>V7PM56_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM56"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1151" mass="124867" checksum="4717A24FC209EBD4" modified="2014-02-19" version="1">MIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSGPTDGQGGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM58</accession>
    <name>V7PM58_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BOP1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM58"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="8">
        <location>
            <begin position="126"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB59428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="627" mass="74169" checksum="317B6B2D2EDCE7A4" modified="2014-02-19" version="1">MKSQKNNEKTKTKTETQSNFEENDGNAEKSAKLDSEKTNKHTMLNTAKKKKKKVETKKKKKMGENEEKKEKKEKGKKEEKGKKEEKGKKERKIKKKNHNIYINEEIDESDDEYNLNTIGNIDLKYYDDLDIIGYDIDGKKIEKTNENMIDDFIESKKDVDAWRKIKDKKNNRVVTLTDADLEIIRKIRENSVAKYIDESSYIYENDREEYKLPTNFNVNKNNKVSKGEKKKILKLMKYLIDKEKHPEKYKNNQNSNQEELTLYDMWNNKIYDEYSNMNEINLPNILPGHKYSYNPPPELIYTNSDEKNILKNNKDAFIPKNWEKITNIEYYKKTYYDLYQRCLDIYLCSRSVKSVLDIKKEDLLPKLPTTQSLKPYPQYPFIKYNINDKIKNEDNGHNYICLNENDHIFYVIKNNKLYIFDILTSYNIDVIDLESYFNSALSPNKNDKQNNKNLMIKINKTYSLLAISWGNVIILLQYESYIPPIKSNTIDVEQIYYDIKKRKSDSVNDTSKNDEHNESSKDGAEFETDQDDDNQIFEDDWDDEDVSDDENGENDESDENGENGENDESDNNLKKKKNSDLSKNMIYCKTKELINSFNQNFKNTDEYISSSDLDIKWIKIPSNNKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM61</accession>
    <name>V7PM61_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PM61"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="849"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1144" mass="124254" checksum="1E6274955DAEC24C" modified="2014-02-19" version="1">MIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PM77</accession>
    <name>V7PM77_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1610"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1615"/>
            <end position="1638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1996" mass="234543" checksum="82C2A7C9521836EF" modified="2014-02-19" version="1">MKINCNDSKLKRIYNFPEENILVNFRCNNIKKPNQKNKNFQLYDISNDYSNLYTSFNRNETKKNPFYISSLVEKKQSKKKLSNQTKKKKKNFEKKFPENIKINNIKRKNRHSKFRNPYVSRLCNFVETSNGKSDSNKLNESYIRCQLNNKINDSCESIIESVPIRLDKCSIFCGSTNIKENYKDSKLKGKRLISCIGNKEIEKDKGDEISKNHKHEDNIKKNNLNYKKLRDKSYSIIIKNKNIDENFKYLINTHITKEENKGTSNSKKERDNIVLRGNVYKIANNHRFKENIKNENESYEIIRKNNNKIKKRKEKYPIVNSTKSYIRDGNKISINNERDNEESYSSFSSACSDENSSYEVSIFGELDINYDFDSNKSDKLMHENSENMASKNYRNCKDNTNCSTTKKRDIELGIVKENKIKEKCKKCENSITEQIITNDTLSNAHKTNNLNHVHNNNNYTDLAKLKYDEIKKKDFIKNSKKYDLKKCESAQWENCSRINRNNRRSRCSRCIERKRDRNCNELFEMNFKKGYKQQKEMNCVEEEWERRKKMELNSKRKQILEKNKDKMDKYQTIYGVPKDKKIENINENKNIESYKKVNDIKTDKMRRNSDIRISKEIRNREGISISSNTIPNKNKIISRKKSYDNENFDEKKKDKFYEIYFGCKKLDKINYKKGIENENKNIYNIKIINDNNKYLREKEKDILLKDIDIQETEIEEDIHSNTCSSDMITPNNQNGNGKKKCSSKYDMYYEQNCSYCSGEKDKNKLSISHIKNDPNNNWYNRKNGTIRHLNEYDKGMKKKKKIGIFQSDSEHIKIEDKTKLPINLLNYQNEKKKKCKTFSHPPPKVINSIGENMSENKIKEEIKRKNWKDNRNTQNLSNIKSSNLYEIILKKRKQENKNCIIDSRINSFPSTYCYIEERGRNSSAHVCKSYETEENNYYSDTNIVNKKSNNFSTINNSFKAKEDEKSKNRIKSNKKGIKNENKRINQNLNQNKTWYKIPIEEKMFLSKSTQNSGGEIYSLNCQNSGGEIYSLNCQNSVFAFPHEYLDDGEKLKSLKKSRSICSGICVEKNKYNENEILRSSSNNSIIYIKKERNHKNDVGFKVRRDSINNKMKEKRNELDFYKFGENKNCRHISNCFLSGCSPKWKKKINSENDYHYNYILKDSNEIRHKNNNNNIWNKYNFDSKVPNEMEKINNIKIKCLSKNGKYKNGFCKNCFFSPCKNSVKKNNRTKSLFSKLFSYIKKNSLCNERKYKDSMKRNKSEALSFCKTNKNIKPPHYIYNNRSRSSGYFIDVYPIKNGIKNNSHICCTRKFMVNTKPDPINVSSDIKYIIDMSDNFEKGKLDNKVICNKIIENEIKKSALNLKGKNNYYNTKMVNNLRRGIKCDNVFPKNEIVNDGYMKRILPKGGEKRKDEKNIRNVKGIVKKGVIKSNCKYFLKINNNNGINNSGVNNSGVIKPLPCDDISTNCKTRVLKNINEEMNKTILENENDLPKIEKPNFLRLNLFDEKYEVAKQNKIRMNGNNDFVKNRGAKRPSKYVSKLTKLQMIKEEGNIFRKNLNNINSEHSNLDRNRHTKGPVNQIAKEIDNDIFIDTNDSYIINNQKMGDIETVFNTPVKSNNNNNGNNNGNNSGNNNGNNSGNRKIGNSLKYGENNYRKGNAFDVNAELNNPSKGYKIFVVRKGDNNKNPIENRILSNSMIENELALTNNENRRGTKHVENNEHTFCNCKNDYNCTCENIDYKNNTAFNNKGKKTIDNYSSCSNENIYLWENNNIKKNEMENYGDEIISYPKEKGSNIEEIENDIKMNKPIKECLNKPLNYLNKKLNSSAENIIKKIILNYKNVNLKNMNNDKLNNHKTKVSMDKCKNNKNFQINKKNIQKNIKDKLYLKVNKNVNNEKTDNFVNDMPKIRHTPNTDGNFILKNNNVNSQRNIDIKASNNKADIENYKYEQFRKKNYNSINNASYLYNDCIYPDPKIYFLNNDESCIIIEYPNIKYYIVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNS7</accession>
    <name>V7PNS7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase Rpb5 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNS7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="144" mass="16915" checksum="9A97AE7B73746798" modified="2014-02-19" version="1">MEDPVTRFYKCRKTCCEMLEDRGYIITAREKLENFAAFKELFEENEKLRSRMTIITSHKNDANNKIIVYFVDEVKKTGVKPLRELTEKMDEKSIQRAILVTQNTLTPFAKDAIKEAAPRHIIENFLDTELLVNKINNNKIIYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNT9</accession>
    <name>V7PNT9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SAM dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_01206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNT9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB61276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="83255" checksum="7D33558461B18F7E" modified="2014-02-19" version="1">MYSIRYNKLFIYNKFKANALNFNIIKRQISDICETKIIPINKSKEYDKFKIYRNNIYNDIYENQIIQGVKVHNLDPHGYGEIALYVTKHYFLLFLKFFLLIPDEQVNLKVLDINKKKKKITFQVLCKNKKSKYEIIPECEHFSKCGGCMYQHINYDFERKLKKNLLISLCIKYKIDILISDKNYLQNDHHFVKENEKINEDFVTISEIKQEYMSNDLDNEQGEENSLSNKSPIAKNDNDSYIYYNSNTGDSDMCENNNNQININHGHTKIYDIIHSDCYHYRNKSTFHFSVTDKLSIGFYKRHSYEICDINECYIQDKQIQKIYEDIKNEIIDNFKKNNIYIVNKINNNGYLKSVDIKYSVCNSENQILINFIGCTLTNEAKKNMINIANNLAIKNKSIKGILYNVETNKLKQIKKEITLFGQNYIYHTYNNYTYKLGANTFFQPNQYLNECIIQIVFKLIQNYKINSQTQCVFDLFCGIGFYSLPLSSIFNHVISVDYSIENIKNLEENIKLNNIQNIKPIHINLFNPNDLKQINLHIRRYIVNIIKNKNHPLYNNIKTKIDAQYVSIDSENEFMENIQKSNSPYTSLPNFVYQTLIEWKSKELNKNTANDIGKNFYKNLSNVTSQNLKDINPDTLSSNEISNGNISSNDFVISIPDLIIINPPRKGCEKLFRRWLRGLCPRFIIYISCNVNSQLRDINHLISLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNV4</accession>
    <name>V7PNV4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="841"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="949"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1401" mass="166519" checksum="6CF552FFBC5F59C1" modified="2014-02-19" version="1">MDPRQNNDIFNCIIYFVKNNNINDDLISVKNIYNHIKKNNITPNIVNPLDEDRNIFYSLFSIIYNKIKIYINLLRNKKYNNDFPNFLSKNYMNSTYISNNYIKTYDILYSPKCYVAIEYFIKTLSLCVSKLNIKDENIFFFSGINIISSLLDLQMAEKGNTPTKVGKNGKNCEMLNNEEFHLIVIKYVKNVFKYIYPRNAFEGISPANITTQSNTTNTANTTNTANTTNTANTTNTANTTNPANAASCKGEKKGCELDRKLNIFFCLLNIIRNLVELIINKNNKIKLKSLKLLYVIYKKIKNKYIIKKIFKCVSLNLFILYKSINMNKIKIIILKIFKKSIDKMLKYYISINNDIIFQYLKKTSYISYNTYEHFQQNDFIKTNNLIVKQCILSKINLEQDNKNLGKKYISLNDQSIIPQKKSTYLLNSIEYIEDKNIISNIYFICYYILFNINYNEYKKDTDFGDDICEIYNFCKVIIKYYKILNRNILLITFVFILSQFFYDKDINFLSNINFLFSDNILQYFEDNKLEIQIVEKLTQILKINFDKSNKNINLNQYMIANESDEHASYKNRERKKRFKNVSNSNRTISIDIKKEGPLSTKLGSNFANELHTIFLSFIKIMSEKKDKNQNYNEINNFILDQLNYNIENDFFKYLYNIFLLKKKNNIFIFNFLTGYIYYTFINHNLKIKNIINFSTHTNSYLIFNFLLNLYEMDEMDELSDLSPTHNKPLKTNIYNIILNENNSFYSIDIFNNSPLSLFDNIQNLSNSFYFVNLLTLTNVKSCFKSQPTSLVNKISMFFFLGIESSQLERCINHILSSEFELKNEEDNKSNEDKKMKEKCKIFHFLNHFLDFIIILLWIKTNITNSDGKYVYNIYDKADIYNKKLETELVKNILVEYLDIFNNFFSLGVIIKLSKFKLNIQKIVENIICLCCKKIKKNKIWQDNKNSTHYYFISLLIICINKSFLILHLTNLYDIIKKYFYENLVLFLLNINSDSNIIKQLSAYFLFATHGYLSSNGKWSHKIEESGSEKRNGWHGERQNGWHGELAHIIDQYQDIITSYIYQKLISIESINKCVKIFKLIKILISYNYSNIYIYKDICINIIKITKKKINGFLFLKNRNKNNIVLNIINIFNYILYLFYKIIYKNRIKILSQKKYMYAIKDQIINGHVYINMNNLKNEIKKKNNINNLTEIDVDNNLFDLDHKIDIPHQFLVEKNKKIIFLYNLFFFKYITKFTKENKNTFLNNVKNFYKNIKKHIYTNINYQQVPNLIVDDYYDIVNQTNNTNLEKKNKIKNYQNNNLNNTEYTDQNTYSIIISTTSHIFYFAKKYFSHDDDYIRYNAQMCILQCLFIFSTHRLELYPKINQILEHINADLSQDRRISNLIILTMLNYITIVDDIFPTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNV7</accession>
    <name>V7PNV7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNV7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1212" mass="145038" checksum="A800F22ACCC5B455" modified="2014-02-19" version="1">MFLLQNYFKLIYSIKSLSIYKIGIFSILFNSLFLNKYNQYFSISNDLFGMLFTNYFFYEGINNLTKKKIENFMDKYNCTKEDIFNSLNDLFSQFLNKQIYIEKEMDEKIIYNISSFIKLYKKLFINNIDNIKNITFLVLNKYNVYYTSVENINKTNSEILSRICYIFYIINILLKYNISSLQNFNLINNNEYNIPMFKSNNKLSNYFLLTSIKDHLMINENVINDCILDRMKKNYEKHIYSLIENKNLSTNIFDDIKKLEFLILDKSLINEVNLSIFNKLVNGILEKKNYDTPYFKHNQLASKENGDFSNVKSNIIEDTSSTGQLMGNNEINGDEQYLNNNVIKDDQNSKDDDDDIEKYYSENTNYEEEETEDIEGTDAEIYDDNENIDERMYKYIEDSVDYIVEGNVKKDEQNQETKSSNGKDNNNKSDEGEKKELETMLKKIKDIHSFRKYLSIPKEFVDNQLEKYLFPYMNKEYKIFLNNLIFKNFKNKNENLFFLKNGITLSSECTENIIKNIILDFVIKTKENINIFFKLDNMDKCLKLVLNLFYVYKKLKKKRKYIKTKNMILNLENIFSHNSFKGQTFGKQTISSETTKETTVTDYTDDTSILNKINDTKKNNVNENIEKEDYIDSDISFPNKKEEFLCNENFERNMREEEEGEEILSIDERKRLYEIFVLKYMKNKSERNIFKKVFKLDNVEIDKEVEDNIIKNFLEKVVKSNLENLKKLNSDLGIINNENLFDYKNLNFIDKLEKVKKNNKHDSNVNINKYIIKKDDIFEYIDDESFEEISKKMYINKLLLLKDNLYNNRKDLYLYEIILNINNSEGIHDIYLIDQYEKMINDIIKTNLLNKNYTNIKNMYLKKIINFLNISEQKATDVELRCIYDHIYSIFLSIKENFYIYKTDSDFFNNINEILTIYNNYDLIKKNGEGYLLKFALIETNHNLLQKLIERYVLYVIDIINNENKLTYKENIFKLAKILNVNNTIISDIGAKIYKKYIENQELHAMNNMDVFFNFLFNMDKGKQGEIILDYLRQKVQNHLNSNESYQEKLQKLYDLLNFINNNLKLNKNMFDFYHQNGEIIYEFLISCIEDYLDRKKSTTFISSQSDYMMHFNNFLSKIKMLIKGPEEKSHFTHVLNILKKSIIKKAISFMENFKYDLCVEKLYNFIKLQMIDNTFVLSDIDIEQRKKMINIFSYQNIDDEKKHLYMDILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNV8</accession>
    <name>V7PNV8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-seryl-tRNA(Sec) kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNV8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052648">
        <property type="entry name" value="Ser-tRNA(Sec)_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873:SF0">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="69710" checksum="94C1B5FBAD3CD8D8" modified="2014-02-19" version="1">MNFILLFYGPPCSGKDTLIRFLIKKKKKILFFIYLLYNLKEPYISYKYSYEQKFFIQLIKYCNKINKHFKLNNKYRIRKINHLSFFSLINLYKTFFITLSDSTFHSNFQTSLNTIYAKLKKVKKKKKINISSHTHSNSNNHSHKNDKINVTNVCIKISRKKIINNVTKPKTFFIFYKKFIKQIKYFRHFLSKCKTSIHNISTDSIEKQFYSTQNEKKSEKKYEKKYEKKSEKKCEKKNIAVVTDKIIIFEKQNYKTKIYYPIIKKRCLKNKLFFLSKAKENKNIKPTLFNQKKYWKIARKIAYLYCSHLINAKKNAKTDTKKKTKIGTKKKTKKGASTSTQNGPRLKHDQNKIIILNDTFHFPSMRKKYYLLSKKYNSLYIQTFLNTPVKLCIQLNINRNKFKYISKETIIKNYLYHRKYAVALKNVPKNEPKNEPKNEPKNEQKIINFVKATRKWQANAISIQVNRLENKNKLTDLLFFIYKYFPIFIKEINKKKTVTKKENHNPVIQTNALEIINKTANKIIHEKLKSVPNGKCITTQINNNNNISSICSCSSSDNNTLTCSTFFRSKKCVCPKIPSYKIAALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNW3</accession>
    <name>V7PNW3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNW3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000242">
        <property type="entry name" value="Mitochondrial ribosomal protein S17,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB61084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13837" checksum="742EEA2ECB09F2B6" modified="2014-02-19" version="1">MIKLSATSLYWHYKAWQRATAGYLRTFVKNNLANNEMIGYVINDKHPKSIRVACDRYMYVVRYKKTFRYTKKIWVHDEKSEAKIGDVVRIQPLGYRIGPWKNYILVKILYKENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNX3</accession>
    <name>V7PNX3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_02759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="3127"/>
            <end position="3302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1420"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1508"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2683"/>
            <end position="2710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2766"/>
            <end position="2893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2932"/>
            <end position="2959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3080"/>
            <end position="3117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1533"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="2683"/>
            <end position="2693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2694"/>
            <end position="2704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2766"/>
            <end position="2778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2779"/>
            <end position="2791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2805"/>
            <end position="2814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2826"/>
            <end position="2845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2864"/>
            <end position="2881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3080"/>
            <end position="3103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB60477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="3302" mass="389287" checksum="4B13515BC6E09274" modified="2014-02-19" version="1">MKKYMIFENSQYSYIINTIKHGNESEKLAALNDFYEQLNLSVDGGISNSHLEEYINVLIHVINKPHATYDDSYKNSGNKKTSKGWGNDKKSNNDKINDVVGNGLNNFFKIIQEHIGVYATSFDDMDDFDYSDNNNEKVRGKKKNNKGKGDDENNNSDNNKKGNKKLLENLNMNKEEKIDKANKKEEKGKDKISEEEEEEDDDDDDEENDEEESNEHNKNKYSSEFDSEFESSNNCSSITSECSNEFDNEKMFMDEACAIDVKYINMIYTATCCIYTILDIYPNSIKYVINNRDCVNILNKKLNDIEYIDVAEVILKIFEKLVEKDPMLILKKKSIKYMLMHIDFYNVNIQKKIFFCIIQMINNIKKYKHIKKYIMPYCNTYVNFFHFNYIHILNIICTLWRSLLDKIITIQLDNDNKIRRRANLLLLGEDRISNSRKSKNKSTNEVSSYLSKLMEKKKKKKKKKKKKKQGCNDSNDNEDKTTMKNMHTKEENDKSYNVIEISDDENKSIDISSDISSNSKSKKKKNSQKKIASSISKNKKSKCSENDMDDDHGCDKKKKKKKNIFNKKEKIDKESAKEDNVNDIDSNSSCCQNKNEKRKKTKKKKEKEDVYNLDENDQGINKNEQDNKKEQDNKKLFPTLLKNVNESTNVANESHVEVKGEEKNKTNYINNQNNLLQNIIHLNNNENINNKLCAEIESVYNTNIRDNIVKLLIECKIEDNLYAFIETFYIISILVNYSNNILKDFCNSDFLEKFNELFDNKKFKNNNILIIYILFTLYSFLPICKIDGSLIHKYETEHLLGKKNKEESLKVSIQENDIFSNGEFCSTKCASLNFPVDVKKEKLDFYKNNLKYLMTVIKIIIPNIYTIFEETLHYDTKYLCTSILLSLFISLYKISFTSFNDPEFVQCLNYIFSYNTELYSFIRFCILNNLSDTSVISGIIICKIVESFVNLISTNLIYKELKEKLNIKNETTTDESYINFTMNNKIYKNINIQESDITNFTFNDNKIVFLHVLINIIKNILLKKKKEIGTQNSNILCNSNKQIYNIIFLYFYDLYNSDCSGKNIINNNSYLIPHKILCNNLEQNDVDTTTKNGKLLFFNYERESKNVNLEFGTIFLCYENVKKCKNNDGSNIFLKDLIIDEISCYNNVVLSYYYLINLFCNLYYMREDGSIYFYKYNIAKRLYFFLFQKLFYGNTRKKYTQNVDNWQERNGKYVLKNNTIISNEEFIYKEKQKKKILKLLKNIDRNLRLYIFLYALLFINNEKKEDIVHGLFLNSIKKLYNILGIVKNIEEMNKSEFNNLKSSVLKIFDVYHYNLITNNVSFYHFSNLIKLTKDCLNMFDNLPMHFFQENLNSANNCLHTNINELYTNINNNNNSNNNNKAIWSSNSDDFPSLHHDNYCGNNMLGSKNRKVSDNNLSKGLKQKKKNNKEDPNFDEAVDNSEANKQIEDDELGTNINEKKLDTSIFIEEIDEEKKKQKKTEENEPSTFYNLKESNKEIKINRKDEIEKDVSSTNARHNSFPIKDKKKSKGNNFIDEKDMNNVKNDDNNNNVYSYLNKKNYNNVYYVSKGSFYDALAKNNNINSNNINTKYNDKKGKCMYNNYNCHFPIHLRRNGLYVDNVAIFNSLNKGIQLSMVHDNTDEFSNNRIYEDFSKNVNNVAYDCTKVEGEEENNSCNLSYKNKEKDDKNNKSVNLSQKNSKDLKINKMTYSKDITNRFLYFSKNDFDKSKNLQGSFNIFESFNKVENYIRKNVNKNNKNYNSKYYGKNDDFIVLSINGINVHKDSCISEYLVKLSDLYYLNKNESYINEENIYCNFENFYVYNDVVEHCITNYNYIKNNIKYLWNNNNNQGIYSTISIANNKNNNNMHIINYKIIKKRKHSEQTYEQALFDDYDDDELMNINNDLNIITKKKSKKKRDNNYDNIDENIQKSEHNTFYKNDIYSYVSPSTYKKIKSSINTPFSCKIINQKYNYYNISFDLVKHLHTNVDEHIDTSHTKLSDIDVKTSGDTENVMVNNFFTILKTKAQKEGCEKNKNLYHEMGTIKDAYDSRSLKHVSGKEYYNELGSEKIENEKKTSSFLLDHLKNCYINNQMDFDLLENNYVENDSIYLSTYLKNEMTKVIELILLDNHYINKDIMLSTHYHNFNVVLNNEKNKNDNKRSTIENIEMGRMWENNLYKKYYEKKKKKENKEKHQDPLLQYENMTKPAFEEEDEFYMLFNYMPMYSEIIKKGIMMKRENDTEWEYDQRCFNSNNVKNCLCNNKKEKKMDRDIFIENMYNFLLYKILFLLFKHFKISNTQPLFNFYMNNEVEDKLILDENKIESMKLLNDITKDEMNFVKCVYLCKNNKEKNFEEPNKLLLEINEIEKKEFILNSLNNKIMYYLNNPLFMFSEKLPSWIYKIFYLFNFVINIDIRSFFFEIAYFGNYRGLYNYKQRIKELVDKFNEKVTTKNGALMEEHLLSVCANYTYNSEKKKIFNFLQDNTTLSLPRTKIKLHRNKIIDSSFRIFNHIHYINSNYITPSYLDIEFFNEEGTGLGPSLEFYNEVIEELKKEKLKLFKIENNYLFPISYKIDLNNFDFNLLKKPKHSELTNMTNNSATDLGAAFSGNLHNFNNHRSFVSNNHNTYNSSSINKRINDISDGLNTNSYHSVNSFINHFLYSMNSNIFNKNNRNLDIYDDISKIGILDKKSKNKKNKKSGKKSGSSKVKNSSITDINNDNVESDIKKKVKKKKKKNDAQEEDEIDDVDDVEEIMGDEQIKNCLKKINKKEKINQESINEKPKDKKGTTNQDSCIDNYSENDINDVDDNINSEHINKPIDISDKTSSYKKNNGFDIKDENAKIYEEKHINTEINKKKRVRSYDGENEEDEDENNKSVDEEDNISVKEKMNDQSFGEEEDEYGYEIDEYDDEDYYDEYSEYEKGEKIKFSFEGKKNNLKKKKKEKNLNNKGIKNSQTNEIAENNEKMKKSKNDELVLEKKIKEEIKNEYIIDDNKRKQTEKGEKESKNSNIKKYKLFTKDFEEHFLKEDNVEIGKKNESSTKKNSDSNKGFNLVKSETQDIINLLFSEMNNKTPLDMEYNISVNKNTNISEKENERKKEEIESTPKKTNETINKKGNSKSRKGTSTDQDTLENRLFKYFKLLGQLCAKILTDNRNVDINLHPLFWYLVMNNSGYVNMSKLHHYQSVDAVNMNSINKLLEYRKSGKNVEDLHLDFTLLGTTPPIKLIPNGSDISVTNENLDLFINKTIQYSLYEGIKFQVWAFRFGFSTIAPLICTNIFDEEEICEYLFGNSINNDEYWTKAHLSTYIKPDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNX5</accession>
    <name>V7PNX5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNX5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="161" mass="18494" checksum="E1C4F431DB80A6C4" modified="2014-02-19" version="1">MASKPSLNLKDNQWEVCNYKNEKKIKLEKVELNNSVNIYNCENTNFTIENPKFKSLQIQKCGKCNIVLNNLISSIEIIDCKKIKIQVLGKCSSISIDKCIGVEIYLSKENTESEFTTALSSEMNVHFEKNGEWKELTIPEQYQHTLCGGKLNTRVSDLYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNY1</accession>
    <name>V7PNY1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1717"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="829"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2223"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2424"/>
            <end position="2451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2478"/>
            <end position="2514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2243"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2283"/>
            <end position="2296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB61104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2742" mass="325052" checksum="1D5AF7F85EF96B36" modified="2014-02-19" version="1">MKRYNIKRLLGIIMCRVKLYDEIHKFENSVMDIIIHREDYKNCLFNENIISKLIHEIKNIHKELYQHSCNPESKNSCYDIFYENEIFISEENEQNYNYYYTYKLHNYVLSYLEKSQFFNMFLYILKEFEKHIKNILFLNSYDISFITTLNDFIFYFLNCSGGINLLINYNIELYKKTYINICLIINKKMKQLNSNINNKNEEGEGADENDENGQNCQTGQNGQNGQNGQNGQNSQNCQNDNNENNYSQNDDTEKEREENEFNNNYDFDDPYNENNHNGMNENNQNGMNENINQIKNSGDSECIFPENNNLGFIQNKKDEDLNKEGFNNLDEKKEKKILYNEKNFFYDNLKCVYTYNDILRNKDISDIYYLNGYNYKDMKNTRNSCSYILCSIIAFYKSNLLINNFFKSEENISLEYLKIFSSLSAYPLFKLAMCNNRNILNLLTHLTHLLYYSIFLEKQYEENNSSNSQIIKFRKNKINDNNITEGDNNNSTNFFEDNNMNKSENNLISKNVKNKFYKKNSNEYILVTIKYILSIIYNLIFYDYSGYFIFHSGYSIFVCLEEIKNLIGEIKKKKDYYFGALNSKNINKFFLKDYISNDKILFKKYFIMYENLKGLYTDLYKYEKKKFSEMDIQKRKDTYRNAMLEFVQKCDKSNGEHAENGAYLNYSFIDKILSIYQENQFFNFLPLRSCYTPNVCKIIEALRIEKDKYILKKSKELNNYNCKLNNDIYISNSSKSCTKLGTTINDQYVELLEEFDDNIVSTICSNTTISELNTIYNTSSVIPNIETNSNSSLKIGYYPILPLNLLYYYMNKCPNISYFSDLYKTNHKNEHDENEHDGSEHDGSEHNEGIDKEDNKCDEENGSKFYQNKYGLFVYDNLIYNNYICIKNKKLDEKNKPIMIQTNNQFFNENDKNNDNYINKYDENNYKNIGSKIYLTNNLEFIIKLINKSIFFLNINNLKLALIHFNKLNGRNLFKIIKKRLKTLNFVKSILNVLFNFFYNLTAISKYQKIAMLKSYRNHELFYSLLYLLNKLLSFNDWLGSNNISEYNHHTSIYTLRYNIIYILRIFYLWYHNTLDNQSFLLRSVLRYTRILPCFNISGMLLLLIFFDFKNIFPEYIYSFYLSTNLKNICYENCASTTQHDDSQIDKQESDKTEISDSSFESETDSQYFQTFSNDNSESDGNLSTVMSQESGRKGGKNEDAHDDESNSSIDEVNKIKLDLVNNCGNLEHVKNINKENTQEFFNFSKMVNNNYTGIYSDVEADNEKSDSENENYNDEIKKKKFEEIILYSKIEDPYMISNISGNNIIENDRNINSNENRNNLDNINTEKKKKLIYMCCSINTTKRIINDQFLKKYRILNLNFGENEYENTFYFTNYHNRLTNNYLSFIGNLNINLTDLTDVDNKHNINIVNKEIEHSIVPPPPNTININKNIYNSLDNMMHKNYIGNNKSGISFLSHNKIDIKKKEKNKFENDNDIISNVKEKTTIQTTPYPIQNLLKDNEIDNVENIMNMLRNDEHIFEEHINIKYLKKDEKEKIFLIKKELKNREYINFEDICDYINFILRIGKSNNVISRCLSAYCCVIFINHRIPIFSILFKHIEDVISNLISITLCDKKDENNHNNTTILMNKISYFSFYSYNNTQSNNIYYTYNQELYILKELCNLLCFVLDILKICFFNNYKNSYNKLIKLLYLPSNKLLNIIQNLIIKLNNIFPQELIRFIVKIISTIFQGYIYVFFLYFTKNTIIHGHRNFPNTSMQCSRPMQCSRPMQCSRFVQCSRFVQDDTNSLFINKDILISEKQNLFLLTKKDKQCDETDDNQSTKLDTNFSEKKNEKNSNIKMEEYTQVFFSCPNYLKYIRFFFKFYFNIVNTKNVINDNNKDIIYKYSDYVNLKTVTMCLSTIYEIIKNKIIYFFIFFNVEKRLENIFFKYIKTSQNKNKNKNNIVSLFTNADNGFEKDPELYDKENYYIHYFNFFLKLNKHINISNLVEFLSFYFDIVQDNTNKNLYKIIELYEYLNIIEIILNIVIQIINYHFNSIFILIHLFQNNDQEAIKLLDHINKMYKICKIQNDTKQIYNKIDINKCRKKYFKSLSNFAKYIFYFKKHFLNSLLNSLRNLYQFVLTKSNPTNHNATTNSEPISNIEPDLLNSSNFTENIIDKDKNNSLIILANSILMIINKLQNVKRKVLNLDTSYIPSITLKNFFLFICYDLDQLHTLYKHQSLKRKTEFELDQNQNHQSVPLPKRRKLGLGEKNGEKNDENGEKNEKNEKNGEHGEHDEHDEHDEHDEHDEHDGHDEHGETRGAKRSYSFYFENMYNKTSFVINKDYLFNKLGEVFYSNYLINKIRKAYESHQHLDNNYLNTIKNINISNINPAVNKKIYDYPSHLFSDILSKIYLYENDEDKKSFILFNLPQENKSKEIDQTHSLYNYINVLKEELNKIEKKKNELLSQAKNKQYNKKNDKNIYDDHFRNRKTISSRAPSKHVDDYEAEKGNANQTINNENENDENKQITEQTELLSNNEISSEYIGTQNKNTGDLNLGKNDNTFTNYTNKTNANNANANNANNVNNVNSVNSVNNVNVNIFKNTNISSGIDMEGNVINNFNDDDNNLGKNQKKIQKKNINYLTKNNINNDDENIVINEIDQNYQHSNCNNNIDTTNTESNNKNISPDTNELINKSSQFEDCTCYKFTLLGWKEFSEDGHKHDLDVCKIVNKPVLLKDPRIKMKFLRILDRHNNIKDIFKKLGVDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPY0</accession>
    <name>V7PPY0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Protein transport protein Sec24A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">YYC_01980</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPY0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000012">
        <property type="entry name" value="Protein transport protein Sec24A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="14">
        <location>
            <begin position="237"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="15">
        <location>
            <begin position="311"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="17">
        <location>
            <begin position="585"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="16">
        <location>
            <begin position="681"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="13">
        <location>
            <begin position="798"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETB61035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="897" mass="100872" checksum="C535E8AD1DF8BF25" modified="2014-02-19" version="1">MQPHDSNRGLNNFNNSSNTNSSNNALNYSNQNNMNMPIASPFSYSGNTTNNINRGAGNVPPMGNNNDNAGYNTVKGNPNYYSGQSYYNSQNPVQHGAYAANSNNLNEGMYGREPPNSNPYLNNQGQYMGAQNAYMPMSANIPNNNASAFNDVGNNLRYDANKPINSVQPIVNDTYQEFLQFNAFSHFVKSSVNYMPANATLKQKTHVPLGFTIQPLAPIPDGYPELASVNFGNSTVVRCKKCRTYINPFARFEAGGKKWNCNMCYNINETPQFYFVPLDEKGKRKDLFQRPELCTGSVEFIAPSDYMIRPPQPPVYLFLIDVTVTSINSGLLDVVCNTIKKLLPKNNDDNATNANSNNKKVFDSRTLIGIITFDSTIHFYNLNSNLKQTQMMVVSDIQDIFIPLPENILVNVHECQNVIDNLLDNLPNMWRNNKMSDCCAGNALKAAVMLIKKVGGKILFFLSSVPNIGDLTVSVNREAKDKGSSYKKIYNSGSSNNSNSDLKLREVEMLNPANNEYGEFAQSITQFQIAVDLFACPLYNIDLASIYPLIKNSGGSLYYYPQFNVHQYSDKLREELLFALTTETAWESVMRIRISRGWKITNWYGNFQFRGVDLLALPNCHSSQTFSIVVDLEENVVQDSVVYVQSALLYTNSNGERRIRLHTYALPITQNIKTITDSINPQVVVSLLSHQAIEVIKKGKIADGRNLIQTLCSQVLSTQLSSSENSRLLPIYILGMLKSVAFRDSGDVPPDMRIYQWSRVENIPIESIEAYFYPRMFSLHNLEKHHGNYDENNNFIFPATLNLTCENMTQDGCYLVEDGENMVMWIGRSINPQWIYSVFGVQSLDQLNSEYAENHIGSSDNPSGLQVLNIINALRKARTPSYMKLMVVKQGDPLEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPZ9</accession>
    <name>V7PPZ9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_01509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPZ9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB61661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="46191" checksum="00B845A06E1D56DC" modified="2014-02-19" version="1">MKTILKYAKKKNSDQNEITNEDDQTTINCISINDININDIEENVITRDNNNENKKKKDKKIEYYLFDVESYNSNNDTSLNSVIDLNSIKSHYLPENKKKNAKKKASNYIKKHVKKYKKKYKILPEHNLDQDTSYEESVKNEKKDYDTYELKEIKNDKTNIDFVPSQKKENLSKKNNSFIDVIKFVFLISCIFSLGSFSTTITKYIFFVKKFNYTQIVSFFEFLVMFLILKTFIFFAKIKSSTSLTRKQYIRYIVFISALLGLSAISGNSAYSYLEIPVISVIKSSSLVLIYFLSIKFGLKEFKCSLLVSILTILMGVIMSITTLKIDSLFGVFLLIIYVISSSFKWVFTDILLKSTSMKAHIILLHIYQISMLIIIIPTLLIDMPCIINGKEIIRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQ77</accession>
    <name>V7PQ77_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQ77"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="617"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="760" mass="90074" checksum="FD056E647C713494" modified="2014-02-19" version="1">MKDDENNSDINNSSIGSNYNDDYSDLEDLPEYERELILAKRHEEYMKKKHRKILLKKINVDNKIEKNESDNKKTTQKKSKKKSTEECTKYNINNTPIESNKTKSAVIVKRIKNDKEETDYSDNYENSEIKRKTKKKQTSSLVSNKDQGKKKLRNLEKEEKKKDPKNKHKNYTSSSYESSSIYSDKSYRKKKSRKDNNIPIISENSKKRLIRNKNYNSSSQDENQNDKYIGDEKVKSKLGKNYTISENKIKNDDKYDDDDNKIINDKEEELLNKKKKKGWDTSEEITTLLNKKRDDRSHEYISSGKSIQIKNNTKYSNDQDKTIFNDLKKKKKNENFEKSQSPVKDTETPERLIQLYKEEKKIKLDIYKYMTYEIINYFQLKKTFLLDMSEHINFPYYVIGHVVKIDDLPKLIKTSDYAKNKNYSNNNITGIEKNKNIFFLKNVIKCDSYFCIDRYTNIKFEISHLDNLKNINFFKKIKKLMNKNKKIGINELDNIKNNNIDTTYICDINNISDEKLTTDEYNHLKLYSINTEILKKFNIFLKEKIEDLKNFHYTEKQIQDLVEMKKKKSFYEIFQNNKTIDALPISRIVVQREICSILREIDTLNYSKKKINDVYMISKINKQIDELTKKKDILREQLEKTRSTLTSMKTQDSISYETGKTISPKKFAKSYYNSGLTDDNFKNIIGDEKKNIADMANHINDEKKNFNSYITNKIFDLPMDSHNKIMHHFLHGSLQSSEELFNDNLKIHDDEYDLFGGNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQ87</accession>
    <name>V7PQ87_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQ87"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1150" mass="124932" checksum="D95602148FF5BF5B" modified="2014-02-19" version="1">MPKDMCMIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSGPTDGQGGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQ91</accession>
    <name>V7PQ91_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQ91"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="842"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1137" mass="123613" checksum="FD70794005F824AB" modified="2014-02-19" version="1">MIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQ94</accession>
    <name>V7PQ94_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">YYC_01590</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="736"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="771"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="800"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="746"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="15">
        <location>
            <begin position="1581"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1465"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETB61771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1922" mass="226454" checksum="B5401A89D5C5A240" modified="2014-02-19" version="1">MFENKTKKRSVQNKHKYIDGDKLSKDKDKLDENGSNTEKYNKIDEASKKEIIISSRNSELIDNKKIKEINENGYNKSKINSHDEFNITKKKMKNNNDNIMYNSPNSKIKVVSNNNFKDRKKGIHHKKRRSIYINQITLFKIHNYIYKTFVFLLCLFIVILVLYASIDISQNYGPIIILYIIMLEFGSMLISYILLQFPFFYLILKNMFTRTSNINKYSHQYSPLYYENPSDSDDKDSIDVKRRETKKRRKTFGLFNLYNIDNNKYSIKKKILSTKLKIYNKEESDKNEHGNLNHALNTNLSNAKSRSADEAENYIIEDPNMNHNDQNVDNNSKKDNQSIKIRNHKRENIYLDDCNMWIRNSIKKSRTKGNFNLTRSLSFNIKLSESNKVILNDSRNIDNLRIYLNHRSSKYEKKKNQINSLKLFAHNKYAPLTFSTPYKYSVPSDIFKTNTEGSKNLSAEISESSDDVNDLLHKNNNKSYSEEKDSSYKRKKDKEFYTDKSAILFSNKHTKQYVRKKTFMYDDLDNLNIYINKKHNQKNKKKKSIFCKIKGFNKIKNILYFFVNYNIKSSKTQNNVLLFFRGLTLYIKHQFIQHLSYEPVWIIAILIRIILWCIVWLWAAGYMTRPPKNYKINAWNMKSIPPLYGYIECTFQWCGVLDYLFGLYFSNNKLKYIFSFFSLIDFITTPVSSFIMNFVWKNDYHQTYWFLILGPLRFLRLVRAESTMSSCFFWLSDVKIIIIGIIILSLAILFTFSGIMYILEAPDIERQFISPLDFVYFGVITMSTVGYGDYTPVTPAGKCLTMFIIVTCFTFVGAQLKRLKEAMFSPKTIMGIIPKPDDDYILILGPVSPTQLLYICKGINNSFPNSVESIFLFTPLPVIIYRYVYGSIIKNTNIKICINGGNECFICPSIIYDAVINARALYILNNVDSEKYTLLNQQIFLASNNFNFNNNDKNQRIRPEDILHNNIINKFTGDKKKTWKFTDIYSEHKNQINKNNMLNLEMNINVNDSHMIREKDDQECILRFIGTYNISNALIPITVQLSNNTYEELIKSMNVYNYISIEELKYALLAKSINCKGLFFLIINFFYKPKAVKSLKKYIIDLRLLMYNNILKKKNHKKINSTNIKIKNFNELSSSHSENEVSDTSSMLNYKTKSRENYKIGKGIQNKFIKNQNYNINSIYYANNENIHNEQNNSVNDNALKINECENDDNLIYNGYRNTYGINNNIQHYKSNSSKSFYNNKNSDNYNEGNISFSKTVGSMNSSQDISSKNYYNILEKISLNMYYYLEGLKYNIYRFQFPECMRGFLFQTASEYLYQKHGAFLIGIITINKEIFLNPIDYIIGEENKYYYTSAFSGIILTTSLDNLIKLSSIKSISKKVSEYNQRRIDERKKRYAKNVVSTDGENGYNKDLELGEKTNKNYENIEKNKNIDKWQNSIISKQNTLTMHRENNKINKLDKSIEQNTNIYKINDKDNSDNNEDQNSKINKNNSNFEMEIISKKNKLILYNFVLGIYEVDNYVSAYRDIFDDKKKPLLLICGWPDNIHMLLKHLKINIYKTMKYKKKNRTIQNGNDKYNNYRSYGDRMKYNIIILSIHVPKFNYENDLLDFSNNTAFIRGSSMDSTNLIKGGIFYAKRIIILNSNHSLFVDKDAYRIDNEVIIIKNIIYQLYNNIFKNKKKYLEIIKKIFKNEYKDKHINEKIIFDTNNNKHDEFQDDSYTSNSDSEIKIVNKQKNKINYNIFNVNKNPYIICLIKNSESLEYIDGSINLSYENYNDNEKMNKIWENCGEYIYTFELVSANIFVDEMLHNLVSFSLPISKYAIEYSVIYSLIGININEYSKNVNMFHKNLKLSTGHVLIIPIPSYFYKKPFYRCFFYLLHKKKYLCIGILRYMNISPLRNISRKLFILSCPSRTMKLEHYDQVKDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRZ7</accession>
    <name>V7PRZ7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRZ7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB62199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="130" mass="15623" checksum="85D92AD340E959C0" modified="2014-02-19" version="1">MVNEINVFFFKEIRNLNIYENVKYSNIRILLSIILIIIGGYCCIFVNHKNEPILMIQFLAAFFSISIILYIWEYFYFEDYFMIIETNDNKAVKLFLKFDIKTSCLILNYKLNKTVYSTPFELMKLYNEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSA4</accession>
    <name>V7PSA4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSA4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1175" mass="141233" checksum="E86E8FF183FA316B" modified="2014-02-19" version="1">MLKEKLLKLLNYYYFLKNYYIYHILFVYTFFLRITYTYAEITISHFFTFLLNKYDNIDTNDNDGNLFYYFTHFFNFNNKSDDKFLNTKLFVVVYLPICLKCFYTLFFDYISYYIYMYYYFDKINDFKKVYYSSIPYELSKLHQNECIYVDRDKNGKGNRRESKKLKKNPITPKKKIRAYIISKRKKISQNDFLNKLNDIPFERYKIYLLKKKINDLLSGKRKSVLTIGRHNTNEMMNPLSGREYEKEQKRCMKIKIEKCDDKHIRGVLNGNSNTRGIVKKNVFYNLKKKKQKKYNNSNGEDLLKNSQFKKKHKISILEKVYMKMKKYYNGERTGGEYVSLTNEGDNDSINHSNNKNEYSDNSFAPKYKNYIYKENVHNYRGKNNFLNFRLDRKKKASKNNDCYIKLEDTEKNSDVKYNVNGELKIPDMYCSSLNSQCSSKNKSKNINNFETYRFENNNNKLVNPIKNEDIANRHHLNNDNYYKDDFMEKVNKDNNGKVKFDECERENDEKTNEKRRNSNKSLKGSLKIDYLFKDSNELTESYIKSNEDNNDYEYYYYYYYNKFKSFRYGSEDNNSSIREIINNKINEEYYHLKLNILILSCIIIQVFNSFILILISSNFIRKKEYIYIFCFLYSLLESVTDVISDNIFFLCGKFTNIYRTEFSLNTIYVIQVISKMILSISTIFIYFVYHIFFILYEHVNIMIINTFIKALSIFVLSFIFLKNKDKILKHSQNEYIINANFDEIKDELDNNDNKTKSVNSFSKKSSVSSKSTFEYGVLEGEKQNSYRTLRRNNEENIWPEDDETTKKKNEYNFDHVNKNNWESYYNNGIKNYTIPSFRNNIFEGGELNIDDLLTHTIYNENDEENMYVYSIFYKLKKIVIDNVNYIKSGCCKLKDIATRGQKIYHLNSKDDYTLLTIMPSKYEEEIYHKKYHMDYKTNNNKKTSIIENIKNAFKNKAFNCYPSFKNSFIEKYNSLIEKDMKIIEQEKKNIKNRNGNNILNKLYSDDTIQSENDNNFTYTKQNKSQIKHHKKKKIFTYPIKLLLNNLNFSNIFYICLLLIIPTFERIFLNYKIKNIHLDMRSYCYLNFAGYVTDLVGLYIYISYFNEDSYTSSIFISSIINISLLSLRFILFQNKFNQLWLLFLEIILKSLHKTFFYIPIYILVTKVIYLTPLVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSB3</accession>
    <name>V7PSB3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_01720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSB3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="83"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="178"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB61950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29609" checksum="4BDF0D666D7494AC" modified="2014-02-19" version="1">MEHLKNLITGALAGVVVDAILYPIDNIKTNIQAKNQLYSIFEAKKLYNGIIPTLIGTIPASAFFYCFYEMSKKYISENNPNISKSALYIASTSIAELTACIVRLPFEIIKQKMQVSSEASVKNIINGVLKMQGAQSFLLRSYLVIIIREIPFDCIQYFIWETLKEKGQKYFREFYEKHPVIMSSLSGGIAGATAGFLTTPIDVIKSKHIIYGRSYIETIKEISKGGYLSFYKGCLFRTCYLFFGGLIFFGALRLFSFKKDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSC3</accession>
    <name>V7PSC3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005548">
        <property type="term" value="F:phospholipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF11">
        <property type="entry name" value="VIBRATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="835"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="496"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1465" mass="173200" checksum="5AA3344BC128DA12" modified="2014-02-19" version="1">MKVVEFRICMPLKVEEYQKCQLYLVTKGTLEDAEQRIKNAEKYGSENNSVGVVILKNESYVENYTSGQYTLKKLNILHKMPKWLLNFVDKKYCTIEEQCWNAYPYIKTIYQSSGFPKGKIQLESSHHSGFDTEYNALNLSEDLLNIRKIIYIDIVNDKVSSKEYNINEDPSLFLSQKTGRGHFKQNWKETSEHLMTCYKLITLDIPYFGLFCSKIENWIISAIRDNLLKYHRKAFCWIDEWFELKIEDIRKIEKDVQTKLKKFWTETGQDVPTDDIANHVTSSEKGGKSEEGESEKSEESDESEKSEEGEKSEKSEEGEKSEQNEERNRSSSLEESLTNEDESKCESWSNISDNENIKNGVNKTDKYSSNINERDIFDEASKNSMAFSSAASLNYKNETTENMKSRNNNIQNQNMHMNMNNLKTCYENRVCDLEGYEVIQGESEIENNELDENKNMNKENFDFFDEGKSNISVNKILVDNKKKEIIEYFFFKKNKNEYGEYLYKISDGMFYSWKYRYFSIKDNKLYYYINDEKNDLKGEINLLNAQIHWIGEYKGRNNVFVIQCFYKNVYYLSIDDEIQAKKCMIDIQMASLINETNNSKNNVEKQIEYNNINNIKVEDYKNLMNIYNDVENSDNIENEVQPLNNLNGKIKNENDKLSYIFKKNDKENENNVNNKNGVNNHNTLQISKNNKYENIPITLQLFNNATDKKLKTNHSWIYDNDSSSSSSSCDECASPLLGDKSRNRFESFNLKNIINMLFGNFEGIEIFKINKDIQYKGVKELLHKLKIDLNTNDELNYHLKKLFIFKKKRGKKIEYFLYIILIFLFFIFFHKILNFLFYFFIPIFFFFWGVFIYNDKISYSGFCNNVNYNVYKYSFTVNSNINFIMSILLNKNKINKGEYYQNVIQSKNKYIQYVCSFIYLNVPIFKQIYEFYRPRKFFMTKYLEKDVREIDKINDGSIGYENFVISKSEDDKKKMRCYFIVQYTSKHSKEYFNLINCEKKIKDGTGTKYENRENRDRNRDENKDGNNNFSAKKMSTMYGISTSIDKQNNTLNNNKYNIDFSSKKMSNIILEMSRTKLGKLIQNCILGLLKHFFKIIKNTFFDEYVKGEGFDIYIIREKGDEICNIEYLTCYDYKSGIFNNYLNVERCRNVIRLFMSNSQNNWEKCEIDFENDKNNFCIDENEENIKLLINKKKDEKEICRNIFFNINNKDISKNIIKYIYNLTRIKYVNTNKYIGLIKNINDIFFIINLSKVFIYLTDKIELHEIKNIKIIEKLTNRHSDLNFYSDDLFINNVIYILSGIKLLHNTFEKSWVFPKKNEKIQGKYNNSYIVITMINESPITFSILTENYKTKTKLYSNIQFVSDSTMSAINIFINNDIIIKNNNNYELKISFPNISLIDLIKGNLRYTFCNNLAVTDSLGNLANIKFIDKYTKCGQFCGIAKRNETITNTLSGNIFDKIIIDDDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUA1</accession>
    <name>V7PUA1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_01547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUA1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0114">cAMP</keyword>
    <keyword evidence="3 7" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="160"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="282"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB61713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="411" mass="46877" checksum="E2DA5B4AEA7C5140" modified="2014-02-19" version="1">MADNDIQTQFQEYSNKIRNNSKNHDNTDSSKESKHGNKDTLSNGLSLNKREDGNDVLSNKDKSANANKDVPLINKNNLIIEECSSDDDETDCLSETNKKDLDSNPLDIEHIEVRQSKRMSVSAEAYGEWNKKKENFVAKVHKKDNKEKKKIREALNESFLFNHLNNSEMETIIDAFFDEHVEKGVNIINEGDEGDLLYVIDEGEIEIYKTKDNKKEVLTTLKSKDVFGELALLYNSKRAATAKALTKCHLWALDRESFTYIIKDNIAKKRQMYEDILKQVTVLKDMDPYERSKVADCLKSKTFNTGDIIINEGEQGDTFYILIDGKATALKNGQVIKTYTKGDYFGELALLRNQPRAATVKAESTCQVVHLERKGFKRLLGPIEKILIRNVENYKKVLKELGIDSSCIEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUB3</accession>
    <name>V7PUB3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUB3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="481" mass="56072" checksum="94E498C6F71F0C51" modified="2014-02-19" version="1">MNGIEDNEKYANYLRNKIIKFFNLKSEDLELTYIKSILNSKTYDLYSSIYLINYSFFENNKNNKITINNVKKFTQNLVDSKNKFTPSNVLENNNNSQKFDEIKNDNGIKNKSIHNSIEYIFKKHDHNPLRNRGSENGNGNGNGNGNGNGNGNINKNESKNINKNESKNKNDNINKNESKNSQTDRSKGSENSHLPKGKKIQNKTNLNEKEKEPNANSLFDKLHNKNVKNCMLGTMTNNDQKKCEHSKTLSKKAEQKEEKSEKKEQSEKKEQIDYFSFFNRKENSCSLKDIIEIIDNENVKKDDSNNDQISQKKKKKNIQICTCNGKNHKIYANCLICGKLFCSKIKFKNCIFCDNPLYESDFINTIFLSNKLETKTSNIITNMKNSNPFLYKYYFDPLNNNLKKAIDMRNKMLKNSINEENTKIIDDSIDWFEDDIKHTLNIHDIHFSCYDDDTKNEIVNKYYDIFKKKISKAILYILISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUB4</accession>
    <name>V7PUB4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="4">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_01557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="4"/>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUB4"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="9">
        <location>
            <begin position="129"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB61728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="315" mass="36262" checksum="E88D89A502174CAD" modified="2014-02-19" version="1">METYIEKKQLDEGCMLSKKKNEAKKCEGQKNEGKKYEGQKNEASKNEASKNDASKNDASKNDASKNDISSDTTQLISIDNPKSINNKNNGEDKKIIKGERIDKKNKEDNNFIIDDLEKQTDKISMNILNILKASNIPNCDILKRTNNRFAKAFLYLTEGYKMSVKNVIKKSIYKRKYKNNTLIKIKDIHVYSLCKHHLLPFEGLCDIEYNPDKYIMGLSKFSRITDIYARRLQLQEDLTNDICNALKKYLKPLYIKVTIKAKHLCINMRGVKEHDAMTVTHASYVSKKNISCFKENINLSKNEISKSDNHDQSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUB9</accession>
    <name>V7PUB9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUB9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="480"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="448"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB62735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="949" mass="113296" checksum="F912F5196FBCF256" modified="2014-02-19" version="1">MENSIHYLKRAGKISIHEKIRRGICIDRKLLVNNFIKDNNKLNILDNINFKNVLNKIEVNSSKLNVNNRNIFKDKKCYISGNYNFEQTLKSVDKLKNSDIEYIDGVLEKVNKINDKDEEDDRCILELKGISNNGENILEYTNMCIKICKKLLKDIFKENNIYIIINIIDTVSNNLCKLGDALELLRNLHNNNNVILKAHEGLEKLTNFIDEINVNENIYNFLKQKYNDNINILNNEHKEVLENMIQSMENQGVHIKEKEKKKEYLKLQAQEKYFSFHASSNFSTNLEGIYIEKNKLLPYIDKNILIKYENKIKPLYKNNKIKKSYFYPTNDYIYILQDSSFLLTLLENIPEPKLREQIYNLFKKTNKDFQNNILILQYYRNMLINYRNFKNYNEYGLKNCILSSPDKVLYFLEKVFRKVLPLFFDELKFIERYIKFCENKNHNNIFPKNEKNEKNEKNEKNEKNEKNEKNEKNEKNEKNEKYEKSVECKDDNSNISLVTPENIFYYINKIKMEKLKKIQDKLNEHLTLYDVLSFVIKILKKSYLLDMISVIPKKGELWDEHILKFEIKKDNHIYGYIYMDLFERENKNQAIAQYTVRCSKNMNTCLKYKWFNVNDEVNFPFFYTGIIKSEINNNVSIDFEQDEKNVLYRQTTSTFLVCNFKIDFDKNVEKKSESKEDLKCSLASDKITNFLKNIKMNLEKVNLFLHEFGHTLHCILSSTYLQHLSGNRSGADFSEFSSHLFEEYLNSHEALSMLYSQKKDENEIKNMISNYVKNKNIICYYPIIQLIIQSIIDQIFYSLSHNSNNMNERKKLIENEIKTYFLGLYYKNIFILDFFPHIHFSKTTHLIHYPSNYYCYLYCSILAKYIWNRTFKNDLYNLDCSSRIVKFLEGGSVNSSLRNIISLVETDQEKIDYYTENPHHIPLDDFFEYYQEGDKQKKYDSFFCSIIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUC2</accession>
    <name>V7PUC2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR00251 family protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUC2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47817">
        <property type="entry name" value="OS04G0686300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47817:SF2">
        <property type="entry name" value="OS04G0686300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB63161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="124" mass="14171" checksum="55FA3C1BD3DDE5F8" modified="2014-02-19" version="1">MNILLNHFSTKMPKGLAKDLKNEQAKTIIECLPSYLKKKDNNLLINLRVKPNSKNTSIYFNADTEVLNINIQEQPVNNQSNVAIISYFSDILNLKKRDISIVAGLKSRDKVKGKHITYNTYVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUC9</accession>
    <name>V7PUC9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Isoleucine--tRNA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_01569</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUC9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="8">
        <location>
            <begin position="33"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="10">
        <location>
            <begin position="950"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger FPG/IleRS-type" evidence="9">
        <location>
            <begin position="1223"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="812"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="812"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="849"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB61743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1255" mass="151424" checksum="DD7501C65BDA575E" modified="2014-02-19" version="1">MPPEAFSCILLCICYAFFFIFFYFFFFSIFQKYVYISNRPIYHSYETKTVLSDSEIIYKNRVCNSFYFFYYFNKIGNDYLLAVLNNIRENKLINEVIQLNNEEIEFCQNNYEMIANCIHENDISNNYINTIINKIRNNLRSNIKIFVFTTQIYTIFNNKALLIHDKYLYRIVKGVYKNFENIYFLICDKSFDMFYEKFKQFYCKKNEIIEFKTIGKIQGKYLNDSTYYNFINNQENQFLLTNENKLNEYFGSGIVHIAPSHGFIDYNLYYKNNKLKKIYLNKLDYENIKNKDKTHKINKVENEDTFFDSSSQNVIDENDDLQEEYNKIIINKCRKNINLIKKYEDKSSQLLILQFLRNNNYDCKLLNQEKYNKININQNNYHLLFFYAFYENIFFHFPYNHLYPFDWRSHTSVQVKSLLQIYIDIEKIKKNKYFYKNIKNINFLNNNNKNYLINTMKDRNDWCISRQKYWGLNIPLKDIKINDNQKFIFKNQIMDVWFDSSVSYLYVLYMCKHILYNIYLKKILSSFKKNYNYNLYTNKFIQKKKKSISHWYVSNKYLNIKTDTQSFYINDIYKEITKDKNISHDNNPILNETNLLKNIIEKKKIFDPQKNYKNIIKEIKNKSNYFKIKKVDDIILFNNKNKKQMYKNNLSIFLCCEGIDQIRGWFQSFFFIYFILNYINEKKTKIKNNDNDDNDDNNDDGDKNNDDNDGDNDDKFSSFKKYLPIKNVIVHNYVVDYNNVKMSKSLNNVISPRDIFIGINNKPQNLMANHHNTYIKMENYQNKPTTHSPIVQNSNDCVTSNCQTGTLVDKSGDEQKWDQKNEQKCEQKCDRKSDPKHDQTNSTLDINENNDKDKSNTNSRKEMKNLKSQFDDFTKNIKDKKKFNADIVRLWVCCYNFLDRNISISYDILENINKYIYLKIYNTLKFLLNNIYDLNFTEKKIEYNKLQIMDKYILYKKDCLIKNCLNSYKNFQLQLLIKYILNFIHKDLAIYIDYSKDRLYIHEKNSINRRNCQKIFYKIIIDLLRILAPITPHLCEDLYQSFRNLKNNNLNKLKKINGKIKSIFLLPFPKIKNYKQVNLDILFLIKYYIHKQLNSYFSNSLLAIVYIYCDNDEILNLLKKFLKNVSPLDNFNNYDDLRFVFNVSNIIICNDLSDVQKMDENYKTYKIPLLTNIMNSNTNENNISDDFFQKNDQKQHDFENISNFDEHTKYANLSIGIKKSESQRCSRCWMYGETVSFFKESFFCPRCLDIIKTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUD2</accession>
    <name>V7PUD2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUD2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="418" mass="49432" checksum="2766894C59C38C9B" modified="2014-02-19" version="1">MHKNMAMLNEFTFSDKNKESGNNTINETFQISQQTNFSNKLENEKTNIIPNSFNITNNKTTEFSEKTNLIAGEKQPFKNNLNDGINNNINSSQDNLNTLTKSNNDISKNVDNNESQEKTENCYLKKNDNNGNITLETKFNFNSSLKIRQSLTEQLCEEISMKLGKIHLCKSYLETYIFEKNPYNMNFMYLKDDVSESKNRVLNSVLLSSFCNMIWSNNIYKHEYLMSKELLNKYFKAIQKNPDKNNYCIVPIYDLNKIKMILNDHEKNIKMLKKRKLIIRKNNENLLFILNIIKNNFAEIKIKAQRIIQRLLFRLDILDKLFILKNNSSFFSNKYEFSKFKLIEILDLFNSFSIDTQLQKINQNIEEFVREKRHVQNFLYTDKEFTTNLKNTIEKNEQVSFKRKPENVSLRSNFESCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWE6</accession>
    <name>V7PWE6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWE6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="249" mass="29775" checksum="28957383667DC07D" modified="2014-02-19" version="1">MPEEKEFMKTEEMLIRKIVHLFKECMYYFMCFNEKDGQILEKYKNQNNRDIKDNSEYELFKSLNDCIIQLHDSRIKKNQALIMTNEFSGIFTPEYVKLTKYSDGFLKLLKENNIKYYDLFYEEMQNNDTYKKKKQHYENLKNSSFVPLTKGEISLAAKKNVIENDQLQNLSNKCIYRDKGGKERKKKRNDGDNPNEQTRKRKHEDDIDGSSEQMNLSNSDDKNVDEKFSESCDNVVKKKKKKKKKKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWG3</accession>
    <name>V7PWG3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWG3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="780" mass="92579" checksum="0F062E7BF8E898DD" modified="2014-02-19" version="1">MNKSEENGQTQKNTAYKTNKKKLCKNIMNEEHPFYVNYDILVKNYKNEKNYIDLNLEINYNLEEIEENNENIKKCIFIPNSKNKGNLCEQKARSKNEKINNQHETNYNIDAKNNFISSKHKKKNNNPNCENRESSRTNQTDHSVSSGEERKRNRDKSKCKSNIKNKNNHESYSSDSNGTYCSDLSENYSEIEKKSMNFSQRITYDDIIPNKINLYDTTLDLNSYMNNKNKNKDQNDVDYISYGVNKLKRAISNNSSLLFADNNTENFNYTHNNNSSSNDNRSDTNHTEIYSPNIFSKQHKYAFLDQLYCSKEEERNNNPSIELARERSSPIRLQFNKKDKILNRRKSEDDILNKYEKIIKIMKYLRRIKTRHPEIETIVSILSNNIKNVTFNCEKMFSSRRELNDFLKKIYIYQIFLLKKVVFKKNYSPKNNYSKICNSKNPSTQKVSFVNINQSHLRDYSEIPDDTKRDSNYLLYYLSKNRSFNIPNNILYENSNVNKDHINKNRQNSVDMLGNIHKYIDKKSTKNIEDKTYYPCINEKDRKNNKNKKYNNKSSDNSDDEKNQNYKRYDNKIKENKKKNHKNNKHNINSDNALDKIEQCQEKRDIFSKPRKNHILNIKNELTNTREIYTNDDNNSNTFVNATLNECKPNKNYLKRIDNAEDRHIMDDPYAKGESENSNFNITQKRGQFEKKYMVLKKELNMNALNLENKCAPIRKNISENEKFPNNSIDKDKKTYVLYYDVNKEINTISNRDSVTHALKTTLLNSIKYILIYMHMFTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWH5</accession>
    <name>V7PWH5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_01061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWH5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB62498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="239" mass="27015" checksum="EE9AF0A0A1BB31F3" modified="2014-02-19" version="1">MKKAAKLAANCLKLCLENSKEGITTEEIDNLAFNFYIQNNAYPAGINFHGFPKTVCASPNEVVCHGIPNLRKLKNKDIITYDCTVYFDGVFGDCAGTTGIGDISEKHKKLIQVSKECLYEAISICRDGQKFSEIGRVITEHAHKNGFNVIKDFCGHFIGTNMHMYPLIEHHYPNGHEQNEYMKKGQIFTIEPILSEGSINIHTWKDQWTVCTNDNSFCSQWEHTILITDNSAEILTECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWH6</accession>
    <name>V7PWH6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWH6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="258" mass="30153" checksum="FFC36F2468A04B82" modified="2014-02-19" version="1">MLKLIKNYTIFSSILFFVHFLTVNCINSSYYHSRICKIKSINHSKPIIYKIFKSAHFIRVPIKSIPINKKSNKKSNKKSNEKSILSNTEQNDSDLDIELENLMKDIEDGKLGNESLKLYREIEKNAAIKEEQTKQIEEQINQMEQMKSINEHNVEDVINNTDNDLKTCVRKAFYNTGVNENDNMNVKKEYSNINKIEKTFDEIDDINSPNENLNINDIYKKINSMKDDDYKSVPFKDTAKEIMKVIKKNNNNNMPINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWH9</accession>
    <name>V7PWH9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWH9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="39435" checksum="A381481A47E9F807" modified="2014-02-19" version="1">MQDINNVSNIEELLCFFDYFIKNGHSITIIWVKFTLNISSDLSQKIMNYYFQKRKEELCVTYLVEGYINNGDEYTYAVISENDIESVKKEGTYIINIYSLQAKNNKVNFPMLWMQDLNEINKRIVSKNGIYEKLNDFVYEYEKSDSPWDYLSCSPTKRDKNVTPKKKLITNPDLKSSIIVSANRSVSKESKEFLALVSPKKLIEDCNILSNSVSKKSSKSSSVSKKPKQNNTGTNDDKMNDQIKYSKIVKREKYDTNIFNEVSTGLSKNEQNTSIAKNDAQKETIKKNEINKRDEYCLFDQDIPDKNTASNESEIEVSQNLSENEHKQDLLQRKYFKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PYK1</accession>
    <name>V7PYK1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fam-a protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PYK1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23902" checksum="B8D98E192B1EB690" modified="2014-02-19" version="1">MNEAVIHLQHHATSTEEYRLISNFDNGTSAYFKNHGGHTIIEKLNNKIPDSNKYNAIVKTLSNLNRVKIADGNVITIKVVRVYTPNLVMIQQRYINLSGSSQKYFYALVTKVETSENTTVIAYTSANINDYNRADKKFYKNTILENANLFKTEVDSEIDIRNGELRKLFVNLFGFLIKKEDEQVDLTCVSSIYDNVSNARNPFTKMCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PYN5</accession>
    <name>V7PYN5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="1406"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1571"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1757"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1596"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1641"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1683"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1757"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1778"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1901"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1921"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1950"/>
            <end position="1964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB63283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2040" mass="235060" checksum="8920F4A775284D58" modified="2014-02-19" version="1">MENNEIIENVPDYTITDDLKKDENVLVYTKYELLYAYIELIINGKDLGKDHNIPLCSTSFKIEDVDENKKEMIEYGDNNELINNNEIEKEGLDKFDRYKNKNDFYNRDNFITRSQINESFNSNNTLNNVNKRNNNLLKNQKFIKNNDLKYVEANIPPMNQQFNNNDHVTNNMTIYENLDNNKNTFFKKNNLNNENPYNNNTTNSNHLGNNNKKIIWRKNERGIGAGPVSWRFGKINSDSQIGNNNNVNNSGNVNGSGNGNDNTSTNGNISKTDLKNSNKSYNNGAEENCQMNDTSMYAKKHNNIKDRNINNNKREDMCNDFDLGNNLPHTENSNSNNIGNNIGNTLSGIQNLGTDSNNRIINNLTDKYNKKKQIYQNPGTKYGNNKNQHILNKNGYNNLDGYISQNYNTEVDYMNLTNEESKYKKYKMFGNNMNTVSNDSIIHDDNKIKNVNEYLSPNITNKNNDPTKLNMYINKKTIDSNNKYQHNQIHAQRPNEWGNGNTNGMYGNNNNFYYTNGNVNAKVGTDSNQMQNRTTNKERKGEYNNSNNNNNSNSNSNSNNNNKNLGKSIQDVENINNDNRKSGKNNSIAQQNLFDSGKLQNNNFSNNNSYFVNNKHLKNVEKKNSKNVIEDDWSNIRKKNIEKNKKLTDDLIWYKINEQFDLSSNKGGSIGLIGGSVGINNYSQNELNNSEILKKIPNQLKQNENIKTNDEMSNNIDVNKNKKEEASTNNNQLLTNIEKKKKGKKKGKNEKDKTSNETEKINKTDDDNNNNQNMKIKNSLENLNPRETSNDNKINNIHKLFDNKKNLNYLLSDSNVNKMFINDKNNISNISNTVNFHNLNRYNNFSEKKEYILNKLYNNTNKNNLQGYHKDLKNSHIQNRSYGNMPHPYYQSLEYPNFENKYDIKKYIEKTNFMDKSTSTNIHSNDNNNHLHFDSNDSLNNIRTHLPNKSHIDVSTIINSQTNNPNFNFTKFRTSNTTTDIPHESILQKIKNKNNNSEQKFNNNHSNGISSSHLSNIHLSQNIHDKYSYPFSRNNEINEIYNNTNISSMKNNVSTSNLSNFNIKQNAQNIQIHNNINTIPDSKIIYDNVKNRENKMFIDDNIYTDNFDKPSMNQSNKNNNIFIFKKIMQIFNIDEKAFNNLTENKKRELITQLMLENFNLASSEKHINDNQMQIQNNLKHLNNNPLYVNNINENTTNKLSYIDNKININDFETKESQFNLINSNNSTSIPSKCVENNNIQADVENNNNNKKKSLNINKWLNFIGISSNKKNKDASKNISDINNTNVDATIQCSNQNDINNSKNRITINKEEMGSDSTPFENTNRSKDNNSSLHNQMTNAQINYIRTHYTSKDKIEDSILLPNEQPDSEKHTNETNQIPSDSKPSLNNNVDISRYIEIINKFNKIKGDVWQYKDLSGNIQGPFSSELMFFWWHSNYFPHDLPVRFSQNMQWFNFNDLFPKGSMPFVIPFIYLKDNLFQNDNNSQNSSYNLHIKENNIVTENGNIQNRMQSEQGFINEQDNEPVENYSNKQYKQFLIKQKTEIESLLLQEKNPQLIEEVKKQLQEVNNLIEKEEKEEKEEKEEKEEKKDKKDKNRNKNKSDGKSVGKSDGKSDGKSDGKSVGKSVGKSDGKSVGKSVGKNGDTDNSLAFEQNNNNEPTSTPNHYDNSNDFSNVKYKKMSKKLENEQSNTLKTNNTKFSDQLDVDQKKRNETIIENTNNQKILDNKSAKNSGDNNTLNYIKNSASNLDTSTNIEKRNVQAKNKNQKNVANQNSAIISSTNKKTEKTTKNKVNKKNENKSDKGEDIGDKKSEDKKGEDKKGEDAKGDDKKGDDKKKTEKMKWSTTGERKIEKLVDIMKGEETKINMQIKIENSKKKQENGNNNKNNKKLGWDVNNIPKNKKNTDNQEFPNLTQGISSKQNKTKQPKNSTQNNNNNNSNSSNNNNNNSNSKKGKNKTEANKNETNDETKFPPIISPKGNKSSNNKKKSNNAEQKEIADLKQLTNLCKLPLDESLLNFLKNFKVMHTHLFISQCTTFSHSPIWLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7P9F6</accession>
    <name>V7P9F6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7P9F6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1141" mass="136172" checksum="DA56488F88413229" modified="2014-02-19" version="1">MNKSINISKAKLKKLNDLFVNATENTDICLNKKKDVSIDPNVTIIPNDNVTKFYDGENNYIQKIDNIEEKENDDELKFVTNKTQSIPIIDPSYIRERNFNEKNKYIDTSFVNNLDKISTDDIDFNHMNNYEKKYYSTYKNEENYSNNQYINATNEYYITKSVEEKIPNTGIPTEHFVYNNDVLQYEDSMKNWTSNSRYLYFIEKEKEKDEKRKETKLKDISLKDSIIPDKYEKMLLKYDFISDKTKMDNLILDVLNNKFEEDTQTYDNTKPKEEIKSDNHEFKQSNEVRKNDNLNAIKKKNKNTKYNRYIISDYLHYYNYFNNDINCSHESGSDSYEYATQKNNNNLISRSIGKREFQNESYDNNKSIYNNEENINIEKITHFIPENFAMNIFLPQEQSIKKHDTYLGDNVEPVLKIKKIRWNKKKIKLEKELLQKYNYVDNYYSHGYCTRITNNLMKKFKKERINIYDIKTKKMNNKAKEDIIEEENLRKMRLNNLLRLSENTIEEQNNYEQEMENKKEESYKTDSYISFDDLDNRSINNLKKKYKMLKKSDNDHERDLKKLKFYLCKKLNKKKYIKKPMKIKKEKTKKEKIKKIIKYSSKTGYNLLAQLQKGEIKEESEEESELSELEEGELFDDQDKNTEDLNSSEYTYSSLTLSFSEYLNIREAYYNDNSYEKIFYPKDPKMNVTYIYDTVDFYHISKGKTLNKRHMLMEMLIFNIKFYERSNFIKEEDLSYSFEINENWKTTIEKKTDDIEELVIDMGNNNENNGIFGLSGDKNKIRIIYNNINQRMLLAKYIKYLNYISSGTIDNAATFFLYETDTLDLRNVQYDKVADSIICLHLKNLKNINNVNIANRSMNVENLCEFLSLPNIKQYSTLNLSKNPLFLDLTFDSKKKDIDCVIDIFKKNVKLNELIIDFVDLSNPLGEYFITNLLLNTSITFLSLINCNIGSDNIKNIINALEHRKVNTIYPINYINIEFNNLTYYDIIFLIKTLCTLNKNFKKLYICGNLVQENIFDVSFAFRRKKKLIEMDKYNKQVPDIFHFDNIYDVKNNLFCNLKGTAELTENSKVSNVTFELYLKYLYIMPPENKLYTIRNITTIKRRYQRFLNIVALHDKKEINIQLNLFSENHVTVFNNLIKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7P9G4</accession>
    <name>V7P9G4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_05637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7P9G4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="124"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="127"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB56161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="191" mass="22259" checksum="B45F0E1E79653C5E" modified="2014-02-19" version="1">MINMKAESNDPFYEAEREVNISVKKLQHMYSNWNSLPDKNSILAKEKYYLMKDEIKYLNKDVDDLENSIDVVKKNTHKFNISNEEIENRTKSLKNIRAILNDVASDLTNTALSPNIYMMDDYNNIAINKQNDDLEVLAESAERLHNAAITINTELKDQQRLLDELENEMDNSNEKMNFVTKKISDYLQTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>V7P9H6</accession>
    <name>V7P9H6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_05644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7P9H6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000006">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="766"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="6">
        <location>
            <begin position="82"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB56176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="811" mass="91882" checksum="B3F37CBD58CAEF2F" modified="2014-02-19" version="1">MKKKIEQNNPRHKKYSYSDESKMQNFFYKSINKNRFYLLFFLFLFSSLTHLAQCQVKKKVSVSEINFDSAVDDVQWCGNNHSTVLVKTIKGKLYRSSDGGKIWTNITSNLSENSSNKNDSTSGHTPETTVVDLIMVNPINKNIVLVIGAQNSHYISDDAGETFKLINYKNKINFWQFHNKKAQWALVSSWTSACFSTDNSSGECMQTLSLTKDLGASFQLIDIYVVQFNWGDVSSHSEDTIYYTRHRNRNGHQQRFSGWSKDVDFVSTNNFGKDVEVLVKHGNKFLISNGYIFVAKLNDVIKQTVNMMVSTDGGKTFNKANLPKDIHEKSYTILDTSEGAIMLHVNHGSTSEKLNTGNVYISDASGLNYTLSLPNNIRTASGECEFDRVLSLDGVYIANFLDDQDEMKDEDLKFTNFKLQLEEEVGPVETNTQKRKKQLTKGKNEEIVRTVISFNKGGHWSYLKAPKVDSIGNKYDCGDECYLHLHGITNYHQYAPFYSIENAVGIIMGTGNVGSHLKYKSDEVNTFLSRDGGVTWIEAHKGPYIYEFGDHGGLIVMSDDLRKTNQIVFSWNEGQSWFDFELGQFPIDVDNIVAEPTSSSVEFLVYGTRNDIGVLYHLDFNALGQPLCKGLWAADSVSSDYETWSPSSGSFTDKCILGRKITYTRRKQTSECFNGKDLKRIVDKKLCDCTPEDYECETGFTRKVGSFECKPTDSTLTIEGCTSSSYFYATAYRKVPGDVCVNGWVPEKVPVPCPDYSPFNNSAKSILFILFIMGLVMLIITYICRNPKFRNMFYNYGNNHQSAYMCYVDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PAS3</accession>
    <name>V7PAS3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_05468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PAS3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB56641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="398" mass="47382" checksum="F814D68F08C4BE90" modified="2014-02-19" version="1">MCIYTYFFFFKSKNVDIEIVYLKIERINISFLTLSGVLTLKLQGVDLRIKPNIHKNASKGIKNKLMKLLKNKEKVHIIDKIKLFSPNGTTDFSSSQKRVQKKILCCSCENYKDIKNMICSYNNYSNIKTYICKDCSILKNKKYGQNLNLLHEQIILKKAFTNYTTDINNITSTTNIPYNNNEIKFMHENIRTSLNNKNIYRDTINGKGNFINSYKQNKNSYSDIKNRHEFVKETYSKLYGNNNEKYVYDTFKNQNYYINNTNIYNNMDMENNNIFRYEDELNKSQNFNFEKNYLTSEHIISNNNFGKKQNIESKKKKTKDNDKRTKICTKFHNSFDHNIYQNSQEIKEEAYKNIDYNIPGKKEGNNCTRNINKLLYRYSNMDNGDYRKIKIDNFFQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PAS9</accession>
    <name>V7PAS9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxoglutarate dehydrogenase (Succinyl-transferring), E1 component, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_05371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PAS9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="613"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB56514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1001" mass="116460" checksum="794608E4431F4D98" modified="2014-02-19" version="1">MICTYIFFYWHFLSDLFRNTLDKSWDRYFTNICNGMPNNSLLDENSRIIYKNRDREYGERHNNLRITYVNEEMIEKGKTGNIYDIARIVQLIRWYQKNGHLYAQTNPLPLPNVVPYTSINNGNNNEKKMTYKNFGFSEEDLKKEFSFDLPSITGFSSYGKKTCTLECLINKLEETYCQTIGFEYMHITDENIVNYIIKRIENDRTYNFSNKEKKEILEFTARAFIFENYMAAKFATTKRFGVDGCETLITGMKELVKRACKLNIDSVLMGMSHRGRLNVLFNVLHKPLEQMMSEFRGKTGFSDNVWGNTGDVKYHLGVEIDHYDEESNRYIHLGIVDNSSHLESVDPILMGQARAQQYYCNDKEKKKVLPIIIHGDASIAGQGIAYETFQMSKLPSYSVGGTIHIVVNNQIGFTTYPVDARSGKYCTDIGKCIDIPIIHVNADDPEAVTYVFGLALDIRNKFNIDTIIDLVGYRKFGHNELDMPKFTNPLLYDVIARHKSVLDIYSKKLIDENVITLKEFEENTKKIYDYYEQVYEQSKNFEPKIMDKKYLPQWEHMVNPQKFSPSRKTGVEKDVLINLGKKIFTIKENFNPHPIITKLFKTRIASLETGTNIDFGMAELLAYATLLSDGFHARISGQDSQRGTFSHRHAVLHDQITYEEYNIFDSLKTPHTIEVNNSLLSEYACLGYEIGYSYEHPDALVVWEAQFGDFANGAQVMIDNYIASGETKWNKQSGIVMLLPHGYDGQGPEHSSARIERFLQLCDDREDIATYSIDKDKKIIQQHNMQVINCTKPSNLFHALRRQMHRSFRKPLIVITPKKMLKMRMAFDNINNFLTSTEFLPYLSEEFEHKLKPKNEIKRIILCSGQVYYDLLNYRDTNNIQNIAIARIEQLSPFPFKSFMNDLKNYPNLRDVIWVQEEHMNMGPWFYVSKRIEAAIKQLKNDDQSWNIEISEIYYSGRDVYAAQSAGDLNLHLYQLDEFLVDAFDLNKKHHMHAQKYINSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>V7PAT9</accession>
    <name>V7PAT9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Snf2-related CBP activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">YYC_05378</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001629">
        <property type="entry name" value="Probable ATP-dependent helicase PF08_0048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001553">
        <property type="entry name" value="Snf2-related CBP activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="14">
        <location>
            <begin position="66"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="515"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="1523"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="207"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="355"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1128"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1447"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1820"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="392"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1130"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1180"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1196"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1452"/>
            <end position="1465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETB56524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1846" mass="216416" checksum="0C037E8AD1BBBFCD" modified="2014-02-19" version="1">MNHTSFDNILQIKTFKLGIEDIQNIGSSYFGENNKKIDRYNEEINLLKQQLSDLNEKMGKSGVIHKVLEPVSAPKITFWYYELKEMKEFQDLVMYEIKKKKKHFKTLSNSCMKYLSNKEKIKLKKQEEEEKKLKIHSKNISSYMDVFWKKIEKLVWEEKKRELQKTLNKNKEMRFKKFVKGAIKKIKNARHNAHELFENNMNYLPCSNNNSENNANSNNENEENEENEENDENEENEENEENEENEEDPECASNNTDNDTKNNINAPPNRPIDSAPKNDNKLSSSKPNHSNEDKELGEEDLTDQEDEDILLDEEMESMDESEEKEVNLLDDEANVPIEELLKKIYGFKSGEEYINLMQNEEEDEGTDTDVDDQVSTQNDSTNPTQNSKKRKLSDAGESDRELKTAKVEEADAGKVDEADVGKVDETDAGKVDEADAGKVDEADAGKVDEADAGKVDEADAGKVDEADAGKVNEAEVAKVDEILECNMDEKHLTKIPPFIKATLRDYQHAGLHWLLYLYKNNINGILADEMGLGKTLQCISLLGYLAYYLNIWGPHLIIVPTSILINWEIELKRFCPCFKILSYYGNQNERYKKRIGWFNNDSFHICISSYSTIVKDHIIFKRKNWKYIILDEAHNIKNFNTKRWNIILSLKRDNCLLITGTPLQNSLEELWSLLHFLMPNIFTSHLDFKEWFSDPLNLAIQKSKIYDSKELIDRLHTVIRPYILRRLKKNVEKEMPNKYEHIIKCKLTRRQKILYDEFINNKKVQNTLTSGNYMGLMNILIQLRKVCNHCDLFTNKYIQTPYYYILPIQYNIPKFCLLFENNYYKDFYLILFLHNEFVSLGGIAKDVRPKQKQNHIYTDSNIQMHTKNNDLTILDSQQFKKNMTNIETLNEINQTKEFTNKCLIEEINSEGSFNLINKFDKNLNYISTDSRDTNYAQNKISFFNNENEKMEEQNSFKSSTWFKEVNKIKDNEHFDYLNYYKNILTNLNKNKEIKRDSQIITNNENDNGKQYLRSNSMQMWNTYPIKYETMQDESMQDENMQDETMQDLCTYVNNEIYKENIPKDLLTYSNEFVNELNNNYDILSIYIDPQNKYKTYDEYLYAMEYDTTLYNTTLQNDNLRGNKQIISNYRGSSNRGRPPRGSHVGRPSRGGHAGRPSRGSHVGRPSRGSHVGSSFRGDIGNQSSRTSINETAEQANANNNNDSSGHNNKNNGSSSHNNSSGHNNNNVQNEDNDTIVRSVETGNFLKKKYLYRYNMKVLNREMQYKNFFTDETNQSYLNSLEHNLWIRKKKEEEINKMKIEKEKKKQLISNYHFIKNSRIPIFGSNLLHLLKTEFLKDQNIVYNHANNIIINNTSMKEVYSEDIPSRNYYNYMDTNIKKENNDDTIENIMNYNINRCKSNECASIVLERLFPTMEYFLKLYEKLIQNFIVINSPFVICSSPNILINSNSKRDDDDDDGDNDNDGDNDNDKKICKVQNYSHISKIEDLIKKIKKATRVYHNAFLKQSIIFPLNKDISLGSGKLFALEKLLSKCKKEGNKCLLFTQFIKMLDILEIFLNHLNYSFIRLDGSTKVEQRQKIVTKFNNDKSYFIFISSTRSGSIGINLTAANVVIFYDTDWNPSIDKQAMDRCHRIGQTKDVHVFRFVCEYTVEENIWKKQLQKRKLDNICINMGNFNSQNNRNNNTSLQDHNEMNKDWFSNVDTIKEIFINKQNNDDDDDIYQDRLLHEQLENPEKTNVRFEKTLEHIEDKDDINALHVTKRERQHELSQDMHEFANKNDFQEAYTLTSYCFNFLNENLTDSLKQQIDEMKMRIEIEMMNAKEDENNSLDNLSNPSDELENYEQVRNEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>V7PAU5</accession>
    <name>V7PAU5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PI3K/PI4K catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_05491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <begin position="1484"/>
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            <end position="1889"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1928"/>
            <end position="1949"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="2157"/>
            <end position="2174"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="4312"/>
            <end position="4335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="4355"/>
            <end position="4376"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="4081"/>
            <end position="4472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="586"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3243"/>
            <end position="3266"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="3386"/>
            <end position="3407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3249"/>
            <end position="3260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="3335"/>
            <end position="3345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="3346"/>
            <end position="3363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="3389"/>
            <end position="3400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB56671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="4487" mass="540259" checksum="5A417871D49EAD90" modified="2014-02-19" version="1">[encoded data, 4487 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PB50</accession>
    <name>V7PB50_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Small GTP-binding protein sar1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">YYC_05458</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PB50"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETB56624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17603" checksum="CBB7BFBB5A09A23E" modified="2014-02-19" version="1">MLKDDRVAQHVPTLHPHSEELVVGKIRFKTFDLGGHETARRIWRDYFAAVDAVVFMIDTTDRSRFNEAREELKHLLETEELSNVPFVVLGNKIDKPDAASEDELRQHLNLFSNSTISNIKGRTGVRPVELFMCSVIRRMGYAAAFKWISQFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PB58</accession>
    <name>V7PB58_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_05464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1013"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1089"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1158"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="973"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2030"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2090"/>
            <end position="2135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="975"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2030"/>
            <end position="2049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB56634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2536" mass="303037" checksum="89144758352400F8" modified="2014-02-19" version="1">MKNVILNVLKSIAINYNITKYVKGFKNIIFLSFKHIIFEEFELNKFSINNIFQNYIIDKYINNFELKINELDSNGSLSPPTNKFTDYLIYLNSLNYKKKELLFNIFFCDKIEIYLDTNNTAYFYDSLLVNIETVYVLLSVAEIDLGRSGKDVKQSGKDVEKSGEDVERSGKDVERSGEDVEQNGKDVKQSGKDVEKRGKDVERSGKDVERSGKDVEKRGKDVERSGKDVERSGKDVVEWVEVVIFFTIVSDEHEEYLKISLTSFTIYYDLRTHLISDTDIYLDKNKYIFFYNYNINFMHKRDCLVEDTDLTCIISKSGKIGKGGKGGKDGTNLDDEDAQRIQKYAIDFVVSSFKINLMHDKFYDLFLFIYKYVYLLCNKNDCLRKVEKKKKKKSKNYYFSKRIANIELNINIEMFTIVFYYNYYHNFQIVLKDINFFIFFMKKKWINKRVRKDWENSSNTIIFNSYILKDLIFFIQSIFIKEEYTKLLIAMYTQKKKFIYLNKKNVNVRRIQYNYNNETELLKCYNLENKLNKFVDIVSYGKNGKNGKNGKNGKNGKNGKRGSKNGDGAKYGFYFRIYKKEKGIKNSKNRNEYINNIYIYIESIYLKIKNLNNIYSLISNIPDKFVFILYYIINKYKNLKENSINDEKYKMKYQRNNDIYLNVRLNFIEVELKNRNMASFFFCVHNLVLYNGNGKLYPYKRQYSSNFKLLKKKQKKIIFCKITNIYSYIQNDQIIHILLYPFNLFFTINNFFKKKMKIEILSFIIELNKNATEIFKDIFFIPENEINNNDIFYGSKQNNNTEINPKFENILINEYDNFITISNELNMLFSCIDVFFDTFNFEKNNKEDEKYDVSSSFSITSVLNLFENVNMYFSFKYVHIYFFFGNNFVELAQKMPNKKVGDKKVSDKKVGDKKVGDKKVGDKRCENVLSFFSSANVKRSGGKDGLGKGVEALYIKCEFKNVNFICNIKKDDNNNDNNNNDNNNNDNNNNDNNNWSIDKYSISNKLKIQNFRVLYNFYFFPINIETFIMNGLCVYILKDSISDKEIIKIKTNQGLVKKKKNIFILNKCMLEYADKENILLNRCKWVVNLSYINIYIYSFFINLFYYIYRNNKTKIFEKKNKSNNLNSIIKIQTNYTKMLKHIKNISNDLFISKKIFKILIYILIKKINIFFIFYNNIYSNSDNISKFYNTHLVLKISYFFTKLKNEIINIKFRDTTLIEDYPFHNDNFVCSQNINKIQTYYYIFKPRICIILKDIVFTRCNCFMHELRWNQNKRSEKCFKNEKTLKCGKIECVMTKWEDIINNFGKKKKKNLIKIDEINIKMLNLYNSILFINLYKIKIFNYFNLIEGFNIYLELFLNTFKSSFFSKYFHIHNFESDNEYMIKFDMKEKQKSCKIQNNNINNKMENDALAIDKDIDEDVINNTWSEIVYKMCIFKKIICCVNLISYNHILFSSPIINDDKQKNQKEIINLKITKIELILKRNYIKNLNKYISYFNYNLYTNIYGINIFIKKLKKKYILFWSNFLSFFSKINGYIPKNAIYHDFETKKKKKKKKIRESYVLYKNNCLKYISWKNTSIPLFFKINKQIKRKILDIKFLKKNNNFINLETEQTLSNKFPLSVKLKLTSYDIKNRQNGCSKNESAFYLFLNEVSILSLVNMYVNTVNLFENLSKIAKMGLEYSEIKKKHVEREDKTVEIENRECEANATESVSFLQCLERFKIKMKNIFFLFYGCNMENFIGFYLKEINNILYIYNLKNKKNTNEHEYYFRYINKLTDSVLFTNNVYFNSNKNIYIFEIFNNLANKNNLNYLKGMFYFFKKQKIDSNLLFLRQKKIINNIKKKKQKEYNDKNKKIQNLSIWWDKQLKIGKKINKFPSFIYSNMLLYKIIKLNKKRRISTELDIDNKNDKNKMVVCVKYYLKNKNIFVHIETKHTFKNVCIYFPLYTIIELNKMIDALNCPFIYKLYLSTITNSQNNDNDYIYKQKKINISFDFKFCLLNFKINLLSGYTYSITNVKENDLTKYGIEFRDEPRKSSKGDILKVQTREKSEKNEQNEQNEQNDDGDSATFEMRLEKQKKKKEKGKGKNKNGTEIKCQQLGRSFKQKEVKKNEIEKEGKNILEKKQNEMNVNEMNVDEMNVDKMNRKKRAFLYVFVLKTDINIDIKNKNKKKKIKKKVINNSKKNNVTFVNMNISFAHLNVISGLLYIWINEKPFLFNIIRVQSLFKYLYEYNNSSKYYFNMSRNHKFRLRRNENLINQIENKNISKITTKMNKINFIIMREYCTYNTIDIMNILLFFQNISYYLNWGKRSCKKTKKNIKNKSNEHVKEINTDLASSYDIYNNRKYEGVDTSQHHISGDALDIYSTKKNETNIYGSNRESYYYEEKERKENQRIVESSHLSYNNEVIKLENNLNEKNKKDRYRNKGMENELKIVDEILDKDLCANEKKNSNVNYCLNNQKKKAISKKNVNVIIGSMSIYINNNDLLILNLLREELLFIQKKLKGAKVVYSCKYNYNGVMISSKFSKKKCINNQKKKKKKMKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PB61</accession>
    <name>V7PB61_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PB61"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="714" mass="82949" checksum="A5977CD81BCAA590" modified="2014-02-19" version="1">MQYLNKHIETAKKDSITLKKKLKKSTDPLFYSTLEQKYKQICLDIENKKNEIKFLKDIIRKNEKLLDSNKKKPNKVALEKEYKNLLGQQSNLCSRLIQLQNGNKLYEENISKIDIQLEEIKKKMNELKIDRMKENENPIEECNNLSKDVLEKRIFTLNTKRDELKKEKNNVINNLTSILTKLKKQISNLESEKNSLLNEEKNNLDKCQILKRTINTKINKTENKIKVFKKKTILEKREDNNDPVRSEIIPQKNKPYNSNENVSENETNFIKNLLDQENNSYNINKNQIIFPKEDDKENNKDNNASQISNLNNASQISKLNNASQISSLNNASQISNLNNASQISNLNNASQISNLNNASQISSLNNASQSSSLNKKNKYFIPVFEEEMLLKLQEKVNEKLGNNESDIDVNEIDPEHDNSDDVHSNQGNVNDVVLSEIDELLPEADNSENVDVENKDPEYNASDFMSKNSSINNKTHNEYPDKLTNNEEHNEEHDEEHNEEHNEEHDGEHNEVAYSLTDSNISDINKIEDEEIHQNVKESEKEESNNMENEGNNIYDESDAIMNISIKTTSHINNVEDVKKNIDAEELEQDNQIEVSVGTPAENNVISEYHQDDYENTNRHVESEEVEKDEEDETDEKDEEAEEAEKDEEAEKDEEDEKDEEDEKDEEVEKDEEVEKDEEYEKDEEYEKYEEDEKDDVVGDKTTEECAQYGNHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PB77</accession>
    <name>V7PB77_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine cyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PB77"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270:SF1">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36316" checksum="C7E3DC4C0A728ED2" modified="2014-02-19" version="1">MANKLVARKKIATHIIRENSLVKKKRSLKRVVILVIIICMLIAATVLLILHFVLNGNSNYPIDIGIYSYEIINKYNHIHDPIIGKQANVDSIIHQRYINNHPFTQGLLYIDGNTLIESSGLYAVSYLRKFKLNTGATERYYNLTNNYFAEGIALVVEPETYRKFIFVLTYKENTILVFDYNTFELYNTFEHDLNGYGLTSNLDPIHSIEDLKNGKFANYQKLWTTSGSEFLYELEIPNNFKKTNKINIINKKKVTCAGFTIKHINELEYHLQEKTIYANIFMTNLVIEIDISRGSCLKIINLSGLIDQNTNKVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PB80</accession>
    <name>V7PB80_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PB80"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899">
        <property type="entry name" value="DOMAIN OOKINETE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899:SF1">
        <property type="entry name" value="PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="406" mass="47037" checksum="69443EA3BC1D5A03" modified="2014-02-19" version="1">MNLLHAYIPSYTNQNLCIQNGTVQKYNSNSNLNTNSNLNSNSNSNSNLSLNNGSNVYMNPFPISHMNTNMLLGNNNTTVCMYNNNTIKPQFGIDPKLYSREFNRSNFNNVINKVPIKYESTSNYNRYNNNNNNISNNYLKGQDECLYKSCLGSGMFSLQYNKNNKKNNNKNVAHDIYRDNCKRVIIFDLDDTLIPTCWIRDRLTSKYSLSYEQSLKEVKKEIQTNKNYNFESSLCSVICLSTSISSGVFIVTNARSDKWIETVRWLFPQFSKVLDEYNIPIIRTDQHMEPSPLKMYEYFRYWMNAKKKKFYEIIMDHRNLCNQYISSKIDFISLGDTEFEEVATEELQMSNKNIINKAFNIKVQAGLPIGEFIGQLKLIQVALSIITKESYSYKYLALSGSVQIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PB91</accession>
    <name>V7PB91_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spen paralogue and orthologue SPOC C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_05704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PB91"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spen paralogue and orthologue SPOC C-terminal" evidence="3">
        <location>
            <begin position="189"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="349"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB56255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="428" mass="50125" checksum="AE6645B2A628ABA2" modified="2014-02-19" version="1">MGNNNPNNNNKFHKKTNRTNQFYNNQLYNNRYVNNNNKRPIRNGFTTGDGLINQHDADINYSREYEPNKRMRMGNFNDNPNLNNINNDAELNKLLREYENKKDSNNNEVENIIQTLINGITHKTPRVKLFLCDHLRKCVQHVFNRPCINIPNNNNIANNNNITNLNNNPMSNLQNYKNINEFEKKKIYNNNNTILWRGILEMKNKDSLNINAYGLNGDVNNFLNNNIKNITISHRKKMKNLPKIEAIYYFEIQNEKDINIFESYKNYFNNKDRVGLASANENWHFYIIFPGTPIFNEIINANNNIQISFNNTFIGVVSYNPQILEMNIPRKLNPSQDDAPIINMPPTSNNSIYNNNNYNNNNNNNNYNNNNNNYNNNNLASNLNNIEEHKKSESEINTNDQTENDDNKNELPNWLNQFSSLAAYLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCW0</accession>
    <name>V7PCW0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhoptry neck protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_05642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764234" description="Rhoptry neck protein 2" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1754"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB56173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1874" mass="215723" checksum="D99C69AD5DFE3DB7" modified="2014-02-19" version="1">MLKATIGIILFICVNIDIIRTTSRDNVVNTKFVRQKSPTYDPNKKGDVIFYMPEHKDEIHRANNKSANINLKNNPPRNINIGYNTAPGVNHGFGQFSGKSSNMNNGINTYKNQPKHFQSMNYQKNGPFGNKLEQMNIPANLYNNKNNSYYSGSNNGNNNSYGLHDNKISPIGNNGRPGHLISHFNNPNQKLEFLHGFDGLFNQNIPGMNHKGNYGFNGVNIKGQGKNEKFDNYGQNLGLNKTNEYQQMINGNNMGSDHIYESPNFVNGNNMGSDNAGEYQRLVNDHIYESPNFVNGNNMGSDNAGEYQRLVNGNNMGSDNAGEYQRLVNGNNMGSDHIYESPNLVNGNNMGSDNSGEYQRLVNGNNMGSDDSGEYQKLVNGNNGVIPNFTGNDQEIFKNIRGLRPVNHEELYKNKMNPLIYNAHGMQSGNKNGAPNSTSDYVSDYNSDSDTDSDSDSDSDLDYDSESNESNVYKIKTNKLENDNKDGNGNVNDANYYKNQIDIANKNHGNRYNSENDYGDSMHSDSALSYERDLSSGNRHVKEGSNDEINIFYRDNAQDRETKEKLMNSSESDKDVENPLNITIPEENVNYHFSNYMNFDKKNILTSNEEELLKMIGPDFSKEVSNYCSKKSIFPSNGKYLDVSFEYSKELGKLREKMMSGLFKKKGKLVTKENNILKQIENSLKMDYLERQQGYVNYGSKSNELKNDEESMLSNEYNKLLEEYICHILSNNPGKTQFEKLYYHNLALGEIMKPIKTKYKNAATLSIALNYEIYIVSSSNIYLFGHMLLLSLAYLSYNSYFTKGTKSFYSMETMLLANSDYSFFMYNEMCNVYYRPNKSFKKDLTFIPIELRPGRYTTYVGERKIICNTLELILNAISLININEIYNVFHKNNVYGYENSVSFSNNAIRVFSQVCPRNMEKNIINCSFEKSTLYKANAPEDTNQNEYQRQNQIKNQNELKKAFDLLNTFSEIESFSNNNYQNSYYIKLIMEQNLYTDFYKYLFWYDNRELIKTHEINGKKNTKKTSNYIYDQYIKTNRLLEKKFNVLSKHNLKSKGLLAFHSLIDRYSEFVKNKKIRNLYLKFVSYARHFLFMNNTMKSLNKSDLDFMKMIFEELQNETKVPLKLIVRGNYMKSMNDIAKKENLFFINLFILSLFSNKNPVKNFYNGKREMLKASLSEKFATSTSAFIPHKLRRIVVGMKKGFLKRKLLKTLMKNRLLQHIPIDLLENIMTTFRFTTHAIATSELAQNAHRTSKYLNSNNTSKLEFAKTIFSKGGFPQYADKLMEKWFSKGFEEYKKEKIDNQNMENEVDKELDQIKEMFIPGSNGKHNSNTPPHLIENINTDVNNSLDNQDKYDNTLGKQRVDKLIYNEHDKWDHYINKEYVKALGAWIEIHKKSNNVMENILQAVEDSKYLLENNIEDSIFFSRTFKATKQSAFRNVLNKTLSLGKMLLRKPSFKVDHALWFGATINMKKGFALLEKVSELHKLIRHEDESWLINEAFIEIVDHIIAISTPSSISSRAGYLSNPGMFHINPFYHRLSNEERLKELQQYMCYDHCSSLWKMLSTFALHHLKNPDSLQTYEDKFSKNSLGNKMTDKDFVNNFKMILGGDAALHFYDNLLPKSMKKELKSMKYGVSLSFSFSLKLAKMVFGEMQLPHLSHMFYAQAPYFGHFIGKWQKERQQGRLKEILGAMTLGTLSTYTVLSAMDITQHATDIGMGPSTSCYTSLLPPPKSICIQQTVKTVLTNSTLASMKSVFSVGLFAAITPYMFAPMAGLAVWSVLKSQFKVVNRIDMALKGALKNMWNKFMSLKGIRRLKNVFKKIKTIKKKMIQKTEKNLAEIQQNPEAEQNHKAAVNEIHNNTRGNYHYISYAKIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCX8</accession>
    <name>V7PCX8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF3">
        <property type="entry name" value="SYNDECAN_NEUREXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1404"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1449" mass="171736" checksum="04632521BA2923D7" modified="2014-02-19" version="1">MSTGWNFNFGRKYAERRRKEELNYINLFNQNEINNLNENPEVFKEGLNCGPAGRNALIRWIEYNYRLKNDEENSNPAVRACKVWRQTQSFQDVALSGLMDFLKFLNIPKHITYKHVFKNYLSPKFINKVKSVEKSQKCLTKLAKKMMLMFQVREIQPLFSMVLEKINIIPISILKVLVEDTPAAKYFYEITSINVKRKIWILCPELFFEEVEDIIEEIILRMKLKNSHNYITNLINNIIELIGEGNEHIFLYNLFLHIIRLKCLQTILNEKEHNSSNFLHEHTPCAEKKIKKNAYSTNVNNKLHLNKDINEEIIQSEKDSNNTPENIKSNSEIDECIQENNDSGTVEAQNMHDSQDGASSCSSHLSEHFETKLKKLEAIFDKIMNNNKNVKDEKKKIIKCNNNSKLYVIKMHEYSHNSSSFEYLQMRENMDISENSTCHIHKSEIFSNIIENKEVNNMNRSSSDTIYTNSFHYDINKKKRGVSDNIISNITTSNNINKEKKEIDEEDKNKSTNRKFDKDYYKKKLILPFDSMFYSNLRLLFCLQYKEKYNLKDEEITKIDKYYHIVEFVNNIIKDGTLCFSDELKTQEIIKKTKNSIKIKNIDDLCEYSLLFNNILLKYSIINGICFNFYNNNFDLLTQKNNMNFWASIFYFGIYNNFFVLSKYAIDTIDYKHRKKNKKTKLYQQNEESAILKTNNNQNTESYDNLNYTHENSNIEKKKNETISSNFMSEQTGYEQLNYEYEKNDKKNDEKNGENKYGMNIDENNYGMNIDERNMSISKKRKTGQTRWESEGCVEFKNIFEGDDKLIEYESGDNKNVENNEDVIVKSNMSYYNKLAKKKSPSSIETYDDNRYLDKEKRKEKNKNYKYMNIENKKEENHVKYIHESSKNFKPKNNNDDTDDAEIGSNYNNIFLMEEIKNKTHKLFMNGNNESYLKIPLNKILKYIITSDNGNNDDFLSFFNFFSEDSDNKKKTKNIKEKNSILLLSALLNIPQINYLKIHIFFTIIDEFFYEEKTNTRNMPTDYYNTKCASDHNENNTELKKSEENKKSKKNETSNVTPSTNKLESNNIERQNFENNSQNLGTFIANNTLTTSNNSIPSPNNINKNFNNSDKNKIGETINNEYVSMKSNCDTTPSNDKEKNISHQKEDQINSPEKTNTANCNIRRTSSNNLYGSQNKKDFYHIGDKLLRNIKDMNNEISRSYFFTNNIDMKCISDILNCSNNDEYKDDQKVENLNTIKNEKINIHKDNDNLITFENDEKKRVENNIYKNTYYFYEISNKIIQKSDNFKGNSKIKKYLPYVLKTSFISLNFLKQANIINIYIKYMYLYEYLYHMILNRILHISTVNSLPFLQNVILKDLSYYFEDFKKSKIKNLWKFYLYSYTLIDMNKNNIYLISKLFHNNAIDYFIKLFYSLSFYNSIFSVLFLKMMETPLFYKNIEHKKTEILQNLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCY3</accession>
    <name>V7PCY3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CAMK protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_05661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCY3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="42"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB56198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="302" mass="34892" checksum="D6DC39BF398015DC" modified="2014-02-19" version="1">MGVALSKRKNNPDKNLKNDSSENKRQKKNDEHDSNLEFIKKYKIINKIGDGNFSKVFCCRGENKKKCAMKLMCCPLKKTSHYNCFKRELFIMKTINNKHPYIVKILDYHEKIWKKYYIVKLILEYCEGGNLFEYIKINGSCTHSEARVIIIKLAKTIQYINSLKIMHRDIKPENILLRTKDNIKSVVLSDFGLAKITPSNQSVVKSRSVCGSDFYLAPEIIKNKEYGIKIDIWSLGVLIFFIITGKVPFTGKNANELYNNILKANIPELLSKEKSLNIQPGLKNLLENILVHDPEKRFSVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCZ2</accession>
    <name>V7PCZ2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCZ2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF87">
        <property type="entry name" value="CRESCERIN-LIKE PROTEIN CHE-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLASP N-terminal" evidence="2">
        <location>
            <begin position="617"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="809" mass="94412" checksum="C3760448A66E817E" modified="2014-02-19" version="1">MPTLGHSKYRESISTFIDDTRNYKRKSIDEQDDYSIVEDLLYLKNEGNKELHNATNGNFYANLELGSSHNNGINIKLNRDNQFIENKNINEVNNVKNYKNHIDNNDYTFESPLNELQRYQLTLLKKRNPSNPKLPKEIEETSKTYNAVNLQHSEKYKNKNNKDLVNDIDIISIKKNTVDLNNIKGVKIKEKPILSNLITNKNDNNNHLSFSEIYETPVCDNNLSNSWKNINIENEKKVKCEHFISSNEKIKGSFEIKKDNDIRQDNTLEYCDIIKKRNIKNERSDIEDIENNSMSKDIKKYNNVKINERYKKINETSLDEMDIKKRDINGMDNNYENCIIQMKNKKNNGDKLLDEQYDENKKSILYDSLHKNTIKEISKNGYKMEHNYIMPTRDKYYKGMLEECDSKGQETRNIIHTNKNLRNNNNINNNKYIENQDRNTSNKINNDLSVSYKSDQNVIMNNSNKAKNKIKDEEHIEPHTLNGDLNISIKKNNGCKKGLVNDTTYIQDDPEIKIVNKNKTHTHNLSSNGYRNVSKHTTKSLNHSVNVDTNIQDNNYLNVKEKNSQSEKKRTSISRNVTPNKSGKNVSVCSKIKNDNTMTYLTYEDIKNFEFELSIDNINDMITKLLEITKDQEWKQQIENLINLRTILKYHDTLFFNNFIKDLRKICRSIVELLNSPRSCVSKNALLCLTEFYSIGKKKMDNTLDDVVMPCLKKAFQTSNDFLSNAANNSLLSICNSCSESKLISYFVKIITSKQKTYNLICLKCLIAVIIKFEENISKYKEINKLIEALLEVSIYNEHSIFYYYMLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCZ9</accession>
    <name>V7PCZ9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_05450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCZ9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="385"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB56612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="460" mass="52238" checksum="00B000CED8AA40D4" modified="2014-02-19" version="1">MSSKMETPKDLSEMTDSDFSNIEDKTDDKNEPSEQNEKNEDEKKNKKKISLKKPKKKSSISSKTSQKNNKKVIQNKTKKKTNGLLACPPPPTHPPPPPPPPFIPKEKQQNWKLKKKTNNSDINNDIISITTYPANSNNNNNNNPHYRINEPHMYNKSLSIPSIPGPTPPYPSNIYNHPVSNINSPPCTNTNIKVNLQTNHNYNNNFKKNYKINNIPESESYVMTSPTLISSSAQQTNTPMNIHVDRKHTLISNNSITQNKDYPYIDIQHNNNNMLSFPSSPKQPYSNISIPPNPNYYSPNNLRPTDYIEDKIYYPNYQNNIDHNNTPKYYQPVVNAWNGAAPPPIPNNPYQGNPKFSPHDYNPEKMNYKDKPIRMDNAPYDPKPHNIIITNIPKNLTSRDIMETFKCMGNVLGAGIMMTSKGEHSGCAYVTFPNIEIAALAASRYDGGTLNNQKIKVFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD81</accession>
    <name>V7PD81_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">V-type ATPase, F subunit, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_04399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PD81"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB57521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="90" mass="10246" checksum="C1344D94A69F0A24" modified="2014-02-19" version="1">MTSRRHKLFNETDLKIYIIGDEDSVVGFLLAGIGFRDGLGKKNFFIVNSKTSKSEIEEVFKEYTSKSDCGVILMNQQVIFQKNNNILPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD83</accession>
    <name>V7PD83_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PD83"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="610" mass="73188" checksum="E0126350122C0CBE" modified="2014-02-19" version="1">MKREDLKISISSWIYKNYKIVDIIKMILKKGKNSSHKYMIKDNICHRCFIKKYIDYPNNNKIKGCINYPQKKIIYNKEDLIKCVKYISKKIVKILKNSEIINICFVFKYNIMIGFQNTCIYLINFPQCNIKKNRIFYNDNNEKTLLFLFNKRIVKSIKSVNDYSSIIFPFSISKECQKPIYLKKKMISYIKNVKFKNGEMAKHEKYNKKGNIFNSFDESCKSDKYSISSKYKKNNETKFEGKVSKNHNKNHNKNIEWGKSKKEDILKKYSKREIIFHMHLFELLIRLVFEKTKTYFVFFINKKTYNLDFYKNIYYLNMCKIVNIRICGKDRVKKENKKKECEKKECEKKECEKKKILEKLRDENNNYKKIINEKDKLITNLENEINEKNQLVSNIKNEFAKYKSENSEKIKTEILKRKESKCIISKNDSTIITNNTNQQLLKNNNYIKKLYNENNLLKERIKKLTKSNDEDVNTNHDKKISDVTKLSKLCLYENEEKKKETEKCDKLIFYLKAFLDTEQKLYTADVVINIQANIIEEIKKEQKIYFENIEKNKLILKKEIESSFDFIYSVCEDIQTKKEKICLTNRINKLQDCINDFLSHLNKSTKTEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PD91</accession>
    <name>V7PD91_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_04406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PD91"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001527">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="337"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB57531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="577" mass="67244" checksum="74E63CE3AAF236C7" modified="2014-02-19" version="1">MIKIKNRINCTKIAIKFCRTYLEFYKKIFFHIIRLYLYWKIMNINEEKRIPLCCEICIKNEKDISNEIIKVAAHKWLFSLGITITLGRHDPNKIMCEKLSNYCEYIVIEPAVPIKIVKEYNENCENNIYGTLYTTHYSVYETNSHININDNKKDIDNINILNSYEKKNYENIYNDNNLKLKKQNTSNGFNTSNLVSSLATTQSIAYSFPMVNDIKNKDTIKYPSNLLFTVPIIGEKSISSMEEDPIILPNFCCVVNVVTYYKNDDFMEEQFNEPSENEDEEKKNIPIYAQYILPHPRFHKLWDSLYYEENIKRDLLEYVSALMLFASKKIDCNLINYNHLVLLYGPPGTGKTSLCKALANKICIRLSNMYTTGILIELNAHTLFSKWFSESGKQVLKLFNKIKKIINEYEENDVFICLLIDEVESLSADRKKSMDGTEPSDSIRVVNTLLTQIDSLKYYNNTLLLTTSNISEMIDDAFIDRADLKQFIGLPNEECRYEIYKDCIGELIEKGIINYCSKIPSYQRITKLLKNEKEKSKDEYVYGSKLMECAKMSSGFSGRCLRRIPFQAYAYFCQAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHA1</accession>
    <name>V7PHA1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SDA1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHA1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="2">
        <location>
            <begin position="346"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="960" mass="112887" checksum="25F4ED8D0376C69A" modified="2014-02-19" version="1">MNDVKAKRQRVLNHLQHNIYKNADLYSTEFYEQFDKFLFNYSMLLLNPSKKNELLCSQLSFLCYTSHFFSKKKNEKKLKKVDAEKGLTNQNGINGESKEDGERKENEESKENDEKEESDIGNYSDISIDFGSSSDGYEDENRSCNVDANSDSSARCSNPLQNQDNIINLTNEGTNNCDINEEEIVFQKNIIENKKKEILNRLSEQAEENITLITQREEHNKNPLLLYNELNEYINLLMIKNKEDINYVEELYFLCCQLVIQYKNNLYPSILLSIVKTFKQIKKYIDYIKYIQILIYMSDISIHKIKGYIYKCVSNIVIYINKKTKDEKLKNSVLDLLHEAFAENSQRKIIKKKYSSNIDNFVYFKNIKINESINNFACSILIEMIKKNIYIQKKKNINIISEGIFYKNLKIVKCVAYALLGKYDIKEFSIKINKEIENKNKNIDELKSISNQTHQKMTKAKIKRLHLKKGKIMDELSNNKNSSDDEKDIYASNYVNYLFIDSLFDPYSFASKIFNIIYTKYRSNNNNNIKILLLNILCRIYQRYKIIEENFFIYFENTIYHLKNKNTLSKYLSIFIQSLHDDIPIQFVQRVVYVLIKKFLILNLSEEFVYLIINSIIEIIIKCPNSLNDEIFDSVLIFKDYKNKNISILIRRFINVAKNTNPHVMSKKLWDKKTAMLVQREKLLSTLPSTRHDQSLLQYSYLLDRASRGKRAREEGDEVDEEEVDEEEVDEGEEEADTEEEEVDVEEEEVDAAEEEADAEEEEAEAEAEEEAEADVEAEAEAGGKINGSRKKARREKKIKNELMIQKKNEEILSERILTDDDFKKLKKMKEYIENNKNIVLSELAEICNDEYEDDDDTDSDSEKEKIITEDQLLYKKKLKKKEIIKIKNTTNGESRFKTNKEKEKKKSVMMLMQKLKKKKSAITQYGKLKKKLKGKLAARAKKRQIINKRVAKKLSRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHA3</accession>
    <name>V7PHA3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1551" mass="177441" checksum="1C04EE374DA2CE05" modified="2014-02-19" version="1">MNEIKIKSSIKLQNNDIHDIVATVNLNDDKFAKKILNKKKELKNDDNDDGDFTNNLYSILKRDNKLFDKFLQNKNFCLKIKGKAKKRIGNNVLNGHNDIFDNKTTVGQNININNEFKRYISSDLKNYKGVKFYGKIKKVKNRTKHLLKHSQNCTTQDDSSSYLKKKSNYELIEECNKKINNGHSKSGHIKNGHIKNGHIKNGHIKGGTPIINLSSFIRIKKRIIKKKKKNIKKCKKNKLIANFRETKKDKVLRTKWSGNKKINERKESGIIYNLDGKKKSEIIYNLDGKKESGSGSVYNLEGKKESGGGSGSGSVYNLKEAKPIKNKKETERLSKRNKCPISIRLNYEKNKLYFNCLFKNIQNRDRKQVSNDMNMLDDKTIGSKSICEIDEFIKNNKYVMKENIKNIYKKKKDSDLYSCNNSNYSRKNNNYQNKRNSCHKYDETFMSLSESGESGKNGSLYKDVNFAYPFQNGEEDEKKYINVMGRYGNIKRSSLVSDKNKFEIKRNSEKVPNKTSLHLDNTDLEKQKKMMKNMMKNMMKKMVKKMEKDANQNVSIFLKHPLISKEQISTNKDVDTDHIKKKNVKSLKCNVKRDSLTSIHSGFSQNKSVNEISDDFKYYSNYNFEKKKKLPFLNKSYTNTIFKTEDYKIEDWKIEKKTQSLSVANILDDNKIKHNSLNSDKKLLTLNMSNILDKKKKKNFPNSKFSNSFIGSRNRSGPTISKRNSNKTNKYNENNQIPINDNVTEIKTINGNMDNNNPSFKKLNINSKLILGSKIAEVRSGEKGGEVKNDEVKNDEVKDGEKGGEVRSGEKGGEVKNDEAKDGEKNDKQNDEMVIKFVPKVCKPASKGVVKNLVKKYEHKNGVKQNVNELKKEEKEGKEEKGEKEEKGEKEEKEEKEEKEGKEGKDVNDNDATIGGKEKSGHNDEAKNGEVKNGEVKDGEKNGEVKNGEAKKVKDGEKNGEVKDGEKNEEVKNDVKNDGKNDVKNGEKNDEKNVVAKNSINKVLVKKMMPKIPSLNKSMVKKSVILKTGKKETHDNEQDDKDSKKSEENDSESNSNKNGKNGKNEMVLNKTKSEINEVALNKTETAKCDDKEKVKVHKEISLNKNVKNIPSLKDLKKEKDKNILIKTDNNTNERKFIEKAVKKNIEKMLEKEEIEKDEESEKTWDPTDLSLFNTSETISKIMNLKLFSSVQENINDNIEKSFALNSSEKTAVANAEKEEEKEEEKKEEKDEKKDEEKDEKKDEKKDEKKDEKKDEKKDEKKDEEKEEEKEKESGEPHLDKTANTSSKNQEQSTSKIVSKIGISKKFAFKFPLKASKHCVSKGSVEAAKKAEEKVEAVEKVEAAEKVEENKDEEKNEKDDFVTKKPNILKHPLKAKMPGLPKNNVEKALIKKNNFIKKLNNIKNVLPSKELPIKNVKIDENVKIDENKTNDDNKNGDIRLNPDSIKTDNTSVLTSSINLDTANCHTNNSAEPTNSVNKHEEEIKNESNNEEKKINENINHIPSKPIIKIVPKFPKNVISGPIKTNFTKDIDSLKKAVKTKPPMLSKYKPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHA9</accession>
    <name>V7PHA9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHA9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="818" mass="95246" checksum="D8A7A65A42017B87" modified="2014-02-19" version="1">MTKKNLDESSNNFQGKICKLESVINGKNNEYMNLKANFEQVVEEKNKLEEDINEYEKAIYEINENLTSLKEAHIEELKEIQEEISNLYLEIEKSKEQLDTMQAECEDLRKLNHNKSNTINSLSKEIEALKEEKKQREDEMELIISCQNKVKMEMEYMNKEKDKLKDNEEKFLMEKKHFEIYKQQLEEDKKAIEKKNEELGKEKDRQENNMKNIIIKYSNLQKKVDDLSEDNSNKDTCIKENQNKINLLNDENKVLKNEVTNLNSKMQELKNELDCEQKKNTELMENVDNKTNEVSQRDSIIQILYNKLKEQENENLIFQNENISLKNHSKKLNTILENRKKEMEHIENGLCDKLTKLIIRRKIRDKDDLCFDGHPQSMLLKILWNGYIDICKNVLRSRDSYLFTQNRNHKFIRVYDTDMFLDITQESTNKCSISYKSETRGIFFVNDDESKNMIYVGPFSKYSGYNVAVSQKSNSLELISKSRNSYIFEELFTTKKGTKLILIKEKESGKYFGGLHNNLYFEKQKQKQNGVDKSYYNDAVNKLIDYMSNDKEENASMVLKKCNSEVKIENVENVGKVEKVGSAENVGKVEKVGKVENVGKVGSGEIGESGEIGESGEIGESGESGEKEVIKGNEDSNKINVDHIKEKNDNKIEDENVHKYNIAKDMLLLSNSNCNSTTDNDSNIYYDMNNKYSCQELGQNDEDFEENNSSLKKYIGNNDSYNYNNISMYKCYIANSSCFNNTILTLTENKDEAILFEVFNYEQIVEYDSIKCASEYILQFLLNLKKTSSQDLSTISSVKHSNFISLNDEDWNIIPAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHB5</accession>
    <name>V7PHB5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHB5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="362" mass="43180" checksum="29EA934E8AB90C7F" modified="2014-02-19" version="1">MVINQGITKCQNNEKLPNNNQKSNNQMQLCKINYYDNIIDLTKLENTNGKNTILEKKKKDYIKSDNENAVKIKNLSISKKNQTPPLIKKTNKINNNSKNICDDTSHTSNVSYIMKRTINRIKNVSNNHQNILKNNVFKTKFFNKIYNAEEVYKMNLDYDSTLSNIQKKENEKIKMLYFKYYKCLFCVDEKDIEHFCFKKYDNDLSNNYCKPCKKFFKLIISHGMKYKGKLINLNFIHPEIQNITFTYKCNKHHMFHISLFHIVHNLWCPNDYCLFECRNKNVKNYSTEFFRLKELDTMEKQKNIFLRAKIYCLFNSYGAIPDTNKNEQSSYSSDVDRIIRNANNPWEVLQVLLHILTICYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHC0</accession>
    <name>V7PHC0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">threonine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_04538</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHC0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000031">
        <property type="entry name" value="Threonine-tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="355"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB57713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="780" mass="90597" checksum="64D74CBCDE635342" modified="2014-02-19" version="1">MSTLNFDNNNLEIQKKNFVIQEDPDFIQYRLNKYNELKEKKKKILEKVIENDPNYYKEINIELLDGSIKTGQKNITTPYQIASQISKKLSENSIVAEIIYLDNVNLNLCDIEDDENDETHVDQSQEGILWDMNVPLIGNCKIKFLGIETPQGKKIFWHSSAHILGSSLEKLYGGYLTIGPALNEGFYYDIYLGNNSIISENYNKIENEYNKLVKENVEFEKMICTKEEVLELFKYNPFKIELIKSKIKNDNEKTSVYKCGNFIDLCLGPHIKNTGKVKAFKVLKNSSAYWLGNKNNDSLQRVYGISFQKKTELTDYIKFIEEAKKRDHRNVGKNLNLFFFEKETSPGSGFWFSHGAKIYNKLIEFMRKEYRIRKYDEVITPNIFSCDLWKTSGHYQNYKNCMFIFNIENKEWGMKPMNCPGHCLIFKQLNASYKSLPIRLADFGVLHRNEITGSLSGLTRVRRFQQDDAHIFCSLDHIKTEVVNVLQFIFFVYNLFGFKYDLYLSTRPPKYIGDIETWDFAEKSLKEALELANVKWKLNEGDGAFYGPKIDIVLRDSLNRSHQCGTVQLDFQLPIRFNLQYKNKEYGVGQETDSNLVNNSNTDVIEKKEDSTLENIDNNQDPINNQPGGVLKKGFDRPIIIHRAILGSVERFVAILVEHTSGKFPFWLSPRQAIVLPISDKFNEYAKYIHTVLTNNLFDVDVDISVNTLNKKIREAQLKQYNFILVVGEKEISTNTVTVRDRDNPNDQKVYTVQELVNTFKKMLDINSVKLNEITPFIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHC1</accession>
    <name>V7PHC1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHC1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="778"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="819"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB58839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1267" mass="150575" checksum="912FB9EBAE940864" modified="2014-02-19" version="1">MANQINGIFSKLADMTIGLFRFQMDNINEEIDENMSPLEKAMLYGNSNLKCRKILFIKDIIKLLNNIDYTDFQRDIYPLIVKLSDESSEIKYEICNKIGDLCAYILQNNNDGCSDVISLLFPIVEKFIINYENNKNILRYILKSLLILSTHVNIKTRKKQIFPFLIYLICNDAYKQIGFILLIKMCYIFDRDNIVIYKVLIPFIEKHCISNNIECKILISSYFFNICKMLDESNFIKNQIFIFNKLCNDEYDTIKIINIFNCTHLSSIYSKNLFFNFFLPIFNNFLKNNNLYVFYYSLINLLLFLCIFEDINIIHPFYIRKIIFFFNNLFSSHLFTLNYLNEMAKKKTNYIFLDNTDGVYDDSNSAKIWNKDEKRDDTPSYPLNETDMVTDFQNSKSEKNNEHTIQNTISNELKYYDNYLNEDMCKEKQNNLVEIIEKDPTRQICNDEQNLTTGCNIISPINGKGLWVEDNKNPHKNSPMQELPQNKSDKNINNESDERDKLGIGNISCEIESTEESKNCNFSSESEILNKRKMEKVLFSSEISELECSSVQSLSNEIIYDENVCIFINNKLINDLIIKNHHFCSNISQFFKTHGNDYYKNGNCDKYFGRKIINLMEKNSDDLILENKINGETIESEEFEKDEENYFINLNEKDIKYIDNIFNHDDNIDILQIKGCYYSELEIIKNDIIYGKMLLRQKRNMYKINNNNKCDSSDNITYDIDYEDIYAIEGVDTDSLKKLFLFDTPNNVIVSYNINAVYIITLHIPGLILILKEYFFRFFSHVFFFICTYPYYFVRKTIASLFYDILSNLMESPFFKINTDKLYEDRINMKKQKKNLKKNKKIEETAKKKLKEECSDDIKKKENNYDGEDSTEQSNLYTYKENNIKHQDINHIYKKEPPEIVQTFNNDYATYNNMKRIQNNSFLTSDKSCENTEDFINSCIMEKHEDVLEKEENKLCDDTLDMIYSNNSNTNGSHYSLDQDDTKNITTDTIDQIKEDKNDIQLKRVKKNAQGYRKKWSYDKMIKKVQNKINNNLYANDFFINEENENFFFYINFLGKYEMIYIKYIQKFKKYYSDNSPLHFFHFFIYYFLNDSNVLVKKAILKNYDKIIEFFPNNIQKIFIKYLSDVVNFKTLNYSLRKKVSKIVFKILSKINDAKIVRNCLFPIFMRLCKDEAAIIRTYTSNYFYLFIEKGCPRIYNFFKNGGEILPLEDYKKDIILTNLENDELRSFHFISGEEIYILKTVITTFYKSDRFYDRQVFIKICDGIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHC8</accession>
    <name>V7PHC8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHC8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="1">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="463" mass="54818" checksum="FBBC9027943292CF" modified="2014-02-19" version="1">MINKAIKKLVSKNFLCFTSRQKQNKIINHNKNIISINVSGIRNVSNIRNVSNVGSGLFDGIPNEEIDKDKLIYLVKNMQMVNLKEKGILNNISNLLKRHMNQFTIDEIYLIIHSFSKLDFRKYSLYNNFVKIIMTKKPVINTRTLTQMLIDLHKTSSLDLNALTFFTQYYINNLVKNFSLFDLSMILYIFNKYNYNDFITVNKICQTISDHFIPIIDEDKGVLTTILLSLSVLNLNYEIYSNFLKLYVYTNYEKFEIKYLCNISYSIALWLARGSVKDKFLSELLKDIVFLLINNMQKLKNDELKQLHIVLYFLRAIEENYEDTIKKIEKKNIKNTITVSKMQHQVEKIFTEIGLNVNKEFPVGPYVLDFALKKKKIYVEVNGFTHYYTFDGKINNKTNLKYFILNKLKWKVIVSTFFLKKKYLKEDKVFFEICTQRYFIILFCTQIVTIEYMDWKNKSKDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHD2</accession>
    <name>V7PHD2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 H</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">(E3-independent) E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">YYC_03616</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with MAEA and WDR26, components of the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHD2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000078">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 H isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="14">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETB58849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="173" mass="19451" checksum="EFDEA7A127ADD63D" modified="2014-02-19" version="1">MAGYDLELNNGSTQDFDVMFHGPNGTAYEGGIWKVHVTLPDDYPFASPSIGFINKLLHPNVDEASGSVCLDVINQTWTPLYSLVNVFEVFLPQLLTYPNPSDPLNSDAASLLMKDKNIYEEKVKEYVKLYASKDLWEQQKKDKNPSKMNGNISPVSELSYADQEIQDIDLDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHD3</accession>
    <name>V7PHD3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHD3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="311" mass="36990" checksum="0FDC6F0B0B0D4498" modified="2014-02-19" version="1">MDLKSAGNVWDALNDLYKNDKQLYDKFMKKHLNEINDSKPIKPKYCFCICTNVEKVSIKTSINEYKEKVCDYFIYIYHTKKIKSPILSTDFIENVNNLNFDNIYISTSKVKGESSKDMYAEAVIHTNIYKNMNNINFKNKIITRILEIIYNSERAIRNDIVINTNSFHFIDLNYIPKTTHYLNTKYFDNDMLNEQPHTNIDETDIKFLNILNEKNKKNNNKEQEKEKDQILIHDSSNDILKDIHPIKTVKNTQINKVDKTKIPKEVKSYQYTIIDRYLPLFVSILTFINFHFSLYSNTEIYYIKKELKISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHD5</accession>
    <name>V7PHD5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_04028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHD5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000584">
        <property type="entry name" value="NIMA related kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB58425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="232" mass="27220" checksum="78D5F2A79708F98E" modified="2014-02-19" version="1">MKHCKGGDLYHYIQNKKKQNTPIKEKRILIWLTQILTALKFLHSNHILHRDMKSLNILIDSDKRVRLCDFGISKVLENTLDYANTLIGTPYYLSPELCKDKKYSWPSDVWAIGCLIYELATFRTPFHSTKGIQQLCYNIRYAPIPDLPNIYSKELNNIYKSMLIREPNYRVTVQQLLVSDIVQRQLKLLIEEKIREKQSMKKPLKEKQTIENDNLGANEQEVKTLLLDIVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHE5</accession>
    <name>V7PHE5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_04558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057496">
        <property type="entry name" value="FAN-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25400">
        <property type="entry name" value="PH_FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="3">
        <location>
            <begin position="310"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="417"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB57738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1395" mass="163780" checksum="3BF00AF4833E3511" modified="2014-02-19" version="1">MEKNKSRCFNLLFLEEDEEYIDDMLIIMKKIEGNNTIENKGRLRLCSKSLIFEPYNNNEDVLKFPFKKLENIKLYEIQNEIIIRASEIVKIKTTIHGKKTRCTSQFIYDRKNRKPIGIINNYYNDYTNEIKNIDNYNIDEYISIFEKILNNFDQAENNSVTALPNSQDAKGVTGKAGINNNEKNEDNKVGHNDDNNLANAFVCSFRCDGTNLMNKKIKLIYSIAVKIKIGIIIHEKQMEILVSEKKNRHKYLNETGNENDVNNSEFFDGLNGNEEVKRKEINLELYIQNIIDKLFENTKFDISSINIHENIISNKIEGFWVFKISPLVKMKGLLNITNKYIYFQAHPNFTNKKEKKWEIEKIVHVFKRIITMKPNSLEIIFNHPNKKYKSLYIEFVDYNEREIMLNVLKKIKPESLFINDNPEFLNLVMNKWSNGLITNYEYIDFLNCLSGRSRKDFSQYPVFPWIISDYYSKEINLNNEKIYRNLSKPVGCLNQNRLDSLIDKMHDHEYFFGSHYSTLAYVVYFLIRIYPECQLKLQSGKFDTISRMFVSIETTFNTALHANSSFIELIPEFYENNDNFLKNNLNIQANETILEDVILPNWCKNANEFLIIMKNAMESNYVNQNIHEWINLIFGYKQKGQVAKDNINLFHPLTYMHTILYEKLSIDRDMRYQNGSHKTPSGYEKFKYNITALPKQLLTSQSQTESYNNVEKNFKDKIKSLIISMSSKALRTQLHEFGQCPYQLFKENHVQKKSNISFELNKNINNFPWYYSPVIIELLEDAYYQKSKNVSKLGSVNRSRRKCTEIYNSNRESCESCENGENGENGENDENDENDENDENDEHCEKNNYHFKTHMWKLEKVDHIPCDIKGVCSNNNNNICFICDNGFVKIIDCYDLLNFKNKNNKNLISLKLCDENFSSLTNINSNFILGTINGNIIFVDTQNVVKRVNNNNNNNRYGAMQNKARVLNKSKNCDLKKLSKNEEYDSYDTNSICSSFDSVFDYKYCTDTDEDNQKNIIKIEKNGNFYNKLIKKKIHNDTIRCMSYNNSYLATGSNDETIQLINVETNFEIVQTYDNINSSIKDIELKNKLLYTRSDKIQLFDIRMPPKNVLNNSNQILNHFTNTINTSRQNYINNIINEINIGNYFSNSSQFSNLSQFSNLSQFSNLSQFSNLSQFSNNCATPPINTFEKENQKYNVHIKKKMKNLIFNNCHINEKNEVDNINRTYTHFQYLFEKKIKKNINSIFLNRPCNIVYSSLINDNNILFIDENKSLYFYDIRAEKWINRFSNTINNNSKQIYNDKIVTASSYKNYLCTVDSMGKFLFEPIRFSINFLDNDVTSKLNNTCSIFNPTYINFFNLGFNSFPDLENTNMLDDISICSHIMFTNLKGDIEIHKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIA0</accession>
    <name>V7PIA0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2007" mass="237504" checksum="349BED6C71A1CE43" modified="2014-02-19" version="1">MINPYDFIDKKLAKKTSTDIKFSNPFNMNIDNCDMDNINVEMTIDEDEKYDIDNLKNCFILFYILYNNFLYFEIIRLCIFFGFCNYDENRKEYFLIIDDSLKCSEIGYYGKVIIIIIFCTCIKFMNYFFVLFKNNKKKWILKDILLLYQKIEKFNKVDNILLLFFLVLFYKRFLNNSNPSLIYNYKNGLYNGNIHIFQYILIIIPFFIYILIMYLYVYEFNDSVCGKCENSYDSEKLNSEKLNVKDKRKQYKNIKCISNNLYSCNNLTIDNVEIDKNEKGSGKNNYTFNGIISEDKKEPKNNSKAINNNWNKTDKLSSNNDIGMVKIKIFISKLIQKVKNPTMNKIESNDKKIDQFLFSFSFFLYGTILLSYYLFLSYVHINKFGGILTIIVIACNVAIYFFLFSKFIIYFKDDIKKKCERTLNIIIKKIKRLGLFGIGNSRKNRDVDIFKDVKKNDNSLKEKKTKMEEDLVLNKEDKNKNKNKKSINNIIKKNLGYNYNKPNFKGINSFVENNYKNIKHKAKRYKLLNISKTWIYFLYNIIDLSNEPEICLAMLICLTLQNEFLNMNLDRCLEVLENNNFCKITNLKIVLKNFIKYRNKFLKILSENSNMSIRFNNCEVDTKSDEIKSNNNVNNNNNANNNIICEDYESLIVFAWGMSILCYCNLKDINYNLSNILLYVSNVLNTCRYFKNIIDICFGDYYNYDFSHNNKDSIENNVKCNLYSYNNLDFNNDYNYINHNSNLNIMDKANNNVQIYSKDFQEPFYNDMGKSVYSENEETKFNKNNRMLTSVGKCDVIDYTTKGEYNNKGSFSGLLIKGNMKNMEHSFVRNQNKQVNKQNEVTKKKWLVDIYNMYISEVCRIYIHCLLVDIGELYFNIHYNYTCEKYICNNLLNLWGYNISNNLYMKRYFENIEKFNKNNMMDILLYNKDINLNIDGNFVLNISDYINKNVINIDFYNIFKKIGKSHRIQIKKLIKEGDYLNYNSLVEFSKIYTDYEEIEQIQNIEVDNKIKNDFFKVFSNAFPLFIEKDNYKYLDMNEINKIEEKKKFIILYKTMGEKYIEEYILKNYEGSKINYFQMDNYGAVISICGSFLKNLLKIEENQFGKMENNTDEGILKNETVKREKYIVNNNTTENDMLNKIHLNMINKNEYNYTNCEFLENKKIGIFSHNNYECKEGVTGDLKGIDLRNGNSLIGIFPSVVLPNAFTIELWLYFNSKNKNNNNNLKSFIVCDKNGNSIFVIDRKNDKIESIGIFSNEINFLSENYKRRYYICNENKKCGKKEKKNVVVNKKVYNGIYIQSEKLKKWEKINKILKINKWNLLNVTKCATGLVYYINGKYLSNISHEILNLEKSFEICIFGNSCFGNNNIGLFSSFKIFEFLNNEEIKKRYKLIKSVKNKEMIGDNINMEKNNNVIEGIDIKMNYMKGNEEEYFIYFIQSPKNKYKVVPTINNPKYGIKIYQLKFVIIKNECNKMEENIDKENRHMKSHFKIINIDNMNEYGFDFYYKKIGKKLDGVPKIYGINIFSDYLIFGCDLSQFYTIVLYPSLCIYNELVKPCGYTISGWFFFPVEKNISFLSLISGTNDVHICVFSDDMILGSIENYVRSNKNNERYTVYHSSGLSIKDIKKGWYYLSVVGTLNGQFYFINGCFKGYHKFCSFDNIKYIGNSSLFINPFPYICFIKVIGRVLSVNEILHEYSISSGYNNFTYLYYYYYLFLLFSNNEENDDGSFVSKNSLIDRSHTRADVISSDDTNSLYCYNKEKYIYFYITKNYNVYIYPLEESKNYYFTLSLVSMINKKLYIFNSINDQINNLNIYFINYIVLPEQWTIFALINIPHINESNYHCLVGGINGRSHIVIDNDNMVLGVLENAEVFKNEEAFKNKNIYEQNEKYNNDIKGGDDDNFTQIRYKEAYQKFYSCGYKFENPLNKDILLITRCINNQQTFFINNTNVGTCRSCRSAITCFGNCLSTNNEYSAPFGNYKFIKIVFGYINDDKIKEFYTNYSLYRNKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJG0</accession>
    <name>V7PJG0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJG0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="500" mass="58604" checksum="C782DB6B26D15B1E" modified="2014-02-19" version="1">MIFMGLNSDYNARINLKLKFIVKSIIKVLTKHLILISILNLIISLCHNYAIDRDSNNQLNIVAHLLRGTFVSSVPSCITLSLLIFFKEHSLNNYMYKEWNFLNIICVILTFYSIFYTKTVFSKDYGNNIYDVLYVASISYILQKRFNTKKMGIHDFQHCINSETKNIIDLIQKGVILNIIPLIFSYVLSFIIDILLTIINSISFNIILSILTHPFDVILNLPSIYNLSNIYVLSSFSYCLSILSAIWISAILEYHFIIFNFLFNKYDYKVLTSLNKFPMHNQCSYHDEFFVVTCIYNYLKDVSYRIKGHNIEITNMDKKTKLKLLLFKKLILINASLKYKDEINILSHICNPINTILFEDNKFWNTYIDSCILCIEDLICQLKRYINILNHNQTVYSIEEKLELKNIMDKHRINKLKDTIVLTCIYLKGVSLWSIAIIIICKNVIVSVIRKLSSIIVSLSYVLFDFLNFIKINELYDPLHHLLYGKPKFYISKQTNVFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJG2</accession>
    <name>V7PJG2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJG2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="156" mass="18907" checksum="0B61DB860CA3944A" modified="2014-02-19" version="1">METKKKQVLPSPKNNKKQNLNKNDVKSTIEAFFKEQEQIYKAEESLTIKCLETEIRDKEKELNEYYTYCQNYKQTYKNNFNNIVKQTEEIKKELKDMHIEYIDSKILLENKRKIELESMLNFYKDKLLDIKNQWENKTFCDENIKNIVYDILGVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJG6</accession>
    <name>V7PJG6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJG6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="338" mass="40351" checksum="9D90EF3885F71350" modified="2014-02-19" version="1">MKKQLKIRKTINTNCISLNKLLHNGIENSQIYFFYGNNAKMNKIILINLLYNFIYPFGNNNMSTHSVVYIYFSYIFDVTVIKNIISEKLNHEKKNPKQKSDFFNNFYILRIQNFNEIISFLLQLKKNYFTKNKSENDNRLNNITCIGISIIIFDYVQNEISDTSRGTNIYDNKKEEPQEINNTLTYNEDKIYKNINIDNEPYNKNTNYVSRKNKQYATTLQKNINNNQDYYSEQSSDLSSYNYYENEDQKYSEYELGNNIKIDDNNNNNIKDIEKSEPIKIPFSCSKHNKFDFIIEIKIVNKIRDRYIIRFTILKSRNNIKHSYSYCSIQKYVLTDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJI0</accession>
    <name>V7PJI0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJI0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="1">
        <location>
            <begin position="377"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="441" mass="52140" checksum="EF18D605F6162BE5" modified="2014-02-19" version="1">MINKAIKKLVSKNFLCFTSRQKQNKIINHNKNIISINVSGIRNVSNIRNVSNVGSGLFDGIPNEEIDKDKLIYLVKNMQMVNLKEKGILNNISNLLKRHMNQFTIDEIYLIIHSFSKLDFRKYSLYNNFVKIIMTKKPVINTRTLTQMLIDLHKTSSLDLNALTFFTQYYINNLVKNFSLFDLSMILYIFNKYNYNDFITVNKICQTISDHFIPIIDEDKGVLTTILLSLSVLNLNYEIYSNFLKLYVYTNYEKFEIKYLCNISYSIALWLARGSVKDKFLSELLKDIVFLLINNMQKLKNDELKQLHIVLYFLRAIEENYEDTIKKIEKKNIKNTITVSKMQHQVEKIFTEIGLNVNKEFPVGPYVLDFALKKKKIYVEVNGFTHYYTFDGKINNKTNLKYFILNKLKWKIVTIEYMDWKNKSKDDKIKYIETNILEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKE5</accession>
    <name>V7PKE5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKE5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="31149" checksum="D49A88D76B739EBA" modified="2014-02-19" version="1">MIDSNYDRINKINIMNMQNGNDIIKGLCFYIDNIKICDLLKKNIKNVRKANPIVERKNKLNLKKKTIDPEKKSDSIKKNPCNIKSLRIFNTNIDINAIILLSKILYDNNYSKLEHLAIDCINLENDSLKYMSLSLCNYNSLKSLSLQYCNLNNDAIKYIIDIVIYVNSSITTLNLSGNKFTEEGICSLFESFLLNNVLSNIDISYNMFNLSSPFIEMLSKIIINKTVEKKKIMIFLGKCSLLAIYDYVYMHNNVELRKYNIKHIVINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLH1</accession>
    <name>V7PLH1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLH1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42509">
        <property type="entry name" value="DIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42509:SF1">
        <property type="entry name" value="DIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="2">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="169" mass="19494" checksum="C4E8B3CC1891947E" modified="2014-02-19" version="1">MQNTTIVFYNIINDKEDKNSQNVFYISKPPNLITLKDISDGFPLPGTYHFRFKINHNNNTVWVDITDSSSNIPTFNSSICMKVLRLSWLNNKNDKGSLNDKIANDHNLTPSCENDKIIFEEKKININDSTNLNKSKPNIDMLLFETTPNKTTHGNLRDKKGTRKCQRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLH2</accession>
    <name>V7PLH2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-activated potassium channel BK alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">YYC_03200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1240"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1241"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETB59815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1654" mass="197959" checksum="9720E72F7D0B97F9" modified="2014-02-19" version="1">MMPNARLILERIIFIVIYIGTIYTFWNYMNIYNASIRYYSFLALIVIYTTSYILAILPEIINSIKDELFYKTRKNKIYSHSLRKDEVSKKRKKKDNNKGLEFSNSIDTNLLYIHQGNIKYEYINRDNNLRIHNTWNDIEENEIKNLEEGNYSSEYDRDDEERKKEKNIYHGEINGNKLHEEENQTMDAGKVDYHATNGEHNINDEINDYILKKKEKNKKYIIDSINDIEDIFNDDQTKTLKMKDQMIQFIELNCMDSELEEANDNADENTDENVDENGNNHKTSKKDFYKMGSIKKMNNMIISNNMSNNEDQMIYNKKCQLNDLNSYIHMSLKDIKRANESFLYDVKYLNTKTLDFLTDNRELSLMWKADSMRAKRKQKKRKYIYFMFKSRNDSILGLSNSYFSWFKPNGDKYVLDSFYERNKQVQKVKPFSRWHNLLLKIIINIKVTYLNFCKNSSFLISDLIVTITLLLTWIGAYNYFRRNDPLTDRGMFNWNTDYLPNLYITIEGYLQSIILYDICVKLILFFISHHMFSFWFVLNMLNTPFLYILISKFTMVKYERYGWLYLTGPFRFINILRIENLFVENTNRYNKLNLPIITLSMHIIILIYTYACIHLLIEQPCKGDYQLYDYIFSVMQTLTTAALGRGTCFPFSLESKIVHTFYICMVFTYLHYKIRYLKNHLVEDKQIYGKIPSIGSRYFVIIGHIKPIALYVIINELQSTYNNIDDIIILTSLPVRFYLNIIKLLNKKGLIQISLCRYDLNKPFPLTIKKIISYSIGIFICNNIMNTYHNINNDIETLKRYNEIKSLGPFNKYTSVLLNNMCNYNILLKKNYRNIICLNDLKMKLFAKTMDDCPGMFLLILLLFINVPQKNQSKSTDLLKKYFDEINLNNDSENEKKYRKKKLYRWKNNTNDKLKRFHTSLGNNHNQEKEINIFENKKNNNYNIEIIEDGTNHNYEKIKDVDLKVIDENTQRKANKISESIKKEKYIFNLFSKFNKNKKRMSLFPYMRKNIKKKFYNSTNEYSYHYNSYNNYLDYIKGIKYNIYKIKLPTLFFNLYFTTIAHYMYMNYNVFVIGIINEYSEIKLNPIDYIYKNEDVHFILLTDKYNILQKIKNIKNIEFDWNNNIESIKIKINKQKDAKKNLDNNITNKFIDKNCNNYYNNIKKLKCDISRKYFDPVLNIFRVDNYLQALEIFKLREKQDNHMRASSNDSCCSDVDNKMKKNKNGIKNVSNKFESYENGEKNVSLSSMTDSETDNIKSKNDKPKKKTCKKHTPNFMILINWAQSLNTFLKVLYKRKKHNIIILSDNVPAYIYNNNLSKYNICYIQKSPLIMFNLIIAGILVCKKCVIFKNYLKLNSYENIISHNEKIGLNYFEYMCKTNDNDTIIIFNNIQNIFRRRDKKDAYIDFFINENNNFNAYNDYFKKKMSMKNDGNTYEDEERKKLLKKIKKNDNKNERKNNIYLLIELNNTLCIQYLNNDPYTTINVVKNKLHHLNMDIAHNLLFIENYKRQIQFFKYGNLLVENVYKKIEHIFIDNYYFYLYFLQFTSSNVFVDELIYHLIGYTFPINNNSIDISIIESFIHGTYSDENKQFKANLLLKKIKLKYHGVEFFCIFQKYLKKGAIIIGVYRLNEDNDMSVVIPCPERNFIMHKNDRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLJ6</accession>
    <name>V7PLJ6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLJ6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1215" mass="145335" checksum="D4A49D6800F22ACC" modified="2014-02-19" version="1">MFLLQNYFKLIYSIKSLSIYKIGIFSILFNSLFLNKYNQYFSISNDLFGMLFTNYFFYEGINNLTKKKIENFMDKYNCTKEDIFNSLNDLFSQFLNKQIYIEKEMDEKIIYNISSFIKLYKKLFINNIDNIKNITFLVLNKYNVYYTSVENINKTNSEILSRICYIFYIINILLKYNISSLQNFNLINNNEYNIPMFKSNNKLSNYFLLTSIKDHLMINENVINDCILDRMKKNYEKHIYSLIENKNLSTNIFDDIKKLEFLILDKSLINEVNLSIFNKLVNGILEKKNYDTPYFKHNQLASKENGDFSNVKSNIIEDTSSTGQLMGNNEINGDEQYLNNNVIKDDQNSKDDDDDIEKYYSENTNYEEEETEDIEGTDAEIYDDNENIDERMYKYIEDSVDYIVEGNVKKDEQNQETKSSNGKDNNNKSDEGEKKELETMLKKIKDIHSFRKYLSIPKEFVDNQLEKYLFPYMNKEYKIFLNNLIFKNFKNKNENLFFLKNGITLSSECTENIIKNIILDFVIKTKENINIFFKLDNMDKCLKLVLNLFYVYKKLKKKRKYIKTKNMILNLENIFSHNSFKGQTFGKQTISSETTKETTVTDYTDDTSILNKINDTKKNNVNENIEKEDYIDSDISFPNKKEEFLCNENFERNMREEEEGEEILSIDERKRLYEIFVLKYMKNKSERNIFKKVFKLDNVEIDKEVEDNIIKNFLEKVVKSNLENLKKLNSDLGIINNENLFDYKNLNFIDKLEKVKKNNKHDSNVNINKYIIKKDDIFEYIDDESFEEISKKMYINKLLLLKDNLYNNRKDLYLYEIILNINNSEGIHDIYLIDQYEKMINDIIKTNLLNKNYTNIKNMYLKKIINFLNISEQKATDVELRCIYDHIYSIFLSIKENFYIYKTDSDFFNNINEILTIYNNYDLIKKNGEGYLLKFALIETNHNLLQKLIERYVLYVIDIINNENKLTYKENIFKLAKILNVNNTIISDIGAKIYKKYIENQELHAMNNMDVFFNFLFNMDKGKQGEIILDYLRQKVQNHLNSNESYQEKLQKLYDLLNFINNNLKLNKNMFDFYHQNGEIIYEFLISCIEDYLDRKKSTTFISSQSDYMMHFNNFLSKIKMLIKGPEEKSHFTHVLNILKKSIIKKAISFMENFKYDLCVEKLYNFIKLQMIDNTFVLSDIDIEQRKKMINIFSYQNIDDEKKHLYMDILNKALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLK0</accession>
    <name>V7PLK0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="14"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1109"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1126"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB59657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1349" mass="161489" checksum="A8DD0D403530C457" modified="2014-02-19" version="1">MELFKVEDVNCQLNYEITLGCSYNEYMFVCTIDGYIYRYKIFQNKEKNNNIELTYVDSCLIKKDKKINKIIIVECDNTFILLILIDDHIYFIKNSNFPNYKIISKNIDLFTINESRRFELLLYGQKKKKLYFYKYVDNNYKLYKDIQFLDILTSFLWINNSLFLAINKNYYLQNLSNNNDNNRVLLYSHEFEQTYKYITLINLCEIFIVCDLNIGVFYDVETSMPSRKNTIILPSNIIQLLSFRFFLCCLNSRGVLNFYNTNNQQHIQTIEINSGIKDGIENGIKSGIKGEIKGGIKGEVKLVVNFSSIGGRNMFGELFNFENSYENRYENRYENRYENSYDGIRQEKKSPKKMLNFKQAFSESVITNVKGNTKQYGLNILDNKDIEYNNDEEKMEMVKLLSISDENNYLKNSLYIINNNFINVIKCIELYKYLPKCIEQNKIETGFLLIENNNFENEIDKINILNEYNKACAYFYFKKLNFSLAFMLFEKVNINIFFLLSFWANYFNSSFKKSDNEQDIYLYSKNKINDIKNIEENINKQFKQFIPIISTIYELIEQEYHLYSQNVTKSYMDTHNNENDNNFLSKKKILNIANICLIKYLLKKRDFFIENKYDIKIDRAIWQNIAATPNHRESPTHPMPTHPMPTQPIPNQSLPNQSLPPHHLSYKYIHIDELIDNILIKLMVSSNYKNLSPFIMKTSNLNLDVNECIEYLKENQKFIEIILINIRFHNFDVAIKMCISFLHYYKMVEDSDSLQHEHSNMECEKNGDDQDMWWCKMLDEKNFKNNIERSKAFHSILKEIYNVLIILNNNVHLINIEKSGIKKLFECSFPFLLKYNEKLFYDFIINNNLILRPHEILLTFKKLQDIKLKKKINYYIQKYVMNYIKYDKKNKNVNAILLELYINDSEKPVQVRQKKILKMLRSNYPIDTNHIIQMIENKNFNLVTALLYGRIHKHYESLEILCEEDLGMCEKYCHYYSFMLKNFVKGLKKEKYESIFSSIYNNDKTIYQKLVNEKNPNNDLSTNDEYKQDDKIVKEKKNNKKKADKISDLFIKDIIKEYHKYSYITMNKNSLEKIKKLNNLNKINDENIQNKEENIKKEYDYMLHLIGNEKNSSNDDDTTNYYDNNPSYGYSSQNSETNKSTNYQHFTDIENENTSDNLIIDYSDENNNIKEQEFAKKKKKKNEREREISIMGKKSQNSKLKKKNDKYKKLLGNISKNRDIDLLEYFHVYNENKCRSCGFFFLFIKVCMDKYKNKNTCETKKEIYKNYIIYILNKYANHNDLNNIYIFKMIPENWKISKISDYLNFYLRKKLNTRTNLEIYHNLIKSTYLNTTYNMIKRKEEKIIIQDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLK5</accession>
    <name>V7PLK5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">YYC_02618</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLK5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054606">
        <property type="entry name" value="NDH2_hel_ins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22365">
        <property type="entry name" value="PfNDH2_hel_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="38"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone reductase helical insertion" evidence="11">
        <location>
            <begin position="393"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="12">
        <location>
            <begin position="497"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETB60309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="560" mass="63770" checksum="C8B3F9B44A95A1C0" modified="2014-02-19" version="1">MILSVKNSKIKGIYRSVSNFCNLNKIKNVNYINKKREKVVILGSGWGGIHFLLNIDFQKYDVTLISPRNYFTFTPLLPCLCSGTLNVDACSENIETLLKKNKISGKYLKLECTDIVYKDKYIKCKDNVNNNEIKINYDYLVISVGAKTNSFNIKGVDKYAFYIKDIIDALKIRTKFISNLEACIKGIKTGAVTNTITNDSSSSIGDSSSSIGDSSSSISDDLAKKMLHIVVVGGGPTGVEVAAELADFVNKDIKNKYKEIYKYISISIIEGGNNLLPTFTQNISKFTEKIFKNKLNINVYTNYHVIEIDENNFYIKSSINKNEEHKKIPYGIIIWASGLAQTSLINNFIKKIPEQENNKNLKVNQYLQIIGIKPNNIYAIGDCKQISPINSHEHVNEIINCLGNSKISSDVLKQKSKELSNIFPQLSDTKWDYNKNKKSEMSIKELEEYLFMVDKNYKSPPPTAQNAKQEAFYLSNIFNNYLYNSNGNTIPPFIEKWKGSLAYVGNHQVVAHLPFYEIKGGPFSFTFWKIVYMQMLLTWKSRINFIFSFLRTKIYGRPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLL5</accession>
    <name>V7PLL5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLL5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="972"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="713"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="849"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1069" mass="125204" checksum="BA2DF63929542AAD" modified="2014-02-19" version="1">MEKEILLSLAHNANAQIKNEISELNDEIFFLNTKLNINKNNKLSNIVKTRCNKRKEKKSEELNNFFFKYVMFLLSNKSNDNIEDIEETHFYNMIQKSGEKSGEKSVEKSGDKSGDKSGDEHFLKCMYEKKDELEQILDLIKLNDLENLSNKKSEEIFSNLMLKFKNMENIVENENILNCGGIDKETNELNVSENMIQKLLEYLMENISDTKFKTCDLSTAPSTVSLVETSEKESDFEEFIKYDNNNIQKKISEMYKNGNKNGNIRNSVYYNKKSPSFGSIFLKKDSQNILLNKFNASRKSFSESRQNTNKSLSTNEVLIRKKEKKEKEKKKEKEKKEKKKNDRGGSTHRVNVKLPSLKKQTKKGIINKIGDNKIGDNKIDDNKNLIQINKCENNKNCNNKEKLSLLNKNSPIKSENKNNKNKKMKEDNISLSDSALSDSSLSDSNSIHNLSENEKNEKNVGLKKLCLKINKEGKGKFIVNKKKGINCSKYIYDFEIVYENSETSKLNECEESTNPKGGDKNGGRGKHIFHLSFLTNGKKVYQVNNLDIENYNIINNLKNINNRQNRKINTSVYQNNKIKERNEKESSESLNSSNKEDEYKNDLSELDVKDVGKINICNKYESKKIEKKYRQRKKLNLKKKENNFEFKETNKIRGLYIHMLDRQNQLEIEKDFYKNEFEKLQEDVKNNTAPINEYLKEEKLKHFEREKLFYKKEKQFIKKKNLLKKKMLELENQLEIAEKKLIMEKEKNEDLFLKIQDEKKEIEKRESVNESKIKNLNSELEKLNKSILLEQKEKDGLLNELNILKNEDIEFGNFRKNILDKINKTNGDIKYLAEILELLTKELEKKNILQNLNQKKIKELEENSQKTENVLRITKDKLLLEKKKKKNLFKEITHLNRKNKDLGKCIKDLMFRQNSEINFKENTMHLTSLSSDYERNKNKKSTLLYDSTSKTNLTINSDSYNNMLHYKIKYNCNSNNDDNDDNNDNNMKKKRKKKKKNSEIGLINNTKREYYPPSDKNDTTISGDSSLFLFNQNSKSKISFNNLIESMDDLSGDSTPVLKHNIVCNFKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLM2</accession>
    <name>V7PLM2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLM2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15773" checksum="9D1B7B74B6AFCC38" modified="2014-02-19" version="1">MDKLKYNVSGMGTTFLTIKNVLFIIMIALFIIVVYKYVKYKSKISEAKRNNEIYEKMKISREKQLQKLEEEMIINKKKMNENLKNTDKENNNKTLDSSTPKSNSKDKSTFSHFKDYSNYYKPSIRDRYKGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLM6</accession>
    <name>V7PLM6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLM6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="442" mass="52433" checksum="41B4896F773A7C88" modified="2014-02-19" version="1">MLYIFSSLDYMYKEWNFLNIICVILTFYSIFYTKTVFSKDYGNNIYDVLYVASISYILQKRFNTKKMGIHDFQHCINSETKNIIDLIQKGVILNIIPLIFSYVLSFIIDILLTIINSISFNIILSILTHPFDVILNLPSIYNLSNIYVLSSFSYCLSILSAIWISAILEYHFIIFNFLFNKYDYKVLTSLNKFPMHNQCSYHDEFFVVTCIYNYLKDVSYRIKGHNIEITNMDKKTKLKLLLFKKLILINASLKYKDEINILSHICNPINTILFEDNKFWNTYIDSCILCIEDLICQLKRYINILNHNQTVYSIEEKLELKNIMDKHRINKLKDTIVLTCIYLKGVSLWSIAIIIICKNVIVSVIRKLSSIIVSLSYVLFDFLNFIKINELYDPLHHLLYEMNSIVDIFKFYKEDILDNKYQYSYNLYKGLSYLFRNKSLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLM7</accession>
    <name>V7PLM7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLM7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="280" mass="33441" checksum="18C39AA442FE5236" modified="2014-02-19" version="1">MKILKKFEIFIILVVLFNKNNKFINCNNDEDNKDTNIYISKCDKFPNFLEKNSNIIEGSENLTYEDVQKKIFDIDLNTLHVSLIKNLQISKLKSIIDVKTAIFNCLIKTMAKALPGILEEIFAHNEFCGSIEKTFSFLFEIDETYEFMIKKCFDLTKTAILYNYFYSYIQDIDDVINVYRNDPSKIFSKFDYIIICLNELYRKITENFHPYVKDTTVFSNFISEFKNKKNEKIKDNINYIEEFIKYFRENIHNINVIVFFEEIYGFYSVNNLYVSCFYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMI6</accession>
    <name>V7PMI6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMI6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="409"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="523" mass="62050" checksum="FEECD8616FC181AA" modified="2014-02-19" version="1">MIRVGKILFTAFSLCYVFVKQLKRINLVKKIFENIKIESDLELKVSYTELLWRSFRRIDLTTFNIKSLGINIETLEKLKDFKILKFDEECISWLKEKNYIDKKNIIENGSFSISANKSIVNKDFILCYLGNCSIFLYYDNTEENEKCKIEIPYYHITSIHSKSKKSFTLDCKAIAEHTNIFCLWSEDAKNSIDYETVNKLSLSLKIKKTSKGIKELSTVLDNIILKLKTEENKNEKETFEWKKHKNNKKKYKKNESESEEREAKKRFDRSEVLSNSSIDDNNDIRDVLKNTRILKIETYDHEVEKGKKNEGNYKSKHDKPSNVKSYENKNVLKKIQDHERMLTDYKFDLNTPRVNEKHQNDGDRDSDIEIMIEKIISCKKEKREKFKMDVKKKFSDALNDIDTNIKSLIEKQKCRRDELQKKYEKKKKNIILNTEKEIAILSKEMNVLIENMKKISLNKNDVKKLYEEGKSIFYPSEVMDKSQVLIQRIHEKLEKMNTDIVEKEKEYSKRKKLCFKALATAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMI8</accession>
    <name>V7PMI8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vta1/callose synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_02251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMI8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB60619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="248" mass="29166" checksum="9512B3526A8B675E" modified="2014-02-19" version="1">MEENTEKNAEKNAEKNKKGEKPNMKQIKFILKKSEELEKKHPLASFLCVLYISEKLNDYVKDNYSDIEAKDLLLNCVKKAEGIRPSFDFIDYSKLADLCKQLFLAADKNDRTDEITNKTIHMFFTAQIFYEILNHFQTLNSDEKKKYLYAKYKTIYIKKCFDNNIKPEPGSPKVELEQDPSEKLYDEMPINQEKKKEDIEKEKSDEENKWVKDDILWGGEENYLLFSKNEDSNLLSNNTNNNNNNKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMI9</accession>
    <name>V7PMI9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMI9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="906" mass="109127" checksum="16E90C1B20F3B151" modified="2014-02-19" version="1">MFSFNIYFKKCLGVKSEIKYQKWCRYYNTGEYSSNVSRIFNNINDKLKKKNNKSIEYEKCDKVVIKDIKDIYKQYESVIKKINFSKMMGRDLSYCMNILSKINYFKEHIFWIKCANRLIKGFMIHRINTQSYYIISNALSKGTVLYDKDINIGDEVSKFEEIENGKMEKKIKNIIEGPKFCRINFDGTVKLNKREDKTNLDKKNNSNIKKYHKIYEEISIRFLYDVKRMNIDEISCILNLFSKLNLNEYNLLSYYFSDYFVMSFLKNKINFEKYTNLCYSEINREDVEKKPNICFVEKYDISKLIIILHSLVNSHVTHVEFLYICCYYFNKNFEYLNNIDICNILYSFGKNSDWLLRKKYRKYIFLKRITDKQYVSYIKNIVEGIKEYGQFYNNNNKKDGSENLCYIEKLYFNNEKIDIGNSLCSINKIYEKGEIYYSSLLTKILKHIQKEKVLNKFSCIQISSIVLSLIKLKINSLNIFHSFNYKVIEMWKEFSLRCIADYLYSKYEINLSNDYVLFLLFYKFVQIIFHKYMEEFEKIYPKHDNHINSIKQSKEGIYFFQKNYKKIKILNTRDSLLIVRIFQSFSKGDTKNSLLNDQNFKSCYDYLYCLEYVFMLYKNKENERQLKGSVFIENKFNTNDDDDDNRNNKGEYFWRELESTNNSSIPLLNNFDKKYEAVKRLTFRTLCLSLFQHLDNFSFEYKCLISYFSINISDYFYLVNYEGDEKKLNDHFLFCENSKKKKDSSYYINKNVKMNHCHKEKVPYFEVSRLCRSFSSRMLFHVLNEMKCETLNEVTLRQIYTCILCLYLNIINIWDIAKIKLKNDKKKYLLLLGNVILQEECKSDLKYLNFYKKNINTILMNTNKMPDFTIFHFISLNILKKIAIFLDKAMEKNYQQNEISISSSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNL1</accession>
    <name>V7PNL1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_02657</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNL1"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB60357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27898" checksum="325F721B929FC8DC" modified="2014-02-19" version="1">MNESSKTEDVNNSSRLNKPNKKEKKKRWRKILYEDQEYEDNYVDKDFLSHLLTNFRTEYKYSNIVHRMLCINHQIMIVLFHLLAYYSISNNIISHRFLYTINIIIIILKEVLVYDIHKSLNDSFKNILDTIIIIGIIWILSPVMISLTQTHSDDTVYLVSLCILLPIHFMFHNYGFIYEKNENIDIFDSTSLSCVVVESVILGSRLPSIIQVFSFLFCSSILFFYTPFIVQTIVVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNL2</accession>
    <name>V7PNL2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNL2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="404" mass="47485" checksum="3B4AA1B94B18393F" modified="2014-02-19" version="1">MRYKRNLSYSTEGIHLYNEGYFHGGDAKLENNNISSEFGINIFPEYYDIDNIEYAYDIKNKQVLKNIDTNYGDIQRITNLDSLKTNSYNKNNNNGTKIHDSKILYGFQKEKQSELKPIIEDKKVLSDNKIKLNNKKVNGDISMHKEVKFINKVDDIYNFDEYIKLYPNPDMNRVLNKSTFQRKDGMTILPKIKHDYTDQKNVSIETIPQIVEKRENKKEETNDKLKNIPRSDHGLNKLNTNKKKKEKGIHNKTIISNLNQIKNGFDLINSLTKKRPKNKNKPTANVKILDQKKLKNKAQIAIREKLKEKVKPKEQELKEKIKIQEKKKEKEKGKGKVKKQPFYRVILDKIKKKIESNYIRGIANAFIILIFSYFIVMLLILYFILNAIRPKIYNNTVSHRGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNL9</accession>
    <name>V7PNL9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNL9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="136" mass="16359" checksum="D84A6286A024BF68" modified="2014-02-19" version="1">MKLKLIKIVSCLFFICNIQAYVLNKSLKIFPKSRWTKNRNVNSLFLKINNTINFKNRGELKKEIIAHSKKVSLDLNDEQIKSIENKLNEFFSYMKWTNIRINLGKKKFKHKLKRLSLREKEGINEEVNMEYFIYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNN0</accession>
    <name>V7PNN0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PNN0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB60575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="117" mass="14311" checksum="6495A7F451CD3680" modified="2014-02-19" version="1">MRKIWTPIRRSEDQKIVKNNYNEEEKENFEKSLPKGFIENNRNNRVPYFEIKESTMIEQKEKKEVQKILALELRDKCRPEIDEYVECSVGKLWTILKCKDLMMQMRNCLKKYENFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNP7</accession>
    <name>V7PNP7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1385" mass="166849" checksum="D7DC74C0E3FE962E" modified="2014-02-19" version="1">MTNKENVINCKRLHRENMVFATISNDCNYICIITFYENNYNVELFNANNKMQKIFRKEIPDTINKVYINYNNKYICVTSQNGSIYILNMKGVFLYKNEILHCLFRKKYIKQKPISINSHFNYYYSKRKRKKILRSTVNSQKKDNEVYENKQKKIKYNKLSRKNSVTFSLNNNKNNQQNDKIFTENNIIINDDKNSLSENLQELYNNNNYFFQKDQEKQNFSLKSKTYINKSEKNEGYTNLHFEKKKEDNYYERNVDNNINKFYGMENIKNKKEHEDVNEIIYLDEYLNEKSNTLEKYKDSKKINFNNYVCTEDCKKDKLLTNEDFIFEEPEYFHNELGIDSQNEIKNSDEEYKRIGIEIVDIYWICMEKENKKDLIEIDNCIYSYDNLNKSNFYDNLHIIYSLDAAFNIICSINLKIIIYKYNILNYFYKNISPNNQFKNNIVYLFKKKFLQKCKEEKKYTFIKYLKSKLDIYNNNSCIESDHNKIMNKRKIQDNLNTSINRYKNLTQLYRPSYINRIGQYSSYYLDVKENIIKKIFNDMIIEMNQSYISSNQNYILINYYINIKKKYLKFSSLNIGMLIRKKKNPAKKIINKKEDNKEKKINVKRSRESFSSCGSKNYDEQNDNSMMIDLVKIYMNKNKLAKFPTYKHKLGVLGIQKINTIDREYKSIEHFALYLLYCFDIFQNIFNIYKRMSYIYSRCDEYKKLYTIYEYILSLNENYKKYYYKDRSIIYFSKYIKNRKEYFDENLYKMFFKKSEKQDFDQFYYLIKKMINENTVCCSCSKKKYLEKKKYEQSEIKSIETSQYFKTKPNIKINFNNYQNKDNNINISRPIKNYSSYTQSFISKMNKGQDKIHENIKNIIKINKENRYTNSFANISKYIDEKNVQNNYVYIDADTDTDADAATDADVGRDNRFALNKINKNEKQTTNTVLALNPVDDISSCCFSSGNSTIYESDKSSEEDQSDEIYSSVSEQELEKCFLKNRKFIIKDDKTICEDCENILKNNILLHTFEKFELNYEIPKKKKKIAQKKIYSSLIKDIYTMYREKKCPINILLLLQEINDKELENNLIHLQYILHFFEKTFLQNISDYLNNLFKIINVCKGLVTQYNCHCKKEMNKLYNAALYCRKKFESFYKLKTPLNIYYLVIELLVFISKNIYFENFPHYKKTFSNYRYVDLLNSYNIFKNNKMNFSCLDKYLHINSIKAHKFYIALNQLRISLINILRSFSNNNNNNNNFSILYNLSILNVPPNKFHFITLPKNKEKYHSCNNYSYFDDILYNNQNKLYPFYICTCDTYSFISIKKYIQTNKTFMLIQREFININLYPLRLLNIIVISKNMFYIFTEKDKKLNITSIKVKYDGSQKKILNNGEDMREISNLSGKHLSKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PNQ7</accession>
    <name>V7PNQ7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_01169</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="396"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="841"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="690"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1171"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1214"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="205"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="713"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="757"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="855"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1215"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB61231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1531" mass="177909" checksum="AA35505E4C0FDFE5" modified="2014-02-19" version="1">MEHENCESDSNYINKAENFENTELETDVLSQNKELTRKERKRLEYEERNRKKKEKQIKKIKKIITKCNIKSLDGLKNNALINNKDLSQICENNDQPTSITKTEHTKQKLNNDTDEYAETLNREQNVNNKNNSKSKGQDNISGLCLNNQLQSLGILSKKQIMKTLKNKLKKNKESEKKLLFKKIEQFNLNNKGHTIMTHTNVNNKSEKKQENLDKLFKAYEEMNIDLPNNLKIAKNKLEARKKRLLKCINKKELESIVEQEENNPPKKSKVIKQFNHKERNDQSEGNKTNDLASENSDENLEDDYAEIFKDDSVTRSINFYNGGENVLYQNGNDQKEMQSIEIKEYERIDEGNDDVNEKDKIQERKILYERVNINRNEHIEKLRSSLPVVGYEQEIIEAILNHDVVFISGDTGCGKSTQVPQFAYEYGFSTNNYLIGITEPRKIAVKSISNRLNEELNIKDVAGYQVRFEKSNFLKNSKIKVMTEGILLKEIMSDFVLSKYSIIILDEAHERSINMDLILGFLSIICKIRKEKYFSYKSDIIPLKVIIMSATITDNNLFENKIFTDYTSINIPTDKVPVVDHFLSYTPKNYVEEAKKKIIQIHKKLPPGSILVFLTSQEEIYQLYNSLNKLKMTKEIIENTTFSENSKKHIESDSDENLQIFDLPEEKNTENERISFFVKDQDENKEKTIIFDASDDEDSDSEEDGVNSKVDENENDAENDAENDAENDAENDAENDAENDAENYAENNFESKETSQNEEISFNSSEQISKNQNSSKIPSGNDTNACVYTEKEISSEHNEIETFEKEACSFDENIPPNSHFDSDQKTDGKIENDQNNELSNDADNADDTDQNDQNNNDKKNVKNSYKENNSEKSKKESTIWKGSDGSGKLTVYKLYSNLPIKKQMQLFNNPKDNERVCILSTNIAETSLTLPNIRYVIDSGKEKKKIYSTVNDYSYYVIDNISKSSALQRKGRAGRVLHLLKNNKKNKKKIEMEKGHVYKLYSSNYYNYFFKNNTDVPILNYPLDSLILYLLSFKIENVEKFPFINKPDNSKFQEARKRLIYFNCIYFGYKDVEFLFKNLSDKIASKQGIQNHVNMFNPQNKKGITLVGNFILSSPISIRYAKILTDVCLKSLSIKNTSTIPLACLLVSCLYLESIFSYDYKLSLKYKNSEKKKKKKKTNNSQTNGNDDNNKSANGSISQSNNILMNLILKKNNDQEDQSDDSDSYDYSSHEDNNSSYQNSNNDEKNISMIEEYKSNFSNDIDFYLNLCISFYFSKERDQFCYNMKLDKKKMDELLKLSNHLMKIINFKLNHNITFDMLETNISPVSKKIIYYAIFQGFIDHLAIRSDLIHNEHTRNLQIKNYNNKKAYFTQNMNTPIYINSNSALYKNRPYPHYILYNYIMKNRNSYLMFDCLNISDSDLGKITNVCIYINGYEQIPPPTYNMEKDKIIVCARPIYLPASHYLSIITKELNENDIAFYNYIALFILDGSMFPKMLKFQRFYSHTASNIINCSTQNIKRFIAELKNNKINNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPP3</accession>
    <name>V7PPP3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPP3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00139">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="8">
        <location>
            <begin position="810"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1158" mass="134882" checksum="85D7B131445A1F85" modified="2014-02-19" version="1">MKCGNVNVRNVLEFNLKKNIKEKTKLTDQEIVIIYKRFHSISPNGKLDYKQFEKSLGILGTIKNAYLYKCIFKAFDLNNDGYIDIFEFCVAINIMLKGNKRDKLKLSYRIIQSGSSVKLENLQGEKHSKGDKNLQDEKHLQGEKHSKGDKNLQGEEHSKDDQILKDDKNYLEYINYDDFERIILSIKDIKKQLLGEDDEIVISHVKYTFKSLSILCDDGKDLPENGDEKNGDVKSSNNNTFKKDDIVPSSSEKKLYLNNISTKYNSISQKKQTKDDENELFESGLNNKSGKKILRKIDQIKLDKKINKRCDNIGNDFKKLENQISQNDERTTNIYYDVYKEPEIKNKKNVPNLDLAHIEQEYESKSYMYSTVEKKMNKNGSMNKSGSMNKSGSMNKSGSMNKSGSVDNTEFFDLKLQIFEFEKKEKNKKYIDTWNLYINKYKEYIKRVEEVETGENANGNRDGNASGHGNGCVNGSFSDNLVESNNIEKYYDKCNDIDSIDSDNNSNIYEKDVEGESVESSVSTYTKMSDKINGDIIKLIENQENESNDYISHGSNKKEENSSGTFLFEKYIEYHKFVNETEDIKTLINETYKNSQQLELSSNSQHFLINKNLSKEKLLYHIRIILLNVEDCLKSDKDNENYDKIFLIFFYIFIYNNTHEENTKIESKQVCIRDKHLKKYKSVLLIVSIIRYFLHTITISQKYYCSSYDSIDEYNNNNNNNNNDNDKNNNDNNNDKNNDKNNDKNNDKNNDKNNISKSNHEINIILNQTNDVLGKYAKGKFQNKKIYINKSNYYNSSKKRKLSVSIRHKKKKKTSKLFAVYFGHERWDLVMNMMIGIRICAIKKFNIDNILNYYKHTDVIQLSTSRPNEKVLFKNYSPIIFKNIRKIFGIKSKEYITSVGPEQVISNMVLGNLSTLSELLSEGKSGSLFYFTSNGKYIIKTVNKGIHKLSKKLLPRYYKYIQKNPDSLLTRLYGIHSIKYLNSSSKTIKKIFFIVMNNFFSSAVEIHRRYDIKGSLIGRTVPPEKREDHTIALKDADIDELGDVINIGDENKEKLLNILKSDANFLKENLLLDYSLLFGIHYKELSRDVVCWDKKKTNEIRHVYDEFGLCVAAKPFHQWDHGGMINIDKNRIFFFGIIDIFTKWNLKKKIEHTFRTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPP7</accession>
    <name>V7PPP7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPP7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00139">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="8">
        <location>
            <begin position="810"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1139" mass="132404" checksum="51C7C17C0E3521A4" modified="2014-02-19" version="1">MKCGNVNVRNVLEFNLKKNIKEKTKLTDQEIVIIYKRFHSISPNGKLDYKQFEKSLGILGTIKNAYLYKCIFKAFDLNNDGYIDIFEFCVAINIMLKGNKRDKLKLSYRIIQSGSSVKLENLQGEKHSKGDKNLQDEKHLQGEKHSKGDKNLQGEEHSKDDQILKDDKNYLEYINYDDFERIILSIKDIKKQLLGEDDEIVISHVKYTFKSLSILCDDGKDLPENGDEKNGDVKSSNNNTFKKDDIVPSSSEKKLYLNNISTKYNSISQKKQTKDDENELFESGLNNKSGKKILRKIDQIKLDKKINKRCDNIGNDFKKLENQISQNDERTTNIYYDVYKEPEIKNKKNVPNLDLAHIEQEYESKSYMYSTVEKKMNKNGSMNKSGSMNKSGSMNKSGSMNKSGSVDNTEFFDLKLQIFEFEKKEKNKKYIDTWNLYINKYKEYIKRVEEVETGENANGNRDGNASGHGNGCVNGSFSDNLVESNNIEKYYDKCNDIDSIDSDNNSNIYEKDVEGESVESSVSTYTKMSDKINGDIIKLIENQENESNDYISHGSNKKEENSSGTFLFEKYIEYHKFVNETEDIKTLINETYKNSQQLELSSNSQHFLINKNLSKEKLLYHIRIILLNVEDCLKSDKDNENYDKIFLIFFYIFIYNNTHEENTKIESKQVCIRDKHLKKYKSVLLIVSIIRYFLHTITISQKYYCSSYDSIDEYNNNNNNNNNDNDKNNNDNNNDKNNDKNNDKNNDKNNDKNNISKSNHEINIILNQTNDVLGKYAKGKFQNKKIYINKSNYYNSSKKRKLSVSIRHKKKKKTSKLFAVYFGHERWDLVMNMMIGIRICAIKKFNIDNILNYYKHTDVIQLSTSRPNEKVLFKNYSPIIFKNIRKIFGIKSKEYITSVGPEQVISNMVLGNLSTLSELLSEGKSGSLFYFTSNGKYIIKTVNKGIHKLSKKLLPRYYKYIQKNPDSLLTRLYGIHSIKYLNSSSKTIKKIFFIVMNNFFSSAVEIHRRYDIKGSLIGRTVPPEKREDHTIALKDADIDELGDVINIGDENKEKLLNILKSDANFLKENLLLDYSLLFGIHYKELSRDVVCWDKKKTNEIRHVYDEFGLCVAAKPFHQVCTFHLCAMLLFFQRASICLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPR0</accession>
    <name>V7PPR0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPR0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB61419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="179" mass="21064" checksum="416A1E93041201AB" modified="2014-02-19" version="1">MVIRKHCENIGKVKRVVILEDEHNCKSLGICLVEFYYLDNSQNYVAYIKEKLKADVKTVDAHLEEQIKNDEIYNYGGYLNSSIIELIKRNNSEYINTNENVHDVLNKSMSLNRHPLFTWFNTSLKDVLNSYVKSEIKKKKKYNNDFLEKKYETNSDSDEDISTHILDYVAKKNKMTLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPT9</accession>
    <name>V7PPT9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPT9"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26900" checksum="50B1DECAC6D61297" modified="2014-02-19" version="1">MHKSSNYDCTFSPTSILFHKFLYTINIIIIILKEVLVYDIHKSLNDSFKNILDTIIIIGIIWILSPVMISLTQTHSDDTVYLVSLCILLPIHFMFHNYGFIYEKNENIDIFDSTSLSCVVVESVILGSRLPSIIQVFSFLFCSSILFFYTPFIVQTIVLKNINYYNYVLFPIIFIILSICIRSISIPLFYVNLFGHAFILFVIPALFVNKHNSKTVLEGPWDISGAPFVQKNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPU8</accession>
    <name>V7PPU8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_01462</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPU8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="10">
        <location>
            <begin position="705"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="500"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB61606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="846" mass="99958" checksum="1BB8FA41E62B94D1" modified="2014-02-19" version="1">MKKEITFNVCYGEEEEKKNVVGLLVENNFDEVYEPLTSESLRFFLPLNGLYVIDYQLHFFKYNDIKKIYIVVTHHEKELQSYVEKFQKSKRKYNDLDIEIIKMNKKTKSLGDVLRDFKKCKDVYDDILLLLSDTIPISNIKEIIKAHFINKEKCKNQIMTLLLTHDTNDNMKNQDEEFVIAYDNFTLKLLLFEYIKNKNYISITNEIFDQVNNNSKNVKSKKKENKPFTQVNNKKETAVGERSIFSTLSSSASSIIISCDVLIPNIYIITPDVLKLFEDNFDYQCIRKDLIYNILKQEIKIEEIYVHELNDDHNYTECNQMIVTLFDFRIYYNFYKTLIEKNIHPFLSKAHHLLPDMPQLIYTEPGFYRSKNSLFSDDCKIFKSSSIENFSEIMNDTTIENSTICKNCKIHKNVTIVNSIIGKNTTIKSNVVILNSFVSENVIINKNVFIDEGCIIGKNMNIPEGLRIKKYTRLSNYKYEMAKGKLAEASSHELEDAKGKETKEDIKEEIKEEIKDEVKEEIKEEVKEEIKDEVKEEIKEEVKEEIKEEVKEEIKEEIKEEIKEEIKDEVKEEMITVNVKEHAEGSKVDSEQERVEEVMIDVEEAKKGEEEEFNIENYIVKTKYSDEKLRSFFFYTHNSEDDKKLKTLSSLEYDSDDEIESSSDYSGDKEYDALYCSDENDNESETHDNNNFGIEYDNSNETSIESEKATFDNEISLLCKEAFEKPQFMNHKILEMKSFRLSQNYTDLDVIISFFPIFWQFINNLEFEKDTWIDKFDDTKLDLLFSSFLIDEPIYYETIYDLILEFSKKTYLDNNVKNNIHGPSRLCNTFEYIYHSDIFEFNHFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPV0</accession>
    <name>V7PPV0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-7/Ran-binding protein 17 TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPV0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000332">
        <property type="entry name" value="Ran-binding protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057947">
        <property type="entry name" value="TPR_XPO7/RBP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25795">
        <property type="entry name" value="TPR_XPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exportin-7/Ran-binding protein 17 TPR repeats" evidence="8">
        <location>
            <begin position="478"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1119" mass="129864" checksum="33EA2AFD154A9509" modified="2014-02-19" version="1">MSEAELQQLQVLCEAMYCGNKEEQNQAHTILLPLVSNVGNVSKLKNILGSTTHVHTLIFTTSGLLQLITNEWNKIENNEKEELKEFVISYLYNKGVELLNLSSNILGNFVRLYVRIVKLSWLENTNYALITKQVEYFLNSVTSHWIIGLYIYAALIEDMHPQCGVNSAKSRRCAISFRDYVLKDIFKVGIETLEEFVKGSIRIELRVEENRLLMKVLELIYNSLSFDFMGTMINDESSDENISLMIPQSWDIFNEKNIPKLFFDMYEICMSEVDDIRNCCGKYCIRSLILLGSLRKTFFSNEKQKIRYMNEFLGGINKIIEKKIGLHDEDCFHELCRLIGKIDTSIRLQELSTYSNFLSWCNNIYLFTMDGMKNWKYLCNSKHYLLGIWSNMLNIIPPKIIKEINSKTDEKELLNDVMNNKNFFIKKNNSISNSFNTNNDIDNKYLIICDYIYNITIVFINSRLELAKYICETGDSCEMENPLYNDVLRSEQLELISNLCKLQYNFIGGKILSIFYELKNNHENNLINKSVFIEQTTWLVFIISSIISTSAISNMKFANSDNFKINSELCFLVFSLMEQTNKSSEVFEYLEFAYLNCLELFKKVYINGKKNNNFLKEMRSIASRIISASGNNNSITNSSNNNVNASGNNFSGSSLISSKNDEENNDPLIDLIISKILFNLNNRLEYDQIIKRSLDLFHDLVSGMNIVCLEDKTPKLIVFARLLLKNEKILKLLHSRDTKFLEVSKYYKYRTNYYLILTKLLFMEQNTNSLSFEEYISPINNLLECIKREIDINGKDIILKNNAIKLSFIGALRDLRGICMACNNVETYNMFFNFFINSHPLEDNKMNILTSLVEIIWDTYEICVPFLKFMCEFVYNKSQRITFPKSSPNGILLFKVVSNILIIISNNLLQKDKFCDIYKEKYKIISLLLNMFNNCLNGDFVNFAIFDLYNDDILNNSLNLALNMCLVIPTNDLLSYIKHLKPYFSFLDLVTKNFFQRILNLEFRLIADIIHNVKEGLCSFDYTVSMTCCSILDNIVTYIFTNRKSSSEQGQIIKNFLENQPQALKEVLNLMFHLILGGNFGSTWSMSQPLLGLILLDAQGYFKIQEQLISQQSEEKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPW1</accession>
    <name>V7PPW1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPW1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1109" mass="130857" checksum="D60A70CEC1321C2D" modified="2014-02-19" version="1">MEKNGISEPVGMINDAYFCKAIKTELKKLRDEYLKRVKNNFLSDYIFKTEVFCISFFFIPLIAGRIVLQDNNIISPHFLTVLFLLIAFLLVIFVLLYFEINEAQNREFVKKIEKAQNILSVRNILKNKKDDSHFNYLTTSNFIFILRNNKWELLPKNLLIKNDVFLLHDGDLIPCRCVEYNIYENVYGKEYQRNEVFMAMDKYRVSINIMTKYSKDEKREYLPSFHLYAFVSYDNASIYIIRKCINEKFDKSKSSKSKENLRNVVLEEKVHVIFIYIWIFIFSISTALMFIYVSNLRKIRDIPQYLLIYWLAYTVLMSMSILPFIHRIFSELIYGYCSSLSMSYENYFKDITNYEKKSFTSSFDLSSATENSSFVIEKKLALFYTLKSIFLLIFKGIKINKCYLNILSDCSVLCFLDSNGILVNTNHSVKEICIYNQLNNKKNVNDNNNNMKKIHNYYNNILTIIDIFMDNKSMYAYQRIQNIKILHSLFLISYFTQLLKYIKNLDDFQNNILNYMNHQDYNHLYTCMCDIGNISYPYNKFSFRMLFFCIENKSDYELYKKKNLELKRNKKGKIDGEIPYYVDKNEKGNELGINIYDNLITRDNFVFIFILYEKKKNKYHMFFKGQLDALVSKCMFYYDGKMIKKLKRRKKKVLKILNMQWISSGLESICFAYRPLSTDEINYLKTNFTKNIYILTINKRKVYNIKNFYNEPNFPCKENERFLSHLISTSIFIGNSAVKILTSNDIQARINDFYDAGIRFVYFSNKDQINTRNISNTLGMETNWNTSISLSLNDKSSFRNRDGKVVIPSGINNIKTHIQEIDDIPLRVSSYSGCNQFNTAEMIKILLENNEIITCVGNSLNCCNFELYKLCNYSISVLLPYNNICTDCYGKKERSNPFGKPAVNKNPLIAYSSFVNSFPCNLTIEKNILDLSENIMELVYKLLKSSRIYKKNLSISMFYFYFYYCYLSFLLFVINVFFLPPLISLVDYLLLILFIIPILSISLLNNNNNSTIMNDIPDKVISIDFLVKKLFFFLIRWVSFLTFSIIVSVYYIHILNDTFVDKYVIKGTLNSDKLSSLGQNFVKDVIYYCSKNINISRENLFIYSQCLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PPW2</accession>
    <name>V7PPW2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">10 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_01476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PPW2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB61621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11098" checksum="B3C78348C9650C53" modified="2014-02-19" version="1">MASSIAKKFIPLMDRILISKIVPKTTTKSGLFLPESATEPSYTGKVLAVGPGRITSNGNKIPPSVKEGDVVVLPEYGGSSLKIDGEEFFVYRDDDIIGIIKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQ19</accession>
    <name>V7PQ19_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQ19"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="617" mass="72098" checksum="A861EB9E9ECFFC2F" modified="2014-02-19" version="1">MRILLFGDENFSFCNDFLAEHENDVVEVCSCLKENELKQEAKNNIQELSKNIVIHYGINPVQLKSKFAPNSFDVLYYILPGLSFHGYPDFIDPQTEMFKLRLNLFTFSFLKSSKNIIKPDGYVYLLYPEENQKIEGNSAETTASTANNETESINDNNENHIGEGKDNDSEKRKFNLPFLPIEPKKLAKFCNISREYSKDYYLNLSNHEKWLPVLFNMPIVNELPEWIKTCKYYCFKMTENTSNKNNSANNSPQENRENQIKEENNVEGEENKENENDSKREDEKRQDDNDEEQNENNGSIENTNKNDENYNEDEKEKGNQSNEKTKENGIEQVKDKEDPDEYNVLKIPPQVFDYPIEKLGHVNECFLFKLYSVNSKSVLISRLTLKYDPRISGWKGDNKIKKDMMNTSMGMNMNNMNMMKNMNNLMNMNKFKGGKYKNKQNKNDFQQQYKNNMMQNNMVYGLNKKGNVNLPPPPPTNLNMQANNVNMPNQNMNYKQAKFPFVNNFKVIPNNLSQNVQNTMTNMPINVNPNISNNMMNPYINGGYNTNFRNNMYQQNMPISSPMGNFNKKMYQGHNMNIKRKNDSFNCDSMEKSYDNFNMKENYKSDDDNSNYLISHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQ36</accession>
    <name>V7PQ36_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQ36"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043489">
        <property type="term" value="P:RNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00164">
        <property type="entry name" value="S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15838">
        <property type="entry name" value="NUCLEOLAR PROTEIN OF 40 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15838:SF3">
        <property type="entry name" value="PROTEIN PIGMENT DEFECTIVE 338, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="616"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="783"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1103" mass="131528" checksum="C4BD9283E42F7BF8" modified="2014-02-19" version="1">MIFTKQCLFLSFFVLIVSSFLKRKLVLNNYIYSKTNRFKKRKKIVNYQLVKSKDKDVESYIPHIYKDIAPSLKGLADQEYSYKQLLNAYIPETIEREKRDKLNKKSNQKNNKKQSKENRQTNKNNEIDEKEENEENECNKDLSNNIDKMMEIKMKENDIKHFENLSEISNHKKKNKILDIAYDVIEDTLKNTYMNQKLGLDNENNDSKKDYLEIAKKRKDLLYDKLINNYSMLNNSSTFDLFGVFYDNNNYKDDNKLIEELDKIMNLEPFKSNKDNIDEDIDALLKKDKIPTHIRNFILKYKNLRKINMSNNKIDHMKKNENEQVKESGSIKQMDNDGNVDDEKEKDEENRNYEKNIKDENGENIYNDFNRDLNKVLMTFNKNLTNEKLVKRDKYIIDELYEEYKKHIKNMNIKRNKLEPQKDNYDFLTFVHEYGEEFFFQKYGYFDNYLKENVEKIKNKVRSENANIVSIPNIMNSEPNSKQEKSSTITKSNDPVNNIGNEKDNIDEDFLNDSPEKKINKKNDEKNNTQMRNNLDWRKESNKLESYMLSNIVHEYNKRIYDIYKPNDMITNHYGFNNYIDNEEYDKDINVSLNKYSIMNYDSKEELNNDESLYVGKLIFGKIFKIEKNMALVDINYSHYGEIHSDQMPYNITNISDVFKVNDKLIFEIYKMYPNRIELTLKNIQKINDLNKILLYKTQDIPFEVTVLSIIKNGITVSYNDIYTFIHISAISSKYKVIVDENETIDSNLLNKKIKVFCTDINKLSFSNLLYEQNEQLKNINMYDVIDVEIIHISKYGLMVKYNDIVGLIHVSEISRKKIENINNVFKINEKIKGMLINIDYYNKRFSLSTKILETHDKNFIDNREDIYNNIEHIVNNIKKRSNKMEVNDSNIKNQLLSLIDIYKDGNGSEKVKTEEGKDETTNQHKKIQEEIKLYDNEKIDKHPQVTSEKTGSQTEHITDIKNDNNIIDGEEKYNVNSIDNDIKKMQEKYQNNDDDTLSELNQSEEKEELSIDVHNELVPYLLLKQSDSNKEEHEEEKKEIVWNLDDEEFLHSNSPTQNSQYIEYQWSYLKDKKWVSFPYHVNRIINYYFNINDDFFTYKEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQ43</accession>
    <name>V7PQ43_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQ43"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="124" mass="14569" checksum="CF8E7B612C4C018D" modified="2014-02-19" version="1">MVTLATKILYFTYGRYLGNFMFDTFLFFSNYLNLVCFVLKKISNIFDVTNYRDLCNKSIHSIKPPNFKGIIKENKNMHFFNVANVNDLEFYNSSILETETEINEKAPTEFDDFGDDEYNFVSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQ51</accession>
    <name>V7PQ51_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1355" mass="162544" checksum="BA17C3F624BAEB57" modified="2014-02-19" version="1">MIYDFLNNNKKIFLIKNIDNIYEHLKKENTNLNIDNIINQNKNDLVLSQIGKESLKKYRKKNDKGLKTNILNYLSYRHPIKKLTNDEILNMIKHYNINKLPYNLLSDHNNVEPVFINNYDNYIANDISNNSGDDDNDDKQIKHNKSFYNNQDSFINAEDANNKTKYILYNFECIPFSKSKLYKNLKSLFTNVPLNYKLYKLINEKCWKNGHILPKKGNDYIKIIDNIIHDSKSGKENSKTNGRDNDKENSKTNGRDNDEYIYMSTDADSYKSDTVYNIKLYKTELYNKFKKYVKKNINKLNLVTKGKPHCYINKCGDDNNSEINNSLFHDICKTYLDFFQKMDDYFYFKNHQKNNNNHTDYSNIIKYKYGKQNNLNRIFEWHNNLDIYDPLLTLNNKSYINEKSGKKKKTWICIYNDRSYVNINNPSILAEINKKDKKESTSLNYNLNKNVHFEFNSNLYCFILRFKNNYIKNKNKNLYIIIKQNKIYKIKYVQNVKQTNKYTYFLFSCLIFPVYLTIKIMYIFALEYFPSLFFKTLNYLNYLKIDEDFFDFLQCNEYKTINEIFYNYNIKDENNLIDVLRFRGNYINPFSLLGSIFYISELKNIAFYFNLHPTNHFNTMHNVWGIERTTNLIHLEKLEKKLKKKKINKRILRSFHGFNDSKIPMLTQKKSKDIISNNSNNRDNINESNQKGQIVKNNVKHVENENNYKVMLRRSNNKRDVWIKRTQCDDTRINELFYIRFEDDSENNIKDEEVEKNVIEIPNLENLENLENYDNTEKINKRKKNNGKHTKKNFKHLLNKYLEKQMHTNYYKNYSNESETINLYNMIITFLNNKALFNNDSITYEKYIKKNSIEINHNIYREFTIHSNYYMQEFDIYPLNKFANTFYNNNFKILYLNYQKIKNKKHMTPDHHQKVEYIQNIDNISKTSNNLSIAPNYENEKVSYDGIEENYGENYGGNHDENYGERYGEKAKDEYLINDNDNVYDNLLDPLGNNIEKDESNKYENDIISQIGDLDQIGDLDQIGDLDQIGDLDQIDDLDQIESIKYLSGGDSFDVLNENDKNSINKSDKESTSTYLMENDKTQNSDETSEYEDGSLFDSEEEHNGKDYISYSFYLHKPVYIFDEEKEMERALSGIEDEESETDDEKRKTKDEITKKIRDTNKWNSNIFLKKNKQFKKVYKKLIKKIEYDRNTKSICYPLYDKNNKFLMRDYKCIKQENILGKFTKKHVIRVGKRKPIYNLLKGRHLLINCISNNFYTYDQEVRTIVRMYKRHKFLLKNQKQKYFLKKYKNSYPWIGENMFICENDINKYISAAYSTILFHKNTTYLKHFTYHSAREYIPSFREHRNMELGKNINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQ63</accession>
    <name>V7PQ63_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQ63"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="481" mass="56759" checksum="B64B3154014B2757" modified="2014-02-19" version="1">METLKEDDEFFVEKKQLNALNTYFSHSLLYLERLESVIKNINIMISDLNRCLMSFFENDINLGIVQHISHILNTFTDVREQITNHIISAKSVTNETLEKIRKIQNLCLKKKELGISIEHYEKKIKKLQQVNSPNQKHLEKIIRNESKLNGVKSDYLKHNEYIKKGFDIVLENKTNKVLLDARKDLELLLCYFSLMNSVSIKLKDPLKDMYLNTQRGRLPIDDNFFLESEDRMNYFYEMEKNINNYNQLNRYNMYNPQFEYNNYEQNINKFNKYDIPSRYRTYDHIPNIYNEYDRRNINNCNYNNNKNNNYNNSSSYNNSSSYNNSSSYNNSNSYNNHVLDNYDKYNGHNNYREIYYKNGSSKDDNFFTTSLNTLTKTISCNLNNTISKINKNNNLNRSGNSDERSSSSSNHHLPFIKNIKNKIYKKTLSQDLFIESDDKKDNSFLKIKNILGGSNKPKEEEKENSPPTTTHPATTPPAFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQ64</accession>
    <name>V7PQ64_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone chaperone ASF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_01564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQ64"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000002">
        <property type="entry name" value="Histone chaperone ASF1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB61736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25466" checksum="610D339F8D287084" modified="2014-02-19" version="1">MSEVNVTKVIVNNPICDILDPFVFTIEFEALNKLEADLEWKIFYISAVSNEGESNQDIELDNIYLGPIERGVMMFDYAVNPPDYKNMDTDSVLGLQAILISANYKEKEFIRIAYYMNSFYKDIELREKPPVSPQYDKICRHIFVDNPRIVKFSIPWDSEERDEFKEFDKENEKIELLNFSKIKEENQSNSNITNQSTQDNIFVPNGVKEYNPNNDSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQ83</accession>
    <name>V7PQ83_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQ83"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1151" mass="124881" checksum="F4B748DD6BFC9678" modified="2014-02-19" version="1">MIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSVPTGGQSGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PR20</accession>
    <name>V7PR20_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_02154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1114"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1123"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB60793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1336" mass="155437" checksum="9865AF3B1AA792AB" modified="2014-02-19" version="1">MHRFKIYKIQMCKYALINKCDRGENCTFAHDINELRIKPDMRKTKLCKSYILGRCIKGNQCRFAHSINDINTKLVQFYDCEDNIVSEINNISNCDNNSLNKISKEKQLMVNNMKNNNSNFEIECNIINKRNELLDCMLMENDSNSSVLSKNIVIRNFVTKNMQNNGQNNGQNNGHNNGQNNGHNAYRTNLVKTESNILGYNVYINDKKNDINNQNEIIKDTKLSIININDNVKNNRKKNNLVSISGDKNEKNILNHGCDSKIEDNISILRPSLNFPKKIKFNYGEENIINNNLGLKYNNIQNMSNNNILDNYNNMNNMIDVNYYDKKDNLNYMNLCYNDNQEDMSVETKFNKYDRIKNDNKLNINLFEKEKINLTKDEASYFQIENKTKDKTYNYKLKKCYRNDYLLNSRENVIYDYDGYISSSRIDNKYENISTCFDLKNKKTNLGNNINYFDKKDLKNNDLFYSGFREMCEFNLGSNNEGNNTNCIDAVMGSMNIGNGFELHLTNPNYEDIDKEKEQYELENKYKIVEPNKDNENDKREIDFIIYKEHQNEKMSKNGQVSKANALLNNDDNENGNDNDNENGNENGNGNGNSDNSEKYLNMAIQNISRISASNFVENNFKYTKDKEKNSTEELGKPNSNFSEIDANSGFKLAEIDANSGFKLAEIDTNSGFKLTEIDDCVEFGVESGAVENGINESYLKVGKVEKIGKVEKIGKIGKVGKVGKVGKIGKVGKIGETETRMISNDCFDENKNEYLDHIKMSGIGNNNMEMNKIKNNIRYENNGNNYFENDMYLKKYIFKCDERKIINEDNNFDIYINRNYIDKIPKTKNNNLIISKSIETSMNQDMITSNKNKMNTFNNLNDNNNRSKENSINILNCFRDIMNPVESTNKLNNFDKKIKKKKNEEIYENEYLKKENIYDDSDRCENYSIEKINNEIENVYDYNCDENHNLNDIKKLTTTNSKINYMELNKNIKKNSMENLNYISTFDCCRGNVNLKNKQNEINKCLMAKEDYNGFYDNYKNDVAASILQKGHGNAGNGDGNSVCNGMGIKKGCLLIHNEESNKLDNKFEIINNRKEKRNGSIIKGILSKFSEMNNDENGNELNSIEIKHSSTKTLTSNIYENENEDENEDENENENENENFSNNCLFEVQRYFDLPWACEKKEIENSNTYNSNTYNSNNYNSNNYSSNNYNSNNYSSNNKCGFYESYKNKTNKQKNNNNFKDNVNKNDEMIYSYMNQEYNMLLQNDNDIENLIINRNCLNNLSNGYQNNIYNSSDFWEQPHLFNYENVNETNNNKDIYFDNNFFFENKDFPLDDDTEYSINFSGDMVFNFAKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRU6</accession>
    <name>V7PRU6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein S-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">YYC_01369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="2"/>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRU6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="86"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETB61477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="965" mass="114140" checksum="B96A917E4FE2344F" modified="2014-02-19" version="1">MMVIPVAIFHAFTSPWLFKKDIYLVTVFNLLFFVLTIYTFFKTSFMDPGIIPRQNSVLNLYDAIIDQRRGAQPPKQKEVLINGVFYKLKYCYTCNIYRGIRTVHCSICDNCVEKFDHHCPWVGNCIGARNYKYFIYFIFNLYILICITLAASIYKLTICMTALSNKGYNSEKIFIHIWSLATDSIILIIYTVLTLWFVIGLLCYHIYTIVTNQTTYEQIKTFYQNDNPFNIGVLNNIKEILFTKVRPSYINFENPKLQVIDQYSSHNIITYSDKSISIDQGIANISLPVSIDDKESNIIKDDIIDDDIHYEIEMKTDSQLLKNHDDEFIEKNKNLTNKNAFLSTERKSLKRVKEYNSLNSLGIDTESKSNNFKNKRISKKKTEDVDSPKINIISNRGIGKTVRSKDYKNKIITKISKIKLIKTIKKNLSEELNNDIEINNYQDKCIIDVNNNLGSLYIKNDVSSGSKTNNEVFSDIDNELDGTYYYSSRANNLADINKRTNEKKKKKQNKKYYIISIKNWEKNNTTTKIVENDKDYYNDNNNNDIYNMNTHKEKMIETNKIHENIHESKNNHYNNITRVRRKVEYKLLFKKKFPFILKHKNKIQTFYMIRDPKTENKSIHPYSTGNIEHENPSEILCMDNISIEDNEKEFKKINYFKKKNYHKIHQSNYSETNTNKLKNVISEKYSNSDFLNDINCNKYDDTNISNCNVKHGNLGKRESKESNKKLNRKRKEESIIDIRKNVVLCIYNYNTKGNSGKLPDKEKKITNLEKKNNLECKNVIYNIRDKKEKLITLLKYKRKGKKKHDSKISLAYLSQINNMDFDNFSQIYKRRYTKIYQWKCKKIQQEIIRRKKIKLLSRSSHKNIHTYYNNNKYFLENLNNLTDFQINNNELIKRYYQHDSLYSTAIKYNQFDNVKLYSYLTHMKNAQNRSDIKKKSKASKFFDLFTTFALIINCINIPSNNDNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRV6</accession>
    <name>V7PRV6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">YYC_00772</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="4"/>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRV6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000027">
        <property type="entry name" value="Cysteine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="15">
        <location>
            <begin position="36"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Cysteinyl-tRNA synthetase class Ia DALR" evidence="16">
        <location>
            <begin position="401"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETB62144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="579" mass="67521" checksum="0433A708E6A7D601" modified="2014-02-19" version="1">MEANSNLPKWTMPSKENKTITNLMVNNSLTHSKVEFVPQEGNTIKWYACGPTVYDAAHLGHARTYVSFDIIRRILTNYFKYDVFMVINITDIDDKIIKRSEEEKVNFTELARKWEYEFWEDMKSLNVLLPSSITRVSEYVNEIIKFIEKIIENKYAYVSSEGSVYFDIDAFKKNPNHFYARMEPMSVKDETKILEGEGDLGVISKNKKNSYDFALWKSSKPNEPSWDSPWGKGRPGWHIECSTMASNILGNVLDIHSGGIDLRFPHHDNELAQSEAFFDHSQWVNYFLHSGHLHIEGLKMSKSLKNFITIKSMLKKYTANQIRILFLLNKWDSFMNYSPNGEGMTQCIEIDKFFTNFFALINMKIKNFDLNNCDLYWNDTDNKLNNIFRQTKTNIHNFFLDNFNTPEALVAIQKLISEINIYLQNGKIQIGLLLELKQYINFIMTTLGLFYDEAQKTKSNNFDNLLHVLGSYRSNIRAILQKNAKLIRKISKGIKTDTSDTATLDNNNKYNEFIKEIKTNNEELLKECDILRDQHLLNMGILIDDRPNNEFVVKVLDANQLQQEKEKRECDLNKKKDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRV8</accession>
    <name>V7PRV8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRV8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="181" mass="21475" checksum="6B2C9AFA733B6E3C" modified="2014-02-19" version="1">MILKDNKIKASNIETNEKKEDEIVINEDKEMIDNNMTNSQMKGTNENDESSNISKLLNNLKNYDNFMELEKQREELKRKEEEDKNLFSIKEFFRIIQIPNITNEIKPAGVLNAFEIFDEKGDGKISIKKLRFILQYLGEPLSNSEFDEFFEWLKTKEKVYKTDYIIYDDLLNELINKDTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRW5</accession>
    <name>V7PRW5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1384" mass="166058" checksum="97CCC3604D051C03" modified="2014-02-19" version="1">MIYDFLNNNKKIFLIKNIDNIYEHLKKENTNLNIDNIINQNKNDLVLSQIGKESLKKYRKKNDKGLKTNILNYLSYRHPIKKLTNDEILNMIKHYNINKLPYNLLSDHNNVEPVFINNYDNYIANDISNNSGDDDNDDKQIKHNKSFYNNQDSFINAEDANNKTKYILYNFECIPFSKSKLYKNLKSLFTNVPLNYKLYKLINEKCWKNGHILPKKGNDYIKIIDNIIHDSKSGKENSKTNGRDNDKENSKTNGRDNDEYIYMSTDADSYKSDTVYNIKLYKTELYNKFKKYVKKNINKLNLVTKGKPHCYINKCGDDNNSEINNSLFHDICKTYLDFFQKMDDYFYFKNHQKNNNNHTDYSNIIKYKYGKQNNLNRIFEWHNNLDIYDPLLTLNNKSYINEKSGKKKKTWICIYNDRSYVNINNPSILAEINKKDKKESTSLNYNLNKNVHFEFNSNLYCFILRFKNNYIKNKNKNLYIIIKQNKIYKIKYVQNVKQTNKYTYFLFSCLIFPVYLTIKIMYIFALEYFPSLFFKTLNYLNYLKIDEDFFDFLQCNEYKTINEIFYNYNIKDENNLIDVLRFRGNYINPFSLLGSIFYISELKNIAFYFNLHPTNHFNTMHNVWGIERTTNLIHLEKLEKKLKKKKINKRILRSFHGFNDSKIPMLTQKKSKDIISNNSNNRDNINESNQKGQIVKNNVKHVENENNYKVMLRRSNNKRDVWIKRTQCDDTRINELFYIRFEDDSENNIKDEEVEKNVIEIPNLENLENLENYDNTEKINKRKKNNGKHTKKNFKHLLNKYLEKQMHTNYYKNYSNESETINLYNMIITFLNNKALFNNDSITYEKYIKKNSIEINHNIYREFTIHSNYYMQEFDIYPLNKFANTFYNNNFKILYLNYQKIKNKKHMTPDHHQKVEYIQNIDNISKTSNNLSIAPNYENEKVSYDGIEENYGENYGGNHDENYGERYGEKAKDEYLINDNDNVYDNLLDPLGNNIEKDESNKYENDIISQIGDLDQIGDLDQIGDLDQIGDLDQIDDLDQIESIKYLSGGDSFDVLNENDKNSINKSDKESTSTYLMENDKTQNSDETSEYEDGSLFDSEEEHNGKDYISYSFYLHKPVYIFDEEKEMERALSGIEDEESETDDEKRKTKDEITKKIRDTNKWNSNIFLKKNKQFKKVYKKLIKKIEYDRNTKSICYPLYDKNNKFLMRDYKCIKQENILGKFTKKHVIRVGKRKPIYNLLKGRHLLINCISNNFYTYDQEVRTIVRMYKRHKFLLKNQKQKYFLKKYKNSYPWIGENMFICENDINKYISAAYSTILFHKNTTYLKHFTYHSAREYIPSFREHRNMELDKIPTMLFLLIKAFSVYLNCSFRELIIVITYIFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRZ5</accession>
    <name>V7PRZ5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mic1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRZ5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040371">
        <property type="entry name" value="RMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009755">
        <property type="entry name" value="RMC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897">
        <property type="entry name" value="COLON CANCER-ASSOCIATED PROTEIN MIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897:SF4">
        <property type="entry name" value="REGULATOR OF MON1-CCZ1 COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07035">
        <property type="entry name" value="RMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mic1" evidence="2">
        <location>
            <begin position="614"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="808" mass="94832" checksum="364BA69F7CDB0B75" modified="2014-02-19" version="1">MNIDNVIKNEHTGIVNKRDIQEGDNLSKEKKRDEINLLNKQNKEDKEIRRTKSISTYSPAYISEPIYQWEVSKNDRIFYDKINDFIIHQNVLTKALLVTDIKKTEENYKGVYVKFDKNLCEHICFSANKSFFLYYSTNPNIIEISDILNNHNIYLNVEINKLDECEILSAFWLNDNTLKGLNGNIASSDFVVITNNSIEIFNISFDNLIINPLKKHYIKSKYSWHNENTSYIALLSLTKNNVILPYLLNNNNAIKLPKIELNITQTDNINKNDIEIIILYNETYCIHKDFKNGRISFRCLSSIVYFDYVLDLFASGMVDTFCINNLFGVFNYINEQIYIFDIKYKKQNSITSLNNNTVNISYLTSPKAFKRNINCNYIFFKSPNIIIDAHYGNIYSINIDYDILMLQICQHFSNLSTSVDVLLRRPDCKKRITEMFFLALENYIKIEDFLTIINIININYRKLIEQCAKKGKCSTTITRQKNKIIQPLGEVLKNLDGKTLITEKDIVTEVFHPFIVKKYNLNKKETLFNLSINFLEMKMAKKKNKAGKIKTQCRKSGGKSGEKNGEKNGEKNGEKNGEKNGEKKEDTINEELKQISNFVNIQNSNDNMINSDNSGIIQNNKNESIYHESLNYSELQNSSLFLIYILEYMKSLLYLNIIPNRILQTFIFDVCVFFKQDNFLRQLLQFYVISDSIEVTKRLFHYWQFTKYVWAYQFCLDMSLRLKEYEMVVHLFLSAKKYLKIIKFLRNYNLTDYPISVIFQAIENDLDSPKKYTILNNVLFSLNKWIIDSDKDPVKYPLPNLQVNNFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PS56</accession>
    <name>V7PS56_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PS56"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008536">
        <property type="entry name" value="DUF818"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05677">
        <property type="entry name" value="DUF818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22337" checksum="94F5527840B0C3BE" modified="2014-02-19" version="1">MGNILNKIIFNAPHEGIYEKLDIDFIYIETEDNEKIAAHYINRNNLLTVLFCHGNSENIYMLYDYFYEVSEIWNVNILLYDYPGYGESTGVANEENMYKSGYAVYDYMVNTLNIKPETIILYGRSIGSCAAVDIAINRKVKGVILQSAILSLFNICFKTRYILPFDSLCNIKKVSSYLYISLYILPIRNYTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>V7PS57</accession>
    <name>V7PS57_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Splicing factor 3B subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_01663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PS57"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000031">
        <property type="entry name" value="Splicing factor 3b subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000640">
        <property type="entry name" value="Splicing factor 3B subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="8">
        <location>
            <begin position="14"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="9">
        <location>
            <begin position="444"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="7">
        <location>
            <begin position="873"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB61855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1098" mass="124391" checksum="94242BF7178A496C" modified="2014-02-19" version="1">MPILYHLTLQKPTAITRTVYGNFSGPKAHEIVVAKGQVLELLRADKQGKLNVIVSKDVFGIIRSLEIFRLLGSNKDYIAIGSDSGRLVILKYDDEKNDFIRVHCETYGKSGIRRIIPGEYIAIDPKGRALMLCAIEKQKFVYILNRDNKENLTISSPLEAHKSHSICHAVVALNVGFENPMFVSIEQNYENLDKQVLNANEQIMEYPKKGLCFWEMDLGLNHVIKKHTIPIDITAHLLIPLPGGQQGPSGLIVCCENYLVYKKIDHDDIFCSYPRRLEVGEEKNISIVCWTIHRIKTFFFILIQSEYGDLYKIEVNHEDGIVKEIICKYFDTVPIANSICVLKSGALFVAAEFGNHFFYQFSGIGNDSNDAMCTSNHPSGKNAIIAFKTQKLKNLYLVDQIYSLSPIVDMKILDAKNSNLPQIYALCGRGPRSSLRILQHGLSIEELANNELPGKPRYIWTVKKDNSSEYDGYIIVSFEGNTLILEIGETVEEVYDSLLLTNVTTIHINLLYDNSFIQVYDTGIRHINGKIVQEWIPPKNKQINAATSNGSQIVVSLSGGELIYFEIDESHTLTEIFRKNINVEILCLSIQQIQQNKLRASFLAVGCLDNVVRLLSIEKDQYFKQLSTYILPNNSSPQDICISEMKELGNQKEHTILYLNIGLNTGVLLRSVIDPICGTLSNHYSKYLGAKSVKICHVQVNKNPALLVLSEKTYLCYVYQGKYIYSPLNYDVLEYASSFYSEQCSDGYVAISGNSLRIFRFYRLGEVFSQNILHLTFTPRKIVPLPFPSLFYDNDTSLEIKRIKNIQMLAIIEADHNAYDENTQQEIQKALRDIKLEGKGETQDGGDEQENDEEELLYDRIGTPKAGLGKWGSCIKIINPINLQIIDKISLELEEAALSVCACELEALHCLIVGTTTNMTLKNRNVPSASLRVYTYDINYKLNLLHITPIEDQPYCFCPFNGRVIVSVGNKLRIYALGKKKLLKKCEYKDIPEAIVSIKVSGDRIFASDIRESVLIFFYDSNQNLIRLISDDIIPRWITCSEILDHHTIIAADKFDSVFILRVPEEAKQEEYGIANKCWYGGEVINSSTKNRKVSTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PS60</accession>
    <name>V7PS60_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-exporting diphosphatase</fullName>
            <ecNumber evidence="2">7.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_01667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PS60"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:diphosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="K(+)-INSENSITIVE PYROPHOSPHATE-ENERGIZED PROTON PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB61860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="657" mass="70564" checksum="8F858931C45C375B" modified="2014-02-19" version="1">MKVSKAATYSYNKTLVTCFRSGTVSAIVNVSLVIFGISLLLLIVNILYPTISFTKYPTMIVGYGFGSSLVAMLYQLAGGIYTKAADIGADLVGKIEKNIPEDDARNPAVIADLVGDNVGDCAGQCADLFESISAEIIASMILGGALCENNIISDSICSYFVLFPLFIHSMDLFVSTIGSYLVYTKKDNLLLGGGKKSFEKNNFEKNNLSLNLNEITSENLEDPLKIMLKAYFITCAFSILGFSLLCKFLFSSVGSVTNIEDGNYNTTKGNAWIYFSICGIIGMTCSYLFVISTRYYTDSSYPKVKKIAHASLSGPATNIIAGLYVGLESTFFPIIIICISLLSSYYLGIQSNIKNGNDVINGLYGTSIATMGMLSTSVFILSMSNFGPIADNAGGIAEMSKQPEYVRTITDKLDVVGNVTKANTKGYSVGSAALACFLLFSAFLSEVSDISGTTFATVDIALPEVFIGGILGSAIVFLFAGWSLDAVGNTAEEVLKEVRRQFNEHPGILSYNEKPDYHKCVYIISKRALSETFKPGMLGILAPIIIGILFKFIGILQNNKLLGAQVMASFIMFSTSTGILMALFLNNSGGAWDNAKKYIETGIYGGKNSPAHISSVIGDTVGDPCKDTAGPSIHVLIKLISTITMVITPLIASRPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PS93</accession>
    <name>V7PS93_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PS93"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB61915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="375" mass="43931" checksum="37A95AF79D145EA2" modified="2014-02-19" version="1">MKIIKKKINLLYSNMNNNVNKNIFKRIISTIEKNRKEETNKLVKLSGIISNYNELKYFNLKKKKKKSYITILNNSNIINEINQVNKDIEQVFARPDKNDSTNLLSANFQKNESTNKLNLQSVTNEKERKKTNAYKESYYDTNINSEKNMNSQEKNSNIYKKSESPNFEISNKIEREVSKDMLNSNLKNDVDKMDSHLSDTNSLEKNEKDIHANSEYYNAKTIGHKYVSFSGENDIIFYTNSETLSDEEQFGNIKNSKDEKEANSNSKNISRLRNINVINNKVSELNYNNYIGNNDYIGYRDFENEHNNFPNYINSVCNKKSTYNYNNYEYNNMKNNVRNPIMVYSEIDDVEETSNYPIMPNINLGEQIFSTTVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT61</accession>
    <name>V7PT61_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT61"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47455">
        <property type="entry name" value="ADENYLYL CYCLASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47455:SF1">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="297"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="857" mass="99913" checksum="E00E3D6AAE9F3970" modified="2014-02-19" version="1">MVIWPLNAKMKKKSKKKKKETKLVVKKGIEIGTQKSGTNSNEINSSEINSSEINNSEKNVNERDADEMKIKRMHQIRRMSLLALGCCMNIHKFLNKFPTPIENKYLKVHIAITYGKVNFLQVGNILNKRDYILSGKPLEEIGLGESLAKDGETVISYSFYKNIKDKIEIKETCKKKYYLLIGIKEKLDINKLKENCYEQDENFIKNNNDKKNVNVCKNFDLLLKSFIPDIVYRKLSIGYNIFFNETRKVTIIFVSVKDVDTSTMTGIYSTHSIMKLTQKAVFTMEGTINKFIFDDKGILILIMFGLPPLYHSDDSIRALLTCFRLIDGLKSLKLNGSIGVSTGKIWCGIVGNKIRKEYTALGDSVNIAARLCCKAGNKEIYVDENTYNNCKHFIIFQSLISIKVKGKNKSIKIYSPIGTINKKGNNIDYNDLFILDYFTDKELLDNEMAESLDSAKEIEYDQKKWEKKNGKKSGKKGGKKSGKNDDDDDSDGDSDDDKLANGYEEVTDFNFVNNNFLLIYYKHKFKDRINDLLNRKDCLYYLKTNKETQNNSDKNKKNIYNEEQCICNNNLNSNCFKCNKIYSLSPYYFLKRELYIDYKTHTGPLFIHEYYDPLFFYFKEIYNIGGVLFLEGNEHLGIFEFIKLIKKKLKNFKIFNIGNMPNSLYINITNSLLPWKMLCNDLTSMWKLCNTRKKYLYFTNVDNYNILKEITHPSYHWFLKCMSNIIDDLYIPDTCLKKETKKINKIFDTKTINNITQIESLNGTHYYENRKNGRTFCNKLVKNMRKFFFNSSLEIQNDDQHKNKSNILSNNTNCVINNKKKKKKGKKKKKKKKKKLKEYKMKILMIQSCILPLLLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT70</accession>
    <name>V7PT70_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_01235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT70"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="374"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB61323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="648" mass="74911" checksum="E6A428C29AA67DCB" modified="2014-02-19" version="1">MGNCMAFINYSKLKKKKNTFTNLDLYLEDAYDSDSSDPYKKKIRKNKINNNTNVNNSNGITTSNDINNSDDQECNHNTKGNIPLSYENNEIENSVQHDNNNNSENELNEKGTNDNNNTENDKNKQSCKSINSQTYSDSISCNCEMNKQNQLCDKNVTPTNITTIISPNVPKKKPKQNVLNIKYSNMLLSDIRDTDIIVTFLFSLFLYFNANNIVDMLDRNKRERYELKNPLNINHDVIKFPTFPKEIIDNFLKNDFTLLKKYIKNKCNKLKKKYKTNLENVNNEKDEKSGKKNFKYELKIKKEKCSFSKIVESVDRNESTYRDITEVLYDQNIPDIKITFVVMGAYCFYQKNMKPFQDKNTFFYKSPSYSCDAEISVACKKGRKLDCPNQDDFTIIQTNEWILIMVFDGHGPSGHDISNFSHVVLPLIFSYNIERIFENPVRTMKTIFYMINCYLVNYSYCINNNINPININFIDYNLSGTTCTIILYNFLTKKIYSAHTGDSRAVMGKHDAKTNTYRAYNITEDHKPSLKLEKDRIQAFGGEVKKLQGDVSYRVFVKNEMYPGLAMSRAIGDITSSFIGVTCEPTIKIFDKSDEDKFIIVATDGIWEFISSEECVQMVSRKRKKKVHVAMGMSLKTSTIIYNLHLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT71</accession>
    <name>V7PT71_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_00474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT71"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="209"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="422"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB62791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1049" mass="125187" checksum="9F8BE9B39AA22BCF" modified="2014-02-19" version="1">MFFAKQKKKDKKENLTICHRRLGIFKKKLYKNNHQLIYISLSGHVYTSPDYREIADFDNDILTKLKISKTGECSSINNIKFVYETVNDLNKIDKFIHDEKNFEYYYIPPSIIRKYNEIKIYELYDEQIECLRNAFENEYIESNLNDKKDDIIYDATHVQDINEILNSEFFSAFENFGEKGEMVKCLDSNVMPEHVQEKNMNETQIKNIQNDKEFYKNFLFSMPTGMGKTLIYDIIIIRFILYKGYRVILTLPTVSLINEKYDYYEMLLGNSTVSLNIKKFNSFNFTGYSYSLSTDIALCTYEQANIIINIIIKNNLKSNFIFIIDEIHYINDLQRGFFIESLLTKIKYAQKNYNHIFNLRTYGFSATFSNIDHIGKWLEAKIRVSSKKTQKIKYLYKIKNVMYKDIEQKYIERTLDMPYVLDPDHLGYILSEELILKRNVLIFCSTKKQSEKVASFISNVISYYLKNNYFNISIELLEKRKKLINQLNEIKDININILEIEKLIINGIFYHHSELGKNEKDIIENALRNNILFCLCCTTTLSVGVNFNVHTIIIRNIKIGISFLTKDQIIQISGRCGRLKKKNDENNNFTIKPLHSNNKQINDSFYNEIKKHELTNKNNYYIKDYDTNCDGKVIIFLNGKDDVEYLKMLFQDDGEKKTIKSTMENFDLCKFIIELIELNIIKTKKDIIYFFFLYALKFCKYDMETDQIKDKDFPEKYKENILLEIKQIFQYLFDNKLIIIPYEKEQNYYYYIFEKIYNVNLYKIENIFNFNFLNQYININIMIKSNLQEKICLFKNLCNHYKSNNILDQENEKCTIPFITILSIFKDTHINKNIFPNLFVQFIKYLFLININNKQNNFYVYDILEEDDDLTCSEISPYVHPAPTSLDFIFNYSIIHITYVKGFSPDTLLMIFVFCLGSDINLKINFEIYESALLQNNDQINALKIFKYLDLNLDILQKYKMRKNENFKEVSERFLKGEINIEEISQTFEWVKIKRFYFSLIIYDIFNTDFYTVSRKYKLKTKELKNLYIKSCYNLSFNCKVIRNFKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTX8</accession>
    <name>V7PTX8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTX8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="211" mass="24510" checksum="B95B91A162761F4F" modified="2014-02-19" version="1">MPIFCLLINEKKEIISSSYNCTNESKNGCRHCEIIAIDKYIYGKNYEKMKNKNLIKCFNNNTNSINKSLSNYFSELKNIDKEFEDNKENTNCTKEHSINFEQIQKEITKKIQKLKKFTIVVTCEPCIMCVYALKLVGIQDIYFCCLNERFGGCGSVLSLHQVYENMNVHYIECNDCTNKSINLMKLFYKSGNPSAPDEKRKRPLAEISLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTY0</accession>
    <name>V7PTY0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_00651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTY0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB63056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="799" mass="92169" checksum="EADABB0FC8829D5A" modified="2014-02-19" version="1">MEVYIQMIGWHKLAIPSSLRLFVNGEFTLINCGENNQRFLNEHKMHIARIKNICFTKISPETIGGLIGLLLTIDNISDNSISIYGPKPIERIINNFTSSFAKIKNLKITIHEFSDNNIFPIILKGNVIITPILLNKKNVITTKHETDTIQNCEQTVLDKRKKMNEVSNTHDNELNNVYKNKNGEIGENLSPKETNSNYLKKRKLNVPEIEHEEAYESKTEIVNDNSDNGKIEKYKEDLDRDSNKIDNTNNNITNSTEIEKNSSMKQCIFYLIECPQTIGKFHVEKAQKLNIPPGKYYGMLKSGKSVTINNKIINPEDVCDKNIDGKKSLVIDLSDTEYIDCVIGEIKNKEHFYLNNLEYIFHLSDEKILSNKTYKDYFLKLKNIKNIKCNQSNSSLKICPFISSSSLTNILSKLMPNIFLKYKADDPIYELSSKTLNNYSDEKGSNSFKNTNNDSNSILNVNFKNEVECKNADNSFTNEDGIASFEENTNKNYNQKVINSNENKEEYTTYLSYNTLTKFVLHPFHKINICTDEMLTDLYPSTFNSSKISNFTHENDNLMKPIWDFNKKLNDNATMLPSFYFLGTGCSIPSAFRNVSGIILNIQKDFSVILDFGEGSLYQLYWISKSWIQFTESIKSIKVIFISHAHADHHVGIYYFLYIRKMIFPNLDPPLILIPKTLKSWMNLFNELFLDIEMRIIYNENDLEIKEIISEDNFLTLHLFKVNHIKESYGIKIESKDIGSIVYSADTRPCDNVKRFAKDCNILIHEATFDDELLVEAINKKHSTIHEAMQISKIMKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTZ3</accession>
    <name>V7PTZ3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="11"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1308" mass="151646" checksum="1C42348E4E0BAD10" modified="2014-02-19" version="1">MDLVKYLDKNEQIRNICILAHVDHGKTTLVDNLISSNKIISEKNIGKVKYMDNREDEQKRQITMKSSSILLECTYNKNYVTEMFSNITISAEKNINENDETNMPTEKYANPQNEKTKNGDNPTSISQKENNEEKDKITNNSMDENMYLINIIDTPGHVDFSSEVSTCVRICDGALILIDCIEGLCSQTKIVLRQTWKEMVKCILVINKIDKLITNKNMDSMDAYEHINNIIENVNAYIYQLYMEQNMDNEDTNNTIELEKYTFSTLKGNVLLCSSIHCWCVDINIFTYLFCKKMNIDINNCNKIKKYMWNRYYFNIKEKKILKIPNDTNILPSSGGTNTVKKKKKNLFSLVVLDFLWRIYDITITNRDDEKIKKLCTELNISDQFLQNSKFKQNNNENNVFILTTIMSNFLSLSRSIFNACIEIFPSSKNISESRLFKIYPSLYNNPIYKNMLNCALDPSFTIIYISKNICANLQNNTIVGFKDFYGQNTFLSICKIYSGTLYENMILYVCGKNIQTRIKKIYICMGGDLLPIKQAYAGNIVAIYLSIENEHPYNFNNVPTDYNINNSTYENSDQKYGIKNEIIDKSECTTSYEYNKIKDGVKNSDIIYSQENENITDPNGQWDLQYLSNTVINLIKNKKNNKEHNIFLMNNNDGIFLNKNITLSNKKNVDSFILSYSDTCSTILHTIIEPKNIQDMNKFLRGLILLYTCDTSIDIDFNQRGEYILKFCGEIHMQKCLSDFVNIYSNIEIKTSDTNISIREGISDYNIKVKKKKNIVHDNMKQLHSYYEAVQKTIPSKQNEDNNITTENGKEKFKNLLNTDNTNINKGYGSPQNIHSNNNDDALISSTPFKHIHIEKDNTFLNTLFNYSNNIISTKLNNNSFYIFLSVLNMPENMIHFFDKHYSSIQTILENRGISSTFLNYSKNTFSGKNEDFMYKQCLMNLEKCINDIFFSDNFNCETFTGENEPPLDETKKAETEVHQNSYFENSEHKENNNGFVQNSKKTEPITKDNYQTNFLKKNKIYQLQLWDICVQNGSITLLCIKKYLNKKKDNNEYIYDNIITNEEYKNAINQRSLIDTYISENNSDINIYLNNLCLGFKLASKYGPIAQEPIRGVIFIIEGLIIDEKCTDTPFEYSNLKRETVEEEGDANGSTGSDKDEENKINTGNIIGLMKEACLTSMQQSKLRIFEPMLRLNLTCESNVLGKVYNVLLKRRCSILSEEIKDGYFLYFIDAYLPLFNSFKLAEELRSKCSGNVIYDIQFSHWNKLDEDIFLLNDSSAIIYDEDFDTKVTYNTSTEIVNYIKRAKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTZ5</accession>
    <name>V7PTZ5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_00660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTZ5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002771">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB63071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="104" mass="12450" checksum="3445A5198E16552D" modified="2014-02-19" version="1">MALSTRKKKKPRNTINSKFLKIRKRKRDFDEVYNDYHTKPALPYDVDKKGCGQFKCYACDIYFINDDAMKQHEKTKKHKRRVKLMANEKPYTYKDALRAAEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUY3</accession>
    <name>V7PUY3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_01718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="963"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="808"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="967"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB61943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1829" mass="209237" checksum="ACDBB0FBA140ED0C" modified="2014-02-19" version="1">MHKMTVANNYHDHSFFYLNNRTMLEEELTYFQSNDLSPEPTATIDNKNLGDYKTSADTFNSNENNKNDVLMNATLNGIKINKVPTSSSVVNNNNMDISDRQNDTNIIDKKANKRNNELGKNGKVVINSNNTKDNINSLNKIKKNKINNTNNNNLSNNKNGININSKNSSKNNISNYDNINGMTDKKKRNNSVNSVKRETLDEGIECNNKRLDNNGNCNYYNNTHEKVAHFFDDNNRRNNNLQFSQKCARDMANEQNSNVVLHNNEKGDHKNINKRREDKNMNMNLLNNSIIESSSCNMYNEEDFKNFDSSINNFNYVHSINNKLDLKDLNNIMKYSNNLDKNKQLYGYNDSYKVCCTKGNNNEGMKMSENNLMHNYSYTDCYKNDNIIENSHRKNETNGTNINTCSTGNNIYKNIEKNNNNNNSRGFNHNCLNSSDDNICNNKNCEKNADNNINENNSTNNDGIGNCDNRKHMEENGKNDHGSEGNDDKGDNKNKNKNTNNSKNKGNNKSNKNKNGNKKNKKNGNQNVKNNPNNNGEDKTDQKNDTPNGKYLHGNTNMTNNKTLKHNTETNNISVTPSNKSAIGNSGSKKNGNNLINLIISDKYSNVVPASTTNTNNNHGNISDNCNEIFEKNKCACIESNSILFQDRDIKYGEKNERIIMCDNDNKVTNAIDENKSNDIVNLNNTINLLKNNIYNAFNDTFNEKTTESIYFSKKTSNNDVDRIIENTEMEKKPGMNQINQNILQNKFGLNDERENNSMTNNTYTSTSINDSSITQLHNGMKLSLIKTYDINKSVDNSIANNSGLNINMSNNTLNTTNQSTEMNENTSTRFSQNNSLNQHKETNINYNRYNNEKNAKENSNSLNLRKIGNNNMCVERPVILNNSQMLQAFMQGRLCLSCDSLDHPMPLCPNNSFVCPNCHNISHRGNDCPMKCRFCLKYHIGISIMDCLKKARIQNEKKLLNKGKNDINNNSNENNNKIGKNNKNNNEKTNVGPRFDITTRPDNSYGRSVYVSNLSDEITNIQLRDAINNQLDNGFVVNIDRQNGYAFVELSNLNSTFQLVQRSININYKKLKIQFKKTGQFLIPDNLSFNSNNVSQPFNLNNNENTQNKLNKSCSNAHVSNKNSSTTNNASNLGTIQNNFISNHIHFDFSTQIKDSHMKTNANIVNNITQNDTNNITVNNSSNNITNPGNNNCLLHLDNMEKENGCSSKFYYETQRKSQLQQFNQTNNLKKYKEKDINNLCNNIGGNCNGNIIDAHFSSKVFENIKQTAQLNERNEGGNNLLCNNSNKNIKFEKIGINNYCNKNGNIVDSCSNYQIKDLSNYYNMNKNNGKSDNLIKQNNLYDFMSFEDENILNDYLKKKNINRNNNISPMDIANMEERNNHNFNDNMFLKFINHITNDQNKLNNTIINERTKTTNSTINNNLDTLLNSHLFNNRSLLLKENNNNNYNKTIEDNNVPDLSSSNIYLKNDNNLTEYNSSTDDNNMFQKYIHENNKLMDSSTTLDIKSIIDNAIEINHGTIGSDEMNFTSTINSNSASSNNSGCSYSNGIHKADTREYFADENSYNMTYMCSNNDHNNLTKNNRRSIYINNNNNIQNFKREIEQDKLFNQTNFSFHTFEDDKNCNGEKGINQFFWKECNNNNSNSNCGSGNNDGDILSQGQTGYKNICNDILYRTNPIYDIYKKVNSIKNNSPSIDNCNQRACEGNYNFSNGVENASSNNFDNVNYDFKTQNNDILFNNINNEKTEDIHKLNNDTIHYNQHEQINFTDIDINKIKSIFNNQNMEMLNNNSYMKNMKYKEIDAIEKDLESHIKVLWNLRKIKLGESYNNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUY5</accession>
    <name>V7PUY5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L17, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_01013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUY5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764471" evidence="4">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB62442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="133" mass="15690" checksum="6CEDAC069FAF119E" modified="2014-02-19" version="1">MKTCILLFFLCKNILAYVLNRNAPINFTINKNTVRNIINKRDSLLLAHTNKNFRKLGRDRSQRRALLRALTTSVLRHGKIITTEAKAKEARRKVDRIITYAKKHFNNKQYSYRLIANYIYDRELALNIVKQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUY6</accession>
    <name>V7PUY6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUY6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="118" mass="13926" checksum="58CB4506A52209B1" modified="2014-02-19" version="1">MKYTAFKNSLRFASKFCQNNNYKLYMNSVPQFSTYAYGKYLKTNPLTNRLDDLLKKNSNLISIISLNGLDDLITQSSKIESVSIADWLLNLVEEYQCMIKLHHSRKMCTYYERIQYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUY9</accession>
    <name>V7PUY9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CKK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUY9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014797">
        <property type="entry name" value="CKK_CAMSAP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01051">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51508">
        <property type="entry name" value="CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="CKK" evidence="3">
        <location>
            <begin position="739"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="848" mass="100609" checksum="4D603ECCF79D5570" modified="2014-02-19" version="1">MNKSEENGQTQKNTAYKTNKKKLCKNIMNEEHPFYVNYDILVKNYKNEKNYIDLNLEINYNLEEIEENNENIKKCIFIPNSKNKGNLCEQKARSKNEKINNQHETNYNIDAKNNFISSKHKKKNNNPNCENRESSRTNQTDHSVSSGEERKRNRDKSKCKSNIKNKNNHESYSSDSNGTYCSDLSENYSEIEKKSMNFSQRITYDDIIPNKINLYDTTLDLNSYMNNKNKNKDQNDVDYISYGVNKLKRAISNNSSLLFADNNTENFNYTHNNNSSSNDNRSDTNHTEIYSPNIFSKQHKYAFLDQLYCSKEEERNNNPSIELARERSSPIRLQFNKKDKILNRRKSEDDILNKYEKIIKIMKYLRRIKTRHPEIETIVSILSNNIKNVTFNCEKMFSSRRELNDFLKKIYIYQIFLLKKVVFKKNYSPKNNYSKICNSKNPSTQKVSFVNINQSHLRDYSEIPDDTKRDSNYLLYYLSKNRSFNIPNNILYENSNVNKDHINKNRQNSVDMLGNIHKYIDKKSTKNIEDKTYYPCINEKDRKNNKNKKYNNKSSDNSDDEKNQNYKRYDNKIKENKKKNHKNNKHNINSDNALDKIEQCQEKRDIFSKPRKNHILNIKNELTNTREIYTNDDNNSNTFVNATLNECKPNKNYLKRIDNAEDRHIMDDPYAKGESENSNFNITQKRGQFEKKYMVLKKELNMNALNLENKCAPIRKNISENEKFPNNSIDKDKKTYVLYYDVNKEINTISNRDSVTHALKTTLLNKPQNFAALQNFLFKIEVELVEYKHFILLITKNFKKLNLEALYGLNDFSVFEKVCEMLFLFCMQTICICIFVWHFIHNIAYSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUZ0</accession>
    <name>V7PUZ0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUZ0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="114" mass="13113" checksum="F521B5354946144E" modified="2014-02-19" version="1">MKYTAFKNSLRFASKFCQNNNYKLYMNSVPQFSTYAYGKYLKTNPLTNRLDDLLKKNSNLISIISLNGLDDLITQSSKIESVSIADWLLNLVEEYQSVGFPLGALDSQHYFIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUZ2</accession>
    <name>V7PUZ2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_01720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUZ2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="144"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB61953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26099" checksum="AEC4C651BD847438" modified="2014-02-19" version="1">MSKKYISENNPNISKSALYIASTSIAELTACIVRLPFEIIKQKMQVSSEASVKNIINGVLKMQGAQSFLLRSYLVIIIREIPFDCIQYFIWETLKEKGQKCNKKIKLNIKDEIISNLQKLKINIIKKNINYFIFKDFREFYEKHPVIMSSLSGGIAGATAGFLTTPIDVIKSKHIIYGRSYIETIKEISKGGYLSFYKGCLFRTCYLFFGGLIFFGALRLFSFKKDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWA1</accession>
    <name>V7PWA1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1367"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1407"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1528" mass="184018" checksum="FDAF732B23B73751" modified="2014-02-19" version="1">MIEKMIEYTLNISKEIKKKKEKKQYDNIVSSALDYYKNVNCSEYKEKHNGSNISCHTSIESVDPKKGENNKSDKKSENNKSDKNNEQDESQDGGIFLIEKDLCLRNDMLKENILTKLKININEYLYNVKDKIYNEILFAVDKKKLLNKYIYELQCNNFEVLKNIFFLLNNEYNDYTFNEIFHTLLLCFNKKDEQNILIIIYIFITLLNQNNINKSYTHILDALINILNIDQCPLPLYQKDDNTRLFDHKPMVIKNQFISEYCRYFLFLFFFYLMRLISNYQMSIHFDKIIQVCLVGLFDNCYEINLLIMNFIEEIINKIEECYINYHYIISTSLLKCLCNKNSKIKIKCMHTLVKIIKNNNNNTQNYKIIEMLIGYKDPNIVPIKCFYDNNYVNINYLCLLYNDKSIKVKYHFYSFIFIILYEFIDYNDFSTFLLPYLFSACFDNYKIFRFLSFIYIQVLLKRKQFGNISTDSASYNNNFQKNMNEEEIYDFFPEWSYKTPFTLPLPLTEYYFPQTYNNPFIIKKDYYKINLHIYDSNNNIKETTNNFYFDGNETYPVCEERDNNKKIKYDNFEIEKCVTNKINDYDEYQHYEKTINKFINSHPYISNILKENKIKDIDITSNKMNKEAKELSFTLLNTYFKHLYKKEDDETNKSQFLESSKIILLIFYFIEDNVTEHIPQFFSYLFNSFDKKIDQQQLNIYINSLYLIGSYVNPSNYYLFIENYLNNTTENNYKHITLICLYILYFTFLGAIETYNNIKKRGLSQSDIHPSFIMIITKVTNLFFLIITRDEYPEKYILILQIIYLLFKNEEVYTKIEEKTMTELIILLYIIFKKTTNTRINLPKEKDHMCIYKNFYISIDIFDLHFYLTRLRSFKKFEDINFDKESMNIQLSSETIYQVFKLFDKNINHQKIILDMLSDDILYNPYYVYYLIKYIIKKQNFFYDSNFSLFLCNIIIKILNINQNEQNIIKILLYNEKLELNDIHQETMKKNKKKVRHVFLEYLSTIFLLFIFKNINIYESFDNIIDTCKIIYYLLSEIKNPYSFLYFVKQTCLVHKLLDILECKQVKSLYFCKYIINNIYLEYGKYINNDGDCRYLDNINIKKKIEIKNRVNYEVNILYYFISCCIYLIYYKSLCCISIISNYCTEKNNEIKLNNFFNNIFQNTHKRLLNVLKIGEKNNNTFLNTYKHNINEILKNKNFMELFLLRNNVLKENEYNNLILSIHIYFRHTYDFLQNINTFILNPVIINYFYGVSKEHIYAENENENENKNKDENEDENEDENENENENKNEKLNDNAKDTIIESTHKTNLINTIESYYISDNINDIALIQYDTNNFCTYLNNHDIAFILLRHDIYNIPFRILENKSIIILLYSYILFFSDNFFIPNLTKNTNTPVLSNLNLGLVDDFFLNSSNMNTTYVMGIFNVLILIYLENENTLKDSLKKKKRFTYFEKLNNLDKTTFSNILNNIISSYENQDTEQKSLRNCINFLLNNLSSPYLDILTNLRDTYTRTKHVKRLDVCNYIINTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWB0</accession>
    <name>V7PWB0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_01005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWB0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB62433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="68202" checksum="9399F60392E0C77E" modified="2014-02-19" version="1">MCVHLTLTQAFENNLNNYYHHVEKKVENDKTSKKSFFSSFFKSEKKREGEIKGKDMEEEEEVEESEEELGKLKNDDNFFIFDDKIKIKKEENKLRYECINNENSYNNNINSCINIEKENGIKYVRGIYVYGSVGRGKTYFLNLVFDRIKIGKLKIHYHNFMQKIHKDFHEEKLNNSEQPIKNISIKMSKKYKLIFIDEFQIVHISDAMLIKSLFKHLFYQGTILICSSNRNPLHLYHNGLNRERFIPFIKLLFKFNYIYEINNYHDFRLRNSNPDNNIYNVPSKKFEEIKKLCVNIYMDTYKKNIDYVKNVEKINHQILVSNYKKYIIPYNINNYAIFSFKDLCCQNSSIDEYNAISKENNTIFIYDIEKMNEEVNGNEMRRFILLIDILYEKNTRVFFFSNIPIFQIFQTNSIISDFQNLIEKMKNKFDKFNHFKNHFDKQLKSGTFNRLIFSNIVHSFGISQEICNKLFDAINYNINKEYIPIEYLRNILCFHIINYENNIKESLNYFEDSNVELKPIPYLLFDENDIDTSQENAFASMRTLSRIKHMCTIEYLEKHKKLYENEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWC2</accession>
    <name>V7PWC2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWC2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="114" mass="13301" checksum="AA600D1EC85ADC44" modified="2014-02-19" version="1">MKYTAFKNSLRFASKFCQNNNYKLYMNSVPQFSTYAYGKYLKTNPLTNRLDDLLKKNSNLISIISLNGLDDLITQSSKIESVSIADWLLNLVEEYQCNLSLEIWQWLVYLHSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWD4</accession>
    <name>V7PWD4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rhoptry protein ROP14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_00203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipase maturation factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWD4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057433">
        <property type="entry name" value="LMF1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057434">
        <property type="entry name" value="LMF1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="LIPASE MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463:SF10">
        <property type="entry name" value="LIPASE MATURATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25179">
        <property type="entry name" value="LMF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase maturation factor 1/2 N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase maturation factor 1/2 C-terminal" evidence="10">
        <location>
            <begin position="511"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="692"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB63445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="978" mass="116446" checksum="F521C83B248FD435" modified="2014-02-19" version="1">MVLSAGALLLNCINVISVLIIYILLQSIYSIGNVWFNYSFEIELLELVFLCLFIVPLTQNSVKNKYSTTFLIKYVCRFFVFKVLLGTSLIRFRNTDVWGKLEGKYYLYETQPLPTIISYFFHSYKFLSKCDNLFCILCECVFSFFLLFPIRSFRIIGGTLIFFYCILNFLNQNSYLFYFLLLAPLMYCFDDKILLHFFFKSKKNKIINIIIDKIKNKHKSRRYFKSFDIFYFMGLNEDEIYNMYDSYFNIDYINSQNGLNITQKNNIQDSDEEDEKGNGEYDYNDEEKVFLKYDNSQKNGIYFNNKKKYNNNNNNNFFQDIKKDIYNIYNWIFKQKGLSYILISYNISKDVFINIVGSLVIFIFNCLAVCLIKIYNNIDSHEDGIQMGISILFITYFSLLLIYSLYLFLFTKNYIAHFISQISLLLSTVLIYSYKIFIDGFSDKYYSFLFLFQLLFLFILSAFYLNNKKFIYKYLSQYFYFILFAHFIYSFLQNILSPNQIMNETINNFELMNIYGSFGQINKTRHEIIIQGTNTKKIDNNTIWENIEFNCKPDNNIKNLCFPIKFIYGFIPIIYIDRLDWHFNSLGYQNNKNILENKWFKTFLIKLSQNDKQINSLLYKNPLNFNDNNNLETTISLKVLNAVYNFSHKKGSEWWDVSSSDTIIGPKDIPYKELDTKSKKKNKLTASLISFDNKYNDNIKNEEKKNEEKKETNYMLRQNIRDIQTKYQKAIEKNHEKKKKNYLNKIKKNNQNNNQDFLASQINKQIRRHILLPQISKNKNVYLKNGIMNNKVNNILNHYSPSLLKIQTASEFYDPIKNIKYYDHSGKFGNKKYKYYDHSGKFGNKKYKYYDHSGKFGNKKYKFYKPNIEKNTIEENVNYFKDNLNDQNLEIADTLKKTIDNAINSSYANFDALNYYSDKINKLGMLENYNDQNKLIPNYIFQENTLMNHPQNNANDDGVYLIEAISENIDKDGIQNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWD5</accession>
    <name>V7PWD5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_00551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWD5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764485" evidence="5">
        <location>
            <begin position="27"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB62927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="114" mass="13634" checksum="B7A18F094A6A9941" modified="2014-02-19" version="1">MNGKNILKHFFFFPLFFFFLILSVRAKMLKEAEATATEELKIFRAKEKERLTKGHKEKSTAEDEIVTKIEQNTKDEIKRYKDLFKKNKDQVAQFVYDKVFKVDIDIPDCVQKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWD6</accession>
    <name>V7PWD6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWD6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="148" mass="17504" checksum="9974EA2E678ED673" modified="2014-02-19" version="1">MNDENQRKEKLTIKLRCEYYAVLFSQSSKLLNEYINFRNRLILELAINVNGLINSIHPNIIQRLNEDEKKELQRYCENIRNERTKSKLQNKHIVGLLNDLIIEDLNYDGIEDDKRGRNVFYAAGMKVSVFEDKAVDLQKCEWAKILKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PA11</accession>
    <name>V7PA11_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-protein ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PA11"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="81961" checksum="7B2B01EF10A2524E" modified="2014-02-19" version="1">MYSNYFSLPNLYSYFVNENEEIDKTEKNKIKKIKKNIILFRSYIFLTSKYLKSILANNLNKKKKEKEEIKDARNNFVNVPKIYFTTDNKIIIRIKNIRYNINELETYFNNLENFPYVDFYKTIKNKKIYYGSNHGLSLLYYYSSSLANHTGSILALGIRYMHGIGVEECCETASKLFIKLTNNILNSNNDGKMKFESIDLIKLNIPHYDKYNINNKKIKNIEMFLESSLHNNHAILTMIARRYLTGSDGIDQNYTKARMYLLKAEKFNNPEAISLLGYIYILGLGVKKDYNKAFNYFIKGKKLNDPLSYNGLGYMHFFGLGPMKKYMENGKKKKNQELAFYYFDIAAKNNLSIAQFNLGCLYLSGVGTSQSFQNAFYWFYKASNNGNILAAYMIGFMNYNGIIVSHNCNIALSLLAKVAEKNDFILNTTNKIIKYNESGRIRESMFLMAQLAETGNVQAQINLAHSLTTSNFALFLPSNNKSKYIYSSRYLSMAADNHHLKSVFTLGDYAYGGNGVYINVIQKNNLQHNKFYDLGNVECVYNSVGDITNECFRNKNVDKISKESKISQELNIYDNKIISKDFIDEQGIIFNDKWRFSYGYNFIFNQINYELAYKHYRAIISYYPNTTYAIKTISKACYNLGYMHYYGIGVEQNIDKSLIYFNSSIKIYSSHKIPSTILIFYIKMNIYFYKLKKKFNIFNKILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PA19</accession>
    <name>V7PA19_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PYST-C1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PA19"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006488">
        <property type="entry name" value="PYST-C1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006491">
        <property type="entry name" value="PYST_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01601">
        <property type="entry name" value="PYST-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01604">
        <property type="entry name" value="PYST-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09690">
        <property type="entry name" value="PYST-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004763852" description="PYST-C1-like N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PYST-C1-like N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="198" mass="23167" checksum="D8C7E29E97907F28" modified="2014-02-19" version="1">MNKRVYSLVCIALYAFLAGSIHCFDPKVSVAGYTSDIDTKKINGNNEADDIEYKHETQLKNNNPKDGAYDEDDKDNKEFNCFNIFKRDKKKKKKPIINDVPVTLPYNKIVLTYSNNESLPTVTMRMGQIQRRFIPKDQKHLEDVLKLQKIFEELYSNNDESLSKAPLKVSKELQDMFGKIPKFYSYYYLLKEKLEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBP6</accession>
    <name>V7PBP6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_05637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PBP6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="89"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB56167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="156" mass="18162" checksum="19B2E63FAFBD5C12" modified="2014-02-19" version="1">MCYIIFSLAKEKYYLMKDEIKYLNKDVDDLENSIDVVKKNTHKFNISNEEIENRTKSLKNIRAILNDVASDLTNTALSPNIYMMDDYNNIAINKQNDDLEVLAESAERLHNAAITINTELKDQQRLLDELENEMDNSNEKMNFVTKKISDYLQTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBR1</accession>
    <name>V7PBR1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acetyl-CoA acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_05653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PBR1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="196"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB56187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35098" checksum="F29373D28730416B" modified="2014-02-19" version="1">MNAKTHLINNLCCSGLDSVTLGYDLIKSGKDVCVVGSMESMSQSSFFLKKLRTETCKLGNVTFNDSIIHDGYEYISNNKELKKNNNMELFCKKHKIPRIDLDNYVINSYKRAANAYSENLIPQEIFPLIIQKKKNTLEYEKIVIDTDEIYKKCNIDNICNLSNESIITNYNIAPFADGACSIVLMSEDKINELGLNPLVEIVAYDNASVQPCDSPLSISYSILKCLKKINKSFVDYYEINESSALDVIFNVKNLGIDMSNVNINGGALSLGHPTAVSGSRILISLITILKNFDMKFGCASINNYLGSATSVVVENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>V7PC11</accession>
    <name>V7PC11_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_05736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PC11"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB56302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="659" mass="79723" checksum="23BC8E1B1A705908" modified="2014-02-19" version="1">MHGRKANNYKEEYGKLEKVKELIPVVNDLIIKKKTSKYEKKYIQMSSTILRKCPYIQTLWNYRKEYFEFIKDEYLNRNEKIHNDPKGDIEEKKSEEFKNELKEMMENENSMIEDILVKFSKCNELWFHKLWIIKYCIKNDLINLEHLLNELEYCKKSLYIDDRNYHCWNYRSYIISCINIYKKKTNENLPTNMGSVEINEDDKNKHVEQNVNNFNVQTSNCELSKLLIERNFSNFSAWFLKYSLKEELININEELELIKNAIFTDPSDQSLWEYYRWFLFKKGKYEEEIFFITLENNSLYIFFQNIVKINTDKSKCYDSQNEEICGKWDRQFIINNSGNKNLESYIYIFKVNENINLSNFSYLKLSICYYKYNIHTPQNINYEENVLQDLLIGYDHLIPNEKNQYNIIYEINFENFSKNSHFKLLLNYSKENNKEDQTLCKNNCVKPYTNLYKYINDTNIRLNLAKNVNFHLLNFELEQINELLCLESDCKYALFTKYEILKKLERFDELFEVIDKLKEIDNIRIEYYNDKESELRIQQKVYDYYRSSKIEDNDEILDLSGLNIENIIYPSLIEAFYIQKINLSNNILFESWSGKCTINFLYNLKELHLCNNKIKQLSTLMKNLYNLKLLEMLDVSNNELVKLDEELDKYEFDTPPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PC21</accession>
    <name>V7PC21_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_04929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PC21"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02619">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="388"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="692"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="810"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="717"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB57086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="965" mass="109635" checksum="F5CFB3A5311BA3B5" modified="2014-02-19" version="1">MLKNYKGLKITGQCNSSFFMFFVPYVYIDVDTKINQISIFSTKKKVNGTTNDVPTQLIEFKSENDNLQNQCAENKTFKIVIYLDNDVFYVKWKVYGPSTETESNTNVDVRKYRLKNIETPITSIQVHNVKRTSKNITIESKNYTINDDLPEKCEAIASDCFLHGNVDTEKCYKCALLYRDTPITDKCYDYLPNDYKESLKSDGLVTAQSEDEINYELIGHIDNVLEGIYNIDEDNNNNKELKKFEELDDEIKKDMLLYCKELKESDVSGTLEEYALGDVEDIFYNLIQLINNNTGVVISKLKNKLMNPAICLKDVNQWGEKKKGLVLPELSSNNFDNLNDKNDDTTINSKLDEKLEEEGFDGVIDLPLPHENEFEGYTTIEDFQYCNNEYCDRLKDNNSCISKIDVEEQGNCATSWLFASKFHLDTIGCMKGHENFSASALYVANCSKKDSKDKCLTGSNPLEFLNIIDENKFLPTTSNLPYSYKKVGEECPKTMDNWTNLWKDVKLLKHENNDKSLNANGYISYQSKDFKDNFSEYINLIKQEIQNKGSIIAYINSKDIISYDFNGSKIHKLCGSDTPDMAVNIIGYGKYINENNQVKSYWLVRNSWGKHWADEGNFKVDIETPENCEHNFIHTFATFNIYIPFVKKNIPSESEINLYYSKNSPDFYNNLYFKNLDAVDTNKDSIIEGQNEPAKVADSEETNQLTGDGQLTSQGGETKELPGPTEEKTPKEGGGSEEPSTDLQGKTQELKQQQQQQQQQEQQQLQSHPQPGPQPGPQPQPEPQPQTKVEGQEQVQEQVQVTDGVQAAGKQVDGAGNTGHLAGQEVQKETGTTGASSKEKGPLPPVNPSEGHQAGKVTEQQADQPSAQAQPANSITQLQAVKIEFMHILKQIKNGRVQMNLVKYGDELNMIDDRMCSRVHAINYEKKDECEKFCANHWNECQYEASPGYCLSKMYKSDDCYFCYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>V7PC22</accession>
    <name>V7PC22_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_05323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PC22"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="187"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="667"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB56974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="751" mass="90829" checksum="1DDD230640C2DAA0" modified="2014-02-19" version="1">MKWNGKDSVENIKSGSKDYIINDSYHEIGDSILHDDIDILKIYNDNVNNEHINLDKNILKGNGNNNTNAIKYENDRNYDIFLEKKVDKIKNENNNNNMEYKQLSFVKPFKLNKFSTNSRNKIKLILKEKNINEIVNIFKKKKLFLWLIKYSNLNQNYHHDINFPYIHKIYADFLFEKEQYEKAMNHYINTIEFLETATVIQKYLNLDLYEYLSIYLEKLHDLNIFNDEHTMILLSCYKREYKKKKIISFIKNNKNKINLNKAYKFLLNIGYYNVVLKFSKKNKDHLTYTSILIDKYENYQKCLKYIFKLDIQNICILLFKYGYKFIKYFPDLTISLLKKIIKKYDLNLTIFIPLFLDNNNFLFNFILKFLDKKEKNDLLIQKYETHNSKTNKNNESNQHHEGYTKDNLENEEKKQINNSDRIHNKKIEFDIFNDEYDYVLFITVMQILLQKFKQKENNSILTYNIDKLIKNNDKNITYLSVILLSIYNYNKGLLYVSNKMNKYDISFLFYTNKIINKFKSEYNQQLKLLKQNELDININIFQVLENKFNKNIFNSCLHLLKLNDYAYYNYIFYYLSILNDDKLFIKLIKIIQKKYSLSILNFISILQKYNKNYNCIKKILLTYINEIDQDINDKYEQILADKKELYKLNKKKYSYKYNFRIIDNTYCYICKETLSLPVIHFMCNHSYHYYCLNDTQTCILCRNKDNEKKLLKEKAKNAVTNFDEFFKFLQGSNDKFAFISNYLSYDTISTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PC23</accession>
    <name>V7PC23_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_05395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PC23"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000039">
        <property type="entry name" value="rRNA-processing protein FCF1 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB56545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="193" mass="22493" checksum="E99A43F4792FA4CF" modified="2014-02-19" version="1">MGKFKKTQKVLKLKRVINPNDNRLKKTNDKVIKKNDKKNEGKVKQIVPIDSNLFFNYNENLCPPYNIILDTNFINSSIQYKIDIIKGCSELLLAKCNIYVTDCVVAEMEKLGQRYSLALKLLKDPRYNRLTCTHKGTYADDCIVNRVTESRCYIIATNDRDLKIRLRKIPGVPILYAKNFKYKIERLPDNIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PC32</accession>
    <name>V7PC32_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M16 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_05758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF33">
        <property type="entry name" value="STROMAL PROCESSING PEPTIDASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="217"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB56327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1388" mass="163993" checksum="95315FBF1796DBFE" modified="2014-02-19" version="1">MYILNNENHVILPSNPISEEYKHCINPIDFNYEELHVYMEVNTGSVNEKKNQQGISHLCEHVSYMGSKKRKDIIDKNIRTNAYTDFHHIVFYISVSLNNEIYKENSLTDFKYDNFVKNIKEDDIENYDIYTVDEFNYKHSILSQCLDVMVDVLSGRDQFNKERITKEKKAIFSEYSIINTVEYKINSDIIKTLHKENRLSHRLPIGKLELLKRYEEKDVKEYFNLFFRPENVNLYVYGDINADIAQKIINSKFNNIKCTDLKKTDIEYLNILNDKNTLRSKNKNLPAVVHMYGSTPKNTSNANSYDKLIDTCNNNQQNSCNDKEVSQLISEDTSKMGELIDDNIADLVKFKNLKKENKNDIVTELKFRSYLQNKYAVNLEEEKSLNKPLEKNFKTQFEIFKYSLNNANINILLKEEIKSIRSMEDFKISIIKDIIFYCLSFRFNIHRNDLFNNIDINEYTNINEGSTIRTIEIKTNPQSIHKSINGLYKFIKSLIIYGFSKGEIENYKINEIDFDSIDEQNAEKNNTIDTTNNSNDGEKGSSSTSQNMKLGHSETCNEQNEEYILDTKMNEIYTDEIQKIIDYNSCNNVYMNEKREKKLKKQIFENITIEEINNFAKNYFQYLFNIFNEDTSLKPNCVIIHVPYANFNDLKKSDIKEYFYNNIYSEEQIPNYSINIQKQLLSPQYIYQNITENLHRSKYIDLIHQKQKNSSIFSYILNQIKRLEKPHGIHNTNCILKNLNTEPNFDLFKACYNIDHNDNKKIDTINELNNNEFPKSSNTNNFDQDIETTNENFHEDVKLLNLKNYVLSNKGKKEIENYQLLNGIKINLYKTQIDKKYVYLRLIIPHNDILRKKKNKLQNKSSNFDLLFSIICLFEGGEIENISRENVEIHCSNKSINIYIDINDEYFYIDIYTYNKYENINSAFSILNNIILQTKIEPSSLPRVVDKLKKDFFEYKNNLQSFLLGQTIYYLSDGAIGNQNFDIQDVEKITFETVQNVLNNLFTDLSLFELTIVGDISNRIHYYILHYLGTLKNRNMEAYKNLKETEQLKDISPLEKNAPLQQSTPNKNFETTHISNDLIKKKNENNLLDEYNLLCPFKNYEDKLKDDTYVYIKEKEEHAVFLLIGKSANHFGFLPNGVHISLYLIQYLKELLHHKENEHRKKTDDKKNNKNLDTTMIDSELESISKHINIKDCEGDTFQEIINRKAKLYIHPLFFSIVSYIIQYILNSKFFHHLREKKELTYDSSFEFINYDKYFAGFFTLLVQTNPQDLNIVKKEVLSAFHEFTRNYYNYSDYLIHNAKLSYLNKKNKDLKYFIDKISGMMLTHFPLKYKNKGLLKDNIILNKIQKIDILLVLFILFNQKKNYHISYGISAPENLWTNLYKNINKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PC33</accession>
    <name>V7PC33_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fam-a protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_05331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PC33"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB56984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25980" checksum="A17DF07D98C7D723" modified="2014-02-19" version="1">MNEAIMLLQYHATSIEDYSLLHKHDDGSSEYIKKHGNADIHKFIHKMPNPDSYDSIINILFNYDCTHKIGTSTVKEKVVREYTPNLVMVQQRYKNRDLSFQGYYYALSKKDQISNDTTVIALASANINDHNKADKKIYKNEILESANSFKTDIDSEEDIRKGKLKKMFVNLSGCLIIKKLNYIDIIHISSMNVNPIHSPNERIKKSIAKKLETFINLRYIFSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PC36</accession>
    <name>V7PC36_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PC36"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="206" mass="24173" checksum="D3DCF2B374C7D9B9" modified="2014-02-19" version="1">MAQNPWHITKLKELRTSKLEKIINKFQEENNHLMCIPKFKQVQNFLSTIQEDSELIINKKTFNVAHICCIAQLRPMYVDNVKDGIAVYLSNFMLKMNHDIEGFSVCFNSIKLKEKEPITLNNDPTVMFLKVTFKLLIIVLKENYKIKVKINTIEPSIMRMEIFGIIEAVISDENAKEFYYEGKSNTFVRHKTTYSINDIINFTIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PC57</accession>
    <name>V7PC57_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2301" mass="274987" checksum="2AB96AC387FF5605" modified="2014-02-19" version="1">MYNNIKSRSYNFLFLYKKLVSNFDNLYFENVLQDIYYFNLKSSEEKSVIFFFKSGKIGAYEKKYYIIPDIDSDFSELKDREKYNFINYNGWNIFQFRIKVIVEPILLNLVRINKRIARDLYECRFSKYLENQQKDKLDYFFYSNSGNSYKFSDIQVNSGYNFTELEVVNNGLIDLNISCYIYVNENPESKKIVLEKKNKGTYYYEEFFDPAFADSLYENRSKMRYNMESGKIKVDKKDKNSEKKKKKKNKKKCLCPIYIYPQNFVLSYKKPKKIYIVFKPKDKHKNYKNYHFVMIIKNICKGSDVNIENLLEIDKKQEEKEINGFPLVCVRENKIIDNKKWNELFGNNFSRYEYSSSSLCKSYSSYSEINEEMIKKKQKKNQKIFNKKNKTTNFIGMYINIYANIIEPSINIKSEKLSKCFMLNPLFLYKTSFTIKNQNDFYISYLFENVIKLSDSSRCNIKVCSNEIVKDLQKDPQNALLEYKEEEKIVSSSEKMENKQRDEDSYKNDEDAQRLSSVSGFIENGICYYDYYAVLNEIKLINEKKKNIKYIKKNVIRKKTNKDNSNTTNRNETSNDKPFDCKQNLVFNDGDEIANKKCVKSDMNNKKEDTITLGEKEDLYYNLNKKFIKYFYNKGNNDNVQVYVLIKNVVSPKQIDIMNKLEVEKKLRYKERRKIREQNLYRDEKIKDRNENHLKTKNEGYYLLPHEKRKIVLYFLVNKYGYHKININMSFYMGNYNIKKEIKCSILTKSKGISINQTDFVFENSYSHYGFCNIVKINNLDKDLKLIRLEDLYKNKSISNTDDKSNKDNDISNNNKYGFITLYTFYCNVFNSVKKVNKNELIKKSDLIYNFKNSFYKIIDEKMDKNGIKKENDFYNCNKCKCLFKYNSCIDYLSDIFSDFSKEFNIFYNYLNGEKYIIHNMEKYKSINLEDNDEKISLNTNEFNKNFKQIYKHHEYKYIYIHDDKINFKDNLIVYPSNLLLLPLRETFFVFFFFFSHANSISFPLRVKWDSFCKEIFMKGTSKNHNIKITYDKKYQDKNNYMKNEIIKEKDTKENEENDKERKDNYIGICSDIFYVNFENLNELNIGYELSETETGNFEYNYYKKKYILINNCNPKLNYYYKNFDSFIKVNKLENKLKNKLSKYYLIKGEKNNKDRTKAVVTEVETVEGEHNVLNTNKENALDAIHACIITEDDILNKIGGKKTKRHGFRLLVFHNNNITKDENFIKLKFSINFKYFNYCKIIKLRSHFFVHTFDFILINEKDLLLSLFDYMKNAICVSKGESLGDVNNNSEIDGFNGCQEIEQMKGNKESSKGRKIDSSMDGLNICKEDKTNDKESNIKNGEREQIDVFVNKLIDDLSLIKIKEHDKSKAKIKRYMEEINNFFNLNIDENMFDKFENYIDEIRHDFDSNIESCIETNESLRNEEEEKNIDKNEGCYEIFNDPDRNSSKLIMGKIDKFIWVHKLLNCLNNKLDYDLVDFVKKKNNELFYNYDQEDDISRNEEKDIVIKNTKERNKNKPGTHLLKNYCYNLNNENDVIYIIINNKNKVDLNLNVNCSGSINDNLKNIFNRCINNLIMKKEWQGLADFLKESNLEKNKYKKECNVENIIYGNYNRLKHLNNKYKMKNEEHYYNFLNNILNEKSEYCLMLKNNLFLDFVLFKDTVCSMKSAFIKIYLYSDNINMYRDKIFINLSKSEQICNMSIKSEIKSLHLLNPYKVAKNGDKCIFINSIYIDKGILKNYKVLEKNERNENICKCFEEILKPYEVILLNSSNFRKNIICTFSDISDVLLNISDNKNIYISEHDDLKNDENKKIDTFLKGTPKSNEQCSNSLNELFFRNKNDIEIAKNSLCSTSDGKTANSENDIKIDCSNICIDKKAKKYIKICLENILHKEGNHVYKFDCNYKYIDDIDTKSKINTESSLKALSEHLIKSLYLTFYLYVNIEKPKMELLWGNKISHDKTIKFDFKYFNKKAYKKINKMYTDQLINDILYEDINEINGYFDETFSQKKCLNIYFINMKDINFYSYIYTKLFFEIKKIYIDSEEFDHTNTRIYHIKRKSKICIKLEIDEVKFKKEIKNKINSKKGKKHVYEDYLIFQYLTSEEHEKFIIECNYIVPFLIMKENKYIFHEFNNLRKENQIIENCKELNDVINNISDKVKENRITYNDIEIKDNTYYIYIKFSELKLYKFCLFLFNTTQIPITWTIKEEEDYIEQNYHLSKNSLNGIFHFSKTKNALFGKTYGACNTDYEKEEKRTNPFLFPNYIIVTFAPIMEKDITKKYFIDIGNGYKIYFYLKGIYVPKNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDS6</accession>
    <name>V7PDS6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Condensin complex subunit 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1471"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1473"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1527"/>
            <end position="1537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1537" mass="181975" checksum="0044547A2F6E5BFB" modified="2014-02-19" version="1">MNILLTYLIYKNDNYSNYACLICLNMLKWMHIERKKQMFRLFTLKGILKRFLLCAHYLNDKEIMKIKKMENDQSISEEDIGVLKNIFMLLYESIDYLDISNLVNINSKNCIFELIKFYIELLKYPLIHSVHILCINYLIKIVIKCYDIRFEYNINVELYDIGPHVNIFVKIVNLIFAKILSILKDIKNSENVYYIEEINNINNLIALLFTNILNSCIRIIIPQVLYNDKQKQKYLLNNEMTRTTKINKIKDDELDAEDKIVLNACNPVFSFIEIFIINNSDKYEKTVFTDLIKIIINNCRKIEKKYNVMKIIHDEFMLHIKGEDNKKNGDKYLDKNYLKTKKISKKRLESTASFKISDECNSSVYSETEGEDEEEEEDEEKGREDGKSEMGDNQTNGYESEKETNKYCPVSKIKNKTKSTLEIDNKKYCIVYESVMIRYLNLLLKYMNCEKHQIRNMILDLFLILLKKKKTNKNENIYEKLFRLFLERLEDPNIVVKSKALSILVTLTNKKHHNNNLVRNFIYNKRKEKINMYKIISSNIFSHRSNIRKLTIQYIEVIFETLISQKLNYKIFLIFISNYLYSLSFDSILSVRRQVLLTVNILFLMASNDEYIGKLWITIILSAITDTEETIKDEAISIFINTFMKASINCSMFNTNEKKINQVLEENGMTYFKALTTFSHELKTKKDDYKNTKSDVEVNPIVKNGSITDSVTSDTNQRKYSNNIIKNKEGLEKEREECDKNNDGVILLIEIWEKYFESNMDNYFLTLLKMMTKYDLLNFNLILLCLTQKKNNVLEEFIKGINIFIYNLRYFSIRTWNTFIFDFIIELSKEYQNSINFESILFLLSRCYKIYLMNEKKNINKSNIIDKNIMAEKKIENIKENPEINNTIKTEFLFDSILTDQELANEKKSCPNGILKNIMLKLFTIISNLLNNENNEVNENFLEIIENTIFNFNCPMCFIYIILNILIKKKKNVNQFIDKLKNKIHFFFEKIEIIPYNNVFCNILVTFIFLINHYKKQDTEFLTMASEKLKIVYENVCKDKSAGSNETAIGGEDSDNLNHLGENIIMVKNCIYMAQCVLIIDKDMMNKSDFFLTLEKDLKNSNTCMNILNNLIILTYYMIKNFGSSCNKFVFNLLRFFKHENSFIRYLSFYMLSKLISEDYVKFNNQFFFGFLYLLADKNEIIRKQSLSVFKHIVLIYNKSNLINYMIDFIFVLNNFYSIKLSKHLIHIGNHFEIKNPEDRYKIYCLLIENLTNSEKFSFQQKLINEYLIQYVYDYDNYYFSDEHAKEKKGDDGINTRAKHNNIIPINDEGNEGSVLKDVLLILSSRLMKIKIKKDFAKLEEKNKNIKIKNVESSVKVLNDLMKNILKKNTLPILLSLRAIMLKTKSFFFKYINNLIIYLCIDYKDSLEELILEAHTRNEIFSDIQHFVYTDVIHSVHNNNDIFNKNSNINIDINFLELSQNQMIEHNLEKNMHNKNIRKKGNIHKKKNDDNSDDTSDNSDRSSDYEEVSNVLHSIHNRHQLSNNIKINKKTKKNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDU2</accession>
    <name>V7PDU2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_04984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDU2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB57165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="286" mass="33884" checksum="21DABA5B9E40EF08" modified="2014-02-19" version="1">MCDKDGELYALKKYEKMFLEKKREFQKKTKDNKIVIKTKYDDLKNELKIITDIKNEYCLSCKEIITNNDEIYIVNKYMENESILKYDQCFFIFHPNESYFIPIPVIKCIVTNILKSLLYVHTKKNICHRDVKPSNILLDKNGIIKLNDFGDSEYMINKKIKGTRGTYKFMPPEFFVNTKCYYGEKVDIWSLGICIYALFYRVLPFSNKSGLINLFQEIANEEIKYHIDRNYFLSKVRKDATKKISHDSLSNEDINFLKIFLKKKPTERCTIKEALVSLSTKIQNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDU9</accession>
    <name>V7PDU9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sec16 Sec23-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_04992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDU9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="10">
        <location>
            <begin position="704"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1127"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1134"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB57175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1266" mass="142821" checksum="1042742C9A376BB5" modified="2014-02-19" version="1">MALKSINISGNFDWCPFEEYKNYLICFNSHNLLYSNNGSLNNYTYLLDINLNNDIRSLDIVHKLNFEEALNRENNKSSKTSSNEYVTSFEWINCNNFVESQNENELNKGIIVGGLTNGNVILLNAQNLFDTSNGINYENFILSQTNIHESSINCLECNKHKNNLIATGGNDGQLFIIDIENIFCPTSYDPYLDKNNLQKITCLNWNKKVSHILATSSNNGNTIIWDLKIKKSAVSFRDPHSRTKTSSLCWLENQPTQILISYDDDKNPCLQLWDLRNSNYPIKEIIGHSKGINNICFSNIDSNLLLSSGKDVTKCWYLNSNNFDIYNEVNNSGNNIYSKWSPFIPDIFASYTSMDTIQINSINNGNKMTNKYIPTFYKKDTSICFGFGGKICLFDNIKSDNSSNLSASENVSNKNVNQMNQNNVDEGNIQINKNKGLQNESGNNNNPYLIKCHIYPTEVDLIEEADKFEKYIACGKYQEFCENKIAKCDDYHEKLTWKILQLLCTSQKEEIVKHIGYDMNEIHQKIVENVGEESGFIFKKYKCETNENMNISGNITSNNLEINSDVNNKHDNTRMSNLNNGENISGYSNYGNNMHGEFVTSQMQENEQSFNESYDLDPEKFFRELGEKNEIEKNQENEISKEDKNGKEKLKDSLNNVDSNTKDIINTIKCQNFENVLGEINEDSKPNSNKTNSNNWNNGIESIIKECLLVGNIEAAVELCLYQNRMADALLLSSFGGENLWHKTKNIYIKKQNDSFLRNINYVLDDNLECLVKTIDLSSWDEALSILCTYAINNPNFNNLCEILAKRLQNEKFDVRSASICYLCASNFPETVEIWDSMPSSKSTLLNALQDIVEKITVLKMVIKYNKYNSTMNQKINQYAELLANSGRLKAAMTFLSFIEDDKSIGNLTLRDRIFNSAAHIMPSHIKPPPSPFQYFDIKPFGLSQKYNNNNNNVNASIQGIYNKSQIHPNKSLTSIVPPLPMSEMHKQHGPSTPMAPFSHNSPTKFNTQMIGGSSGVSRLPPQKDFMGSTDSTSNRGYSTSNFNNNVKYPSTGMGSLYIPPPNIPSHSTTPINASPSPYNSVQNLAHLPSHPNLKLEHENKLGQVSNMFESQSYTNVNKAMQNSMGPPPLAVTPPSNQIQGVSRSSFSVSQNNIPPPFPQRNRHASVSTPMGNPIQPNVPFNQEPQLNKREPIDSQIYNPVSPPPQQTQVPTQMQNTFTPQQSYSQNKIGFAPPSGIKTTSPVAGAMSITPGMPVPWPIPTTTQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDV2</accession>
    <name>V7PDV2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDV2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="110" mass="12994" checksum="F441A3E4A378B23D" modified="2014-02-19" version="1">MEQIFNPLWLSSFEEDIDSYIFISSRDNKLYLGILRTYDQHGNIFLTHCVEKIIIPEQNYFSDVYVGKKNKIIKFGENKIVKIGPKTEMGIYIKNKKLNGYKYMSLYTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDV6</accession>
    <name>V7PDV6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_05301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDV6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB56947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="147" mass="17839" checksum="0F8FA44E3E12773B" modified="2014-02-19" version="1">MAHFSNFIQKCQFEGCRYHDFLPHKCEYCELMFCELHKKAQDHVCSKLKHSDLKKVILCEYCNAVIPDEEEEIKWHLIHKCTYIKKATKPKICDKEKCKTVLNDINSYFCKQCKKTFCLPHRYDFAHKCISDNKYKKGFFEKYFYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDV7</accession>
    <name>V7PDV7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDV7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UAS" evidence="1">
        <location>
            <begin position="113"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="339" mass="39869" checksum="CB02E82A7F907D1B" modified="2014-02-19" version="1">MCNGDSDSAVKLYCEINGDRSLRNENNQIINEINYENQTTIEETLDDVIRNESKEKEKIKKSNNDDSNDIEYVREPDKHFSQALINDMDNLNFVHFNDKNKNIKKTKIELGDTIGKLFSLPEFLICPLSLEDVRKRSKIENKYIIVNIQNSEFESLKLNRDIWNNETIQEIIKDSFIFWQRDEHDQDAIIFMNTYKITSLPCICVLCKRTGRKLKVWNTKTFNDPICAQSQLYELIETVEIKPNNNYSTINVNNKNVELKNELVKTDYEQVNHYLSNNINKAYTNEKDVTNCVNSQPNNSQKNTDNVKIDMTDQLKEYGTINNELLELHKFRMQRAQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDW9</accession>
    <name>V7PDW9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_05405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDW9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB56558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="65297" checksum="62B0103A6676B68D" modified="2014-02-19" version="1">MSAVTNSSGPMKIKRSVCVKYLKFLYYLKNSNLEKQWNRYYCCVFKRVLDENITIKQLAERKYLNKIKLIKNKEIRYNKLLSYLVSKPVKISSFDFNDTLVNTKHGKHSNNILYDRTIFKALFNLLNIRNYQIVIFSNQTNVSSCVHDYENLKFNKLPNFFSKISDFKKTLFYFNSLFISENSQKYKQTKTPTNIQNNPLSFSSASSLILWDNIKSQEKYRNSFLQNETNIFMKQLKHSDCYIYLIRKYFDRFYTSSHVNNYKKKQKKIYIFPKNNKYRLAERFVNNSNLREKKKKMKSHNNYKGCKRSKIVLNCNSLNYFFSLGKCEISEIDIYSKPEIGQYCLYMCIEGIKYLIILKYYFNDFYKFIENNINMITNEDLKKFIKLSIDIFNLEEICILTKKIKKRNYLNINKLALKILDTYINKIIHKNEKYILLKEKYKNDIQFIEFFLCDQIYNSSINFNEKKLFNKLNNDDFLKNLLFWLVYKNKIIIKLTNHFSTLLFNFRHSFYVGNNVGRSFDMSDIDLKVRIKYIISTYFVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDX6</accession>
    <name>V7PDX6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">YYC_04572</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000147">
        <property type="term" value="P:positive regulation of cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000766">
        <property type="entry name" value="CAMK/CDPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="929"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1041"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="1336"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="245"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETB57756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1433" mass="171944" checksum="DC806DFB966F7D5F" modified="2014-02-19" version="1">MVLELLKSNYERNDEHYYNEKVENNTSKHKKKKKKKHILVEESEKDDRNLDSENNEEAYNTYELIKVRPNTIYEEKYDFSFQNLYKKGFREKNNMRESYRNSKDIIQYGTNENDIFTEDMFENDNFDDDSFVEDDTMDYKTYNSYTKPEFNLFSKYSTESIKKNIMNNKKDSKIEDFYKKYKNNSEYSKQANEHDANIIQFLNNNKKSVDYGKMKDINFKKNDSHNYSESNKYKNEFLKNYNYDNNYTNNYERDNNQDSNSYYYADENETKDNNEEDDDTGDTYDDNEEDEDNRDDNDDYSQYNQCEVESDTNQIRSNEKRYNESIKHINESNLKINKESLLKRETYNKRDNIFYIKKDIIPYKKEHNNNIFSLYDSSKNNNEHNNNYETKFVNYKHDGEKKDEQWLTNVKKERNEEFLKKYMYENALKKTYSSKDLQFNRLGDEKNILHHDINVDNKMFRLDKLERSNTQDIRNKTNKYNMFRHDTTELSKLRYKDEINDYSEYANKCLEGNIYDEDDSYILKRKELGHKELKVIDNPILNINHDDKKKTNIKSFLDKIKYRKNNELFLKNEHEKYADIQETNKKDKIKMKFADILHTKNFSNFFHRGKSSIAKSLSPNNNKKNANFNNEAFNLNILEKKDKNSDYKQYNIKCFPYDHENTSFHPSVREETKYYENKESRKRLDYNCDEDNYIENSIRRYNENNIDYNSINIEKTINLREDIKYNEFLNKPDKINSEKFSNNFSDNKQKSLKNDDSNKIRDTNKLYYHNNSDNALRSNYIKKESTEKIYDILESNSNNMRKFINKMDYYTKKYEQNLYKKDEDIYTKENNFPDSRQAFYNKSNSPMKVKDETKDSQYEDYNRIKYKLKMKQEKQDEEDETDINIDKKLSRKMIENNKLKEQNESNDELIVTPFYIKSKIDKVLKNSEIFERSARATFKQFDVKNKNFLHFSEIESLIQKLCYNLELPPVDKKILSIVYKDYDSSKNNCMNYMDFRQMYWDLLKQIKKKYYPTKNFKIKRNCIISRKKLQGYDYSSIYNYLSFKKILGCGAFGEVHLVEDNICKLYKVVKILKKKKMKNIKVNEEINVLIYLDHPNIIKIFDVYESVNCTYIVMELCEGGELMSKIKKPEIFSEIYIKNIMFQILCAIAYMHSNNIAHKDLKPENILFKTDGYDTLKIIDFGLAELINKSEGISKTAAGTVLYMAPEVFKKKFTIKCDIWSAGVIMYFLFTKSLPFTGNTYEEVKKNIFNNEPDYQSLKLKMSKPALHLLKLMLEKDYSKRPMAAVLLHHPWFQGYFDPIDILPSTLSNIKSYMKNSNIRNVIVNIMAHELCVINNHVKYINDIFLKTDTNHNGSLSHREIYNVLSNAGVKKWDINRMIQALDINDKGCITYTEFIAGCYRWKNIESTFLKAAFNKIDKVIRETNMCIYTYMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PE43</accession>
    <name>V7PE43_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PE43"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="366" mass="43069" checksum="F5069293B3948B2C" modified="2014-02-19" version="1">MQDEGENKKEKDFERIDDTQNDSIEEMERILEENAKAKIEKKKKHKKKTEKKSSKNRLDTKDIFESDNEINKSPFFSDISSYADYCTSDDGNKKKNKNDKITLPVNKKETKSNDENFNMINGKTKRDYPNYKNGVKENQNEYNYSEKEDNHSDNSEQNTTSAPDTVPNDWFFSKIKEIIEPNINQETLNQLITNNYNSFSEANTGIYDLIDKIIHTNNNTYDNSQNSMSIINKQSYHGNIYDHYNSMDVSPNDNYNFINYSIYCINKELSANVETEAINMMKIYAHTFNKYKKDINYKDDLYKDLLNEAEEQSTIILKNNRKKRIYKIDFFNLANMNSENYNNIVESQNVQTPKIKLEDIFKISVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PE57</accession>
    <name>V7PE57_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PE57"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="252" mass="30222" checksum="05A08B208E5250F5" modified="2014-02-19" version="1">MLLLYLVFVVIPFIVFSYYIYKSVLALIHEKQKKNEFFNCLKSDNKQYTAFEIFANKYEVEKYAIYLKAIRNIQVDYKTNILDDINKEGNEEDKENDQKIDSILEDIYNDTQYAEHNVIGNPQSSWMRKLSNADIIKLKVMLLKKTILFLPICNKIFHDKNKKSRLYNNYFIDDNMSRDLDIQCDQFLEEFNLIIYEANCITDKWGNQFIKQLIHIPFSQYAISSHDLIFQHFQEKQLFLTRTEFFTTTKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PE59</accession>
    <name>V7PE59_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_05450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PE59"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="385"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB56613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="456" mass="51952" checksum="3682EC879FBA39C9" modified="2014-02-19" version="1">MSSKMETPKDLSEMTDSDFSNIEDKTDDKNEPSEQNEKNEDEKKNKKKISLKKPKKKSSISSKTSQKNNKKVIQNKTKKKTNGLLACPPPPTHPPPPPPPPFIPKEKQQNWKLKKKTNNSDINNDIISITTYPANSNNNNNNNPHYRINEPHMYNKSLSIPSIPGPTPPYPSNIYNHPVSNINSPPCTNTNIKVNLQTNHNYNNNFKKNYKINNIPESESYVMTSPTLISSSAQQTNTPMNIHVDRKHTLISNNSITQNKDYPYIDIQHNNNNMLSFPSSPKQPYSNISIPPNPNYYSPNNLRPTDYIEDKIYYPNYQNNIDHNNTPKYYQPVVNAWNGAAPPPIPNNPYQGNPKFSPHDYNPEKMNYKDKPIRMDNAPYDPKPHNIIITNIPKNLTSRDIMETFKCMGNVLGAGIMMTSKGEHSGCAYVTFPNIEIAALAASIKFKQLNLFFHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PE61</accession>
    <name>V7PE61_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PE61"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="345" mass="41072" checksum="17C8DD5D68B1B037" modified="2014-02-19" version="1">MVINQGITKCQNNEKLPNNNQKSNNQMQLCKINYYDNIIDLTKLENTNGKNTILEKKKKDYIKSDNENAVKIKNLSISKKNQTPPLIKKTNKINNNSKNICDDTSHTSNVSYIMKRTINRIKNVSNNHQNILKNNVFKTKFFNKIYNAEEVYKMNLDYDSTLSNIQKKENEKIKMLYFKYYKCLFCVDEKDIEHFCFKKYDNDLSNNYCKPCKKFFKLIISHGMKYKGKLINLNFIHPEIQNITFTYKCNKHHMFHISLFHIVHNLWCPNDYCLFECRNKNVKNYSTEFFRLKELDTMEKQKNIFLRAKIYCLFNSYGAIPDTNKNEQSSYSSDGKYIPQIEFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PE83</accession>
    <name>V7PE83_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PE83"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="190" mass="22473" checksum="08613C2E48D82243" modified="2014-02-19" version="1">MCNNIGIIFFEKMYRNKIMQICIIYILYIILFSSIIRTKFAKKIAKKIIKKNIKKNITNTNAYSIRNENKSLVQLYKQKKEKKKLFIKNYQLRNKKRINYLKTIFNSISGSQFPQNSDIDSYNLTPKLKKTVQFFQSLSDNPYNKSQHVILMGKKCQPMPNELKTRQNQVLVKNGTNYISIISSSFFLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PE95</accession>
    <name>V7PE95_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LSM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_05476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PE95"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB56653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10073" checksum="27DEA447EF8EEC03" modified="2014-02-19" version="1">MSSTIIENKENLLKGIGKKETLRAFLEMIMNESKYSSFKVVVKDNREFLGSIKYLDKHNLFLINCEEHYKGSPTHGTPMCIYISIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFW1</accession>
    <name>V7PFW1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_03950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFW1"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB58324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="404" mass="48283" checksum="5C32AE808E651E1F" modified="2014-02-19" version="1">MGNSITEKRSKIFKQNKSYFSDINNIDYTKKIIYFLGILVRIITYYYGLWQDKNLNVKFTDIDYYVFSDAAKYVLNNKSPYNRYTYRYTPLLAYLMIPNFIINFSFGKFLFSSIDFLVSIIIIKIIKIKYPENKNYILYASLWLLNPLVITISIRGNADCIPCLLVLLTVFFIYQKKIYVSAFFYGLSVNFKIYPIIYSLPLMLYLNKNYLNKDNIFQLKQIKTEGIYINKIIRIFYIIRNFFKELFKLNTDQLKFSLFSFTTFLALNLIFYAIYGYEFLYESFIYHLVRQDHKHNFSLFFYIMYLTIENNSKIIPLITFIPQFVLVALFGFKYAKSNLELSMFLQTLSFIALNKVITSQYFIWCTPFLPIILNSITLNRVTKTKSEQVYIQIYKFITPKINEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFW2</accession>
    <name>V7PFW2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFW2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="146" mass="18166" checksum="DD218A160C5E6D61" modified="2014-02-19" version="1">MDLIKLMDYRNISHDYKALLREKKKNSEKERLAALVIQKCFRGFLVRKTNIIYRHLLNNIRNNIEILRCKYLLKKLKREKLDDQRNMYLSDNATKIQKIFRGFYSRKYIHNYYKWKENIIEIDRYVKDQKNKMLYEIEEKRIKQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFW5</accession>
    <name>V7PFW5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_03950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFW5"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB58329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="366" mass="43652" checksum="A3BF5B79DE5D1B4B" modified="2014-02-19" version="1">MGNSITEKRSKIFKQNKSYFSDINNIDYTKKIIYFLGILVRIITYYYGLWQDKNLNVKFTDIDYYVFSDAAKYVLNNKSPYNRYTYRYTPLLAYLMIPNFIINFSFGKFLFSSIDFLVSIIIIKIIKIKYPENKNYILYASLWLLNPLVITISIRGNADCIPCLLVLLTVFFIYQKKIYVSAFFYGLSVNFKIYPIIYSLPLMLYLNKNYLNKDNIFQLKQIKTEGIYINKIIRIFYIIRNFFKELFKLNTDQLKFSLFSFTTFLALNLIFYAIYGYEFLYESFIYHLVRQDHKHNFSLFFYIMYLTIENNSKIIPLITFIPQFVLVALFGFKYAKSNLELSMFLQTLSFIALNKVITSQVNITQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFW7</accession>
    <name>V7PFW7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_04688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFW7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="1279" mass="148027" checksum="F36E9A9D27BD0535" modified="2014-02-19" version="1">MSTMVESKMGMQGENDNQCNSNNDLNKESTKNDVNINENNTNINPDNDNNNNANKANTNNDNNDDEKKEKEENKSSNRWADMCEDFDSPLDMNNYSNIYEIYVRNLHIDITKEEIYTMFEGYRIKRINILNKKGKTAAAYIEFDNAEDMNRSLELNGKMLYSGNNTFEHGTISVIINKDKTKAFNLNQKQNKFKKTTNRNNNFGNVRQGNNIMNNYNNNNNNANNNGNNNMNGNNMFSLNNNSFFNDNNNNNNMRMGMKGGNDNLNSSFSYNNMKSNYMNNQQGINNMNQSNNNMHSQNDNKNSNSNFAFKNMNYQNKNANANANANANANANANANANANADNTTATPEQRKKLVLKKRTVPLDQNSYIANPNIFGEAKPVDTNPDKIISESISKEKDNNSGDENNNSNELKFENQEEEESGMKMNNENRKGMIRSNSNKNVFNYKKNNNLNKNSNYNNLNKNNGNSNNGKNSSASKKNIFMSNKNNSGNNTNINMKNNMNNLDNSTNLSGNINSIGSDTNMKRMNMNKGFKNLDINNNAHENKGYNSNVDAEANLKSSYNKSLNYMNSYNDSNGNSNGNSNGNNSKNAFSTLRNNLKSDKKNEDGLHLTKSKDLNIIKKDDKANIKNIIMKNIKREDGNNKNSSNIRNHSIISSAYKNSSSNNEDGQNNMKFSKNYNKFGSDNETINKDNHNLRKGNENNSKKNEDGFENMNRNIIKGSGDGNNYNKNSNSYNYNIENLYDNSLKYVKNSNNSNKAKKLTSVKTVKVITTEKKNEEEHNKVFDSKDKNKDDINNDIGNGNSNYGNNNESNSNNKYYEHDNKKIDNNYDDSYRSNNDNYTYESESSENAKDITSKNLKSTLLQNKTKKKTKKKINNNDKEENSNSNNNNNNNSNVGDENNTQKNAKTQKIDILIKPNLKKGENIWEARTNLLGEHNENNNIIDNDKHSCSHSRRSRSHSNKLSRASSKRRDSSVRRRDRYSRKYDRRENRRDEKKSDRKDERRHSRRDRSRRGESRRGESRRGESRRSERKDDKKDDRDDRDGRDERDDESRMGESRRGESRRGESRRGDRDEHRRNYEKRSSRSNNYEKRRSSKYESVDKKTYDSKEYNSSDDKKKHRDSNDKISYKETYDRLSYNENYEKNGKDNNYRDSYHRNNNYIDYEKMDNKYFSNNYNSIRHKNYNNGNKHHNFHSKINNYSYSNNYKSSNYYNNKYPSKNSSYYKSTKGQLKINEKEKSESKSEIQVIPKKAIVSTVKTNNVSIKKNRYECLDDGDESDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFX4</accession>
    <name>V7PFX4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_05042</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the activator 1 large subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
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        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
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        <property type="entry name" value="BRCT domain"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="151"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
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    </feature>
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            <begin position="100"/>
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        <location>
            <begin position="809"/>
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        <location>
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        <location>
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        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB57243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="869" mass="99608" checksum="9EBA4CDD337DE1B8" modified="2014-02-19" version="1">MSSKEKNLFSDNSSDEGRKKKRLKKISSNLFDDEDQNMLNNSDAKSVVEIKDESDEELTKVSKNSGKEQTGNISNTNNQSKKIPLENVDEYFSIIETGSKKVTSNSKRERSHDSDLLEQNRSKKKHISTEDNNILQKNETNVSQNFDYLPFINKKFVLTGVFKTYSRDDLQNKIKEHGGSVMSAVSSRTHYLVHGEYLEDGRLYSEGKKYQKAYELSKQSKSIIKILNEEELLQMFPNQQSNTEQEKNGQEKNGQEKNGQEKNGQEKNGQEKNGPYQSVKHEQEQNMPYQSVKTGQEQSVKNGQEQSVKKAPQVLNQLWVDKYKPTKLEDLVGNTQNVFKLKTWLSSWDDVCIKGLKKQVTKTFRGNFENINAKCALLSGPAGIGKTTTAKIVSMDSGYNVIEFNASDERNKAAVEKISEMATGGYSITSLNNKSLKKTCIIMDEVDGMSSGDKGGSSAILKLIEKTKCPIICICNDRQNSKMRTLANKCYDLKFTTPNKNSVVKRLLEICKNENLMMEPNALELLWESSNGDIRQILNALQLLSKTYKRIQFLDIKKDINNSNKNVQSLANPFEITLKLLNFHESSKLKIREIMDLFFVDYELIPYFISENYTNIFNDNDKSNNPMNKWNTFAQISYDLSLAEKIKYNLKTTMDYSLLPHFSILSCVCPVMRIRSLKSFMQGRINFPSAFGKISTFNKNKRLLNELCFNLSYKLNVYPKYMITSGFLNYIYYKIIVLLQKNNINDSIQLMEQYNITKEMLIENIPSLRLPTQENLYDKLDSKTKASFTRQYNAIHVVKNDPNAVKKSLKSIDKKSSYKNNEDEIDEDMDDFSDSKEDKDDDVLVKAKLDKKNTTKNKLATKPKASKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFY9</accession>
    <name>V7PFY9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFY9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="831" mass="97000" checksum="E942FEFED1BE6223" modified="2014-02-19" version="1">MKNRLIKDNVENSEVCNTKKKTKDQIVIDYVYKNIFNKNIFLNIFKRNNYNGIEKNKTITKKDTSNIDIEKRKEEIENYKKEKNDNEEYLLFLSYVYNDLISFIENDKEYHLKNSEFLDIEDLIIDICGNICHKSFNNIKKIFTKSLTDQDNVYNDMNDKCIDDEINENKNFNEPSFFFIPPMEFIVSHIYKLNSNLNNNHLCKEREDMQTFIKNNNYDKKCNILNDILNNEPPLKTKEDEIQNEFENETNKKKKNSMYIYLNRINDKFVSNSSQDEKSKFSLEKEIKINDHKINDSIFYYPYKEINESSDYTHDSDGYNSSSQDELTSESINSLETLNEQISNKESRHDTSQNGINISHEQSENEILNVSNFKENKIISNISMNERSLYKENNESETNSKHVDNLNNYHSLKGYDSNSIFSKSFNVANAGNADNVANTDNGDVANVANTDNGDVANVANTDNGDDNNGDDDNGDDDDDNGDDDDDNGDDDDDNDHSIHKRNEPELPEDFIISYRYQESEHKDIDTYKCSNKEENKNGCQEKRDPVYTNRDDDDDNDDDDNDGDDNDGDDNGDDDNGDDDNGDDDNGDDDNGDDDNGDDDNDNDNNDNDNNDNENDNNSITNEEIKRVANIPNSINPTETQNVLGTYENNNIMTNIELAKINSNKMIKYTNYDDPQINNVCIDYEERDNTIKDNIIINSDDKIKMCEYDKHSFENKQLIIKHNEYYEKLNKMLINKKEKIYKEQKEYTKNNNLHDDYYYFKYVNTYEDNLNPYCYTKILKKANIQITRSPFPQFLRDIQIYNIPTKKIRLKKTNITLKTENVGVVISLKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFZ1</accession>
    <name>V7PFZ1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1753" mass="209226" checksum="EE9CB4C66D779980" modified="2014-02-19" version="1">MDRQKNIKRDKEKINFQKNDEIIDQSDKPKFINIKDKRQTIQILNMYNYNYKNKEEYGDIKKYSVLNNCKNKSEENELIKNTMMGDKKICEVLDGKFDNEMNKNKINNPKENDNDKNMSGNMSGNILKNSVKNVHVSSCNKIKPNVNFPKEIPYSPNDPHSKKCYDTYLMNKKKCVTNFLKKNSFHTTSSENILHNFKTESHDLLVSKEYQMKEKKDKTNNIIDEKMIKLFDRSKREDNEKVDIFDHTQKENLYEEIEKINNKKQNNIVSRIKKITPHHYYNYVSKLCKYNSIHGKNKLKRKPTKLKLAYSKVIRMRLAKTELAKAMLTKKKNEKKKLAKMYVNNNNVFIKYLKIYKNENRYNKNIISNINNLDIISKRDILSLPDKPVYLYELDNYRFKLNKNIDTPALKVENEDIDFFFKYKNTWLELFFYNNYTSKEILYNYIIIRLNFELMIQEIKDIVIMDMNTNHFSYPYIYNAYLISPISVHDIDNSLRIQKVTSDYSFINNGSWAFLRKKKKNIKKKSHIENNINEKNVPNLLHMTRNKYYINHNFWSRLRSNINSSRNYDIQNNNNFDSLSTMHSFNMNCSDNIQNFIKEEEKTKIDTKEFFQYSENRATFLSNFHSDTSKEKNTVSDANKKSVSNYNTFFLKNNNTTKLFNDNNLIDPSNIYITFTNSKIEPFFPYMCDNIFFLFYYYNNYLNMFIKTALENDKKKKMLMAHQHIQNVRERNRQHNESKKENEKEKEKEKEKNPQKSNKTELNIITEKTNDQENKSHLKSSIVLNKYNELPTKNILTVKRKITTIPIQITNYPFMNNLKIKNSINDKMYNSIFSKIVKKNSEKIKKELSKDNVDIPIYLWVIFGGKDMKSMDSLNMVYKMLRYATEIPPGEYEKYIRKLKKKKIQINCNTNTDYNHLYFGHNNNNYYNEKNKKKVNLREYNLNSNKIPNSNKIISESNNFLFFEKFNCCSCNDRQTKFYADHAMGTIRKNNKKNFDQNRQKNNENCVCGLSSNTMIRKKKKKKRTLPELNKELFPDNYLYNTSSEIYKRIVNYYNNYNKKYNKYGPNNYKEFLEFYHKENNENSCIKVEENKTYFKTDVPTKGITINKYNKENERNLKKNIKNETLYSNLSENIYSKKIRTNEDKLPKYFISNMCDEMPNEDKYYCANLWDQQKGEKRNTLNKYSNNMNTVSNNNNNNNNNNIMGSENKEQVVDEGKDKMEHNSKNPDSKTYDLFLEANDSDSSGQESDNNLYNFISYHMQGRNPSFEIKDEKIKSNKLNYTDIYGPVIYRSISRDCQDEKKQKSYNNDNHRNQKNKWNCNNKKEKRKVRYSFLLLDYPSYYNSTGHPSPLTFKTSAFCALKEAIKEIRKENQNANISINTLGYSLGCCVSLQLILDIAKSLYNDFYQDIYKIPYNKKEKEPIKEIKEDNKLSIKLNNNKNKINEYIYDSKKILTFENVLFFPKEEKYYSSNDIFQQDNEEKIKNTKVETEKKTDHNKLHLLESFLTEKNEPTHINDNESTTFEISNCCNTKPKVKTCFYKNNIYNPNEPDKMNTLKLEENKTNVEKVDKYGKVYLNVTKKNDLKNNHVQNYEIRKNSSLKINVKEMNMHEEIVKEKKEIDNLKITVDKVILIAPFTNTQKLVKDYIHGEKDTLVPYNMSLTLYKLTNDLIIKYSMFNIKTFLYIFKEDCHSSILNSQTENNILQIIFNPFRLHPFSTTFIHKFHFDLYKDLYLLKTVYLQYISRVTSNLRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFZ9</accession>
    <name>V7PFZ9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_04081</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFZ9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764314" description="J domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="64"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="270"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB58486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="390" mass="46712" checksum="547029A7225F7F0E" modified="2014-02-19" version="1">MWPIAILLFGGGVLLAKKGMNYMKNQKVGLNKNFFFPSNLNKNLSNVFLKPDMKGFERTMSKSEAYKILNINPTTNRERIREVHKQLMLKNHPDNGEMKKLYSKNLSVEELDELIKNEEIKYEYLKKENEKIKEKNLKIQKKLLNYVECDNFTCENNKNYNLEKYNIILESIIDYINKLKAIDTYMKNDIYYLFDNFFYCIKEAILKQNSLCQLMKNDMSYFNVPEKSELFRKNLLTLRKINEHNSILRARIFLFNKFKEKNENLIHANFEQLELKYKNLKGKENILESKIQNLNNKIKKSTEKKLHYDEKKNYLKNLLEDKILMLEESYNEIKKKKQLINNLKVKKEESVKKFNLAETGNVTKGVIEEYHDKREHLKKLNEMVRQISYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PG84</accession>
    <name>V7PG84_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleosome assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_04857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635806">
        <property type="protein sequence ID" value="ETB57353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PG84"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000004">
        <property type="entry name" value="Nucleosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB57353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="36823" checksum="73D0F5EF4E076A7E" modified="2014-02-19" version="1">MTDLTEEQKETLKKLKLYQKEYYDYESKFEYELFLLRQKYHDLYGPIYDKRREALVGSGEAKIGTPNLPEFWLRALRNNNTVSHVIEDHDEEILVYLNDIRCDYIKKNKEKKEGFILSFHFVKNPFFSNSVLTKTYHMKCVDCDNEPVLLHTEATVIDWYENKNILKKNVVKKQHNKNSREVKTVQQTVNRDSFFHFFTSHKVPNSNVIKQLSKHEVAQLEMIIEGDYEVALTIKERIIPYAVDYYLGIIIESESNSIVSDVDSSYTSSENNSNYNSYESNNSAYNDENSNVDTNEYDDNDDEGAKSNEEPLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PG88</accession>
    <name>V7PG88_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Magnesium-dependent phosphatase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PG88"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20500" checksum="7B23BE3099E86A13" modified="2014-02-19" version="1">MAVFDFDLTLIGKHSGGYIDKLNDIEDIGTSVTNAFKILSKRLYENNIKITVATFSDDEAIRYSKVKSPSLIAGEELIQHCIKHSNCETKIERVYAYYPYYYKEPKKYMALGLKEPMSNDKSYHLKRIRNEFSVNINEIIFFDDDVKNCISAKKEGYITFNVTGKKGFNFKDIKLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKA2</accession>
    <name>V7PKA2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKA2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="568"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB59415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="891" mass="106596" checksum="E595E9E74233F16F" modified="2014-02-19" version="1">MDQHQNYSNEKNINNEKIRKDPNFSEKLLKNLRDNIFENNNCINMNSSENSSFLQTNLEKNTNFYINESEKFRDNQINKNCTNSIKREHNVDGENVPISSCNIDINDNSSDNNFKVLEKLHNGDIEHTNFVNDQLDNSKQNVCGNIKRCENGNAENVEKIEKSGSTENVEKNGSMENVEKNGSMENKCTFKMEEYISNKSVEGNTFKENKDQICEDSKRCEENENPNLETKRKNEHSFSKEIKALNPPKNVYEYNHNVIYHELYIELLEVNKNLQNEIKNLEKIIEMQKELIKSKEGDIFENNNMIEKRKMSSKSFVNNNYFLNFFNKKNKTSKKKDDEQGKADNEEDNEIFEKDEGLAESNYNYNQQRKGSMTRFQNMPFSFFSDKSSKQKKQKSTESINTINLSIQEKDNEKQKNKRNIGTPKWTKQFDYKWIKSINNSNSFQECEFIYNDDMKKNDEIDNDENSDINNKYMKLALRENEYVEFYDNDDSCTFDNSNNKMNKKKSYTFFKDKSNSKEIEKYRDCDYKDINTIKEITLIKYWYNKIIPLINDEKKKYTLIELIMMNYMPQVIREYFWKENINNKLNITDYFVKVLIKNANFIQIYIYINNKQYYNIFSRYFKNLINLEKSSINIVPSLLTENCFVDENELINTVKESELYKKMITEKIFIEDDEEISIDIKENGKVTCSEKSIKMNTELNSISSNLNKDEKCDKENNKKDKIEMKNFEHLNINILQRYSIHKFFYQILIDLDRTMYIIKKNQEYYHRTNIDKDNFLFDLNIHDIKKNLNKLLQMYVIFKPELGYIQGMSYIALVFVLHCKLEKAFIHFANFMEYKNMRNLYSFNKQEIKIFLFTIKEILTKKNIDVYKEIVKHYNIDNIFIQWAYTMFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKA7</accession>
    <name>V7PKA7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_02908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053276">
        <property type="entry name" value="MtDNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48448">
        <property type="entry name" value="MUTL PROTEIN ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48448:SF1">
        <property type="entry name" value="MUTL PROTEIN ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="5">
        <location>
            <begin position="1344"/>
            <end position="1441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB59420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1444" mass="171079" checksum="A4192953C561B4D9" modified="2014-02-19" version="1">MKYRVVKSCICIFIIFLMSLKNTMSLKKKLMFIYSNKRRLISVNIKRKGIIYLNKKFINSLIYTKEDEIYKINDLKESYKLRDDDIFENKDKYISKEDTNNIISNSLCEKLSNLENTKCENDETNISCSSNLRNGFTPSDYELRLYKNKCMIPIYWIKKLEKLKNINAINCIEYLKGDNLLYFDHYKNKGLLKFLNDEKKKYNNCIILSRVGDFYETYGLDSIFLIEFLNIKKMNNKLSCGFIKSSINKALSILTNNNLNVCIYEEINEQSFKAKKRYLSQIVTPEMPIYLNNIQYCFENDKNKDELNEDNTNNSFPNYYDLDIKEIVCIYIQGKNILSLSKINLSLKTISIYDNITFDVLNVYLKNTNFLKAYIHQHNNTTFTKKITELFKIENYYLFNNFNNSFEFHMFILDKLKKNINIGGLFRVIKNKNIFNIIKESRSGEKDETELKQNFEYSFSSYCTPLNIFTSYNMGLYKQNNCYENRNNFLFYNIIDVKNKNSNSINIAESLEFFKNLFIFYPPFSVTKHIRYINEYIQKNVDTLIISNVRPFKNNIIITLLSNFKADYIILKKILSNVLAVHKCMNTYDYSFLSSLFHVLNHQNSFKLNIIKFYNLLENIKKILTTNLCLSNSQFSYHSKLFPFNDFVLYHESETNNIINENLLIDQNEDLEKHRNLLFQTILANYGGMDEKDEDYKIQVLNKLLKIDNPNGIIGVKRGRAGLERNKNNTKAGKDGKAGKDEAQHFFHPLNKKGDIMKNIFVTDDVLKKIKLYFASINRKKKKINEIIRNINMNLASSVHILSFVSNFLQIVQAFYNHTINSISRGWNLPICKHLDVNYEIKDFQTIEEKLNFIQKNMYNSYKENEKNHKVTQSEEKIEELNNGNFFSNNSKLKDDENNKILENLDKNNKILENLDKNTIEEITKIYNNKNYTNDTLTYIIGLKPYNINKDNVTKYNVLLKKKKFILLTGENMSGKTTLSFTIMCILFLSNLGMYAPCDKRSIVGKFREFYSLKNINYQEQIENMSLFREQTHYINSIIEEIKENYSINKKNTRDEEIFILFDEPCIATTPLDNAVIISAVAEYLKKYCGIIISHNYDLLNKIYQSENIEFKKINDNVNYLRDQPNGCVLTLEDGICKSSQALETCKYTNTDSNVLKLLKMYEKKYKLIYNLSNTLYYKFLKYLKNKKENKVDLNKFFDNFYESYNNGKYNMDIKNDEKTGNCKYVTDIFNFNEINEIINHENVNDNINDNTSGNDNLEFDENNHNSYMIKENNLDEKEFEKNKEKPIIYKDNNLININNDEFWEYEKYYESEIQVAIKTIENLIGKKIMYVRMDEDIPIFFKNKSIVYILCIFENFKKVEKKKPYFYIGISDNISERIKYHTKNLLKNKSLLRNEKKNNILNYKYNMTQFYTLLFNVENKNIAAKYEKQLTEFLKNSYDIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKB4</accession>
    <name>V7PKB4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_03250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKB4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB59879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="191" mass="21638" checksum="503FB8448DB6006F" modified="2014-02-19" version="1">MKPCAQVLVVPSLEDNFAYVIIDEKTKKAACFDPVEPDKILKKIENLNVDLEYAFCTHHHYDHSGGNIRIKELHKKIKVIGSAYETTPGATEKAYDSQIIRLGEICIKAIHAPCHTKGHMMYYAYKMDENKNEDLTCAPILFTGDTLFIAGCGRFFEGGAKEMFKNIEKAKTLRGETLIYCGHEYTLNNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKD8</accession>
    <name>V7PKD8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidyl peptidase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cathepsin C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cathepsin J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Dipeptidyl peptidase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dipeptidyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">YYC_03266</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKD8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.80">
        <property type="entry name" value="Cathepsin C, exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014882">
        <property type="entry name" value="CathepsinC_exc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036496">
        <property type="entry name" value="CathepsinC_exc_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08773">
        <property type="entry name" value="CathepsinC_exc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75001">
        <property type="entry name" value="Dipeptidyl peptidase I (cathepsin C), exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="14">
        <location>
            <begin position="351"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETB59904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="770" mass="90444" checksum="57A8A454909CC647" modified="2014-02-19" version="1">MFIYPFIYAKFFRYVLICSIYPLFLDALDPEIVKQRFEIKDKKIIAFNKDRTINIIENGKIVPEYSGYWRIVYDEGLHIEIYNSKNKNKEIYFSFFKFVKNGEVSYSYCNNLVMGVVSMYQLNDNTDIVKSNVNIVGNSRINNCNDNQSNSMVDDINVNSSNCVNKFEEKGKENNSSINNNITEKESGEKNGIFRYVYALYGVLKNSYLNILNNTVKVKENKSVALNDVDKLYGNNKDVKILIDHYNDNFIDFKTMPMKRYCWSGKKLDKNADKATNKISNMLSPLDVNADIQKHNYYINLIGDEKNKNILKNNKGKKRQTNNLQGVIDNPPTKKIKENSLFNMYSNRDITLKNFDWSDENDVKERLNGNIVRIFDEAIDQKECGSCYANSASRMINSRIRIKYSYIKKIDSLSFSNEQLLICDFFNQGCNGGYIYLSLKYAYENYLYTNKCFESYENLYINKDVKNNSLCDRFDTFKIFLKKKEKTNIYINNYPEKMEQKNEHVRMYNNFGNTHDNSNNRNDSNIHKKLIKGEDINYKYQSVDSGGQGKGNVSDDYLNEDYILVDKNMYEREKFKLDELDSCDTKIKVTKYEYLDIENEEDLKKYIYYNGPVAAAIEPSKSFIKYKKGILAGSFLKMQDGDKSNAYIWNKVDHAVVIVGWGEDTIENLIKKKIKINNSKKKTHSYDEYESKNDDNLDEDIYDEHINSYVKNTKEKDKVVKYWKILNSWGTNWGYNGYFYILRDENYFNIRSYLLICDVNLFVKNKNVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMD1</accession>
    <name>V7PMD1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_02974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="5">
        <location>
            <begin position="1604"/>
            <end position="2253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1912"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1991"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1920"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1999"/>
            <end position="2011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB59508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2659" mass="321179" checksum="D2828A822AC2BBA6" modified="2014-02-19" version="1">MYKVYNDNLREEERKKKKFEKAKEKLLKRQENSVYSFYSPINLDSIKKKKNSIILEEFNPFFNFFEQDPYKNIYHSNLNFPLKINMQFNRYFHKVITNLLMYHGIKKNIYVIVLNIINEISKHYHNYDYDILNNIKVKYFPYKNIKNSFYLQGLVFSNCSIYFDNLEIKNPKILLMNTERIAQYEALGVSYHDNYNYVNSFFKKFSSKNVNIILVHGELHFYIKKLLMSKKIYFFTSIKKKNIFRLSKMLRTKVLCYDNFNNFNNSYIAKGNYFKIQKYKKNIKNIYVCCNNNFITLCIFGKQNIRDSSNISDMYNFSDNKKIEIASQEEEKNKTKDTHIEKISNSNDGKNSLEYYFKNEIKRENILENFISIYYKKKSDDYIVDYNFLHKEKKIPFGGKEKNENKKKLLINHLKNVIIIKKVKKIIKYCIFLTFHIYKQMYLNHYMGRILVRPYLNNIKINKISDKNCINFYEKLNNSIISSLSSLFLFYNVQKIKITPINLMYYLFHLINIQSPLIRERMKILYKLIKPNDIIKEQIYNNYEHCFFHNAEKNKIIDIVNYFIFNSFMKNYESNYDYIYYYLNIINTTYLQYTYKDIIINDDDLLNNPCILNSSLHNDAGIEIESKVNEKVEKIIAKNMLFYCYNLEISKNIEMITYFICPNYMHINNTYNNINMYFFGTKYLTFENIFYNFFFNYKYICDISIQQFVEMIHSLSFTMICPLGSCSNYLIYHQICIQILLKGILITMKKVQNENIDDEKIMTIICNKCYATKKKIININFTFSEFLLTIIHGENYKNVQCNHNGKYNSYEICFKNIKIIFQAQQNYICKIASIQNEINVRDNKDSNIIQRQRKKQKLSKKKNNIKKIVLKYIEKHIKNIIHNNVFYYFPCVCVTKERDHNKFCSSGKIGRRRDIDRSKWLSDMYNNFNIYNIIETFPLFTISMLPMYCSLKYLIYNCAINYYRSKNKHLYEKNREKNKKENFNNSYSPIYFKNNCKKCKYLKISNFSILVFFNMLFIIKRIFCNFYISINFIINLLNKNIFIKSNDILYCLNCISTIIQNNMNQSDENFKEIEKDWEHISQIKPNLQESLINYNLNEIMIRENINPFNDQLNKEYDKSRGASSTSSIQLGIKKAQSEEFFSKLSHNTIRNTSYNKFLTANRDEYNFTKYMKTFTLSYSNIGELNGILNNQRNKEAVMYGLKATNDHISYILNDIYKIKDILFKKFIIFKKYKKKMKYYKKKLIFIFKKIYFYAITSLKKNHFTLNMDIFFSLYIMLLEKINFKIQKNIEKMTKLITKSKLQHFYISKSISKRERKTGVSFFFEQIRNLKSNKCIDQTNKTYAKVYKNVDKKTNEKNKKWREEINKLEKYKCRRIKCKKNKDKNKFWMTRNYYKIGIYNNNVNETTDNPNIDFSFVQCYDVYKLYMKEAYYIYNIENYRKKKYIDDINKEENENSSKKLFYAHISKIVDLVRNEKNQKNEERVEINYTIGEKDITKENFVFLFNQNDIANLIFHSLISNEYNIKLKNIYKAEEEKIIQEKRPQICNNKEERNIYSFSIFGNKKFEEEKSGNTTLGNESIQDIIDDKKCKQFQTDSKILKRQKSNTSKRLIKQNKEVNQKYDKDIDKFIKSKLNKLLNISLKNNMINEFINSKNDDCINIVLNDNITVSIYFPLQFYYLRKHLCKKEESFLISLIKSNYINFDHKKKHFIKTYDDKYIIKEINAHEFKSFITRYKEFFQYFSNIFFKSQKSVMCFLFGLYQITIKKTNRKTLKSYIILENIKIANHNSKILIFDIKGARKKKNIQKLIKQNKKSISIFDKNYNLSLNTSKITQDDENDGSDNCSSGISMNLNYFNKYLKNEKKIKLVCKSYKSKNKGEKIRQIDVMGEKGEDLLNSEMVFSGMSNDIQNVSPQKKMHTHNISRNNNSSSSSQGNEQIIHWAYINMRKKMMCGLNYYYKIKLFETSPNVMKFRNMYIVLKMGKGVEIDSQNEYKTNNEINQSKDESNTKKKEMNSRRKYIENIFMKEIIINTKKYLAINRQVLNLKRKKKKKIAQKKRRKKKIQSKNHLYYLKRTLYFLRKKKSFILNKDNLSKHIVKHKNINEEKYDFIDKDNLYNKNLEALNSIEKYNHFVVDNYNSYKGYTVLFDDNFRDYIKSKVINLEYKDYKYLMDSLKEDSDFLSSQDIMDYSLLIHIDISNHVIIFKIIDYLRPYTWDKSVENFSKSVLYLTKGYRPTIIQSEYYKKRFLSNIKKYVSFYIPIHALNKDSVFKITPKSKIKEYEKTTQNEKSFSIITLNKNNPYRKYFFYNLFNIIIRYYGNFHIYMKYFRVNKNNLHMNSFGTDIYSKKNLYIFLSYYAKEMYIKMITEKEEENKQQNKNYYNCNNNNEHVKLYMQNRDPFFMCFNNVDNNSFRYIQKEDRNDNDNKLAIHRDKGGINDQVSSRKMININLLNNNFINLNNTDHKDYNKTIEIIEYLRNPIFPYYTVEQYNFLNYDYTNIRSNHIYDDIFSQYYKNTLYFPNTLNINDKKNSLTDFSKIQSNPFFNSTNNSFDINKYKMLQNIFYNRISEFQITILKKLQKHNFNIESISNYVKNNLYIEMNDVNIHHNNINYLDIYNIFNICEKNFNTKYKRKKHRKGNKKRKENVLLYIPSYFLFSLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMD2</accession>
    <name>V7PMD2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMD2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="1">
        <location>
            <begin position="309"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="485" mass="57832" checksum="B110F37080DE8F33" modified="2014-02-19" version="1">MGKHKHSKDKLYILQSEYRRDALIKKQIKSRNSTYLPFNYCCISLRPFSDPYCDEDGRLYDKKSVLEEMEKSKRNKNKPEIDIKNLIKVNFYKHDNEYICPITRKYFNKHTKIILNKKTGNTFSSEIFKLFPNKNEMFDPITHDTMNMLDLIVLQDPINNKNNINDLHNKFVQKEKEKSQNIQENGAIMSILQEVKKKQMENNKLDANNNTDEDKHSKFKDDYKNEKKKKNIYLYSTNKDNDDNYIEDDSNSENEIKIKCENYSDNKLAQSVTSTIYNATYKNTFVYLSEAQVHDMIYTNVIKNKKNSYVRLITDVGMINIELYAYKSPKLCHNFLFLCEYKYYNKTDIFKRDKDIDIVFLGARKNNIHSAASGFYWRKKLKKYKLRKKIDDEKIINKFKEEINVNSDNDSDIGIKYLRYNDNRHVAETNSYGNIYMFKYYNQKYSNMFYISLSENYTTNNPCIGKGELTQCIYIHKMIMVLIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMD4</accession>
    <name>V7PMD4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMD4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF33">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_20, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764280" description="Leucine-rich repeat protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB60090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="64989" checksum="1B2A809E9138FA0A" modified="2014-02-19" version="1">MLLTNFILYILHTHTIAYKFYSPIQIDLEELHLDSNLIEELENLEELENLKMLSCSNNNIKEIKNLDKLINLSELNLHNNKIKKIENLNNNKKLKILILSKNYIENIDDIMHLKYLKNLKILNLTDNPISNIKNIEEHIFFSFKNIKYFNNKTLSTQDKINKLSLPCDQICIFDSNNITNDTEQYNKNISEAYLCGIVSLPTTLFDQKEEPSVFRKIKNYLQIKDNFLRDIQNINLKIINKILHLNEERKKSSNSFEKNIENFISENINRHAQKYTELRKRSKKVISTILSYLNIPKGINNIELMKCPDFYKNKVQLNENTTLSDELVIKLQNISKTFHCNVMNNSILEMSTSANKREYEENYEQNNNSKKGNYIFIDHEKYNIIKSYLEKNIEENYLLKDKLISEELMNVVSLNNFIENFKLDISKIIKDINDSISDHFKNLEELDDIFNSKIINFFSEVKNNEHPFIVLSDDEINEYYSYKGKRSNILNNLEDYISSNYNKLGNFLIEEKKKYIFLKSRERILEIGEIIDNFNNLFYSYLCILHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMD7</accession>
    <name>V7PMD7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nmd3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMD7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="2">
        <location>
            <begin position="246"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="775" mass="90852" checksum="CE028A30CA626066" modified="2014-02-19" version="1">MVSFLLDEDMKKGDYFTNNFPEKILQKNNTNDFANSFEKKVKFEDNINSFNYASISNNYNEKEEFYFTYDKPKDGITHYYKDCKKDSPYEIYDKREYEENDQKTKISNGFNVKEIKSILRVNGQINNLKNGVNYKDSDSSTNEGTDFDGQWGEQSKSIDEETNNNERVNFEQSYNESLKNYMSSSFVDMLNTIQKNKENQTNNVDTSNQLHQIKNEEQNVIDPSTNYQDKDFSNEIESTNRRIIQCILCGDNILANNSKMCNNCLLQNIESNSMNINKDTYLIYYCRECKRYLHNKWVYCELESKELLALCLKKVTKLKKLKILDSKFLYTEPHSKRIKIHITVQEELINNFISEMEFILHFVIKYTQCDDCKKKYTPYTYNTCVSVRQKVDHKKTLLFLESLLLKSQVNENIINIVSNPDGLDFHFLSRTDALKFCDFILSKTISKCKNSKHLINHDANNNTYNYLYSFSIDICPICKFDLIFFPKDFSIKYGIKSTFYLCLHVSIFIILVDPFGSAKSVYISQEKYNKYPFVALLNKSDAKSFLILNVEYINTEENSKKINTKKEKNIKKQKKKRPNRDNSDISDMEAITNEIFNEQINKLKRKTKSIEDSEQNDNELHKVIEYASSEDQSYHTNIYQNSLADTKSCKSATRKVKLEKLVYAYVELYDESNGSTILTKTCNAKHLSPGDYVNAYDLRKHSFDNDINLHLEENDNYNIIIIDKVKSKEIKKIEDELKIQNNNIETLKTINDEDIFNRIVHNNCLGLEKLKLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PME1</accession>
    <name>V7PME1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PME1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="271" mass="31926" checksum="6F4DE645DBCC0850" modified="2014-02-19" version="1">MAPKVVKKTKNKLKAYDLDESKNIFLYVYEHQLKNEKINWKKAEELKITRHSGSSMRGHYVNSIKNEISLYLEMYAEEVAKVFNKVKKWKKDEKKKILLFQNNFVKQKSNISLDRLTKRKSTNYNKFNSLIISKAFSMVSIKKKMKSNKKYNFLTRSNKDETKKKKTAISINTTNKSSDINKMTIRKNKIKQMKLINTQKKINKKKKKKNTVIIKNALEKPNKNLNTKFSDEINGKRNLNCIKEDKNEDSNDGSHKNKKQKLKDQKRGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PME9</accession>
    <name>V7PME9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PME9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="558"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="831"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1095" mass="128880" checksum="5038B740DE5C9196" modified="2014-02-19" version="1">MENRTLPFNKYQLNNKRPCCNTNGGKLYFFANEPSGNKNDDIFSDCFKVAEEIKKKIIYEQFDAILFLYSKILKENKRKKCASKEIDEKVEEAINTTLEIYSLIESNDEKTKKIYLKKIYSICDIIYKLLVEYTKNENNKQLKEKIINHESEEKEKILKDHCKEESEHIITGGLKKVSEENIAQSRTEINNDSRGNMKEIDKASGIKEIKRILPSFCNNRKKKEYLYRDLSQTNKLCLYGARELDEKFIYNPYKKMKSFKFYKNIDKNLRVNKIDELIERFEKNMKNEKIQVYNFDKKIEKYTDLKKMLLKSRKSITKFELDENGNVKTVTELFQKYEKKKKKNIITFDGYNDNFIKIKKLSNLDELKKVKKKLSEKNNPVLLYSDQYKTSNMKQNKNNDSILNTNLCIDVNKKFELVENSTKDINYISPEKNFKSKTNSMMHCHNNYKNIDKSSKRKDWDKYIANLNFYMQNINGVKFVNYYDDDEIIKHILKENEQKTNKTKLDILNNKTLKHNNVSLHRCGGGLYEYTNQNKINNFQKKNMDIYSESYMNKYEILSKIYNLNQNKKNEIVKYNEEKKNSKQINAFQNNQNRQINNIKKLKKNYNDKNKMCQKNCGCGNNQISNIFLSNCFEKKRQVSEKNEKLKVMSVHKKTPKKKSEPILEKKKYQQSQPFKLDSGNDKIRDTVQLESKIKYQNEKIRNPVQLESKIKYQSGNTIEIKEKEAKLNCENMHLMDKENRTYSIIKIASIISKIDKSKNSIYNENEPNENKTNIKIEGFIFNEHLKDITIKSYNINNKSSKNCIKYISNNRNDNKIIDEDTEEQQTDFIVSKEAKEDSTNDESIKRDEDESIKRDEVESIKRDEDESIKRDEVESIKRDEDESIKKEENAGEGEGGVIKKKTSSLSSSLRKDVNESDSINLSDFMKRENSNKEDNIDDSYGSIETVSRDIQIENDKEETINNYLKCGFFAHVHIILSDTNIITRKCKIFYDNKTKKLGILRNKKIFKIDVSKLMIQEIPSSKPDLAIIKIIIPQNNCRLLIVESNDFFGLQALGDKIGWSPDINGENELEITRKDQEGNAEGMNYKLNSFNNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMF0</accession>
    <name>V7PMF0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMF0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="230" mass="28185" checksum="137A555652F5A670" modified="2014-02-19" version="1">MEIFNDKNNDNKTVNDLNNTVDIYNKYDKDNINNSNNIYKNKLIINNVEDNKKHDDKYVHLGYNKNYIFDKNKNNIYTEDNISKYISEQKMDEKNNFDIKKTYLNLCLNYYNNIDTCVTKKYQKNVQNKKYKFTRLHTCKPHYILFSRCVKFRDKKIMKEIKKMELDYYNALSPQNKYQHMHAYIFFILSFNVFSLFKYEQKKYIPLYVYLFFRSSYLSEFSTNLSYHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMG1</accession>
    <name>V7PMG1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1344"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1405"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1043"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1405"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1449"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1464"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1475"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1532"/>
            <end position="1547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1627" mass="193281" checksum="05A45FE8E9E5941A" modified="2014-02-19" version="1">MMKNNYLFDNCISRNSEFKEVEKELKEFKIQQNETFDFYLNSIDDLLDKVQQVKKNLEEKIVKKEKEICIKKEKEICIKNENDEKIVSNEIKNKYDIKELIKDVSGKNLTEKICEENKRIYNTLLFSYRDIISITKQEVPEIFQNINIKKNIVLKLILLHFLQNGDFFMYYILNKEILEKRKMRRMEKKNKKKINTHNASEFISGDNKDLHIGINKNSTLYNFDKINIKKNDIKLEKNIDEINKSETFSNLKNFKVFKKIETYNKGHSNSYVPLSNEGVENNLIYKEKEFNNIEWDDRKKEYLINGKYSILLNNIKKCNFINKKNNDTLLFYELKKEYISKIWYENNYEQITFEHALIRKEIFEGYKKYHTILYNIKNFDVSSCIEWYNLCNENTKKKYHKLIYFLDCMNYLISSKENKEKALTCLRNLMVNYNENKAHISRLSSFICIGSDNLLFKDMFLNIHSQAFNYFKQAYNEEGINIKVYKKNKLEKCVKNNFLYYNYDKIPDKRNKKIIKRNNERKNNSKHNVKGIKINKSHFNDEENRCLLATQGESNVLVVVPILTNNKKIKNFENIKIVGEGKKDKKKKKKKKNILRRSINKNKEMERNKNSCLKKNKYTYVYQKIGEERKHNNRLRNGRKKSYIFCQKEYPLNIKIDHNNNNTQLVHNYMYKGKEYEEIMVKKKKYIEKLNKEYNLRPLCESYIESNIDKLFENKNKLSFLDNLYNYRCENNHSTINLIFKKKNKQNEYERNFEKRQDIIDVHEKLEKGWYINICSHTKDMLSEVHSDHRQKSCLEKIYKNKLDWVSSPNDMLRDENEIYLYKKNEMDSFEYYNRTNLYLTSKILNKTSQFYDDNTTKILHNTVQNINSGYHAKCINIRDDWNSNYDINLLHCKYSGDGNSINNMLPYFSRFKNGYFYDMTRNNNNNNNNTVNFLNESCFIKKPNELKRKISRCKFLTNFSKNEKIVDGIESELEDEKKKKKIKNNHDNLLSEREDVTNGEDVIDAYGNIIDSQMCKPQILKKESKDCEDEKGNENEHLTLKSTASSSSNNSVISPFSDNNTDSDSEFGSKNAYFCSSSSSDEGEHKDINKLKEKNDIIREEYLKKNTMAALSNKNNTQAYSRATLAINNTRLAKTSIDVSRILLTHVLTNREIYNLHNSLSRTNSNLELRRIYLRWSKKKKKKKENGNKRTNVSKNKKKKKEKNESYYEESNSNEKDNKKNRKKSKNMKNRKRSKSHDIKSCQTGVEENQSDGKKDKKNDSKMMKEVKKFEEEEKMEKNENISEINKNDDKIKNYIAVSKMDLFSPNSEKNAENSQCTITITPNKKINIIEEKLEIQENINKVEEEEKEMHDDTKTEEVIKRENDETNENVDKIHIANCETKDVDKSTGSISNLEENSKIIKKSNNECDIKEKVEKDETPDEGTFYEATNLEPTKKDIIETDGNNNNEEEKNIVLKGEESENINKNSGNTDTENTGKDDQNESKEQKEKTLKKKKKVFFGSYKKNMKKKNYIPNFLREEKMGKKNKRKKNKENDKNRNKKNKESFKLEASLKPSLDGRNRCRKNNTYSSMDENESKKDKNKISGKKTSRKETNLKNKKLEKNIVKETEKKVFIPLRRYVTHSYIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMG4</accession>
    <name>V7PMG4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMG4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="55977" checksum="28416028E93494A0" modified="2014-02-19" version="1">MLKGFSKVESINNNVTKEEMELKMCKIKREDSSEKDKTSDYGINELFESGDKICDEVLENYENVEKMKESKIYHYEYKYNQDINLWNKFFEEFCFKIFDKIIKTSNKSKKVIVVMNMFIPTIIRYSLCKCLIENLNYHSISYINDLVSPLFLCNCNTCLVIDLGYLNCRLLPIMNGLPLYHHYTYVYNGGFYINQEIKRLLKEQYIKGKITELASRKSTYESGNFSYVDKNMKTNDGNEKDEINMNNYNINSEILINENESENIFRKHLEMYDLETILNGIENISDDEIEAIKIKYCYLKNEETKLISDKYILYKLQNSEIIITPETRWKACEILFNKKNDQNIYFLLSNILDKLNTFEISVFQNILLVGGCSNIKGIVSKIAKEFSQIIRKKNTHTKKNNSCSQISGKNKNTYIEKIENNMNFIFPKISPNLRQFLGASICSSLENLPDYNNEHIYNNVLYDHLDEDVYMTFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMH1</accession>
    <name>V7PMH1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMH1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21455">
        <property type="entry name" value="DLC-like_DYNLT1_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11129" checksum="DC6E04F29A138CAA" modified="2014-02-19" version="1">MEEIGKETISQFLEKMYYNEEKTKIWVSQILDTTLKELSKLNKPFKYVATCTLMEKNGSPLTASNICLWDENSDGMCSVQMGNETLDCILCIYAIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMH4</accession>
    <name>V7PMH4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMH4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="711" mass="84612" checksum="D20C49FE3D8286FD" modified="2014-02-19" version="1">MQNANYQRKRFLEKLKLSAKNRQNQKNDIFKDDYKNMQRILKENYFFKESNNLKDILVITKYLNKAKNIINNIPYFLYTIMEEFETSGSTFQENMYLFVLLALNMWLKKITQECERFISDPKTKGKKCKKEKENEKYKIYKEYLYDIIQRGAEQTEMFNDDKVLFYYPSNMKFNVNTSFLTYHFLYINKNLFNFIKKKIKIKKGQKEIQYNTITKIIEKINYKEKDDSAYMKNDIYNYNLYNEYVDLYSLINLSFKIDNENIYPNIFLIKNYMHEEAKNIIDIIYKLQNKYLNLIIYQDVSIIIQLILYILDNLKMLSKKECQQNFDDYSSESKKYISNIKCNYLNMYSKILFPIRLTFLNILKFVHNILKTHKWNYICTFWSKIKENKFDSHTDTNDTTKHNVIDENKKGLGIKNEENCSENGSENCSKNSKFNYLPLLLDECNEDNCYNFNKKKKKKNTYNNFEANCELAEQANFELAEQANFELAEQAKFELAEQRMLCFDFYKIVNDNLKNVKIEIENKNNRDIYTGISLKKKNKYKIDKSPKANNYMSSSKQTKTKSTNLKEIQIKTTKLKETKLKETQIKTTKLKEAQIKTTKTINLANNYDKNNTCSILKKIKTQTTLTKKGDNFSVQNKALSKTLKSNNPCLSKIKTDNQKRINQIDVQNKPSINYLNNKIVIEKQINFIPKKIEKVGNGSWVNTKKKVATPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQK6</accession>
    <name>V7PQK6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQK6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1202" mass="143138" checksum="F9623BD51FCF938C" modified="2014-02-19" version="1">MKKAQNNYTNMQKEEENNILLKLNDKPISKQLKYKIAPEYFLLNRKDENDKYYMVKKTDCIENKRQSLNIKHTKIILCEDIKNRANSLNYGSGYSNIDRRGSNNISYLMKHNIPLKNYHKNKGEQKCTHREMMKNENKDQIKNEPNKNNGIFSTLLNKNKKIIYSDKKKNQFFFPKKKKDKRQKEHYKSNFAKKNIVNLLKKSSRKLLGSGEKVNILKFLFLKIKKKDDQIINKNNDLLINLKKDVSTDSYSQHKDNSIPLKDKEDKHVEKKVRNSFLKSYNEHNKRHSKNKIKIISNLLINDNNTKSCRENYNNTKERMESVSKITEKEYESKKVSSKIMKNYFSRKDNKKKEYYEYGMLYDERDAEMNKIPFISRTQKMRIKPEDIININKIKKNNSKNNSEKNYAKNNNSNYNLDLLEYCLLDINIKRDDFLNKNKRNLSEIIPIKRNKNYINSYDDIKGKSWEFVKKEKRGKSDNSHLSIKNDHYDCLYHGNIVLKKIPKLTNGVKNVHLNEECNTKSHKKYNRKKELKLFKYKLNKAKINKQAKIYKTDEVHEDIDNNKIRTIFIDEENDKKWNYFSWLGEEKNNSINHRRSNNYIDSSDYKRNSKELKYCNKNGGLNNNIKKKYESYSDSNFTYDKNKIKKQRKNVFQYIYEKNKKKKENQKGLNKSETQSDNVKKKYIYPISLSINKDIEDSIRTKGNATKNVDKKKFFEKKNVKIQNFITKDELFDMCRKEENCLKNEEKKSDKDTTKSDHFVKTRNLNTPYKLLDINSKDKYGGNIKITEKGIKHDIRKDETITPEYYILSNTREIKNEKPNGNMKNKSINEKNVEIEKCTNSIDQKINNNEEYNKNSSGDKVNNETKNTSIIEKGKHNGLKISEKIPDLLNNENKLITKINKNDINSSRYNNGKDDKNSIYDDHVSYTNLEFNIKDLITSVSKEECDVSNDYKHEKRKKNYLKTDGVTIIDKCKENAKNTNKRDRKKNFSFYFMKFRYFRYFFLEYKKKQNNVIPINEHRPNKVFRKKKKKFKKISLLNLYERNKILQTCANNNYMNTNKEHCNLGEFLLGEQKGKNKGRKTVVLDLDETLIHSSLRNDKGNSFRINIELGNEKCFIYVNKRPGVDYFFQEISKYYEIVIFTASMPKYANAVIDKLDVNRVCSYRLFRESCTLWNNNYVKDIRLLGRDLKNVIIIDVRIKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQL0</accession>
    <name>V7PQL0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1528" mass="174774" checksum="00D7F11A56B792A4" modified="2014-02-19" version="1">MNPNNKNFASSQVNMPRNGMSDNNHQNNKNILNSQYGNNMNAFKRNLLENGDDPSKIPLSHYNNNVNFNNNNNMMKGTSNSSPINYSIRNPNFQNTENGIYKTNNNMYSSEYANGSSNNNNFNSSMMPNLKMKNIITKGNGNPVNTNMSNNNLINNMNYTNFPNKLKGNIDDINNKNNYNMINTNNKVAIPNIYRNMDANNNNIDASTIISSNTSSLNTQNGNKSGNLNSVKSIDLVNRNNLVNNMRNMNNSGNVIRNNNFQNVNGNNMNNIYMNMENAKSGIDNFKNNSMNPNVNTMKKQMNTIGVNGSNNTPNINNNMNININGYKEMASFQTLNRTHSHKIDNSSNINNINRRSNTVGASNNSVNRNVNGLIRGTEHGNNNDGNNITNQYYNANKLQGSMIDHNARNIPKNLNLNLNKLPNMHNNNNGNPKYIDNKSPMYNINNNIYINENNGNSENNRNFSNIQRNNKNIYPQGFSEKINSMPNNELNNIQNFVSTKTDSSLVGNNGINPTKIMNCMLPNIDNTANGMNIVKNGDNNNLIIPKKRKKGKDKDVITLSNPTNNLLENNGDNNITINKNTYFNNQNVNNALLGQNAEELKNQKMSKKKQKNNDDNPSKNDGKRKKKMMENNLNNMPIPAYQNNSISSMPNPMTQQTESILMRNVNTVNSATNHTNWAGFPSTQKNITPGTDFINNGEVNGSNNKSLSSYKGANIDENINNNNTNKEMMSNGDQMKVDPKYIWLFLNNEFNDNKTKYAQILPLLKHYYPNRLNDLILLLEKYSLMNLNYIINSSYQLQMKLIKNYNRLESEKSGNTNGNNPMHNENIPIYEGMNSSIYNSNAENNRINNELNMRNIESRNVENTNIDNKLLNSINNNFNNLMYNMNLDGSLGRSNTNEDIVNNKNTTKGKKSNSKENTFKDEGTKKPRKPRVSKKSQQNNNLAPLNIINGTENNISIENLQKNNELKINDNVSSVGFGVHNVNNESCDKNNDPSKITENGVAKFLEVSKNELVEQLGGNNIDNDVNKNTKVRKYRKKKKNDGDNDEGNTLNISLDAVSIDQIQSSPNINENKRKKKKKNENIDNTNEENSTEIQNLLSNDKGNESIYANKIDRLGMNSKEEDIINTQILDSIVSDYKKSENEINQGIINNNECAERDDKNKIDEESGDKENKIEEEINETKKKKKSNKDATKKEKGLRKNKTKKMEMANMLQSYDSINGINYALSEQYNNLYGKKITNIKKLCYPQNNLLAYLKEAGLYNNLLGKTNRINSMNAIRKKYKKFSFCVNKVFKKQNINDIITLNDNINNNKQFLSLFKKKDIRNLKRKNLSFFMDKLDFQKIDLLIIKRIHICMEKIKNTLGLTCVINNVEQIIKILKDAFNDRMKFIWPMIEFSNNYRLDQYFHVLGKNRNHPNSNFRDTRIVVNQNINSLIMYFNQRDIDGRMIEYLKTQMKPRKRKKKNKNKEAFIEDKTTEFFKSINTIPTENATINSAHNWENAQAKANEFAFVRRKINKPTLYTNMFIFSLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQL4</accession>
    <name>V7PQL4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1588"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2370"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2548"/>
            <end position="2568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1707"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2146"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2689"/>
            <end position="2710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3583"/>
            <end position="3649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3922"/>
            <end position="3951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1707"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2165"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2697"/>
            <end position="2707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3590"/>
            <end position="3610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3621"/>
            <end position="3634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3926"/>
            <end position="3948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="4066" mass="489252" checksum="DE896B57F747DE55" modified="2014-02-19" version="1">MNVEDCLNPSPQMEIVKTFELPKNINEIYFKIEKKKDFVISYINEKEKCIYIIIYNIKTNISEKNKLYIPDYINFEKGIKNITSVSLNQNYFIIFFNSNELFIYRRNEKQQNNTHTEITESQNEDSYITCNFHKFLGEKECSRIKYFSNKSLQEIEKYTLEYINKKSEISSISINDDNSLFLIYSPNFLEKNTQNKLNNNKYTSIFQTFTDGIYKYYQKLENYSFSKIYGSDNINSNNLLYDIHHNLYKKNNMHVSLINIDNNPKNNLNTLLYKKYISTKINPFCNDIINDNTHFNYVTHLYYDTIKKITKKINNLNEKKELNDSEKIKELLKYSKYLNIHEINKNKIKTINKEFDNDNKIEKEFLYMTFLKDLTNNKKSNSPLESYNNIYLCKTDKYYLILQNSEQNYNLILYKFKFLNKQELLLHLFFHSYYDAVLESESFLFNILHQFFIYSIYDYSGRYLESSLLDYQCLFKIRDVFDFLGRAVIYDPFLVRNSSEKIDKLLSLKDDEYNTGPPILTNMNYGEDNNNYDYFFYTLSKNNKINHYSKYINKYYIIEKINLTQSDIHIDIDIQLNKLKNVLFSALRLIYYILKENENYDDIFSDCSGKNELDDHLFINTITQNNLKTSKHHKNQNDVENSDQNTEPNHLINSDKSPIWSENEQEEKNEEDEKSEEDKKMEYLFDLDYKAFESTVEIIKSNEDMKNVLLKYKIELLKQIYKYKAFKYLIRLLETERHNKSCYINKPHLENEKLTKSTSNIANNNKTNFADLLSMFKTRDQHGKNEKHGKNEQCVGHACEGNASDSSYPFSEHDNFHDVTNSDKKNTNIYLINWTKFKYDYTPFDIVKYFLINKNYILTKIFYKYFKSYINNNWQHIFYYIPLNTNIEDFFFLLPRIKKVNILSNESNIFENSLSQINLSQKRFNQNPEPYDEEPQVDSKMKYDEEPQVDSKMKYDEEPQVDSTSKHNSTSKHNSPPKHKPLPFEEKECNINMDPKNMYEIYCSENEFFEFFIIRCMKIITETHLIRSRLLMFVYISVKLINKNNIYKIFNYDKKKKKYTFNSNYFDKYISKSNDKKNEKNTFPINFHDGKEETRGNDIAIANPVNNIKTNLQNGNANNDNVDDENGEQTILQNREPWNDSNLCDGNFIKNKLKIYLKKDNIKNKNVILIYSLFILIKMYLQSKENYKNLKFEEFMLMNIYKKLCLTIDFDKKYISYKYDQENDNINLFYNKIIDVLFNYKYINAYIMESKKYYYSIFEDYIIELYLKNPTNILESIYYNILYTSEQIYVIFCLTTLKQLQSKSFNKLIIHIDNKNRIFPKIPLKKIENVSINNLNYNKQKNKKNAKIDEIYIFLKYIHYAYRHKIILNDSYQFCYLFLIIFYKYIKTNLIHFISIFNDFYNIFPKNVTIKPQPYYLNTHLDESYNDKNEPIPTSTHFDINSIFKQNENDKKRVIIHDEHLEYIINSYHDQIEVDGQSEQNETEERDGREGRNYGDEPNCKLIETYLDIFEKHLNALDIIKFLNKETNNDENKLNINIDIIINSKNNMKKSILNIFKIFKYIILYTNYKDDNFTKNCLQVYYNLFNSLHIHIFFFILFYIILFYSNDFKYLYLFIKYYDDHYPNLKNVSNYSKIITYLISNKAKTITIYHNFYDFYNFLKKITSHTDIFNHVAKLKEIVLCFKTMLYIQRLLNENCKNCKNYENYENDENDENYENDENCKNYENDANEDDDKNEAKFRTSSRCTKKINNQTKYNENIYYSFSKLIVDPYEKSDIPKKFNSLNNVDNVKFDYKNINNVGKYIIYDNYINIQTEKNKFKIFKNVIEYNLDICYNYKKIIKLIKILKIKKSEQLLDSILFVLSIIISQIEYENNQIQKNIFKTNFKINNIKNESIVTFYLILFVIFSKNHKLKKYKTCIQNIIKYYTILIPHHPQYLYNLSLFFSSYLCIDYTFLLNNIYKYVFKKNKFASTLNHASIAINDSNIATNDSDNTFSNFTTIHDLFQETSFKKNKEFSFSPQNYKNPDPPIYTTFNFSDNELGEKAEEIDISFFESTFFDNIINEGLYKHDDISSDFEKSEKKKTQSVSSLFFRNEVDTKRETIFNSECMSSSECMNGSECMSSPDYMHKSECMHKSECVHKSECVHKSDMEEDDQDITSTDDTSQESESDKNKYKEDSDNEDNLNHLKINYYKKSLNMDNFEKNKIDTQNDQIDYINKSEANYFVENKKYKKIFINNILVNKIKKYNISKSKTNYIIKTVNNIKHILKKTKIENMNQDYNETFVENFHFYIDQDKKENYKINKKYYFYKSLFYNNLDVAFLYLLQIQDDIFIYNFFKHILQNNSILIIKKISIIDAFIRSVYRVKKSNEINIFLKKLIISVSIIRYLLFHLYINKINKIDIKKLYFEDNYKKIIVKRLYKNKSEHILELIIKIVDMFKINLEQIKYNFFIKNKYIICKIYNQVSSFLNNQLTYQYQQNKMSHIDKDKNVSKQSNNKFQYIFEIEVEKEIMNEIKKQNSNHFLLLYILKKFQHLSFNVDFIFKMLLYIYQICLYYICPAIYFIVLSSFHVIFDKSLSYIHQHLSNFPKKKLISTMVNIRTVFFYFKNNLNYNIILNNSLTQIDSDQNIFSIIYPQIASKIEPTAQEQEQDHFNNSMALLYLWNFLSNFDSEISSADFDSPPHRFTFSLTPKLKKSGKNENSENGQNCQSGEDSPKRDHFSFLLNKTNISPYLYDLDFLIKYLGINFYPHIYMHMPDYDKIKNMININEKEYLKYYLFLSILEENEINPKMCKQLNMYSILTTNDIYKYFYSNKKYINIFIDFFIYYNIIFKFDQINNEECHKFFENILFQNFESIKNRIKLRYTKWMFLDKYKLNKFFIFYNFIHNYNIYNQKAFHKLIVDNIYEVDILLLIFFSIQNNLKIVKYVIFKIIIIIFFKNIKINQLTLQNLILSISLHLEKYQQKCNNNTLPEFLTRNGEEDAQNVNEKNNLIQNEQGESFNKDIYIDPRMCGMCDVENDGSDELADTDLEKSDNYFSENIINDMSKIAEANNLFYQNSNEIKPKLNQEQIKFFLEKNQNNKIEDIQINTEILTKFCLKYINLKYIIKKWMRDELKSILFISLDQNSNITSLFNKSKQIYYALSKINSKNIFYYLKEMIHLILKTNRKISSKQIYQRRVYQFYHFFIIIQTINYLKIIKNDENVDNYIQIENEINNIDTKKTIIKSLFFILLIKIVNIYLPSLNKLFFIHEENYLCYDKKKKNIKLKCDIKNFIFILFNFIQTTYSKGYEFIYISLLFLIEYCINLMTKNEEIYNNPTFSHIFIYKKVQNVVNKYTQNYILKNEQNNDKHNDDIALHFIDNESYLKIKNELSKIYLKILSNCEKYMLLVCKIIIGNRINIHDENILLKNSNIDILYFFTCNYSHIKKNKQNILSSQDNKKKKKKINFFQNKNQTQNTIPIDIFNKNIYKFIQILLVIINYNIVSFKDWEYYETIKQIISDKEWYKIFETQTDNKKYSSISFLCYLQNYKSNITQSYLEGFNNSSFSETSSNNFDKTLKYFFQPKNILSNNFKNDSLKFNDSDSNILSNGYKKETLPATSNTQHSITDVEPKQNQPAKNDEHDENVENVEHDEHVEHDENHQNCQHYQSEESGDGEFEFNSSLKTDAVLNKYGKGFLSSYLNILDTNKRSQKDIKHIYKKSKMINLLKYSLHILDYWSIDIADNDSQHDEESEKKRKGRCNKINHNYQNNLFKKSTELKAEGKEESLQLLIFFANYFYFFQNYIQYKIILKMYINKNLSEANELFFNKGRMWNWYLNETKIKNMIRNYLINNIHYTNLYNSKTNDEFLNLINKTNYKYTHISNTSIQISEKESLLKDNNNLLDHTYDCFYLKNYHLNKFNKHFIRSLQIQYYLFAKYTASDINMSQNGHSEIKSGSSEIKSGSSEIKSGSNEIKSGSSEKCNDFPIFLLNILDIYKNTTDVYDFYYQLIIHKLKDDDKLNLKKIQNYWNNLQIYFKNKINNYDLYLMLFYYQYFTFQSIQNFNSSISYLPKNEQKFILYMWIYSTQNLEKKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQL8</accession>
    <name>V7PQL8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQL8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009991">
        <property type="entry name" value="DCTN3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07426">
        <property type="entry name" value="Dynactin_p22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB61901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="237" mass="27990" checksum="28CB951863A695FF" modified="2014-02-19" version="1">MELSVKEKKKLLENLKHRMLRIEKVIGDITFYDKNNPLKKNNSENSFDNKKNNLIEEFTQSSNQFDDFENLDEYKNNLDQIKSSLQNLSIDFCDEKKKNELIEIVKKHKHNNSISVHICIIKLVLEQISKDFLNDVYNQYKEFYIYIHSSSILDVYSAFEYKRNIILSHINFMKCYSSQIKQTLELKDYINSHKISETDSFMNRLNEIEAKNGILFSKISAINASLENATYKYALIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQM1</accession>
    <name>V7PQM1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQM1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="477" mass="55970" checksum="FE621FC68C48C24E" modified="2014-02-19" version="1">MDKLNKEHIISINVGGKIYMTTLNLISRYKNSRLYEIVQEKLTNISDLPNDINKREIFIDRNGNRFEYILDFLRDGVLICENDITVLTRILIEAIYFKLFSLMKIIKKKINLLYSNMNNNVNKNIFKRIISTIEKNRKEETNKLVKLSGIISNYNELKYFNLKKKKKKSYITILNNSNIINEINQVNKDIEQVFARPDKNDSTNLLSANFQKNESTNKLNLQSVTNEKERKKTNAYKESYYDTNINSEKNMNSQEKNSNIYKKSESPNFEISNKIEREVSKDMLNSNLKNDVDKMDSHLSDTNSLEKNEKDIHANSEYYNAKTIGHKYVSFSGENDIIFYTNSETLSDEEQFGNIKNSKDEKEANSNSKNISRLRNINVINNKVSELNYNNYIGNNDYIGYRDFENEHNNFPNYINSVCNKKSTYNYNNYEYNNMKNNVRNPIMVYSEIDDVEETSNYPIMPNINLGEQIFSTTVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQM7</accession>
    <name>V7PQM7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_01209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQM7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="288"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB61280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="425" mass="50629" checksum="CACADE5C97F0BF7B" modified="2014-02-19" version="1">MPCYDKYKDINILSEEEVDLLKKFHDMNKKEKFDYFKENSMIVSVLFNCLKNDFNAHLIQYVLTIFYEIIRNDGSSYSYILSILDCKEVYSHLMKLCTHNDTYITDKSSFLLSGSFCYNNNYFTDMDIRNFILKIDFFNVTEEGKLDIFINILKIDEYRKDIYELEQFLTILNKNLDIANNNANKQYKSVFCVWLLTFKDFFIKKLYKNNIISVIINLFKKCRVEKILRVSLNIIKNIIHMDDCFEIIVDNNIIQTLTVLQYDKWRDNDIYDTIVQLLHKLDQRVKNYSNFERYCHELSNGKLKWSILHTEKFWLENVMQFEKDEFKSIQQLADIIKKYAHSILQKPQSNETKEEIDNVTAAVACFDIGEFARLYPNGKKICQKFKIKENVMLLIATKDRDIAREALLCAQKIMLNNWQSISNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQN3</accession>
    <name>V7PQN3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQN3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="286" mass="33992" checksum="9CF98F44DF7A5827" modified="2014-02-19" version="1">MLGKRKVDNTQAQKKKKKWVEELDSDSEDIDLDYLNNLDENDKIQLEEVSDKEDELLDQLEKEENKENKDGSQNMEDTINDGNDNKNKKRRYDWMSSDDEDIPSDDEEEDIEENDNIEDSDNNIENQKYKNGKEENNNDIKNNYSNPIDVHKKEINKIGDINDIENSTNEIIENINKYSIDQIDIKFEEIEHIVTYVYFHNIHFDCMTENLVTFLENHTKNKIIQINSDKSTNHAIIYKYDEKNDEKVVINKFSHYGKLFVHVKNYQDVLRLLKLNETQFMGRIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQN5</accession>
    <name>V7PQN5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_01569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQN5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="8">
        <location>
            <begin position="33"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="9">
        <location>
            <begin position="950"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="812"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="812"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="849"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB61744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1238" mass="149203" checksum="A55E35059E35D4C1" modified="2014-02-19" version="1">MPPEAFSCILLCICYAFFFIFFYFFFFSIFQKYVYISNRPIYHSYETKTVLSDSEIIYKNRVCNSFYFFYYFNKIGNDYLLAVLNNIRENKLINEVIQLNNEEIEFCQNNYEMIANCIHENDISNNYINTIINKIRNNLRSNIKIFVFTTQIYTIFNNKALLIHDKYLYRIVKGVYKNFENIYFLICDKSFDMFYEKFKQFYCKKNEIIEFKTIGKIQGKYLNDSTYYNFINNQENQFLLTNENKLNEYFGSGIVHIAPSHGFIDYNLYYKNNKLKKIYLNKLDYENIKNKDKTHKINKVENEDTFFDSSSQNVIDENDDLQEEYNKIIINKCRKNINLIKKYEDKSSQLLILQFLRNNNYDCKLLNQEKYNKININQNNYHLLFFYAFYENIFFHFPYNHLYPFDWRSHTSVQVKSLLQIYIDIEKIKKNKYFYKNIKNINFLNNNNKNYLINTMKDRNDWCISRQKYWGLNIPLKDIKINDNQKFIFKNQIMDVWFDSSVSYLYVLYMCKHILYNIYLKKILSSFKKNYNYNLYTNKFIQKKKKSISHWYVSNKYLNIKTDTQSFYINDIYKEITKDKNISHDNNPILNETNLLKNIIEKKKIFDPQKNYKNIIKEIKNKSNYFKIKKVDDIILFNNKNKKQMYKNNLSIFLCCEGIDQIRGWFQSFFFIYFILNYINEKKTKIKNNDNDDNDDNNDDGDKNNDDNDGDNDDKFSSFKKYLPIKNVIVHNYVVDYNNVKMSKSLNNVISPRDIFIGINNKPQNLMANHHNTYIKMENYQNKPTTHSPIVQNSNDCVTSNCQTGTLVDKSGDEQKWDQKNEQKCEQKCDRKSDPKHDQTNSTLDINENNDKDKSNTNSRKEMKNLKSQFDDFTKNIKDKKKFNADIVRLWVCCYNFLDRNISISYDILENINKYIYLKIYNTLKFLLNNIYDLNFTEKKIEYNKLQIMDKYILYKKDCLIKNCLNSYKNFQLQLLIKYILNFIHKDLAIYIDYSKDRLYIHEKNSINRRNCQKIFYKIIIDLLRILAPITPHLCEDLYQSFRNLKNNNLNKLKKINGKIKSIFLLPFPKIKNYKQVNLDILFLIKYYIHKQLNSYFSNSLLAIVYIYCDNDEILNLLKKFLKNVSPLDNFNNYDDLRFVFNVSNIIICNDLSDVQKMDENYKTYKIPLLTNIMNSNTNENNISDDFFQKNDQKQHDFENISNFDEHTKYANLSIGIKKSESQRCSRYLAILTCLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQN9</accession>
    <name>V7PQN9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQN9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB61062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="744" mass="88218" checksum="EEE5430FA89C614D" modified="2014-02-19" version="1">MFYGTNSITGFFLKKIRTVKRAKNNEKKYICCSYIRNDISIEKDNICRNFQNIKTQACISLKYNRMDANVEKKIISNYNVNIEEKKNSDNSSEYIYDDNKNNECVIARDKEKQKNVSDNIEKEDTVLNSKIPKKDTINKNHEHILESEYNDMINEQNNNINNLSLGKCISTQKKYIYKFEKFSVFSFNILANSLVDYKYNNNCASVMKWMNRKKLIYKNITNKLSDIICLQEIEKLYFIELQEKLKLLNYKGIFLKKNKETCKDGICIFYNTKVFELLFVDKVIYDKSIFFKKWHAGLIVALRNLKSKKIEYYDSNKNGCNEQINDNLKKNNNNFVNDAHDIIIVSNTHLIFDSRHGDIKLYQLCYLTYRLVFMINKCIKYIKESVKQEKGDKGLIDSSEENTEEHEKDELNDILKPAIIFCGDFNLTPNSLLYYYITNRYINLKNVNLKNISGQYLMFKKQLYIYNSLNGVKIKNIFDENILNDLKYEKYNNLIENMKKESLFSFYKDENILNSEYLINSFSKKKNNLKNFDSFEYTFKKLKNKSSEETYEDVNSEKADSKINESICVSKQEDSVSKFNEIFDSVDTDEKEKNKPINYKTYKYNEKTIKENEKPNVEMHENTKMMDNDDQNFILYYPLYLESIYNGCAQNNVEEKCYKYDDIENLNNSSTHLMIRNVPFTVFHGKQKGCVDYIFYSYKNLKKLSYTNLPSFEQLEKYGCLPNKKYASSDHLYLHATLIRKIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQP2</accession>
    <name>V7PQP2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small subunit rRNA processing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_01573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQP2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB61749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="40054" checksum="8E450C4E5115777B" modified="2014-02-19" version="1">MVENVQTNFKGKTNDGKRHNHYIDKKNKTKWNNKFKNKNKKNNIKDRKNDFHKTSNNSNNSNYTVLGEKNNSYDKKNYLSFNENENWDNQNYSYINDSDDMYIYKNNEESDIEINSTKINNNSNHSDSKDNENCINNKTTDIKNVNYLDYIASLKKGSEKDGEKSGEQNEEQNCEKGGKKGQDKVYNFFLVFSPLAITSIKNKSSIINADEHMNFLEKKLENMDELINITRNYRERQNLQRTRDNIKNKLDNIRLDILFFTLLSLRDSIINKKKQIQIYIHTINGLLIYVSPLFRVPRNFFIFKKVMLSLMKNNIITDENKNTLLKILPYSVKYYAGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7PR00</accession>
    <name>V7PR00_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="959"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1602" mass="191014" checksum="6906C880CF76C92C" modified="2014-02-19" version="1">MKKTNKKDTLADQGEKYREKNELNTLLEYLKKEDEKKVQWTKNLRMEPEKIKFKTTTKKLNIYNNISKENKKYIFDKIFENKYQNEDKEKNSEDYVYVKNRDAKKEEYQETVVNKIKNNLEFFLSNFAIPLSDDLYVQGNPIECENESDKLSSEEVNCLDVLEKEKNPLDKNKSQQAYSKQENINNTIHYDEMLKVNCSYINIENNVTNIVNKFIFLQNITSSTIIYIIYLKNKMKIKNDVLHFDKKRNYNLFIYPKTGYIKPGETIKINLNFIFDSFAYSFGFIQIKYFYKNKIFKKKIYVSINPFSDILDTFTKVGKITDNDKKKTKKLIKKLKKKYSNFRIPNIDSVTQNKTYFPNQQKLENMIKCIYFDYNINNFESILKKRKESLENIPKIIPKIIPKIITKYQDDTNESNITCDEIVSNNIYQLNLKNNMNFFFYYIKNKILQHIKESCNNNNIPLLNYNANDYVNLESKIFNYKLEIILNEINQIEKVEANNEILYEPLYNYIYYLIYFHKTRECINKNTDVETIFTNKCDDVNLKHFTKTSKLQDAKLSRNIKTNMFKREEKKKSEMKEAIEMKEATEMNEASEMNEASEINGVTETKRTERDTLNKTFESILLYDRREKYFRCFMNHIYLQNKLNNSYIYYFYNYFKIIKFINHYFILDKNSVDSKLLKQNVFIYMNSNLYNIIFLYVLEKLGSDFFSENYSNILNDSNLFYESKIKDIINKLTELFWDYFLSVILSVKDGTKNIYAYFGDIKKNEGKENLFNLFLILYLKGFVSKISRTHYNIQILENKGDIIKYVDNTFIEADACRDKCKNDDEKDGKNEKDEKNEKDYEQNYEQNYEKNDKHGEKMNSDIAYTNLDLFFKNNKIYDEICNSICEYKNNIDSDHLENNQNMLKGNIIFIKDQITFSQIIYEANKNKIQINIDHNLEKLKEAKQNRQAKQVEQDKQSEQAKQNEQAKQNEQAKQAEQAKQNEHGKIKKSKKNKNREKKKTHTLHKEDKHKEGKPEEAKPNDIELNYTNFHFFKMFENLNIDTCIIDDKKILKKSEIEYNHFYSNIFTWLKYKIPENVKINWGYIIKKEMYILLYILNIISIEHINFLFNHFKNSNILLYIEYLKSNANHFLDVFKNVLQFFSMENYLSKFIFEHNIPLSMHYDNLVINKMEFEKEKKNETLNFSEDIYKKIREDWEINKIKNEANEANIDAKYICIISPNIKNKILNFTNLNEILEWVKLLNIIIFLNISDVYISGDLFLLFLFFIYDSNILKGQICKSNNDIPTLFISPNGSTHTCQNQSGAENGTENGTENEIKNGVENGTDGGVENGYFKIIDTCNIPENILFLLKFCIFNIITQYEKYKIKIHFPHDIYVNYNSDTCQNNNSTIYCLLPYSNYSIMIQYAKDIFIKKYNEDINKAMQKKLKDDLKNIIINSDSNQNLLNDIFNDSNKLLKCKNGRNCQNCQNEDATKLIEKPKVFTSILNIGSISINNILKNINKQNKILWLCGSFEKNINDDNTNSMKIFNHILNILKNEQTNFINIQKDIPFEFYANNLLILNKKIYYLYIYHVPKELRLNFVFNNYHILTNIFDNYSYFISQKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PR09</accession>
    <name>V7PR09_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PR09"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37750" checksum="B2AE37DD5EE495CB" modified="2014-02-19" version="1">MSALSNRRTNAGIKELLNFINLNFPANNDVIKKIEATDEVNKKVNGEANNEVNVEVNVEVNGEENGEENKISTIEKELKDEICKANSEHNRFVPLRNIIKNFTFIKFNNDNDLNPSDIINKTFMLATNKKEKYFFRNICKIIPLDTICKPHLSPFIKTLLPLMRKHFTDGKCMEDTFTVNYLLKIMNVPDEKTDEKNEEKSEGKNDEKNGEKSEEKNEEKNEGKNEGKNEGKNEEKSEEKSGEKSGEKNEDSSGNKKSWALIYKCCNTKTLTKRDVLKVLDNCIGNNYSVNLTKPDMAIIVYVTEIMCGISIVKDYASTRKFNIGSFNDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PR16</accession>
    <name>V7PR16_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PR16"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="958"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="991" mass="117181" checksum="C1B07BE011BA9570" modified="2014-02-19" version="1">MEKNGISEPVGMINDAYFCKAIKTELKKLRDEYLKRVKNNFLSDYIFKTEVFCISFFFIPLIAGRIVLQDNNIISPHFLTVLFLLIAFLLVIFVLLYFEINEAQNREFVKKIEKAQNILSVRNILKNKKDDSHFNYLTTSNFIFILRNNKWELLPKNLLIKNDVFLLHDGDLIPCRCVEYNIYENVYGKEYQRNEVFMAMDKYRVSINIMTKYSKDEKREYLPSFHLYAFVSYDNASIYIIRKCINEKFDKSKSSKSKENLRNVVLEEKVHVIFIYIWIFIFSISTALMFIYVSNLRKIRDIPQYLLIYWLAYTVLMSMSILPFIHRIFSELIYGYCSSLSMSYENYFKDITNYEKKSFTSSFDLSSATENSSFVIEKKLALFYTLKSIFLLIFKGIKINKCYLNILSDCSVLCFLDSNGILVNTNHSVKEICIYNQLNNKKNVNDNNNNMKKIHNYYNNILTIIDIFMDNKSMYAYQRIQNIKILHSLFLISYFTQLLKYIKNLDDFQNNILNYMNHQDYNHLYTCMCDIGNISYPYNKFSFRMLFFCIENKSDYELYKKKNLELKRNKKGKIDGEIPYYVDKNEKGNELGINIYDNLITRDNFVFIFILYEKKKNKYHMFFKGQLDALVSKCMFYYDGKMIKKLKRRKKKVLKILNMQWISSGLESICFAYRPLSTDEINYLKTNFTKNIYILTINKRKVYNIKNFYNEPNFPCKENERFLSHLISTSIFIGNSAVKILTSNDIQARINDFYDAGIRFVYFSNKDQINTRNISNTLGMETNWNTSISLSLNDKSSFRNRDGKVVIPSGINNIKTHIQEIDDIPLRVSSYSGCNQFNTAEMIKILLENNEIITCVGNSLNCCNFELYKLCNYSISVLLPYNNICTDCYGKKERSNPFGKPAVNKNPLIAYSSFVNSFPCNLTIEKNILDLSENIMELVYKLLKSSRIYKKNLSISMFYFYFYYCYLSFLLFVINVFFLPPLISVKKNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PR19</accession>
    <name>V7PR19_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 61 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038884">
        <property type="entry name" value="CFAP61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178:SF8">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="720"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1371" mass="164526" checksum="A8E002E1504D89B4" modified="2014-02-19" version="1">MNIIKLNYDSSVKKTEREYKKVVNLSYYDIFLLLQNIYPDIFKTNEIILLFLFLDLYEIILVTESTIFDCVSFKTHLDELININKNYFIYKYKHIDWLSNLRDDDKNAYSLNLFVLNDKYYSNSKEILLKIEKICFKEVDYIIATNNERGYIPFILNYFNMIKKKKKANTLESLYILNKYTLFLPPITDYMKISDIEDVQNFLKNCDSDKKNEIIHTILSLKKYCKNKMDTEKTVYSSDAHIWELNFYQAQNYYIFVSRSGNSIINVTSGRILNNLDFYYKDKIYDFKNIIVQNENKNTKHFLMSFFSSIIIFKYYDKNVIHNILRLIKACSCHVEISDNRFRDVYKHFKILKKKDNKINIIKKKKICDNKKCMETYREEEKKKKKYLIITKQMCSKKSINIDNNLVFWGINDICLYTLYKILKNNEYIFNNIIIIIRYKNKYLCKNVIDKYNNITNVSLDRLTIYNNLKNMMVSDRIKIIYDNVYNIDRENKKLELSQKKWIHYDYLFLCFDKEDITTYSFDIDSYQIGKKKNFNFLELSNHSLDKNEKLDFLVKAKDYQKYENCESCKNCESCENCEGVKKYKKKKNENCRDNELEKEKEKEKEKEKEKYTTSESSDIYDEKIKPKNKTFQINENNEIGKTPKIKKINKGDNPEITIKNENEKEKDYYTDYYTDYYTNYYTNYSTPPSSCFDTSEESSSCVKDILNDGKQSANLKGNNEAKKGMKKETKKETKKETKNEMKKETKKETNKRSINGVFSISDPMLEKHFDEKSKYMKIVKNGVNYIVIYSNNLDILSIINFFLKNKIKTYKLIIICPYNCNKCDRENMKEMKKESVEKDNDKNDGGCIKDYIFKERGYYKNKEDLKNNYLFLNNTNLSNNYYHKNCVLKNIKYALNKIFFLFHLLKIRIIYGQIIAIKKNKDNKLKNIIVRFCKHKKTDQSLINQKNIIFKNFIILPCHILLSSYHFDMNNHLNYILRKSSIVYNQKICLNHNFQTNDKFIFSGGDLCAFSNKYRINKNRELNHEYYNSVEIGKMASKEILKIVLDKCRIPYNVLKLKKKNKQMENCEKKNKEMENCEKMKEKKIENCEKKNKQMENIQNKCDDIFYYYKKLKVFEKPFVYFNKLPCDFYFYYFQASNGDLCKYNDLLAPQSGEENIKPNINENNDNSRQFKQVYNNAFCTDTLKITIKNQPELNEKFNVKYFDISKNIHAQGYYCRITTNSLNMINSFTYLGREKLNFYNLSNLCNLSINYFYTIVKKVQTCNSLNYDILSMMNEEREQFIFYYKFQEYKNKLKEKIINTPHMKESIQLLIKDAYDKDVLKTYLEYKNSNVEDNDVCKNIKKHVQIHLIESIKKNRDLLNGYYMPTCNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSP2</accession>
    <name>V7PSP2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1742" mass="207950" checksum="D93479CA41694A52" modified="2014-02-19" version="1">MKKTNMLLPKRSEGIIKKKGKLFFLSIKRYETTNISIQKNDDNINISVEKKEDIKNDNFISDNKNDGNAKRNIGNDYLIKYHDENKNIIKTTNYILKIHLRDNIFVNQKNNFYNYFYNSYPFIINNYISQVKGNYLSLNDIENENNRNKKPNDTPKQKSNYEIEKLLHTFLYYNKDTKNSLEDENFLNIINNKMNNLSNASELLKWLNKNMHLTILKTGTNQNEELSNKIISKEKTKLYGKFSKLFQNIINHINDTNDMNKKIEILLYLINICNKNVFPQIYEQAKTCLEGIYEKIKGSQKKNSKKGIEQQYIMFLLYKNFLSKNVEKYINMELKKYLTEEISFYNYLKNENINICLLSLIYRDLSFINNYEIKYVLMNLAFSKIKNTDMFVDINNSYNAIMPMTNLQSYTNLSRDNNSYAPILNNFQEGKNNITQKNKKNNIFLSDSYLSFFSNTLLKNNFYTFLKNDYIYFDATNKFNSQTDINNTNINNYVFYNLLVAIIQLKETHLKLCDNMQIKKMKFFLENEKNTTLLNFICKIKNSSYYFNDFIIQNITFFTKYFVKHKINFPNNIYPYILSIYCNLIDNMKNIENYSDIKKGKNLINDSKHIVNYIINEIYYNINLYTLKEYLSLIKCIQILPKKYMFELKRDIYSSRNRDKLNSHSFYNDELDKSNDKLNLQNLLDLGTTKTEKKDEQVQSSNLRSNNSAKIESIQKVMKNNIFPNRHMDNLIKNNFKTKKSVTIISTTDFIGLTSLPIFNELNEDFVLKIRQNEQMKIREMIPNKLSNNANVTSINLDNIYEYIYTFHYKKFVNNSEDYIKNISIKYDELTKDQIINYFIFFTHLNELDISDIYVLINIMNQINVFHPFIDFFISKRVENLLQTKWKNEEINIFGKLSSDITNKNTLNQYKFSDTYLDDYITKMKKINEQDNFKKKESTNNKNNVNLNDDNTHEGIHSQEFLRKNIDNSQKHFNDLNLYNHNIYASNFENINYNYDITTNTINLFLSLNSKYKTKHIIEKYLKFFHFENINLFKINFNYFIQKRNQETYSTTKTSIQSLNSIAMTSKLSDDILVNPILSGMLVYPDTIEDRGSYKIISETYNNTFDKLNIISNIDTKNDGIFCLHPNSQKMDTGINHKIIYDIIESRIKYDINIKNFILNNENKYNEDIKQNLEKDFLSINNIINLISYLNNINDDVNYIKLLTLCLKNIILCKNEIIDIKTFRLLTNELLNIKNIYQNIYISSEYSYLNMLIKHYIKIMENFIPFFDISDYFKVKQIFIKYSLSNKYLKPLIILNNELNKVSIRNINLNFIHIILQFYLKLNFINEQFIGNLLHHYVNFIYQQMENIPNTTIISNVIKTNELLLSLCIKNKDIINLNFVIAQRYTNYMNEFKIDDSNMSNKFSNTEEAYNILEYNLSNSKDEISDQKNEPIIEYEKDNGKSYDNNIFNNVEKETEGDIHNNTNKYSINKEINDDIIEDQTIVGHNNKNNHSELIHIQNEDDNKNDAIVQNKKYELSLTHKLNIIYFLCKFHFYNNIIKSYYFQLINECLNSESLSFNDEEYCRLYEIYVHVILNFYFLSFDKNNKYINYILSNLPCYHWYKKEEEKLNLFTASKDYTDINTILRILNLNFLTPTLTEIYFIHFFNDLKKINSIEIPQNVFHLYQKYNLLIEDIQNKNVAILCVPEENALLDENQDYKILTNESHYIYENIRKTYTTSLLFLSEVTYIHKKKFQYYFYILHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSP3</accession>
    <name>V7PSP3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">YYC_00772</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="4"/>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSP3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000027">
        <property type="entry name" value="Cysteine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="15">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Cysteinyl-tRNA synthetase class Ia DALR" evidence="16">
        <location>
            <begin position="317"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETB62145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="495" mass="57810" checksum="42351DCB49BE8654" modified="2014-02-19" version="1">MVINITDIDDKIIKRSEEEKVNFTELARKWEYEFWEDMKSLNVLLPSSITRVSEYVNEIIKFIEKIIENKYAYVSSEGSVYFDIDAFKKNPNHFYARMEPMSVKDETKILEGEGDLGVISKNKKNSYDFALWKSSKPNEPSWDSPWGKGRPGWHIECSTMASNILGNVLDIHSGGIDLRFPHHDNELAQSEAFFDHSQWVNYFLHSGHLHIEGLKMSKSLKNFITIKSMLKKYTANQIRILFLLNKWDSFMNYSPNGEGMTQCIEIDKFFTNFFALINMKIKNFDLNNCDLYWNDTDNKLNNIFRQTKTNIHNFFLDNFNTPEALVAIQKLISEINIYLQNGKIQIGLLLELKQYINFIMTTLGLFYDEAQKTKSNNFDNLLHVLGSYRSNIRAILQKNAKLIRKISKGIKTDTSDTATLDNNNKYNEFIKEIKTNNEELLKECDILRDQHLLNMGILIDDRPNNEFVVKVLDANQLQQEKEKRECDLNKKKDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSQ2</accession>
    <name>V7PSQ2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSQ2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="267" mass="30122" checksum="D990E6117626A64B" modified="2014-02-19" version="1">MDAQNKPQIIEHINHSFDNTVYDVKWVDKKSSLISVGERLDKKGYISIYNLNKGKFTCISNSKTDNGIKTIIPFYSYSGAYTIACGAFDGSILLYDINNMSKEYYSIKKHTKLINKIDCKNSKNNNIIVTGSRDGSVKVFDIRTNNEALSLEPPKDSPYIPDCWCVSTGNNYIEENTFSGNYHENLNICAGYDNGDVKFFDLKMVSIEHEVNVNNGVCSVNYDRKDTKKNKLICSTLEGNIYIFNLDVYSEGYGYSHSKDQVVSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSQ5</accession>
    <name>V7PSQ5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_01509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSQ5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB61657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="54308" checksum="59217D0B2302B20A" modified="2014-02-19" version="1">MKTILKYAKKKNSDQNEITNEDDQTTINCISINDININDIEENVITRDNNNENKKKKDKKIEYYLFDVESYNSNNDTSLNSVIDLNSIKSHYLPENKKKNAKKKASNYIKKHVKKYKKKYKILPEHNLDQDTSYEESVKNEKKDYDTYELKEIKNDKTNIDFVPSQKKENLSKKNNSFIDVIKFVFLISCIFSLGSFSTTITKYIFFVKKFNYTQIVSFFEFLVMFLILKTFIFFAKIKSSTSLTRKQYIRYIVFISALLGLSAISGNSAYSYLEIPVISVIKSSSLVLIYFLSIKFGLKEFKCSLLVSILTILMGVIMSITTLKIDSLFGVFLLIIYVISSSFKWVFTDILLKSTSMKAHIILLHIYQISMLIIIIPTLLIDMPCIINDYNNNNLSIGQILSSLGFVSLGAVMSIFLILAEFSLISHTSSVTLSIIFIGREAIILIIGSVFLNACEYDESCEILFNYFSLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSR0</accession>
    <name>V7PSR0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_01509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSR0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB61662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="44552" checksum="1FBD03E95EF31A90" modified="2014-02-19" version="1">MKTILKYAKKKNSDQNEITNEDDQTTINCISINDININDIEENVITRDNNNENKKKKDKKIEYYLFDVESYNSNNDTSLNSVIDLNSIKSHYLPENKKKNAKKKASNYIKKHVKKYKKKYKILPEHNLDQDTSYEESVKNEKKDYDTYELKEIKNDKTNIDFVPSQKKENLSKKNNSFIDVIKFVFLISCIFSLGSFSTTITKYIFFVKKFNYTQIVSFFEFLVMFLILKTFIFFAKIKSSTSLTRKQYIRYIVFISALLGLSAISGNSAYSYLEIPVISVIKSSSLVLIYFLSIKFGLKEFKCSLLVSILTILMGVIMSITTLKIDSLFGVFLLIIYVISSSFKWVFTDILLKSTSMKAHIILLHIYQISMLIISKNKLYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSS9</accession>
    <name>V7PSS9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3'-5' RNA exonuclease USB1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_00354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSS9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB62646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="273" mass="32158" checksum="80CEEF414AB8CA0C" modified="2014-02-19" version="1">MCFIIFYSVKCNKNIKKKCEFCFGLLHKLLEKQLSINTNDNDLSNSQNKKKEKENEIKKHIFYQLHKLNDDQIRYKQTSQNNSMDMLHITIADSLKIKRHMIEPFIEKIRETLKTQKCFYLFFKNTVDLYKSQKNSKYFCAYSVKEEDQKIHLNSIMEKINSILTNFGLCDIFSTNRTCHMSLAYTNISLDALIQNNNLNINDNIWFDINKIINNNNDKAQNEANDSNEFYIYVNSISIRVGNQIYEIPFNTIGGYSYELYTDDSYNSSSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PST0</accession>
    <name>V7PST0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell cycle associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="1989"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2402" mass="287983" checksum="C2A61216E0C54804" modified="2014-02-19" version="1">MLTQVMHKCTYICTHLHMYTHLTYFSPFRNSLNIHDIYYIYDEETEISDLIIKRYKENHYLTIFNNMLIIINPNKNVKDFYKLLFKNKNKNNYIFKLFMNNIKEKSIEEKYENDNINLQESSESSDSSYRNEQKKTYDHINKNISYLNTKELINFEILKKRKEKYRKYISTIRKNLFINSNNEVTDTHSDNLKKFATLFNISLEIGKEKYTISNSDSINSDIDENYINYIEKKKKWDNIHINNTQNDSYRSNSVESKQISYEQLKNMHNNRKIVISECKNKLLFIHGEKYSNQYVVNNYILKHIIKDENNKELYYSYKNIMSILNLFFVNKCFNFIIYKCVNNKIIYFNIVPCFLSEENNNVTNICTKINEFYNQLIDSEKKTNSQKKVAKQMETKEKKKSNHNNETTHSPSDKESNGNGTSIDNDNNNNIKEKIIDLRKIINIPHIFFFLLKCILNNNNHRFFKDLKLHTLDIKKICRNYIDIPYIKLNSFDADKLFSSFLKIGFSEEDIININKIIFAILFINIYIRIRNCLILNEQKALNQLQIQLIQVQDYIKLRKLHINNNENMKGKNTQLNLNKFLNFNYKNYVNSEQSPHSEYGNNNISKNKNSEKKIKSNYFIVFVGHILEEYISYLLSIDLCNFLDILNDTIKLTNFCSAVYFRLKLKIIKQVNQYLNNRHSTDRNINHIWYIYSNSGVMYNSMDQNYNENNFSKNNNNEIEKYQHVCNENKLSSLSSLINNIYNEIIYSYYIKISAFNLDICTVQAIKNIRNKRKSYEDATQDSINKYKRIKNKLENRNLNNSYIYKCKKNVILYLLEKYTHKILAIIEEDMSHDNLNINNNILTKPRYFKLIYSFYLSIKKIMQHYSGIINKLKSTKKIYSKISESINERSDEHKEIDNEKSGGNDTRQKYYSENYIRKVVNKIITDINKMEELNNKKYKDNIITNAKKSNFSIVHYNNDNIRYKCNNMLLDNFKDLCSLNNTIDIIENTEMDFFKKLFLDKSIPLKFFKNNLMHNEIIFFLYIIKNCYERFYIYLINEREKNKTDNSIIFSKYIDKNKNLYPQFSIINENELSSSNNSIINNDNIQNRNNESISDKDSDLQDDLIVNKSYKKYQKKEKTDQVGKRMESYLSFISYKQINDFSELKKKLNKKHIESIVKNLHLKTIFKYQMQYLYYNISYMDFINKYLRFCVYINTDGSLAKLINWYEEKFEKTKENYENYLPDGSSLNAIDKRLNEGVSKKWKETKIKNIYNSTNNSQSSEEYIQNYYKLENIPNKDKKNLCKIIVHYLNLTKEDVYYYNNFVFIKKRYYFILEHIRNEFVRTISPSTKKNEDFWLTYKNQKMKNFYTNKVVKIQNYIRKFLNSSKMNKIEKKKNLLVSFLIFYSYIVKNRNKGETREDLELYKQKFMKEEKEIIRYAASVYIQSWYRKIIQQRKYKALKIETYKKKAMECIYNVIKTYIVQIKTIAHINDVIIPNRCALIIQTHFRKHVCFTDFRKKLLLKICFLSIKRKYLTYSNIITKVNYHHLAKNIYNRNNIQSLLKIPKAVIKIQSKYKAYIVRKQYKMLRDAIYFTQAYIHTCLESIKYNNIKNSVILIQRWWRSFCKLKKVFSNVQLNIYSNEYDKRKYFFLSKDNFPFYNYYTLKEQKAMKLLTYNILLKQWYFFYFKKFQKKNHIFNIVFNLKLYKNISYHYTLPWAYKINTILKIIYMKQMFQKCTNNNQNTIFNIPVFESIQIFIGRTHTILLIKQTTSNEQIPWNANKRNSKNYYHTFVYSIGSNEFGQLGYYNLFEKNFIYNINNTQNEFNSMNNDEENIDEENPLEFDDTNKYDSTLEENKTKKKNLENGDNIILKNRMDSTITNSSDITDKNYKKEKRFDNENSSKEYIPYNTEKNKKTKINSLSNKYKKNLQHLIFEYKDKYIIGTENFYKNQEDKSINDIVDYKIVEKENEKTGEMEKVVQFTKVISETNKIINICCGSEHTLALSENRNVYAWGNNAYGQCGHKYELNVIRYPKIIKYFKKNNIHIKNINCASYHSGYITETSDLYISGNFFFINLKYYNQNLYEPTFLISDCHNILCRDNFNIALKTDKNSLYLWGNNYKCILGINKEKLGNLDEISCYPLSIISKTIVVQKIVCSENFVCLITKYKTAEYSLYMWGEFTLIEKQTESDTSSIKSNTINIFNKYKIKPIQRNTDEQIKKKKIKNKKILIAKPSPVYNDVWDSLDAIDICCDLDEVLVLMSNLGLYGFSSVEMFENGNEKTQSNEPQFSFRFPNKKVDEKNEKSYNYEEPKIYENIKLLNPSLYMFKYFKPSYFNIKKINCSYNKNSLSIINATMGQYDIQLKKKKMDYITPSGDIAQFPKKIQEKMLEMEKRESNKWIKSTDDPYINHFLVNSSDSDSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT15</accession>
    <name>V7PT15_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U3 small nucleolar RNA-associated protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT15"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1158" mass="136347" checksum="DA08BBF6C32B3E0E" modified="2014-02-19" version="1">MNNWGSDRHFNARPRNVSLSLTDFKFYKNEKRKIVNMEVSPCKSYLNICDSFGTIYIYQFYNNTFIFLLKGELSNDLGSICSSIWVTKKNKKIKYLYLFNKLEDYLLFIAAISGCIYIFDLELKTTIHTINTNGSISSCKLNNSLQTIGITNLNGYFNIYNLYKNEDNIIYNCFDQFYEDTKENTTSYNKHDEMNPENYENIENTENIENIENNENIKIKISNVASYILDNVEKDESNIDTIVQNSLGNSLGNSLGNSLGNSNNFTPEFFSKNKKKEEYEEDIFNIYVKDQFKCGEKLTCCYFVDKLKSRKFLLRMLNSKNYHKRRRLMHLSASGKNHPDSEAEVGEAEAEADESDVGEAEAGDDDGDGALTQNRKRKKSKKRDIEKEIRSIEKTYSNYNHYALIGSEESKIYKYNIDSKICEGEYVSINNKSIIWDVMYIYKTDEVVAIDNCGDLIIFDYKSYLVKCYFKNHTFKAISLTKNVNEDYIFTAGIDRYVIKYELRYNKNGTQNCNYANSDGEYSDGGDSGDGGDGGDGVDHSNFKESKNFEQNIMIQKNKFYINKIKKIKKLNKKWVFSHKHSMHLSDIKKIIYLENDIVLTISDDLTYCIYDTNKNIKKYFFIKYYYENNNILFSPKFKMIFCVYSNQITIHYNIHTTHQLSDTSIENEERGSGDKRSDDDEERGSDDDEERGSDDKRSDENRISVDNLSQLNECNYNPIANIVYDSNERISEYGINKSFTKLGCITNKKFCVYNFDMNKLELYNYDVSALNFYKIYSFTFLNENEIVVSLSRYFAETNNNNDNNDNNNNNSSSNNNNLDANLMYLKKYINYYLCIYNVKKKKIIEEVKVDRIFYNFKNYQNKLIICSDYMKNIYLFFKNSKKYLNNFIMICDYNINIQNINKYCIIFFMIEQFLFIFSNNNRIYVYIINFQDKNIYFFKCIKINRCIFNQISKIQFLNLDRITKESEHIQKNSDHNYDIQNIMNLKYRYCLIIKSYDKLIFMGLNLFDNIYVNIEDECLKKQIKKNTNYCSQYYLSSLNFKYNYLNYKQIYFQDNNLFHTIFNKINTSEQNENNNTSLSNNEKSNVTDLNNPCETVQNYDHDVFKLSFRFLSCIIKRGVIDIHSVYTSENRITILACGSSYLSNSLLDAADTKKYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT17</accession>
    <name>V7PT17_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="675"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1810" mass="214376" checksum="0C3B362645C0FCFE" modified="2014-02-19" version="1">MEEMDTQNKGVENNENLNNCSKVIDENVINTLSLNCTEYHQDVLNYINYFFLENKNNIDIFFQVKDSLKCSNLSLTQLLKNINLLSHIIYFQNLNEQNLLTSNDIEHIQNILYKNENNYSTNYTIIYNSIIFLTEIIKLSSHVGTKIFAYYQIYRSYAIIQKILFKDFLIHNLNIKNNEHFYVLKKNEAIFIDNHIILNIINMLNSENKLLKNIGLYLCHIFINIISQCNYIINYILLIIFHQINYDEYILAFSLLVKLVPYLSHDVLYSVIKKIYNSILRRRGRIDKGGQSTKVNKLGEVNKLGEVNKAAEINKAAEVNKPAEVNRYNVGSVRRLANDIFSYTACIFLGHISAILNDVNKYVSYFLFKKFWILINEIMSLDYIRDIEKNVINLIDIFFYSTTILSINNIYLFNIQMIILKLLLNISHTHLIKKRKILFFTFRSILFLLKKNRIIPYISNKYFLYQNKQFFKTNYFYYIYFTFILTIKNNEIIRWFNLVDLDDEITKFIFVQIIYEISTIQNCLYFPKIEKNIPKKVEKKVPKIIEKKVQNHNFVANCSSNVHDIYFDIFVNRFVSLLKNSHFEKTEKNEKTEKNGEKEAEKEAEKEAEKGVGKNGQFNFTININGEDKDNGNNNLKNEAEKNGTNLDVENKIDSFFENLVKLAKENEKKKKLVVKELDINLVIKKDEREKEREKEREKERENTNFLFNLSMNPSNCDSQIEINNNAKFISPCNDVKNEEFTNYKIQTNEEISSIDSSISKNSFISEISNNIHMTSSSEISNNMHMTSSSEINNITSNIFINNKNCETVENYFIYYCLYLLKTNKIKLGNLFHKDTINRHHIFGNEYLKFKQIIKNRKIENTIESHNLEEKLSDTSYPNKEQINNLTIKKIMFIKILFFLYEHSKSILLKLHILKCLAVLSRYIVFKNDAKNMVRIFNNFFLFLNIIHSSGPNNNPIRNLVSDEDANHSTSIHTQHLKKKNVKNVKNVKNGKNIKNKNKSDEMYDHLDNGFIYTSGTSNLYNDSISLDKPNLNGNNFEQILNELKNDTNISIRAEKFNFYDDYNDEIPKSLIYTFLIDIIYKLKNCKNNPILKLFFHNFFSNKFVQAFDIFFILKKEHIIEILKDPFFYLIEQRETQSEDIDSNNILNEKKQNNCIYFIKKKNFYKTFHLFQFEKNNFRNVKLLFYFSFFNFHKDKYIIHEMRKKTIIFLTILNNIFYFDNTHTQKLCTSQVNSVNSESKNYKTQNDVNTKNDVNAKNDVNAKNSLRNLKSFGTSISDNNSVNDIEINVNDKFSCENDNYMNESGSGITTWGSSTSYSSIPYSEIYSSYSYSDEKSENYDDIYSISSISNKSLKNRLIQNYKNLENVEKLNSENYIKINNLKNNQNNNITHCSHFYLYKIGIFCIRAGYFKYGYKIFEKLYLLVNNRDIKLWFKALENYSKFYYIKRKGEHDNKLTYLLRPIKFLENSEQFIKSIYKFKDNFFHLAIFLKIQLNIYKAIDNLLTLVSDIKDEINFTLNYFFYNIDKLISSLKDILITILIISNIKHIFSILSKKILGIYIVLVKSLFLLCIFLKHKIVPYLFLSSSFLINTFINRELKQNKEYDEKGENEEKEDKKNKMICKNCDEESDTSSIGSIDDMDNYEQDRSNMVIYSIQNFIRFYIHKKKEKNIRKNIFSKELKNIEGKPFNDVFDYIMTMWDLRAFEFFFYEHIQNLREIYDNLFKDGIINKNKIITFIKIYLTIIYKINYPTPPIFLSSQLIPFVESSTYIYRSNTDKKPHEIESMKCIGQLVGSKVEKEKNKFILFIITLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT22</accession>
    <name>V7PT22_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_00882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="158"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="627"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="1244"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="1411"/>
            <end position="1532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB62275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1631" mass="187831" checksum="2C117A613C693ECF" modified="2014-02-19" version="1">MSIGKKTQYNIKVDIHEVKDLSFRESTNEKEIIPNPYIEIKVNDETKSTAKKNQAVNVVYNTSFNFSMDLTDYDFQRTSVEVCVLHKYTIQSALIGKCSFSLNYVYSKVQHWIYRIWVKLRNPDLPLDDVGYLLISVGVYGPGDSIPIINDSIKTNMNEHEIYANNKGIDMHITHYDLCINIFRGQDIEFINNANSLFQNNLEPYVRVIHNGFEEKTKIIRNDPNPVWNLSVHLPTCTPCYDKNIIIELINGETNGVVIFSILLDFFEILKREIVPRWFNIYYNPQNYIFPRSSIYSQNVNQNSTNPHAFGNNQNSSNNQSVAGIGNTINNVSTFGNYLFSGTTAEKLFKNAAQGININDILGITKVQNIFTNDSLKEFYLYGGRIFLGVNITKTHAPGPICIKSAKIEHDPPNKEYIFCADIYEILGVEGNNKQVEYETNNLNNINDGNVLNDKQSFNSNGDSIICVCGLGPHKLKTPPLLPNEVGSYVLNESAGRINEFRIFLPQNNNEQIYDIFLYIYVKSNISVTDWITNRRNIYNSILNTEYEDGDINKIQKINKMSSINKISDDMVNTNSEILNNYRLKSFVRIPFKYLLLNENKPKWFSMKNVETDAHDYNISFFANLIPCNLYKKRPKRLEYKLSRYFFRALIYEGLHFPAKGYNAFPDPYIKIEIAGQTIKTSTILHTLNPNYYEAYEVEVILPTNLNLAPDISIEAFSVNKSFLYNDDILLGSCTYPIMKVPMEWKRSPIWINLKSSQYKKCKAKLLVAFELVPYEKVINDDQYPFYDDIRPSTLPGHVSLFLVGIRMFKPLKDPSVTVCFGRDIDDTSQFLWYETTNKVISGKEGNWNFLKYFSLDVALPKRMQHHSFLEVRIEDKVSNSGFSGGPSNGYNSINAINNDNLVGTAYITLNPLLPWLYEYEQRECIELFKLHLLEEVLIEDAEKARKTYNSALIYKKSSIFSKKMSNDIFEIQGTDEERDEYGNSNVFHALSLNMLEENPFLEYGDEDAEEQDEGENGFKNVMHKIKDDINKEDEMETKNSVNELENKINSNDILSPNGIRTQNGFEKIQDGNHLKKDIKKKKKNRKNINNEYVPYNDPDFANVRIEDPLEHVCFTQKTGNIDNDVDVSGYLNNNKSLSNINENNMNKQYASANTLDNAENCGKGIYGFSEDMLNFQLSLAYDDDHDELQREEMLYEYEVDMDINDLPYLRATIFRCTDSGIPEAVGYLKYICNVYDEKTMHKKKEMVKACDNLVREYKLTRNLVVRAYIIQARGLNPPSGATDITTYIWIKNSDEITNIPGGLSHNIKDTGHIKRQGYKPEFNRCYQLLCSFPDESIIQVCVMNQGSISDEIIGYTYIDMEDRYFNKKIKQLMLDDIMPIELRSLKLENSTISHGSLRCWFEIFTEEFAQLNPVKILCSNEPDDYQLRLVVWKVSNVAMDNNSTVSLFVRCIYADDDSEDIRDTDIHYNSKNGKGIFNWRFVYNVKIPTNSTTIKVQIHNYALLSSNEPIGESSLDLSAHFYRARKKKGFYHIPRFSISCKHPAHKNKIRGNIEVEACILPKNEADVDPVGNGRDEPNKDPFLPAITENRTYVDWVTINEKLGDATASIMQGLKWTGIFIMFVYICVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT26</accession>
    <name>V7PT26_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT26"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="586" mass="69468" checksum="235F959F7A99C799" modified="2014-02-19" version="1">MKMRNGKSEDNTLSIEDDMIKSDGNSEKNENNIFINKMKKILVSQNEEIILLNEELKKKNKEIFYLNEENITKDEKLIELKKEIEENYLHLKECKNMQSVMQINANNKIYSAENYLSATNKKLLENNIDIKEKKLNIEKQKKVIKELYNQLNKKDDQIMELRRIIESVELNNNRDIIKYKENNIDLINRLRLNASLMNNQKIEIENMHINYKQLEEELRNKDNELKKLHNNILSKDDENNKIIQDMNRLKFDMEIKNIDILNIKKKMKGIKKECSINLKKQKERFTDIINELYKEKDQIIKKHSEDMSKLVSHYNEVVCINDNIKNEINTLKDEVLKKACEIEKLQDRLIDYEAKLLVYENNNEVKMLKKNENHLSMLLNKHIRRNEELVNTNLLLQKSTLENNNLEEKILELKGTIYRKDHEIKSLHEQNRKKKNSSSNSNADKHIMEIYSEINNDNNIIKNNNNISDININNSYSDEVCSSYVSKKISEKNNNRSIIIQNENINSQLNDTSNSIEDDPIYATLCELLNCNKENNSLFKINKICDKTYMINDKKVFISFINGELYAEHDGYPVKLQDYITQNLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT29</accession>
    <name>V7PT29_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT29"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="309" mass="37543" checksum="2095C8288DE0FDE3" modified="2014-02-19" version="1">MHHTYMHTYMDTYMHTYMTHGYILFCHILEEISMKLGKIHLCKSYLETYIFEKNPYNMNFMYLKDDVSESKNRVLNSVLLSSFCNMIWSNNIYKHEYLMSKELLNKYFKAIQKNPDKNNYCIVPIYDLNKIKMILNDHEKNIKMLKKRKLIIRKNNENLLFILNIIKNNFAEIKIKAQRIIQRLLFRLDILDKLFILKNNSSFFSNKYEFSKFKLIEILDLFNSFSIDTQLQKINQNIEEFVREKRHVQNFLYTDKEFTTNLKNTIEKNEQHITELKSTTSEICQNVDENREYLYSLSAFEREDNYEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT30</accession>
    <name>V7PT30_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT30"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="924" mass="104938" checksum="1CB5AE803363AD30" modified="2014-02-19" version="1">MKKKKKSVDMHIWKDALNDFEVSRKNKYSLTQDTIHGRLRPEPEIVEHVLEELEDKIRHYFNLYKNEKEKRTNSESNNYYLQKEIYNAYEALDKNNMYTKKLEDKLENIKENQSSLIDTVRRIDLLYIQLDTLVQSFAGVCTQIASDTAESSDNINKKKKTMKMLLDYIYPCRTLDPRINSLYGMLYYQSIGLLKDGKFISPPIPPIPPLVPSEDLNGWLPPSDYVPNHQIEYTNNGDLVKSMSSGENKNSFSDLIKMYKQGNNNDSYEEFFSKYIKEEQDKLENNENVHNVLKISNDGNNNMSSDQNGYLISQDLQSFEININNLEIKYLNGNPKIICVVRYDSESAISAIQNTQRVTRPKDRIDIDSNVDYLTFNINSRILLDKLPEKKTGDIPSFMIDIHDVSGKVLVGTSRCSFISEKTLINNAPWDIYSRLNKSKPEIIGKIYVSVYPKPNNSILPAEVFKNLKRNNKNTNIMHKLNPSKATQILTNTHNPNMVNTDTKIEYKTVKVFQKNAVLSKAIYEKDQEPIPQLEKIGPNNNKTTTLGKRGQKVTFKPYVSKSDKNVESEEKKPAEEAKGNEDKSKVTTESSDTDNAKSENEQTTSVMSRIRQLTMKFEAAKNKTEGNQNNTPLKLPFRVKGKENNDEKVLEKNKSVEKNKSVEKNKSVEKNKFAEKGKTAEKGNIVEKGKTVEKGKIVEKGKTVEKKQFPVMKDGVMKVKLVSLGKTNVLKDDKTKEEMKSDENDEDKKTDEDKEDKKMEEEKTPIDVKKISSVNKLKPALKMKIGPNKDNLKKILASKQINKEGIEKASQIGQNKISEEKEEAKAVEKGEAKVVEKIGGKVAEKIGGKAAEKIGAKAAEKIGVKTAEKETIKEKMLSMFKAKKSKAEIPPKEIPLSVKLGDAAPILKKPIMKPPPPLNESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT37</accession>
    <name>V7PT37_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT37"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008536">
        <property type="entry name" value="DUF818"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05677">
        <property type="entry name" value="DUF818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21221" checksum="5AEDA360E6C2301D" modified="2014-02-19" version="1">MLYDYFYEVSEIWNVNILLYDYPGYGESTGVANEENMYKSGYAVYDYMVNTLNIKPETIILYGRSIGSCAAVDIAINRKVKGVILQSAILSLFNICFKTRYILPFDSLCNIKKIDMIPCYVFFIHGMNDKIVPFYHGLALYEKCKMKVCPYWVANGKHNDVELIDNQKFNENIKLFLNFLNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT43</accession>
    <name>V7PT43_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT43"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="276" mass="32851" checksum="EBB08D3B82A94817" modified="2014-02-19" version="1">MLGKRKVDNTQAQKKKKKWVEELDSDSEDIDLDYLNNLDENDKIQLEEVSDKEDELLDQLEKEENKENKDGSQNMEDTINDGNDNKNKKRRYDWMSSDDEDIPSDDEEEDIEENDNIEDSDNNIENQKYKNGKEENNNDIKNNYSNPIDVHKKEINKIGDINDIENSTNEIIENINKYSIDQIDIKFEEIEHIVTYVYFHNIHFDCMTENLVTFLENHTKNKIIQINSDKSTNHAIIYKYDEKNDEKVVINKFSHYGKLFVHVKNYQVNYKPIYCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT53</accession>
    <name>V7PT53_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI transamidase subunit PIG-U</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_00477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT53"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB62799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="56345" checksum="4478249B2CB990C7" modified="2014-02-19" version="1">MNISMKIQNKKNGLFASLVICVIIRVVVFYVLNILEGSNYEYIEKIININSIIKEENIPNLEKSKLNNNEYKTWEHNRINYLNGNLEQYFQMDKRYNKNIKENIFKSDSMYYSFNSDIYNMKYIYDSYILRKRYKDIYSFLVLRINPIFLSFLHFIIFNEKKNIMNKVRIKTSEKKINRQSNVIDIFPYHEFRYFMLICLTDIFIAIFLFLINEHIKKKKDFFNYIYEQTSQNGWKLINPVLLINIYLNNPLTILANVFLSLDNFKLLIITMSFYLTILRISTNSNKIILFINFFCIIVLNSILIYITSFHFILIIIGINNFIIFIKDNIIISHIKKQIEFQKLFFMLFKNFIILLFTCIFYGLLIIVSYYMNGKSISFLNNTLINEYKIFYLIPNLGNYWYIFSTMFKNYYYSFLFLFHFHIFLYPIPLFFRLSKTPLIYLKIMIAIALVFHPNIVVNDIIYVLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUT4</accession>
    <name>V7PUT4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_00141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUT4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052298">
        <property type="entry name" value="ZMYND10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244:SF7">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="300"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB63326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="340" mass="40485" checksum="D8B6091552D3E179" modified="2014-02-19" version="1">MAVLNIFELILLSDHIYEQIDTYIINLFAYIYSNLVSFLKTSSDEYFVKPITELPISEILKEENDKTHNIDRLKIYINVINTLRNIIDRIHLLNNTIVNKIVDYDILLILIPLIEKKPWKHDNYIFEQNEWIKNEDNAMATVEKQLWIILYTLILNSICQEKYEMTNYRRNNILKLRKYMNENLYEQLPPMKTLHTFIEHLYISKSVFPENKNSYLIIDVVPEIFDEIKNDILKNKKQVLSMLNNITISKEVLGSISEVYLSVYEFDHQIKKSKKKTKEINPIDTNHGEKEKPIDNQYTCNSCKEMAELQCSQCKQAYYCSKECQMKDWFSHREVCSSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUT6</accession>
    <name>V7PUT6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_00173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUT6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="92"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB63379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="394" mass="47374" checksum="D1BD14EA82D23D3E" modified="2014-02-19" version="1">MPQYILKAPWYLNQTQPGLKHQRYREADKVKIEEERNRKIYVKNIKNKQDFCKNCGSAAHTEKYCLERTRKKKKNFMNKENDEDYLCVTQDLGYDGNRDRWVGYDPNNFDHIYREYEKIVDEQKKRKAEKLKKKYEKQSIKKKKEENEENEDEEEGGDAEDSELSSDSEKDNDLNDNKQNNKKNNKNEKNKTIARNLRIREDTAKYLYNLNLNSAFYDPKSRSMREDPLANIKNNLENSNYYKGENYYNNTGDAIESKKLEIFAWESYKRGENVHFNAQPTQLELMYKEFLEKKNKLIKKKQEDILKTYKCENITKEMNNQQELIHSEVYTEYKPVDQIDSKKNNKIKILSKYEEDIYISDHTSIFGSYYDRETKKWGYKCCKCTDKFQHCVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUT7</accession>
    <name>V7PUT7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUT7"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="8">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB63331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="328" mass="38106" checksum="A50F5919D518899E" modified="2014-02-19" version="1">MRQAGRYLPEYRELKKNYNFFDMCYNPELSSNITIMPYKRFLCDMVVIFSDILIIFIAMGIDIQFIENVGPIFNKKINNLDDFKTLNLNLKEIINNLHFVYDSINLTKKKINNSVPLLGFCGSPFTLFTYLTKDNTSKLSPYENSLKLIYENSEDTHQILNTLCNICISHVLNQIDSGANLIQIFDSNAEIVDKNIFKKFSLNYINKIIQAIKKYRPNIYVILFIKDNFHEDIKNLDIDVLSITHKQLINNGSNYYYNLFQNKIILQGALDPHILLLDNKKNVQKYTSEMIQQISHKNKYIASLGHGILPNSKIENVYAFIQAVKSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUT8</accession>
    <name>V7PUT8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUT8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="296" mass="35392" checksum="05782AF6093C6FA2" modified="2014-02-19" version="1">MPEKMEKNGKNEKSEQNGKNEKSEKNGKNEKSEQNGKNEQNEKSEQNHNRVCNLNKLIYHNLKNKILDIINDSDILCFQIKTFSELENCINRNVVKFSNPNYIDTNCLDIFPNNTKDEIDRNKKLDIKSDLYNHYILNLQIKNIYYDLIEKNKIFIDHIQLVKDEKEPCLLFLKLNTNNYEIKSDYIIIQDIEYLKNIINDENIFYTIYKILDTYTFFFLCNEKCNVKDKFMYSLFKAKIIQFLKKNNIVIFLSIEISKPKHVLDFINSDILKTEKKKKHTFKNNYIHNQKRAEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUU1</accession>
    <name>V7PUU1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUU1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="7">
        <location>
            <begin position="439"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB63336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="65204" checksum="BF66F3D27CB55F26" modified="2014-02-19" version="1">MKFAEKLKHLKVKSWDNKYVNYKFLKKIIKKKINPEIKALYDRIDKNDEQILEVCKLVNLDNTLLNQKDKKKKNEIENEEIDYTYLFFYVLQNYINMVKEHYESEYNYLYEKIDEIVFFLESDRVNLKDMESLKNKCLNIYNLFDILTNYLNINVLSVYKILKKKTKKERLSTSLDLYQKYCNNLHQISQEEHFNEKIKSTFLLIQKKIGDNCEKIDFLNFKIYLKSKIENLGQYRGTIFILCGILITLIINTIILLYLNINEININRILSILPIYRLIYVLNFFFLFIFGSFLFMQLYGVNFTYILDLNKKIVNEYYYLINYVIFLLFLTTVSLLIFLLDVLFNLNIFSNIILHVVILCILLVCTTIFPFNFYKYKENNFLFSSLSRVLMSGVFLVNSVNLLDNIMGDILTSLSKTFSDVQYIICFFLNGMDTTAPAKCPIIESYVNPIFVGLPFYLRFCQCLIRYNNERQTIHIYNMLKYVSGICIVICTSFNWGYLGLDIYTSKIILICAYVIGSTYMYIWDVYCDWGLLKEYNYLLRYRIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUU5</accession>
    <name>V7PUU5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">YYC_00538</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUU5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="360"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETB62910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="842" mass="99152" checksum="799BA79E8EBAA3E5" modified="2014-02-19" version="1">MYRCVHRGYSLFSQIFICSRTQSQLNQYFSELKKIEKKLSKENLPINMIIIGSRKHLCINEKIMKKCPNVNELNEACRSSKCKYKEGFTEMVLEKKKKKKKIFYESSSDSNSSKEENDEINNYILIKKLINTKNIDMNKIKEICRHDKIEICPYYMCKENIQNADIILLPYICILNEQIRNNLKINIKNNIIIFDESQNIIENINNANSIGISKSQIIFTKLVLKKYIQKYENSLNNNNVIMIKQIIIYCDLLLKYFTSINESVSNITRFMLLSKLDALNLNNISAFLNNSLFCRKFKIFAEVNINEYFKKSNKERPSIISAYVNTSSIYLLCEFTNKLIRSNKYDSIYINKNDDNGIYNNSDLEDDNQYNNKTETLNTNNNSNTGGSNSSCSSKRPGCSTDNNVEAEKKRKLQNNTNVIGTKNKNEPNNSNDDFSDLSEYLKYILENIKDMILKEKIEIISVSSCNNFQNITKDCNNIILIGGTLQPIEEFLLLFLSEKKNKIKLYFSDYIFKKSNIFVRIMPTNLLTFNSIDNTYKNRFDRSHLLNIALQIYILTLYVNYGNIVFFSSYTFLNEFMNFLYNEGKYILEKMKKKKFLFFEKKNDNNVLKNYMTNIINIKKQDNQMRIKNGCILFCVMNAKLSEGINFHDDFCRNILIVGIPFFKHEKNNTSTSNINKNNLVLNYYKEYSKDRSKKNDPNTHDISNSIPILSDWQISQMCKTYELKCAMKIVNQCIGRSLRHINDFSSFFFLDQRFNNPEIYDCFPTFVKTHLNDIKNLGYTNNEIFQKEKQNFHEIYDDIKNHYKHIITNQDPIKDSQNYLKNFVTDLVHLKEFHKKMNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUU8</accession>
    <name>V7PUU8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUU8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="458" mass="53815" checksum="1CF95F0710B98E73" modified="2014-02-19" version="1">MTTLNLISRYKNSRLYEIVQEKLTNISDLPNDINKREIFIDRNGNRFEYILDFLRDGVLICENDITVLTRILIEAIYFKLFSLMKIIKKKINLLYSNMNNNVNKNIFKRIISTIEKNRKEETNKLVKLSGIISNYNELKYFNLKKKKKKSYITILNNSNIINEINQVNKDIEQVFARPDKNDSTNLLSANFQKNESTNKLNLQSVTNEKERKKTNAYKESYYDTNINSEKNMNSQEKNSNIYKKSESPNFEISNKIEREVSKDMLNSNLKNDVDKMDSHLSDTNSLEKNEKDIHANSEYYNAKTIGHKYVSFSGENDIIFYTNSETLSDEEQFGNIKNSKDEKEANSNSKNISRLRNINVINNKVSELNYNNYIGNNDYIGYRDFENEHNNFPNYINSVCNKKSTYNYNNYEYNNMKNNVRNPIMVYSEIDDVEETSNYPIMPNINLGEQIFSTTVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUV1</accession>
    <name>V7PUV1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2537"/>
            <end position="2562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3261"/>
            <end position="3302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3460"/>
            <end position="3502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3047"/>
            <end position="3074"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3649"/>
            <end position="3677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3261"/>
            <end position="3278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3279"/>
            <end position="3290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3291"/>
            <end position="3302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="3471"/>
            <end position="3496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="4139" mass="498160" checksum="A2DEB8FF443A71D0" modified="2014-02-19" version="1">[encoded data, 4139 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUV9</accession>
    <name>V7PUV9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_00994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUV9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03428">
        <property type="entry name" value="NUDIX_Ap4A_Nudt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01405">
        <property type="entry name" value="TETRPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB62417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="157" mass="18010" checksum="9E8D3BA3CDEF23B6" modified="2014-02-19" version="1">MSGDIIRAYGILLCRVLGNIGINTTNNKIKNIEFLFLKASYGNNHWTPPKGLVENNEEGLNTAIRETFEETGLKKDKYKLLNFEKTLKYLVNGKPKETTYYLAILLNKDENIILSDEHTDYSWIKSGQSNEYFLSPSLHDLMINAEEYLINNSSLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUW4</accession>
    <name>V7PUW4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1385"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1425"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1529" mass="183894" checksum="5E7610446C1C5124" modified="2014-02-19" version="1">MIEKMIEYTLNISKEIKKKKEKKQYDNIVSSALDYYKNVNCSEYKEKHNGSNISCHTSIESVDPKKGENNKSDKKSENNKSDKKGENNKSDKKSENNKSDKNNEQDESQDGGIFLIEKDLCLRNDMLKENILTKLKININEYLYNVKDKIYNEILFAVDKKKLLNKYIYELQCNNFEVLKNIFFLLNNEYNDYTFNEIFHTLLLCFNKKDEQNILIIIYIFITLLNQNNINKSYTHILDALINILNIDQCPLPLYQKDDNTRLFDHKPMVIKNQFISEYCRYFLFLFFFYLMRLISNYQMSIHFDKIIQVCLVGLFDNCYEINLLIMNFIEEIINKIEECYINYHYIISTSLLKCLCNKNSKIKIKCMHTLVKIIKNNNNNTQNYKIIEMLIGYKDPNIVPIKCFYDNNYVNINYLCLLYNDKSIKVKYHFYSFIFIILYEFIDYNDFSTFLLPYLFSACFDNYKIFRFLSFIYIQVLLKRKQFGNISTDSASYNNNFQKNMNEEEIYDFFPEWSYKTPFTLPLPLTEYYFPQTYNNPFIIKKDYYKINLHIYDSNNNIKETTNNFYFDGNETYPVCEERDNNKKIKYDNFEIEKCVTNKINDYDEYQHYEKTINKFINSHPYISNILKENKIKDIDITSNKMNKEAKELSFTLLNTYFKHLYKKEDDETNKSQFLESSKIILLIFYFIEDNVTEHIPQFFSYLFNSFDKKIDQQQLNIYINSLYLIGSYVNPSNYYLFIENYLNNTTENNYKHITLICLYILYFTFLGAIETYNNIKKRGLSQSDIHPSFIMIITKVTNLFFLIITRDEYPEKYILILQIIYLLFKNEEVYTKIEEKTMTELIILLYIIFKKTTNTRINLPKEKDHMCIYKNFYISIDIFDLHFYLTRLRSFKKFEDINFDKESMNIQLSSETIYQVFKLFDKNINHQKIILDMLSDDILYNPYYVYYLIKYIIKKQNFFYDSNFSLFLCNIIIKILNINQNEQNIIKILLYNEKLELNDIHQETMKKNKKKVRHVFLEYLSTIFLLFIFKNINIYESFDNIIDTCKIIYYLLSEIKNPYSFLYFVKQTCLVHKLLDILECKQVKSLYFCKYIINNIYLEYGKYINNDGDCRYLDNINIKKKIEIKNRVNYEVNILYYFISCCIYLIYYKSLCCISIISNYCTEKNNEIKLNNFFNNIFQNTHKRLLNVLKIGEKNNNTFLNTYKHNINEILKNKNFMELFLLRNNVLKENEYNNLILSIHIYFRHTYDFLQNINTFILNPVIINYFYGVSKEHIYAENENENENKNKDENEDENEDENENENENKNEKLNDNAKDTIIESTHKTNLINTIESYYISDNINDIALIQYDTNNFCTYLNNHDIAFILLRHDIYNIPFRILENKSIIILLYSYILFFSDNFFIPNLTKNTNTPVLSNLNLGLVDDFFLNSSNMNTTYVMGIFNVLILIYLENENTLKDSLKKKKRFTYFEKLNNLDKTTFSNILNNIISSYENQDTEQKSLRNCINFLLNNLSSPYLGNIVILYFTSTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUW9</accession>
    <name>V7PUW9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1307" mass="154199" checksum="A8F7C90BD24BB892" modified="2014-02-19" version="1">MNKNKKKEKLKRKKKHTNSNLNLCKEINDNFTKLTDKLPNNKKEICNNNTNELGTNNNDSSKKIIISSASNSHTPENVQCVNKEGEKKKGGEKKGDIVQNGDHADKHVDEQNGDHADKHVDEQNGQNNFEIKSDKVTDKGKINQHDDISPPVLKKIENKKTESKENSKVSKDEIYNLVNLNNMEEIEKNINYIFPSINFDNNSNSNKLECIENVKNDDKKFEDEINKEIKKFQKDIKDVYFYHNNLKKGMKKNKCVNYENNMNHLNSTSDINLKNIILENEFVNFSEILIKGNNFLNLKKKIIKKKKKRKKKKKKKKKKKKNKTKLRTQNYKLIKELCLSYDAYTKETRQKQRKNEKKVRKYYIFEYSCGNTKIQSITGYIICYKSYEFYKNDINVLKIKPKEGNIFGKEGNIFGKDGNIFGKDGNIFGKDGNIFGKDGNIFGKDGNIFGKDKNIFGKDKNEKNISVLLCVNVSNCISPSGFLELLYPCDNFIFFLKVLNKKNSEEYMIYFLTFNIYTKKILNKAKKISFFNMKKKKKLKIYIVKGITMNVTSCITRNTNSDSYIKTNKFYNIDLEKKTMCANDDNDNDNDDNIENLQLISNTNLISPFYLISQNKFQLSCAVCLEPLYSVNLNKIISHIFNFSFKKKYSSKNKYNKEENKLQTYPSKYYYKNLNLLNNYNMNKYAYHLSVTNLINNLQNKYNNEMKKEREKNDKNRSKIFNNIPINILCSHIFHSSCLKKCCFTSCPICRYKQYNYEIANCDICKKNYNSKICLSCGFIGCSFNYDKIVKIKKKKIKEKKYLLKKKKNIIKKISYIFRKLINSFMPIFNTIILSLYYKSKIKCVYKIRTKQIYIPKKKKKKYISTNYNHQTNYITYYSDNHNKNKKIINYKYPNPQNNNDTQNEKTTNNNLSLFSNNDNIYINDLKKFYKYIYIGKSANKKKNVSYYFSQNINKCIIKKDAKKKKNDNKCKLQNKFGSTNAQENNETELKKGMRNEMGKEMRNEMGKEMRNEMRNEMGKEMRKEMRKEVGKEMGNEMRKEVVNEMANEMRKEVVNEMANEVANEVANEVANEMRNSATNVVVEKYTKCSLKKKKKKIKDHAKIHFYKTQHNYFFDVRKNSIYDYSSDIYIKKLINLKIQNKKFKNIYNTGNIYTNGNNSNPNKEIINKKNIILYIYDFNQLLNALLESQRNSFLSCIHDLKINYENINMDNLNDINKCVKEIYILQEKNNNLKNEIKKKINILIDKIKTNNNLSRELKNVETINAKLSADQRKQIYNYDLKNEQKKNIIKEKQQIIKELNKQVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUX5</accession>
    <name>V7PUX5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUX5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB63419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="137" mass="16349" checksum="38A53FF0CE1003E5" modified="2014-02-19" version="1">MKYTAFKNSLRFASKFCQNNNYKLYMNSVPQFSTYAYGKYLKTNPLTNRLDDLLKKNSNLISIISLNGLDDLITQSSKIESVSIADWLLNLVEEYQCMIKLHQYEIIIHICIYLYIYYIFIYFMYISPLIYTTFYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PV51</accession>
    <name>V7PV51_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PV51"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="316" mass="36586" checksum="48B14F81381BCAE3" modified="2014-02-19" version="1">MKNGCEYFISDVKEKEELIKKLAHFTYLENLRDKGVGIREISNNILNLLRDNKYLRNERIEAAKYANLCTNIESKVVEKKSFFLNKKKKKEKNQDENNKRTYFNSGNNNKYGPQKESLDQIKYERYENDDDYYANRHIESSQYRNRNYNKNSINYSQKSSINDNTENSTYSSSDSSSSSESSSENSSDNELPNYKSRRNISKKKDKKTNNFYSKRSKDMKSSSRSKSQSISSISHSKQSDNNSSPEDSSTSSDSTSKPRSTSSSSSSSSSSSSNNNSSKKYSNSDNSSYYSRRRHRQIDKGDKSRSWKREVSDRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PV57</accession>
    <name>V7PV57_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_01069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PV57"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000002">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000002">
        <property type="entry name" value="Beta-adaptin-like protein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="626"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB62507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="907" mass="104474" checksum="B2AF5B33374AD231" modified="2014-02-19" version="1">MSDLRYFQTTKKGEIHELKEELHSSHKEKKKEAIKKIIAAMTVGKDVSMLFSDVVNCMQTSNIELKKLVYLYVINYAKVQPELAILAVNTFRKDSSDPNPLIRALAIRTMGCIRLEEITEYLIEPLRRCLKDEDPYVRKTAVICIAKLYDISPKLVEEEGFIDTLLNILDDNNAMVVANAIISLTDICENSNKNILKDIINKDENNVNKLLNAINECVEWGQVFILDALVLYEPKNSKDAERVLERILPRLSHANSAVVLSSIKVILSLLDKINDKEFVKNVHKKLSPSLVTLLSSEPEIQYIALRNINLITQKFPHMLSDKINMFFCKYNEPAYVKMEKLDIIIRLVTDKNVDLVLYELKEYSTEVDVEFVKKSVRAIGNCAIKLPQSTEKCINILLDLIDTKISYITQECVIVIKDIFRKYPNKYESIITILCENIELLDDSNAKASLIWIIGEYIERIDNAHELIESFLENFLDEPYNVQLQILTSSVKLFLKSSKHTKDIITKVLKMSTEESDNPDLRDRAYIYWRLLSKDVEAAKKIILTEKPPIHEDNVITDTKFLNKLIKNISMLSSVYHKLPETFIVKRSNNDNDINSIYDENDETNDENLDSFDNFNISKIKKKMEKHKYDTSSSPNRKSNHSGSSSASYNNSSDSDDYKDDSYDNKKNIDLIELNEDGNNNNNNIDDSKQKKTHPPVKLTQVLSPEDAGVKGQRGLSIMASINRVDAKICLKIAVSNQTPNPLIVSGVQINKNSFGLSSPNPIENHNIFMGETKEILVLLAPNILNSNTPPTFPLFLQVAIRTNIDIFYFNVPYDIFIVFVENFNMEKDIFKKKWKLIEDSKEVFIYGCRLYLLHFVHNFPQFFSIFFNFPQFFPSIFRHASEHFDGHKSNRNNIRHIDKEDENFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PV60</accession>
    <name>V7PV60_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="TLDc" evidence="8">
        <location>
            <begin position="1338"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="882"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1011"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="905"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB63025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1501" mass="177175" checksum="70FC4497DA527239" modified="2014-02-19" version="1">MDKEIKHLLRRGVSDSLKHLIWIRSNDVNYFVINFPHFYETTIYNTFGDKIPSNLSNDCPTFCGGILGLQEDIMCVQTKIEELEIDNNDDYNSFNINDSTSNILKLLFNNPNDMEKKKDKYLLPEHNFWKEPKALSTPNFGINNNKPKKKKFQYIENVKNKILKNKRIDNYLRVASDSVLPYSRNFILKNLSNKFSKLKLDKKNNGEFSNNINLNIYECCNIKCNYDISYRDQRECSNDVSNLMGSELGKIDSNDNIDVSNKTVSSDKKLGHEKNNLLKNCSKTERDILIKDDIIIFHNNETDQNSNKLDVVSNNSFNNSRTNSPRNSQNNSDHNIHSIYCKKHKLHGHHQSSYQLSTRENENFESNKYLHIQTYMTEQYIISKKQAEKMNTAKLYLRTKRKKKKDNENNLSKNNKNTNKGMNRHNSDYSISSTSTEQFLNKKTIENIYGKKKYSSYNRTKQFLEKTFNVTQSNKKNERKLSDHISSLLKKSLNTDYLTQKSTTTQFHPKHSNIYFVGGKDPNNSDQSSQKDAEKGAKNVEKGAKDAQNSQSAQSLQKNFKRSNAFKSNNINTHLENDKLKDDYKNINDSFISDFQNNKNMWKSKEGDSNSIVELSVFNSNEEYKKSENICKSLESREKYDLKKGDKNEKMSTNRKSIFSKLKYMFYKKKNTFENYDDEFSKYEQDEEDMASQYVNIPIEKYNRQVYFPFEKNSKIESTTPITPSTTNDNNKNCDSINKTDSFFGEFKQYNEIDVEKKNKNSKHFIEPQNVDVCKNEKTETKQNYTNENKTLNKYNIIISRHEQDNDDNKSIIRQCNNKYYDNRCDTKCENILFENDKYSNIYNKNQDNKLNDISYSSPQIETHEYFSDDTQYHGIKIKKVNKKKEEKDEWNQNNNDTMSRIDNDSNSDNTTNKNNFENFKLPKTHPLNEENEKDESISTESEDEEEEHNQNQSPQKKIMKKKKKIYFKDISESEENEQIHNVTKFNKQIGDNNKREDFLKIRDPYNYYGEYNLSDNREEGGGRESDGKGEWEKRDPKKDPKKKRDEKRDEKCDEKRDEKFDEKRDEHDQGGDKNLENELYNKFYEKNGNNNWDYPNVYNLDDATEFSQLLNDNGKHEIKKLLWAINNNFGNDIEFAPIIPNLCIVLLIYFKASVVYCIIHCLIKKGIDSIRNKELPFFIYKRKDFVKYVKYVLNSFIKFLPKCYYYLRKLNFDLAAWTARCIQDGFARMLPFDFVLRIYGTFLFEGQKTLCLYCLALLKFLEDDILKCSNIEEIENILYHICMHPYLDINKLTQSAYRFKLKAKENHLQLSTKCPSPYLMNVKIKNFYRPRLNDSSRIINSFHWEKLWEKIPSNNRSLDPYLTFCSKKDGYNLQKLLDKTEKNKKKPMILILKTFDYDLIGFYCPFSLNRDYNFVSLTDKSSSFLCTFNSTFKFYRWSGKNNTLILMRDGIYIGGNDIALFIDRDIKVGKTNYSESFSSPPLISNGYDFNIMDIEIWNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PV62</accession>
    <name>V7PV62_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YIR protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PV62"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01590">
        <property type="entry name" value="yir-bir-cir_Pla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB63461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31940" checksum="4C1D9448D808633F" modified="2014-02-19" version="1">MSISKVCGEFTTFWKFFPDELKGSEYDFKTGQHVIKYDSVCILIWLSYILSLKSHDGIKTINNFYSSHIENNTEYSKHKINDQKYTDYKKIIDETKEYMDINISNMPKFYKLLKLLCSMNTAYTTGKSNDFSEDAKKFADEYKELLDSDNNNNGNSYNKILLVLSNYYNNIETGTRFNNTSITRPKLPTEKTPKKDNSEGHEVTKVTEQPSETGKLGITTATPSSDITVSDSSLVNKLVIVLPILAAIPIFLGIAYKYSLFGFRKRSKKQHLREKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PV65</accession>
    <name>V7PV65_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_00628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PV65"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB63030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="440" mass="51964" checksum="8552B292DA47C026" modified="2014-02-19" version="1">MPRAEPGTPKWLANKMKAKGLQKLKWYCQMCEKQCRDENGFKCHRLSETHQRQMQIFCQDANKFMDEYSSMFEKEFMRLMKTKYCRARILANTVYTNMISDKTHIHMNATVWVTLTDFVLYLGKTGKCKIEQTERGWYLEYIDREKIEREKAFNKKKKIEYSYEEMKEKKINQVIEEAKKTGQFIQSEYTGIEKKNDDKIIISSVKPTNTNPSTIGHNDHVPKSNIFLDILKKNKIKNTNDQLKSENIKKEEKLSKDKTQNKKRPISSLELLIMENEEKKKLKNLLPNLNKNIKDNNSKTEHTHSIAKQVNERDEKGGKNKKREKDEKSEDYEKGGKDEKSEDYDTWITKNIIVKIVDKNHKYYKSKGVIISISSTEKNKCEIKIKNTTKYTLAYQNQIQTVIPQIGRMVLILKGRYKGLKGKIKKVFFMCTHFHILMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWX0</accession>
    <name>V7PWX0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_00706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWX0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="6"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB63122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="183" mass="20877" checksum="B8CFB480387D7B8F" modified="2014-02-19" version="1">MTKKKIWIPIESNPDSLYLYSCKLGQQKLSFVDIYGFSKDLLDMIPKPVHAIIFLYPIKDDIDNNIGSSHINTTNDDSNIWFIKQTVSNSCGTIALLHLLANLRNTFPLDKDSVLDTFFNKVDHLKPEGRAMEFENSDIIEQLHHEFSGNELNSGESIDVDTHFIVFLEINGMLVELVSQNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PX99</accession>
    <name>V7PX99_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PX99"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="975" mass="110841" checksum="3AD32A3A622680A3" modified="2014-02-19" version="1">MKKKKKSVDMHIWKDALNDFEVSRKNKYSLTQDTIHGRLRPEPEIVEHVLEELEDKIRHYFNLYKNEKEKRTNSESNNYYLQKEIYNAYEALDKNNMYTKKLEDKLENIKENQSSLIDTVRRIDLLYIQLDTLVQSFAGVCTQIASDTAESSDNINKKKKTMKMLLDYIYPCRTLDPRINSLYGMLYYQSIGLLKDGKFISPPIPPIPPLVPSEDLNGWLPPSDYVPNHQIEYTNNGDLVKSMSSGENKNSFSDLIKMYKQGNNNDSYEEFFSKYIKEEQDKLENNENVHNVLKISNDGNNNMSSDQNGYLISQDLQSFEININNLEIKYLNGNPKIICVVRYDSESAISAIQNTQRVTRPKDRIDIDSNVDYLTFNINSRILLDKLPEKKTGDIPSFMIDIHDVSGKVLVGTSRCSFISEKTLINNAPWDIYSRLNKSKPEIIGKIYVSVYPKPNNSILPAEVFKNLKRNNKNTNIMHKLNPSKATQILTNTHNPNMVNTDTKIEYKTVKVFQKNAVLSKAIYEKDQEPIPQLEKIGPNNNKTTTLGKRGQKVTFKPYVSKSDKNVESEEKKPAEEAKGNEDKSKVTTESSDTDNAKSENEQTTSVMSRIRQLTMKFEAAKNKTEGNQNNTPLKLPFRVKGKENNDEKVLEKNKSVEKNKSVEKNKSVEKNKFAEKGKTAEKGNIVEKGKTVEKGKIVEKGKTVEKKQFPVMKDGVMKVKLVSLGKTNVLKDDKTKEEMKSDENDEDKKTDEDKEDKKMEEEKTPIDVKKISSVNKLKPALKMKIGPNKDNLKKILASKQINKEGIEKASQIGQNKISEEKEEAKAVEKGEAKVVEKIGGKVAEKIGGKAAEKIGAKAAEKIGVKTAEKETIKEKMLSMFKAKKSKAEIPPKEIPLSVKLGDAAPILKKPIMKPPPPLNESKSSNEDPDLKSILEKAKKKAVLIDKNKIQVKLPKKFEMKKEIKKFVPKLANVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7P9V2</accession>
    <name>V7P9V2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucose-6-phosphate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="2">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_05625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="2"/>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7P9V2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="8">
        <location>
            <begin position="36"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="320"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="490"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="592"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB56144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="922" mass="106830" checksum="5BEFFA049DB4EECC" modified="2014-02-19" version="1">MEYETFLKCLDEIRCVNNVKYMETEDLTDFNKKSAYYICKEIYEKQLSNENGYVVIGLSGGKTPIDVYKNMCAIKDIKIDKNKLIFFIIDERYKNDDHKFSNYNNIKFLFDELNINKETQLYKPDTKKDLVSCIRDYNEQIKSMLEKYKKIDIAILGMGSDFHIASLFPNVYYNIYMNNYQNNYIYEDNETIRSLNADNNVNLSLLNEHVYFTTTNNFDVRKRITVSLNLLSNSTSKIFLLNTADKLNLWKNMLLNFYVNPNYNLYPAFKVIDSRNTTVIACGHKNYSKMLEDLYVQKDCALSPVSNNNVENKNELLTIVIFGCSGDLAKKKIYPALFKLFCNNLLPKNIIIIGFARTEQDFESFFNKISIYLKISLNSYKNLSVFEKAERLNSFKSKCRYFIGNYLSTESFENFDVYITQEERIALGCFGQKDNGCEPPMPTDSPKRCPYSSSYSNTSGNATCPHSFHHSVKPSNTGCPYLSSQANTSDNSGCPYISHHINKSGNSGCPYTITRMLYLALPPHIFVSTLQNYKKYCLNKNRITKILLEKPFGKDLESFKILSKQILEAFPEKNIYRIDHYLGKDMVSGLLKLKFTNTFLLSLMNRHFIKCIKITLKETKGVYGRGQYFDPYGIIRDVMQNHMLQLLTLITMEHPTDLDDKSIQNEKIKILKSIASIKLEDTVIGQYIKSNNDDTNNNNSNISENANIDKSKINHSYHDDPHVDPNSITPTFCTCVLYINSINWHGVPIILKAGKGLNNDICEIKIQFHNIMGSSDESMYNNEFVIILQPVEGIYLKLMIKKMGSEEMEEVQLNLSLNENNNKAYVPEAYETLLSECYKGYKRKFISDEELYESWRIFTPLLNELQEKHVKPLSYPFGSSGPQEAYDLVRKYYNYGKNYDTTAKFCRKSSYYDDSLFDNMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7P9W7</accession>
    <name>V7P9W7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_05637</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7P9W7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="89"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB56164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="180" mass="20868" checksum="5605E7AD88397517" modified="2014-02-19" version="1">MCYIIFSLAKEKYYLMKDEIKYLNKDVDDLENSIDVVKKNTHKFNISNEEIENRTKSLKNIRAILNDVASDLTNTALSPNIYMMDDYNNIAINKQNDDLEVLAESAERLHNAAITINTELKDQQRLLDELENEMDNSNEKMNFVTKKISDYLQTNNPKIISLILYLTGISFFLLFVLVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7P9X8</accession>
    <name>V7P9X8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_05786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7P9X8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="136"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB56356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="720" mass="86586" checksum="514C46A8DAAAF1D3" modified="2014-02-19" version="1">MFFLTNPFEKKKNNIIFRAKLEEKLNEYLCNGTIISRDNFFDDEKKKIKQGDISQIKITNEFINNCNTNLLINILKINKKLKVCYDVKYNVVYSLLLKSFEKRSNICINTKNKKCEPMVNVYKIKRKNISYFMNQYHIIKCIYSSEYGNIYYCKNVIDNKKYCIKLFYLRLCLKDNCPYYINNKVYLTNYFYKILSEIFFLNYLENNNIINIEQIFCDEKNEILFIIFPYIKHQSMYYKKKPKIYSIYNKKLVRLENKKFKIHLYSENFIKYIFLNIYNTINYLLQKNVAYLDLKPDNILLTHRNADTIESYEVSFTKKKKIEKLNKVLISSSSKEISNIEINLHTKFKEQIKESCTKDEYIKNAYANKMFLTTGKNKKTVISKNNICYYCSYANLKPEKLKKNKKIKYIYNVNLSKSFEYDKTVKRIFFTKNKLDTFFFAPHNTTTFIQTFIQQKNKHNKSQNNLYKKYEKRKKTNNALSPNKTYINKIKNLSIFKYNQKHSINFLKFYWLYFNIGKSCDINNDFLVYLDLYFFNKYYNKIGNMCTDVLYMTRNQYIELSTIKAHTDNIHEKGKTENMNDNDKNAYKEKIQNHDIIPTDDTEKQSCLSNNKINYNNSIKLIDFDACTFIIKSFNTYTRETDIFNSFESLFPDINKTIELSKKQAYNFGSVLYTFLFGIPPYHGKDIFEIYNNMKNNSLYFPKYRKINNDLKKLLSFYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBI6</accession>
    <name>V7PBI6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_05291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1195"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1934"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2049"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2143"/>
            <end position="2162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2209"/>
            <end position="2229"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 N-terminal" evidence="4">
        <location>
            <begin position="298"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB56931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2258" mass="270739" checksum="0413B368D890C42C" modified="2014-02-19" version="1">MDEVENLIEEYISPEQAMFRYGKEKKIELIYEKNKDKEETKIRNEILKKLVDFIENDPQKNVEETNEKTEKHEENDCTFSAITTSVECKNDMTCSEKKGLIDQNKKNRKLIDIIMYLKKYNFCNENIKRGTSVNLISQLFEEIDFIELEIEYFRAIINFFIKKIEDWHCINGVLNFFLIIFERYKNKLEEMQYCDEITEEYKKLFISKNKKEKNNMNNNDNIYDKNKIIGSENDEINENVISNYYNNYNSENESNESWRSSYECQHEKYNRRYNDFEEFENEEESENEKIKENSTCIVYKIMKTIFKHIFAPSYLQIVRFKYYKIILISLEHFKNEIINIPNFINKIQVQLEGESDPRNILVLFEIIYILCNKYILPLSSKSPMINIYDNFENKDDEIEESDSLFSWKKENEYLKSLIDIAFYYFPIEFINNDGRYDFVSEQNLQESFIKCLKSNKRLGNYIIVNILDHFYNYENEEISEKNLKNILETLKICVPFYGVDCCSQYISTVLGLIELECIENNNDENMINYLIEILIIFINLLNKENNNKKKYNLYNKYFINIFKKFQTYIILHRCMYQGIDYDISNFVNLEKNDIFSNSDSKEYINSFFLKNEGEGEGNEQIYESDNELHIEKEKIKMSKMFDIFSDNIHDTDLSYEWDVSEYDQSVENSEKGSEKGSEKGSEASDDKNILSILKEKNEIEKMNEEKDKEKKKNKIKVDKFYVIEKILTHIASSNTYICLLTLKLIIVPIIKECYCMIKILNLQNNNKDKEKIWNLFVIYINFANNLIEKSIKIYDIVSLKINFIYEIYILIEIFNNGKNDIFYNYHNSGLQIFNILSNFLCMHYFDNKKKKKKINYFSEEIKTVNNYKQVDNWEYLLFYKSLLSFFYIIEFHPFKVRSQIVMLYKEKENGRKINGGENKEVNMNNFEFIDIWRNGIVKEHANYVNDIAENNENILHHNKNYKKNDLFYFLILINKIIKYKYKYIQNYLHFILFNLSFFIIKLYHSKDQNYQNYQNLLTHFYDVNINYIIFLITNIYSFVLKYYYNYVSAIKNSFLKMNKTDSIHDIPENLINNDLKKNGILYNSQNGDSNCDEFVCFYLPNSNKKVKKNNVDIFGETFSKDSESSQSNEYFRNFIKECNGINNDTFLKQNMFKYGSKLIPNLFCEIENKKKNNRNEKIKFNKIEIVINEKIKKDYIIPFYFSFLLYICYFYTHNLYGKIQNFEENPNEVNNKIKNIYDNKDELYSSYMYVNIFEIVELCIKYIYEEKIVREIFIDTLNKKKEKINNSNNSNNSNNSNNSNNSTKYGCINLINDNEDLYYYSTYINGLTNFIKLNEIKNVKIINIIISMLEDDQNNDLKDCIISFLNKFFFFTNLLNIEINSFLYLLTEIALMCDMNYRHDQHETICNQHETICNKNIQNLKKLPTYLYNKAKHWVNHIFIFLNPDKKSQFLKNIITISINSNGLSEEKYDKIASQDNYIFIQKNKNLLLKNQPILLLFIPYLLSSHIYIEEEDINSLLKFCIYIFFFNIYKENFGIKNDENLNPDGIEEVANEPIENVDILKKYKIENNSTYLKDDIQNIKKNLNKINYELFKNLYKCSLTIISVIFAHSYINKEDALNFIYQHFDDIKYLNLSTKSSLLYKNIIDQFTEIFKSFIHIKKGIKSGKNCNNFFIFLSKIFQVNFDQNYYQTHDFIFFLFDQLYFNNNNAKIIETSNSQHIDYEIRIVATSYFKGGGMEEEKKVANMSGDKIRYNWECLEEIKRGSAKSNSPKTCAIRLANLKAIISKKNNIEKNHNLEKNSHLDGVDKLESAECEDFHLNCHLFFSIYQIFQTFYDLTFYIKSGEKNSTEMDMGENVENVENVENVENVENIENLYENVNKECEEHTYIIFYFHYISYIYEKIYHIIHHIDTNTFFEEENYNKIYFIKNLEFFNIYKTILINFVYTLYNYLYFIQITNKYITITEFLFMLNDWNISIKQSLSYNYIKENEKITKFINYYCLNGKICQNDELNTSSSLLDGEDKECKNLTENNKNILQNLRYNKKENRNKYNCKYISLIHIMSIFLLNMTIEQVLKNHYNVLKLSILKGINKVANFFINKSSYLYNNKRYINNVLRKNINIVKDIFSDTNKNCKNEEKRVLVKKIISLNILCCLRLLYLIFKLLNYFLKFENKNENINLEPYDDKKKNSVNNQLQFLLSYKNIIIKSVMKIMISVPFSLVRYICACIFYLLSFYNYQSFLPYSIIQDVSHYYYILLCVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBJ0</accession>
    <name>V7PBJ0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_05163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PBJ0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="16"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB56784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="757" mass="87624" checksum="0681A9E2193E4C0A" modified="2014-02-19" version="1">MIRLYDIDNLSQIIINKINDILSKIINKTYKKFKSHPSFWNIINNVENYKNHVNISTNKSKFSNNIINKKKEKNKLPKMDKSIVYIEYAILYECCSIYKFLDKKIDEKNKEMLINLVISSLNTNKSNINYIVLNCLSQFKITPYIYNKLEKHISYLIKLLKSDDITIKLQAFNILFNLCNASNWKYLINIFLQHLPYVDPYIQNEIIIKICILAEQFSSNMAWYIDIIFKIIETTHKHIFKDVCYRLVQLLTGFAKNKKNTLLYKNGKSDNTINTKNNNTPKNMNNKNTKIDNNDNDEEKKIQMYAAIKSYRYLSKNICKIELLIDLCSYIIGSFGYLIKNKIPMKSQFKILEKYFNYTTINNKSVILLAFMKMLFYDHKLISNVKKILSDIIDHPNLELQTRACEFMNLCNIGNFNLINSVLKTMPLYNTKKIHKNFLIKRLLETNKHANIYLLENDAQLTSERVNNKNKSDKYNKFDEEEDKVSNYSRDQIDSNLSYESYSKRKSQSASSDSGSASGSASGSASGSVSGSASGSSSGDSNKLHDDLSSKSKTSDKDSDDNGNLFKMLGLQKANNINELWLNGCLLDKCLFYKNSVVSILIKQRYQENKAILNFYIKNISKGPIKIVSINIEEPEQIKIKEQKNINNEIINADEVCEYKLNVTVSDIFYVIPIIFFNLTIPTSPNIIFSSKLPILITRFIKESKINETSFKIYWKGFTQIHSEDIVMGFPKHSKKILINYLTSAFNLYVLKVSQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBK2</accession>
    <name>V7PBK2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_05301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PBK2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB56946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="147" mass="17625" checksum="0F88CB4523C4F73B" modified="2014-02-19" version="1">MAHFSNFIQKCQFEGCRYHDFLPHKCEYCELMFCELHKKAQDHVCSKLKHSDLKKVILCEYCNAVIPDEEEEIKWHLIHKCTYIKKATKPKICDKEKCKTVLNDINSYFCKQCKKTFCLPHRYDFAHKCISDNKYKKGFFESMVNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBK8</accession>
    <name>V7PBK8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PBK8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="2">
        <location>
            <begin position="61"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1045" mass="122290" checksum="165D5FD99BFBE8EE" modified="2014-02-19" version="1">MLSSEENINNNGETDQVCLEGEFENKAEKNNIQKYESKLNPIAPEFKPQNSLYIYQKIQQHTKRNIILLIKSFGYKGIKLEKISGEYCKKYNAVLNLGQAGFTNIYDILKSLNNCLIYEYEEKEDGYNNNNEKKNDNEKKNDNEKENDNEKENDNENESKTDVPVAKSNEELERNLIIKYKTPKMNEDREFFVKIILGTIAEYTNYDPKLSNEETPLNNNLSLNKLPQEIKKIFGQTFNIKALQIRCGIYKLQTFLEEIQEIDIFSLSNDIKIRITPETYNSKIPQLKNIKKSMTSNELKIKSLYSRFSSKNISNYNQYNENKTNIKLCDENSNIIKKTASQNNDEKNIQNKIDKLDSIEIIQTINSRNNSISRKNDFLHDINSSLYNSKSCENNWKNLFLGQNNNQLFENQDLSYMNKTNSIDKFEDDYIDKYDTKFSANFSRFKNTHDPIIYQKGLVNSHPNYFPQFKKDNENKNLLPKILPKAQLHILLFQLIVILSARQKIEWTEINKIKEQILRSGNETNESEESPNKNETDTKSTVEEPESYKKEKTNILDILNNSGTTVSSDYLNGSYKTQDTSNMYKHEVLSSDMNTKNSHFFNSNELDDSENELIGVFVSSIKSEWNKTYSEQYPLSFYLNYYKTKKLKKLLEEIPNLIIAGYGRTMQVITLDSAQEYYDNLFSDDQNNFKAIAKSKFTSLSSALYFKDATYKEIAEECINGDTSNVFKILEINYIKLSNSNKNINNYNFINNENIGRNFSKSMDNLIDDYNLNENRDKYYGHKNYNKKKNLEILRYHLHKLLYNLVIHVCKKQNSLFLKYKENGIILNEQEINKQLCSPVFYPSDLTYDDFIMPKQNFIQKYNIAKNMHILSQYGIYGIKLIHLPNEWFNLYKCELRPLMKICNYYQIGKMISTMSNLLVVNEGFDTKYIPNTNLDSELGSFNDLSFWDSVKKTPDNILQNKIFFPEPHNGNINNPPSKSPAYESIMGILFPNAIPQKSNKFQRNNTTHIRAFRNYDYKKNKSSFPGSYNSYKNSISLHNLFRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBM4</accession>
    <name>V7PBM4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PBM4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="585" mass="70121" checksum="0C4227611769A100" modified="2014-02-19" version="1">MILKKGKNSSHKYMIKDNICHRCFIKKYIDYPNNNKIKGCINYPQKKIIYNKEDLIKCVKYISKKIVKILKNSEIINICFVFKYNIMIGFQNTCIYLINFPQCNIKKNRIFYNDNNEKTLLFLFNKRIVKSIKSVNDYSSIIFPFSISKECQKPIYLKKKMISYIKNVKFKNGEMAKHEKYNKKGNIFNSFDESCKSDKYSISSKYKKNNETKFEGKVSKNHNKNHNKNIEWGKSKKEDILKKYSKREIIFHMHLFELLIRLVFEKTKTYFVFFINKKTYNLDFYKNIYYLNMCKIVNIRICGKDRVKKENKKKECEKKECEKKECEKKKILEKLRDENNNYKKIINEKDKLITNLENEINEKNQLVSNIKNEFAKYKSENSEKIKTEILKRKESKCIISKNDSTIITNNTNQQLLKNNNYIKKLYNENNLLKERIKKLTKSNDEDVNTNHDKKISDVTKLSKLCLYENEEKKKETEKCDKLIFYLKAFLDTEQKLYTADVVINIQANIIEEIKKEQKIYFENIEKNKLILKKEIESSFDFIYSVCEDIQTKKEKICLTNRINKLQDCINDFLSHLNKSTKTEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBN3</accession>
    <name>V7PBN3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PBN3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1070" mass="127594" checksum="980981009954857E" modified="2014-02-19" version="1">MNIFLPQEQSIKKHDTYLGDNVEPVLKIKKIRWNKKKIKLEKELLQKYNYVDNYYSHGYCTRITNNLMKKFKKERINIYDIKTKKMNNKAKEDIIEEENLRKMRLNNLLRLSENTIEEQNNYEQEMENKKEESYKTDSYISFDDLDNRSINNLKKKYKMLKKSDNDHERDLKKLKFYLCKKLNKKKYIKKPMKIKKEKTKKEKIKKIIKYSSKTGYNLLAQLQKGEIKEESEEESELSELEEGELFDDQDKNTEDLNSSEYTYSSLTLSFSEYLNIREAYYNDNSYEKIFYPKDPKMNVTYIYDTVDFYHISKGKTLNKRHMLMEMLIFNIKFYERSNFIKEEDLSYSFEINENWKTTIEKKTDDIEELVIDMGNNNENNGIFGLSGDKNKIRIIYNNINQRMLLAKYIKYLNYISSGTIDNAATFFLYETDTLDLRNVQYDKVADSIICLHLKNLKNINNVNIANRSMNVENLCEFLSLPNIKQYSTLNLSKNPLFLDLTFDSKKKDIDCVIDIFKKNVKLNELIIDFVDLSNPLGEYFITNLLLNTSITFLSLINCNIGSDNIKNIINALEHRKVNTIYPINYINIEFNNLTYYDIIFLIKTLCTLNKNFKKLYICGNLVQENIFDVSFAFRRKKKLIEMDKYNKQVPDIFHFDNIYDVKNNLFCNLKGTAELTENSKVSNVTFELYLKYLYIMPPENKLYTIRNITTIKRRYQRFLNIVALHDKKEINIQLNLFSENHVTVFNNLIKKSFHAEMYYNKQVNANKIVNKNILDYFSMRIKNELNFYHYNVTAEEIHYVLDLCKKNFVKNINLSCCYLTNDDILYFNTIKNDSYKINVYNISLNNNLFTSDIQIDQLIKFISNFSIYFKINLNNLSIGANSSTYKLFFSILNDTKSKIVMLDNCNLGNSFLFNVNNNIQDLNTNDYLNVLSMQYNEFDNKKEMLKFLNKIIIKCKQIKKIKIFSNYVTEEEIKFITKHVLKKNIVSFEDTYDVSSSYKRNRKFSKLSKKINYIDYNTELTPDEMKKITEFFQKEQKKGINDNKHNYPLKDRYHLSDLKTKNIKNSFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBN4</accession>
    <name>V7PBN4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RSE1/DDB1/CPSF1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_05201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="863"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="503"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB56829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1444" mass="169328" checksum="1FCD052AA64986B4" modified="2014-02-19" version="1">MLHKIYFQIPSIIQTIISFKYFKINSVCTSDNEIRHNKIDKKDGYDIKYILINFDENMNLSYNTDKKGILLCLTNLSIFKNQNSNKFHEQYQENQLKRNLLLRECSQRLSQMGGEGEKVGEDGEDDKEDENGGDGENVGEDEDGGEDENGGEDENGGDGEKRPTSSIDVDSYENVIYALKGEEKRRSISINDIKSIQDCLNFFKSFPLIHFNIKDVDKYVKKIYLIHILREKEENWNSNSIIHEIDCIKYVLTKKFWNFCSTSSNNNNNKTWNTKKTSLILNQKSISILRYNKILIQICQNEINIFYYNNTYILLKQILVENQKVIISSKLIKHYLIILNNCNECLIYNINDDILNLMINIIEEFVSIFNSCLLHCLLYDYTDESVNIIDIVKFIDVEKIFYNSSEISKLLNIQSSSMFLKIINKKQKNSDHFIILNNQINNTRCISIIEKNNKQFLSFLNIINNTFNIYDLETKQIIFESNFLLNVPKYVYKTSPPRSKAKKNRMKSEADAEAEAEAEAEAEAEAEAEAEAEAEADKRAQFLSLYKKEEIINILFFKLENYYLLIIFMTGRPIIIYKSFSCSNFFKNLKFKIFIHNYIKPIPSNIHFVNNPDKVSPDKVSPDKVSPDKISPDKIVSTSRHFESNNDGYYIYVCKNDHNKNSNFKNCIVVYPYIDLKKIKINDQDQKIYFYQNILNNYDTDFPILFFSSYKGKLFIHSFDTTQMINSTFCDSHVKKHKSGGDGNYSQTIKGVKKIGKNLFLSFSDNNLSIFSIGTEKYNSIEIIDKNGIKINNMDSVFPFSNKLYLNKKNVYIDNTNSLIFFKSSNLINLKFNDNFISKLFVSYPYISKFAVSQNYYILKKKKNNNNNNNKKKNSDRNSGANNGASDDASGDTTKHAVTFGKVICLIVRIKYDEYYNLKKNLKKRLSYQKDELKNNNLYENEDAVCIPNPILSDCVNNQYTHLIKRFIDDDIETTNNLNDENKKRKNEILIQSIKTKSKYYKLLLLHENSQNIYGYYIFEHSEQIHSISFGQFNNTEYIFISTSLNINERIETQGNIYIIEFSHIFKLYDTNLFIDNLFVNEKKHTNLDSADEKKHTNLDFADEKKLQNKIDHAKNAKLVVYMKKTYNSSVTHILPFYFYSETNKQKYKKISNDEIENKFEIKWNNDKNENKWNDNNYIYSSLLHCTNSKIYIHEIKNNDFIKGAFLDNNFYISDIKIFRNFIIISDLYKGIYINMYSYEEQYDSRRIISISKTFYNHNLNILSCHYIVYNSNICIIAMDVYNNFFIFGHKNKQDIDNLYIYNYFNFNRRILKFINELHQNKHSNSALSISNDGSIHIYHPLNDKAFIFFKHIFKIVKKFIFPNLALNINSDLKPDIFIQSIILNLHKKTDSLLAGNVLFHDLLRQIPFYSSEVLYELFCQRANLLNNITIADLINELYLLGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBN9</accession>
    <name>V7PBN9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_05203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PBN9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB56834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="195" mass="22200" checksum="EA048F0CAA3EA1DC" modified="2014-02-19" version="1">MVILLDKLEVTDIVLDNNDMPEKKTQKINYQIENDENLLAPWLFSCQLGTPLSSLQVLLEFSVQTTIELNVKLWKREEDMWVNFLEAISNKSKNYLPETLDLLDLRKSTRKCLLNLCTNENLIVLRNVPGKAQAVYNTTTMTLVAILASAIYEAWKRIELTDPVSLGRIVLVLDGEDVGSRLRAGNKKLKIEPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDL0</accession>
    <name>V7PDL0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDL0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22667" checksum="38464FF08C258718" modified="2014-02-19" version="1">MTGTEITIDNIAYAKIFMHALKNSYNDVCGILIGKYYNSENETKKCIISNTIPLFHTHILFAFLSLAFTMIEKNCKESGERIIGYYHISADDSKNDNISNIKICDVISDTLIKNYNDALICLVKISKLKDDEDNCIKTFMQDGNGKLKNAKITISNKNKEFLRKSISNHEYLNIHDFDDHLNCINCDFMNPNLFKDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDL9</accession>
    <name>V7PDL9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_04929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDL9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02619">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004763932" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="612"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="916"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="926"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="941"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="967"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1009"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB57085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1189" mass="132387" checksum="DEAA3AF6E618F166" modified="2014-02-19" version="1">MRRLPILFILYALLIRNSKEGGLGVNGEGDALTSLPTSGGTEGDTSGKKADGSLSPGPGPTEPGGPAPVGPLPGSPQVEEPKLSTPSVEGSQLESSSLTKDGPKAVGEDGTLISGTEQEGSETDRTKQEKSGSDNNKQGGSPPGKPAGETITQDPSQQKIVDQNGPVKEEPGPKGPVLPPSSPVSTDQDAVNTLESLQSDSPSAESVPSIIESIPLQNFDIKSAMLKNYKGLKITGQCNSSFFMFFVPYVYIDVDTKINQISIFSTKKKVNGTTNDVPTQLIEFKSENDNLQNQCAENKTFKIVIYLDNDVFYVKWKVYGPSTETESNTNVDVRKYRLKNIETPITSIQVHNVKRTSKNITIESKNYTINDDLPEKCEAIASDCFLHGNVDTEKCYKCALLYRDTPITDKCYDYLPNDYKESLKSDGLVTAQSEDEINYELIGHIDNVLEGIYNIDEDNNNNKELKKFEELDDEIKKDMLLYCKELKESDVSGTLEEYALGDVEDIFYNLIQLINNNTGVVISKLKNKLMNPAICLKDVNQWGEKKKGLVLPELSSNNFDNLNDKNDDTTINSKLDEKLEEEGFDGVIDLPLPHENEFEGYTTIEDFQYCNNEYCDRLKDNNSCISKIDVEEQGNCATSWLFASKFHLDTIGCMKGHENFSASALYVANCSKKDSKDKCLTGSNPLEFLNIIDENKFLPTTSNLPYSYKKVGEECPKTMDNWTNLWKDVKLLKHENNDKSLNANGYISYQSKDFKDNFSEYINLIKQEIQNKGSIIAYINSKDIISYDFNGSKIHKLCGSDTPDMAVNIIGYGKYINENNQVKSYWLVRNSWGKHWADEGNFKVDIETPENCEHNFIHTFATFNIYIPFVKKNIPSESEINLYYSKNSPDFYNNLYFKNLDAVDTNKDSIIEGQNEPAKVADSEETNQLTGDGQLTSQGGETKELPGPTEEKTPKEGGGSEEPSTDLQGKTQELKQQQQQQQQQEQQQLQSHPQPGPQPGPQPQPEPQPQTKVEGQEQVQEQVQVTDGVQAAGKQVDGAGNTGHLAGQEVQKETGTTGASSKEKGPLPPVNPSEGHQAGKVTEQQADQPSAQAQPANSITQLQAVKIEFMHILKQIKNGRVQMNLVKYGDELNMIDDRMCSRVHAINYEKKDECEKFCANHWNECQYEASPGYCLSKMYKSDDCYFCYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDM8</accession>
    <name>V7PDM8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Maestro/Maestro-like HEAT-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDM8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314:SF0">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="1">
        <location>
            <begin position="126"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="462" mass="52375" checksum="C469259DDAB2D59E" modified="2014-02-19" version="1">MSKVIHQIFDDYNRSRIQFTQSISDLCLKPHNIELLVNTDIINLLRPLILDKVPIVQQNATVILAKLASYSEEVALTILQNDVLPHLIYCLKHENKNYRKNCAYTLKCLANHNSKLANIVAEENCIDYLMDCLDEYDLRVKQSCINALCAIIKNDLELSNNVVDKGIIPLLILCLQEKDNNLIKSSLNMLSELCKHSDEIAKNVVDNNVLPNLIKFLDNNDNYIKKNACNCLSQIAKHKEELTELMIENDIFPKILYLLKDNDDIVKKNCANCLKEMSKHNEDICKIIVRAGALPLLCECIEQSSKDTIKLPAILCLGFISSFSESLSLNIILSNTIPILKKSMIEETEDYIKSACVWTVGNIGKHSTEHAKKLADENILIILVNLYNSNESSDDLKKKVKIALKGIIQKVTDLEALHPVFLKSPLKLAKYSIFQFSKILPKNPSYKKSFIKSGCLKYLQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDN7</accession>
    <name>V7PDN7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051483">
        <property type="entry name" value="MAP7_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073:SF1">
        <property type="entry name" value="RETICULOCYTE-BINDING PROTEIN HOMOLOG 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1482" mass="175622" checksum="0C515B8172EA6D02" modified="2014-02-19" version="1">MQLFKGLKNYIHYLKIQNELKRQLYNVDHILLIKNSIHISNLFKFGNANSVCGQAGRSGKRNGLVKNDEDNYAKKRDDDYENKQDDDDYAKKRDDDEQNCIINKNILWGNTSIINNMNSQVKKKIEIILHSYKFKKINICVQEILEIVNDHPRNKDIYINKNLLLPFYIMLIKKGYYQNNLKNNIYDNCFINIFDYIHYNINEHLNFYNLKNIHELLICLSKYLYKNNSNLITENLIKNIFYFSFFSHFNTFNYKTSPKNNNNIYGNNKNNNINGNNKNNNNIINDNNINDNINDNINDNKYIDQTNLKKKKKNSSYECYLDKNNNQAIKQLNTKKNINDLVQLCEKNKDNKLEGKNNLLFSQNQHYIYNNKKREKKKYTYHEETFFYLKSYVIFLSNNPKYANKKILSNISTLANKIVDLKINSIMLLSFLSAKLNLIKKYPEQNIINSLFLNRTANYHILHTILKSFNLTHAPSQRIKCGEKINEKINEKINGEKKDEKINGEEDGEGKYSLWRCSHIVNVIKILKVKNILVSKAFKSDENGERCLQETFSNVINKLDMFYLNNNDNNGNFVGISKNEIDSFFCIYINLSILLNEVTNKKDIFFLISNFLNNSFQSVYIYYNNLHINMLINLINGMYNQLCAYNKINIYDIHFENVLNKHISEEIDSHHIIGSTHLMEINSKSNLACNPINKCLHLVNDIGTCLLHSIQEQNKMPLTKLVTVLNYIHKINKMFNIFNILIFKYIDQIQKHVGNCHSNLYTNLENHHMLMLVNIYLYYNNNKNDDNKNDDNKNDDNKNDDNKNDDIPNLSFLIKCINFININERNIGTISETEIVMFLNFFKKYYQIKRKKKNTNNFESKLGANISRHDEEHDEEHDERDVFKFLNKKKERCDSENFELSIKKCMDQIVNKLIFAYATKDVGEQNGRLKDVGKRNESLRYSINLYFILYEIYFSHYIVTEKEKEVSLSFLTNMIKLNKNSLNAENYYHIISCFLSINIYDHNIYYLYEEYLKNNKKINKKYLLQIMKKIFENFVSISNVNKYKIKKNNNFIFDHINKNYIIQINKENYIFENIIYLSCNLLISDLDYIKNIRYFKEVFHIYCENYMNYYLIRNNFNYFSLSYFNKFVYSEEIKLNKNVMIILLNTFSNLYYTINKFLHAGKEGKMEKAEKVEKVEKAEKAEKVEKVEKAEKAEKVEKVEKAEKMNGAKAERTNACCWEDSRECVNNETKYNYFIKDELLKNIIKIIKNIYIDIKRKSNTNKKIGITDRELIDIIVALKNTKLRLYNILFFLSKIYINQMFYNKFTKVEHHVKYVNSIIYLDFINESNILYMSIIGKDEMEITKINQTSLIGKKNIFCHILFDNFLRLNLTALFVPNISTYILNILILYLDVTNRNSGGSSDSGGVSMSTVPLDALKLFYNKIILNNTDNLQTTPIHSSFVHHTIYRFLFNFFKEHSDKYKVVNEASIHFYNVDLCIEKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDR0</accession>
    <name>V7PDR0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_04438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDR0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01801">
        <property type="entry name" value="Ubl_TECR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB57574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="222" mass="26598" checksum="7B232126F6CCFF56" modified="2014-02-19" version="1">MKVILRKRNGKFIDYFDISPSTTVDQFKELFYKKYHYYPERQKWNLDNATGKTLVSGTLSEIGIKDGDILIFKDLGVQISWRLVYVIEYLGPILIFPFFYFCDKYIYSQNAKNKHIIQILSLWFLLFHFLKREFESLFVHRFSNATMPIVRVPINCGHYWILCGVNIGYYLFHPKYKPYNLGSKPHIVYSIFFVLLVLEFLNLKCHLILKNLRPRGKKYIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDR1</accession>
    <name>V7PDR1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDR1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="701" mass="84387" checksum="AF1BAF060CC5BA99" modified="2014-02-19" version="1">MINLIKLIDNKTNKLFACYPDIWKGYNSFMFFYILPLHYEEKNLTNTFLSILKNSENPDKNIYISLLLLNSNNFTTKIQTLKYIFYHYILINKNGAKNKIDDHVKDNFTIFLVENNSINVEKHMSVLFFSIISDLIKQDYITLIKERNKKKNETTLIHVKNKMETEQNDYISTLINYSLCKNIFHRYFNDLENNIINEDIKLNEKNINKNNILDIGKSEENGHKNNQIDILKNENIYYDMEKGKILIYEIKDHYNEDFLKGIFYYIKYMVEHFEEYILVSSPTKKKKIIPNSINKSYISCFLINCISILINICCFNKIFINDSYNLIINIKKKLLKHMNTSIVVSMVQFVLLFSTEDQFFKASNYLYILLSKEYKNYLIAITFFDFIIKNMNILKPKTFFFDKYASIILRIYFHHYRIFKNDLIYILPHLIYDNNYKDVFCYLLYIPLLITTENMESVSNIMYVNHENKKDTIYNHFKGEEEGFEKTSIQELDHINMYREIKNKIKIKEIVKNMNKYFRVYFKTILWSKKNEWLYQITKLVLYKLRCSEILEILNKDCIKELLKGLYNIIKNNYRLLLVLKNEFIILLKTKSNYYYLISRYILDIIAHNLESMKVTHDQIEDYYITLDSFFLKNDFSELKFWMSLIHAFTSIALYCHALSNHILITYENLIIQNKYPLILKYIIIENINLIKNISYTKSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDR2</accession>
    <name>V7PDR2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_05264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDR2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB56902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="134" mass="15695" checksum="1998421E7F357B04" modified="2014-02-19" version="1">MQILQFNFNFIKPSNNVSERGETKGENIQYVDKCVSSIIFDIINSNISIKDLPSYILLMTSKKNNIKNIFDKIIYDQDLSIIVKESGSYIYLNYLKTVIFTINENTNIKYLKRILKVLIDNDVCIEFDQRVRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDR5</accession>
    <name>V7PDR5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1943"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1950"/>
            <end position="1963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1963" mass="231999" checksum="9C8D1402E097199C" modified="2014-02-19" version="1">MNDSKEECPGQEDHNINRQKYLLNGNSYNSEMNPNNEYKESLINYNNFGNKNGIYIEGNENETNNNSNVANNSFYYHQINNINNENKNNISRDKTNFYGNNFDSNKNYMNNNADQNNNLYMCYENGSNQNVRKISSENSGSNHNRNEYNDNYHGKNENINFYNSSLYGGKVNFIKFQGNNDVRSDMNLQHGPMTNIMLLNGNENSDQKNCLNFINDISNEDRNGYKENNNFSYNINLKKKKNVTFNSENDVYNIPNREVATNNAYDNANNNGGSNDRSNDRSNGGSNDRSNDRSNDGSNGSASLSQGKIEYEKNETQNGGSINRNINNTELYNLVNLKKNNNAHNMNNIHNNYMEYDMNNNENKISQIDNNVNEGGHIKNDNLDKNNLLNLKNENKNNIYNNNMETYGNKKGKKENYNGNNFMQIKFNNTQNSNINNIDNASSSNISPFNKSDNCEEIIKKDGKNDGKNDGKNDGKNDGKNDGKNDGKNDGKNFGKNISEDDLKNHFVFKYLKNIDEIYETQKRNEKYDNNVISIKENETNNSIHTFIQASADEFDNYVNNYYNVLELLYNSSKKKKNINDKRVRALLYIFKYIKNTQRKKGKGKGKGKNDQIYLFDDTELKKLNKQVDLYMDFVKNREYKNDMFIQFEEKEKKEKSENKERGERGEKTDSVPDQAQYNISKEEMGKYIKNLLKKLLKNKSNLYYKPLKKTQTNINNFYFNHSLKKVDYLHNLLVYINFIILKYICIFSLAEWNALLFKDIINYNFQNYNDQNKLVKTKKDHHLEMPNGGSSVCVGPPPDESRDGDGDGTKNVTEHKVNDVTEHKVNDETEHKVNDETEHKVDNVTEPKVSDETEPKVDNVISGNVENDVNGINKNVINFEINEEIIEKLNPNYMNKENMIDINYYEHIIEPFDFFFYDQIYNEIYNYLEVIRNNNRLNNNDNLNYGFNLIKNLPFHYFQFIDILSKEILNIRNLIYRNKYIRYIFYYIYKNIENNNLLETINKVLLMEIKKVLLYKVQIKLRYNIFITRFFENNYNVINNNCIEEKEQNKINFIQAKKSLFNQLFNSYNNYYNMYMKERKQNYESRKIIFNITEEKFQDIRKKMDIYLNYLEYKKMEKETNIFKTFDNLDNNKFSDNKKMYNEELPQNEYERKKYNFDVSEKYIQFLYEKNYILIINSEKNNSRKLKVAYIVKDKLKENDNLVIITSILNINKWKNLFYAFKHISIYNNEENIIENKVSNPNGNLIICIDFVPKTLHIVCENIILDICHFNILNQINVLNDLRFLNFRKKIIILNDIPDNWNFILALFLLTIIPIDSSIANKFETAYFDEEDKKVLSSIMNRFISKFFIFYRQRPQLLTAANAENGENGESVSNAANVSNGANAGSSNNFRQCFLITYMSGIQKIIYDNVEGDNKGRACIHPLLLLDEELFNLKDFNISEKFDLLKNMIKKFSFLKKRILICYFGEDKLEKLIKMLLYLHSLNDISIIFARNINMIIETISNDTNNFDVVIIINEHMQILNNSQLMNNLKKKKVTLYFLISVFTKEEPDLTIEETHCTNNKELYFFKKNKNKLMNFEQNDADLVYNYYINNMISETDEQFLLFNIIDQKEQIYCNSSYNEMVVPTCFVSNLINSETNSHHSEYWQDIKNAHSFWNFNNFNKEKIAFYLDKKNALYNKYKNEVYYISENTIAPPQIYYYLNNPMNEKNTFNNCLSLALDEMIEELNRRRELIEFDELKKNTLISIKEKTNKKYFSSMRKVEKILSEFLNESKKKSFEEFLKGCKGYGQVLMKCKEKLFVTFNKSYNIHFKNFENLWLDEEKKRKEKWKELWQLNENNIANKDDPNNTNINNIFNNVNKETNEMTDNMINNNINKLKSDINSFEKKNFRIRLSSQLFDEKEFDKLFIERKKICMSTDDCQKDDKSFSCDVKKDADKKTCLYVERKNDNQEGDQQAQQGNENLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PE03</accession>
    <name>V7PE03_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Maestro/Maestro-like HEAT-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PE03"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314:SF0">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="1">
        <location>
            <begin position="126"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="510" mass="57963" checksum="8179E9ED8765B850" modified="2014-02-19" version="1">MSKVIHQIFDDYNRSRIQFTQSISDLCLKPHNIELLVNTDIINLLRPLILDKVPIVQQNATVILAKLASYSEEVALTILQNDVLPHLIYCLKHENKNYRKNCAYTLKCLANHNSKLANIVAEENCIDYLMDCLDEYDLRVKQSCINALCAIIKNDLELSNNVVDKGIIPLLILCLQEKDNNLIKSSLNMLSELCKHSDEIAKNVVDNNVLPNLIKFLDNNDNYIKKNACNCLSQIAKHKEELTELMIENDIFPKILYLLKDNDDIVKKNCANCLKEMSKHNEDICKIIVRAGALPLLCECIEQSSKDTIKLPAILCLGFISSFSESLSLNIILSNTIPILKKSMIEETEDYIKSACVWTVGNIGKHSTEHAKKLADENILIILVNLYNSNESSDDLKKKVKIALKGIIQKVTDLEALHPVFLKSPLKLAKYSIFQFSKILPKNPSYKKSFIKSGCLKYLQEIKNCEDSTKFELEISSINNSFPEDIINYYTPGYSETLIKKIDEVENTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PE16</accession>
    <name>V7PE16_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fam-a protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PE16"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004763963" description="Fam-a protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25674" checksum="8A839C13870D06C8" modified="2014-02-19" version="1">MNKAYIKNVYILLILFFCVNNKVFATETNSEGDPLTRSILHNPEESTVDLTNIIFNLFNTDSEAIDEQNKHLLCRNFGESENILSIMSQAVMFLHDHSNNINNENLYCKYCNDVNIFFKEVENVNIAKLNLKIQNCDKYDDIINILWDPNGAKYFDNNFIDGQVARIYHPNLLMIQKRYQQYNLLFQKYYYSLSIKVHVRNFFSFSPSQNHIFHMTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PE18</accession>
    <name>V7PE18_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">A/G-specific adenine glycosylase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_04498</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PE18"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="11">
        <location>
            <begin position="208"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB57659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="534" mass="62651" checksum="07716426127B80E0" modified="2014-02-19" version="1">MDHLESNSKLEKIAGQNGEPINLGNDKKGEKKKKKSEEKNGEKKRKINGEKRKGKDVAENEAYEYHYKLIKQNSCILKKSLLEWYHKYRRKLPWRNDQPPYTTNINIKNEINKDSDIRNYFLKTQDNTKLDDKGDKKKQNNIIQIKNNVNDNNNNIEKTQTLIFLDNKILKYEKFNKQIESIPKLINQNEEMEKLKLRGYQIYISEVMLQQTKVATVLNYYLKWMNKWPTIFDLTKSSLDDILTEWKGLGYYNRAKNLLECCKIVVNKYNGIFPNNLKLLKDLPGIGNYTAKAISIHLYNSKDICIDTNIIRIFSRITDTINYYGSTILSQHCEEVSKILCTDACNYSDFNQALMDLGSSICNTSPQCSICPLNKYCLIYLKENKKNIKNKRRKINGKINEKIKITLEIDQVFNLDHPNNCTLCVKDRTVDIKLVPLARSKKKTNKICLILIIKKSDNYKVNTKENQNKEQLDDYNYLMVKNTDSNLFLMHYLFPFILIENSTPEVYNMHLNSLLYKLNLNNTKSDSFIYVIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PE19</accession>
    <name>V7PE19_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_04501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PE19"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="197"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB57664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="393" mass="46521" checksum="E3C4CB1E9161CB78" modified="2014-02-19" version="1">MEEYKEDNSEECKQKYPNFYLADLFYTLQLSNLSLSERNEALLKLFEEIKKNNMYPYYSYVCGELNLDMDQEMYDTLKHKADEEMKEIENKIQEASENFDYVDTKNDMLLKANFYCKIGDKENSIKEYEEVYEKGIGIGVKLDILLTIIRISIFFNDINSTKKYLEKARAQMEKGGDWERKNKLKIYEALNYIMIRKFPEASKILIDAASTFTATEIISYESIIFYVIILGIMTEERTVLDKNILNSSVILQVTSSDEDLYNYIYSFYHCDYRTFMEKTIKIALRVKKDRYLGRHYRYFIRNTRVRAYKQFLEPFKSVTLKNMAYAFGVSEDFIEKEISSFIANGKLNCKIDKVNDSIESNQPNERNTVYQDTIKKGDILLNRIQKLSRVIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PE20</accession>
    <name>V7PE20_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PE20"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="129" mass="16002" checksum="AB63479189C31788" modified="2014-02-19" version="1">MHTYTNPENYIVFFKLTTWLYMHFETNVFFNYLFITFRKIFKNKLSKTNDLIIECEETSSQMSNYKICFDKLTKILEEAENYKEKVKYTNVKEFIHLIKTDDQIKKYKDKLINQKKKKREKKFNKRDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PE22</accession>
    <name>V7PE22_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fam-a protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PE22"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004763965" description="Fam-a protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30410" checksum="7F5E5FDC87D448AA" modified="2014-02-19" version="1">MNKGYIKTAFVLLSLIVYSSNRAIASESVPDVGNSNTVSKKNIASNENREKGNLQACIDPEETEKATEIMDKAIYRLKHHDYLNNGYNYYFLREIKGSICFTKYGDNDIARFYLRIRNQNNYNKIVKMLYEAKDLYSLGSNDSKGKVIREYYPNLIMLQRSNQTRNTPPNKYNFSLSAIAEISENITIIANTSINVNDDINVNNKKKKKKTTVKGAELSQNHIDFDNVARQIVLRNMFTDFFGFIIKRESDHVSITYVEYVSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PE38</accession>
    <name>V7PE38_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PE38"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="566" mass="67809" checksum="F9E312561BD6A034" modified="2014-02-19" version="1">MDIKEKIYELRKLLELQTFGKDESRENLLKLLRELYLIFMFHMTDDVGNFLKNIKDQVDSLLRLLLVHVDSENHTHNGEKILMINLIKLIDNKTNKLFACYPDIWKGYNSFMFFYILPLHYEEKNLTNTFLSILKNSENPDKNIYISLLLLNSNNFTTKIQTLKYIFYHYILINKNGAKNKIDDHVKDNFTIFLVENNSINVEKHMSVLFFSIISDLIKQDYITLIKERNKKKNETTLIHVKNKMETEQNDYISTLINYSLCKNIFHRYFNDLENNIINEDIKLNEKNINKNNILDIGKSEENGHKNNQIDILKNENIYYDMEKGKILIYEIKDHYNEDFLKGIFYYIKYMVEHFEEYILVSSPTKKKKIIPNSINKSYISCFLINCISILINICCFNKIFINDSYNLIINIKKKLLKHMNTSIVVSMVQFVLLFSTEDQFFKASNYLYILLSKEYKNYLIAITFFDFIIKNMNILKPKTFFFDKYASIILRIYFHHYRIFKNDLIYILPHLIYDNNYKDVFCYLLYIPLLITTENMESVSNIMYVNHENKKDTIYNHFKGEEEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFP7</accession>
    <name>V7PFP7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAMKK protein kinase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFP7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="329" mass="39034" checksum="91ED152981AD3969" modified="2014-02-19" version="1">MREILGNYENIIHLNKYKKGEDIFINDYKIVKTIHEGEFSKIIMCDKDGELYALKKYEKMFLEKKREFQKKTKDNKIVIKTKYDDLKNELKIITDIKNEYCLSCKEIITNNDEIYIVNKYMENESILKYDQCFFIFHPNESYFIPIPVIKCIVTNILKSLLYVHTKKNICHRDVKPSNILLDKNGIIKLNDFGDSEYMINKKIKGTRGTYKFMPPEFFVNTKCYYGEKVDIWSLGICIYALFYRVLPFSNKSGLINLFQEIANEEIKYHIDRNYFLSKVRKDATKKISHDSLSNEDINFLKIFLKKKPTERCTIKEALVSLSTKIQNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFQ7</accession>
    <name>V7PFQ7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFQ7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="243" mass="28822" checksum="7BF7B753E2FC4A60" modified="2014-02-19" version="1">MLNELLSIKKNPKDGIDMFLHNKCAIITTKLSHFIFYFLYNFRNFLNISPRSAIIIFLISYIIILYFFFMCWHSCYDYIKKIIHEDLIDDELDPSILNEIAPQIFFSICSLLLITLLYIGHLLAYMNLKNEDSISIPVSTLIIFFIVLGFCILYGIIFKYNNSASIFLIGANGIATLIFVIYKNRDIYFPSLICSGYYLYYHVKQLNKIKYIYYRKEEKYIKFRLWAYTIIFVSTLFVVIQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFQ9</accession>
    <name>V7PFQ9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein LTV1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFQ9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="65110" checksum="15433632B43A2B0B" modified="2014-02-19" version="1">MMKNKNKNKKVSFYEPSINKNAEENEKHEFSETLFENEDDNDINFYSNDISDEDMSYMLKKFNPLDFGIKDKLTESEKKIIIREIFGRTCPNNSSERKENDKNDKNDKSDKNDKNDKSDKNEEKNVKVKKVRNNIIVKDFSADDNVQNDTNHDKIDGDCYFPNDGYDYEQHLKPISNNFVEIKTKSENKSFEIKPTDEEEKELFKTFEADNYEELNDNFVYEAQNVETIEKLHIDSKLIWGNPESFLFISNNNLSSTQIGDENEDEDEEVISDFENDNYDISGKSIESTNTTVHDNNSTKYFQLDNDKELLCENTKNSKTITFDEKVNSSTKNKIKPEKNDDSIKLSDLINLELKKVDSTKNGITNGIANDNANDNANDNANDNANDNANEIKRIMKKNKKIKNKNKQNIENIVININDQDKEKILKIVDIQNDEIVVNSDSSSSYSSDDDSLSYDCQTILTTKTNTTNHPSKLIIPKDIKFTQIINKKMLNTNFETKEKPNDTVNKLERYLVLDQIKTKRDKNETPEEKRERKKSVKEAQRLNRKLKKENSLIMKVKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFR3</accession>
    <name>V7PFR3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34230">
        <property type="entry name" value="ASSEMBLY ABNORMAL PROTEIN 6, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34230:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="971"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1760"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1375"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1626"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1691"/>
            <end position="1703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1824" mass="212703" checksum="430E700BEDA2A907" modified="2014-02-19" version="1">MVFFYSIYSALMKYITNKLNYSRQQKIFVINNCLFFSFILFYISYYFFFNGLIYPAVKIVFHGSVIANQTIVYKNSILESIWLLYTSGSYFNMGVLLIFSVIIPVLKFIMVSDNFYSFFKLYNLSLNINENDKDDAKLIYYINIINENEEFALKKFSILSSISRFQFVDVFISLFIVSSLNLYLLEAKILIGAYHFLNYCILSTISSYLLLTFIKIKINIFKDGNIRIFSSRDENIANGKNTDTIIYNDNKELNNIYNNNNTKENHKWNKKNKKKKKNSKENFDGLNSENINNESENEDKIGNINHKYKIDGNENKSLEEDTSAGKTTGDEHMTSNKENECEEIDSIDCENIAEKNSYENNILCYNKLQSLNSVSYLYKIMKNNDAYIYLKKKKFNLLLKTSFQKTRYNTIKIAHAFVLLFLLCLSIYFITIVETDMLGIYIYLNFFNFNIESVMIDYIDMLNILELKVNRNYVFPFFFMFPFIFPLIIAISFILSVFFMNLYYVNFSIWYKKITELNDELVFDSEVPNNQKITISERHNYLCIKKEIEKNDKLSNTSDELSSHNNSTITSSKSEDINTEFVYNGLLNFYFLMSSFFASLCSILLHISLGEIISIAILIFYQIVKHTYNLNILVLYKTDKIHFSKFILFISFGLICFSINMYVAQWEKLIKKLQKIRKQIFLFESNRCSEIVDLNIQKNKNWNIPIYTYFFKFLIKQNQNIFKKKNKINISQDISNNNNHIIRTQTSTTYDCDANQNYQNCQNYQNCQNYQNCQNYQNCQNYQNCQNYQNYQNTQSSNDEEALNYLNSSSISNIKNKKNNNKKNKNPIEDTNGMLNKYNNQNKGDNDYLINSGMRKEQCGPVSFLFSEVKKRSTKLGKTHRIIIGQNYEQIKDGEDDNINDKNEHAQIEEGHNSLEKSNSQNIPYIKNLIPIKSILLIQLEKLKAKKKKDRGGGFGNKFGEKSEPINIANLFYYFHIILFILITISILMGFFKNEQVLRFNMNSVNKRLNDYFTSPNFYAFIPTSIGKCRTQKYLAKEPCYEVGRIYHEEKTFYHATLLFLQGISSVNIDNIYFYYDKGKYFLTFNGYFKHIIGPLFLKLCIGSNFCPISTYAYLIGNKPTFSITIEAKCDDNSAPNYISNLVVSDLKITKIEVIKHSDIIENVDIQLDDIQEKVQEKVNSMLAEHLEIIIWKNKKYDLESFINYLISRNSLFGFSYTSDANIFASSNDGIIGDDNSMNTFGMSENGSLYLNEEPSESFLENCNINSCVDIGQPNGNKINTQEDGSKINTQEDGSKINTQEDGSKINIQEDGNKINIQENGNNNSNADLKKKTEDVIDIVHTQREPLQTAEKEEIKNDVKLKENSTNLKKNKDADEMDDDMDDENLDTSVEDEYNDNEDEDDDFESDDDKEDDEKENQKQKQKQKEKHSEEQSEQNEEQNEEQNEEQNEEQNENQNEEQNEKLYKQIIIDNDKETEINGNKNTKENILGANPENKMEMSDEGSNPQLPKFRIHTEKNNIKIKNERNKIGNKYNIEFNNKNANQMGNTENRKMGNRISNRLDISNNKKISYEMQNIQNDNQHAGKFEDGKNLGGKKLGDKKLGDKKLGGKNGGVITSHVDKKNIENDVAEIDQENDEEDEKYEESEKDEESEKDEENEKDEEDVENEDDVENVENEEDVENVENKKMHGKNKTSFSNEIENINEPTKDEKNTNVSQKTILKEDNKCNNEENGNCSKTISEKIENTILQTNNIDQNLREIKERKGNTKPSLNISENYDPKPEQDYESNMFTIDKRMHNKLKNIDVILRGLNDKLNHHKDLKNVMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFR7</accession>
    <name>V7PFR7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Condensin complex subunit 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1441"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1443"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1497"/>
            <end position="1507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1507" mass="178319" checksum="D480A52E6892E13E" modified="2014-02-19" version="1">MHIERKKQMFRLFTLKGILKRFLLCAHYLNDKEIMKIKKMENDQSISEDIGVLKNIFMLLYESIDYLDISNLVNINSKNCIFELIKFYIELLKYPLIHSVHILCINYLIKIVIKCYDIRFEYNINVELYDIGPHVNIFVKIVNLIFAKILSILKDIKNSENVYYIEEINNINNLIALLFTNILNSCIRIIIPQVLYNDKQKQKYLLNNEMTRTTKINKIKDDELDAEDKIVLNACNPVFSFIEIFIINNSDKYEKTVFTDLIKIIINNCRKIEKKYNVMKIIHDEFMLHIKGEDNKKNGDKYLDKNYLKTKKISKKRLESTASFKISDECNSSVYSETEGEDEEEEEDEEKGREDGKSEMGDNQTNGYESEKETNKYCPVSKIKNKTKSTLEIDNKKYCIVYESVMIRYLNLLLKYMNCEKHQIRNMILDLFLILLKKKKTNKNENIYEKLFRLFLERLEDPNIVVKSKALSILVTLTNKKHHNNNLVRNFIYNKRKEKINMYKIISSNIFSHRSNIRKLTIQYIEVIFETLISQKLNYKIFLIFISNYLYSLSFDSILSVRRQVLLTVNILFLMASNDEYIGKLWITIILSAITDTEETIKDEAISIFINTFMKASINCSMFNTNEKKINQVLEENGMTYFKALTTFSHELKTKKDDYKNTKSDVEVNPIVKNGSITDSVTSDTNQRKYSNNIIKNKEGLEKEREECDKNNDGVILLIEIWEKYFESNMDNYFLTLLKMMTKYDLLNFNLILLCLTQKKNNVLEEFIKGINIFIYNLRYFSIRTWNTFIFDFIIELSKEYQNSINFESILFLLSRCYKIYLMNEKKNINKSNIIDKNIMAEKKIENIKENPEINNTIKTEFLFDSILTDQELANEKKSCPNGILKNIMLKLFTIISNLLNNENNEVNENFLEIIENTIFNFNCPMCFIYIILNILIKKKKNVNQFIDKLKNKIHFFFEKIEIIPYNNVFCNILVTFIFLINHYKKQDTEFLTMASEKLKIVYENVCKDKSAGSNETAIGGEDSDNLNHLGENIIMVKNCIYMAQCVLIIDKDMMNKSDFFLTLEKDLKNSNTCMNILNNLIILTYYMIKNFGSSCNKFVFNLLRFFKHENSFIRYLSFYMLSKLISEDYVKFNNQFFFGFLYLLADKNEIIRKQSLSVFKHIVLIYNKSNLINYMIDFIFVLNNFYSIKLSKHLIHIGNHFEIKNPEDRYKIYCLLIENLTNSEKFSFQQKLINEYLIQYVYDYDNYYFSDEHAKEKKGDDGINTRAKHNNIIPINDEGNEGSVLKDVLLILSSRLMKIKIKKDFAKLEEKNKNIKIKNVESSVKVLNDLMKNILKKNTLPILLSLRAIMLKTKSFFFKYINNLIIYLCIDYKDSLEELILEAHTRNEIFSDIQHFVYTDVIHSVHNNNDIFNKNSNINIDINFLELSQNQMIEHNLEKNMHNKNIRKKGNIHKKKNDDNSDDTSDNSDRSSDYEEVSNVLHSIHNRHQLSNNIKINKKTKKNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFS8</accession>
    <name>V7PFS8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFS8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="572"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1270" mass="146740" checksum="070DFD3325B09D7B" modified="2014-02-19" version="1">MEYIGNIYDKVLSGYVSAHVLKYKSWEEKLIGKEACKNDSDYIKQNLEEILGTFVKNGKFSHSLWEQHKMFIGDEGIYLLGEIITICQIVQFVDSDDIENVKSNDEFKTNLIDELKKRLIIKKKTEILEKKIISNISMCNGDNNFYNNYYDDDIDEDEGDNNSDYENDKNNIDSIASVSNSTKHDSNELDSNNNNNNTKLNDKNAVSNFVEMLCAGKANKYGFCEYDHKFNDKYNLKNIKNECKSSKSIEHSILSFSEDYDHKYVCLLLNNSGIQEVRILRFSKDCINTNKLLDTLKGTVTFLNELRHLFKYFRSQIFFKDKIYGEFCAYIKFHKNDPNFSGTKALNEFFNSLNDNAIKYLFFGLNEDNLNLLEEAISYCPIATFSFFKNIKLLKNMNVNSVRRTWKAVCSLQKLYKNYKKMQEQNFLDDIKYNSDEYNTTSIHQNISNNGRISLSQPPGNSKENKNELFSDYSNNNIEYNEKPFSGSNNCNNNMQNEGNFEMEKKNLRMTNNMLETNNSIEDNNKTLLEGSDKLLTESTYKPSHENKITRDNSMDDLRINMVKLFKTYGGQCRIGKVQGRCEDATFQTDTPPAFGIFDGVGSWSLEGIDASKFSIGLSLACQREAEKMSKNINGYENVSYNTIIRSKLLLKNSLESVKKEYADAYGSSTAIVGILDEYTGKCGISSLGDSVCMILRREFLPGDINFERETYPKFPVESFLYVNSKGRNPSIIRKIIWKTTDQKWENGAPYQLSNLPDRSQWKDLEARGLHSFVKILERVDIEGDSPDMAISPPSEILCMPGDLILLMSDGVCDNLFDEEIEAYCTLAISPEEACELGDPSAYTSAQDIAYSITNIAKRRSGDKLHSKPFLPYPGKYREPNKIYKGNKVDDISCVAIWVVCENEDSVKYIAMNPNEPSILETDKYYSNNYLHHFNKLTDMCTPTKSFIKEKNRIERVNLKHINTKKGETQSTFSNSNSTNMVNPFNASFFDSSETPIKFNDEPKNKNYEDLSDMVLRDADDEEMEENYPDSNDIEFEQIQSFNKKDSKKKQTLLPSQEEEEEQQQLLENDPLYSNTSMDDMIMKTPNNNMLKEKYKDQIFNQDDDFDHTPKQRMLEQNIDEHIDIINNIYIKTPLLHVDKTNKDNSKKNKSPNKCKIKNKIIEKKMMPLMCHETPKKQIQKNDEKENKSTIDENYYYDDDENDDLINKENENIVTNFEDSETQIKTQNSKNSMLKINKKIANTKRKYNFSPGKIDSVSKMNLYSKRSKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFT5</accession>
    <name>V7PFT5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFT5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="43227" checksum="58852C6E7218E28E" modified="2014-02-19" version="1">MENIKGQCNDNAETSASINKNLDIPLITKKKLNLRDLKCKNKDLSRKCAEIKQIFNEKENYFSFKEKGYNANKEKLIKEYKQAMKDNYDRQIILEEKIKNKENKIKLYDLQIKKFKLNIGDMHERIKKARYETLEREKSLSFLDQFKDNPSELVQLDMFDRLETIFSSRKFIKKKKEKLNAKINIIKEKIKELEEKNNLILINKETQYKKLQEESERIINNEKEIKEELKENINEHNKDALLLYKIISCIDNFLSRFSSFLPELRHYNIKKDDVNSEKKNKAQDIIEDPYFIDTVDFNNLEDEILKKLDLIYKYIKDTIYIINKAKKEIPLKDGNQIKAVEYNLNESIEFFTYNGNGKGKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFU2</accession>
    <name>V7PFU2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="2">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_03937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="2"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFU2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764033" description="hydroxymethylbilane synthase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="6">
        <location>
            <begin position="38"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="7">
        <location>
            <begin position="299"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB58304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="385" mass="44201" checksum="C0BB849EA074711D" modified="2014-02-19" version="1">MHILTFIILNIYITICVCIHARIKTENFININKSEFGKQKNKLAIKKNFYTHKNFKKKGKKKKIFLVQATKEIIIGDKILDKTVGSFGGKGIFTKELDEELIKNNVDICVHSLKDIPTVLPDNIHLSCFLKRDTINDAFLSIKYKNLRDINLSSHVIDKEIDLPRTIATSSLRRTSQIRYKYKNLKLKFIRGNINTRIAKLFNNSFDSIIIAFCGLERLVSKKILRQIMKNNIKDKSYIINYKNISIDLRHLNIQKLNTNIMCPALCQGIIGVTSNKNNPEISQILKNINNEKSQIMANIERAFLQKIDGSCTMPIGGYTKFSKNKIFFNAIINDINGLENYKIKVVRHLNDLDGIADEAAEKIKEKIGIDQFNKIKADAALYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFV5</accession>
    <name>V7PFV5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E2F-associated phosphoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFV5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019370">
        <property type="entry name" value="E2F-assoc_phosphoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967:SF0">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10238">
        <property type="entry name" value="Eapp_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="23407" checksum="61B193FB84EBC957" modified="2014-02-19" version="1">MCISSHLHMFLHFSLFYFFKENNDLHTSSKSKKKNNEQNEEHINSATNEEDFGDDVIGDNEKAALEFYDDKIDNYDEEYVNKKYRFCTQSEDSSLCCCGCFTPVCYQSQRHEYYVNQYRSLFAVNVKINKETILYENEINITKSDNKIQQNECQDIKKQNKEKSETYNPVFCVNCNNHIAYFEIENSIFHFFDVLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFV6</accession>
    <name>V7PFV6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_04044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF14">
        <property type="entry name" value="LD15323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1685"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="916"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1470"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="362"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1612"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1489"/>
            <end position="1498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB58446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1747" mass="206703" checksum="6ACE7F044224AB59" modified="2014-02-19" version="1">MCTETNDAISIENLLKQINYILFMSRNNTLRSAECDIINFLFYLKNNLKLNNDVKFFILNIFLHHLTYTKNSENLLNVPLMKFAFEVIYDNLKGKQINEILLKTASEIILRIADKKNEVFLEYLKIYNFKEICSIFNIINKKKEKEKKKKQKKKEKKTNTLKIDNISCNIYILISLLLLSSIHIPEIQDFFSVKYNNTNKGIQILGYMYESLNINIQIICCIILSLLIINKKIIDEDTINKTKMSILLIQNEIQNIKNVDYQLIEIICSKKNIIILNSILEYLLQNKEIEYNLILDSNECLEKYIINDDLFEKDLFYEKKIENADFRNNDIILQFILYIINIGINEFFLLKKNNKYIMKNKLLKMKIRRKEIEREKKLLKQRKKKLKNQKKENNIEKKEDMYTNWDIESVDKSGYENGRKNGKNGKNGKNGKNGKNSKHGKRGKEQYTSESTDSGQSDSSDYSASNNINRKNITTYNKDKDGVINNNNKSGFKNKLEEEEEEMKLSESSYISELYSFTSEYENANDSSVDQNKDGEDGHKKDGHKKDGHKKDGHNKDSHKKDNRNKDSHKKDNRDKDEEGNDDRDSPDKDSFCFGDLDEFKKIVYEDEFSIESASLKDDLEQFENFENFENFENGENDENSENGENFENGEQFESLSVDSEDEGKENKDRAYKIKEKIKLLKENRKKFARKIRRINEQIILILCNENMISNIYKCAYINNYKIKIYACIILCYIQNIRELITNKHLQNKYIQNKTNVKGNEKRILAITNIGDKFSEDEDTTYHNLYGVNNNIGKYQNNEIYNCGNIENRQNEEINITDNNSAHDPDYKQNYELGINEKVDASPPDSMIIKKNNKYFICSVEQDYYNYIYKFHIINTLLYYLFNDSCFYEHIFYGVKTFINSQSRIMNLNYFKIKNKKNKKKNKKKKKKKKKKKKKNIQNDTRNDMRNSSRQDQKSDSTSFYSSDENDKENNSITNISKTNKIKNVNKVGSISSLNSSYSDTEKQKCKNKYKKNSIEEDEGRYTTESAHLDNNDNEVGNEANINLSQNKIVPYTESKIYNHINNVFNYVENLKKLGYLNNIIVNLYMDISNKLKKINFEFLFKIIRNKFEEKRKTINNINKLKKKYEHVNIIYNDYIQLQYEYNKCMNIGDKLYDEFEEIEKKRKKLMKNHKIMHLNVSRYRKDLIQIEKTIEETPYIKNCLNEKLNKIKTNILMYKKDKKKLSLFLILHKIYLDNYNYVYTKLKNMDTFIENLELLGNEFEKNMNLIINEFTYLISNDLVLVNLLKDKLNIIINCEDISMLLKKEKFMYSIDYKICNENNLYIINKGTDLFENQDIYYLRNLPNNTNTSNNNNFINTKYVKNTNIDFADQNEAFSSYGDGHNYDEYKNLDNNISDNINLRTTTTNKWGAQSELVHNLDKDGHNDGHNDGHNVDHNDDHNDTGKNNTTSQYGEYYEQTGKDEVIGEIGEGIEDNENFHGNGNLDDVTILSDDDDDDDNNNEIKNKIDEFNNFKNIGTYGISPEDIKINNDKISQKQFYEILEILKRRRAHIEKITSPENNHIYKNIHKFNNFLNKCGQKIDMCKKLYSKITQKMSTMGTLSMAKKSESIYKFIREWDDKIEALNEEIKLVEAEKDNKEKEIAIQQKKIEKKENEKQEKKEELGMIVAEMYKHNNKLKKMYKRDEKIILLILYNSWFFYHYIYIIYLNTIKLKNYLSYKISIGEMCQASAKYTIMNINSFSELINEQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFV8</accession>
    <name>V7PFV8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFV8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="298" mass="35148" checksum="6441785381A1ABBB" modified="2014-02-19" version="1">MASFDILGLDENVNEFKSGENEKSGKNEKNEKNIVINDYRENIGNIFQYIIEMIKGKNKLRKLQLKLNLYCIKRFVDIINNTCLLIKVLNEIYIFSNKENIENVENIENWNNKGNAYKIIFLWLLFLYITSFFTFYFRTIFIINIVPNNYDNLFSLYKVFQTIKNIDSNNILILEFFEKFQKTYFIINKFFEDIPQFFLCLLFFILNGKDCFLIFTMICPFVFFTLGLLNYGLGLGGLLRSSLWASFHSIDDIFIKYDAAPPNMFFFLYSSIVFFGGSIVTIAVKNMVTSFWMACNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PG08</accession>
    <name>V7PG08_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PG08"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="581" mass="69684" checksum="3EE7C16C888901CE" modified="2014-02-19" version="1">MDIKEKIYELRKLLELQTFGKDESRENLLKLLRELYLIFMFHMTDDVGNFLKNIKDQVDSLLRLLLVHVDSENHTHNGEKILMINLIKLIDNKTNKLFACYPDIWKGYNSFMFFYILPLHYEEKNLTNTFLSILKNSENPDKNIYISLLLLNSNNFTTKIQTLKYIFYHYILINKNGAKNKIDDHVKDNFTIFLVENNSINVEKHMSVLFFSIISDLIKQDYITLIKERNKKKNETTLIHVKNKMETEQNDYISTLINYSLCKNIFHRYFNDLENNIINEDIKLNEKNINKNNILDIGKSEENGHKNNQIDILKNENIYYDMEKGKILIYEIKDHYNEDFLKGIFYYIKYMVEHFEEYILVSSPTKKKKIIPNSINKSYISCFLINCISILINICCFNKIFINDSYNLIINIKKKLLKHMNTSIVVSMVQFVLLFSTEDQFFKASNYLYILLSKEYKNYLIAITFFDFIIKNMNILKPKTFFFDKYASIILRIYFHHYRIFKNDLIYILPHLIYDNNYKDVFCYLLYIPLLITTENMESVSNIMYVNHENKKDTIYNHFKGEEEGFEKTSIQELDHINMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PG11</accession>
    <name>V7PG11_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PG11"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344:SF27">
        <property type="entry name" value="KELCH REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344">
        <property type="entry name" value="OS02G0202900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50631" checksum="4A4845E344AD6D80" modified="2014-02-19" version="1">MNVISKDHINISLMKRNCINDDRMDAVINNNDKNEINNNDIYPNLCFTNEITNEQILYNGKQDNINTADPDYSINNMNIVDTDYNINNINIVDPDYNINNTNIADTDYDINNTNIADTDYDINNINSDINNIPDCTGRDEENNSYTKKNTICNELNLEKSEELSDDINIVYSYVVNDSKRQMNSNNELISINITIDEDKKYVLRKKINKLPFFRYGHFLCLTKNGCILAIGGTDGKKKYALIEKYCQEKKKWKQINLMHFSRSNFCGICTGDNNLFVLGGEGNQHILKSVEYYDSKINSWRSLPPLNCVRHSASAIIFHNTIFIIGGKDGIGNYGKVHKSVEMLNLNEKNMKWKMCKSLKQARLALVAIVFDNKIYAIGGSTGVKDLKSVEIYDFKRNEWSEGPSLNFARSNFVAFPWKNHLVVYGGINNTNGVGLFILYNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>V7PG14</accession>
    <name>V7PG14_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_03992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000019">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="8">
        <location>
            <begin position="357"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="7">
        <location>
            <begin position="753"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1425"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1438"/>
            <end position="1450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB58379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1591" mass="185323" checksum="8F87C5623B52E86F" modified="2014-02-19" version="1">MMENNSSSSDSEGRCGKINIKRKTRDSYDSYYYNNSSNNSKNKNIYDRINSQPRKSQENYDIYDKIGKDNIGNANLINNKKTNNFFNSDAEQNEENNENSDKKRKIEIENNEPNKIVKTINSNNNFKDNIKQEEDVLTMNKNLSSLNKNIKNDNILKDLDGLDIRIEIDEEHKLDAVNLKNENLDKENEDSGDEKNNVNDSILKNKYEEIIINEDTGYVNIYVFDICKHKNSIILFGRTLTKLKRYKSISIYIEDMDRCYYFLLNKNKKYVKDGIEITYGHEKYKNFIMLDFVSEFKKIREYHNIKMAKYKIVFRKNLNLSSNNEELYAKVLYSYNYDNISEQFSKGDTYSSFYCCNDDIVENFIIKKNMKMPCWVKIKDLKNNFSNNIAYCYFDCTVASKKNIFTLDKFMEKKNTDLINGSNHNPTTNSTNSGIIHDESLKKIDNNNLNNFIDIDLNKLVIRVVSVLNEENNHEIFSICSLVDADGMKYINFFGICVKSNKKGSTPNISNNINDNKNEIYSYNRNNCKIFPNEKLLLQAFLNKIRTIDVDIYIGYNILNFDLEFLIHRCHVNNIDPGVLSRKKKLKKSDKMKVNKFSGTNSTGSIYNIVQNIKGRLILDIYALSKDTIKLTSYSMDEIIDGVRTKFQEKVKQQTGSNSVINGNNNSNNHTNKNKSRENIQNVFKDFIVNDINLINCNNIHLFDSEQILENHLNTYINSQIFSIYEIYNVCNVLQLVEKSRDLTKLSGYIWARSLLSYTSECVEYFLLHEYHKKKYITPLVAKKKTKIENDSNKSKNTAKYLGGLVLEPLCGYYDTYVLYLDFNSLYPSIIIEYNICFSTFNMKNYLALSGSTSEEIQEETGKRNIIDYNDSDVNNLDKDDQVGDISNIDYFDKTKPGILPSILKQLVEKRAFIKKLIASEKNKEKKELLLVQSLSIKLISNSIYGCLGNTHNRFYAKYIASYITQKGRNLLQHTKFKVEKEFNLKVVYGDTDSIMIDTGIKSSDVNNYKESLKLAHTIKNNINKNYKKLELDLECIFSKLLLLKKKKYACAKVIDPNLGKYEYEMKGINFIKRDFCKISKLIGNEMLRIIFSNKEYKPSQPNSSNTSLSHTDDLSIQNDLSEQIHEYLRSVYQRIQNDEFDLEHYVITKKLTKNVNEYQEKNSLGHVLVAERMIKDGYNVCVNKEIQYCVCRNEDALKFYNKGNEKLNSSLCCFSISEIKKYNLKIDKDYYIRNQILLPINRLCQYIEGTNIEKISSCFNIYNVKEIKSDEQIDESYLETNVLSLLSETEERFKNINLKGFLNCDNCHHDVKPVIFIKYFRCNKCFSLLPIDKIRNYIFSFINHLCSTFYKQMYICNSCLLKTRRIFLKESNNCPNLNCDNPKNSLKPILSKKYIYSILEYFLYLLKGNLLIIPTKLHQKGDVDAANEAGNDENKAENGANKAENGSNKGENENKTNTQINEEPEEYATDINVSVCIGDGYKIHILNNNQLIKNNKKNVFKIESYDNICKNKELNLNITKGLQMKFPNISNFITYLNLKNNTFCINYNEERNTIRESIQNIIQNDIYSQIFFDNIFSVFHLYVASKISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PG20</accession>
    <name>V7PG20_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-splicing ligase RtcB homolog</fullName>
            <ecNumber evidence="10">6.5.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">YYC_04729</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Catalytic component of the tRNA-splicing ligase complex.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PG20"/>
    <dbReference type="SMR" id="V7PG20"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1860.10:FF:000001">
        <property type="entry name" value="tRNA-splicing ligase RtcB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03144">
        <property type="entry name" value="RtcB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027513">
        <property type="entry name" value="RtcB_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="10 11">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="355"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="404"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="430"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETB57945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="507" mass="56240" checksum="ADC2F00B2FB0AAC2" modified="2014-02-19" version="1">MMKHGKGEDVFKYIEKTNEKNLYRINKGLVPGMNVEGNMYVNEKLKLLIDEEIKMYQLNKSSTFLPAVIQIANVSTLPGIVKASIALPDVHAGYGFSIGNVAAFDMNNEKAVISPGGVGFDINCGVRLIRTNLFYNDIKDKQEELAQLLFNHIPVGVGSQGFILCNQNNLDDALSLGMDWSVKEGYSWIEDKLNCEDNGRSLYANSDYVSVRAKKRGITQMGTLGAGNHYAEIQIVDEIYDKKSAKLMGIEKKNQVCIMIHSGSRGLGHQIATDALIEMEKVMSKYKINVIDKQLACTPIHSPEGQNYLKAMGAACNFAWINRSSMTFLARQAFSKVFNQSPDDLDMHVIYDVSHNIAKIEEHFINGKVQNLLVHRKGSTRAFPPFHPLVPLDYQYCGQPILIGGTMGTYSYVLTGTEKAMENTFGSTCHGAGRALSRNKSRNSLSYSDVLSNLKEKNISIRVASPKLIMEEAPESYKNVSEVVQTCHDSGISNKAFRLRPVAVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PG26</accession>
    <name>V7PG26_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fam-a protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PG26"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764030" description="Fam-a protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="49811" checksum="E1ED3BDFA1B0BAF6" modified="2014-02-19" version="1">MNNGYIKIFFFVLILFIYVNNNQVLTSDCVADNAASSPVAPFDIDSLETASFETASLETASLETVSLETSSFETTPRKTTRVKKTKSKRIPYKRIPSETSSSESLSEISRPKKPRSKKTRSKKTRSKTAQSEIDVSITASSEIDISKTAPSEIDISIIASSELDISKTEPSGIVLPISVLTNPPSPHIESIPVSFKLDKIYKKSKHLLCTNPEETKKATEVMEEAVELLKYYAITKNDYKYYCTSDEGVDIYHRSHGHKFYIGKCNFKISNPEKYDDIVEILWDPDGPKKFDDNHIKGKVARSYNQNLLMILKFYKNNMLSSPRYFHALAKKAQISENTTIIVMASGNINDNNLFNRKIYKNKLLKSMNSFETSIDLDDDIKNRYFKKTFVNLCGYMITKKPNHVNVTFINSVPNIQIEYHNNFVSPFILLYFFIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PG36</accession>
    <name>V7PG36_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PG36"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23525:SF1">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23525">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="47504" checksum="EC4D91FF73A2221B" modified="2014-02-19" version="1">MKKWMEEQKWHINIILMFFHHFFDRINYSMRNTFLHDHYIFLKFKKNKIIGLLSIINSSVCLVISPLIGYYCDKHKKNRLKILRFISISYLLVNIIHYMFIRTNNLNLIILITAISKMLQESSHVITESIFIESIEKGKKSIIFTYQKLISTVATMLGPFFCLILFYLYNDKWNITNIFIIFQFSILTILPQTIISFLWKNNTVNTLPKSEEISLIAKQNEKPNLLWLKSNHVPYIVFVSHIITLAGAGMTFKYFSLFLKSEYKVSPILMCVLNILIPLLLTFFTYLSQKLSKSLGRAQVSLFFTTIGFILLCSLLHIQNYQDVLKVHVFRSVFQNCTNSIDKSILYDFIDTNRHTGRWMGIQSLYYLVWSISAYFGGWLSDISSYRNTFKITSNNFDLNFILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PG66</accession>
    <name>V7PG66_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_04565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PG66"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001202">
        <property type="entry name" value="Translation elongation factor EF-1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="99"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB57747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="537" mass="60451" checksum="8811B38D805C904B" modified="2014-02-19" version="1">MNNEPFTFNANAPVYYPGTPYNVESQTEISEQNEISGQNEIISENINDGDSIADVENKISKMCLTPEKNEEIEVAKVEKEIQEDKGIDKKVSLVQVDSRPHLNIIFIGHVDAGKSTACGNILYILGYVDDRTIEKYEREAKEKNRESWFLAFIMDINEEERQKGKTVEVGRAHFETKDRRFTILDAPGHKNFIPNMISGAAQADIGVLIISARKGEFETGFERGGQTREHTLLAKTLGINQLIVAINKMDDPTCNWSESRYDEIQKKITPFIKSCGYNINKDVFFVPISGLSGQNLSEHISDKNSKLHDPRGSWYDISKPTLFQILNSLSPPPWDENGPLRIPLLEGYKDNGIVAVGKIESGTLYGSNMNCILMPNKVKVKVTNVYVEDDEVPYAKPGENVRVKLLGVEEDQISKGFVLCDSLSLCSVVSEFIGRVAIVELLEHKPIITAGYFCIFHAHTTCEEIQFIDMLEVIDKKSKKKKIKPKFIKNDCIVTAHFLLSNPVCIEVYDKLPQLGRFTLRDQGRTIAIGKILELKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PG76</accession>
    <name>V7PG76_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">YYC_04572</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000147">
        <property type="term" value="P:positive regulation of cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000766">
        <property type="entry name" value="CAMK/CDPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="929"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1041"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="245"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETB57757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1300" mass="156433" checksum="6187C12ACBE2B30B" modified="2014-02-19" version="1">MVLELLKSNYERNDEHYYNEKVENNTSKHKKKKKKKHILVEESEKDDRNLDSENNEEAYNTYELIKVRPNTIYEEKYDFSFQNLYKKGFREKNNMRESYRNSKDIIQYGTNENDIFTEDMFENDNFDDDSFVEDDTMDYKTYNSYTKPEFNLFSKYSTESIKKNIMNNKKDSKIEDFYKKYKNNSEYSKQANEHDANIIQFLNNNKKSVDYGKMKDINFKKNDSHNYSESNKYKNEFLKNYNYDNNYTNNYERDNNQDSNSYYYADENETKDNNEEDDDTGDTYDDNEEDEDNRDDNDDYSQYNQCEVESDTNQIRSNEKRYNESIKHINESNLKINKESLLKRETYNKRDNIFYIKKDIIPYKKEHNNNIFSLYDSSKNNNEHNNNYETKFVNYKHDGEKKDEQWLTNVKKERNEEFLKKYMYENALKKTYSSKDLQFNRLGDEKNILHHDINVDNKMFRLDKLERSNTQDIRNKTNKYNMFRHDTTELSKLRYKDEINDYSEYANKCLEGNIYDEDDSYILKRKELGHKELKVIDNPILNINHDDKKKTNIKSFLDKIKYRKNNELFLKNEHEKYADIQETNKKDKIKMKFADILHTKNFSNFFHRGKSSIAKSLSPNNNKKNANFNNEAFNLNILEKKDKNSDYKQYNIKCFPYDHENTSFHPSVREETKYYENKESRKRLDYNCDEDNYIENSIRRYNENNIDYNSINIEKTINLREDIKYNEFLNKPDKINSEKFSNNFSDNKQKSLKNDDSNKIRDTNKLYYHNNSDNALRSNYIKKESTEKIYDILESNSNNMRKFINKMDYYTKKYEQNLYKKDEDIYTKENNFPDSRQAFYNKSNSPMKVKDETKDSQYEDYNRIKYKLKMKQEKQDEEDETDINIDKKLSRKMIENNKLKEQNESNDELIVTPFYIKSKIDKVLKNSEIFERSARATFKQFDVKNKNFLHFSEIESLIQKLCYNLELPPVDKKILSIVYKDYDSSKNNCMNYMDFRQMYWDLLKQIKKKYYPTKNFKIKRNCIISRKKLQGYDYSSIYNYLSFKKILGCGAFGEVHLVEDNICKLYKVVKILKKKKMKNIKVNEEINVLIYLDHPNIIKIFDVYESVNCTYIVMELCEGGELMSKIKKPEIFSEIYIKNIMFQILCAIAYMHSNNIAHKDLKPENILFKTDGYDTLKIIDFGLAELINKSEGISKTAAGTVLYMAPEVFKKKFTIKCDIWSAGVIMYFLFTKSLPFTGNTYEEVKKNIFNNEPDYQSLKLKMSKPALHLLKLMLEKDYSKRPMAAVVIYSNFCFTWHILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHV2</accession>
    <name>V7PHV2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHV2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="45305" checksum="5509E6B702141C6A" modified="2014-02-19" version="1">MAKIKVRKKQKHAGTFEENLKNVVVSKNGILKKQKIKNKKLTKKVTEKHKKKNTLNKIIKLANITNENDYSDYDDDDLIDFINSQEDKFLEFNDDIEDEVIDDTNLYDDNEINLNQNYMNNNYEEPNDILEDLNIKINKNGYKGEGNILDNSNNKLTDFDKSPEQKTKIDTMVEKCYKVVGEHLAIYKKGKLHQALTILVKSPKWYELLLLTTPKKWTTQATFEVTKLFSSGLKEKDVCIYYKHILLPIILENIELNKKLDGFLYKALIKSLYKSKAWFKGLLYPVLLKDSTKKQIVIFGSVIQKMSISINIVTCCLNDIFKFQWNSHISYILTIFFNKKYAFSKEFIEKSINYFLTFENYPNPLTISWHKSLLTLIQNYRGMNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHW1</accession>
    <name>V7PHW1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_03992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHW1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000019">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="8">
        <location>
            <begin position="404"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="7">
        <location>
            <begin position="800"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB58382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1187" mass="138154" checksum="4501921A2E1A6BFC" modified="2014-02-19" version="1">MSNVFDKLRKQRSKECKATDFYEVKNKNDDIYEVVDEDGYIENKNSLKSFIVGDDKNYDSSDDVILETVDYSMITKKNAEKESKPKRNTQIDDFIREKKIQKIFSSGKLTKDDISKTRNIEKMMENNSSSSDSEGRCEQNEENNENSDKKRKIEIENNEPNKIVKTINSNNNFKDNIKQEEDVLTMNKNLSSLNKNIKNDNILKDLDGLDIRIEIDEEHKLDAVNLKNENLDKENEDSGDEKNNVNDSILKNKYEEIIINEDTGYVNIYVFDICKHKNSIILFGRTLTKLKRYKSISIYIEDMDRCYYFLLNKNKKYVKDGIEITYGHEKYKNFIMLDFVSEFKKIREYHNIKMAKYKIVFRKNLNLSSNNEELYAKVLYSYNYDNISEQFSKGDTYSSFYCCNDDIVENFIIKKNMKMPCWVKIKDLKNNFSNNIAYCYFDCTVASKKNIFTLDKFMEKKNTDLINGSNHNPTTNSTNSGIIHDESLKKIDNNNLNNFIDIDLNKLVIRVVSVLNEENNHEIFSICSLVDADGMKYINFFGICVKSNKKGSTPNISNNINDNKNEIYSYNRNNCKIFPNEKLLLQAFLNKIRTIDVDIYIGYNILNFDLEFLIHRCHVNNIDPGVLSRKKKLKKSDKMKVNKFSGTNSTGSIYNIVQNIKGRLILDIYALSKDTIKLTSYSMDEIIDGVRTKFQEKVKQQTGSNSVINGNNNSNNHTNKNKSRENIQNVFKDFIVNDINLINCNNIHLFDSEQILENHLNTYINSQIFSIYEIYNVCNVLQLVEKSRDLTKLSGYIWARSLLSYTSECVEYFLLHEYHKKKYITPLVAKKKTKIENDSNKSKNTAKYLGGLVLEPLCGYYDTYVLYLDFNSLYPSIIIEYNICFSTFNMKNYLALSGSTSEEIQEETGKRNIIDYNDSDVNNLDKDDQVGDISNIDYFDKTKPGILPSILKQLVEKRAFIKKLIASEKNKEKKELLLVQSLSIKLISNSIYGCLGNTHNRFYAKYIASYITQKGRNLLQHTKFKVEKEFNLKVVYGDTDSIMIDTGIKSSDVNNYKESLKLAHTIKNNINKNYKKLELDLECIFSKLLLLKKKKYACAKVIDPNLGKYEYEMKGINFIKRDFCKISKLIGNEMLRIIFSNKEYKPSQPNSSNTSLSHTDDLSIQNDLSEQIHEYLRSVYQRIQNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHZ3</accession>
    <name>V7PHZ3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHZ3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="240" mass="27849" checksum="C9FDF055EA8E7E58" modified="2014-02-19" version="1">MLMKDDDNDDENDTTQKKNKSGKDSNRIMKGDSMTREDLLQLLNEMLKLQTDMKNIVKILIQVAKDNNYDFMTVYNEAKKHNTIDPLGKYQIEMPEFDKVVESYHSDPEVKEAVSKLMTSQENYYSNISDSAILSVDKIIEIHHFMLNELYKIDPEFKKIPNTNELDPKLIALVIQSIISARVEDEFNLTSEDVEASIANQQYALTSNMEFARINIQMQTVMNKFMGDHFKFMCDREGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHZ5</accession>
    <name>V7PHZ5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHZ5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764073" description="Ribosomal protein L9 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18794" checksum="7332F06ED6E9D668" modified="2014-02-19" version="1">MHKLIVNICIHIYVLSCSIFKPLIGEIKKVKLSHAFNYIIPQKLGYRSTINELVDKEKNENTLRYIDEITKSFIWDYKKKLNDLIVPFEFEKNQNILVTQDNLLDYLLRRGIIRENDDMYQKIKSKKIKFSNFGVYPLKYTFLDNISINITVQIIESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHZ7</accession>
    <name>V7PHZ7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_04022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHZ7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB58417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="174" mass="20698" checksum="E8A667FDFD46412C" modified="2014-02-19" version="1">MKKNFTQEHVTEFLQNKNEETILRLAKELLLKYKFMEHTFVTRQMNTEKKIPELKDALKVVNALYKRKQMNETAPLEHYFPLEESLYAKGVIEKCDNILLWLGANVMVEFPFNEAIELLNQHLERAINLYEEMDKELIWLHEQISTTEINISRIHNYVEMKKGNKEKNAIETKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHZ8</accession>
    <name>V7PHZ8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_04731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the centrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHZ8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB57948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="129" mass="15332" checksum="07B51D187B84B70B" modified="2014-02-19" version="1">MMEFEKKIETETNEDIEKEIYECFSLFDTNKCGYIDIREFYFALKSLGLNFKKEKVKKLFLEIKNNLHDKLTFDEFFDIASKHINTRYNDEEANSMFSLFDPYDTGKITLASLKEVCKEIVGNVLIFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI62</accession>
    <name>V7PI62_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_03478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PI62"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764363" description="inorganic diphosphatase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB59241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="300" mass="35493" checksum="C3CA34314D2F06CE" modified="2014-02-19" version="1">MMNKLLLVHFLFFISKGLSYILKNRDMLMPFKIANFVKIGIQTATLSNIQKRKMSSAIINPDNRNLLNMDVKNEYNVKTNNELKVNLNFHNNNIISNMFSNLSLYESMNNFFQINNKHYMLKYNNQLNQTDFNISYFQNINDKYVQISPWHDIDLMNSDGTYNMIVEIPKYNYIKLEIKLTEKYNVIKQDTKKGKLRYYHNSIYWNYGALPRTYEYPKHIYRCKGSDDQQIFFTGDDDPLDVIDIGSNSLKMGQIAPVKVCHSDLCPFHSSSCLFILLCVCSFRYISSRFETDLRRLYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI69</accession>
    <name>V7PI69_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_04081</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PI69"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764127" description="J domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="64"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB58487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="328" mass="39299" checksum="929FAC740A4EEA89" modified="2014-02-19" version="1">MWPIAILLFGGGVLLAKKGMNYMKNQKVGLNKNFFFPSNLNKNLSNVFLKPDMKGFERTMSKSEAYKILNINPTTNRERIREVHKQLMLKNHPDNGEMKKLYSKNLSVEELDELIKNEEIKYEYLKKENEKIKEKNLKIQKKLLNYVECDNFTCENNKNYNLEKYNIILESIIDYINKLKAIDTYMKNDIYYLFDNFFYCIKEAILKQNSLCQLMKNDMSYFNVPEKSELFRKNLLTLRKINEHNSILRARIFLFNKFKEKNENLIHANFEQLELKYKNLKGKENILESKIQNLNNKIKKSTEVAKNQNMKKMKIYNNFNKTKIYVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI74</accession>
    <name>V7PI74_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1478" mass="175315" checksum="B5EF4B1971F082C6" modified="2014-02-19" version="1">MRDKTHDKVDGKYKFQKLSQKHIDQTFTVQSDSLTEPLCIVDNEKPQSLYDCSANIANQQTKVQYSNIDSHFQNGNNDEKDSKGDDMYDHNFSKYSQKKKMKKIKEKKERKKQRRKKEKIQNIKNILENDKKYYESYINSYISNNIPQSVDENKFFFSFLKLEIIEDDGIRVLKKNMLNNIIPFRFSVDARPEKGRKKVAFKYESLFTYKNNNLLGNCDNKNINNNNNQIGIHRNIKKIYDDTIDSNFNKTVKYIGIINDSDKYMIDYCKRKIMKRDKSLLCLDNRKLVAKICSKNKIPLLWIRVDNDFYIIGRIRRTQSVSMWIQQLLNDNNVLAQLESSFSLAFIPFFFLNKNITSNFNENKNNYFLGPEKSSTNINNNSVHYGDLVNNITSIGSVDSDENINHLDPDNILAHNTQKDNHTDVDANFLKFSATKIKNKQRKKNNLQNNNNSTDPANFPFNNITSNILAKSDQSFSMLNESYTIDNDQNRKFTINATNKNMINNFITSHQQPPQIDSNMIRISHISNKNEFENNIQNDLLKINKHYSQSSSSNMDSDSHDLNFTTSTIDDLNEDVNGLENCNYSSSSYKMKEKKNYKTHCKKNISISNMPINIEIIKALYKSIISEHLHYIVKIRCIYSLCFVHNKYIYTQKVIQNIFLEYFDQNFPKDLNQKKFMHAFFIALSLLRNKNNRTPKIILFLLIKKCSSFVLSINLHNNYNITKNTTYSEQDNTTSHKYISNNIGNDNYQYLGNNTTINNFTKFYSNPNQENVQINTTENVSQSNISLQTINNQFQNSKNYITKKKDEYNNVKTSIDYTNNEHWDYKKNIVQKISQITNNKKLCTCNKNIHKLCDFCKNDLNCSGKKKNLQYNQNKENQQKITYDPDLIIQKEEEEDIKMVLECIGNIKFKNQCLFGNQNNKFNGIGEYKTNSTTNINNISKSSSEYFFFQYFTKLTNNTNTMPTDTNYMKKRKKGKRKKMYHAYDFYDIDIYDGEKKIENHFLKLRKTKKEYTQELIDLLFLIYELKKLSPYLPISDTVITILLRSISRNKNILDLFRNKMYIENKYYFDMCAYLPNFIFQSKLLNFIDHKNANNFTIEIIRAILHLIMTGNIRVYKIYYKINESLRSGMDTIISSLKKNDNIMNNTVNDNNLLDNQTKKEISKDEANNFSKPYGKCEHTTFKDINNENEKNEKNEKNEKNEKNEKNENYFFVSTYTNFIERKVICMHLLNMYAAIQFISQIVKIFKNCEIEMLIWNIFYQLLLIFQQKYPFFFLPFSKLFNKYFKDYQKKNYTAFEFFYFLYGLNSINQYEKANKINDYNNITNFDDDNDKINIIPYLNNQYKIHTDNKLICDYALRNILFEETFTNYSSKIKEQNIIIYKYDIIGYIPLINILKFVSNTKKLKKNFIQITYIKYIVKYIHNYFRELIIDTSKFNENYFKNSILYDLKNIFVFLYGYGIPPCYSKTISPIYFPHYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI78</accession>
    <name>V7PI78_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PI78"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="372" mass="44485" checksum="DFBED043DCB8BB83" modified="2014-02-19" version="1">MKKQLKIRKTINTNCISLNKLLHNGIENSQIYFFYGNNAKMNKIILINLLYNFIYPFGNNNMSTHSVVYIYFSYIFDVTVIKNIISEKLNHEKKNPKQKSDFFNNFYILRIQNFNEIISFLLQLKKNYFTKNKSENDNRLNNITCIGIYNFTNIIKNLNISNQNYYFYLIHEFKIISKLLGISIIIFDYVQNEISDTSRGTNIYDNKKEEPQEINNTLTYNEDKIYKNINIDNEPYNKNTNYVSRKNKQYATTLQKNINNNQDYYSEQSSDLSSYNYYENEDQKYSEYELGNNIKIDDNNNNNIKDIEKSEPIKIPFSCSKHNKFDFIIEIKIVNKIRDRYIIRFTILKSRNNIKHSYSYCSIQKYVLTDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI82</accession>
    <name>V7PI82_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PI82"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723:SF6">
        <property type="entry name" value="GLYCINE-ZIPPER-CONTAINING OMPA-LIKE MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34723">
        <property type="entry name" value="PROTEIN CBG17025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1185" mass="135998" checksum="0E81A7BE766AE3C6" modified="2014-02-19" version="1">MIRNTGYDDNKIKRRENGNSNNPDSKELKELDELKDVDENDYIKGLSKIYFNNESGNYANHANHANYNRFSEGHFLKKYKNISRYNSDKRVGYKESDRDREHFIYSNNDRNCEDFENDSDHNYLNSEYKNKNKNKNKFYNHPHNNNEQNGQNEQTEQNNDYNKYIYHEYNNRGNDINENIQYDKNINRNIYRKNVLPQKCEKYEKYGQYERYDEPDHYVGAKIKHYNKNSPSINGNDCKDSYMYRDENGRGENGRGENGRGENGRDENGRYKKGSHIEYGGEKYGSGGDKIYFNRNSKEYYYINERENDSYRYERGNKNYDEYKNNYYKNYSNHNSKKMYNNMEYEYDENENENENMYERGTRGKRFDYDQNNNIEDGNYNQQFRTSLKSKECNDNMYRNNSYNNENDQNDPNEFYYHNRNSEMEHGNNLYKDNIHNYQYDDKIINENKRIDNNDDNICSDMEKGYRYSNDNKMKEEKQAPSFFNNSYNLNDKTQLNNENQQNGHPPNNISQQNGDVISTIPLPTAHLSTTPLPTTPLPTAPLSTTPLPTVPMSIPTIPTVGSVPLATIPVQGAVQGVVPGAVPGVVPSVVPGVVPSAIPSVVPNVVPSAIPSVVPSAVPSAVPSAVPGAVPSAVPSAVPGAVAMQGIPLSSQLPINSGLSIPGQIPINPTEIQSGDQQSQLSQVNPEQPVKRKRGRPKLKKTPDEVQQNENQNNITSYQMGNINNANNNLINDMKHPMYVTTCNNNNNTATTNNNNNNLNPVINTGYNNHLGHTITNHLTIPIEQQIQQAVLNQTQQAVINQTHSQLLNYQINNSGHPLSGQIPESIAHQLSQPIGPSLVHPLVSQIDQHTNNQINNNMNQQVSHPLIQPINHTMNMNVNQKYNHHMYGNSNISNPMNHGMYMLPNIVNNNSLNNNSLNNNNLNNNSFNHNNNYNMNEDQIGQMYNNSFDKENGNILDPNMYYRNLEQNKQNNDHNLCEEDRDENEFAKNNIKYARSTVSESDDKHSDKENKKIHKRRGRPRKSDVESQEDYKNGKNNFGDEYNNKTDRNNDNAQTESREESGYSTFVDENNKTISYRVAYHPADAVWEKISGVKFGPMILTSQSRTTNVILSKKRSIELGNILHNLIYGYIYKGDNVRLTIGKESKNVQSGSSFFLPSYNDCSIHNDDEMGSAKIFLCFVYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI98</accession>
    <name>V7PI98_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aur protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">YYC_03407</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1449"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1135"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1369"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="800"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1148"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1159"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1392"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1405"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="1573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1459"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="1478"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="1527"/>
            <end position="1529"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1607"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="1575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETB59144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1670" mass="194607" checksum="33A9604352657622" modified="2014-02-19" version="1">MNENIKSHNYLKEKNVLNKNPSNLVNDDILKFNTNIKRNNNVERFYHNKVSDSSNMYNKNGHHINKSVGAEKNISGNKTTNLVNIKNKNQRLFSKSENEKCAIRNINMREDNYTTNLIKGKDNDIINNRKNSNINNNEYLNLKSSDDKLTKNINISGYAYENILEDNCNNNGNDIRNDIEKDNNGNNNGYYSYNCKNLKKVKEPNNSLDSFYKRKRETEEENYDKKRINHSLNKDYYYNTYTKTDINDSHMNIKDIQIKDISENVSKIKNLENNIMNVKNMEKARSRVHNISESEKKMFNIINQSSNNSTKILNSHSFNTNESCNYDKYMKDIFNKNYDYKKIKNPENSYLETDENIISRSYKIEEEHINNSDDFIRRNFMYDNKLETKINETKSNKLEKNILTDIKSKNSNEYILKHKKNYNEDKGNNFCDNEFKQNKYDFISCSFNEEEEFMNDYINNTDFVKNKNEGLNKLIDINKNEEQNAAFTILNKENNINMETQEYNNSHENRKLLYNNVKDANEIEFNDSILNDFKMDVSKPIDTKNTISQYQEESNIIYKINNDNEDAKKDNWEYDLSSNNCKNQNDGLKTIGALNDIVNTYKRKLVDNTNNVLNKGQNKSDEDSENLLNKKRTESKKDNALDHKNRVNERNLISIASNKTNNNSNVSNVSNVSKVRNVNSGDISSTSSENKKNLIKKTKYNESISKRLFSTHTLSSNNKCLSSGNYLKNNIKPSIKNSFKETYKKDNLDRHKTIGFNRSNTNLDKINSNISQNNGITKNSIQKFPSSNIHTNLSNIQSKKKTIDNNYKNSTIENKNLEENNEKIKKRQKIEFNKTYNNSFLERMKKKNLNEHVDGNKNAFIQKTVQNRNNINFEKNKTKMFLSNNKSITNNGYNKNGLFSELAEKKEISKSTDKLTIDKKSDHSGHVEVGTKLEKGLGKEIEIGLQGEISINSKVEEKIEDPLYKQNNVGEVFRENVMDTNESNINYNSKSNTNKAKANALNRERINNNKEIRTLASSNSITKSGKNTLLVKRQNTNNYMRYGSKIKEIEDNKLKMKNLANNNKGIDNKYVPKWSSNKTSSSSNITNNIVDKKNNMLVKKDEINKKKKEVFNQVAKINTNINSVVENKQINLQTKKQHNKIINKDQNSTKSSNYNNKKCTPNSKINQSTHDTRKINENNTNRNCSKKKKNNNDNNNDNNKDIISKEMEKYKYLMKKSKIKSNSIPPGNQKEVEKNAKKYECRNNYRSRDDYDCNNKYGRLSKNEQINYDNMLFLKDKKGQLESDNEYPYTVQGVQNHSCYINNDDSKNDQVLEYLKEKDENISKNMNTSNSLNNGEEQKELSYFEWLAKEQEKKENEVDKKKKINKQDKLYHEKTENEGDEDNTLNKGVLNKHNDGANYDKMENNENEEDYDEEDSEEDKENDTNVMLQPLLAFNLKQNEKSYEQNDFIVDKHPIGNGRTGLVFKAIIRKENLQVALKVMAKDTILSLKIERQVLKEIIIQSSLKHINILDLIAYFEDKTRLFLVLEIANGGSIRNKMKLKHDTFKEEQVALYVYQIADALSYLHNFNIIHRDLKPDNILIHYSDSDVYNDEHASKIYKYGIIKIADFGFSCQLKNKRQKRSTFCGTVDYMPPEIINQIPYDCNADLWCLGIVIFELLVGFPPFTDNSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJY9</accession>
    <name>V7PJY9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plasmodium variant antigen protein Cir/Yir/Bir</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJY9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01590">
        <property type="entry name" value="yir-bir-cir_Pla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="32193" checksum="4128EDFEF660B0E6" modified="2014-02-19" version="1">MNYKLCGRFDTLRKYLPDELNISSSFDFHGLGNIRNYCPNGDSGGKECYMLTLKKDHKINNLKEFYEDHIKNNTYYINCDNNGEDCGKSLKEATEYANYKEIIDQKMDLLNINFEDIAKFYFAFKLLCEMYYVFAENTSNCKNCSKNVNQFVEKYNKINKDYNNTDSSPYRKILSTLSADYNRLKDKCQGVEDSHFPTLQTIEEKQPDVQRSGGNYRQSSEPISEVASSSSSIVSKLIPVLLIFGAIPIFWGISYKYSLFGFRKRSPKQHLREMVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJZ0</accession>
    <name>V7PJZ0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJZ0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="738" mass="87092" checksum="E739BA9B25E3C76D" modified="2014-02-19" version="1">MSCEVSSECEDLKTYHNEIKYLKKEQLKAYICKLKKEIKNYKNKELNYIIEIKYLRRKIIRLQNVIENDKVLKRDQFNYFLNHEKRGYSLKNYNNNMDIGFTENVIFTDNNFINKNRHHSFNRSATSLIYDNNDRNHKCGINDRCGSNGNSNMRRQSCGNKSFFKSDSIRSINQDIHKGKILIDKKDEDYEIYNGISKEIVGLKNEWKKIEKQNGNKKIIHTIKPIEKVYSCGEVFDNNKIINSKNYDDNMDKYRNNRREHSLYNLNLYKNPKNIGSEKGEKKEIFVSNRSYSSTSKFELKRHLISNNKNMSRMSSHINSIIEKDINKYNKSKENILYQKNEKTQSKNNFLNALTYENKHRSCSSIHSNLIMKKYKNIEKTNTIKINKNTFDTYNDAYHKKILSKKYTSPYAYQNSGKASSNKYSNKKSDIIRRNIKNVETKFGKYIPNEDQILENENLDKLDKKNEVRKNEVRKNEARKNVIYYPCIENGNQLVENDYMGIKRGTYNNLVKKYDSDNIKLEEDCDSSSSINKIKKYFQNEKKKKKKKKKKSEKKAGKNEEKKAGKKEEKKAGKNEEKKAEQNEEKANNNWGTTLKWKGRKASEKSETCFNDITKKETKSIEDDNNKNNRYLLNLKKVIQSDLKENFKEELEKLKKRNNMLISKPNVYCDIPFDSTSGGSDKDNYSKSSDDKKKNIGTKNRDKINISYLKGPTILNTSFNDIEKRISNLQNYLKKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PK98</accession>
    <name>V7PK98_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_03237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1408"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="407"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="757"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="803"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1128"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1200"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="827"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="867"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1075"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1205"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB59864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1448" mass="170852" checksum="560F3AE50B3665B2" modified="2014-02-19" version="1">MKRRQKNCIGLSNCSFDQFKKGVEFLRETDAILDDDIFIILKRVCSFFFFCFKNDDFEYLLKCFDKGNKEGSKSIINSNKSWTDNNSTCSKNNVLDLKNDEIYWDYKFSKGDFIIIKNINRLLLNKLVDNYVGYSWLCLIVSEYMNNLDMFTNNLCDNEKKEKEDEENEIWFKYQIYKNFKQIEELNQINKIEYNNIQNNPEKYKEEELNNRKTNYVNYLHCYYGNIFSSSCYDKKNRDSHSISNTNPNISNSYNDPINNNTDIFYLDDPNDRFNWIMSSDNDNDDELVKSNSKSEKKHLYNNYYKSSFYYEENKLENENLNNILYSNKMYNNAEKNKKRKLIGNKIYQNEQKEKAGNFEIYKNKNYSNEREVETGSYICSNENDEINEFSDGNPELGQSINFSENFVQPHQEYSEKKYSRKYKSEERIEKEDGVSDEDAESDGDARSDEDEGSEIYHSRNSDDSGNDHDDESLHYLYKALCDYLSTKYETNKLQKYMDEYRDTHSWKPPPFYWKILKNKYVAKEVLKLYEDRHLDPFLSCLYEDFVNRYYFELKGSNNNSSNSNGYGNNSNNSSGNNDSNSITTYTSNFNVFTLRISEEICKFLLLKEPEEEEEVLNICKNICISENSYIYTQLILEYIYRNNNDNSMRRLSQYLCLYIIYNDINIHNICNNYFHNVIENEVSISYLIFKINNLHNYTSLYNTFKNIYMTRNKGFMNINNTEIVNLHNNILQVLRIFNGNKLLLFDSTYLFDNNNNNNSGYKSGRKKPAINKSPNHNKDNDGSSEVYSHSVSVFDYNSNFSNKNRSNLEDENNRNRFGSGSEISGEEVASSEMSSSARMSGEISDSEVGKEEINDDERVSSVEMSGFTSQCGDENTECNGSSASKEKGSKMIADFSSWKNGNTTISSLVDSEELRFGRIEDINNNMIDEKINKDVPRLNKIKSDVSEFLLPSASQFGNRDYRHNKEFLRINIYAEKIPLIHLRDIFFLNNIINIYATNNELFNNNMYKIYGRVLIFLTTYSPYEYVYNHYYSSFFKGKKNSSKKYSTSYFNIYDDTISIIDEDENSETDEEGSASYNTESENTQITSNYDKGIKMSDEDDPDDDIIHSLGKDNYEIEKKSKRKFKEFSEIKNNQESKKHKLKNSDTKEDGKDVCADKEKEVRQTDKNNELVLKISNDNNSKIVNDDNISKKITIGNTYNQINDSTKEDNIKPRPNNEENVNDQKSPSENSVVKNSCINANDLFELRTEVMSCDEVKSHIFKNVKSKKKLKVNKMNKKKKHYFYKLFYKFRLTYNNFIKFVQTEIFHIYNIMHSNTYSDSTKDKLLLGKINSNLSASIIYKYVYNNIYKHINSNEVNLIYTKFIILKHIVDKYPQKRFLTLYFFKELYIFIIEKEKTLQEFSELRENIILFFVYMIRFENMFFYVINVIKKMVSFCPKLFIHKNVNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMB1</accession>
    <name>V7PMB1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMB1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="172" mass="19653" checksum="88B8EF0D20B3FD35" modified="2014-02-19" version="1">MFNYESIFINEDVVSEMTIDDVKNLKPYWNVQIANFKDSINEPVFTLLQMAILLNKKKIVGYLLARKSLDINVLSKHNQTALMIACEKKVPLDWIEAILKKGGDLGINVKDDFNETALDKCTFNSKAYQMLLKYGAIESKNSSEENNIMEKTSKKCDSIWSNVCGCGTRYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMB3</accession>
    <name>V7PMB3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IMP1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMB3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040785">
        <property type="entry name" value="IMP1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040955">
        <property type="entry name" value="IMP2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18591">
        <property type="entry name" value="IMP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18590">
        <property type="entry name" value="IMP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immune mapped protein 2 N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Immune Mapped Protein 1-like C-terminal" evidence="2">
        <location>
            <begin position="96"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17726" checksum="61322F887696BE82" modified="2014-02-19" version="1">MSDDKGAYLVFDNASNGSLFITWKKEKVENALLYIRPTKNVPEFKFAYNNGKYELIRNLQSDKKIFFSGICQFIKEARDIKGKVTLLPYLDNAFPIKVNIYFLKGNNVVQLKPGEAFDLEGVDALTVLPYGSSSLQVKTMTKDMFVGKGNSEGASISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMB6</accession>
    <name>V7PMB6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMB6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="135" mass="15323" checksum="7848E50454377895" modified="2014-02-19" version="1">MTIDDVKNLKPYWNVQIANFKDSINEPVFTLLQMAILLNKKKIVGYLLARKSLDINVLSKHNQTALMIACEKKVPLDWIEAILKKGGDLGINVKDDFNETALDKCTFNSKAYQMLLKYGAIESKNSSEENNIMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMC0</accession>
    <name>V7PMC0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1237"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1893" mass="224335" checksum="D0451F010F964FAD" modified="2014-02-19" version="1">MEIKLNIIFSEILVTITDEHEIEKHDKFFVDKQQKSFCVECINKLLFTKCPLYKKYLLFKNINDIYRIKNCHEFRYHFSFFLLDHTLFLSNTFRYLEEECKINENKNENNKDDYIYSVNNELITLATNACKEFLNICSDELCNIFKDAIYTCVLIRLKNYSMTKRKYFFILKLLKNLIQHVQIIHTTLKEESSVIGELMKLFIKNYSISNNINCTKDNTNRLLCNKINFEIQDGLENNTNNNTAIKLSSNLNNNCDSNLDTNRNNSYVNDKYHNMEHSLILQIIYELWCENSLWQLNKDLLKSFFINLIKNFKFTNKNTDLCNYYIEFIYLICNNYNDITYFFTEIIFDTKHLKKNKNNTITNICTSPDTNYDNGLDISISHKRSNLFNIDKGNTSDQSSIHSFSFLNAISDENCQTRINKKVQKSEQIMREKSKEDNENNYDVQNFSTNNEESDCGANTEMENCTDDHEENKFVFFHSKDSENKYDKKNLYQLYSNKRNDIVDYSFSEENNLGYYSQDEDIKEKETNFLKSNNGNTHDASSNCSMNKLDENYLIINKSLSYNSSGSNTNKNCDETKMSQYKKNKSNDNIYNHFNELHSIHHSINSSQSFLECQDEKKQKIKGSSLFQTYEVEKKRCEQKLDIKKIINNDALTNINDLEIRKMFDSSEYNTEKINCVTGDICHTTMFRNNNSNHEEKKDKKIKSFEDNKSKFLKTENSSTNFVEYNSDVESGICFNSNLLNKHKNKNTHTDKSHIDNRKDINSFENYNFENAKIGKNKKLYNKGSKDNKLNLSVLEKTDGIQIFIILCDNLQETLLNNFNRDIQMKCLEIFSNICSVDETVVNIIISNTSLVEWIFDFLSNTKYECLREKGLKFLVTFFFRNTLFSKTHAHYMLDVLINIILKYVNKNEDNYNNVYDSFSNNYSTFFFFLKTLNMLIDIANSSIKIFHIFKIINIISFLVDVPDFSAINIENIILLFEKYTLKNESKKGDSNNHFKLYDSCNHNSEEDKNVDNKKSISNSFRVGEKKIFNLDSNQKTIYNNRQDHNIPDKKYFENVSIKINKKNSLFLNRGQTFDNIETTNRKQDEKIKKEKEWNEIENNEKDSDNNIELDNIINKIYIAHILALFEVVKTALNIIKIVNINNPDIYIEFLDDRENKYLSELYLAIIKLLFSLIYILNKNETFLININVMDEKSKKATNIDNENEFQILTFIKLVLYFFTELHSLFRNIMKEKNNPFGNDILIFIKFLYLSSIFIFDNINQRKIFFNNISTNILFSSFFTPFFYFFSRILSHIHDIYEDFSIENRETQKINNLLPNNSATLVDDDQYMTNNMQKQSYGKMQEIINTFSLYKKRMRKVLVKNSPFTIFFQYVSTNCDDCECYRILEMLIYEDDKVKKEEKNKKDILMEIIKNNDFYFTNVLLFNFNDNERLIETVIYIFYLCLSYDKKFIEKKLNNSKINNYVENMFSSNDYNIDMNPLYLFMSLSYSYYFVTKEKILTVFRCIKKEMHKIDILMWLEIKQIKNIYFVFDCIFSLKINANNYNLYVGFIIYIIKLELSLYSSQQSDQIDNRLYMSISKNKDLVKKLLEDAEMENIQNNDIIYIYYLIIKLKKYSSEYCKNINIYKMMNTVIRYMNTISNKSEEINDIFSFFFIFFENLEVYTQKDIFNIIIVLQKLSFYVKNSLNSFFKKTEPSNDDHKNMNYDDNKNNNCKSNSCTNSIVDSDEAFILSSLKFENSFFYFILNLILYCRKYNQIKNINILSSSVPIIQLLIHAIQFTNNYFKSLAIFVLALLILPFPKIQKTNPPLLMILSTSFDKSFDDILLSSNKYETPHETIAKEKYIIRKCLFLPLVNSVDINIRVSSLSLLLSLLITSVIINRQKKLSIYLSVHLFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQF4</accession>
    <name>V7PQF4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_01939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQF4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB60987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="183" mass="22600" checksum="07F05DCB4E2F6A39" modified="2014-02-19" version="1">MNYHKILGVTRNACKKTIREAYLKKVKLYHPDLNKSPDATTKFKQIQEAYQALYNDNYSQKLYDNENIYNQRTNSENKKNNKNYNNYNEFNDFHRAFYEEYRRMTKQEKHDEYARYTNNNSRYSINDIFHKYPREFFYINLMFKLFPLFVVPVIFLFVVYKQYILKSYFKEKPILIYDSYGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQG6</accession>
    <name>V7PQG6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQG6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="51562" checksum="17CC98F2D3E5FBE7" modified="2014-02-19" version="1">MTLRKFKNSLGIIQNTIKCRHTKRYALFWGHNICSNNIDKNNLKIKVTETKNEINLLKMLTDQDVTQNSVTQNSVTQNSVTSNTIGSFQIVKKNNNFEFSRILYKPDNYEKLKEFIKVIEKNEKIINDYDIYYHEENLNNIKLNRNQEKNEIFINIEDILKDKKIASYEKKNYLEKKKINNLYYYNIQRYKENYDPSSFLIDKRRLTKSEYRYQYISAILPYICFAFMLFFPHFLICLYIPYIKEKNKKHREICKMIQIKQNIHLYKDIKTDQITNILDNNIKTIILFYNSKLFLNKYIKSLMIDLSKIFKNYSIPINIVGIDTSIQNIPYNVIKDINNNHFPLIYFILPYHYDNDSAVLKIENPFSLEHVIFQIKNFVYIPEAVVRQVKVCTTTKVEKVEKMEKMENIPANLLCLLRSFFIKCVHELGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQI6</accession>
    <name>V7PQI6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_01674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQI6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="139"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="8">
        <location>
            <begin position="280"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="9">
        <location>
            <begin position="505"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB61871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="858" mass="104229" checksum="CBCAFFE4FBC7D028" modified="2014-02-19" version="1">MDELGNVYDCDLLFNDNDEDDINLEKDENNCEDTTRLVNEENESYLKNIDFDIKNNMDKISTQYLFLYINTYKEKNIKNVKKLYNLKFYDIHLRKDEYPLLETKHNVIEYCIKELINKENEKNKFDTIQNNDNNTNYKDEEDKYYLLKIYETILKHFPYSFKIWYYYIKDSIEMVSDIYYNNKKEYEKINKIFEKCLLYLYNFKSIYIMYIQFLYIQRNVKKIREVFNKSLQNVCLNQHEDIWNYQLKFISKIDSKLINYEYIKRYVTIYPEQVIFLFNHYIKYKMHKQALSTFFYILNNDDINFDLGDKTKYDLYKEIFNLINSSKTLNNDVMEILRKNLDIFKNYENITSLYILLANNFVYEGRWNKAMDIYEEGISESYSINDFSVLFDNYIETLKILIDLKIRNHDGNNIVQLANKNDQEEETDEDENEMNISDDFIIDLYMDKINYLLDKRKIYIADIKLKNNKNNVYAWLNKIEIIDNENEKINIFNQCLKYFQDNDYIGKLSDVYITYAYYYYNNNNYKDSVNVFKKAIEDKNIKNLNEMANIFCSWIELEILEQNYNEALQIARSSIDFDKNNNFDKKGLQIVSYNSDRNSIRKDNTTYGFQNVQNKFNLKNSIKLVCLVLDMEINYGTVETALCMFDLLYHSKSITIKMVLSFANYLYEQKYFNECFKVYEKAISIFHYPYLYPIYVNYINKYIERYKDKNISYVRELFKQAIYGTDNKTYVPKEFSKYIFLMYISFEENYGFLKKSLSIYKEAIPFLEEQDKIKFYKVFISKISKSYGIHKAREAFEEAIQTLTDDQAREICLLYIDMEYKLNEYDRVRALYVYTAQFTNPLKFPKFFQVRLFTYHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSI3</accession>
    <name>V7PSI3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_01435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSI3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="10"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB61577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="287" mass="32641" checksum="3951421812F92F2E" modified="2014-02-19" version="1">MAIYILFSENYTIVSDGYGEKGIKKTFEDEFFICENLNVYNKSLHPNFNFSCFCLIDGHNGKNTANFLKKNLAQELSNSFTKIQETYDDTLPIPDHFIRIGVNSACKKIDENLSLEYPGCKDGATCVIILIKDDFAYITNIGDSFAYLCRYLNNAHRAIDLVDIHKPWVLSEKERIIKHGGTIENGRINDIIDVTRAFGDFPLKKYGLLCTGTFKKFKITSDDNFILLGTDGFFSFVDINHVTNEIVALSKKEERLVNVEKKKAVFDAKIICKNMVEHAIIDKKSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSJ7</accession>
    <name>V7PSJ7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-type ATPase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_00311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1078"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1175"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1332"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1367"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="4">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB62589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1442" mass="171799" checksum="0FFBAAEB2A84B6A8" modified="2014-02-19" version="1">MITSKYNDYKENYVCRNFLKTQKEKKEAKHFRFESKKTVEIKKYSKYFFLKSFLTRINEELYDYETRKNGKFSCYMMEHYKENCHEENCHEKNCHEENNGINSGNTNSAIIDDKKNKNLINGKTDDIETKYDINMCEDTSSSLCNFELNIGENIGKENELLNYIIFGNNIYRINRKNLLVGDIIYLSKGDMIPADGILIQCNNMIVDESNILKYNTKKYVNKISLNKYIYEMNKMREKNMDELENEINELEKGKKLSYFQILNSKIKTRFKKYSNFNNRKKKKNVYPRLEDTYNEDKESDYENNRETCFTEINGKINQINNSNEEYDDNKIKSFYSYFNIYEYSPLLLSESVVMEGNGIMIATCVSKNKQMFHNSIKRIEENTNLEIIINSYSKNVVILILFYCSLCILFIFIHFLINLIENNMQTYSYNLLMFLLNTVIIENLKYLLLSIDNMPLLLQNCIAINYKEIMDESYIIKSKNIFEKVLQTNTIFIDINKYINYKSVLFFFNTEYIVSFNNDLISHQMNFQNKIKSYTEFVENEQGHEICTHLFFSLLIQTVLATSNLYRYNEDSIDIDLSLLDCISSLKLNISYYYIKKNNILNIISNKNYYVMSFVFSDHSYMNKIDRPKMNKKKHYKEDKLQNKKNVLRIFIRGKPDVVLPKCSQYFDGQFFSKDIEKFREKVSQIEESKYDLTICFAYKEIIIGEKEKADLFSYKENNEYNFGNIEMNNNMNSTYLKYGEMDDFTCISIFVFEKTISNRFYVDYKIIESNNLHIKLFTKYDIEKIKKIFNNFPDFISKFKFYDSNSMYGININSNVNLKLGNNKINEKYNSNRHYVNTMETDNSKLENIYVDNKNETKDINITKNILNKENESERFNLKYSSYNSSLVHTFINNESMKEYSFFLNNNVFYNCSKNKLIDLLYISKSYRRTNCVVTNNNDYFIKNKELCNIRVCDIRSKDIVKNKSDIILLNRSLYDYIKLRYFSNSMLMNIKLFIEYNICLYICIVALSIISTLINGLEFLTTVQILYIYIIKNIIFHYISCSRKSNYCVGKKRCKNASYSYNVFSKDEISNLISSIVSKLIILIIIFLFGHLFIPEVSWNFVNSDVREFFEFSEFSFSNNQTKKRYYNTIRSCIRFKKNLENIKIANNINIKNDYRTIEEWEHHISPNRHTTIIFNIFFLFFFFSYIYIYIKTFLAEIDMYCEQIKTNKKENHKYLSLLKNKTLSKDINNMIKEFKFDEDNIKTTNEIQSLNGSQNCQKIYCGDDSCNYCDANNNEQNNINITEQYNDSTKNNDIDIQTSSLYSIKNYLKEKVSFIDTDKKKMLFDCLIGNYKTILAFIFLLLLHIIIIQYGSFVFNFHVKGLTLVQWGICFLFCLLDFLLCYIISVTNIFSISTNFIKSFQGLHEAPKRTMFDAMNDYKRSYISQRYKYDRKSTSQRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSK1</accession>
    <name>V7PSK1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_00312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSK1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF14">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB62594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="66465" checksum="DE1DBD2A8DD0DD8C" modified="2014-02-19" version="1">MEKELVVDSYIGFNGNISNNLILVKQEKCIEKKVYLEKLKSIENEEMLENAKKKKLKSVYNLKNIDINHNYYELKKEELKYNFFMIYGIGTNIIKEDIANNNRTIFKSDQNKITKLYIDKNQKYICCCKESKLMSTICIYDFENKNKPIILSLHKFKTEDISISNDGKYILSSGGEDDKQLILTEIKNQYFIYKTSSDFPYSNVSFFHKTNNFIIAKLNSIRICNYDFTKKLMSYEDINTSIYKRKFVCLELKENDEQAFFGTTTGDILVVNIKSKVLEKIIPEKYLFSNGINVVKSLDDQTILTGSGDGYVSLISVPERKIIKQTKLFGAINSIQMRNKSTLFISVCENIIYVMDMNTNNYNVLLLAHNNYIRDLCFPEKYNYIMYTCSSNNVMAWMFYDKKAIYLKNISKGKFIFYDKKFLSIPTDKYQKICKINKHNIEKMNNKLKNKNTSIDIGPPEKIIKDITCYNIKITKDGKYIALSMHNNIYLLTSKYMKIVAIIIIPHYDYCNVLMFYNGYDLITAGNNGDIKFWKFQNNKYVNINTINYHTSIINKIILYKDKYVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSK2</accession>
    <name>V7PSK2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2057"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1481"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2563"/>
            <end position="2636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1596"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2764"/>
            <end position="2791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2818"/>
            <end position="2854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="552"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="612"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1481"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1496"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1531"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2583"/>
            <end position="2614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2623"/>
            <end position="2636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB61103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="3082" mass="365044" checksum="54FAB8904D7A839F" modified="2014-02-19" version="1">MKTKINETTVDVENIEAEKDDVYSPKKPVYIKTYNIANIMEENYDFEKKNTINDHKNYENNQIDELNELSAFSNILEKEFVKNNLHNLRNINKNYHKNNNCNNVDDDAKLNEDKKGEEFGQSENMSDKHDMNKSGKHDMNKSLESDLSDSSIETDDDNNNNNFIPPNNELIIKILNCLTNLYKKKKEINKNDLPIYKKIIKFGVMWLFYIYKNIKTDEDNFLFNYSKYAEIKIYDILGCLLVLRRCALYPNLAKYIIHMQINSNLIQIDRTCPYILIYLIDILSIDGVYFLSSWKIKTSILKTIIALISNYYVMDLFCNYVDENNETLYTKLLSLSSNKKMKRYNIKRLLGIIMCRVKLYDEIHKFENSVMDIIIHREDYKNCLFNENIISKLIHEIKNIHKELYQHSCNPESKNSCYDIFYENEIFISEENEQNYNYYYTYKLHNYVLSYLEKSQFFNMFLYILKEFEKHIKNILFLNSYDISFITTLNDFIFYFLNCSGGINLLINYNIELYKKTYINICLIINKKMKQLNSNINNKNEEGEGADENDENGQNCQTGQNGQNGQNGQNGQNSQNCQNDNNENNYSQNDDTEKEREENEFNNNYDFDDPYNENNHNGMNENNQNGMNENINQIKNSGDSECIFPENNNLGFIQNKKDEDLNKEGFNNLDEKKEKKILYNEKNFFYDNLKCVYTYNDILRNKDISDIYYLNGYNYKDMKNTRNSCSYILCSIIAFYKSNLLINNFFKSEENISLEYLKIFSSLSAYPLFKLAMCNNRNILNLLTHLTHLLYYSIFLEKQYEENNSSNSQIIKFRKNKINDNNITEGDNNNSTNFFEDNNMNKSENNLISKNVKNKFYKKNSNEYILVTIKYILSIIYNLIFYDYSGYFIFHSGYSIFVCLEEIKNLIGEIKKKKDYYFGALNSKNINKFFLKDYISNDKILFKKYFIMYENLKGLYTDLYKYEKKKFSEMDIQKRKDTYRNAMLEFVQKCDKSNGEHAENGAYLNYSFIDKILSIYQENQFFNFLPLRSCYTPNVCKIIEALRIEKDKYILKKSKELNNYNCKLNNDIYISNSSKSCTKLGTTINDQYVELLEEFDDNIVSTICSNTTISELNTIYNTSSVIPNIETNSNSSLKIGYYPILPLNLLYYYMNKCPNISYFSDLYKTNHKNEHDENEHDGSEHDGSEHNEGIDKEDNKCDEENGSKFYQNKYGLFVYDNLIYNNYICIKNKKLDEKNKPIMIQTNNQFFNENDKNNDNYINKYDENNYKNIGSKIYLTNNLEFIIKLINKSIFFLNINNLKLALIHFNKLNGRNLFKIIKKRLKTLNFVKSILNVLFNFFYNLTAISKYQKIAMLKSYRNHELFYSLLYLLNKLLSFNDWLGSNNISEYNHHTSIYTLRYNIIYILRIFYLWYHNTLDNQSFLLRSVLRYTRILPCFNISGMLLLLIFFDFKNIFPEYIYSFYLSTNLKNICYENCASTTQHDDSQIDKQESDKTEISDSSFESETDSQYFQTFSNDNSESDGNLSTVMSQESGRKGGKNEDAHDDESNSSIDEVNKIKLDLVNNCGNLEHVKNINKENTQEFFNFSKMVNNNYTGIYSDVEADNEKSDSENENYNDEIKKKKFEEIILYSKIEDPYMISNISGNNIIENDRNINSNENRNNLDNINTEKKKKLIYMCCSINTTKRIINDQFLKKYRILNLNFGENEYENTFYFTNYHNRLTNNYLSFIGNLNINLTDLTDVDNKHNINIVNKEIEHSIVPPPPNTININKNIYNSLDNMMHKNYIGNNKSGISFLSHNKIDIKKKEKNKFENDNDIISNVKEKTTIQTTPYPIQNLLKDNEIDNVENIMNMLRNDEHIFEEHINIKYLKKDEKEKIFLIKKELKNREYINFEDICDYINFILRIGKSNNVISRCLSAYCCVIFINHRIPIFSILFKHIEDVISNLISITLCDKKDENNHNNTTILMNKISYFSFYSYNNTQSNNIYYTYNQELYILKELCNLLCFVLDILKICFFNNYKNSYNKLIKLLYLPSNKLLNIIQNLIIKLNNIFPQELIRFIVKIISTIFQGYIYVFFLYFTKNTIIHGHRNFPNTSMQCSRPMQCSRPMQCSRFVQCSRFVQDDTNSLFINKDILISEKQNLFLLTKKDKQCDETDDNQSTKLDTNFSEKKNEKNSNIKMEEYTQVFFSCPNYLKYIRFFFKFYFNIVNTKNVINDNNKDIIYKYSDYVNLKTVTMCLSTIYEIIKNKIIYFFIFFNVEKRLENIFFKYIKTSQNKNKNKNNIVSLFTNADNGFEKDPELYDKENYYIHYFNFFLKLNKHINISNLVEFLSFYFDIVQDNTNKNLYKIIELYEYLNIIEIILNIVIQIINYHFNSIFILIHLFQNNDQEAIKLLDHINKMYKICKIQNDTKQIYNKIDINKCRKKYFKSLSNFAKYIFYFKKHFLNSLLNSLRNLYQFVLTKSNPTNHNATTNSEPISNIEPDLLNSSNFTENIIDKDKNNSLIILANSILMIINKLQNVKRKVLNLDTSYIPSITLKNFFLFICYDLDQLHTLYKHQSLKRKTEFELDQNQNHQSVPLPKRRKLGLGEKNGEKNDENGEKNEKNEKNGEHGEHDEHDEHDEHDEHDEHDGHDEHGETRGAKRSYSFYFENMYNKTSFVINKDYLFNKLGEVFYSNYLINKIRKAYESHQHLDNNYLNTIKNINISNINPAVNKKIYDYPSHLFSDILSKIYLYENDEDKKSFILFNLPQENKSKEIDQTHSLYNYINVLKEELNKIEKKKNELLSQAKNKQYNKKNDKNIYDDHFRNRKTISSRAPSKHVDDYEAEKGNANQTINNENENDENKQITEQTELLSNNEISSEYIGTQNKNTGDLNLGKNDNTFTNYTNKTNANNANANNANNVNNVNSVNSVNNVNVNIFKNTNISSGIDMEGNVINNFNDDDNNLGKNQKKIQKKNINYLTKNNINNDDENIVINEIDQNYQHSNCNNNIDTTNTESNNKNISPDTNELINKSSQFEDCTCYKFTLLGWKEFSEDGHKHDLDVCKIVNKPVLLKDPRIKMKFLRILDRHNNIKDIFKKLGVDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSL5</accession>
    <name>V7PSL5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSL5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="193" mass="22326" checksum="118E39AA54DFF7E1" modified="2014-02-19" version="1">MMVELSNDEAISFLKQALHEAEKSLKVETKEMPIFCLLINEKKEIISSSYNCTNESKNGCRHCEIIAIDKYIYGKNYEKMKNKNLIKCFNNNTNSINKSLSNYFSELKNIDKEFEDNKENTNCTKEHSINFEQIQKEITKKIQKLKKFTIVVTCEPCIMCVYALKLVGIQDIYFCCLNERFGGCGSVLSLHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSN5</accession>
    <name>V7PSN5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSN5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="11"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1113" mass="129296" checksum="2C166E731CB69211" modified="2014-02-19" version="1">MDLVKYLDKNEQIRNICILAHVDHGKTTLVDNLISSNKIISEKNIGKVKYMDNREDEQKRQITMKSSSILLECTYNKNYVTEMFSNITISAEKNINENDETNMPTEKYANPQNEKTKNGDNPTSISQKENNEEKDKITNNSMDENMYLINIIDTPGHVDFSSEVSTCVRICDGALILIDCIEGLCSQTKIVLRQTWKEMVKCILVINKIDKLITNKNMDSMDAYEHINNIIENVNAYIYQLYMEQNMDNEDTNNTIELEKYTFSTLKGNVLLCSSIHCWCVDINIFTYLFCKKMNIDINNCNKIKKYMWNRYYFNIKEKKILKIPNDTNILPSSGGTNTVKKKKKNLFSLVVLDFLWRIYDITITNRDDEKIKKLCTELNISDQFLQNSKFKQNNNENNVFILTTIMSNFLSLSRSIFNACIEIFPSSKNISESRLFKIYPSLYNNPIYKNMLNCALDPSFTIIYISKNICANLQNNTIVGFKDFYGQNTFLSICKIYSGTLYENMILYVCGKNIQTRIKKIYICMGGDLLPIKQAYAGNIVAIYLSIENEHPYNFNNVPTDYNINNSTYENSDQKYGIKNEIIDKSECTTSYEYNKIKDGVKNSDIIYSQENENITDPNGQWDLQYLSNTVINLIKNKKNNKEHNIFLMNNNDGIFLNKNITLSNKKNVDSFILSYSDTCSTILHTIIEPKNIQDMNKFLRGLILLYTCDTSIDIDFNQRGEYILKFCGEIHMQKCLSDFVNIYSNIEIKTSDTNISIREGISDYNIKVKKKKNIVHDNMKQLHSYYEAVQKTIPSKQNEDNNITTENGKEKFKNLLNTDNTNINKGYGSPQNIHSNNNDDALISSTPFKHIHIEKDNTFLNTLFNYSNNIISTKLNNNSFYIFLSVLNMPENMIHFFDKHYSSIQTILENRGISSTFLNYSKNTFSGKNEDFMYKQCLMNLEKCINDIFFSDNFNCETFTGENEPPLDETKKAETEVHQNSYFENSEHKENNNGFVQNSKKTEPITKDNYQTNFLKKNKIYQLQLWDICVQNGSITLLCIKKYLNKKKDNNEYIYDNIITNEEYKNAINQRSLIDTYISENNSDINIYLNNLCLGFKLASKYGPIAQEPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUM0</accession>
    <name>V7PUM0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUM0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="384" mass="45318" checksum="7938B1AF27BA8605" modified="2014-02-19" version="1">MNEDILKALTNRELKKTILEKAQKVLSERKNIINEKNTNLLNDVETNDKDSIHCCNENYEESELGNKDIISLDDKNNLNPENKNIHFFNLQDFSMRYSKTCKINNLNYENIEYELLVSFMNTFNNKIKFHLKLNNNDMHEDKENSILHKMVKIFSDKLIICCTNPIIMFTQNNDNNSLFDKEIISQVSSFFNQIEECEDFENLFKNCLTTILEKIFNFKPNADDMATWVSRQAFVDLVKIIIEKSAKRNEQCIIYTANIIKKNYTNLGFFQVDNVVVLIEIIQYAIINLSEHKYNEKCISFVNEKWFESLQDLMISLKNCEWKIFLNQLIVIETFLCDKKRQNTQKTFNELHKQQVELSAIKNSSYSKWFKIELPLSMSLFKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUM6</accession>
    <name>V7PUM6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUM6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="327" mass="38900" checksum="E4955E9835DDEE8C" modified="2014-02-19" version="1">MIKYILKALTNRELKKTILEKAQKVLSERKNIINEKNTNLLNDVETNDKDSIHCCNENYEESELGNKDIISLDDKNNLNPENKNIHFFNLQDFSMRYSKTCKINNLNYENIEYELLVSFMNTFNNKIKFHLKLNNNDMHEDKENSILHKMVKIFSDKLIICCTNPIIMFTQNNDNNSLFDKEIISQVSSFFNQIEECEDFENLFKNCLTTILEKIFNFKPNADDMATWVSRQAFVDLVKIIIEKSAKRNEQCIIYTANIIKKNYTNLGFFQVDNVVVLIEIIQYAIINLSEHKYNEVCHYNIFIFTHIFSYFYSYFYFCVEMHFICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUN3</accession>
    <name>V7PUN3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUN3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052298">
        <property type="entry name" value="ZMYND10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244:SF7">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB63324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="360" mass="43466" checksum="DA3B8D136F5420C2" modified="2014-02-19" version="1">MDIKDIEFFEYVNNLKNIELLDMFSTKWFECHKNVVLINVYLHNNNELIDVVGDDKMSHILTKFEVLLRELITTYFIRFLNFEEKIKKNNKKTLQIDELKNKNIDTENSHNHIYDYISLYHEMAVLNIFELILLSDHIYEQIDTYIINLFAYIYSNLVSFLKTSSDEYFVKPITELPISEILKEENDKTHNIDRLKIYINVINTLRNIIDRIHLLNNTIVNKIVDYDILLILIPLIEKKPWKHDNYIFEQNEWIKNEDNAMATVEKQLWIILYTLILNSICQEKYEMTNYRRNNILKLRKYMNENLYEQLPPMKTLHTFIEHLYISKSVFPENKNSYLIIDVVIKFMNKNVCMVRYMCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUN6</accession>
    <name>V7PUN6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_00142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUN6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF16">
        <property type="entry name" value="RING_U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="317"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB63329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="374" mass="44118" checksum="FE512134FBFECD74" modified="2014-02-19" version="1">MSSTEDVLFQYFAKLLYLLIFSCIGCLLMIIIYYFKVPCKECDFMNRILVICILIKSIGHLNLSLIRIKRREEIENSEEFKYIIKKILRLFNLLTILLVTASLYLLHFYKNVCSKNTISMQIIRIYYYFTIALYFLPLLFYICLGLFLSIIICIMIYFSVDENDRIPTPKNVINKLKVVKYKDIDYVHKKNINQKKKKKKKFIKNSSLELIFDKVTKVIRNKGNTTKAKQNIQSSFENNIDNQKDDSNSCFSDIHLNEISKPLKQDTQNGYTKSDNNLDDMYSQDDQVKFTNEEILPDNDENINKFNKQTNENEDMCSICMVDYMENDNIMIMPCDKRHFFHSNCLSKWLNKSQVCPICRTNIVTCLNSKTDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUP1</accession>
    <name>V7PUP1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUP1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="7">
        <location>
            <begin position="439"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB63334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="69587" checksum="B655AD3D9B447C50" modified="2014-02-19" version="1">MKFAEKLKHLKVKSWDNKYVNYKFLKKIIKKKINPEIKALYDRIDKNDEQILEVCKLVNLDNTLLNQKDKKKKNEIENEEIDYTYLFFYVLQNYINMVKEHYESEYNYLYEKIDEIVFFLESDRVNLKDMESLKNKCLNIYNLFDILTNYLNINVLSVYKILKKKTKKERLSTSLDLYQKYCNNLHQISQEEHFNEKIKSTFLLIQKKIGDNCEKIDFLNFKIYLKSKIENLGQYRGTIFILCGILITLIINTIILLYLNINEININRILSILPIYRLIYVLNFFFLFIFGSFLFMQLYGVNFTYILDLNKKIVNEYYYLINYVIFLLFLTTVSLLIFLLDVLFNLNIFSNIILHVVILCILLVCTTIFPFNFYKYKENNFLFSSLSRVLMSGVFLVNSVNLLDNIMGDILTSLSKTFSDVQYIICFFLNGMDTTAPAKCPIIESYVNPIFVGLPFYLRFCQCLIRYNNERQTIHIYNMLKYVSGICIVICTSFNWGYLGLDIYTSKIILICAYVIGSTYMYIWDVYCDWGLLKEYNYLLRKNDNLMYPPQYYYFAGFFNLIFRLTWAITIMPINIFPNKVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUP3</accession>
    <name>V7PUP3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1814"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1923"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1425"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1823"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1923"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1948"/>
            <end position="1960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1974" mass="230701" checksum="CFEA088F3418EFE2" modified="2014-02-19" version="1">MISKFYFKTIFKNRNCTQKKKNSILKDSYNSYNSKYYDSQSSSKLVINENSNNVPKHLCHEKNRIKSPLSSNIHDNFYYSDNYFSEKPRKSEKKNNNNRTKQNNKACEVSLKNNNLITGKKNNITLAKNISKENINYKLTLDNDKLSVNYLKESHLHNNLKSFNQNFKPKKKRSIETQLTLGNTVTSSVCNNVDIKPFKYDDNNNNKDIVHDSYNSVNKLNYDGIVNTNNQINHVNKQLSTLNNFEKYDDSAFSRSNSLHYNKKCRTVSTENNDQSISKEGITIKNDHTEHRNLLNEDINLNKFDTTKKTCSQGKTVSNLSNGKEDNNNINKSDDNKTDPKCKKLSSPQVCMSNSCNISNYASDKFEDSYIINSQNSSNAYINGDNIDSEQMTPKAENILKKKFNDTNIEKNSQYNNDNTCKENYGTNEKKHINRYNTPINSSRHFSTISNNINNTPLEIYNEYDSNINNIKRNDSYITIGSDNLNDSVFNENQDSFYIPSSVYNNYGSSVVNNRYSVLSKYSNMQNKTSNGFSSPFINRSSNIVCKPRVENCNNNLLNEEDKKNNSMNLFPCQKSIDIKPINCEDKKNQEEIKTNNPKEQIESNVKISNTVKKEINFSELKNLRSSINSIASSNLRKTPTISNIENDNYSIPPKYIPEYIKSFCIFKDNHKKDEVSRITPLIDHVNSNNNDIGLITPKNKFDTSSLNKDIKMNNNDHEFSVDECLMKCLKEDPSKFRTNEDYERFCNEDKILNPSYVPHESRKLGENFLKNKKDNFSFINKNYNYEPNVNIAECGNSSFNYDGGFNDPHKNYFNNIKINVFNNDYVNNDNNCYNNNSIYNNHNINSINNLNYMKGGNDHYNNDIFIKYYEKYSIKNLDKNESEKLNYTDCYDFKDSSLTEISKDDSFCSDDLGNDDNDINCLKESLNSFDNLESTEKKYEQILKDFNGKIPLLHKVLKPLPVKNRSNNFDICLYLLQKHGGDLNNEENICILRDREIVQHSAIYDTKNNCIKSNITNVTNIKLYHPKWYNKKKIIERLKEQSCYNPFTIFGSAPSLLDFDEVFDKDVYNHFVSKNSRKNHSLLRILAKQKVISNLNDKISDKEWPQVHSYLKKRWSRETNIELNWACDPLLYEELEWYLSTNNEYLNMTDKVADIDVCYCPTLDPSSYYAWNDSRVIYTNLCYNKSKDDGEESNNDSKNMYSTNKSLEFKKNDKQLSFRKRASGCEHLMFQQNVMKQKKLSKKKKKLLKKKKKMIKEKYKTMDIDVNFGNYGNDNNREDGKIIKSAEGFSYPYKNMSNYHENKTDYINDQYMNDFKNNKENNSFYYSNNIISKNKKSIYNHKNCEDNIVPIMAVNTSLYRNNMDNKYNCHNTAFDYIKNKDNTIKFFASPKKKKKKSFKKSINSDCFDFINSSMTNSDSMHPTNNNNENSSHNIGNNNNDNGNPDFNCNDTTEFNEFNDFSTYNNNKNNFHIFEFNDSIKCNNMKDAYNKDMMLNEDNLKKKHNQKNYEQTGYIEEMCGNKNRQNDCELLDINENNFEKNNMHYFKSNTYMYDINNNNASGMKNYIAKSNDNIVYKSNYNMNQGDISQSFYKNNGKNNNYGNDNNVKMTMFRNMQMGQNEYNMNYHKGNNNDNNRNGDNCNYRKGDNQMSFIPRNFDDKNDINTYYKVYNASDNNSNHNFHKNIYGNKNIYVKSDSRYVSNDYNKLKGNELSKNEHISNNIGHFEYKSSNKNFPDQNILNQKDNINGLKEKYINMCKEEKQLITSSDHNQFNFFESNYENYNNNNDDNNERSNKIMNEYFHSKNPENYIQMEKKNKKKKQSNDTGNSNNTMENHQNNNKHINKNLRNIIPETNILKLTQENIDKKNIIENEIKNSNTLLYKKKNNNNNAGISTSSFNSKRLSNSNISANENKKIRRYVNKMHHDSDNVSIEHSENDKQRNTSKEIAETPSSATSETSMSSAFKMATSVFKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUP6</accession>
    <name>V7PUP6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_00144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUP6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB63339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="466" mass="55519" checksum="3ED4C029E4E751D2" modified="2014-02-19" version="1">MKFAEKLKHLKVKSWDNKYVNYKFLKKIIKKKINPEIKALYDRIDKNDEQILEVCKLVNLDNTLLNQKDKKKKNEIENEEIDYTYLFFYVLQNYINMVKEHYESEYNYLYEKIDEIVFFLESDRVNLKDMESLKNKCLNIYNLFDILTNYLNINVLSVYKILKKKTKKERLSTSLDLYQKYCNNLHQISQEEHFNEKIKSTFLLIQKKIGDNCEKIDFLNFKIYLKSKIENLGQYRGTIFILCGILITLIINTIILLYLNINEININRILSILPIYRLIYVLNFFFLFIFGSFLFMQLYGVNFTYILDLNKKIVNEYYYLINYVIFLLFLTTVSLLIFLLDVLFNLNIFSNIILHVVILCILLVCTTIFPFNFYKYKENNFLFSSLSRVLMSGVFLVNSVNLLDNIMGDILTSLSKTFSDVQYIICFFLNGMDTTAPAKCPIIESYVNPIFVGLPFYLRFCQCLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUQ0</accession>
    <name>V7PUQ0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUQ0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="80747" checksum="61E2491A4B1D5ED4" modified="2014-02-19" version="1">MILNNKLHKYSLIKTKTEDQYVYLENKIKEIQFLKNFELQYYLKIKNKKYSMKSEYEKEYSKENAIFLELNKSLLSEKIKSLKNFVISPYDKDVVEIILVPNKKNSENFGGYHRIFSNLFITKYISSYFYHIIEKKIEKHNLVKKTNNIHVRMKLKTDYPQAIKNIFRYIYDKNFRLQDLDFKLLITIYIECKNLKIDGIIDDAINAIREKTNFENIIKILEVWQIFKETEMVKDFSRILSDSWFLIFSEKYHYLLDAETFSHFISFDNIMINEMRIFIEAIKFIIKNNCNLEEQEIIFKNVRFGLLSHENLYNMHKYIKNSFDDIIHNKYDGTNFICMRYEDNKTRKKYDEEEINEKKDNDVDITTDEKKENDVDITTDKKKENDVDIITDEKNDSFNTSFSEEIKNLNEFYKIINMEAFEPPYIEKKNINISLKNVTKCINNIYSILFDNIFKKLLNKDEVKERYKPWNENQFFQCVNNSANENYSFQLIKKKNKVDKYSFTYGDERLINECRYCFKIIKSKNSNISIGIILKIEELNMTNHTNFKIPKVLIEGNEELVIYFDFFVNDFYICNINENDDSKLLNKTKLNIHAHENKLTDNDIINYNIAVINQILNIDIIILPKNITFKYSFPILKPITYLGEIIKMPFINIKPFFIFKDSLDSIIMPSIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUQ4</accession>
    <name>V7PUQ4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nucleoside-diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="8">
        <location>
            <begin position="13"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1140"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1154"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1173"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1183"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB63296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1612" mass="190543" checksum="C592FAC4E89265D0" modified="2014-02-19" version="1">MNYFFPPLDKTNLERNLIIIKPDVIEKNKISDVINDILNFNLLIVSVKREILTIEKAKRLYEDIVDKEYYSRLVDFMSSDKGIVCLIVEGINCINRCRILCGESLSKMNFEDIPTSCLKRKYGTNEIMNGVHLPDDCKIDKEINMFFSKSQFKNENVILVIKKSLGNPEKLTMLRMYLKNYGFKILEEKIVKNDKNVLKELEKEGINKIANWDKEKFMIIIILSRINCITCLFYLMGSKNVNESKIKRPNSIRSIFCINNDDIILVKNINNIKFLTKKFFNNGKYNDIITVEQINNFFFCKNFNFFKNRHDNIKLKNVFIECFRNLCQEKPNVNIANMWISQWIDKYMNLNFDNFDNSDNLDKNVKQHNDICYSNQHEGYRCEDIESKSEKNEKNEKKSEKKNKNFIIIPNINETNEVSEIKIIKYFEKLNYINLNLNELCNNEEKNNSLLGKKIEYTKKKYKNLTVELTKRVLKKTLEKNKLYNKFILTNFSHIIDISNLIKNEIISDSFCLLGNFANKVDLKKNLNKNNDYNDFFLFLKDKNINGIGQFECNSIGQEFLNKGKILIYRNIDNYYLEFKKKFKNNIIIFLGVKTKKLQNIINFLIDNYNYIFINHLSLSNGKTRCINKRGDEENHYDSTIGGIHYKQNYENNDDTDEYFLSETYSPDSSSLIYSNIIEKIIKLQNDNYKNMILCNPPINEKYINLVIKKTHSNIKYFYFDSKRDLQFKEVFTKGVGGKENLSNNYKSILSYEFYQNEIAKKLKDNPNFFKFDLNEKENDVTQNCNNYLYNIFDILKKKIILICNTTNIDVSFIGLYLQYKYPDIIFCDMNNMNKHDEVSYKNKNTRKDIDDVFDNLNYDNEEYQNKILINTIIDKMLYFTSQTNSNYFIFSEFPTNLKLIDLQKLSFFFEIKLCIFIGNDISYLSNFEFSKSFQTSFSSIFYYFKITDSLLILDLKDEKFKINNVRHIESDYVNIDEIKNDTCLIEKENKILEINEESKEKSNSVDSFLDANLINIKNETQINDNVKIKILMEIEKKIKPKLIIYNCPDTYDLKKYLKEKNNQNKNDKFKFIFYEDIFKDVHASIVENESDEYLKKLLKKKKEQIKIQVYIKYLEDKLGSSTNFLFSNIVLLDLQNEEAKEKEKEEEGETKEEETKEGEVKEVKEKEKEEEGEKEEGEMKEEEVKEEGGEMKEEETKEEEVEKEGGEVKEGELFKLAELKKIIHFIYFKKVEGYQKGEEINLPILNDYKIVKYQSSKNERDNITTEISKMDDDIKNDQVELELKLESSFNLISGIEYNEEEKEDENLSYKKEEKKLSLENSQVNDIIKNEEKFKTKKCSEEEEYNKKWKHKINSLLNKYPNIEHSCIYLNRNLPNNCDNIFCPKIIILFMPQNIHLQFYISFMICSVLKNFISINMENVYIEECVKGKIKNKIKRGRKGGRKNNGNCGNGKCGNGECGNGECGNGECGSGECGHIKNQWLGNNNGIQNSDDPIEIKTIFERVINKIKNTENNILLTGFPIIKNKYKISDYFYQFNFLKNYKIDGIISFYFNTSYFGNLNCDENISIDKYEDFTKFINKEFGYNHKLYFKTINDQNDITNALTNVYDMFQFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUQ6</accession>
    <name>V7PUQ6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 61 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038884">
        <property type="entry name" value="CFAP61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178:SF8">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="803"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1461" mass="175181" checksum="7074ACB72665D0CF" modified="2014-02-19" version="1">MQYDYENLKNNGEGDSINFVQLNKLINLYAHISFADISKVSKTFYDNFEKIEILYFNFNNDKTYKKIYENIKKKKEGIIGDDLSENNTKKMNIIKLNYDSSVKKTEREYKKVVNLSYYDIFLLLQNIYPDIFKTNEIILLFLFLDLYEIILVTESTIFDCVSFKTHLDELININKNYFIYKYKHIDWLSNLRDDDKNAYSLNLFVLNDKYYSNSKEILLKIEKICFKEVDYIIATNNERGYIPFILNYFNMIKKKKKANTLESLYILNKYTLFLPPITDYMKISDIEDVQNFLKNCDSDKKNEIIHTILSLKKYCKNKMDTEKTVYSSDAHIWELNFYQAQNYYIFVSRSGNSIINVTSGRILNNLDFYYKDKIYDFKNIIVQNENKNTKHFLMSFFSSIIIFKYYDKNVIHNILRLIKACSCHVEISDNRFRDVYKHFKILKKKDNKINIIKKKKICDNKKCMETYREEEKKKKKYLIITKQMCSKKSINIDNNLVFWGINDICLYTLYKILKNNEYIFNNIIIIIRYKNKYLCKNVIDKYNNITNVSLDRLTIYNNLKNMMVSDRIKIIYDNVYNIDRENKKLELSQKKWIHYDYLFLCFDKEDITTYSFDIDSYQIGKKKNFNFLELSNHSLDKNEKLDFLVKAKDYQKYENCESCKNCESCENCEGVKKYKKKKNENCRDNELEKEKEKEKEKEKEKYTTSESSDIYDEKIKPKNKTFQINENNEIGKTPKIKKINKGDNPEITIKNENEKEKDYYTDYYTDYYTNYYTNYSTPPSSCFDTSEESSSCVKDILNDGKQSANLKGNNEAKKGMKKETKKETKKETKNEMKKETKKETNKRSINGVFSISDPMLEKHFDEKSKYMKIVKNGVNYIVIYSNNLDILSIINFFLKNKIKTYKLIIICPYNCNKCDRENMKEMKKESVEKDNDKNDGGCIKDYIFKERGYYKNKEDLKNNYLFLNNTNLSNNYYHKNCVLKNIKYALNKIFFLFHLLKIRIIYGQIIAIKKNKDNKLKNIIVRFCKHKKTDQSLINQKNIIFKNFIILPCHILLSSYHFDMNNHLNYILRKSSIVYNQKICLNHNFQTNDKFIFSGGDLCAFSNKYRINKNRELNHEYYNSVEIGKMASKEILKIVLDKCRIPYNVLKLKKKNKQMENCEKKNKEMENCEKMKEKKIENCEKKNKQMENIQNKCDDIFYYYKKLKVFEKPFVYFNKLPCDFYFYYFQASNGDLCKYNDLLAPQSGEENIKPNINENNDNSRQFKQVYNNAFCTDTLKITIKNQPELNEKFNVKYFDISKNIHAQGYYCRITTNSLNMINSFTYLGREKLNFYNLSNLCNLSINYFYTIVKKVQTCNSLNYDILSMMNEEREQFIFYYKFQEYKNKLKEKIINTPHMKESIQLLIKDAYDKDVLKTYLEYKNSNVEDNDVCKNIKKHVQIHLIESIKKNRDLLNGYYMPTCNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUQ9</accession>
    <name>V7PUQ9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2701"/>
            <end position="2722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3346"/>
            <end position="3424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3477"/>
            <end position="3560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2709"/>
            <end position="2722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3390"/>
            <end position="3422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3477"/>
            <end position="3494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3497"/>
            <end position="3551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="3823" mass="456533" checksum="413913FA6352ED44" modified="2014-02-19" version="1">MSNNDQNEMNKAGLHYNVETGQNGYTPDGLLNNFNNYLNRENESEYPKLYLKDTENQNNVNNPKIKNKAFIDYGLYTHIIENIVDIDDNNLPYINNEYKSYINSKNIILIIDIYVYNLFFHFKYISKNINNYYLRFNKIAYPFHFSFHNNNTCENCTLKGNTNYGCKQKISKINEINKINKVDNDDNGDDGGNDVIGQTRNCDTPQKCCYNKKGTNKNEFLPKILCMWCERLKLAINIYNDNKIKYMKKKTENSEQDIFIYNQNSRYSINECIKKLEKITFYSKNYDAFKNIYFISSDKKYIYSIYNNVLISNTNKSTKLKEKNNPDLIQDSFDEIKTTWEKKSDKKNDKKNDKKNDKKNDKKTNLLSKENDIYDSELYNSNVTDLYLINLVKCKIEEYFKNVQITKFWDIINVRNLIEFDYKQINKKMDNNVNSRNYNESIYEYIQIIKKTKCKKDVKTNEMTKNCYKIKRNTSHSNNNNVNTTSDQVFEKKKLEKEYIIKDMFNNTMKDYNVNEIEIYLSNYDNIFFKTITSFYLLLNFSVEIMSILYENLDLYSYHIFSLYEKINKYLYNDQNNIETNKFELYQKKNKHVDSDQNHNKKINWYKRYGINNNRKNDKIYTNCNSPNVHKNNKKYNFIIKVNNYFNNLSHKDIKLDSAVFVLLKLFIENKCDEEKRQCRSMDDNTKYESIYKSLKIEKYKEILKEIKILINYLINKNILKGKHNLNYIINVYNKYDKKIKELKNSKYVNNKYVNNKYVEILKKNFLLYSLNFYEFELFSNKYIDNYLNTLDKSISSKKIKLKIPSRVYITKTLNKYVVFRKKIVYLNKKLYENSFFNQHVIDDNYIINSNGDKSKQVVIKITMKRIKRKERRFYLRKLTNKVYTKFKVAHNIYTSFKDEDETKKHSYHNEEDTNLFTEYQQNGLLKKLNLIKLKLKIGNIIKRKNKVYKKVIKKIKERKKTIKKRRLKNSEIYYNKFVDLFKNLKNQDITIRNNLYNMISNINEYINIFYSNISHYSHSDIFENKDVEHFMNQKLDKLKDDIHLYFPHDNNFDSQHLANLNNEENENYRSRNRNSNCINCSDIFTDVCEKNVTNNSENKLSNTNNCSSLLFLNTNKNVKKNSFKKIEKIEVPFSHLFNNTKSQACIKCHSKLDTNILRKKKKIIYNLFNLQNYYKKKKRKINYLAYDINILKEYLYIYLKKYFDDIIVLFEYFYFYFSNNTINVEYNDENANKNSKDTNFFGKITNSKCDEKNRHDVRIYNEENIYNKKSIEKEINNQDNEQNEDLIYRYFFLCSYDNFSNGNDGLDNIIIKDKNKYSKYYINYILTKKLKLFIKNDLIQFINRNINLINNNIHLKIISVKRLFSKVLNNFKLSNSSNNLFIYQILYSMIIKYAKYNKNKIIKKNIMNKLSTWEWNQDVNCDIEKNISFLKKKKKYLQKFGLNLASLSNDVIMFLKYITTFDSPKSDYSNVDKNGEKNGEKKKGYVNCQIENTANSFYIDNDEELKKNNISNLSLNSIFYNLSSCRDMIYLKNVFHKMIKKKINNTITETPTESIAKWNKNKCKHVNKTKDDEEDFEQFSHIYEIIKQKSLKKYDNLKLFITIDKKKKTRKRKLDYDESLMTNNFYNDNTNVMIKKIKKYIIRFIDDNKYVFPYIFNTFDNSTNYELNSYDIINLNNNFIFFHYINNTSKWSYKNSILNYIYGYPILNVYTKSEDVQNCYIKDISNNNNNIHFGQQKNGADKYEAYQECCNKKNGDDKYEAYQECYSKKNDDTHIERLQKIWKKNKRRKLINIFNNVKIFNKIPLKYIHLCVISDIFRYLNLHHIIQDIIKNLYIEKLKEIQEYFLFSKKNNNNLSNILICFLFYFYSYLDVILGIRDGNFINLTNLNYFNIFNNFNDILLKKYSQKKDGNNVYVKEENRDKNKNKENYCEDSFNEDVKENYIYLNNELSHRNNYLWILKRKEKNVLSIPCVDAIYLKLRNCKKVKNNFQTFSTNFVQFLNLYLDYSYSFLNSSKYADENKSQLYLFAQNEDTEILEKAGANNAASNCDDGTSNCGGISFENLLRSKTYNGCKIYDEENESPKTNMSINNFFKNVKYKNVLCNYSNISINDVESDFENYNSFLFLSKINLTNSMRYCEKDICCLKDYELIKKDVEKNKNFIYSESTNILDNICSNNLVVRIKLILDILRIQLNKILEKKKECIINTLTSCKVNKNGLENIKFAYYLINLLDFEQKKTNISDIYIYKNIYYSLIEKLFTKNNKISCEQVIYIIFNLVKITRIIKIKNKQIQKLFKLLQKYLQNFPDFFSQIFNKIFLFIYQDTKFENKQFLKKYLNVYFNDKRIILDILNHIANSARNKKARSLDKGKDKKCSKNHIHETFANSSTFYDKKNETVHDGKRQKESKNVNNCNGDCSGGGNGRGVHCEDGYNHTFDKHDEKNSKMNSKNDMLNKWVNDFPLSYVQHNNNRKKKKNLKKKNFSHFNYEIIKKVFLKCKNIYSSDSNSSNNGNIFKIKNIKNQNYKQYEEEKKKYIYQKIKKNKISLTISKDKYEDDNNFTLSNGMQLKCKQNINNKKNDENEKNMLKNKKFEDSSSDSYINNIYIQYNQNEKIDKYINISNINNYEFLCYNKCHDRYENTDSSSNKYTSSSCYSTNSSNNKDQIIFDMNYINVDNSGKLLSRLSTIDLKGIKQNEEIKYYKTNKCNNKKNDNNNSSSSSSGSGSNGTIFNDNKKNDYFYNFLNSNKKDNSFCFIKYKSYHEFNNKKRRKINKYKKNEKKKNTPVMYMPLYISIVGGLDFFLYKYYNDICETYINPYFYINTYYFEKYIRKKYKNLKNEDNYLIYDFYYYNYIFLNKFTTFDTFNSIKDKKVETNKYIKFFNFKIDAKQPQNVICMEDGQYPCINNSSNNDNANNNGNDNGNNKQCNHSIPIYYNVENERKNEINNFIIPENGNMSTMMLVDMKKSVDEKNTNIVNVPRNIKNNNDKYMKQYNGNKNDSIEIYPNLKQINNIFKLVDYNFFYTENSLSSDDEEDRIRKKNINDIQIFKRNLFIIEYFENYFNFSLLTQMRNILLDMFENYNLNLGYINKYILINEKNDQIKDPYSDINIMSPNFSNTKSKPYKNGSPKWNFVKLNNSPLDRNKEVSKSKEVSKSKEVNNGGSGDSLDIVEDMDSSFYNNVLKTFFYDMPIQISMTILNPEYWKFEGLKEDQTINHIIPECVHKYLNIINNIYQKYNVDKYLIFLYDLCYIDLNINDYMYTFKLPDGLFFLFLSNLENNAIDIYKNSLFLKNTKKENTNEKKYNNIKYNYDYIFISSNYKHKENKTLHIIINDNIILYDFHIIQNHQTFNAPTKKKRDKLQTGQEWETTEGAETIEPTFISSQTKTATKECQLVKLEDGKNGEKNGEKNEKNEEKNEKNGEKNEKNGETLLSVTESNFLKKTKIIEIKDLEKDRKEEYSMPSGEQNKNDAFVDKVKIEKASKSFSSNGEAAKCDNNSITNERCSERNGERNGERNGERNGERNGERNGERNGERNGERNGERNGERNGERCSERNKAGGLKNKNTINKQISRENIYYNLKFIKEFQEKEIEKIKNIQNINDVYIKMFFTEEHIIQNTEFSEKYVKEMIKKLTCDKFLQKNTFKVINKQNNKTTQFTVYCIIDFDTNLDENKIKNMLNQDQKSIKLETQLQTWGNNPFNNQIQTKDNDVYPHDITQDEPVDYFLDDVATDDDEEKEIKRRKTFDNLNLEGSYEFYESEILKITKNRMNKMMSEPGKNISTPLFLIVNNLNKTLQEMKLKTVSQPEVLAILNIMLKKNKITRVGGNWQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUR5</accession>
    <name>V7PUR5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUR5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB62880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="378" mass="43621" checksum="2DC029EBFAA7F2BB" modified="2014-02-19" version="1">MTSVNQSRGASGAFVEFQVVILTNDENGFSSELNENTCKGLLKVSNRCMIYYIVKNIIEQKLKYITIVVNNKYYDDMVKCISEEFPDNYKFDDKKNKNSYCIDIEPYTTDSNDEIGSIQCLLQIRNKIKSDFIVVNTDIFGFVDFHSLANLFRGENALCALLLLEENDVNNNNNNNKKKKEIADEYLNLENNVWVCIDKNSKVVSISDAVSMKQDGKLKIPKINLLHHKKFILKTDLVDSHVYIFKNYVLDIIEKKKKFSSIKYDLIPYLVNIQNMGKVGEYYNKSEFKFNMYKTLINEYSAEQSQNENVGNEANSNGMANVNEHIENVVCYVQPKMNGFCQRINNIPNFFKANLLVCLINYPTNYPTNCPTNYDLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUS0</accession>
    <name>V7PUS0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUS0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="243" mass="28957" checksum="8252DCAA7A85FF1F" modified="2014-02-19" version="1">MNEKARDAVFEKKNEEMTTVLNKNILFKEYNNANDLKDTFINIKSDYSIESEKEKNNISLFNVLKKKLKGEKGCTRFLIIFKISNDENENKTKINDIIKNIIKEKYETITGVCLFVNIYFIILLESPDTKNVFNLLHDMTNIKYISELKILYFSELNKQKINEDFYFFEYKIEDQKGILTECNFVDEIWDLYINILNLCCFIKDNDKKDIFEKNENLKKNFSTLSNFYTNIANEYIWKIDGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUS1</accession>
    <name>V7PUS1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_01684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUS1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB61883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="523" mass="64389" checksum="D7D1E701B5E2BB4D" modified="2014-02-19" version="1">MNVVIWFLTSLVMYIFFLNYESLIYLMNESLNKILYKYNIYKYVEYYLHIFLEYGFVCIYVFVAFQPTKNVYKKRSKYNYIFAKILLIYFFFFFFHFIINIKNNFPLNAFYLVIIIFHLSEFFLSFIHNKNNYNYYNFLVNPNYGYVYFFILTLIEYYTKIFLFVILHFCEKWINKRILHNLLIFNYFFFKNYIENYGICIYTYPDKIVLTRWTNYSQKNIEIYSTFRKSAFLHNNNNNNNNNNNNKINNIQLTKDLLINKFSPFGKVRNRIFMTSLSNKYKIIATNKYDTILNSVYRKINKKNKEKENYKYEMEKTNNIHSLSINIDDIILDKYQKCLFTNQISNILNKPNIKMYNLTNSFFIKIILKYGDIFEKYDIPRYYNKKYNNYYLFIVLISLLFSLMGLILRIFGLLHCSKNFCFYVLNADLLINKYIKNKHSLVTWGLYKYMRHPCYTGWFYYSLFLQLSLFNIFGFFLCFIVSWLYFYNTIKREEKFLIECYDEKYRKYKAQTPHIYIPFMKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUS5</accession>
    <name>V7PUS5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUS5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="153" mass="17785" checksum="F92285DCBC6C222D" modified="2014-02-19" version="1">MAMPLNCLKKTHGSLPYNINHKILGNLYKINTNATKNGIKTEIINEKESYKLTQNIDPGNIEYKYCSYLKPMEIKGIKRADRKFDYNSSYVFMKKQNDFKDDLSKASLLTKYLYNGMKIPLPPKRYKLSEYVKNKALKNSTCNVFYSTPLFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PV03</accession>
    <name>V7PV03_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GINS subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PV03"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19741" checksum="26106EC91D037EE8" modified="2014-02-19" version="1">MSAKSPCLEILPFLFREEQITNRIQTFPTETMKKAYLELKGYFEQYKIYAEKLINFNGSMNDENQRKEKLTIKLRCEYYAVLFSQSSKLLNEYINFRNRLILELAINVNGLINSIHPNIIQRLNEDEKKELQRYCENIRNERTKSKLQNVSFFPTFLFHNIKNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PV17</accession>
    <name>V7PV17_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PV17"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB63411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="151" mass="18023" checksum="A9B82D8361335DEB" modified="2014-02-19" version="1">MKYTAFKNSLRFASKFCQNNNYKLYMNSVPQFSTYAYGKYLKTNPLTNRLDDLLKKNSNLISIISLNGLDDLITQSSKIESVSIADWLLNLVEEYQSQERCVHIMSVYNIFYNYIFQKSEICLMRSYINCLYMLHIVYSIFIEFFYFLLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PV26</accession>
    <name>V7PV26_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_01741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PV26"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB61988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="43133" checksum="B9DAABE2D6613462" modified="2014-02-19" version="1">MNSIVYKKIKLNDDVIKKFEVLRAFKYKHAITRNISWSYDGELLLTSNKNDSITIYSLVEGSSYKTLQSKNCGVDVVRFLDNANEIIVCSTKSNNSEHKQFLRFWDIKENKYVKSLPQIGNICELNGISINTNKKLMLVNSDDCHVKLYYFNCDSPLIIYKSNFKRPVSCFDNEGLIFIASYGKKEIHFYDLLMYNRGEYNVVSLKNKIQHDEFITNLLFTPNNKEIIVSTSKSNHFKIDSITGKFICSYKYSDVIPKNKQNVHYNPRTTNNDFIEEDKNNNTTSNQSINIQNLYDNNTFQNRPYSLFVPTITPDGKYIMCGWKDNGIHVWKESGEYMTSLYGHAGPPENVSFNPKCAILASSCLNVALWQPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PV32</accession>
    <name>V7PV32_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PV32"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="128" mass="14953" checksum="68E5887A4411A523" modified="2014-02-19" version="1">MKYTAFKNSLRFASKFCQNNNYKLYMNSVPQFSTYAYGKYLKTNPLTNRLDDLLKKNSNLISIISLNGLDDLITQSSKIESVSIADWLLNLVEEYQSIHFILCNYNMISLCIHSYYSLNFVPPFLFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7PV36</accession>
    <name>V7PV36_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_01746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PV36"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007732437" description="RRM domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="157"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB61998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1176" mass="139655" checksum="0F0B2E34AB7590EF" modified="2014-02-19" version="1">MRIVHLFVFISMLLFECKKQKINSYKIGKSVKSYNCLRFSKNDDVLSKKNVVDDDKLTKRENIFNKKGRYSFSPIKRNSIKDIKRKIKYSNKNIKLKNNKFYRKKEIHKSLIDNINKEVLSENIASLGRNNLNENENNQNILPLPLTNIEEQGYNCLLLCKGLPFHVSDDEIIKFFSPYKIMNKYIIYIKDKNGNFFGDVLVRFQNKEEKQLALKNKNLKFLLHRYIQIYNINEEHYEEYYNIGYKNPPSYKNYVPIKNVIVPNYLDKYDNIEDEFATTLPNNNNSMLDRNNLNDNSYEYNDEDTIWIKEHINKKGILLENLYTGKKLIGKITSVHPYGVFIDCDVYVKISKNKYIKILALLHKNKLTINIGLPSDPLEEQEQKELILEKNMNIIVYVDKIIKKKYDIHDAKENNLIFFNLTLDSSITEEKIKWFQKNKLKKDMLLKNNTKNEITSFDQVSRSNFKETSLLHKNNKPMNRSNRLFFINKIHDKYYYFINLKDRNKRKTGKDALLNSENEEVPQDIKKCKQTNDEHMKNGGKNGGKNGGKNGGKNGGKKIKMKKNKLPGNEIFDDEKDEFDDIFNFQNNEIDISEEQQNENSKIELSEQDENNMVESVNTKIKKKGINNYNEEVDGILKSIFSDNKNDGDIKIKGKNKLNKNYDKKKKENSQKINHIKNEDEIRENVKMLNLEKINERAQWTNDIRKEESILYSKLFGLKTDINDFYSPNDLNHDQIENKMKNPDDVESHSNIVEDKKDDYVKYNENEENKIVSNKNDKNNEDCIKNETSDICIDKDIHINTKLNKKNDNFLNILENNNDEILDFSNLSKLSIEELKNNIYKKNYLLPIDVSKESLRNRLIEICVCEKKKIKFDNFPYIRYYLFDFYLSTEEIKLIILCNKKFLNKKNINKIFLDTLKINELKYLLHQSMENFRLWEPNDSVKKKVLNLNKDLLLKQDLTNIEDIQHDNLIILWNDFKDYMLNCVYVPDDGNYNILDELENEDFQDSENSFDKYHTSNNNTNTNKYINIYISRMRRIEKEGFLLNNDIPFCGTLEKEKNIDENKNKYNNLDPFKNAFMSLEKQLQSEEDHDLPDKIDFKEAMKILNDKSHLKKLKRSFNNESEKDDQNYIQKIIHHILKNKQYFDYYIDEDLLKKMPYDELIIMLDKLPANILEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PV38</accession>
    <name>V7PV38_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_00610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PV38"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046789">
        <property type="term" value="F:host cell surface receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.20">
        <property type="entry name" value="Duffy-antigen binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.170">
        <property type="entry name" value="Erythrocyte binding antigen 175 region VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042202">
        <property type="entry name" value="Duffy-ag-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008602">
        <property type="entry name" value="Duffy-antigen-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021620">
        <property type="entry name" value="EBA-175_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043057">
        <property type="entry name" value="EBA-175_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05424">
        <property type="entry name" value="Duffy_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11556">
        <property type="entry name" value="EBA-175_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140924">
        <property type="entry name" value="Duffy binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007732441" evidence="3">
        <location>
            <begin position="22"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="790"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Duffy-antigen binding" evidence="4">
        <location>
            <begin position="152"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Erythrocyte binding antigen 175 C-terminal" evidence="5">
        <location>
            <begin position="702"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB63005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="814" mass="93730" checksum="F903807AD4034FE8" modified="2014-02-19" version="1">MNKIITYFSFILLMQYSLITCNHDKKIVNLLKRTYESFQSFPLKNNSGNRILYELKESLYNIENGETWGDLVSKDNEILGGKDHILSENYTSDSVNSKKESNFLETGKISLVEKNGNVNYKDYFDKYQVNECKEKNKNEIHAWICDNEKQNCIPSRRINLCTKRLEIIPDTIKIPDNKTKELLMDYFKQFIYKDAAREGELLLNKYDDKNNNEYCNDMINSFGDYKNIVEGTGLKNVANESLLELKIQNIFGTDDNAKRNRKTWWKNHEHIVWKAMVLGKNFNETSNYKNVCTNYKLEDYHSQIERWTREWIQEFSVQYFKEANKINNKCTKKSNISTESICINNECKNACNTYEAWISVNKSKWDTLLQRFSQFNKSYFSEETCRDKAYNSLMIEFKEAYEANFENVINLDDDHYTGLCVCSSVKPSNTPINNNLGYKQTLETQNPTDASQNTLFPPFSTGTETDLFKEDDDDNGGFDLLSYNNADAQNLRNSTPTDQVGVNNEQNKLNQNAESNNKYELQIMGNHANSDNTYHNIIIPSQENNIYTSTPESVTINPTSTSNTNENQTLTPNSTLTPTLTSNSNPTQIPTQPQPQFPIPPQPQFPIPPETQFPIPPETQIPTPTLNPNATNKGVKEHHFNTNGIENGNTMKDQMNIPPIKFNIDPKHDNTINGGFSRINNDNDSENANKLGINEYEHRDIKKSRENIIMLANENVCNGNPGLKYCESINNKYFHGTCSKSQTQNLCCSISNYCIKFFNINSKKYYDCMNEEFMAPDYNCFQKESYSNQYYYATGGIIFVIIFICASIGFSGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWR4</accession>
    <name>V7PWR4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWR4"/>
    <dbReference type="OrthoDB" id="10260455at2759"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039879">
        <property type="entry name" value="EFC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="14243" checksum="122770CA030196DC" modified="2014-02-19" version="1">MNEDLEYIKNKKLSEIFERLLGYIYFKKPQNIVEAIIQEVDKLEKEKHVKNVFDSEDIKSMYNFLNVENNKYMTKEKCILGLSQFVLTTKQREHIEKTEIEDNVDFEMFTSHVGNIINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWS1</accession>
    <name>V7PWS1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_00660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWS1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002771">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB63072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="103" mass="12463" checksum="1E359E2380C7A115" modified="2014-02-19" version="1">MALSTRKKKKPRNTINSKFLKIRKRKRDFDEVYNDYHTKPALPYDVDKKGCGQFKCYACDIYFINDDAMKQHEKTKKHKRRVKLMANEKPYTYVSLYMYISHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PX33</accession>
    <name>V7PX33_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PX33"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="610" mass="72493" checksum="D4CB596417B7A698" modified="2014-02-19" version="1">MNKDQKIYQVDCFCECDMEDDLTEYDAHFNGIGPWPSFYELKKNNNNYEFKKTDMEIEYNISYDKKEYFEYKKKMLTENETKCDNGNDNGNGNDNNNNNNNNNNNNNNNNNNEEESETLPTTVDEVRELYYKKEVKTIKEAKYEFQKWNERSKYSRKNWRLTKEEFELLPYETQQLYLKLRKGYKKKNDEIIEKYKEYSAGGHRLLTMDQFDEKNKNNFYTEDENEQAKRNTLSGVGNEQDAKKNTLSEVENEINNNDPNEEFRLLENNILYSKPKSPIDNMLYEWDDPLNCYWRERTKEVVRDVIMYDYPYKELRRASNLDLYDISWSAGKMDIYITVEEGKNYKITLFDLKQLIKKIAKRLKDLEIEEDIYVLPFFELIVSSLPSKNILVCRRDWNQNIGREVICFFKNKNQEPITGTLLGSPSAFHVIININNEYIENVLIDALDKIVIKDELKKEDANDNSQIMLQAKIDKEMINTEDGQKKEEVEVEEEEEEEEDHVNNFNDENSKLSNNESIFSDVDELNDSDLSEIKKLKKNNQLNNNNHQKDIKTIQNIDNIDNDGNSNIINEFDEYETDDEYETDDEYSNIADNDIDSYNDDYDDSYGNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PYV2</accession>
    <name>V7PYV2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spindle assembly abnormal protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PYV2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10142">
        <property type="entry name" value="HD_SAS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="8">
        <location>
            <begin position="168"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="378"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="527"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB63348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="710" mass="83074" checksum="FAEFF84C1D29A419" modified="2014-02-19" version="1">MNSTHNYIEYSFSNVDNLDMNKCVANNCIESVYSYDDVNEKRDCIINKTTTISDSNNSNSNSSNSNSSSVVKPIYTGNINVVEIDYVQGIIKNNYDDINVGEKNGIINRNRNTDDVLTIVECGKGGNINGNRNQNRNICMNQNISNLKLCNNLDMSFIYNTYDKNGLLYCKKIKFHVKGDNINDHIIPLVVKINTLKNNMGKQYMRLELSDDKNESFFYYLDLFEENYENIKKEQKLVINFNLFPFKFIDLLEECVLENEQCEDIEDQRLNAVLILENIVKEVNTKGYGRDGYISSYINNNNDNKFSGSTYEKGVLNLVEINQFKELTHLSLVLKKADNENVIKYLCNNIKYIKEYSEHVIKKLNEEIINNNNNCIEIKTLQKTIENMDIKIKNIKCNFNHTMNNEIQNLKEDHQKIIERKEEMFILEKNELKKDVEILKQKCNEYNEINKNNEENIIHLNSKINKLINEIKEKNDYLSKLTKEKEIIECEKCKLEKDNNYFTIELNNLKTKYEKECENNISNNTSYESIKINNNNLESELKKYKDRNGKLEKEINIAIDEINKGNDIITKLQTQLKKIKDKLKNKTLEYNNLEKNHSQNMIEMTKIQSQLSEIQIKLSEKEASESNLRRDVDTLQRKNDELVKDLNISREVNLRLNKEVANNNLDIYSVKMNNIGAAPTISTGMLPHKYNHSQSILLIYMFFFLNLYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PYX1</accession>
    <name>V7PYX1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_00163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PYX1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB63368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="269" mass="30702" checksum="1587824623B6B396" modified="2014-02-19" version="1">MDLLLAKAICIFAFLSVATGGCAIPYILGLFGKRNRNKYESKVKNILSNLNCFGAGFIFSIVMFHLLPETIIIASSHKDITIFKTHDPEMKILFIFFFVFVGFCMQLALEYVLPTDAKLCCVDHGAVRFTDDNNHILNITNHTLDNPNPEIPNASINADIHYHPHEGDHSSHKNRLTKILDVLALQSFFLTISLAIHSGIEEPKSQDNSTFDFYFFIAPWDNCWAYGSLIRRKSYMCNKCSIYRDAAFHRLRDTSKRDPNEVYEESSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PZ63</accession>
    <name>V7PZ63_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Plasmodium variant antigen protein Cir/Yir/Bir</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PZ63"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01590">
        <property type="entry name" value="yir-bir-cir_Pla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB63463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20279" checksum="8B6A45F5F3844BDC" modified="2014-02-19" version="1">MDINISNMPKFYKLLKLLCSMNTAYTTGKSNDFSEDAKKFADEYKELLDSDNNNNGNSYNKILLVLSNYYNNIETGTRFNNTSITRPKLPTEKTPKKDNSEGHEVTKVTEQPSETGKLGITTATPSSDITVSDSSLVNKLVIVLPILAAIPIFLGIAYKYSLFGFRKRSKKQHLREKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7P9S1</accession>
    <name>V7P9S1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1733"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1734"/>
            <end position="1748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2048" mass="242884" checksum="E823B1A272A564F8" modified="2014-02-19" version="1">MSVYVCIYITFKFFSFDRLLNELSQSKKLIQKIKKNGLLQKYGIESTCEDDRYSKYKSRNDPIKIICNNNLNKKNREGKNEEKVDPDREYPDFISKNNPFKPKNDNVDPLKKYINKDTLFSPKNNLGLLISNENCLFQRILKTVEKENIKNKNEKYKKRHNKLQKIPNKLENINDKVNAENIKNHNEKQLAESFMKSKIIALDKNQTNGKFKNKKKGKVYFNNNKIRYSSVDNVGKCSVNKKNEHIHNSCIAKSGKNNKCSNPSKGINKNISFQNIKEDNIIYKKRGKYISTNYFRNNYDRDENNKIYIYENENRHNKGKKKMRNKSDRKGKYTIKEKLNNIVFYNRTQQSKNYVNRKIKLRNKELELELEKNNHKYFYTFCKNFQLLALKKRKKKKFEILSKSKYEKINVLSKFSQLPNESGNEKVKNETNCKEKIITTYPNDINDDTENPTSINICTGKTNCPNITLKNKEKYIINGIESCQNDIYKSNKSDQEDMQKEMEIHNQMKKVKENHKDNIICENSPQNNARERDIRHTIFNKFFYNNKIKEKDIIDILSFYDKRKNKLKPLLVEENNYLKYLKDNILVDTNICNGISPNENSNISIDAYTNEFIRKFTNTYNNICEKYANEWKCKRFVIKDEFKKDKSEINECLYRLNNYILEKNKLNNECEKLINSFLNNDNINDNTKKEFIFNCIYNDQINFMDIYNQTESRIEKIKKYLNEMEKGNIEKREKKTITNQENIMLKNTLNCDTKKEEILYSEQWNKKSPFNYIETITPKFININLINNKNMYSYIRRKKLNIKRSNFFKNCHLSKSLFKLEKKRVYIIKLYILFSQNITKRINEKQNINLHIFVNDIKIDSRYYCSFTSNNNNKIDLKKYCRSISNNNSIFFIKKNKYYYCYTILDNINSSYRKYSYINSNKITNKLICEYSDILDHVQSSNSTCVTDKDIIIKKGKYFNKKEDENDQIKEGHFLCGITNSVNQFNFPKNDCNDNSNAFYLKSIENIKSNGTTKYTENDLEGEKSESFTDAHDINIGNLFDKSINIITPNISFSKSLGEKINRINTNDNNNEIPNLINSYGLIRSLSIKNNFIFEDNNNDKNLENCLEKNSKMYNKLSISQKNNKDTNFILSNKNEYLIKSINLERSNRNNMYLEFSNNNNNKFSTDPKIYSSGALKNDYLNISDMLHNREERNKNTFRMNIYESNNMNKKENTSKLNNSYTNIMNNLCNNKAKLRQEYKKNNKNEIDAINKEILDKIKKLRNISTKKKKKNPQKLTSKILSHRYNENDTQHNGILDDQLNYEDKLNNISGAYQLRKKNNNDNNNRIKRIKDRIATNAAIYNSKAKKEGNYFDDHSREMLSIIDSDNYIKDNQQNEEHTYKYLYSDNIRRRKHSNGNTQDDNITYDNKDELEKRKYNIIEYKDGNETNGYSIYSDCSSQDILDKSKIFKNTKKNKSNKLEKYSESILEYYKSYNQENIVSYNEEIKNDLNEDAPYDVHKYNQINQLDVNINSNYNTDGESNAINLCLSTKNIVTDEMHEIIEKLRKWNKDLENDNNYIQCIYCNKYLFKLKNLNKKNFNLEKTNNVNKNDCICVICKHKIKILNKYNNNLISENALDIKKEHSDDLLTENKNNGNNKFEGSVLYLNDPRLENISYENHLKNNISTDSNSNNENVHAIFNNIDHLNDLKNEYLHYDKSNFNIEYNNEIDSSEIIGNQLYHDKILKPSFNFITSKDNNDKKDSGSDHESKNFTQPNNNSLKSSCLINVKNDVHNSEIYSSRNDNSSEHSIDANKTVYKFFSHENIKYESNTNFSFKIMHSNCTEYINQRKHKKCVRNLHIKNNNPHHNYINICTSSKSEQMETNGKNEHCQNKVQKNRKQYKIIKNNKQNIQSDYSNDMDGDEIIGYINDYRDNFIKSSYPNFNYFHNNTHENCDQTDDIFIGNNYKHFQSNVSNLNIKNTLLKQILCNIPHSNYKKNASLLNKKNHSLNPLLEEERKHRKHYSNNSNINKNTYNLNYKYLYTSFSEQNYPTYSDDDNDSMFYKINSNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBD4</accession>
    <name>V7PBD4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="6">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_05242</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 6">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6"/>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="8">
        <location>
            <begin position="525"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="865"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1739"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2098"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1739"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2135"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2157"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2170"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2221"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2239"/>
            <end position="2254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2255"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2278"/>
            <end position="2298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB56876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2558" mass="297123" checksum="9B05DB824286EF10" modified="2014-02-19" version="1">MYDINSANCSEIKSAELGVLSSQELKRISLGKYENQLQEFEKVSKDGTSNRITYDPRFGTIDYTQICSVCFEKHDSCLGHIGHIEFVLPVFNPLFYKDLQELLNLVCYNCYALCYSEDVIFLLKHIYQLKSLNEIESSNKFIIKKNNENEYIVSEIERLYNKICKESNITMEDIVESICQDYENSFGNNEKDNNENDSFEDRQTYELWKKINDDIYNDDQTNEADFSKESDNKKKHNYSKDKKTNQEIENKETKEKIKFLKEKIKKYKFDISKLAFQSNYNYEEYVILNKAIKLHMKKGANCSNCKFRRSIVAKTSPKKDTINFVGIYTNNSFFKKYISKKSKNEGFEENGNNSNDDNDDDDTEVGKANKRGKEIKSEKIKNLNNSENGIDKFQYEGSNNKDGDEEDESFKDAVASYKRKTSREKCTVRLFSFQIIDLLKKIFVENNKEIINLVYPFTKKDGYQVFFLYYMGISSNRFRTQSRGIHKRTRITNYICKLNNYVKLCINSKKNVDFDHMIEYNKNELDLYNEMFLLFSLRLRQRVISNSMEFNIEIAKSDFLRCYSLIYNNKIAYLNILFGNLQLSVNTFLDSSLIDKRLQKNMDNISIREILDKKEGILRKNIMGKRVNNCARTVISPDTFIETNQIGVPIEFAKTLTIDEHITENNFEYVKKLIENGPDVYPGALSYKDGQGRVFKLSHSYENRMNLISRLTHILQKGKHETLVLHRHARDGDIVIMNRQPTLHKFSIMAHFLKIFEKEKVFRLNYVNCSSYNADFDGDEMNLHLLQTPLARAEATHLMNSDFLFTSFKDGSPLRGLAQDFILGGLHLTSLETFLNYDEYCNLLQCSLNGLLRQKNAFFFSKTKHRNTSNSSNTKDGNKNSGGNDKSGSNSFRGINAKISNYSYIDPYATNLNKTNFTIKTEEPTILFPKKLWTGKQLISSILKTIINELAIETYNKNGDNSFMENFKGINYVAKAKTDPELWSFDPKKECEIIIKNSELLQGVLDKLHFGASSNSFVHLCYELFGPKSAAVMLDCFGRLFISFLQLRGTSLSLYDFILKKKAKVEKKKIKKRISFTGFYLQNLFVYTIGKALNADMNKMDEYSNKKISNYEEGQNLFSNKLYDIYLNKSQIINKYERKLEKKMNIEDKHMNTNICLTKKNIPNKFNLFNDKELNLKKDLYFITFLNKEIEEIFTQNNMLSGNVKNEESEETQKCKYSDSPHLNYIIKKENYEIFEKCLVGKNKLNSLEKQGKDGTICEGGTIWEDESRYYEFVNSIINKLYNSINNPSFYKTSTFTSTQVVKVIEKIVNFLKEAKCNKKLKVFILFELFQNENIVKYFPSLIDFASGLNTNISSEEIVETVINNILLKKDLKLETEYVSSLNTEKIKFNDNKLEKTNDVILKKYLHLYSRLIKIEREKKGKINNNSPSKLKHDEDEINETKFENSQNIGIDNVDIIKNCLISSLPSFALNEDITNLSYNNRYQYYEKYLNIKDEKYSHFKFYRMKDVFHKLDFLINNFFSLKRINFDGLLDSLFQPYLCRVSSGTNNLITMENLMNKFLTNGFSNMIFTGAKGSKVNYSMICGMLDQQYLEGKRVPRMRSGKTLPSFHRYDYGARSCGLITDCFLEGLRPQEYFFHCMSGREGLIDTAVKTAKSGYIQRCLIKSMESVILHYDGTVRNEDNSIIQFLYGEDGIDPSKTAYLNLPSDLINNYNISFSKYLNYGSDQLILSNQRLFAKNDGKKKNEDGKKNEKNGENGKNNDDDGDGGEDDPLIFQYNPYTYIGSISDNYNEKLNNILINKKFNITNYNENFGSLSASLLRSKYFHSLCSPGESIGILVAQSFGEPATQMTLNTFHLAGTENVTMGIPRLKEIFLTSKLTSKPMIYVPIKLDEKNNNNPNQIKNYITNIADKILSSYQSILLSEVIYGIGINRKLIIRDKIENKEIHTIKLDNNLLSKNNKENESNWDKSDICKTANYSKILQVIENTNLNFDLKKEWVHEIVIQFDNLNHFCKVNKHLSIPFILYKMVNIVLMSILNKIQNSISHHNIKNIHFINHEHYDELFDFISEKMSEEFNFAYEKYEYKDDEDEINAKLKYMPNKSEGNKLGDDDDHYNTSLKTPKKFSEDNDDNFSMDGKNEGSDNDKNDKSDGNNDSDQNDGRESDEYKSEQEDKEYDESEEDAENDTDSMLSQNAADSDDDIKHENVNSSESDGDEKKSEKKEKKKEKKKSKLLNETDSESNYSSDESITDSSIINEDPKESNKSKKEDKLNTSSKKRKLTDVNDNIKNEQNKNKSKEINSDSSISSESETELKQKMSKKFSEYLYDYKNRMNKHNLDVSDYEDPSIGISGSKNKLNDQKYIKNLIDKIKSSLLCFIKKIDFSPITWVLKFELSWDVNFFPYPIDFLSYLQNEISKEILFKVKDLNNPKILKGKDITHSGEEYELQIEGRNVYKLFNIKDKYIDKTKLYCNDIYTIVKTYGIEAGRLCITKELKKVFEAYGIKIDFRHLSFISDFMTHTGDLKSFNRYGMAACRNVFHKMSFECATTFMIQGCIQNSVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBF8</accession>
    <name>V7PBF8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 70 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_05760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037692">
        <property type="entry name" value="CEP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14594">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14594:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1424"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1229"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1465"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB56330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1917" mass="223732" checksum="70403A7853E9D4F5" modified="2014-02-19" version="1">MSDDEFFRDKCSNSLQYIKCKTSTKIDDILKRRKDKKIKEEHGELKGSINGGSFVGIEKIKSEEKYNDQNKGIYKFNSNSTNKKSTNDSSYDNYLADDYINEDNNLNSFNSVCINSKLDYSNILNRKSLEKKNFHNNNNDDEDSDNSDEYDLYGFKNIRRYSKECSFNARDKIKDNAEKKYSLEKYNTIDNIGPIAPINSISGDNILKRGIKTCTNISEYNSMNNKIEVNATSLENVNKYENDKYNSMEYKNDDYVKINTKDSEINQREEKNIYKSPSTDAILSRIKSDDNDNLCDNKDDIYANMTDLNKMYMQDGDMKKLYTQDGNINKTPTKTFSKSYFEYLKFETAGKMNISELETPLNLKDDKEDYSGNTPFIAYYLAGQPENKSLNGEEDNLENKISSFNKEIDKDYSKENFHEPFKFDINTKEKGDEPEPEEAERTEIEENTFNIIKDNSFSKKRNHSFSNNNIIDVNQMNPNDNKDELDIFRRVSVTSKKYNFIKTEEEYNDMLKERDIKLSSNKSVSRKSTNNANGLDILEKVNTEKNINNNDVSFTDKIFSCNNFNIMNTTTFKDNLFKEPKYSKLDHNEINFEKYKGDMLYYSINDKNGINENENIGLSKNITFFNTNEDNYDQIDRIDTIPLNKRLSMYGKSYDDIINEGNINNNNDNNNIYNNPNTLGSMKFIPNSSVMINQWQFKDGDINNIPINRSKSYTNIIGGNSNSDIYKNTNNINYNNKFMSNNDFKSGYQIVDTEGENINFRNSSYESKIRNIEKYINDNKNNAIRKSNYINKYMTTHDDNTFGGDTINKMNTNNFHIDNPNLLINNINNRIMGNSVKGDNINKVENYEQNTSEQFFKQNDITNYSSGNGGDNNSKVINLMEKSNTFNKSIISENDGFIPLNKYIANRLSETADFGYKESPYMEESKSDEHNKNFGIHTLGNNDINNNNENNNGYNHDITKKYWVDFMKKSFDNIDVNEIKNKILNDYAKVNNNNSENKANMDMEKKNSFYKDPNEDTLAKYIHEQIKGSITEVVEKILSHKEINFEINGEKNNIIKKKTESFNGDMLSTQGNNYLAIDNVKKEEGHYRNNSKINDDDNNNNMNASVSISNNNIDNVPLKYDFKKEGKNEEIGKRETQIESCEEVMDDAKLKTTEINNEMIILEEEDIEELYKLNKHLKMSNVKKIIEIKKDDCNKKKQIKWKDLLSNCINVIYYLINDNNKKTNKMNSLLSDINNISEFEKKIDNLNKENQKLKLEIVHKNEEIKKHNYKERINLNNKISDLSKKNINYEKEINIYKNKVATLNNKIINKDNEIDQLKKQYQIILDEIENCKKDAKAIIKQVLNKKHTNFIDKQCLDISKYYNIQINGLKKEIKNLKDLIKNEAKEKILLNKKLNELIQSNKDIGSNADKNDLIETGIYETDDHDNKYDEKKSSDDNVSKEHTKLGKIKKGEDKQKNEDKYKIMYFNLVEEMKEIKKNIEDQKKTNLEQNQEIQSLKNQVNTSEKFLDVYQNIFKENPNLDKKINNGEKVTEQNHTDIHNNSSINVSNFSNVDRLNNYDYNNSNNNDDNNFIDNSNIANEYSKQGLIQTNKYKQNIKSMSSMQRLGLSKENLEISKNGIENTCKKKDIGKKNDNSGIIVSAYNEYKNNKYPMEGNYSCHTKMYENPYLNSFVKMFIENASHLGISLDNFKSFLEKPENDYSDKKCKNSIDESNKILYNNLMNYEKVELINMFVNICNDLKTDNIFIIVQFVKFLSFIVYEQLPLFTSFYCNVASVTSMDSTNPVISLASIISLNSLKFEECINVIKKWKDNYINTNKYYQFRKNVLLIFQSELKDLRKNQVDFRCVDIIKNMYQKNMEISKFSNDPFEKAESIINKQSKEIISKIIKAYMNLYKIEKINQIIPHMNTMNSKVHLIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCC3</accession>
    <name>V7PCC3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_05463</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCC3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="290"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="478"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB56630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="637" mass="74779" checksum="139D49E4C0D410F5" modified="2014-02-19" version="1">MAWGLINIQKNKIAKVCDCQRIKCFFFCNNNQIYGKFKNASIPKSFKLKQNATEKGCKGCKGCKGYKNYESCKDYKIGNSHLNNLNKTKNVYYAISMNCRYISSNNNEPTSGEHSINEPSSKDSQHNSTINLIKKKKPKQCVDKTENKISKYYNKGTNIFKIVIEFIKKSGSVIKVIIFQPSILKIHYENLKKNIKHTVDWVKTGVLLFLTNMKISKNLIIKRLKGHRLSYSEYKLLIRTINDMFKLIPFSFFVIVPFAEFLLPVVLKIYPNLLPSTFKNNDDNFNNIKKNLYAKQQLSKFLQQLIEEKEKQLNENIGIDSDKKKKILNKFHQQLINKDEEDINPFLNVNDTLKIAKIFKEEFILDKMNLKTLQTICHLLGLKPYSIHYHVVLQLRHHFLRLQREDRELIYEGVDNLKKNTLIEICKDRGMNFNTNENEMKLQVKKWLELASIKEIPYILLLYIRCVVVTHAIMDIKNENDKQNISKFKNENENVKDKNGKDKTIDDKQKLIQEAKEKLVDLKMKEKEIKKNINKETNEDNIIQHKEMKTNINFIKKKNKYMQNELALLNQICNLQHRELQLAFTSLTDLAEKKGKCDINEIIKTLSQGLVDIEKHINELNAHKQIEMVIILFQYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCC6</accession>
    <name>V7PCC6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1144"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="428"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="611"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="929"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1144"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1339" mass="160070" checksum="EB57512780897613" modified="2014-02-19" version="1">MNNCLSLKIKSIHIKLNNIYMKRNQVEKNIIDKIRQIEIKFSALNQENNEEDDTVDTKNNDEGLKFKDNVCLEKSEKNEIESILLQNEIEKLKKVLNKYEEDLKWLKNDKEKRSIELKCSKKDLEEEIKKNNEYTNKIKCYEMNANIYKNDNLKKIQEMNEIKIELENLKNIYNETYVKNKLLYDEKNELTLVNNDLKLELKNVKTDLETWKNKEDIFNKCTDKIHNILIYLKKNNDQNVLYEAFGNKLDKTNDNLLINADKDIDEIYLSIQNLINMKKYYEEKKQELEETKNEIEVVKNNFMERCKSYEEMKMKMEKLKILEKDNLKICNDKKNDEKRISELKDKLTKEENKIIELKKKNYYNVFKLKDFKEKERDMIGEIKKLKKHIREYKICFEKNRKINKNQLKYMKGKNKRLLNNIHGINFELKKCVSKINKINKNTESLKREKENVQKEIYFMKKKNEKLQQELKEIELEKKNKESKAQTLNSNIYKVCTELNKQNKEYKENIKRLCCCKEELKEALKKKSCKFILLKKNCYYLKKKIQKQNNELKKHLNIIKKQELAINNCSEQNEKLSEELKRHNSLIKSRDDKIKILENNLIKKEEINHIKIKENANAIKNGEIELKNINEQREKLHEQNKKLNELVNDLKSQIIKEEIKNTEINKNIYTIKNENKQIIQNYEQKLRDKETYIEDIKNELKNVREKIEEKYDLHTKENKKILNSKIEKMTNEINELNKIKNSYEIEIKKLNNDWDKLNSQLKEKESENENLANSLKEQENVIQNLRNKIKEIEECEKLELEKIIKKMQEENEIQKEVIMQKSNQDKIEFEEKIKSIQEHNKIMIEELKTKWKEDKENYEEKIKNINEKNNSIIEQIQEDCKSQIKRVTDLCNVKTKSEVNKLNNDEILQKKIQEYSIMLNNKDEEIKNIINMYNEKLQLQNTEMENLINECEEKLKKAKINKKQISEKDNQEDITTSDAAYRVGEREARVTEREKKVKEVENKVKEREKKVKEVESKMKERENKVKEIEAKVEERENRVKEIENKVKEIEAKVAEKEVRAVEKEAHLIEKEATIMEREIELKEKEDKINKLQEEINEKKKMFNNTQLNTSNNVIFQENKSENIENDLQKSTTDFKTNKIEDINKKVKERNETNSESTENEKIGEENISDKNRNIKIEEKKEKNKKKKEKSKNGKKGEKYNKDDLLTLELLEEKYLNVQNKLIEGETNHRLYLKSLIKTLDEIIEMLNIKQSTTLNNQTVNSPPLNGTLLNDTTISDAINTINFAISSWNIFGEPTSTNPIENTQTLGENINSISNFDEKNSEDLKNIVTEKLQLIKQIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCC8</accession>
    <name>V7PCC8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_05464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1153"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="968"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2025"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2085"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="970"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2025"/>
            <end position="2044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB56635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2531" mass="302509" checksum="EFC3E3C5790F1446" modified="2014-02-19" version="1">MKNVILNVLKSIAINYNITKYVKGFKNIIFLSFKHIIFEEFELNKFSINNIFQNYIIDKYINNFELKINELDSNGSLSPPTNKFTDYLIYLNSLNYKKKELLFNIFFCDKIEIYLDTNNTAYFYDSLLVNIETVYVLLSVAEIDLGRSGKDVKQSGKDVEKSGEDVERSGKDVERSGEDVEQNGKDVKQSGKDVEKRGKDVERSGKDVERSGKDVEKRGKDVERSGKDVERSGKDVVEWVEVVIFFTIVSDEHEEYLKISLTSFTIYYDLRTHLISDTDIYLDKNKYIFFYNYNINFMHKRDCLVEDTDLTCIISKSGKIGKGGKGGKDGTNLDDEDAQRIQKYAIDFVVSSFKINLMHDKFYDLFLFIYKYVYLLCNKNDCLRKVEKKKKKKSKNYYFSKRIANIELNINIEMFTIVFYYNYYHNFQIVLKDINFFIFFMKKKWINKRVRKDWENSSNTIIFNSYILKDLIFFIQSIFIKEEYTKLLIAMYTQKKKFIYLNKKNVNVRRIQYNYNNETELLKCYNLENKLNKFVDIVSYGKNGKNGKNGKNGKNGKNGKRGSKNGDGAKYGFYFRIYKKEKGIKNSKNRNEYINNIYIYIESIYLKIKNLNNIYSLISNIPDKFVFILYYIINKYKNLKENSINDEKYKMKYQRNNDIYLNVRLNFIEVELKNRNMASFFFCVHNLVLYNGNGKLYPYKRQYSSNFKLLKKKQKKIIFCKITNIYSYIQNDQIIHILLYPFNLFFTINNFFKKKMKIEILSFIIELNKNATEIFKDIFFIPENEINNNDIFYGSKQNNNTEINPKFENILINEYDNFITISNELNMLFSCIDVFFDTFNFEKNNKEDEKYDVSSSFSITSVLNLFENVNMYFSFKYVHIYFFFGNNFVELAQKMPNKKVSDKKVGDKKVGDKKVGDKRCENVLSFFSSANVKRSGGKDGLGKGVEALYIKCEFKNVNFICNIKKDDNNNDNNNNDNNNNDNNNNDNNNWSIDKYSISNKLKIQNFRVLYNFYFFPINIETFIMNGLCVYILKDSISDKEIIKIKTNQGLVKKKKNIFILNKCMLEYADKENILLNRCKWVVNLSYINIYIYSFFINLFYYIYRNNKTKIFEKKNKSNNLNSIIKIQTNYTKMLKHIKNISNDLFISKKIFKILIYILIKKINIFFIFYNNIYSNSDNISKFYNTHLVLKISYFFTKLKNEIINIKFRDTTLIEDYPFHNDNFVCSQNINKIQTYYYIFKPRICIILKDIVFTRCNCFMHELRWNQNKRSEKCFKNEKTLKCGKIECVMTKWEDIINNFGKKKKKNLIKIDEINIKMLNLYNSILFINLYKIKIFNYFNLIEGFNIYLELFLNTFKSSFFSKYFHIHNFESDNEYMIKFDMKEKQKSCKIQNNNINNKMENDALAIDKDIDEDVINNTWSEIVYKMCIFKKIICCVNLISYNHILFSSPIINDDKQKNQKEIINLKITKIELILKRNYIKNLNKYISYFNYNLYTNIYGINIFIKKLKKKYILFWSNFLSFFSKINGYIPKNAIYHDFETKKKKKKKKIRESYVLYKNNCLKYISWKNTSIPLFFKINKQIKRKILDIKFLKKNNNFINLETEQTLSNKFPLSVKLKLTSYDIKNRQNGCSKNESAFYLFLNEVSILSLVNMYVNTVNLFENLSKIAKMGLEYSEIKKKHVEREDKTVEIENRECEANATESVSFLQCLERFKIKMKNIFFLFYGCNMENFIGFYLKEINNILYIYNLKNKKNTNEHEYYFRYINKLTDSVLFTNNVYFNSNKNIYIFEIFNNLANKNNLNYLKGMFYFFKKQKIDSNLLFLRQKKIINNIKKKKQKEYNDKNKKIQNLSIWWDKQLKIGKKINKFPSFIYSNMLLYKIIKLNKKRRISTELDIDNKNDKNKMVVCVKYYLKNKNIFVHIETKHTFKNVCIYFPLYTIIELNKMIDALNCPFIYKLYLSTITNSQNNDNDYIYKQKKINISFDFKFCLLNFKINLLSGYTYSITNVKENDLTKYGIEFRDEPRKSSKGDILKVQTREKSEKNEQNEQNEQNDDGDSATFEMRLEKQKKKKEKGKGKNKNGTEIKCQQLGRSFKQKEVKKNEIEKEGKNILEKKQNEMNVNEMNVDEMNVDKMNRKKRAFLYVFVLKTDINIDIKNKNKKKKIKKKVINNSKKNNVTFVNMNISFAHLNVISGLLYIWINEKPFLFNIIRVQSLFKYLYEYNNSSKYYFNMSRNHKFRLRRNENLINQIENKNISKITTKMNKINFIIMREYCTYNTIDIMNILLFFQNISYYLNWGKRSCKKTKKNIKNKSNEHVKEINTDLASSYDIYNNRKYEGVDTSQHHISGDALDIYSTKKNETNIYGSNRESYYYEEKERKENQRIVESSHLSYNNEVIKLENNLNEKNKKDRYRNKGMENELKIVDEILDKDLCANEKKNSNVNYCLNNQKKKAISKKNVNVIIGSMSIYINNNDLLILNLLREELLFIQKKLKGAKVVYSCKYNYNGVMISSKFSKKKCINNQKKKKKKMKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCC9</accession>
    <name>V7PCC9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCC9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="659"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="784"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="863" mass="102691" checksum="DC26425C75F415EC" modified="2014-02-19" version="1">MKFAVIFLKLLVIIVIIIQEISLSSCIMLNKIFLWVLDSTFIITISYFLFRSVNNIHIYTIYVYSIVTKITIIFFVSFPKYIMNKNHEDILKIDYYDIFSYKIFLVSTCILLLILVYVFLFYIINFSFLNIHNINNENSIFFVIIVQVTIDIIDISHFFCSSYFNFFLYYFRLKGEYYIFNRLNLFLHTSLNKQNLIQFYTNTLNIYEIMFIIYGVFISLNIFLHAYSLPSYSYETVIQKKGGAISNTITRDHNYCINNPEVYFIHFSPLNNNPLYNLNEYLNQKIFNSNSLEGREKESSQKNDIFLSFQNNDNTKIKQNNKFQLNVGGDATSCLKYITIFRLLFTDIPFLVARLFNFVLFLDAHAAQSLFVVKNICFIIINTSRIYRNSKYYNKNDNEDNKMGIRKESEKICSDESEKNIYKFIGNESKDNNEEMKIEEVKHNFEKKKKTTSLLKGSIINKWFKNSISSKKKIIKKESFNEKVNIYKINEASYNRPTNIIYDKIQKYYYFLYIKYNGINLKKNISCYVDDIKTNSIKNILLFIFFICLIAVKITIIAIIYAFNFDNQLKQNLYQITHFHNIQNIELSLMLQIIFIIISVYAIFVFLINFFTYSLFEAIFMFILYISNLLSYSFVLFILSFSPPSYNIFVYFTAQKDILLILCVFIYEIHLFLSDSYMFIYMLIGGEYITYKYRTENKQKNNVNNDYKKIEEVSVSISVISFMVVKIIKYMKAPLLLNRIIIGNNFIKNTRLDNFLYFSHIKEIIVKLIIYFFCFFILEKNGYINFFFLVTLFSINIFISLLYLILTKIYRNAAMKSIIVQSIFSDINRDKIKNSNMTPQINRLYANYSYDHLILFNNSLNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCE8</accession>
    <name>V7PCE8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_05486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB56665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2072" mass="248294" checksum="B8D5FD34991F8C53" modified="2014-02-19" version="1">MKMNKRKGKVWLFLFIICLIVINFKISYDQNNERNLSEITKNEIEYERCQNLVPFYLNNPEYYTMLNEINVSNEYSIKFDITYIYFEYINCNFYINLKLYSKDVNKVELYEYVDNKGILIFSENSKDNLIKYLFHVQDKNENKNENKNENKRVFYFIIYSNKIETSNECVNIRLDIGIGPVALEKGDTKIESTKKGDTKKGDIQIEHHNSYIIIRDNYRYATDGYFNFSLKNNKDFYIYENGKKYGIIYNVIIILEFNEENNINFFSLLSQGKNKWNNFSMQLKKIKLDKNYLHNMNIEYIIKHANADMTCNDMCIKSDESKNGIIFLNALLSNNYIYNFQIRYAENENENNYINNDINYDNENKSNKYLGRNSVESKKEMFNQDNIIYFNFEYNIVNNVDKYTMIDYLKGHFNHENIQNTFFFDKIIQIKDNNINKNNILPIIGFNKECVGENKKECNKYEINNNYIIYGNTIEIDDNFILNFDPNNLFKEETKVNITIEEESFFMFTLESKSENIFVNLLKKNSTENVCNTYYLKHIKDYNLFSYLTKNEKNILKYDKTNFSRHHIKNLSKKIIIYIKCILLEGEYDLKINFEEYNKKFESNNINLIIQPLHIYEKVHSCDRKMNIITDMFYYNLRTENVNKKNDNNVISYKNIYENMWELNNSLFDDFDFIILYENEIFENVDKIIVTINNSIFSDIFIIIFETVKDETHYYIYKNSKSTIEYEIKNKLNNKISIYVLTPSLHYSGRKICGFFFVDIDFIENKKESIGEITLFNNMYKSNRSYIGSINHIPYLIIGYDTYSFSNFCYIPDNKEHILIIFIEKESIIKINCFMENYVYIELYERKHIGGEIKKIKLFEEYQQVYIESFTKGEYEIVFKFNVQNDREMSNFFYLQMYIYQINLLDKCVFHNEDDFGEIAEGSSSVYDLNEVDRKIKNKNGKKNKEIGYFNDNNGFIFENESSYYLFKRYLLFLFPKKIDEKIEKKIILPETNNSGFVLKAELVFHKNFLPYKLSLEEDGENILAHESNIYKNKIIITFNILNKNVKYVKLYIYLYDNVHEKLIKDYCPYAYLNIIYTHELEKYTEHENDEYQYDTMHLPLFLNNILLKRYEYSDDVEEEDVEIGKVETESGNDKNVRVVPFDKKNGMCIGNQKIEYKFITSNNNMMFFLAERDAFLNIYIYKEGKEDIMLNIYKYKDISKFEKNEILPYDEINKDIQSCCEEIFSHSNVNDINISTYFEKGLYIFKFSEKLTYINMIFSIIWVEIPNVNDIVMGSNINNKYEINRYIEENESKFYFSKELKCGDKKGIFYDENKLKDLEKFVIENMFEKNLYTIYFGNKKKEITISNDSKNIVMYERIHICFGNEIFNHQVINNTNYIKENEESHIILTLNVEKECQVYVEVKPHFYYFIYPFKINILSKNSYFKVSNEYKKYVYANIEQGEYNIEISFKMENYINNKIKKIDGVIFDFIIFIYNTSNENKLKNIDFSDEEKKQMVSLKNETSNMNKLYTRKIYKNIFKKVNLKNLNENGIVVNEKITTHKSKYSYFFCYDKYIIKNHQEIFFTLVDNVDYILKVYLAPIYELSGNNNSKNINNDFEHFENFENFENSDNNSESSSLYNFSTNYLNYTLNVRNVFNIEVVNESMNNDYIPEKVIKEKRLKNKIIEKKTPDSNILYTNEDDEYILNVYEVNKNFKLVIKNYNNIDSNIELVLSLVPLKYYKMNMNTKYANEYINSYFKSIFNTISVKTNLYSGIIFENREHSTHIYTRVETSVVYLKNIIMEETFSFPLHVKKGSYIKLNIGYDFSRVNFDVKIMRNNKKVSTSNKIKGNMDNGKINIFENISLFLEEGEYTFQIWFYNLTDNYIHINKNMGFPFYFSLEIFEFAENKNNTSVLLDVYPHRSVYVDKAYPFNIDLIFWSEEKREKHGFMEDEMKKIVYLRVGEIIKSGKIEIQKSYLLPEDMSNLKNNMTLKFDLKDNVDMISENNNENNNGNNNENNNKNNRYLFTFLNNDVKENEVAIETNNTNLNNQEKLKQIHNESVNKSILLEYKKEDSEKIEEKDSYISHNVNQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDH5</accession>
    <name>V7PDH5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Condensin complex subunit 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1442"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1444"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1498"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1508" mass="178448" checksum="0199BBE105AEF51F" modified="2014-02-19" version="1">MHIERKKQMFRLFTLKGILKRFLLCAHYLNDKEIMKIKKMENDQSISEEDIGVLKNIFMLLYESIDYLDISNLVNINSKNCIFELIKFYIELLKYPLIHSVHILCINYLIKIVIKCYDIRFEYNINVELYDIGPHVNIFVKIVNLIFAKILSILKDIKNSENVYYIEEINNINNLIALLFTNILNSCIRIIIPQVLYNDKQKQKYLLNNEMTRTTKINKIKDDELDAEDKIVLNACNPVFSFIEIFIINNSDKYEKTVFTDLIKIIINNCRKIEKKYNVMKIIHDEFMLHIKGEDNKKNGDKYLDKNYLKTKKISKKRLESTASFKISDECNSSVYSETEGEDEEEEEDEEKGREDGKSEMGDNQTNGYESEKETNKYCPVSKIKNKTKSTLEIDNKKYCIVYESVMIRYLNLLLKYMNCEKHQIRNMILDLFLILLKKKKTNKNENIYEKLFRLFLERLEDPNIVVKSKALSILVTLTNKKHHNNNLVRNFIYNKRKEKINMYKIISSNIFSHRSNIRKLTIQYIEVIFETLISQKLNYKIFLIFISNYLYSLSFDSILSVRRQVLLTVNILFLMASNDEYIGKLWITIILSAITDTEETIKDEAISIFINTFMKASINCSMFNTNEKKINQVLEENGMTYFKALTTFSHELKTKKDDYKNTKSDVEVNPIVKNGSITDSVTSDTNQRKYSNNIIKNKEGLEKEREECDKNNDGVILLIEIWEKYFESNMDNYFLTLLKMMTKYDLLNFNLILLCLTQKKNNVLEEFIKGINIFIYNLRYFSIRTWNTFIFDFIIELSKEYQNSINFESILFLLSRCYKIYLMNEKKNINKSNIIDKNIMAEKKIENIKENPEINNTIKTEFLFDSILTDQELANEKKSCPNGILKNIMLKLFTIISNLLNNENNEVNENFLEIIENTIFNFNCPMCFIYIILNILIKKKKNVNQFIDKLKNKIHFFFEKIEIIPYNNVFCNILVTFIFLINHYKKQDTEFLTMASEKLKIVYENVCKDKSAGSNETAIGGEDSDNLNHLGENIIMVKNCIYMAQCVLIIDKDMMNKSDFFLTLEKDLKNSNTCMNILNNLIILTYYMIKNFGSSCNKFVFNLLRFFKHENSFIRYLSFYMLSKLISEDYVKFNNQFFFGFLYLLADKNEIIRKQSLSVFKHIVLIYNKSNLINYMIDFIFVLNNFYSIKLSKHLIHIGNHFEIKNPEDRYKIYCLLIENLTNSEKFSFQQKLINEYLIQYVYDYDNYYFSDEHAKEKKGDDGINTRAKHNNIIPINDEGNEGSVLKDVLLILSSRLMKIKIKKDFAKLEEKNKNIKIKNVESSVKVLNDLMKNILKKNTLPILLSLRAIMLKTKSFFFKYINNLIIYLCIDYKDSLEELILEAHTRNEIFSDIQHFVYTDVIHSVHNNNDIFNKNSNINIDINFLELSQNQMIEHNLEKNMHNKNIRKKGNIHKKKNDDNSDDTSDNSDRSSDYEEVSNVLHSIHNRHQLSNNIKINKKTKKNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDH8</accession>
    <name>V7PDH8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDH8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="223" mass="26674" checksum="9C4EE7EDA6143F49" modified="2014-02-19" version="1">MENIKNSKNLFILLESKKRNEAIMQRKQIYTYIINEDFEMTHKHICLILRNEIESLTCNILIRLCNELIWIINSQKNNNDIKKKCIRNIFYCANKLNIGNTESLRLYMIKYFGNKFIENIETDYIILDKNICKLVNKYTFTRQEIRDMKNKLQDEMSIPINNKIKQCFCNFCINPQTSFTFSKLNKHENITSIAQQYSHYAENIYDAEKKEILAEIEKKLILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDI6</accession>
    <name>V7PDI6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDI6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="34849" checksum="316692F1AE49783F" modified="2014-02-19" version="1">MYIYGENTIEITNLPNNKTNEYIQERLRKSLNKYGRLKILRCLSHRNDPYINNNVCYATFHNKKDMYKCIRNVNIRFPLSLQNKILKFKSLYNDKCNDYHYFYKQEHYNYSAINVALNLFKYLQHNNCFINIKDIYKHVFEYSYYNHKIVSSGISIYKVFNKWEKFIDFFDNLFIKTKKDNQIIITPRLIDDKNLCIYLNNKLIDLKRKTNSLNSVYWRQDSVQLPEEIEAKLNTDHPKKLKEEMQLLSKTKDFYKIHDERHLFKLKLNKERKEKKRLMKNKNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDJ2</accession>
    <name>V7PDJ2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PQ-loop repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_04446</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDJ2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB57591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="25292" checksum="C38BEECCA07FAFF0" modified="2014-02-19" version="1">MKPPYFNVWSENFYHKENILSVLNSILVHSIIIGAFFIKIPQIIKIFVSKNASGISFVSIYLDIFVASSLIVLSIRDNINLKLYLDTLLILAQNLLILYFMWKYSNPYSKFIKIFKICLYIFYILFLIYGLPKAFLPFIGIISIPIGIFSKFPQIRLNKKNKHTGSLSPMTYLFLFLGNLSRMFVIFYNIKNKIYMINCAFSAVLNFTILFQVRAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDJ4</accession>
    <name>V7PDJ4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_05573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635824">
        <property type="protein sequence ID" value="ETB56428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDJ4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB56428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25940" checksum="1D3BF0DB57CE5302" modified="2014-02-19" version="1">MDEAVTFLQKYATITRNFCLYNRFENDVFLYFSKYSNPDVGKLEFKIPVPDAYEDIINLLWNPNGIHNFCSDFVSGKFVRVYDPSLAIMQHRYINNAQSTQGYVYFLAKKVDVSEDKTIIAMASANINDHNPSNKKYKNEIVKSANSFKIDIDSEDDIRNGNLIKMFINLSGFIIKKEDTHVDITHVDSIECNCPNVPWWYIQRAKAIKMLDFSKLQQLFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEG3</accession>
    <name>V7PEG3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="2">
        <location>
            <begin position="558"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1533" mass="181868" checksum="9834086AE346177D" modified="2014-02-19" version="1">MKNYILRNANKCISSLSGGVEKTYANSLISDIRGKYLFNRTIYTNNETYEDERGKKVCGNIIDDHKNICTERKNNVEQDEIYREKQNEFTKIFDENKFEKEDYSTVKIVNKNNTDTSEFLLNNENYLNFINKYNNNNNSSSSNSKGKGNRFSKNNLQIEDTEKSLWEILKEKEEELKNKKKLKLYKKELDKKANKEYEKIIKEEKYVNQQINDTHKFRTNDDKKKEEINNIEKKHKKKILKNNNIYNDIDTFLEGEHKYINDIKSYDEIYDENSKKINNKSVDEYKETKKNDDNDFCLNNIISEDMKRHVGNYNINDYSNKNKQIGSNILINDLNVKNKNCNQISNDNLLNNQLFVEELNDISAKKCIEKIIIKKEDKLVGNDEQNLIEINAAEIVKKIGGENLSTIVDGNIDNLIIQKEIKKEKNVTGLISVIYNNLDNCDNINLSTGLIKMSKIIDSYQKQSIMRNPMYLNIIKKVEENINTFELPSLVQIFYAFVKIDHLPYFFNDIINCINNKLDKAEPKHISSILYSISNILIETNESRILKMKVIDIVKNNIKKFNCLNDVICLLTSLSKLKYKDIYVYYELSKKIEENMNELNMKNVSNILWSFSNINYTSKLIKNMKKIIEKNINNTNYIDIINIIYSLVKLNEYDEHLFNDIFPNFINVYIHNMNMKNLCMILWSYTYANIDNPDLYINILTKINENIKDITTKDIISILTCLSRIKYNYRYKYLFTHLKNKIIKNLYSFTPLQLTNIIYYSSFLDLYDHKYYYLLVQQIYQIRKLLYLENLTTILYALKNVSYLNLHNIHVFNLISYIFDQIKIKYKLLTGEDCLNIMLIMNDLEKYTTQGYLTFSPHNNSANMTNNANIQNQEGDILLSNSFYENSKICEKNYIDIFEEGVSLEELHLDREEIYFPNINDLLYEQIKIRLNNFWQLNIKDVNNLLIIMKNVNTYDPVIINMIMRQIIPILLKCSNIEFLIFLSNITANTNLKFIALTHMSRRPKLLQVFKKKINSITSTILNNYEEPDYSYKNEFNMTFSNILEEKKRNLINNDTVFSKIEKKSDKDIAPYIVDKKTTNNDVSITSNISENAEKRITKNDDDNIEINDMYNSLSKKKNNVDLNSCIALCYACFNIHYEDDNILKMYDAIEHMITVEKKPISSFMLINFLYILTLTNNKLNTVIKLSQEYMDNRYGYNIEKKKKINNNNDNNNNNTNLKYQTQANTTINGNDKIMSEHTDKDKNDQNLKSLTSFNLIYEENDGLSNYIEIGNEQTSLILLKLLYINIILNKYNYLYHILCEISKYNDNFYSYEFIKISKQVCYHIYNFSNFFSKNKSIEYTWNKVINNVYVNDEHIFLDLNYEKTNFNFIDIKKNHNIINNLLNNPKIDQNIDNNITIAKYFYYILNYNLSDINNATPITSKKDKKKIKMFHFDNVISDILNFLNVQYKGSYTYENIYHICCSFPHERHLIDIIYYEVRIETYIVSRYVYLNIYVQMLLNLLYTSLLLYIIFMLFYSLRMFYTLRTNPCYLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEG4</accession>
    <name>V7PEG4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_04628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEG4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="754"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="820"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB57819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="859" mass="101685" checksum="ECDF15D91813AB8E" modified="2014-02-19" version="1">MSEYKIKSSYFSTKNKVILLICVFFFSCSTHIFKNVFPFLFMLTNSYGKDSNDHNVKIDINNNKTNKFYKQKNNNNVTRYPNKNYNYSDKYLNILEDKFDIDSGDMVRQNYKDGNGGNGENDENGENGENDENGENDENGQNGQNGQNNKISNHSIYLYSNVLTLIYISSLVTYVFILFFDLNKKKYILSSLYIINLISHCIIFLILNRIQISNKNVINKNGHNYKHMNIINSEHVLQKKNYYEFKRKEINLFFHVNLKNNFIHNFIEDYANLPYYNNKMNKTCFYNNMDEKQINDDIYNTKYFYLFYLFIIISSVCSAYIKIYQKNILYCIFYLNIGIITSLLILMNSIFKIMAHSLNYIMSNNNMNINISDYILMFSFIDMFGLFIIFVFSYKWSSQKKLWVNLSTIFYNYKYICFYINKTYYLYSTDKNIDNIIAQIDMCKDPNVDITFSAYINIEKSIFYDFFLKNKNEENKLNIIEIKDKNFKITTTYNTKNAQYNENDKSIFKDVENPNITPSYNRKKKHSHTIKPYKIHIETINKDLFEEMENLTNIEKEETDKIVINKSNSSNNVIPDTEDNKIPISSINNSINKGNGYSNCENLNDIHLFNDSSIKDKIEDVENKNSLNKNSLNKNSLNKNSLNVNVETNLNTNDNSNKSSNDFITNIKSKQPIIEDEFEKTINITEGEIEEKKNKFLVPNHNEDDKYIDYDNYDLSYKNYNSPLFIKRDKEIKNIQNNFIIFQNIKTIFSSFTFYFFFFIFIYAFLLSIMHIFVNYFFYIYLFVFNINIYISNIYTIIMTFVSLIAIPFSGYIIDNIGSFLFLLLCSSFFILIAISGTIYCCIFNLRKYHKVFISITLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEI1</accession>
    <name>V7PEI1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_04639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEI1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="94"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB57834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="243" mass="28718" checksum="8CE39F42190D1F04" modified="2014-02-19" version="1">MNNYFSFIIVTSLSVFLYICYLYCLQNDHLNNYSKFLRIFLALISAPLFVLYYWAFVKCSACNPGYVDDIWEINAEENNIQIENRKIRNYTPNKYTICDKCNYLVRPERAHHCRTCQRCVLKMDHHCPWIGTCVGEKNLKFFFLFLIYGLFISLFVNITIMPQFVKSIYETDEAKESYKMHHAAIFISVSATTTLALALIFMVFRYIYFISHNITTIESSYADKNPYDIGTYSNWKEVLHLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFM1</accession>
    <name>V7PFM1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFM1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="294" mass="34086" checksum="5803E4D5CDA4BB8F" modified="2014-02-19" version="1">MSRVCIITGGTGLLGNSFREVVKNENPNFIESENEIIVNSNDKNVIKKYVFLSSKMCNLKNYDDTKNFFEKNKFTDIIHFAAHVGGLYANKNNNLQFLLNNLDINLNIVKICHKYSITRGIFALSTCIFPEKCDLPLIEENVHDGRCHLSNEGYSTSKRVLEILVRCYREKYNYQWMCIIPTNIYGKYDNFNLENGHVIPSIIHKIYLAKVNNTDVKLMGNGSAIRQFIYNRDISNILYYILNTYYSQNLTIIKNNIFNVIFSTNLPSNELSIKELANKIKHYMKFNNEILVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFM6</accession>
    <name>V7PFM6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_04614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFM6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000005">
        <property type="entry name" value="SnoRNA binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="294"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB57800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="503" mass="58062" checksum="440AAD4C976C352F" modified="2014-02-19" version="1">MKSLYILFECSAGYFLLKVEEWEQIGNNENLEKKILNPDIFHQIVKFCAFIPFEIAETALDNLLNINEGKATSFLLNFLEQNLPNNKSQYELGVADLNLGKFLSNIGFNIVHNNNILELFRACRLFYLKKIKNYINNADIDIKNFNIGLGHSYSRSKLKLDPRKQDKSIINSIGTIESLDKNINVFSMRVIEWYSWHFPELRKIVTDVCMYCKLVILIQIKENFDFENNKDKINEITQNEEMTENIEKVANLSIGQELAEEDLNNIINFANEVINLSNTRNVLWNYLDKKLDIVSPNLKELLGNTLSARLISHAGSLVNLAKCPSSSIQIFGSEKALFNSLKGNKKTPKFGILYNSSYISKTPTALKGRMSRYLSCKSAMAARIDSFSDYPTNSYGIAFKKQLEHKILHMIKGVKLSKNIDYINEAEKIYKNQNGISNVEDADDDEEKKRLKKAKKEEKKRRKLEKKMKKEKEKAEKESEQNQDEKKESEDNHDEKQNEGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFM7</accession>
    <name>V7PFM7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFM7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="289" mass="33475" checksum="B73E57E9C4FCF708" modified="2014-02-19" version="1">MSRVCIITGGTGLLGNSFREVVKNENPNFIESENEIIVNSNDKNVIKKYVFLSSKMCNLKNYDDTKNFFEKNKFTDIIHFAAHVGGLYANKNNNLQFLLNNLDINLNIVKICHKYSITRGIFALSTCIFPEKCDLPLIEENVHDGRCHLSNEGYSTSKRVLEILVRCYREKYNYQWMCIIPTNIYGKYDNFNLENGHVIPSIIHKIYLAKVNNTDVKLMGNGSAIRQFIYNRDISNILYYILNTYYSQNLTIIKNNIFNVIFSTNLPSNGNHNIYLLIFIVIVFQIIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFN8</accession>
    <name>V7PFN8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_03992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PFN8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="8">
        <location>
            <begin position="479"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="7">
        <location>
            <begin position="875"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="777"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB58381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1262" mass="146955" checksum="7CC7D15DD4875CDF" modified="2014-02-19" version="1">MSNVFDKLRKQRSKECKATDFYEVKNKNDDIYEVVDEDGYIENKNSLKSFIVGDDKNYDSSDDVILETVDYSMITKKNAEKESKPKRNTQIDDFIREKKIQKIFSSGKLTKDDISKTRNIEKMMENNSSSSDSEGRCGKINIKRKTRDSYDSYYYNNSSNNSKNKNIYDRINSQPRKSQENYDIYDKIGKDNIGNANLINNKKTNNFFNSDAEQNEENNENSDKKRKIEIENNEPNKIVKTINSNNNFKDNIKQEEDVLTMNKNLSSLNKNIKNDNILKDLDGLDIRIEIDEEHKLDAVNLKNENLDKENEDSGDEKNNVNDSILKNKYEEIIINEDTGYVNIYVFDICKHKNSIILFGRTLTKLKRYKSISIYIEDMDRCYYFLLNKNKKYVKDGIEITYGHEKYKNFIMLDFVSEFKKIREYHNIKMAKYKIVFRKNLNLSSNNEELYAKVLYSYNYDNISEQFSKGDTYSSFYCCNDDIVENFIIKKNMKMPCWVKIKDLKNNFSNNIAYCYFDCTVASKKNIFTLDKFMEKKNTDLINGSNHNPTTNSTNSGIIHDESLKKIDNNNLNNFIDIDLNKLVIRVVSVLNEENNHEIFSICSLVDADGMKYINFFGICVKSNKKGSTPNISNNINDNKNEIYSYNRNNCKIFPNEKLLLQAFLNKIRTIDVDIYIGYNILNFDLEFLIHRCHVNNIDPGVLSRKKKLKKSDKMKVNKFSGTNSTGSIYNIVQNIKGRLILDIYALSKDTIKLTSYSMDEIIDGVRTKFQEKVKQQTGSNSVINGNNNSNNHTNKNKSRENIQNVFKDFIVNDINLINCNNIHLFDSEQILENHLNTYINSQIFSIYEIYNVCNVLQLVEKSRDLTKLSGYIWARSLLSYTSECVEYFLLHEYHKKKYITPLVAKKKTKIENDSNKSKNTAKYLGGLVLEPLCGYYDTYVLYLDFNSLYPSIIIEYNICFSTFNMKNYLALSGSTSEEIQEETGKRNIIDYNDSDVNNLDKDDQVGDISNIDYFDKTKPGILPSILKQLVEKRAFIKKLIASEKNKEKKELLLVQSLSIKLISNSIYGCLGNTHNRFYAKYIASYITQKGRNLLQHTKFKVEKEFNLKVVYGDTDSIMIDTGIKSSDVNNYKESLKLAHTIKNNINKNYKKLELDLECIFSKLLLLKKKKYACAKVIDPNLGKYEYEMKGINFIKRDFCKISKLIGNEMLRIIFSNKEYKPSQPNSSNTSLSHTDDLSIQNDLSEQIHEYLRSVYQRIQNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PFP0</accession>
    <name>V7PFP0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="801"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="871"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="801"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="871"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="772"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1065"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1462"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1826"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1325"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="772"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1462"/>
            <end position="1477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB58244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1970" mass="228469" checksum="4DF17C03D228A18D" modified="2014-02-19" version="1">MEVATEGGSFEKLQFKKCEDKYILDQHLRTCFSYLLLYIIKECYYIYKIKCYIIQNALKIYNSQSKSSILNNYKTLSYLLYSQKWDNNIIYDIINNSNYFCNYFELFNGENYFTEDIHKTNKIKYLPNPYESVKNSINLKEQNKYEEIPPYIQFDNTTIRGVTIHHNLENEFSQILNGIKPFLSTNENPNNKKRKTKNKTIATININEKNQILRIKNLKNIQTTENSFINNKNQPNKMNAIIDTGNYFSKTFISSFQNDINKTDTDIFNESIYEYGQNSKYLQHIQREILNNNIVKDGISIFEYKTLHNIDHVNKFSRNCEYRDNSNLNNDAGQNNNGKNENGGDKEKEINNNDNSNNSEKDNSNNNQDKNNDQNQGGGEQNGEKEGDGKENDNNNDDNDDNNDDNNDENDDNNDDNDDNDDNDDGDNGEKAKEISEKEKYKFFYKKIKEIKSNIFVKRCKNVEKYFKKKIFNYINKNNIICNMNIDTIFIYLKNIYYLILNNKQLVFFFIYNTNDVMTAIINTEKCNEINYSEKKFFLYLLTNEKEIYKKIFDEINLKYDKNELILKLKKLKKKLNDLKHTEETNLFEESMKQLGLFKDIKKCVNSNNSNSQNNISNDDIYKLFNYTNKKFLKNYKGVSHKLSLKNLLPKLYNCKDLKETNNLICNVGKNVKSVTKSGGGVGCDGKKKKKNKKNKEANMKKNNMNNYMTNLNSHYNNFMNNNIDKSQINNSFNYFVNFQNNNGQSNNNVNNYSRFYNNMQYAQHMQHSVNFKDNNLNDKNGNKNNETDEKGDENEVKKKAIRGITSFTLFAREKRKELLNQKVFLGSSLTEQTSAVAKIWNNLSDEKKKEWAVKASKINEENFLLQKKKKKRKFTAFSIFAREKRKEYKEKNIDMGLTLAQQNSYVSKLWKQLSNEEKNRYKYLSNTVNAAVAKNNKNQVNYINGQKVSGFKGRIKALDNMMSQHFSNNNNLMYNDMSNFNNNNINNSSNSNNKMVYNPNQVMMGTENNSYNMNYMANMQNMQNMQNMQNIAQGDNNMNYFNYMENMNKNITMGYMNNDMNMIHDNGDDKNKKNSLKKNKKKKNENFNDPNQLMNNPNYMLKNANSFNQQNYNSLPYHNDGLNNTNNYYPLTFPNDNNDEMNNNNTINNNSELYRNIVINNNTQNLITENNQNVMINNMYDQNQISINANNIVNTTTQITNMKNNMTINSDVPMINNTKGDHNISINPIDNNELIQGHANVYITNGLNDNPGISNKINFPLHGHSEFSYNKYPNETNEIYEHDNVNIGGTSNGQTNMVMHNYQVINGNQKKGTKIDDILKKKMMKDEKKKLKEEKMMLKEFDKRRKQLLKAEKLMEKNKNKKMSNSDNNGIAAIDSNSGYYDPASVMNNNNNNNNNSNNNNNNNNMGMYMNMNNYDISNPLINNPMINNYNFYANPDKKNINPLNNNNINIVNNAPSSISTRNNTNNTNNNSGIISAPTDEGNNDDHLSNKGLINFKHVINGNGQNISNDDEFSNYTYGNKFMTDSGGVIRNNNSIPNDTNIQISDDIKKYDHVINNNIHDNTKLGNHISDHQHISNDQIQNPEINSSVINSNIPDGLNHPTYLNSNKEYYNNTNYFNNVISNDQVMFQHTNGTSNVVNNGVPIKYLIENGSNSNKIYGYNNNNNNNYLNNINPNERTANGISGGSNNNTGIIIKNDEYFNTIAREKENNNNNNNELKVDQTFNNTNYYQKNGTNKYTNRNNTNVIVGSVNNNNNNNKINNSISYDPDDNNHTYSNITNTSAHLHNSKQHNQSQYINLNETINNDMNMGINMEYNNGMNYININNNDNNSNNNNNNNNNKNNNKNNNTSYFYPHNRNNNVPNNNFLPKTNENNTTALNCMANGDNIMYFPDHVVSENNKIPGNLVYFDSDMNRISGRMEDIEINGHKRKQQFFNNASHFLELVDKKIIKRKKKKSSSLNIVNGINKVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7PG10</accession>
    <name>V7PG10_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Exonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_04723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PG10"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004763989" description="Exonuclease" evidence="6">
        <location>
            <begin position="22"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="60"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB57935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="73503" checksum="DBE464A593457172" modified="2014-02-19" version="1">MILFIGLIIWLINEMIYSVCGIKNMYYIKPITGNMDILNIKKSKFPNRKEKNKEYNKLYGIPRMYKWLTSYYPTVREELINEGEKKKVDIFYIDMNGVIHHCTHANKDALPIHDEHELFSNILHYLKNLFYLIKPQKLVYIGVDGVSPKAKMNQQRKRRFLSLFKISDNSKTTNLFNPNCITTGTDFMYKINLSLNKWFKILKKKKVFNFDIIYSGSDVPGEGEHKILKFIREKCKNDSSFKNWNHCIYGLDADLIMLSLVTHLNNIFILRDKFKLTNDSIHNNVVDNIEKMQSEFNVNSESDSGEVDSSEREVTINSESKNITINSESKEIDKSEENKNVTNNESLNNCFNKTHKYTHDYYLHYDELNSYDFEILDIYKLRSSIKTQIATYINKLKKEKNIIFSINRVVDDIVFLSFLVGNDFLPHIPNIDINEGSMNEIFNSYIFYIYKYSNYITYKDKVHIERLKIVLKILSGQEFQYFKKRGINENIPEFTDEKKYKSYYYFHKFGVSDSKEIQQIVKKYIEGLFWNLHYYHFGCASWHWEYPYHYAPLCSDLLSFEKSDFFFEKGKPYSAYTHLISVLPQKDKNLLPDPYKNVYAEDEVKSFFPDNVKIDPNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGK3</accession>
    <name>V7PGK3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGK3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="22195" checksum="2CB7DDF888AF4A92" modified="2014-02-19" version="1">MPDNLELLHFYNIYNDRRNKWKIGINKLNLNIENYKNMKTKIFLYVLWSILLFIYFFEFLLNLLFLKYIQNINIIIKIIFIFSISEFITIILLTTQSIYGYLYDSSLILQKASQSFFILSVWCFIKLLFYIILIILLSAFLNSNIILNTQLLYFSNQTLYFNYLIKLIITITAVKFVLTFFTGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGL3</accession>
    <name>V7PGL3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCIF1 WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_03828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGL3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016422">
        <property type="term" value="F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039881">
        <property type="entry name" value="PCIF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022035">
        <property type="entry name" value="PCIF1_WW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727:SF0">
        <property type="entry name" value="MRNA (2'-O-METHYLADENOSINE-N(6)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727">
        <property type="entry name" value="PHOSPHORYLATED CTD INTERACTING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12237">
        <property type="entry name" value="PCIF1_WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="PCIF1 WW" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB58681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1274" mass="157043" checksum="40E5CB0B5BF4B2BE" modified="2014-02-19" version="1">MENLYDLNNIHKEYDLQKKIIELRKAFINIYNFKTFYGEMLKLKNSYPRDINKKIDKLWIEYKKEYFIKQYKDGIIFYELNKNLCFLEKEIINRYLFNFNICNSNYIVQEEDVYLYFVFYRFCSMCINNWERKNVIKKGDKKKKIYKGQNFLNNFWIDKFLKIIIKIDPNYYKKNIYFQSIKDELKKYISSENCLMKIQYKNQRVEKPHNYYFVCISNSCKKREIEKDRNISNYKNWRQYYYKVKYHTHNNMSINRVINKKVNSNILIYNNYKKKNLIIDVEKTKRLIQKYIYNDLYFNVIHSIYHSLINKNADLITDYVYKEILLDIENLKNEEEKYDYSKASYLLIIDKLKKYEHVQKKNRHDLYNENIMDNFLVVFKAFFIPFFTYEKYVNNKIKSNDIFLFNYIKCILRENIENMFYLTIVNINKIYEHMTFKYLFYLFFLYFIMLDISPCFCISHIIFNDKLRGNEKQIYKYFLIKYRKKNEEKKEKKNEEKKEKKKEKKKEKKNEKKNEKNEKKICPEKKLCRDPPNNDYNEMVDKPIYIVCFFCSYNLLKNDKNIDLEMKKKMLILLVMNIVQVHYTQTDNEIKIMKEMDLLNIKKRQFSFLCSYFDIFINYLFFSEKCNLSFAKLGNVKRCYTYTKTHSCYFIKNKNKIKNNFKQNLKKMNKKCVYLAYFNKAINMKDEKIINNYTEETKIDGAIYTSENNLYEHVNEKIKIFLENFKTFLFYFLDKLYRTSIMHINLYTYLFMIRSSLLLSCKNYENTRDIQKIKEEKIFKYNRKITNIRKRKRYRGRIKFLNTFYRKIYLHTYYKLLNIICNDEEKKKILQKFKIKINKLLLYLKKNIFTYNIHNLQILFKLQNIINVYKHNYIKKKYISLSKKNIINNIDDVEKESCYIIYSRIKLFATLYFFFFKKRINISLENRQNKIDRECWHNLIANRNIINNKNDCILEKYINIVYKNINILFPNIYIHINNNDFYIQAKKDFIFFNLKNKDKDNNLWKENIYYEFHGKKYIVFENMYNLKKVYKIKYINLCILFHRYCFFFYNYNPFIFSYLFKHIYCMCIECVQKYLIIDNCCIKKDKITEKNNHDCFYKQNGILIKNRNHMFVQNFYYLTLFLLIRYHTLLGNARHSGLQSCIPKRIMTLLYKKLKVDRECFSSPFNAILQKYCSFFPDIDIFFGSAGNFFNFNFQNGAYEINPPFDIFLINKLIVYILYNLKKEEYELTFFLIIPLIKDKNYFYELLFSSPYLSSFFLLKNGLYTFSTRLFETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGN5</accession>
    <name>V7PGN5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_03768</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGN5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB58589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="341" mass="39764" checksum="3715F7272060FB43" modified="2014-02-19" version="1">MCVYISLIYIFFSLYIVVRSFKKHYFEDKDPMHIAAIKSLESSLKSSNTKTNFEYFMKLNEAKSQLNNYIKNENVKNQIILTPHSKRMTIYTIVTACDIYHHFAVKKYTHNENNFDDLKSISSKCASEFPKTLQNSLDMIAKNSCTLFGSGKTKILTFSSSDCVKALLLNVAKNKKIKICVYFTCPENCNNNNYLEKDKFFDNKFINDLKNENIDVIKINIQEIQNIFEIIDFVIIGTELVIDNGGIITKKGIKLISELCLLNKKELFVLCEAYKFLKIKTIQNYDEHFYYYCTKNIANKNNFLYEFVPHNFITLFYTDIGIFPPSTISFELNKLYINDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHP7</accession>
    <name>V7PHP7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_03936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHP7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="405"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="499"/>
            <end position="503"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB58302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="769" mass="92015" checksum="5BF41C54D81D8E94" modified="2014-02-19" version="1">MKEKPFNETFNKLKKNEEWLLQDSRIIYFLEKIIIFILNIFNKYNNETDEINITHKLTKIENGKSEIKIPFLLFKNENYEETFLIKFYSSFPFKIIIYSIIMLFISVIYFLILYYILLKNMLYNEYNIIFFYTIFKFILDIFYFTFFVIYTFLFNTNCIDKIATYSYKSCYLFISLIFIHNIVLLHFNSSSFSLPSNNLVKYINKYTYKNYAILLNNVYMCIFCFLRNYIILYNFLLNLKFSIFFIIIIIFLPLYAFFFYPNLQNDIYISTFIFPLFCVLVIVISLYIQYKYELNKRITCIDMNEDIKKVHSNYITKYFSIDNSIPTSPIEDILTNLKSILDYTKNLEEDEEGNDNKLIEINKIQEKIKTCENILRTQNLNEVPVCKYRKFEKVYNMWCLDQSEKNDEINSFLSQHPNKKSVTSFFNMHSLLSAKFQDQYNDIYDWNADIELIYKRNIFISIGYKLLYPLGVLETNFNNEKLKNFLLKIYSLYNDLPYHNSFHAAQVAHFTKSMLFMLDLNKKISGIDEFCLHVSSLCHDVGHPGLNNFFLIKSENELALTYNDSNVLENYHCSLVFKTLKDPNCNIFANYPNNIFITCKKNIIRAILSTDMKNHFEYISTFRTNREFIDYENLSNEQLWQIFCLILKGSDIGHSTLEWKKHLEWTLKINEEFYLQGLLEKSLNMSKSFLCDTISIDKLAISQIDFLKHLCIPLFNELNYISKNNEVYNNCISAIENNIEQWEKNKNNQKNLGLQEKYQDDHTVEKIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHQ2</accession>
    <name>V7PHQ2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHQ2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="1">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="412" mass="48775" checksum="10067DFF2F41DEEF" modified="2014-02-19" version="1">MINKAIKKLVSKNFLCFTSRQKQNKIINHNKNIISINVSGIRNVSNIRNVSNVGSGLFDGIPNEEIDKDKLIYLVKNMQMVNLKEKGILNNISNLLKRHMNQFTIDEIYLIIHSFSKLDFRKYSLYNNFVKIIMTKKPVINTRTLTQMLIDLHKTSSLDLNALTFFTQYYINNLVKNFSLFDLSMILYIFNKYNYNDFITVNKICQTISDHFIPIIDEDKARGSVKDKFLSELLKDIVFLLINNMQKLKNDELKQLHIVLYFLRAIEENYEDTIKKIEKKNIKNTITVSKMQHQVEKIFTEIGLNVNKEFPVGPYVLDFALKKKKIYVEVNGFTHYYTFDGKINNKTNLKYFILNKLKWKVIVSTFFLKKKYLKEDKVFFEICTQRYFIILFCTQIVTIEYMDWKNKSKDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHR3</accession>
    <name>V7PHR3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_03950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHR3"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB58322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="447" mass="53442" checksum="0FFA088388252A3F" modified="2014-02-19" version="1">MGNSITEKRSKIFKQNKSYFSDINNIDYTKKIIYFLGILVRIITYYYGLWQDKNLNVKFTDIDYYVFSDAAKYVLNNKSPYNRYTYRYTPLLAYLMIPNFIINFSFGKFLFSSIDFLVSIIIIKIIKIKYPENKNYILYASLWLLNPLVITISIRGNADCIPCLLVLLTVFFIYQKKIYVSAFFYGLSVNFKIYPIIYSLPLMLYLNKNYLNKDNIFQLKQIKTEGIYINKIIRIFYIIRNFFKELFKLNTDQLKFSLFSFTTFLALNLIFYAIYGYEFLYESFIYHLVRQDHKHNFSLFFYIMYLTIENNSKIIPLITFIPQFVLVALFGFKYAKSNLELSMFLQTLSFIALNKVITSQYFIWCTPFLPIILNSITLNRVTKTKSEQTNLILIFCAVLFFVIAKAHWLFWAYFLEFKGYNTFIQVYHFNTFSLDHQTYIIKTKVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHR8</accession>
    <name>V7PHR8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_03950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHR8"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB58327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="398" mass="47408" checksum="F01400DA70552B1F" modified="2014-02-19" version="1">MGNSITEKRSKIFKQNKSYFSDINNIDYTKKIIYFLGILVRIITYYYGLWQDKNLNVKFTDIDYYVFSDAAKYVLNNKSPYNRYTYRYTPLLAYLMIPNFIINFSFGKFLFSSIDFLVSIIIIKIIKIKYPENKNYILYASLWLLNPLVITISIRGNADCIPCLLVLLTVFFIYQKKIYVSAFFYGLSVNFKIYPIIYSLPLMLYLNKNYLNKDNIFQLKQIKTEGIYINKIIRIFYIIRNFFKELFKLNTDQLKFSLFSFTTFLALNLIFYAIYGYEFLYESFIYHLVRQDHKHNFSLFFYIMYLTIENNSKIIPLITFIPQFVLVALFGFKYAKSNLELSMFLQTLSFIALNKVITSQYFIWCTPFLPIILNSITLNRTNLILIFCAVLFFVIAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>V7PHS4</accession>
    <name>V7PHS4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Minichromosome maintenance 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">YYC_03955</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PHS4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000007">
        <property type="entry name" value="DNA helicase MCM8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF47">
        <property type="entry name" value="DNA HELICASE MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="15">
        <location>
            <begin position="536"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETB58337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="955" mass="111601" checksum="2DBD77819A2EF533" modified="2014-02-19" version="1">MHIYKMDKIVQLYFNKLELNDEVKKLILSWVKFFNKNWEYLFSIDKDVILNFEFFLDNKKIINKNAPPNNEIFLHELKKNPEIVLKFMKVAIHLLLYHGLGINEIEDEDQIFKEKNISHKKHKNMRETEKRINDDVENNIFYKENESKIKSFIQNEEVEKVKSNNILLNDLKYDRYKDSEIFRTYFFSTQITIYLYNWNKINKFKNLKSEKVNQLVCLRGSVLRISPIQLLITKIDFICEKCKYIFKIEFIDGKFEIPKKCLIKNCDSKNFAPIRESAKSIEYQKIILKENKKNTSNIYETDNTSNIKNLLVTVEVSKFFVNTCLPGNYVEVLGILKVISHINNYLINGKNSIFNMYIDCISIFSLSSKKYYNNNTFNIQKIKNEKKKIYSTLLWQSYIDNVEKNKSNNLELQNNNNNNNCSTNLTNINEKDLHMNQNYDEINIDDKEYKIDKNKKKNDNFFRNEESIPTLNMYGDFLDMFDINNNYLNNDYINKVANSIDKENESHHNNLANPLIDFDKNTLNFIKDFEKYKNNKFYLLVSSFCPRVVMNYYIKAGLLLSLLGGKTIYDQFGEIKRRGNIHLLLIGDPGLGKSRILQYISNIIEKSLFICSTSTSINGLTASAVKDSTNNEYSLEGGALVLSDKGICCIDELDKISLKDQQSFLECMESQCINISKAGIVCNLKTRCTIIAASNPKEGKYNYNKTIFDNIKIPLPLLSRFDMVFLLADKISEEKDMHISNYLITSTNDTRKNSYLHDQNEKNNFENIRCNDDSTFVEKDDNFDESIFFDFQYNLTNKCKQIDESNYLPIELLGIFIKYCRKSLFPILSNEAKQYIKKFYIHLRNASIAHNNISIPITIRQLESLIRLCQARARADLSNIVTLEHAKEVVVIYQKTIFYPLSLKVMDFKEKKNNKASRGKSAKALSGLFKKDIIKIAQISGNKINNKVCNVENII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI18</accession>
    <name>V7PI18_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CMGC/GSK protein kinase, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_03437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PI18"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="62"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB59186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="432" mass="49979" checksum="A3001F37208BC424" modified="2014-02-19" version="1">MKDWHTDDDNNACQENEQTNNGIDNKRDDDNNYTSIEVNNVCIEEDQQIGENEISKSSNKTYKLGNIIGNGSFGVVYEATCIETSEKVAIKKVLQDPQYKNRELMIMKNLNHLNIIYLKDYYYTEAIKKNEKNVFLNVVMEYIPQTVHKYMKYYLRNNQFLPIFLVKLYSYQLCRALGYLHSKLICHRDLKPQNLLIDPKTHTLKLCDFGSAKSLISGQRSVSYICSRFYRAPELMLGSTNYTTHIDLWSLGCIIAEMVLGYPIFSGQSSVDQLVRIIQILGTPTEDQMKVMNPNYADVKFPNVKPKDLKKVFPKGTPIDAINFVSQFLKYEPLKRLNALEALADPFFDEIRDPNVKLPKYVEKLPELFNFSVEEIKEMSDLCRKKVLPKKNYENCQELNSPELNNKHLNGSKEINMEDGISNVNSCFTIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI23</accession>
    <name>V7PI23_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PI23"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="238" mass="27687" checksum="0C2F732F3DDC3FFF" modified="2014-02-19" version="1">MINFSNTLVILNNDVPCELLKKKYSELLIPTISILDFKKKKIYKKYNNIFLYSYQNYSFLLDLNDNILLKIQKYLNKNGILDINLYLNDKNNNSNNRGTNKKDHSKIEDISQILKKLRKECLYNGYINISTEQTTSENGIVINIKAENPDFNKSDDDNNLVSSDEEIYEKCEDKKKVVNRVCDNCTCGKKEKAMNLEKIKINDNEVEYSTENVVSSCGNVRRKNKQITRKIIIISTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI30</accession>
    <name>V7PI30_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PI30"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="602" mass="72510" checksum="834F270038044C9A" modified="2014-02-19" version="1">MPFKSYSVFLLYIILFHVLNVICLINKNLFFITNPPKSISHFSRIKSKDIRFKKKIFVKVPFRGIRQKLLLFDKLKNGFFFFKYIQPGKNEKFWESILMNLNEITKVKELVKTTKDIRLEKDDIEKIFQHAILSKINFKIINTISYLIKHFKIDRNTISSVLDIVSKQIKDPKSAEHFLSLYSFLLEDDIALFSIMHIVDFFKSKHKVLETLQNIKAQIYDECANDLVRKKIERYNIFCEKENIKYNLEDGLKKIKLNIQEDDIYFNYDYKYLLKIFEKKTKRYDNIGTVKDEVHIMSDQGKIDEYIDIENHDCLKELKKTYEKLQSFNDSIIEHIESDQDLFYFNDNEHMANKRKKKNINKYEQNNNINETEEDEDEDTIAMQKNIDDYIEKYKRDNNSSVEHLKNIFVEQADIDLKNFLETINLDNNIREENETNMKTLRKSNKHTIENFEGLYENNQNKSREEITNFRLKQLNQSDEALNITNDIFYERMRIKLLYYIQKIEYMKYKHQYEILNERYPINKSEKTILDLLKYGYKIDVSPDVDNSMFKKNVNIEKDKMVDGHHPIISFKQKKYYDFKCPDCGYHIFNTSNPTFFIIYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI34</accession>
    <name>V7PI34_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vesicle transport v-SNARE N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PI34"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="21788" checksum="842BDC04F128AAE5" modified="2014-02-19" version="1">MFLFYLLIFPFDFSILSFDFSIFYFFTTTDLNQIKQITVETNSLPKGSHKIFEQINKYNSDLKKYKNILEKMNGDYYSEVTDREYDLTKKYIEGTNFLDESERRAQDVEDMGYTIMSELTSQRTTLLKTKRHVDETRQEQSRIKRIMLSIYNNKIIYKYLLIVIIILLAIANVGVIIYKIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PI42</accession>
    <name>V7PI42_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein axonemal light chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_03825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain LC1-type family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PI42"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000049">
        <property type="entry name" value="Dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB58675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="169" mass="19600" checksum="6647E5DC9552C50B" modified="2014-02-19" version="1">MNRVVKEVTISQCIKNWEHKTGKKISEEENVSFICNIPLIEKLDQSINTLEKCKRLSLSTNRIEKFVPMSGLKNIEILSIGRNCIKKLQFLEDISGTLKQLWISYNNIDKLDNLQSLKNLQVLYLFHNKIKCLEEIDKLNTLPELIELGLKGNPIYEGRTNVRKVSTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIQ1</accession>
    <name>V7PIQ1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIQ1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19415" checksum="0D125FF7DDFE96D8" modified="2014-02-19" version="1">MIYNHHFIGIFFLVLFFFKVYNCLYVTDGSAIILENTGTKYKLFSTDMKWGTGSGNQIVTTITSNKNDEELLWIVNLYEEGKSMMGNKIQCDEIVTLKHVKSNGYLIGSQHYSILSNNFELSIDKDNSFGRFQVICENKKGGSYWMLGENVYLKSLNQNGYLSTSKKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIR5</accession>
    <name>V7PIR5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Partial cleavage stimulation factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIR5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031721">
        <property type="entry name" value="Partial_CstF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15861">
        <property type="entry name" value="partial_CstF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Partial cleavage stimulation factor" evidence="2">
        <location>
            <begin position="420"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="486" mass="55790" checksum="F4A0AFD3FD31C9B1" modified="2014-02-19" version="1">MNMYDIILIINKLQELIRACPETAIHMLNGNKKIYYAFIHTLFLLGILNIDANKLNDEELILSNFYKIKNKLQYLFLNKKENHEINNIVEEDITFEKQINKNCNKQNKLYNYHEENYHEENYPNALYNFIKKKRNDNYKKQNEYGLYLNDKKKMKTGETAKEEETGNKISEKISEKISEKTDALNNIQEYENGYSEVNGLIPNSYGNVLYSFISTTSNKTNPNENGYVENKIQYNKTDTNKSGLYGKGLYGSNNKNKNKKVENDINSGQPYYNIDVENDGNANVGNTSSANVGNTSSGNVGKNRSNNVESTNVESNIVESNGVWSNSGRGGDASNFGSNKNDSRVKGFDFGKNLIKKINTSNNQRRGIKLIDRTSNGDNVEENVIKIKNVYNIQEEINKKDKHQKKNIENNTNLKKVLEKINLTINEIPEAEEQLIKEVINQKDILQNILASKYQDMLKWNNEQTLRVLSLRKSLKKKGYKITGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIR6</accession>
    <name>V7PIR6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_02937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIR6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB59456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="219" mass="25194" checksum="88E2468CB2887E4A" modified="2014-02-19" version="1">MGISRDGRHKLRLTGGKKKIHKKKRKYELGRPPSNTKLGSRQVHVVRGRGRNYKYRAIKLDSGSFSWPAFGISKMTRIIDVVYNASNNELVRTKTLVKNCIVLIDSHPFTAWYENTFGVTLGKKKKSKEEEGKEEENNEEQKEENNEDKDEKDKKSYSVIKKIGKAKQIDPALLEQFKQGRVLACISSRPGQCGKADGYIIEGDELLFYKRKMDKKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ07</accession>
    <name>V7PJ07_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_02994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF3">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="11"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="695"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1572"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB59541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1971" mass="231618" checksum="B59B6463D0CCFCF8" modified="2014-02-19" version="1">MPVAYIEKFTKLQDMMPTSPFEKIEIILKRELGSMYEFFEYIDKTPLASASIGQVHKARLKKGIVIDNMNKSYKNDYNVIIKIQHEGIDKFLSSDISTLKKVSWAFGLIDKNFNFGDYIEEWQNSASRELNYNYEVYHQLLAYNTYKKSSIDLKIPKIYCAYTTSKVLVMEYIKGFKITDTKYIKKYNINTYDLIYRIIDYFAYQIHSDGFFHGDPHPGNILVMLKRDCNKNKISRYNKYLKKKKKKKKYYGINELNNQNRILNYSENEFRSISNYDNKINKYVKGHSLGNESCASMEEFISSRYNITKLKSGINKSQNFYSKTCSSSGIRKKRKKDITDKVLREDYKYLINNDDKTNENGMSKNKGGQESTITSNKDASKLDNSGSYIKSDSKILKITKNRNNGILNFLWKNQSEANKNGGGQNEGDKNESDKNEGDQNEGGQNEGDPNEGGQNEGGQNEGDQNEGDPNEGCVTSGELDDGMIKEKDNNLSKKSDKNDLKKKEKRKKRSYECVPVIIDWGLIKQLDNVMKLAFCKLVYNINCMNFLNIIEAFEDMGFCFNDDFTYDPEIYIENLKKFFLKKFEESEIKSKENESSINNNGKENNISFLKNIDKNDVIEKSPISDVPKDIIFFLRVASLLHGLCTQMNVKINYLSIFSKRAKEALENIYKPIDTSIYITPISKKPKTFLEKRIHNFIKKLYEKEKILGCQICIIHKRKVVVDTCVGMMGIIDKRPITRHSLFNGYSLNKLILNIALIHLIYNKTNDKINSEKERYKNSEKEKIKKFKQKLNSPISNYLDGFICNNKKYITIKDLLTLKCFIRKPFHENITLNKFINYDSMINMIENAKNYNVKNRSKKYGEYMYLIDTYIISELIYNISGLKYHEYIYRNIIKPLNLEEDIFIPLPSYFLKSFNDKNKHENKKIVSGIGSSNNFVNNSSHLIKDNEFDRHNDENDSISNYKTSYIESYYNSKDNENKNNNNFSNFRKKKNEYKNKKPFLNYKDNSNILENEDASNNNKFKNKKMNKIYNLSNNVFENKFINISNYNYKINKNNILKNKKFIKNLNRSLSVDVYYLKKKNIDIKKKVKCESIEKTKLLSLNHSQYSYSDINDNTNVKSDKFDKPDKFDKSDKFDKPDKFDKSDKFDKSDKFDKLQSFKDSEKKKNNKENFYDAKDDITEDNINNRCNDKIKNNIKQKDIFSLKHTFLNHVDNLKEKTKKINDSIKNIYENNDNIFLKNLFTSQKKAEKGEKYNNSHFDNSTHFDSSANFDNNNDLEKDYDIRNIEYKRLYEKKKLKKNKKSDIFFENILKNGKINNVDKILNINKLKSPLKILEKNKKKINIRNNSNRRSLSYNNIDHENNLFKNLESINDTNHDCNQNMPKFTNENDENDENDENKKGKLDYNKNSQNELIPSIFINNIILESKVDKGGNIEPVSIKDVNIESATVKDGNREPVAIQNGGERKSGEYLNINKNAKKLYKQIASENSSDESVNSTLKENYNNYQKKKNMKYKKLYKYITELKEYIRDKEEKLENIKKNEFEYSNSFIFENDNSDNLFKINQENYNKNGGSNYQANSNNDIKKKEEEYEIMKKELSKEKNLLKKLIDYKYLIIKKQIENINKKKTKKMIYNNSHTDEYDMFSDTEYSSTDGYTNYFLNKDDLKIKDRNINEKIKKLETYLIMKKTYKKNNDGHIPEIHHTINKNTQVYWKLVCSKRNETIAEKLSENGNLKNNFDNILNTNLKKSKKKINTDNGSDDIQKNNEINNLKKENDNNVTNLNKTNKQDEKIEPKFKSYLNHFNSKQCNKYISFFQLAKNKPYVLDPLIYDSKKILDKFIPINGRFTAKALTKILAYTNENIFFPSKIMNKMRKEYTIEKSIESFILTGGMSRKWGLGFQIFECEYDGEINEEFLIKKKKRYTNRQVDKCTKRIVGYGQSDCSGCFTLSFPEINLSITLLLSDLYKGAEVRKYKHCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ09</accession>
    <name>V7PJ09_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635789">
        <property type="protein sequence ID" value="ETB58288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJ09"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="577"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1275" mass="147332" checksum="D5714A23F57422EA" modified="2014-02-19" version="1">MEYIGNIYDKVLSGYVSAHVLKYKSWEEKLIGKEACKNDSDYIKQNLEEILGTFVKNGKFSHSLWEQHKMFIGDEGIYLLGEIITICQIVQFVDSDDIENVKSNDEFKTNLIDELKKRLIIKKKTEILEKKIISNISMCNGDNNFYNNYYDDDIDEDEGDNNSDYENDKNNIDSIASVSNSTKHDSNELDSNNNNNNTKLNDKNAVSNFVEMLCAGKANKYGFCEYDHKFNDKYNLKNIKNECKSSKSIEHSILSFSEDYDHKYVCLLLNNSGIQEVRILRFSKDCINTNKLLDTLKGTVTFLNELRHLFKYFRSQIFFKDKIYGEFCAYIKFHKNDPNFSGTKALNEFFNSLNDNAIKYLFFGLNEDNLNLLEEAISYCPIATFSFFKNIKLLKNMNVNSVRRTWKAVCSLQKLYKNYKKMQEQNFLDDIKYNSDEYNTTSIHQNISNNGRISLSQPPGNSKENKNELFSDYSNNNIEYNEKPFSGSNNCNNNMQSIYNNNEGNFEMEKKNLRMTNNMLETNNSIEDNNKTLLEGSDKLLTESTYKPSHENKITRDNSMDDLRINMVKLFKTYGGQCRIGKVQGRCEDATFQTDTPPAFGIFDGVGSWSLEGIDASKFSIGLSLACQREAEKMSKNINGYENVSYNTIIRSKLLLKNSLESVKKEYADAYGSSTAIVGILDEYTGKCGISSLGDSVCMILRREFLPGDINFERETYPKFPVESFLYVNSKGRNPSIIRKIIWKTTDQKWENGAPYQLSNLPDRSQWKDLEARGLHSFVKILERVDIEGDSPDMAISPPSEILCMPGDLILLMSDGVCDNLFDEEIEAYCTLAISPEEACELGDPSAYTSAQDIAYSITNIAKRRSGDKLHSKPFLPYPGKYREPNKIYKGNKVDDISCVAIWVVCENEDSVKYIAMNPNEPSILETDKYYSNNYLHHFNKLTDMCTPTKSFIKEKNRIERVNLKHINTKKGETQSTFSNSNSTNMVNPFNASFFDSSETPIKFNDEPKNKNYEDLSDMVLRDADDEEMEENYPDSNDIEFEQIQSFNKKDSKKKQTLLPSQEEEEEQQQLLENDPLYSNTSMDDMIMKTPNNNMLKEKYKDQIFNQDDDFDHTPKQRMLEQNIDEHIDIINNIYIKTPLLHVDKTNKDNSKKNKSPNKCKIKNKIIEKKMMPLMCHETPKKQIQKNDEKENKSTIDENYYYDDDENDDLINKENENIVTNFEDSETQIKTQNSKNSMLKINKKIANTKRKYNFSPGKIDSVSKMNLYSKRSKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ16</accession>
    <name>V7PJ16_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJ16"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="39008" checksum="9838A03A271D7D0D" modified="2014-02-19" version="1">MEKDKSAINNEKYKNLVDCYYLLLKKFKKKSAYVIDEFLIKENKNGDGSLILYEDINSDAFFFLILAMIDSNYDRINKINIMNMQNGNDIIKGLCFYIDNIKICDLLKKNIKNVRKANPIVERKNKLNLKKKTIDPEKKSDSIKKNPCNIKSLRIFNTNIDINAIILLSKILYDNNYSKLEHLAIDCINLENDSLKYMSLSLCNYNSLKSLSLQYCNLNNDAIKYIIDIVIYVNSSITTLNLSGNKFTEEGICSLFESFLLNNVLSNIDISYNMFNLSSPFIEMLSKIIINKTVEKKKIMIFLGKCSLLAIYDYVYMHNNVELRKYNIKHIVINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ28</accession>
    <name>V7PJ28_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJ28"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="470"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="584" mass="69092" checksum="1A199658EFA30369" modified="2014-02-19" version="1">MGSVMLENTIEEKKSIDVELDTSIKFCEFIFSKLIFFSNYENNNLAYLFGFNCLRRHLCSLISSFLNFNNSASRRKIESAFTNQLINLVKKIFENIKIESDLELKVSYTELLWRSFRRIDLTTFNIKSLGINIETLEKLKDFKILKFDEECISWLKEKNYIDKKNIIENGSFSISANKSIVNKDFILCYLGNCSIFLYYDNTEENEKCKIEIPYYHITSIHSKSKKSFTLDCKAIAEHTNIFCLWSEDAKNSIDYETVNKLSLSLKIKKTSKGIKELSTVLDNIILKLKTEENKNEKETFEWKKHKNNKKKYKKNESESEEREAKKRFDRSEVLSNSSIDDNNDIRDVLKNTRILKIETYDHEVEKGKKNEGNYKSKHDKPSNVKSYENKNVLKKIQDHERMLTDYKFDLNTPRVNEKHQNDGDRDSDIEIMIEKIISCKKEKREKFKMDVKKKFSDALNDIDTNIKSLIEKQKCRRDELQKKYEKKKKNIILNTEKEIAILSKEMNVLIENMKKISLNKNDVKKLYEEGKSIFYPSEVMDKSQVLIQRIHEKLEKMNTDIVEKEKEYSKRKKLCFKALATAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJ37</accession>
    <name>V7PJ37_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">YYC_03748</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB59020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJ37"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="12">
        <location>
            <begin position="368"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="609"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="734"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="830"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="15">
        <location>
            <begin position="984"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="697"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="255"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="782"/>
            <end position="788"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="855"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETB59020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1166" mass="137127" checksum="73983624789F86F6" modified="2014-02-19" version="1">MKKKVDSRIKTLVENNIAVGQRSMFIVIGDEGKNVVMNFYFLLNRLITNNRSLNILWCYRKKLDFFTSKKKRFREMKKKIKKGTFDTQIDNNFDSFLNNANIRYCFYKETQNILGKTYSMCILQDFSYITPNILCRCIETVIGGGIIIFLINKLEELKDIYNLTLNYHKKYNMNGKCNVYNNYIYRFFRSLNTCKNAMFIDDEMNILPLNDNHLSIKKIQVEDSKNIGINSGKTNNDENLFEKSATLGGFLSPDKKMLAKKLKILEEKCEKLEKKREERKISLYSSKFYNKGNIKNEKIEINETQQHMENNSNEIDNDTQYTFLDKNIIKLFKICLSIDQLEILINICKILRNDNEKKKNIKEILFNLLANRGRGKSATLGLILSLSIYFNYSNIITCSGNNDSVHTIFEFLDKGLNILGYNEFKDYEKIYVNGKIKEIIIFKNIKYLKQKIRYLDIIENDNIPNCELMIIDEAACIPIDILKNKIKGEITILSTTLNGYEGTGKTFTFKLLKQLKKKFVTQLTYDEFKQIKYLYFDKAFIDITLKSPIRYSYDDQVENWLNNFLCLNCNETFSIKNNLLSSPSKCQLFFVNKNVFKNYNQTSENLLKKIMTLFITSHYKNTPNDLIMILDSQQHHLFVLISASIDTNTISVNNIDQIDIYGVIHCSIDGIIDQSKIKKLVKVEDISQIVKEKKNMTVQDVNNESAKQDGDDNDNDNDNNDNNDGEDVTGNGENSNVISNHMLKNETEGNLIPYIISDYFNYYFYNYIGIRIVRISIHPSMQNLNYGSELLKKVYEYYSLYNDPKRNIINSTEKENVVFCQCSGENIYFDNKLKKIDYIGTCFGLTKNLLIFWKKNNYIPVYLKQQKNEITGEFSALMLRHINPKLKNIFITFYYDFVRTFCNLLPYSFKKLESFIIYNLLNDNYNLLSNPPRVSRIDDLKQLIQKEDANININEQIQETRNDNDSDENMNLEDDNDIINSFYNKKDKLNEENIFYFFHANDICRLKRYVLESRSSQELLYLMDTIAKLILFKKVKIDLSILEYTILYAVSFQKKTFSEISDEIQININQTNAIFRKIIHRFYNYINAIMEKQIEKEVNEEFENKLKKKKKRLVNSELPSNEYAEELEQNSNKIKKKQKKEKMALIQQFNLSGSVKRKHINLKDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJT9</accession>
    <name>V7PJT9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJT9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16388" checksum="0BCE209B0BB6C659" modified="2014-02-19" version="1">MGNKLSTEDHIFRLKLKTKELEKLSNRSELEEKRFVLDVKKAIQAGKIDMARLYAEKCIRKKNEKINYLNLSNKLDVLVSRLEGAHRSASLVKDVSVMIPLIQQINSETNAVKIGSDVMKLENIFDEIVGHILKTCTKTCTKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJU9</accession>
    <name>V7PJU9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_03120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="11">
        <location>
            <begin position="81"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="678"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="733"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB59704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1772" mass="211302" checksum="56B6F840A503D3FD" modified="2014-02-19" version="1">MRSYIYVCKFKILYQFVEKKNKDKNKICEKEFEQSYKEQIEEIVALNHIYFPIYVENPGHIKKYDIPKDLMSNDIFLKNSKELQSVVVIDMNDEIDTARCFKFCIFFNFDNDFPNYKVTFCYDNKYPYSFPNINICINRILGEQEINFIILSIKKICAKNYGRIMLFDVCIFLNEHINKVYNDGFKNLWEEMRHREYDIDKEGKNKGNYNYEKQDKSCENHIDNNENNNNSKNGSNNYDEEEIFETSDEWDRTGIVEENMNMSGNDNEMTKSIKNNNINKKYPINKDDNNNNNNNDDDNKNYLEQDENRNNELYGSYEYFINMSDVNNLSGFSFINSCTLNKNIKISKKKKYKEKVNNIATVEDELIQKYDLEIFEKKRMVKCEYNNIKNFNIIKKIPINYYKNMLIAKHIIDTNIYIIHTYTILNEIQFLAFYLNHILFCNRGFNLFCNILNDETENQKKKYQRKKCKKNEKMFRAFLYDLGIIRNVASNEEEENSNPETINNIYNVDGNDLFNKKLRNIKTQNSQLFNNNENKNDTKVAPENSYTEIRTKGYATLYNYDKNKKKNNKIIDYNCVNYFCSEYQFYANKMCVVNRQNEKTLYSILKELNIYRLKEIINHYKIVQKMNLKKIITELAKLSKIQHKYLFRYHISWLEKEYVQLNDNMAQQTNVPKIIDFMTDFVLAAIGEFSDVCEKENAFTSHKKSMPNKGGEKKSINVENVINDKKSEQNKNMLILRDNVEKNETDNTTNNNSNNGGDNKKGGSSEDIKSEINLEVNNLDKIKYVEDLISKKDKNIYKVLYVQCEYCKGQLLEKEIENNLFQNNKYLIWNIFRQILEAINYLHKKKIYIKNLNTKNMYIDNDEYGSHIKIINYSVSNIIDYIYFYYYSYIENPDYFNNIFCEFRKYSYDNFSFESLFNYMKKIKNEKTMLNNNVSENFDKKNDFYIHSYNQYFYNFLNKKNPNFEELDIFSLGLILYELWHPPFKTIEDKFYNIKNMIKKRKFSDQFIKNVNNDAVKVLKYILINTINYENNEITRSLEYPQILSLNMNGYKKDGKGISKIKKLKKNNKNILSQPTYIIENKSDSKREDALKDSLNGADNLDVANNLDVADNLDVADNLDVANNLDVANNLDVVNCDHVFDNENVMGNGENIEKITAERLLQSPLIPMVIQRDLFRYFLEKLKNNSPSECNNVINSLLYNTNNCNNKNSNMSNHIYSKKYLFETNKNSHIYTNTRTYKYDIINSYIFEYFNDVLSKKFCTYNQPLVFQRVIKREDPNFDNIIKKIELKNGKKSYIYTKKQGKYGNKIKKKLYNDSFDSISKGIMSKKKKKKKKNEYITYSFDEHRPKNNNIFKTKDIKRINKNGKKSFVETDQEHDVDVYCNSFITETKKDENYSDKIMYDILNRFNNKLELIDKNNKLLYMPIYLSAGHINTFYNFPNNKNLISYFTFFQNYFIQNNKQKIAKRENSILYTNMIIDNGHTIKSSHNIKCHVFFKDAKIESVNLGSNVYEGKSGKDGKDGEDGDMYSEINIFFCIYQLIILYNVLDILQHFEWYINKLIVRWSFSNFLFIIIKDMFSIDCNDTVYYIYTKLEEGNISLKKLKKLLYCLDINYNEHILKIMYSLIQNRDNRNINNLSKDNLLYTMKKINKMYELKNHKNKSYINYIITNIIFLNNIFHHFNQNSNYIFVWDLFMNKYKQLFNFSFVYNILYFSENDEKLLSLGGVITNEFDNMNKINTKKSYNILFEIFVDNISTIIFKVPKNLSTIIETLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJV1</accession>
    <name>V7PJV1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJV1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="860" mass="101680" checksum="6A02CDEED3351077" modified="2014-02-19" version="1">MTFKKRTNNNNNKSVIVDLRKNTIITEASNVKIKRKKKKNERLPDFSCLKKLIYEQKKDNFVHLFSFNDPKIKEKIDKFNSILENRKKHYSSETKKEDVIAKTFCETSTFGYTFIDKIQNLQNQDDINDLIQHDEEEDGDEEFSDEENETDGQANERSGIKRRNEISEKYISYEKSGKEKDGHYADNNSICSNNNNNDNDNNNNNNNSNNNRWSEKGIFNKKCIVNMKKKDKMLDQLKSTFDEFKINTLTIQQKPIHVIDENGKKKKKLFIFNMNNNNGGKNKNEKRRIQIIYDKNENRNSEIKTQNKTNRNTLNENSLYNIDQTKEPDENIIDLVNKINDQKESYLYFAVKDNNLLLNQNNDYFSIMMHYLCERSINTNIQMLYYIIMKPRNMDMLLYLILTYYKFSFTDILEQFENISINNIIESAFEEISLYDYYYYFFHTLEVSHEQYYMSLELFNGMKMMINKYNFFLNRMHRNSIFAKAKFVLGMGDIQNVKDVFLTRSSAIQDKGDVPNEPDKEAVPNEPNEEDVPNEPDAEDAEDAEDANGLSRKNGTLQYILNTKMDFINYQQNNFFSETHWNEIDNYNHLSSLDKLVYFTKDLYYKFTKKNIKNKLKEITCEQKHYDKIQIIEHCKKNIPSYKKNVQYMNFLGVYSHSFIWQIYCTQLEIFCVLKFKRILSINMHNDSRFEKLKQFFCNPTGQDPKKGAEDGPNGANGANGAKHAKASQVEYYKQNYEHVYDLKRIEKEMNKTLEILKNYVEKNKIENIFFPISIEINNELIEKTKYINGTPLNEFIYNEFLSGIDLKLRVFKLKCIIIKIIKIILKLLNLNILITLKCSRIFLKEDSLILNIGGPLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJV9</accession>
    <name>V7PJV9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2127" mass="251381" checksum="B7E6F200DCC97FFE" modified="2014-02-19" version="1">MIIMILINILRVIYINNLEITRIINAFIKYIHYISLLRYINSNYDNEIINVVYLFTVGIPLNEILDCIFTGGTNNERIVQKINFLLCCPLLFSALGILGTLIVFLIRKNKKDSKNVEKCLMINPYDFIDKKLAKKTSTDIKFSNPFNMNIDNCDMDNINVEMTIDEDEKYDIDNLKNCFILFYILYNNFLYFEIIRLCIFFGFCNYDENRKEYFLIIDDSLKCSEIGYYGKVIIIIIFCTCIKFMNYFFVLFKNNKKKWILKDILLLYQKIEKFNKVDNILLLFFLVLFYKRFLNNSNPSLIYNYKNGLYNGNIHIFQYILIIIPFFIYILIMYLYVYEFNDSVCGKCENSYDSEKLNSEKLNVKDKRKQYKNIKCISNNLYSCNNLTIDNVEIDKNEKGSGKNNYTFNGIISEDKKEPKNNSKAINNNWNKTDKLSSNNDIGMVKIKIFISKLIQKVKNPTMNKIESNDKKIDQFLFSFSFFLYGTILLSYYLFLSYVHINKFGGILTIIVIACNVAIYFFLFSKFIIYFKDDIKKKCERTLNIIIKKIKRLGLFGIGNSRKNRDVDIFKDVKKNDNSLKEKKTKMEEDLVLNKEDKNKNKNKKSINNIIKKNLGYNYNKPNFKGINSFVENNYKNIKHKAKRYKLLNISKTWIYFLYNIIDLSNEPEICLAMLICLTLQNEFLNMNLDRCLEVLENNNFCKITNLKIVLKNFIKYRNKFLKILSENSNMSIRFNNCEVDTKSDEIKSNNNVNNNNNANNNIICEDYESLIVFAWGMSILCYCNLKDINYNLSNILLYVSNVLNTCRYFKNIIDICFGDYYNYDFSHNNKDSIENNVKCNLYSYNNLDFNNDYNYINHNSNLNIMDKANNNVQIYSKDFQEPFYNDMGKSVYSENEETKFNKNNRMLTSVGKCDVIDYTTKGEYNNKGSFSGLLIKGNMKNMEHSFVRNQNKQVNKQNEVTKKKWLVDIYNMYISEVCRIYIHCLLVDIGELYFNIHYNYTCEKYICNNLLNLWGYNISNNLYMKRYFENIEKFNKNNMMDILLYNKDINLNIDGNFVLNISDYINKNVINIDFYNIFKKIGKSHRIQIKKLIKEGDYLNYNSLVEFSKIYTDYEEIEQIQNIEVDNKIKNDFFKVFSNAFPLFIEKDNYKYLDMNEINKIEEKKKFIILYKTMGEKYIEEYILKNYEGSKINYFQMDNYGAVISICGSFLKNLLKIEENQFGKMENNTDEGILKNETVKREKYIVNNNTTENDMLNKIHLNMINKNEYNYTNCEFLENKKIGIFSHNNYECKEGVTGDLKGIDLRNGNSLIGIFPSVVLPNAFTIELWLYFNSKNKNNNNNLKSFIVCDKNGNSIFVIDRKNDKIESIGIFSNEINFLSENYKRRYYICNENKKCGKKEKKNVVVNKKVYNGIYIQSEKLKKWEKINKILKINKWNLLNVTKCATGLVYYINGKYLSNISHEILNLEKSFEICIFGNSCFGNNNIGLFSSFKIFEFLNNEEIKKRYKLIKSVKNKEMIGDNINMEKNNNVIEGIDIKMNYMKGNEEEYFIYFIQSPKNKYKVVPTINNPKYGIKIYQLKFVIIKNECNKMEENIDKENRHMKSHFKIINIDNMNEYGFDFYYKKIGKKLDGVPKIYGINIFSDYLIFGCDLSQFYTIVLYPSLCIYNELVKPCGYTISGWFFFPVEKNISFLSLISGTNDVHICVFSDDMILGSIENYVRSNKNNERYTVYHSSGLSIKDIKKGWYYLSVVGTLNGQFYFINGCFKGYHKFCSFDNIKYIGNSSLFINPFPYICFIKVIGRVLSVNEILHEYSISSGYNNFTYLYYYYYLFLLFSNNEENDDGSFVSKNSLIDRSHTRADVISSDDTNSLYCYNKEKYIYFYITKNYNVYIYPLEESKNYYFTLSLVSMINKKLYIFNSINDQINNLNIYFINYIVLPEQWTIFALINIPHINESNYHCLVGGINGRSHIVIDNDNMVLGVLENAEVFKNEEAFKNKNIYEQNEKYNNDIKGGDDDNFTQIRYKEAYQKFYSCGYKFENPLNKDILLITRCINNQQTFFINNTNVGTCRSCRSAITCFGNCLSTNNEYSAPFGNYKFIKIVFGYINDDKIKEFYTNYSLYRNKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJW2</accession>
    <name>V7PJW2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_03353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJW2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF119">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="429"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB59077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="581" mass="69437" checksum="D05B4B9A57E50CCA" modified="2014-02-19" version="1">MQDDNESIDGNILEKQYEIIKCAKNHDFIKFQILIQPYILNNDIEMLNAINIMHWACYSGFTELVQKLIALNCDIEKEDLVNSDTPIYYAIKNSNYEIVLLLIKHYGSSILFHKNRRQMSPFLTAISEFNEDKILEALHILEFLYLNGISLEEQNEYGQTALFLGVKKNNISILQWLLSKNVNINHVDFYGNTILHIAVRYTDIDILRLLCDYGCLNLVYYSTFENNNTNVFQLCINNRYFLVYILLKKWLIQNKICKGLKICKTIYAFYFWFFALLNLFVYINITQSFLEIKKYHNKSVIWISLWLFQQLLWCILYFKNPGFYKENKFLTNRNKNNSNYMYATDFKNQAEYQLNNIEKEIFQINKKLLQTNNILNPIHNANQNENEILEYNDKIINLKYSKLSLYSQVSQERINSLDVNYRNAILYNQNPRNVCVTCNIIKPPRVHHCADCFHCIVHQDHHCVWVDNCIGINNQRSFYMFILSAFILLLFNYYYVFLYFKLFHNTINYAFALLVILCNFINITLFAFITYLFARNTKTILTNVTFYEHFKRPTHITDKYNTELECWEFQNLNFKKIIKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJW3</accession>
    <name>V7PJW3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJW3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030124">
        <property type="term" value="C:AP-4 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017109">
        <property type="entry name" value="AP4_complex_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037097">
        <property type="entry name" value="AP4_complex_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="51"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="807"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="888"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="972"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1033"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="815"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="888"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="902"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="976"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1066"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1088"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB59285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1147" mass="132482" checksum="DB41BD39566408D8" modified="2014-02-19" version="1">MISLGGSSLSKEFFDLAKSIGDSRSKQEEDRIICNEIVLLKSRFANPNATVKQIKEYLIRAIYIEMLGHDASFAYIHAVKLAHEKNILCKRTGYLSCNLFLNKDHELMLLLINTIQKDLKSDNHLEVWAALNCVCKLLNSEMIPAIFPIIKNLLNHKNELIRKKVCMLLHKIYLIDPTLIKEIDVYLKKLLCDVDPSVMGASLNLIFAIANNDMIYCMELVPYLVSILKQICENKLPKDYDYHRIPAPWIQIKILSIFRILGFSNKKISEQMYEVLQKTMQRADYGINVGYAIIYECVKTITTIYPSHRLLELASLSISRFISSENHNLKYVGVTGLALIVKINPIYATKHQLAVVDCLEDKDETLKMKTLDLLYEMTNPLNVQVIVDKLIFHVENSQDMHFKHDLACKIIQLIERYPPNDIWFLNKINTLFLSVGELIDEAYSYSLIKLLKDCPIDVDSDISDDFPPIDENSQSNNINKEEKYLNGEDLLKGSEDAGNDLNGESGENNKNNVGEKLKNEEDNETDLPNNTNSSKNNKNEKKKSNDDTLNLRKYAVNTYIKMLEENENIPFVLIQIICFVLGEYSYLCDLENYTAEDILDLLCECMEKNLTNPDRVKSCIITAIFKLCCYNNITDHVVTNKIIEKYKSSQITDIQQKCYEYDLILKNSELIKNVFSKNNKTQNIVIDENLSFLNPFIDKHLESGGKSYVAKDLRQCENNFETTKTPSLALNFTPYELPINNNINSDIYNASSPNLLYQKNRELSSFSNSQINEDCSSQREKGKKMFKLNVVGPKKWKKETSKMEDIEINENKNNNAKKKKKKKKKGKKNVNIYPGTNNGIINYLGEDRNKLSIEKTNKKQYNNLDNVNQSYKRGESYFKNSYYEGKTNKEVNEEKEIYNEHSEDDEDEDEEDEDEEDEDEEDSDDDSYTSENNEHEKRMDFMQDYTDTNYENLYGNSIEGIKNNKYGNLSFNKKGTNKDEQSTFRNKGMEDRTNELSEKEKMAAALFNGLVSNNTSVFDSKNIYSQNFTNKKSLSISNSNKNDLKHNKDSSNKINVKNNSFEESKNTVNPPNQYDNRMTNKHEEHDSSASIITRRNLNNSNKLGDPSKKIYSYDMIDLNEMPESRDITLENNENKEKVRIIETRHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJW6</accession>
    <name>V7PJW6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJW6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20860" checksum="290D82814CA016DE" modified="2014-02-19" version="1">MANKNIENVDDQNQAENIYYNEGQDVVAVAQEAEIVLVTTSFGGIKSSFFSSLRAQNLLNCKKFLYFVIDSNRDTGLAKKLKDEELFNKWKDDGLLIEDEKGIILPQILIDGVSIGSDVILQNLEDEGNLDYIVSRLKCPNCLAEKSNTDISCPQCQYDYVSLISEEMINGKEVIRMLQGELYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PJX4</accession>
    <name>V7PJX4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_03141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PJX4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="193"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB59739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="438" mass="49011" checksum="D4893C048E173D5C" modified="2014-02-19" version="1">MKENVISKNKDQHEFLQAFEEVLTSLKPVFKKNIIYLGVLENISEPERVIQFRVPWINDNGEHKINRGFRVQYSSVLGPYKGGLRFHPTVNLSVIKFLGFEQIFKNSLTTLPMGGGKGGSDFDPKGKSENEILRFCQSFMDNLFRYIGPNTDIPAGDIGVGSREIGYLFGKYKKLKNKFEGVLTGKNIKWGGSNIRSEATGYGVAYFAENALSDMNESLKNKTCIVSGSGNVAQYLVEKLIEKGAKVLTMSDSSGYILEPNGFTKEQLKYIMEIKNVKRERIKEYLKYSKTAKFFENEKPWNVPCDIVFPCATQNEITENDADLLIKNNCKLLVEGANMPTHIKAMHKLKENKILICPSKAANAGGVAVSGLEMSQNSMRLQWSSEETDQKLQKIMKNIYEQCCDASQKYTGETDLVAGANIAGFLKVADSFIEQGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PK64</accession>
    <name>V7PK64_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PK64"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="29872" checksum="07EA6C9448DFAF34" modified="2014-02-19" version="1">MEKNYKIVKYGNNFNVSKELRSYMLKIMKEYKDYFEKEFIKNCNLENNINLMENLEIKEDNDYNEDVFIKNQKSFHIYDFFNLSLLFPIKILNQNGKSIIQLISEDNTPNDLNMIQTILKNIEQTEMDKLRFFHIENIIYELIDELIRQIAVDCPKRGFSLIVINNEIKKNIDYYKRLIEIIEHNNNMNTEKFNEMQRKYSIMIEQLSVEENNLKEKLADIQNELELLRNTNKKKAQENRNKMEIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PK66</accession>
    <name>V7PK66_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PK66"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="598" mass="71004" checksum="B87344050BE4C578" modified="2014-02-19" version="1">MSLSSENIFSKIKNNEYKKVGVKICSIPIQNEDTNKNEFSINKNDFDTNKYFKLKKIMLIFEKLTNEHLYILLYFSLSILPTIFHTYLTIKFSKKKNNKINSYLINTLRQIKFEITNTLKTKTKKNDFSKFNTNFWNYINNINLDAINKKCKNCGKCENCENCEKCENCEKCKNCGKCENYISTINNKMKMLHTLEFHTDLMTRQDANVTKGKRTENVRETKRDVEKNAENGGEKNAEKNAENGGENDEGEDVETLEQLLKDKMQVKNIYKYIKKKKYTYNCKGFENIIKSVSIIIEYNIYSFFINKIGMSSYVGKNNLIINNLNIYDENNNYIIVRELKKDNTLIHNEYIKKKIKKNKIYTYKILNNKIEALLNTKEFMENIKKEKGNKYEKDKKKKLDFFYIGTENNNDCNIINNQNNIYDDIFKCFKKKTNTDILESDIDSYKDSNSSENLIFYEKTKKYFYKNKLNIDYFTYFITTSFYIFIHFHNIYFSSTFFNIFLTFSIKLAYKYTHNTNYLPSSNLTNQDHHSPGNHPPDNHPPEISPGKPRETKLNNKRFYKNIKKDEMGSETVPLVKIPMNNFLEKYQNIKKKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PK81</accession>
    <name>V7PK81_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CMGC/GSK protein kinase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_03437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PK81"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="62"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB59187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="345" mass="39864" checksum="63DB026C3CEC2596" modified="2014-02-19" version="1">MKDWHTDDDNNACQENEQTNNGIDNKRDDDNNYTSIEVNNVCIEEDQQIGENEISKSSNKTYKLGNIIGNGSFGVVYEATCIETSEKVAIKKVLQDPQYKNRELMIMKNLNHLNIIYLKDYYYTEAIKKNEKNVFLNVVMEYIPQTVHKYMKYYLRNNQFLPIFLVKLYSYQLCRALGYLHSKLICHRDLKPQNLLIDPKTHTLKLCDFGSAKSLISGQRSVSYICSRFYRAPELMLGSTNYTTHIDLWSLGCIIAEMVLGYPIFSGQSSVDQLVRIIQILGTPTEDQMKVMNPNYADVKFPNVKPKDLKKVFPKGTPIDAINFVSQFLKYEPLKRLNALEVKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PK85</accession>
    <name>V7PK85_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PK85"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43336:SF3">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43336">
        <property type="entry name" value="OXYGEN SENSOR HISTIDINE KINASE RESPONSE REGULATOR DEVS/DOSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="318"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="676" mass="80169" checksum="B6F2FF092AF73C5B" modified="2014-02-19" version="1">MESMKNKTCLKDNLKFTNKMHLTLIKRFFVSLIFVMLSYILIELVTFSKGNKSSMSYFIYNIDRTNFDDHYETEFLKALYFYSNIQRTKNDEEYLISFKSKVKLQNFVNKKEINIGKEKHILWDFTKSPYTEMMKLLDMKIPNAQNEEEITMDSTIKNSSQLRQYEMRVYKSKDFIFYINIKKKIIQKIKNIVILKLFIILFSFFILFYFSIELNILLFPIESILKKLKLMKSNPTLALEMQEELLNHELDNILRTKQLKKECIKGNYEILKMEENLMKLGTLMLLGFGEAGAKIISKNINDQERINLLINGEIVYSVFSFCDIRNFTEITEALKEKIMIFINLVAEIIHECCDFYDGSINKNIGDAFLLVWKYKKNYCLNKNFSNQEYTKTGVTSYEYYSEKKKINRICDLAFLSTIKTLIKLKQSEKIRTFLKSEKIDELVNNNIIELSFGLHFGWAIEGAIGSRYKIDLSYLSENVNIASRLQDISKIYKSNIIISGDFYDNMSENFKKSLRKIDRVTLKGCANPLNLYTVDLCLNKIQNEKTINKFDIIGSTSNSDRKMTKIFDDIKKKTERRRRKKQLSNLDYDLFLEYTKSRDIKLVKVEYPEEYLNLFEQSLELYLNGKWNESKKLLDNLKNKFYFEDNIVYQLLDFLSSNNFTTPYDWPGYRMFLHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKS8</accession>
    <name>V7PKS8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKS8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="620" mass="74601" checksum="AD832347848F043A" modified="2014-02-19" version="1">MNILCYVIFKKFSYEYKNDNKNKDLLVFLKKIFPFEFQNFQDVYNKRWSNDFTSPENIIKQQDNVEIVKEVYNVDDNKLESDGINRKTNNTLNISDKGKDENTLNHENKYANTSNIKNIANSSSICLNLYNNNNVLNHKEKNGMNIRCMSNNMENVLIKTEKIDDIDNNVNHQSDDDNCYDSTEHNMSIGENNKEYNLEELKKSVKKEFIYDDYIFKNKDIQKIIKNLFDEKRFDYRLRFRSILSQTLNNEEYKKYCDLREKLFKYKKKKFMKWISQFTKINLLDLYAVNFFIFLFLDRLYLIIETYIRLNYCGKEYPHESSDNFLEDINEFQTFNNILNIFGDANPTEQENTLRNGFNNNAKNEQHIQKFKETYNNIIKEKFSNFFYSIELIYNVDVYNFKIKNKIKFEQLINTDISTYINETNVYDIINYDKNVNSDPWKALANFALLHNRNLKLEKFDCFSLFLIVRFKFYLEEFKENANIDYIYKTVKEEFDKVQNYLESQNGLNDVSKDIENKLSINETNEENQNDENEHDENSPNDFEINHLVNLYLDLQKELKKVNDYMKFYGNLISFVNFIQEYATKSVKNIVKSETNEEKKKYFDLSFFLSTYVKEQFKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKS9</accession>
    <name>V7PKS9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKS9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="1">
        <location>
            <begin position="134"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="25245" checksum="BCC9FA4C34E87A69" modified="2014-02-19" version="1">MDNNTILETFTNTDLEKLNDLKSSKTVTDQKIRYDWSQTNNLVFFTIYQKNVQKNDFLYYIQSDHISLIIKISETEIYFIEKPIFSKIIPSKTIINITPMKIELSLEKNIKELKWDMLEKKTNNDITEKDENILNPFAGKSVQEWAKFAQSIGEDEDNQSIDHFFRKIYEDGDDDLKRAMIKSFQTSNGTVLSTNWKDVQNKNYEKEKNNKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKT1</accession>
    <name>V7PKT1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine protein kinase, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKT1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055164">
        <property type="entry name" value="EDR1/CTR1/ARMC3-like_pept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14381">
        <property type="entry name" value="EDR1_CTR1_ARMC3_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="646"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1019"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1271" mass="147317" checksum="D7F96A7C9A44B5D9" modified="2014-02-19" version="1">MHNNSYIEKDNFICLNNNDTNHIIKNGTSHNISNTSTGVSTPISQDNVICNNSNSSNDNSNNISLNGNKKSSSNGNSNNINLNGNKKSSSNGNSNNINLNGNKKSSSNGNSNNINLNGNKKSSSNGNSNNINLNGNKKSSSNGNSNNINLNGNKKSSSNGNSNNINLNGNKKSSSNGNSNNINLNGNKKSSSSNDNSNNISLNGNKKGSSSNNIVDIRNNNSGDNEKLGQLKETNLDNSEPEINPTEKSENAQKNYIEALRKLKSNPEINLKRGDEISKNPCLFIYDNLILKKKNEKVQKLIKKLSINAFNLYFPKSSNIYNQMPMVLSLLNGDVDDVLISLKYLIDYFDKINFLIVNILNKLKKKNKIKNNQVITHLIDFILNKLCEKNINYKYSKTNILDFYDNLMCPGTSFFESGIKSEAINLKDLRLIYFYKHDIKIKKEKSFIKKKSIDINDNEEDILLNNYFIDKDRNIHDFVIKNNENKLNYNKYLKKKKHILTGEIPTPNIYIGINEYFNEKSIFDFDYFDNFDNFDNFDNFDNFDNFSKKNKHPNDINKYIRKYIKNKTKCTQNENNICNCITNIIVSIDNDAKLRNHVSAAKNETKNIKNILIKIRKIENLVDRIIKYDHENQIIYSPDEEEESEKSESEKSEKSEKSEKSEKSEKSEKPNDEHGDIKSKGDIFDFEKSDNFNFSNNKISVHEKFEEKNDEDVMVETDLNGDNTLDKYSKIMEPNQEIHKEKRIRDENDNNEVVKICREICDENLKIENNDTDKEVEDFDKINLKEKENNLINCCIKNESTKQCLNKYNDTLKRTFSEIYSSEEKKQMKKQKTIDSCDNDNDNDNDNGSDESIKTYYWENLDFNCVFLGSIKKGTCRHKSLLFKVLCDAVGIPCRFIRYVKNGQVQYYNLVLIPSIPAQNVVEIIIPIFWDKKIKTKSNISGYNKISISSFLNNIKMKFSNIDNFFLRTWENSTEFINIDDYFTLNKKLGIGGFGEVWSVSLKNEIEDNSSFFFFSIKKTSHLALKIMDINEFNLNESIIMREKAHTNVINFYCVFKGYQLLTNRQHEKERKDSFCFLLELADTSLEKVFSDQKVAYNLNFVRLTLMEIANVMSYIHKQTPNHEFYIYRDLKPDNILIKNKKILLTDFNLSRKIDEDFEYLMSQCCGTKGHLAPEQKSLVYDQKIDIWAFSIIIAKFLKHKNFNYFSHDNYKVDLKHFEIQDKFLINLLLVCVDESPFMRPSFSDIFRLLFDEIVRNELEEYYRERALHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKT2</accession>
    <name>V7PKT2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOT family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_03021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="3">
        <location>
            <begin position="2004"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="2">
        <location>
            <begin position="3586"/>
            <end position="3822"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="2">
        <location>
            <begin position="3936"/>
            <end position="4053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3243"/>
            <end position="3270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3444"/>
            <end position="3468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3865"/>
            <end position="3889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3254"/>
            <end position="3270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3444"/>
            <end position="3459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3865"/>
            <end position="3874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3875"/>
            <end position="3889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB59575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4061" mass="468796" checksum="2D5C91B0EF459801" modified="2014-02-19" version="1">MRMDYHEKRNYFMSIKQHFSFIKKKNNTNVNASSENINKSSLSDYDNSTKTGNEYYEEDINKTENSDSIININEKNIGDNKHTSDDLRASTNSNKSVNSNMDDWIADNNIASQNSNNNNIHNNDNNNSVNKIHKNIGGHVKNNDDKNQCYSDNSNILNSNTHGNNANSNNDDHLNKNIMNNSDSPNVNNEFDISENQTSIQKNMKNKNNDIKNGSINMEQNDKNHNYDNQYFIKNEDTEFRNTDKLPKQNMIKTNSYIKNNQGKQPPADSNNENQRDSNNNTNNNNFDNFNCNNNIANYNQINDSNNNEKGLKTHLESAKCDNYSYKNNGKLVDIPNNKPINTNKITIDNLNDINKSNNVKSNSDANLNTDMNAKSKANNSIHENKDPLFFEGEKLQLNNSKEETSLKQHDNNNNNNNNKSNNINNNYNNKGSNKGGGKRSNTGGNPINNQNDNNKSSNNSNGNNGGDGHNNNNNNKDDNKDNNNDDDENKGGGKNNKGNEKGKNRNNKNNKNNKNNNKNSGKNGHKNSHLDRNSDEKAKENVMIRGDKKKKNNSANNSGNNNNNAKDLMNLKIGSNMRNNTNNLNRENINKITNNNNALYNNNNVHMEMYENNNEVCINNAIGKTNVGMNFNGMSIKKMNELCNNMNNKMHINHMDTFDNNDNIVHMDEEINHFNGNNFDVKVFNNMNVMHNINNINGLKDLNDMNNMINNMECDIHNNFMAYYGLSSEEFSNINNKKHDTDIIIDNSNKNSKNMNPNINSHNASTYNNIYNGNIYNNNNDNNNLHESMIYPMNNIKNNTDIKEYYQYYNNNNNPIQNANSSYYPDHEEKIYLNNNGNINKFIEYKKNNMPYINRTIDDKYEEENIFQNSYAKMDMHELNKSENNNNFNNTLKSYWLYNKDNIIKNDVINNKINMNIIQEKNENKNQINPNLEDSLNYNEANTLNLLNIAFNEIFADKKHLIEKTITKRFMKKLAAVLKDINPDNIKGKGKQLKKLILNKKKTNKQEKHETEKNKKETNKTSNVKISNDTKNEDTKINGEEIIKECDEKNVKDTIDDKKEKTNTNNSSDSKGNKEENNNNEMNKSNELEQKEKKSKSKKNEKNSTNANELTAISEDTSKEVNEMENKKEFDKKTGNKNNTDNGQSVLKDDDPKCDPNSLCTKDDNVGENNKKGIEENIENKKNGFDKDETISNNNKNNNDDEKGETQNGNSLENIKREDEFFEENKIDGVYNKEIKNYQEQKILDNNASENINENVENDNTENNERNENISCHSGSSTYEYLNENVEDSDDEGNDENNNSKYITGINDRYEEIKIEDDVMIRRDIFFFNLLKIVIKKKTSEDMLIYLHLLNAINIDKIFDYIIQLSCDIFNTLLNFIEITKDSSTYRLLLKNLGAWIGIITIGRNKPLISKYMNIKQLILYSYDNGYLIVTFPAVCKILESIKNSKIFKPPNPWTIGILNLLGELHEAQSLKTILIFEIEILFNYLKINVFDYYNKCNIIKCRNMPINSNDLFVRNNYNDNNSNTNVNMGYVNDNGGRHFANTSEIRHIYNKTYNSGANFYPNDNFINNDNRTNRPIGLGDASSANYLINKDLRYNNMINTHNGHIMGSEATSTAAISTTSNSNTNDLYNRKHLSANLLNKGDFVMINDGNNITDSEVSANNKNNFEDSNLMQSLSKNFKNMDNNLTYNKQIYKSSMTSELVLKNNASQRNITGANAGKVNNIGKDSHTMSMYNYMNNEQPTYNPMFGNNIDMYANENDLYNNMYNKNMEYMHSMSGEHIGNKNMNNINNNGNNDDILMKDLKYNAKKKEKMIEFEFKDNSSKNPNYTLNKNKLLLNNNKLEHQRFKSSDIKDGNVGIKPEIYDNNNKRDSYSSQLINNMKIKNMLPNTVDKMKMADYMNNNIMHASNSTNKNNLNDGLITGNNNNNNMMDSSYSGYPGVDMNMENQANISYKDNTTNNSINNNGSNNNTNKFNEIIFDEISNILKKNIVLSPSISILKLNFKYKALIYLAFDSAIKEIVSSIVDRFVLIGCITTRELVKKDFLNEQKETIIQKASLLMATSITSSLALVSCKKPLKNVLIQNLRNAFEQNIPERNNTIAIDDIIKILINDNINLIYLIIEQIAIEKSSIEIEEIMKPVYASRKYARIHKLNIKDNTSNKYYNTLPVFLKAHNITLKHIQVYKNFMNLKNAKSLQQKLFSVTNNVHEQERISNEGNTTNRNGKATKGMLNDDGNINNFYNNKKYGIMQHTLDGRNSKHGDYKLSENEYNKETLNNHNRQEDSKCDNEMKKNRYSEESYYNEKGIIEEDINSNIAGTKDVGNNNMHQQKGASNIGYKNNEGVKFIPCKNNNSKENVNFHLGNLNSNINNLNILNSNAMNNVNLNNLNSSADGDTAKIPTSDITNIAINNNANYMNNLNLYYSSNCHYIYKNSTNKYNCNNSDNNFNTNNRYVNMQIINNDGNSGLYTYGDQYPPNYSGNYPRNYIENGTNNFSENTENLYSQNSNQKYENGYTHHLPKISTNTIFQAAQNLEDLKNGNMHPSNNDSEISFPQFSNIPLNPNFESTSSPIPPYMNNIKMDCSSLNGNINDTKTVDLNNEHNMTTFNSDVLNNYDTTKNVIMNVNKDSEKNEKENENKTNVTNYGITHINRGNDNNDLNNNYYIDGEQINNSKILTSISSDCTDKVNMCLKKINNIDLLFKKKYLFFISEIFLKENKEKINTKNIISLFEFCMINIKDYIKYLIIFPPIISTSNIYSGYCNIKTPFFKFEKNIYTDITPLLFITSLSTDHEIFKLCKIIIYICENSENQSDTYKIIGTKLYRSIQEMLKNKYIINNNIANVKEEKKTFHEQGHDIFPTNDSDTKNNQNKTNQMNITYNETDILIEIQLCILELMCIKSRELKQLITSYILSSPYQNINSISYFIRYNIINLKRLDKNMRNHLNNLNNTNAIKFCTELIYLMVIEKKYINSDNLKNSIKQIAKIYNLLSNNSENINKDKKNVLITIRKKAKQIIKGIKKIRKNKTLETIKVLKTVTEYLGESKAKESNKINSRKMEKNTIKKDEDGDKEVKKRNNICTQLQNDVNTQCDYTNIDEYVVFLLEKLNYENNKNFSTEDILEKEIIKINADEKNGIKNHTSNTFNNEQYSDNHLKCDLEQNEKHNFKSKSEQNTNNNECNNNVIVSEYCENTQCNIYKEKEEGYNSSETGSDVTCTSLYSNKSEKSRNSSENSSLSVCSIALDSKNNSKKNGYTNETDVSKSSYSSDSNSSSASNISTISVEHKSTNLETNKEIDIKIPVTEKNNLLNNFINIKKMNINENYINKKAYYITDIFNDKPIKCKYLPSPPNINKEKGMIIACLFAEWYFIYKNYLNISKINAPSNTPDILKQQYKSKCIKYIQKLIKFEFLNMDKMTDCFFTHTINISVNIALYNLQKDDVIKDELTNQKLHQTEKENDKKGTKQVEESQNENYEANNVSQIDNDNKIETLKNNIEMKELKNNSELLNYNYIDSWSKMIVIILQLVEDIKGISPIIVFQKVLNSLCMIIHKRCEIEKRKFNQRPYFRLLHCLLNDINEAFTVSIIPNNVATVQSNDKLIYLNCFSNCFDILSPIRVPSFSFSWLELISSKHFMPILLSNICGWGIYKNLLVALFTFLKYCLKKLQISKAIESLYIGTVRILLVLLHDFPEFLCSYYVTFCSLFPINCIQLRNIVLSAFPRNIKLPDPFMSNIKMDLLQEIKLVPKILTNIIFPLFKNNFKQLIDDYFNKKKYSLLLQIKNKLYLPKNKIYQHFVKYDMDIMNSLTLYVGAFICKAKTNNLFSFNSNSDPILLIKPKNDTSNNTKEENKTLSRDRDIIQKIVLNYQGEILKRKDIKEGDEKQPNQENQRNGEQNNNLPNKYVDLVQENNIENEISSFSNCDKTNTKVLKQNSVNNKEDNDGTIEITIIKKNLAYTLFLFLLKELDMEGRYLLLLNIVNHIRYPNSHTHYFSCLILFLFSYSNDIVIKEQIIRVLLERILAHRPHPWGLLITFIELIKNKKFKIWEYPFVHATSEIKKIFKSVFQTCLGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKT3</accession>
    <name>V7PKT3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exportin-2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKT3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-2 C-terminal" evidence="1">
        <location>
            <begin position="881"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1258" mass="148990" checksum="A12FBE4CD177A454" modified="2014-02-19" version="1">MEENVEKDFLTIFTQSVSNNFEEIRLSEQKISAIYTDSNKENYIKILFKLIMYPYVEENEKKNIYDNYLNINVKTSILISIKNFIKKNIHSNLENLKISNDLCIIIKHLCMHLLLDTNNNDIKQLDKYLFEILVHLFKYNISDEYDYILFYIIILYLNDGSFNHILNIINNDDKKNNMNAMKNIECIILYAQNKFILQNIDQNNYNVEFDKIMENINNIKNVINNRNNTMNDDIVNCINDTKKIYKSNDKYNLFILDDYMLYNISKENTSIQPNIENNLEQFIINGFNFMGKGIIIKDYNNNANIIDLAKYNNYNSIFNNMNVNKFKNKYIALKILRKIIKKYKDNGYVAKFDIKIILTHIEYPLTLYFIYLYNKFREYTNYINIKLNDQKNGCITNIDNEINICFYTLNDIVMNLYILLKNFYNINTIDLPEYYEDNFDIFFNIFYNFITYDIDVLRNYFLHLSITRNYKFGQNDSTKYITNIQNVGGNSNLLNLNGSDLANKLTSNNYMEKLINNFQQNMIKCKIITIDIIKIISERYQDESKTYILKMIYSLIDILYKEKDKTLLCHNYNCLSSTIKLIYHMHLEKSDLNPYIQVKFIEKIIERVLQHIKLKYNDIEEILDADLDYFRNDLNNSNAFSIKPSAIYFLKTLCSNYFDICFPTLKFKILSKNSFLASDSKQANQSQLTESPVSNDDIDSSNPFFEPCNMEYKVQLITCLNQINLSTNFYQQNIKNDLKNFVISIYMKYPNFDSLFYNVNDNIFQNNQINKTAQVGSTATANTNTAASNSGSIANKSVWLKNEEIFNPHNTIYLLSILKFILNNRNICTTEDNIVDIFSFLYHLLYNERNMIHNYSCLCINRLLNCQINKELLDGIYQNLILNILNRLLFLLKYNVYNKILNEYILITILRIFMIFSEKISNQYNILVLDLIDTTIKIIINDSHNPIFNHYLFELLTLIISLIYKNQNQTCIDMIENITISSFSNILELYIHDFIPYIFQILSIIINNTYQIKNVHLNILSNLYQMDLWKSSVGNPNGIICVLTSYFKKHNLFQDIIKNNMQQLFNIYHYCISNQKLSIDSFQIILIIFTYLPIEYYQSFLKPLFVLLFTFLQQYKNDIIKIKVIHSLSVFILKTDVTHFLSIIDQVQPGLIFNVLKSLYMPIMDKLININEKIIIFIALAKIINNEQIKRDPIIVDILNLLDKNITKNELVMKKNKIQQNFGIEKDEVDKDFEVTYVKLQMINNENINETVRHFKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKT6</accession>
    <name>V7PKT6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKT6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="568"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB59412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="983" mass="117808" checksum="2599CCFFDD51E75F" modified="2014-02-19" version="1">MDQHQNYSNEKNINNEKIRKDPNFSEKLLKNLRDNIFENNNCINMNSSENSSFLQTNLEKNTNFYINESEKFRDNQINKNCTNSIKREHNVDGENVPISSCNIDINDNSSDNNFKVLEKLHNGDIEHTNFVNDQLDNSKQNVCGNIKRCENGNAENVEKIEKSGSTENVEKNGSMENVEKNGSMENKCTFKMEEYISNKSVEGNTFKENKDQICEDSKRCEENENPNLETKRKNEHSFSKEIKALNPPKNVYEYNHNVIYHELYIELLEVNKNLQNEIKNLEKIIEMQKELIKSKEGDIFENNNMIEKRKMSSKSFVNNNYFLNFFNKKNKTSKKKDDEQGKADNEEDNEIFEKDEGLAESNYNYNQQRKGSMTRFQNMPFSFFSDKSSKQKKQKSTESINTINLSIQEKDNEKQKNKRNIGTPKWTKQFDYKWIKSINNSNSFQECEFIYNDDMKKNDEIDNDENSDINNKYMKLALRENEYVEFYDNDDSCTFDNSNNKMNKKKSYTFFKDKSNSKEIEKYRDCDYKDINTIKEITLIKYWYNKIIPLINDEKKKYTLIELIMMNYMPQVIREYFWKENINNKLNITDYFVKVLIKNANFIQIYIYINNKQYYNIFSRYFKNLINLEKSSINIVPSLLTENCFVDENELINTVKESELYKKMITEKIFIEDDEEISIDIKENGKVTCSEKSIKMNTELNSISSNLNKDEKCDKENNKKDKIEMKNFEHLNINILQRYSIHKFFYQILIDLDRTMYIIKKNQEYYHRTNIDKDNFLFDLNIHDIKKNLNKLLQMYVIFKPELGYIQGMSYIALVFVLHCKLEKAFIHFANFMEYKNMRNLYSFNKQEIKIFLFTIKEILTKKNIDVYKEIVKHYNIDNIFIQWAYTMFLTCLPFHIFIRTFDIYTFNEKIIFETIICIFTYFNKFHSTENVDTMIKNLSSFSLNMNIQEDKFFSTLKKSRIKKRKIIYYREKYLSTLSSKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKU2</accession>
    <name>V7PKU2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenylate kinase-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKU2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29803" checksum="BCCB0FEF35F4F803" modified="2014-02-19" version="1">METLLDSETLKKYEEETNEYINKKNVEKLFDIIAKNVLINKPDNVYLYIYNNIYSFLLNKIFIIGPPSLKITSTISSSIANSFDYYHLDVSHLVSSYISSKENDTQDKQSNQILINDDIICSAVKTHINNLDAKKKRGYVIQDFPKTNLQANSCLQYLPSHVFVLIADEEYIYKKYEEENNVKIILDTNNQIYDEQSNLFEIKEISTHPLEEKVKEYLRCIPGVLEVIGNNKNVINLRDFDEINVVDQVMVTLTPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKV4</accession>
    <name>V7PKV4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKV4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="1">
        <location>
            <begin position="377"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="428" mass="50496" checksum="FC6C3239CEBD17BB" modified="2014-02-19" version="1">MINKAIKKLVSKNFLCFTSRQKQNKIINHNKNIISINVSGIRNVSNIRNVSNVGSGLFDGIPNEEIDKDKLIYLVKNMQMVNLKEKGILNNISNLLKRHMNQFTIDEIYLIIHSFSKLDFRKYSLYNNFVKIIMTKKPVINTRTLTQMLIDLHKTSSLDLNALTFFTQYYINNLVKNFSLFDLSMILYIFNKYNYNDFITVNKICQTISDHFIPIIDEDKGVLTTILLSLSVLNLNYEIYSNFLKLYVYTNYEKFEIKYLCNISYSIALWLARGSVKDKFLSELLKDIVFLLINNMQKLKNDELKQLHIVLYFLRAIEENYEDTIKKIEKKNIKNTITVSKMQHQVEKIFTEIGLNVNKEFPVGPYVLDFALKKKKIYVEVNGFTHYYTFDGKINNKTNLKYFILNKLKWKIVTIEYMDWKNKSKDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKV8</accession>
    <name>V7PKV8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKV8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="378" mass="44348" checksum="A4867F6AB0B066DB" modified="2014-02-19" version="1">MINKAIKKLVSKNFLCFTSRQKQNKIINHNKNIISINVSGIRNVSNIRNVSNVGSGLFDGIPNEEIDKDKLIYLVKNMQMVNLKEKGILNNISNLLKRHMNQFTIDEIYLIIHSFSKLDFRKYSLYNNFVKIIMTKKPVINTRTLTQMLIDLHKTSSLDLNALTFFTQYYINNLVKNFSLFDLSMILYIFNKYNYNDFITVNKICQTISDHFIPIIDEDKGVLTTILLSLSVLNLNYEIYSNFLKLYVYTNYEKFEIKYLCNISYSIALWLARGSVKDKFLSELLKDIVFLLINNMQKLKNDELKQLHIVLYFLRAIEENYEDTIKKIEKKNIKNTITVSKMQHQVEKIFTEIGLNVNKEFPVGPYVLDFALKKKKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PL51</accession>
    <name>V7PL51_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PL51"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="55"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB59532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="275" mass="32661" checksum="B34577D1BAF359DF" modified="2014-02-19" version="1">MEDIIIYMIIIAPLTRWIIGPNRPWNKGKREYGVFIALFILFCVAAYELKKPEQNAYEILNVNTHASTGEIRQSFRQLSRKYHPDKNKEPDAFDKFNKIREAYEILSNDKKKYNYDRFGDFQGSDITSFFYIEIIIIAIFQFAISFIFGFLYTYGRDNEKYRVLICLYISLNFCLELILRFSSESTEFLAFWPLFNHYTPFERIKAIKALVPLFMNIILFIDIYLIEDDIGVYALTFCEYIFKKNLKIVKNYNDAVLFCAKLVDGKFFFFSPPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PL62</accession>
    <name>V7PL62_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PL62"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="406" mass="47891" checksum="5A80A0191EFC91D3" modified="2014-02-19" version="1">MYKEWNFLNIICVILTFYSIFYTKTVFSKDYGNNIYDVLYVASISYILQKRFNTKKMGIHDFQHCINSETKNIIDLIQKGVILNIIPLIFSYVLSFIIDILLTIINSISFNIILSILTHPFDVILNLPSIYNLSNIYVLSSFSYCLSILSAIWISAILEYHFIIFNFLFNKYDYKVLTSLNKFPMHNQCSYHDEFFVVTCIYNYLKDVSYRIKGHNIEITNMDKKTKLKLLLFKKLILINASLKYKDEINILSHICNPINTILFEDNKFWNTYIDSCILCIEDLICQLKRYINILNHNQTVYSIEEKLELKNIMDKHRINKLKDTIVLTCIYLKGVSLWSIAIIIICKNVIVSVIRKLSSIIVSLSYVLFDFLNFIKINELYDPLHHLLYGKPKFYISKQTNVFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PLZ9</accession>
    <name>V7PLZ9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_02883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PLZ9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SURP motif" evidence="3">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="4">
        <location>
            <begin position="192"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB59368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="54883" checksum="8A1C389E09C35BB5" modified="2014-02-19" version="1">MYPRKEEDKKKGRISGFVCFENKEDAENAKDALDGVEMFGKPVIIGWSKAIPKILSLNKNEYKNSHFDKNKSSFNTSNKRIQIILPEDKKVKRIIDLLAKYVTEEGYAFEEIIKKNEKDNPMFNFIFNTSDLHYYYKWRVFSFAQGDSYRNWRVDSFQMYENSYVYIPPVPKNKKDNVPRINKKMKNKKCDMDEKKKSKLISIINNLSKKRVSICRAMIFCTRHSDFSFDIVKIISSYLTDLKYDLLKKINLVYLLSDILYNCSNQFFSSWPYRKHMEEALPRIFYYFRKHIKKCDSKIKAKLFSDSIMSIFNMWDTWAIYTIVFMNGLKCLLSSKKLNYIKNKMHDSENEHDILNGTKIEFFDDLKIYPLNLRRNAYIYFQKDENQINRLCEQRGLYYDENFNKKKKIKYLLIYDDFYGFNTNNVGSGKNYLNEVALSDGNKNSSSKISETSDTALHDNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMX6</accession>
    <name>V7PMX6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMX6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="432" mass="51199" checksum="92061BEA47B3F66B" modified="2014-02-19" version="1">MYKEWNFLNIICVILTFYSIFYTKTVFSKDYGNNIYDVLYVASISYILQKRFNTKKMGIHDFQHCINSETKNIIDLIQKGVILNIIPLIFSYVLSFIIDILLTIINSISFNIILSILTHPFDVILNLPSIYNLSNIYVLSSFSYCLSILSAIWISAILEYHFIIFNFLFNKYDYKVLTSLNKFPMHNQCSYHDEFFVVTCIYNYLKDVSYRIKGHNIEITNMDKKTKLKLLLFKKLILINASLKYKDEINILSHICNPINTILFEDNKFWNTYIDSCILCIEDLICQLKRYINILNHNQTVYSIEEKLELKNIMDKHRINKLKDTIVLTCIYLKGVSLWSIAIIIICKNVIVSVIRKLSSIIVSLSYVLFDFLNFIKINELYDPLHHLLYEMNSIVDIFKFYKEDILDNKYQYSYNLYKGLSYLFRNKSLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMX8</accession>
    <name>V7PMX8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_02470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMX8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="46"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="201"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB60102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="278" mass="32793" checksum="BF9120195BD7555C" modified="2014-02-19" version="1">MFMEMRKMFMECEKCSWKCMILYLYMLIVYLCMLIVYFFLGQKYLYSIIISNVNSNKLELYKKEFSKFGKIFNIYHDNEKKITYVKYDNKNSCDNAISAMNNSTLDGDTITIVLGKKILDKKNNKNLIQNPNIVNNNKIIPPYKAPMYNTNPFPYYMNNNNFNVPYNNNIPYPNTFQNNFYDKNIQPFNNHKNIYDTTKNNTIIVTNVPTYLNAEDIFSAFQETGKIVDVQILMNEKRKLTGIVSIEYEKNESASDAVRMYDGGFLNDNRIRVFLDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMY1</accession>
    <name>V7PMY1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMY1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="292" mass="35169" checksum="73100246926174DD" modified="2014-02-19" version="1">MGNILGSIIGNKETNPNKTNISIFEKRYGYNLNDLHSYIYQINLPLKPPYINYVFQEKKEKNESMEIFNDKNNDNKTVNDLNNTVDIYNKYDKDNINNSNNIYKNKLIINNVEDNKKHDDKYVHLGYNKNYIFDKNKNNIYTEDNISKYISEQKMDEKNNFDIKKTYLNLCLNYYNNIDTCVTKKYQKNVQNKKYKFTRLHTCKPHYILFSRCVKFRDKKIMKEIKKMELDYYNALSPQNKSSYLSEFSTNLSYHEYRINQAYEGVEKIRLNKELNELRERYNNILKSNGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMY6</accession>
    <name>V7PMY6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMY6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="931" mass="109702" checksum="D6EC7D69016A9F5C" modified="2014-02-19" version="1">MSMSILPFIHRIFSELIYGYCSSLSMSYENYFKDITNYEKKSFTSSFDLSSATENSSFVIEKKLALFYTLKSIFLLIFKGIKINKCYLNILSDCSVLCFLDSNGILVNTNHSVKEICIYNQLNNKKNVNDNNNNMKKIHNYYNNILTIIDIFMDNKSMYAYQRIQNIKILHSLFLISYFTQLLKYIKNLDDFQNNILNYMNHQDYNHLYTCMCDIGNISYPYNKFSFRMLFFCIENKSDYELYKKKNLELKRNKKGKIDGEIPYYVDKNEKGNELGINIYDNLITRDNFVFIFILYEKKKNKYHMFFKGQLDALVSKCMFYYDGKMIKKLKRRKKKVLKILNMQWISSGLESICFAYRPLSTDEINYLKTNFTKNIYILTINKRKVYNIKNFYNEPNFPCKENERFLSHLISTSIFIGNSAVKILTSNDIQARINDFYDAGIRFVYFSNKDQINTRNISNTLGMETNWNTSISLSLNDKSSFRNRDGKVVIPSGINNIKTHIQEIDDIPLRVSSYSGCNQFNTAEMIKILLENNEIITCVGNSLNCCNFELYKLCNYSISVLLPYNNICTDCYGKKERSNPFGKPAVNKNPLIAYSSFVNSFPCNLTIEKNILDLSENIMELVYKLLKSSRIYKKNLSISMFYFYFYYCYLSFLLFVINVFFLPPLISLVDYLLLILFIIPILSISLLNNNNNSTIMNDIPDKVISIDFLVKKLFFFLIRWVSFLTFSIIVSVYYIHILNDTFVDKYVIKGTLNSDKLSSLGQNFVKDVIYYCSKNINIKSLYKCHIFMHRFSENQNMNRDNIGVSMIKQYQIFFFFSFSLFFFVSSLSYSDKYEALFKLSCIQNSKSYFSCLIVYLILSFLYVAFRIYMLPIYYIKQYPDTTLILLLAIFSIILLLINETLKRIEEKIKINRQKYLKVLFGTRLGMWSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMZ3</accession>
    <name>V7PMZ3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_03120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="11">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="608"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="663"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB59703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1828" mass="217545" checksum="599535CD919CE823" modified="2014-02-19" version="1">MSNDIFLKNSKELQSVVVIDMNDEIDTARCFKFCIFFNFDNDFPNYKVTFCYDNKYPYSFPNINICINRILGEQEINFIILSIKKICAKNYGRIMLFDVCIFLNEHINKVYNDGFKNLWEEMRHREYDIDKEGKNKGNYNYEKQDKSCENHIDNNENNNNSKNGSNNYDEEEIFETSDEWDRTGIVEENMNMSGNDNEMTKSIKNNNINKKYPINKDDNNNNNNNDDDNKNYLEQDENRNNELYGSYEYFINMSDVNNLSGFSFINSCTLNKNIKISKKKKYKEKVNNIATVEDELIQKYDLEIFEKKRMVKCEYNNIKNFNIIKKIPINYYKNMLIAKHIIDTNIYIIHTYTILNEIQFLAFYLNHILFCNRGFNLFCNILNDETENQKKKYQRKKCKKNEKMFRAFLYDLGIIRNVASNEEEENSNPETINNIYNVDGNDLFNKKLRNIKTQNSQLFNNNENKNDTKVAPENSYTEIRTKGYATLYNYDKNKKKNNKIIDYNCVNYFCSEYQFYANKMCVVNRQNEKTLYSILKELNIYRLKEIINHYKIVQKMNLKKIITELAKLSKIQHKYLFRYHISWLEKEYVQLNDNMAQQTNVPKIIDFMTDFVLAAIGEFSDVCEKENAFTSHKKSMPNKGGEKKSINVENVINDKKSEQNKNMLILRDNVEKNETDNTTNNNSNNGGDNKKGGSSEDIKSEINLEVNNLDKIKYVEDLISKKDKNIYKVLYVQCEYCKGQLLEKEIENNLFQNNKYLIWNIFRQILEAINYLHKKKIYIKNLNTKNMYIDNDEYGSHIKIINYSVSNIIDYIYFYYYSYIENPDYFNNIFCEFRKYSYDNFSFESLFNYMKKIKNEKTMLNNNVSENFDKKNDFYIHSYNQYFYNFLNKKNPNFEELDIFSLGLILYELWHPPFKTIEDKFYNIKNMIKKRKFSDQFIKNVNNDAVKVLKYILINTINYENNEITRSLEYPQILSLNMNGYKKDGKGISKIKKLKKNNKNILSQPTYIIENKSDSKREDALKDSLNGADNLDVANNLDVADNLDVADNLDVANNLDVANNLDVVNCDHVFDNENVMGNGENIEKITAERLLQSPLIPMVIQRDLFRYFLEKLKNNSPSECNNVINSLLYNTNNCNNKNSNMSNHIYSKKYLFETNKNSHIYTNTRTYKYDIINSYIFEYFNDVLSKKFCTYNQPLVFQRVIKREDPNFDNIIKKIELKNGKKSYIYTKKQGKYGNKIKKKLYNDSFDSISKGIMSKKKKKKKKNEYITYSFDEHRPKNNNIFKTKDIKRINKNGKKSFVETDQEHDVDVYCNSFITETKKDENYSDKIMYDILNRFNNKLELIDKNNKLLYMPIYLSAGHINTFYNFPNNKNLISYFTFFQNYFIQNNKQKIAKRENSILYTNMIIDNGHTIKSSHNIKCHVFFKDAKIESVNLGSNVYEGKSGKDGKDGEDGDMYSEINIFFCIYQLIILYNVLDILQHFEWYINKLIVRWSFSNFLFIIIKDMFSIDCNDTVYYIYTKLEEGNISLKKLKKLLYCLDINYNEHILKIMYSLIQNRDNRNINNLSKDNLLYTMKKINKMYELKNHKNKSYINYIITNIIFLNNIFHHFNQNSNYIFVWDLFMNKYKQLFNFSFVYNILYFSENDEKLLSLGGVITNEFDNMNKINTKKSYNILFEIFVDNISTIIFKNIFKLKNENTFDFHSPSVVITTKTYKLLVHAFSLYNSLIQNNIKCECKISPIVETSKFEQELLKYNHINMHVQINHKVNTNPVVYFDYCENVSESITQNISGQNNISIIYSTNILRLNIKKNFENEPSVINYIKQLYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMZ7</accession>
    <name>V7PMZ7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_01939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMZ7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB60986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="194" mass="23956" checksum="88589C6688BBBA9E" modified="2014-02-19" version="1">MNYHKILGVTRNACKKTIREAYLKKVKLYHPDLNKSPDATTKFKQIQEAYQALYNDNYSQKLYDNENIYNQRTNSENKKNNKNYNNYNEFNDFHRAFYEEYRRMTKQEKHDEYARYTNNNSRYSINDIFHKYPREFFYINLMFKLFPLFVVPVIFLFVVYKQYILKSYFKEKPILIYDSYGRAFLIDTHGRKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQC4</accession>
    <name>V7PQC4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_01615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14884">
        <property type="entry name" value="MYSc_Myo23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="105"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB61801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1821" mass="216343" checksum="786C97A8AF34DCF6" modified="2014-02-19" version="1">MSFLHMKNNETFYHSNIPNIKDEGQEQLENDKKVFKDDLSLEKRNHEEIYSNSHVWYFHKNSYKKMEVLEFKKKEQLYTLKRKGKIFENIHKDQVIRSLKNELKLDNENNVDIIQLNEANVIQNLKNRYEKNKIYTFHASLLLAINPYKQLKDLYDVSIMNNYLCKFKNTNSSEKNDCKAHIYDIGNMAYKNMVLKRKRQTIVVSGHSGSGKTENCKFLFKYFHYIFFHKNSNNVGKIYKSMNSYVNDNSDAEQDEKVKKNISMTSTNISIEENGDMSRYERIDKLIYINNILESMSNAKTIKNNNSSRCGRINELIFEEKKTDKDIMFNHCFSNIKILILLLEINRCITQNDGERNFHVFYQTIWGLNDEDLNKRNLVRDVKVYKLLNNDVMKYKKGSTDNCDTKKIDIYEQNKQKDEKNFEYLLKGLNYIKYDKNKINHFFDIIAGIIHLGEIVPDDSNVTSNTSNHESSMENPFYRYKCACDCLKIHVEDLKNLIKYKNIQVSNENIKTPRTKENSLSTLHTLIKVIYKKLFNKIINDINMTNLSDKEKKEMLNSQIYENNNSIISILDLYGFEELSCNDFEQLCINLANEKLNNYYINNEIEKEKNIYKEENILWSDLVIPSYEDTIIFIEKIFGGLDDITKLNNCGHKKVDDNFFTYLLNNENKYLEKHIYGFLNNRDNQYTSKKQNIKKNKFFIKHYAGHVTYSINNWIHKNSDKIEAEIEDLINTSANVFLSECIKDEVTENYTTKSSEKLTESCKISNTSVGLTNNNCKKNNILSVSKKYIKELDNLFTNLEKTDMYYIRCVLPNERMECNNFKKGIVYSQLKECGANEMIKILNNGLSHKILKRELIEKLKNCIAKELVHCNDNDIIYYIMRIFDEDKFFKIGKKYIFMKAHLYTQINFYMYDSNIINDNSLVDRQKKKKILRDIRIMRFKRCVTVAKIFSWINNYYIKYLTKKKIMKEKICDYMYKIYLIRRTILSVKKSLSYNVKKLNKILCEKAYQMPFKKIKNTKKKKKNIINPLISITKKESVQHMSKETKNINNDKIDSEEKKEKIVENKNTEKITTKCEENEKNEKNPKINMLYNSGEKLFVCTPDNYHYVYNNLDWIIIYSKNKINFYNISYSYEQIDKKHILNYNKIGIKKIHNDTKCEQWNEKTNELNRGSVNYETEKDSKNVLHNIGKNNYCCVNQHPLYKNLIIGIDEELNIVLFSYPNINTIRRFIKKKIKLIKKSNDNLPNTYLPQLYKSRKYSEHFFEKKKNYLESIIKNEEMVNYDVNEKMDNESNLFDDNNLNMFIHMYKNIYVLSTLDGILSKSCSVNSEHFDNYKTMESVNKMESVNNIIENNNKEVKKDAKDKKCFTYLKALKKEDYISKELYTNETFKVLNISFLSNSINYFVYLSYALINENHYILLTIVNLFSKPIYTYTIHIAINNIIKNDDFVKFFIKNYNKIYQNNKIDIQENIEKQENTNLMKNKEYLDKFLSTIKMSIINNSHIFIYGCCILSLVEITKFNLNSGNPYIKEYEYKYLQLKFNLYCFEYFNNVYDRYMNKLSHDLKHKLIINDILGNEQKEDVEKKSKLVHLNISEKNEEHNPSLYIRNENNDNLFSQENENSGNSFYIFSLFSRIYLLTNKGCESNYSQVIFNYDDWKIFKLKLNSSNNNNNNNNIAEDDENKLCAFQGILNMNINYYYKQNYYKSHVSLNSSIQATIQKYDEYFADGTLHHSTHKYVYPDVYVLRIKNSNFTNSFDKNNNSDEESFYYNLKNNQMLRLCTHGNKKSSILKNRNCSPHSVLACTPLNHLDTILLLVIMSKQNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQC8</accession>
    <name>V7PQC8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_01918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQC8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="9">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB60962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="147" mass="16106" checksum="559B630D58C97244" modified="2014-02-19" version="1">MYNSWFEIIRGISPYNWALLGIALSLFLSIIGAAWGIFICGTSIVGASVKAPRIISKNLISIIFCEALGMYGVITAVFLQIKFSGLKTEVHSPLVLTPQTDPLIMNSIRGGWALFASGLTAGLSNLVSGYVMHSWKRTKKWPKNEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQD2</accession>
    <name>V7PQD2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQD2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="296" mass="34034" checksum="887ACED9936EF523" modified="2014-02-19" version="1">MRWHPDKHTDENDKLYAEEMFKKISSAYSVLSDERQRKIYDTYGIEGIKGNVDSFKPFYHTEYFNKIISPLKNFSFMTLINDKYNEISNFLHNIEYKPFSSSKTRNNNIPGSREITLDLTLEELHQGCRKEYKIVKNVFVGGTPFQIDKVLTIDIKPGLNNNDLITFHGEGDQVSPSSLPGNAIFKISTKKHDTFIRRGNNLIYKHHITLEQALKGFNFSVRSLDNKDIIINVDDIVGPNSKMIIPNEGMPCMDNPNNKGDIIIEFIHMYPETMSEEEKAALRDIINSTNNKNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQE3</accession>
    <name>V7PQE3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQE3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="8">
        <location>
            <begin position="738"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="669"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="855" mass="99939" checksum="A283140138771522" modified="2014-02-19" version="1">MTLGIDVSKLFPEIIMMSSTNDIIQKKMIYLYLNNYAETNSELSLLTINTLQKDSKDEDPIIRGLALRSFCNLRINNLFEYIEGPLFNGLNDKNSYVRRIAIISCIKLIKMNPQINIKNDVIKILKNKLLDKDSQCIINSVHALNEILADEGGLKVNKEIIFNMLNKISTFNEWGKCVILNIVSTYIPEDEDEMFDIMNILENHIRDYSTTVFLACLKCFLNLSANDTNLQIKIFNRMKEPLLTLITTSSYEISYIILLHSYILLHESNKLKYDIFDYDYKHFFFRYNDPTYIKDIKLDILVAVSSKNNVSFITNELSEYISDSNVDIAQKSIYSIGCIALKIPKSISRIVDLALCSFLPMKSPHICGATIKMLGNILRKYDEYTKVIIEEVIKHDNKLIDDVGIISYIWIIGEYCEYIENAPYILEEYVNLTDCSYIFMLELLTACLKVLYRRPSEMKIILVSLFQNILNNYKYPELTDKLFFYYKLLYYNYEEAFNIIASKKKLVTNFCESNENTLLDKLYNEFNTLSILYKYPINNHIRYSKICFSAVYDPEENTHSTNTYNDSGSDVAEACDTNKEHSHNMLYNNRELNDYTEQYDNVDCPQISHSDRDDVALHFDNNQNTNLININDDVAIVGNEISADENGDNHRNNIHNYKGHGESMYPIDNSPSAIKKNNHSPNTKNDNNNAFNSQYKNRNSDKMGTHPNNDTISEEKRTSLELLDMIDSDNFEKLKEILIYAENITPEQYQEQWNLLPEQNNEKLFLRKNYYNLQLESLDELISRYNIIILASGEIDQCLKFYMYSQFYTKHYVFIEFIFNKIEYSINWILKSQSDNADMVDQFTDCFRDIFIDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PRC3</accession>
    <name>V7PRC3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fam-a protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635732">
        <property type="protein sequence ID" value="ETB62131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PRC3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="29713" checksum="BB08465665043A45" modified="2014-02-19" version="1">MCTSLQKCYKYNNFIFVHIKNMFIFSYDNTKEIYQKNKHLLYTDPKETINAYKFMNDALKQLEHHATSKGYTRCGGIPSKNIVFYKKKHRGHTKILKAEYLIYDTNQYNELLNELWDPDCDQYINKDHVKKKIVRMYTPNLVMIQQRCKKHPWSREKYFYAIAAKYKISKNKAIFVMASANIIDHNRKNKKYFENKIVESANLFQAEVDSEDDIRNGKIKKTFVNLSGYIVEKRKDRIYVIYIDSMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSG8</accession>
    <name>V7PSG8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_01805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSG8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB62070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="128" mass="14991" checksum="5D0328A6A672137D" modified="2014-02-19" version="1">MIKGVLIINTNGKPRFLRFYDGSSHERQQLITKKIHEIIIKRSTDESCCFIENEELFGMDVKVVYRHFATLFFVFIIDSMESELGILDLIQVFVQVLDVNFENVCELDLVYNYEQINYILDEIVMGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSH2</accession>
    <name>V7PSH2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_01086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSH2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB62524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="258" mass="31038" checksum="934773EDCDC082F5" modified="2014-02-19" version="1">MTASDQEMQNNTDPIMDIITTAPSDSLYFIERINLISAIISISTSFPYLTYLFIYWDDCSCNDILRWWIVINSILQLLQAPIRFFLYLLLRKYKLENERMHIEALRRLTSSKGWKLSKRFSLLNYLWFITGTVVMVVTRKHTKNYYLWFISWTIILSCIFRVFFTIIWFCFFFPYHQNIPKKKKGVPKAFLAEIPTFKYSSDRRLKNESCSICLSDFVEKDEIFEFRCMHNFHTKCAKKWLSQRRQCPLCQRDVMKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSH9</accession>
    <name>V7PSH9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSH9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="109" mass="12971" checksum="266A3D37BF7CB972" modified="2014-02-19" version="1">MVQFFKKKNYRTANFLVKWTEYPKYSTINFVNTKKSCSYDSTSNEWQDFATFECRGIEIAEFIPSGDFIIEDTQGKIYYNVNLLDLNWCDYNQDHEMCVGVYNLEHEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTE0</accession>
    <name>V7PTE0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTE0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="158" mass="18424" checksum="B10D3908735462C4" modified="2014-02-19" version="1">MAMPLNCLKKTHGSLPYNINHKILGNLYKINTNATKNGIKTEIINEKESYKLTQNIDPGNIEYKYCSYLKPMEIKGIKRADRKFDYNSSYVFMKKQNDFKDDLSKASLLTKYLYNGMKIPLPPKRYKLSEYVDVRIDMFSPIIVCSVICLPFFFTGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTF5</accession>
    <name>V7PTF5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTF5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB61902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="201" mass="24032" checksum="D9955F2EEDBE2AB5" modified="2014-02-19" version="1">MELSVKEKKKLLENLKHRMLRIEKVIGDITFYDKNNPLKKNNSENSFDNKKNNLIEEFTQSSNQFDDFENLDEYKNNLDQIKSSLQNLSIDFCDEKKKNELIEIVKKHKHNNSISVHICIIKLVLEQISKDFLNDVYNQYKEFYIYIHSSSILDVYSAFEYKRNIILSHINFMKCYSSQIKQTLELKDYINSHKISGYRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTF8</accession>
    <name>V7PTF8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTF8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="467" mass="54859" checksum="33FA1AF221815869" modified="2014-02-19" version="1">MDKLNKEHIISINVGGKIYMTTLNLISRYKNSRLYEIVQDDINKREIFIDRNGNRFEYILDFLRDGVLICENDITVLTRILIEAIYFKLFSLMKIIKKKINLLYSNMNNNVNKNIFKRIISTIEKNRKEETNKLVKLSGIISNYNELKYFNLKKKKKKSYITILNNSNIINEINQVNKDIEQVFARPDKNDSTNLLSANFQKNESTNKLNLQSVTNEKERKKTNAYKESYYDTNINSEKNMNSQEKNSNIYKKSESPNFEISNKIEREVSKDMLNSNLKNDVDKMDSHLSDTNSLEKNEKDIHANSEYYNAKTIGHKYVSFSGENDIIFYTNSETLSDEEQFGNIKNSKDEKEANSNSKNISRLRNINVINNKVSELNYNNYIGNNDYIGYRDFENEHNNFPNYINSVCNKKSTYNYNNYEYNNMKNNVRNPIMVYSEIDDVEETSNYPIMPNINLGEQIFSTTVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTG0</accession>
    <name>V7PTG0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">YYC_00538</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTG0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="63"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="473"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETB62909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="955" mass="113034" checksum="CDB30370B7EFC8F3" modified="2014-02-19" version="1">MIKLITIFVTIFITIIFYHYFYCHYFLSLFCSEPEWIRENIINNVIQKYQNYINMEKTKNENNLKILNKYFTFTNDKIQFNEHILLQKKQKKNDIIQKGEDNDDILPTWNDEDMENNFFLDEPPKKQIFICSRTQSQLNQYFSELKKIEKKLSKENLPINMIIIGSRKHLCINEKIMKKCPNVNELNEACRSSKCKYKEGFTEMVLEKKKKKKKIFYESSSDSNSSKEENDEINNYILIKKLINTKNIDMNKIKEICRHDKIEICPYYMCKENIQNADIILLPYICILNEQIRNNLKINIKNNIIIFDESQNIIENINNANSIGISKSQIIFTKLVLKKYIQKYENSLNNNNVIMIKQIIIYCDLLLKYFTSINESVSNITRFMLLSKLDALNLNNISAFLNNSLFCRKFKIFAEVNINEYFKKSNKERPSIISAYVNTSSIYLLCEFTNKLIRSNKYDSIYINKNDDNGIYNNSDLEDDNQYNNKTETLNTNNNSNTGGSNSSCSSKRPGCSTDNNVEAEKKRKLQNNTNVIGTKNKNEPNNSNDDFSDLSEYLKYILENIKDMILKEKIEIISVSSCNNFQNITKDCNNIILIGGTLQPIEEFLLLFLSEKKNKIKLYFSDYIFKKSNIFVRIMPTNLLTFNSIDNTYKNRFDRSHLLNIALQIYILTLYVNYGNIVFFSSYTFLNEFMNFLYNEGKYILEKMKKKKFLFFEKKNDNNVLKNYMTNIINIKKQDNQMRIKNGCILFCVMNAKLSEGINFHDDFCRNILIVGIPFFKHEKNNTSTSNINKNNLVLNYYKEYSKDRSKKNDPNTHDISNSIPILSDWQISQMCKTYELKCAMKIVNQCIGRSLRHINDFSSFFFLDQRFNNPEIYDCFPTFVKTHLNDIKNLGYTNNEIFQKEKQNFHEIYDDIKNHYKHIITNQDPIKDSQNYLKNFVTDLVHLKEFHKKMNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTG1</accession>
    <name>V7PTG1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_01313</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTG1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="11">
        <location>
            <begin position="147"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB61413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="246" mass="29463" checksum="4D1EA55DE228F848" modified="2014-02-19" version="1">MDDNFIQNSRKKNQNVENMNKINSIISHMELMNNNLKNIFSHEQIFSDHDSYLLFRGKISKRIVDYSQLISNCNDKILDCEYLEDDNEKRIKDTLEEHLKNLENYKRGLSIWWRKNEKDFHCLCMNNFLNLQKSDSDIISTDKKTDNKSLKDTKKIMIDEINRMKNVRSELLESSQKLKKQNEIFNIFEERLRSSANLIFSLKKRADNDARYVWYSFFLFLSVCGYIVMRRLGFIRAIITVNMKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTG4</accession>
    <name>V7PTG4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTG4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="445" mass="52392" checksum="F8AAD8E48059252D" modified="2014-02-19" version="1">MLFWYFLEKLTNISDLPNDINKREIFIDRNGNRFEYILDFLRDGVLICENDITVLTRILIEAIYFKLFSLMKIIKKKINLLYSNMNNNVNKNIFKRIISTIEKNRKEETNKLVKLSGIISNYNELKYFNLKKKKKKSYITILNNSNIINEINQVNKDIEQVFARPDKNDSTNLLSANFQKNESTNKLNLQSVTNEKERKKTNAYKESYYDTNINSEKNMNSQEKNSNIYKKSESPNFEISNKIEREVSKDMLNSNLKNDVDKMDSHLSDTNSLEKNEKDIHANSEYYNAKTIGHKYVSFSGENDIIFYTNSETLSDEEQFGNIKNSKDEKEANSNSKNISRLRNINVINNKVSELNYNNYIGNNDYIGYRDFENEHNNFPNYINSVCNKKSTYNYNNYEYNNMKNNVRNPIMVYSEIDDVEETSNYPIMPNINLGEQIFSTTVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUJ0</accession>
    <name>V7PUJ0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein regulatory complex subunit 7 MORN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUJ0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033551">
        <property type="entry name" value="DRC7/lobo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056291">
        <property type="entry name" value="MORN_DRC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35249">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35249:SF2">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24667">
        <property type="entry name" value="MORN_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex subunit 7 MORN" evidence="1">
        <location>
            <begin position="315"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="676" mass="82058" checksum="81CD5299BC68656F" modified="2014-02-19" version="1">MLKYITNNKDEIIKNYNDIQPSNKETVLLNYLGELKKKLKETYTINFCEYFIDEYGMKKNICSSIRQIYFPFNEGNNYKEIYTLIKNYFTYEILLQKKIKTLLMASTPLVFNWKIADCLDLSCIIVSALRTKNYEAYVVCGEAPFSICSKDDKKYICEFTHKKYKEAQGENINAIDIREKKKKYKLVLDIYKGWINEDTFKDDSPEYENDFYVHMWILIKKSLDVDKDIFIEVSSGREYTIDNCPYKSIFYLWNEKNVYININKVENIDILVSEIKNKEYFIPAFFEEIKNKALIPIIESNPYIIRKDIFLLKYPQGRKTTFFKNCKKDEYIDFLQYDGLTEMHTHYSNRFYTSVESVCSFYKHRRDKKIKKIYLPNKFKTIEYYDESNHHLLKRFANRIGFYLHFTFYLTRYDGLTNYIEIKDYKLIEYFINRNDNVIYRSMNISRDVKTTYKIKTFDGNEYYVTKITLKYRNKNQTNGIKKKVFLIPENKIILVYYNNYNKISNIFQVYEKHIIYNPDIEKDEEVVLYKKNLIYKHFVNYGEPLENETNYLINEERDVFEDMKNTYNNIICSIMKEREEIKKTEDDYQYSTNNITNINEIIYHENNEIEFFNKNIMKDNLNVYNFYKDYPWNDYTQVSMKNTFFSSKNKMLEIELMRDEIKYISLENKINKYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUJ8</accession>
    <name>V7PUJ8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_00909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUJ8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="661"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB62307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="904" mass="106346" checksum="D74BBA660866496B" modified="2014-02-19" version="1">MKTCKILKKKKNGKEVIKGKNKANKTGDKKTIKKKKEKKKKMNKEINISEEENSTIDNPQHFSDTYSNSSFIYEKKNKKKKKKITYDDEENQYASTKFISFLKDYNENDGEKKNSKKNKKNNKTNKTNKTNMDNAESVESGNDDDDDDDNDDDDNSVYNYLPQNNDIYKINGNGETLDITDLIGSGDNILEKNIVKDIYSLKYDKKDKNRHISVLEEQKINSQMIYIKNVQNLNRINKSYNVIQNSWRVMFGKNKDDNNINSEEYINKNLLKRHNNLSAKNVEKSAEKNVEKGAEKNVEKNVEKNVEKSVDAEKSVDAEKSADVEKSAEKNVFNFEEEMKKNLEKSKMLIVSDDILKNRKEKKREQSKKISQLKYLLAMERKKHALRKHIKSKSYRKYLRIKEKKEHEKMWDKLYSEHPELAINIRNYEDEYAKKRNVINNVKKKRKIFNLLNRYKNEELKKEMLKSFQIDKEEKNMLKKIVQKTAIQQDIGEDEYSFGNANSKYQEIENNTISNNSETDEQNEEDSIDIENERAKNVKKELKKRNLLRFSFMKNAEEKKKNDQIYKKRKQLLEKAENKTDENDSLLNSSDDENSQNSQNGQNELSLVEDTEISKLSSKQVEKAKLQLKEDIDLGNMLRKNAVLNTNNIINLDFEINENEIEEPDAKDVENNNTEEKDDEKTNSEKDTTDEKKGKKKGEKKGEKKNNKKDMIDEKQINDLVDIDKINDEDVLKQYGEKLTVYNFENNIYEDYININDTINNREDEELFELSDSEKITGEELNVNEWCNYNTLIEREQNIIKKEKEIIEKKKNMPLHTINVLNKKDKKFDVYYVDKIPYPYEKNEYEKSLNININKEVNDISTFNKLIAPQVTNKVGNIISPLVHNPFEIASILTLRKKKNKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUK7</accession>
    <name>V7PUK7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc-hook domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_00129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001805">
        <property type="entry name" value="Similar to DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75712">
        <property type="entry name" value="Rad50 coiled-coil Zn hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="9">
        <location>
            <begin position="653"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="599"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="705"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1162"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB63299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1595" mass="190543" checksum="85A68628F027FC4A" modified="2014-02-19" version="1">MKEIYEESSSELEKFSDLFKTDLIKCNELIEKINDEIIKLEEESENCLNAYACGNLKECSEISDSIFCLEKKEKQLLDMIKNIYDLDICISNNFKCKCVRNILLKEHKKIILLAQNSFHTLTFIKSVDISTRKDELISNCDWNEISSMKKEDSGNSKKCITNRGRMIKKINLNFLKDLDLNSYQSFFDEYKEFEKRHKKRIKKIYNFIRQKKIQSRENKMEKNKNKNILKIKKYQEKLRKIDKKIDQIEKYKKQLILLKSNDDIYDKKFKNLEKMFQLKNIYDTIILNRYDGCNDDNADNADNDDNDDDDDNDNDDDNDNDDDNNICTFKEQNEKNIKKKKLNEIVNLKNKLNKVLIYITNVNLLCEYFCDFEKINKKIIFFFRHLFLYLSQMKIFLKLCNGIQKKKNLYDCIKRLGILDFEENEFYSNFKNDNSQMSIIMSKIGEKKETDKMFIPMIHNNLNVKKEEDNWHTFEEKTVKLENKIEKNTKLKNLISLENITNCVNKNEDILSDNLIKLESKKRVTAHFEELENGMKKKQRQEQDKFETVQKMKIEKIEKISKIEKINKIEKGENETDCETKLEWSQEMGIVERGLCEYAEKYEKKIEEYNIEIKKIKDKIVAKSNETIEADKEMKNCLENIKNFKGMLEKLEIKNVSNFLDIFYQTIKKIKESKRNLNWLTRKKDEKIINIDKINGSKFCNICKHNLEENEMNKIKTDLNNEIKEIENEIEEENEKLNNLKKNKKKYLPLLKYYYNYIHPISNQINNLSENKINEIKNDLTNLQEHLNIYLNKINKTNEKYKVLHKILNIYPNLINFKREIVKHAKKLFLCKDQIKNVLNFFKEHNSDNYDTLFGKNEFYNLGGKFAKLMENSDDKDSSKETTNLITKLKEVFEMFMRIIDKKEYFKYITNIIEHNYDNILCTFSIKNALLFINNDDNIYTKTNSFFFSKFMKLLSIEIKEKIEQTIISNSGVDTNEDTRLENKEDVEREKFNLKYGDKENDSKDFEIFFNNEERYSLINKLIDVEKKNKTIEKLCNELIVYIKKEEIKTEEEIQMLCRMEFLINDKKIYVNKKIKELEDFINKENKIKECIKKTDIFLSYYLEKKKEIDKFINFNNVLIKKYNKKNKDIKKKIINNKYGILFENKNYFLKSCIINTICNNLKLTKSEKEKQESNLKNIREQISNNELIKNESNEIINKIKKKKEQVLCLKEEKINIEKMHHNVVINTNLKKIHETFLKQQEQFLELLSEFRENVLRRKRDVDVITQNEINSSDNIDVTIKKKIETEKNIINNQINEIEFIIKTFQINYQSNVDIHKFLRDTFDYLMYKKKLEKIINTEKEILKSKIEECKKCITDIQIKEGELQGKICLRNEYVEKLKKDIKSGSYENIDNEYKKKLIEICVYKNVIKDLSNFHNSFDQAIIKFHSLKMQEINLSIKNLWRRVYNNPDIDYIYIKSDLEIENNEKINQRRSYNYRVVMVKDNCELDMKGRCSSGQKVLSSIIIRLALAESFSIKCGILALDEPTTNLDKSNSKNLANLIANIVDLRKNSSSFQLILITHDTYFVDALSQYGLTNCFYKVRKDRNGYSQIVKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUL4</accession>
    <name>V7PUL4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_00132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUL4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="91"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB63304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="526" mass="63044" checksum="EF9C96BA4389C64F" modified="2014-02-19" version="1">MNYSFCPFFLHKQYIYACIRAYLSIIYLYIFLLFLFFYFFIFFFFSVTNEYIQNLQNFLGENQIISDQKKRLVDFQNELNEKNKKFDVFSKIIYMENIPEKYTENDVVEFFKNVGKTTNYKFLYNEQINKHTVYVEFINEENAKAALNLNGTKIEDKEVIIKDAYSILNQNDSTLKTQLSIYNNLNKTINNDKNIINKKNTVNEKVEKVLALKEKLTLKLCAMYNPNVLLMNNLMQSNQLLLANPLNNISSNNNIKKEKEKNDKNESDLTISQKEFKSDDKKNDDKKTDVDMSDDEKKKYIKKKQKKNTKYSTNSHSSHTTEESDEKKSDQISSKSQSSKSRSSGSSRSRSSRSRSSRSRSSRSSSGRSRVRRKSIDKRHSSRKRDKIKKRSPSSSSNYSKSDPPSSYDSGKHTDRYKYQNQRHKKKRRKNSKGNYDSSDTCSHSSHSSKRKHRKSNSDKPWWIKESEKMEMRKRMKEKYRREMLYRHKHKEKSRYRHRDRDRDRDRDRDRDRDRDRDRDRDRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUL8</accession>
    <name>V7PUL8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUL8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB63309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="106" mass="12390" checksum="75577C7F7C67B5F0" modified="2014-02-19" version="1">MAKNRLLIESREAKKQNDPDIFLSHSDYNLYEWEAIIKGPKDSPYEGGKWKLSIKCKSTYPIDPPMITFITKVFHPNVNFTTGIRVNKYIYIPPNFGYMSFAHIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUL9</accession>
    <name>V7PUL9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation elongation factor G, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_00096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUL9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04088">
        <property type="entry name" value="EFG_mtEFG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001532">
        <property type="entry name" value="Translation elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="105"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB63261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="872" mass="100500" checksum="53C4C7ABA4E17DC2" modified="2014-02-19" version="1">MIKIFLSKSYKGLDRFILVLFLIFTIVGANGLNNKKRLSQCKSIFKHNRGGKSEGIKLFIRNKYFNKNNDLLSKYRRKCNNMHKVNIFRLKLSNNHSLKKNVDLENYRNIGIIAHIDAGKTTTTERILYYTNVIKKIGEVHEGLSTMDYLDIEREKGITINAAVTTCYWNGSEKNLGNYRINIIDTPGHVDFTAEVEKSLRVLDGGIVVFDSSEGVESQSETVWKQANRYNISRIIFLNKLDKVGANFESCIEEIKRKLNKKILILYVPVFEMSNFITTIDILKEKMIVYKNAHDFYFEDIPQEYYGIFLKYKNLLYEQIAENFNAFLDNYLNDKVMKVEEVEYYIRKLVVEQKYNVVICGSSLKNKNVQMLLDMVVKYLPSPIDCIQNYKNQIIYKYDVNKKGEKIILNSKKDEKSICEKMDNVSIGNDINGGVNSETNKNVTSGSNNIYDESVNQVINHKAISNTLNSNEKNEKDELKQNDLISEELSKENIKDYNRKFVGLIYKIMNDQHLGNINYVRVYEGKLNKGDFIYNNRTKKSEKVSKIFFIHSSEKYELENAYAGDIVGIVGLKDTQIGDTISNVFLRTELKKIKEIPPIISFYIYNKNKNEYEKLINALIKIKKEDHSFFFHINPDTKDLLISGVGELHLQIIINKIQKDFNIPIIYGQPQISYKETFIENVEARGKYIKQSGGRGQYGDVHIKIEPMYNYTEEEDKEYDVNNNNDDKKEETNDDMDKNCMNIDTSEVNNNIIIKNEITCGAIPSVYFDAINAGIREQCNLGVLSNSPLINIVIRIVDGSFHPVDSNEHAFKLAAGLAIREAAKKTSVRLLEPIMNINVTVPTEYLGEVISDLVKKRGKIQHIDESKFKRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUM8</accession>
    <name>V7PUM8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_00141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUM8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052298">
        <property type="entry name" value="ZMYND10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244:SF7">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="422"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB63319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="462" mass="55312" checksum="CFCB98116BD07B0A" modified="2014-02-19" version="1">MDIKDIEFFEYVNNLKNIELLDMFSTKWFECHKNVVLINVYLHNNNELIDVVGDDKMSHILTKFEVLLRELITTYFIRFLNFEEKIKKNNKKTLQIDELKNKNIDTENSHNHIYDYISLYHEMAVLNIFELILLSDHIYEQIDTYIINLFAYIYSNLVSFLKTSSDEYFVKPITELPISEILKEENDKTHNIDRLKIYINVINTLRNIIDRIHLLNNTIVNKIVDYDILLILIPLIEKKPWKHDNYIFEQNEWIKNEDNAMATVEKQLWIILYTLILNSICQEKYEMTNYRRNNILKLRKYMNENLYEQLPPMKTLHTFIEHLYISKSVFPENKNSYLIIDVVPEIFDEIKNDILKNKKQVLSMLNNITISKEVLGSISEVYLSVYEFDHQIKKSKKKTKEINPIDTNHGEKEKPIDNQYTCNSCKEMAELQCSQCKQAYYCSKECQMKDWFSHREVCSSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PWP6</accession>
    <name>V7PWP6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_00639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PWP6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="7">
        <location>
            <begin position="232"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="6">
        <location>
            <begin position="1004"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1061"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1105"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1065"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1120"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB63042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1169" mass="131707" checksum="8EECC5CD5AA83169" modified="2014-02-19" version="1">MDVEKTIHENDIVTSASGVIALLNEEDASLKIFGLEKLNSVVDIYWPELADYIFKIEELCEDDEFSGKELANLVASKVYYHLEKYPEALKYALCAGKLFNINEKSQYIETMLAKCIEKYVEIREKNYEGVDSNNSAQNNIINYSNNENSFSGSYTLNNNYNNIDSDYKRGKGGLNINNNIDNNDDNRNVYERHNYSTKGVNANNIAKNNNNILIGDNENDNDKIKDENNIFKDDLNNDINKKMENFVDDMLEVCIKNNSIKEALGVALDARRLDKVEYIILNAPNKLEILQHSILNERHINTTKKFRKDFFKLLVKIYLSMSEEEIKYEYVNLCECLFYINDYKTVAEILLKLIENYHLMVYQISFDLVDLENINFLKNILKEIKEIIIKNKSYYYGEENYKHLNADLPKKNNSGNNSGSNEDASGQDAPDQDNSEGKDQTEAINDGTDPTVLTSVAANADDQENDKKDDKDGKNDKDDKDGKDGKNDQNDQTEEKDKIPEDVLIYVNEKHHLYEKIKKLIFILTGKITTSLYIEFLHRNNHADLILLDNYKNVIDSRSSITHHGIVIAHGLMQAGTTCDVFLRSNIEWLSKAVNWAKFSSTASLGVVYKGHVNQSFTVLSSHLPYNDISRQITNNINANISQNDVYSESGSLYALGLIHATYNTNYKKVRDFLLSQLKASNNNEVLQHGCCLGLGLVCLEQNDDEEIYDELKSVMYSDSAVSGESAAYAIGLLKMGSGDEKCVDELLAYAHDTQHEKITRACSISLGFVMFQKEREADNLIEELINDKDAIIRYGGMFTIALAYCGLSNYNKHIIKKLLHFSVSDVSDDVRRAAVIALGFVLCNTPAQVPMFLNLLVESYNPHVRYGAALALGIACASTGNEEAVNMLMPLLTDTTDFVRQSAFISLGLIFQQSNENISPNFKKFKDEIMKILSDKHEDIIAKFGATVGLGLLDICGRNAISTFFTRRANIIRPQSAVGFCLFCQLWYWFPLIHMISLTFLPTCLIGLTEDLKVPKNFTVLSAKNQAFDYPSFLSKEKIQEKKETVTAILSTTDKRKTLKLKKQKNENKLSKEKNPQDDSSSVLSDGKSMKNLEILSTAATIGQSSHVSHAESVEGSANGENSNDQQNDATQFSGLQRIKKSDKGKAPSLPPTNNTVSGFHFGSLWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXN0</accession>
    <name>V7PXN0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXN0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="144" mass="16866" checksum="344C4AE390527F35" modified="2014-02-19" version="1">MKLKRIVHLQYFIPKIFRNIFNIDGRGIAVEDIKVNLKKKKLTIKTVNYTLAPFVNSVEKCTYFQKDGYDNNTFYKQSTQINITGLGYMKNLIENTILNVIKEKSKQGIEIMDEVIKRTMNENIKINQNNIYGNTLNKIQNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXN9</accession>
    <name>V7PXN9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXN9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048478">
        <property type="entry name" value="LSM12_LSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21166">
        <property type="entry name" value="LSM12_LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="78"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB63397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="178" mass="20926" checksum="79C148A44DCCBDA5" modified="2014-02-19" version="1">MVKNNIDPSLYFGHIIATKTTSGDIFEGELYCYDTCLNFIILKDDNKNGTANFYIIRMHTIVDIETKQKLKTLYEVLPKIDKAIVEKIERKSIENFEKKKSRIGIRVTHEAQELFDFIWKTHPDCTWNNRDILVLNGEVRIKHPYGPDNCTAKNEKLRERFITVISRFRQKKAMANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PYT6</accession>
    <name>V7PYT6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein associated signal transduction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PYT6"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="7">
        <location>
            <begin position="439"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB63333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="75827" checksum="5298970735FB420B" modified="2014-02-19" version="1">MKFAEKLKHLKVKSWDNKYVNYKFLKKIIKKKINPEIKALYDRIDKNDEQILEVCKLVNLDNTLLNQKDKKKKNEIENEEIDYTYLFFYVLQNYINMVKEHYESEYNYLYEKIDEIVFFLESDRVNLKDMESLKNKCLNIYNLFDILTNYLNINVLSVYKILKKKTKKERLSTSLDLYQKYCNNLHQISQEEHFNEKIKSTFLLIQKKIGDNCEKIDFLNFKIYLKSKIENLGQYRGTIFILCGILITLIINTIILLYLNINEININRILSILPIYRLIYVLNFFFLFIFGSFLFMQLYGVNFTYILDLNKKIVNEYYYLINYVIFLLFLTTVSLLIFLLDVLFNLNIFSNIILHVVILCILLVCTTIFPFNFYKYKENNFLFSSLSRVLMSGVFLVNSVNLLDNIMGDILTSLSKTFSDVQYIICFFLNGMDTTAPAKCPIIESYVNPIFVGLPFYLRFCQCLIRYNNERQTIHIYNMLKYVSGICIVICTSFNWGYLGLDIYTSKIILICAYVIGSTYMYIWDVYCDWGLLKEYNYLLRKNDNLMYPPQYYYFAGFFNLIFRLTWAITIMPINIFPNKEINFFLITFFLMFIEVLRRSIWICFRLENEHVTNASRYRAILWVPKMTKTKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>V7PZ38</accession>
    <name>V7PZ38_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PZ38"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="110" mass="12705" checksum="77B55983F4C8847D" modified="2014-02-19" version="1">MKYTAFKNSLRFASKFCQNNNYKLYMNSVPQFSTYAYGKYLKTNPLTNRLDDLLKKNSNLISIISLNGLDDLITQSSKIESVSIADWLLNLVEEYQLMLSCVNMTTIRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PZ43</accession>
    <name>V7PZ43_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PZ43"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB63443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="53" mass="6339" checksum="13DAB1C4C0CFABF8" modified="2014-02-19" version="1">MCAGTAIPLILSAMSLCYINIEKESKQIHSYNNEYRKKQRENMKIEQRKYEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCB1</accession>
    <name>V7PCB1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_04912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCB1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="6">
        <location>
            <begin position="839"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="545"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="551"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB57064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="99950" checksum="FFC924FBDDD42F75" modified="2014-02-19" version="1">MKFDDCKQRLSNMISALSTTIGDENNIVKYIIMGNKKDLINYGHEYIKNLTTKLIVEYKNIKDEETVQNQYYANNAITATSISTSPISGTSKGGSANMINHIHELVNIIVPYCFNHNTEYEAIDLLIEVDRINDICQYVDDKSCERSILYLLNLTHYSSSTEEYYKLMEVILSILKKHKKHVECLKILLRLNRRNKIKELIFECNDLLICKQMALICSRHCIHLEFTQEEIIKYPHLNLNEISTLSSGEHLPSIFLKLAKDLDVEEPKLPEDIYKTHLEEKRNTNVWDSTKQNLASSFVNAFVNAGFCKDKLMTVNSSLWIYKNKDHGIISATASMGLLLMWNIDEGLSQIDKFQYSNDQYVKAGSLIAFGLACTNVKNECDPAYALLSEHIDAENSLEKMGAILGFGYAYAGTNRENMLDVLIPPLVDNGDIIECSVFAALSLGLIFVGSQNREIAECIIDTVLERQKINNSLDQPISKLYAVALGLLFLCSREKCEATLAALEIIKHPISKYIIATVEGMAFAGSNDVLKVQKMLQLLVEKRGDKKNTDTAPSVNPPTSDTNTGNDTNVGANSGDNEGTGNNNNNNNNNNNNNSAPDSKKTNNTNTGKNAKKGPDGKPNISNSTNNQIEDNLDQCVAILNISLIALTDDISSEMTTRIIDHFLEYSNVHQKKAVPLALALLFTSFPKPNIVDILSKLTHDQDPDVALHAIISLGFVGAGTNNSRIAILLRQLSTFYYKDPNATFVIRLAQGLLYMGKGLLTINPLHSSRSIISHVALGSLLITIHACLQLKYTILGKYHYLLYHLAPCMYPRMLTTVNENLEPLPVSVRVGQAVDIVGQAGNPKTITGFQTHVTPVLMLHTDRAELATEEYIPINDTLEGIVILKKDPNYVPPTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCB2</accession>
    <name>V7PCB2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCB2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="445" mass="51788" checksum="73E3DF1E009B1838" modified="2014-02-19" version="1">MSSKMETPKDLSEMTDSDFSNIEDKTDDKNEPSEQNEKNEDEKKNKKKISLKKPKKKSSISSKTSQKNNKKVIQNKTKKKTNGLLACPPPPTHPPPPPPPPFIPKEKQQNWKLKKKTNNSDINNDIISITTYPANSNNNNNNNPHYRINEPHMYNKSLSIPSIPGPTPPYPSNIYNHPVSNINSPPCTNTNIKVNLQTNHNYNNNFKKNYKINNIPESESYVMTSPTLISSSAQQTNTPMNIHVDRKHTLISNNSITQNKDYPYIDIQHNNNNMLSFPSSPKQPYSNISIPPNPNYYSPNNLRPTDYIEDKIYYPNYQNNIDHNNTPKYYQPVVNAWNGAAPPPIPNNPYQGNPKFSPHDYNPEKMNYKDKPIRMDNAPYDPKPHNIIITNVNTHYFFFKKIKYIIYLFIFFDLTQRVSYYVHIWNINLFIYFINILFSYRYQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCB4</accession>
    <name>V7PCB4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635824">
        <property type="protein sequence ID" value="ETB56412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCB4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004763889" description="Glutaredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18889" checksum="25D8AAA8CAE7E5DD" modified="2014-02-19" version="1">MRKIIFLIVIVLSFLGLIQNKGRTPNRNSKIKRLPVIKDSTQLISIIDKTPTKQYITYVYHSSICSYCSLITDALKDNEHVKMININEDSKLEDLIKTDKPIVVILKNINKEESVERSKFYYELQKKGGKVRVPALEIDNHIMYESKEILAFYKHLLSKFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PCB8</accession>
    <name>V7PCB8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_05565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635824">
        <property type="protein sequence ID" value="ETB56417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PCB8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB56417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="441" mass="51923" checksum="BB7CE3BA1166E49E" modified="2014-02-19" version="1">MSFFQPVELIRKRNVATQDFKDYLFQFKVVKRENGNSSIKSVCIWKEYVVIGYNNTVSLHNIKGEWLQKKYSCKENVSFLKFRDEKMLGIGMENGNIELIGVFFFDKIKNLKGHKSSITDMCFSSNFQKLYSCSRDFTIKIWNILEAKCEDTLDYHIDSITSMCMYIKNEDNYLISSSYDGYIYFYNLNKNESPNKLELKSPIEYIHIYKDKYIFVAVKNVIKIYSLENFDFIKDITITAKTIYFLNSFNKYIVAASIDKTVYFIDPQLKHPEKIKVVSIFTTIQPSKAVSMYENTICLGSSMGSWSIYGYCESEKKTINNKRKHSIINLEEEKYRITNKNINNYLKRFKYNDALIEAITYESSSMLSLIDYLSKQNMLFAACSTTCEERILKILKFFRYKFVIDILMFEFLFSFLSANKWIETSKNKQILDMLQDLKIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEA0</accession>
    <name>V7PEA0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_04688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEA0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="37"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="875"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="375"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="822"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="888"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="950"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB57896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1217" mass="141022" checksum="142B38BCBA1DFCB5" modified="2014-02-19" version="1">MKNKTLDNNYSNGDVNNPKPNYFIPSKNDMNNYSNIYEIYVRNLHIDITKEEIYTMFEGYRIKRINILNKKGKTAAAYIEFDNAEDMNRSLELNGKMLYSGNNTFEHGTISVIINKDKTKAFNLNQKQNKFKKTTNRNNNFGNVRQGNNIMNNYNNNNNNANNNGNNNMNGNNMFSLNNNSFFNDNNNNNNMRMGMKGGNDNLNSSFSYNNMKSNYMNNQQGINNMNQSNNNMHSQNDNKNSNSNFAFKNMNYQNKNANANANANANANANANANANANADNTTATPEQRKKLVLKKRTVPLDQNSYIANPNIFGEAKPVDTNPDKIISESISKEKDNNSGDENNNSNELKFENQEEEESGMKMNNENRKGMIRSNSNKNVFNYKKNNNLNKNSNYNNLNKNNGNSNNGKNSSASKKNIFMSNKNNSGNNTNINMKNNMNNLDNSTNLSGNINSIGSDTNMKRMNMNKGFKNLDINNNAHENKGYNSNVDAEANLKSSYNKSLNYMNSYNDSNGNSNGNSNGNNSKNAFSTLRNNLKSDKKNEDGLHLTKSKDLNIIKKDDKANIKNIIMKNIKREDGNNKNSSNIRNHSIISSAYKNSSSNNEDGQNNMKFSKNYNKFGSDNETINKDNHNLRKGNENNSKKNEDGFENMNRNIIKGSGDGNNYNKNSNSYNYNIENLYDNSLKYVKNSNNSNKAKKLTSVKTVKVITTEKKNEEEHNKVFDSKDKNKDDINNDIGNGNSNYGNNNESNSNNKYYEHDNKKIDNNYDDSYRSNNDNYTYESESSENAKDITSKNLKSTLLQNKTKKKTKKKINNNDKEENSNSNNNNNNNSNVGDENNTQKNAKTQKIDILIKPNLKKGENIWEARTNLLGEHNENNNIIDNDKHSCSHSRRSRSHSNKLSRASSKRRDSSVRRRDRYSRKYDRRENRRDEKKSDRKDERRHSRRDRSRRGESRRGESRRGESRRSERKDDKKDDRDDRDGRDERDDESRMGESRRGESRRGESRRGDRDEHRRNYEKRSSRSNNYEKRRSSKYESVDKKTYDSKEYNSSDDKKKHRDSNDKISYKETYDRLSYNENYEKNGKDNNYRDSYHRNNNYIDYEKMDNKYFSNNYNSIRHKNYNNGNKHHNFHSKINNYSYSNNYKSSNYYNNKYPSKNSSYYKSTKGQLKINEKEKSESKSEIQVIPKKAIVSTVKTNNVSIKKNRYECLDDGDESDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEB1</accession>
    <name>V7PEB1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fam-a protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEB1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="26952" checksum="B7983C0F7A14D8A9" modified="2014-02-19" version="1">MEKVVAQFLCYTNNKDDYVLSRKYDNDAFLYLMRHENHTNIEKLNIKFHNPNKYDEIINTLWNPNGNKSFGYTYINEKVARVYNPNLIMVQHRLRSDTVSLQGYFYALAIKLELSHGVTVIVYASANINDHNRLNQKPHRNPVLEDTESFTAEIDSESDIRNGQITKFFVNISGYLIKKKDNYVDLTYLNSVNNIIVLFYYIFYFYFVVYILKFIKNVYPMCKYAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEF3</accession>
    <name>V7PEF3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VTC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_05112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEF3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="VTC" evidence="6">
        <location>
            <begin position="255"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB56723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="698" mass="83773" checksum="4B280D9B2973ECD7" modified="2014-02-19" version="1">MLLGIKMLPPFLYNDIISHEIKKVNKFSENKYNEIIKNLVEVYKELKKIKCNSELLKNKKDIEKILDLIGCDIIHFDFYIQKNFKIIMKLVFFFDKIMNISINQWVLLSLIKEKFCNINIENLIVYLSFLYSSLRLINNNEVNNKDKNNQIYNNQNKNNETWIPPDTFERTSNKFLVKLDHIIYTKVKIVKHLPYLIFGLNNDDIEQHFISLIEKEEIKKKKKKNEKNEKNEKTEKTEINEINEINEINEKNEKNEKNEKIEKRNTHQTNEINANLPISNKTNDEENKDISNEKKFKKNLKESQQITSVYFDNKDATCFSKRILRYENAQLIRFRWYNDNEYDHNKIIFIERKIHHEEWTGENSTKERFELEQKYVLKYMNGELNIRDYFIKKLNKKKKELYKIGNKKSCITEQVNCVDEKKIKNLEKKTKKNIKLANEIQQIILNNNLEPIIRTSYLRSAFQQSTDNTIRISIDTNISMLNEYIKKREYWCRLSEEILGKNEVIRLNYGIIEVKLKVNKIPEWITNILNSNESINLYKYSKYQTAMALLHSEKIKYIPIWIYENIHERFESKSNFSDLTIKDSHGHISDFEKIGNNMNQYSNKYLYPTNGYTTDLNMSAYNTLDKMDELEKTFYWINNKYNKHFKENEKINLLKIDPKVNFAAERTFLHYAIVSKQYNSKAENWGIQHKASTIRQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEF7</accession>
    <name>V7PEF7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_04947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEF7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="801"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="827"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB57112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="103301" checksum="AA4158A8C977CD8F" modified="2014-02-19" version="1">MFPRVKYRFEKTESSNSEENIDNHQNNKNGKLLEHEHISMKKIRNVLYDEAMNYSEINTYYKSSNIHNYNNMNAYINYIKKSNYTRSYEQENIYNEALLLYNNRNTYIRNAYRNDEYLDIKRNLKKGEYFGDNDEDYLFDETNDTNKISKQKDADADADGYDVGNTDNNEFGKNNLTKKRIEYEHLYKERKKERAMKFAEKYGDLFYDEKDKIINDNGDLNDKQNNHMGYITSGNGHIQKNNKNQASSTNILDDLLELHSMENTGSFCDEKETNFLETLVKLRYTPEQISKLSDLFENPRTLKNVNINLLKWLDMQLNKGYWLERISLFLLGLAISIGVGNIETIWILMTTWHGVVFLLPYVLCYMFVCHPILMFELYSGQLVRNSSPFIFYKLLKPCASIGFVALFLCLLSSYIHTYRTAAEYLIYLINSFKHDLPWKLTQNEIDFCTQIKNDAITCLKHRPLCLFSKSISSCVPNNIGKAFLIYHDKFFPSNDKYTFLLNLNKKKNSINIFSNSDSYIDKDSFVFLLFCNLLATFFQLLGMTNFAFSVALVLLLLGFLSITKFIALFNLSSVMEAYFYILKMWNFSYLYTYSSIWSQCMMYALYEMSIGMGIYSSLATKTRIGSNLAFDGQAIVVGNSVISILVFFSAVAIIGFTSKIMKSTFVEILEFSRKDCSFILFPVGFSNLQRTEKTLCMLYYGSYTILSCATLAIQREVFIISMKDFKFSKNINKRTLVLIFTLLFFVFSFFISTKNSKDIIWFLSFTISDNGRILVALLICIVLGWVYNIEYQYKRLTSRSVLAFNITYWILNIFFSILFNYLPYHVYILYIVRLVIFMFSTCISITMLKSQINEMKGQQKQMHSNLTYKVSIEKGKKLIIKNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PEF8</accession>
    <name>V7PEF8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PEF8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="133" mass="15970" checksum="A310037E8D3DBFA3" modified="2014-02-19" version="1">MNNVLFLYLSLFSYFCVASLCYQMIYVNFFDENKKNDLENISCYWQYFCHGNFHFCQYGCSLKKKLKKGYNLLNINSYTFSANSLQENCFINIECDDYDIYFDSEDPSYIFFFSNTYFRITSDSTLYVNLYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGD7</accession>
    <name>V7PGD7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_04639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGD7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="94"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB57832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="276" mass="32828" checksum="345CBDCC31D8A8C6" modified="2014-02-19" version="1">MNNYFSFIIVTSLSVFLYICYLYCLQNDHLNNYSKFLRIFLALISAPLFVLYYWAFVKCSACNPGYVDDIWEINAEENNIQIENRKIRNYTPNKYTICDKCNYLVRPERAHHCRTCQRCVLKMDHHCPWIGTCVGEKNLKFFFLFLIYGLFISLFVNITIMPQFVKSIYETDEAKESYKMHHAAIFISVSATTTLALALIFMVFRYIYFISHNITTIESSYADKNPYDIGTYSNWKEVFGNFQWKWFFPFNPDNLYITSNLYKIHLQEKLCFSCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGD8</accession>
    <name>V7PGD8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor eIF-2B subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGD8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB58591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="33087" checksum="724E197979276F71" modified="2014-02-19" version="1">MKLNEAKSQLNNYIKNENVKNQIILTPHSKRMTIYTIVTACDIYHHFAVKKYTHNENNFDDLKSISSKCASEFPKTLQNSLDMIAKNSCTLFGSGKTKILTFSSSDCVKALLLNVAKNKKIKICVYFTCPENCNNNNYLEKDKFFDNKFINDLKNENIDVIKINIQEIQNIFEIIDFVIIGTELVIDNGGIITKKGIKLISELCLLNKKELFVLCEAYKFLKIKTIQNYDEHFYYYCTKNIANKNNFLYEFVPHNFITLFYTDIGIFPPSTISFELNKLYINDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGE2</accession>
    <name>V7PGE2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGE2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="191" mass="22673" checksum="6F6527AEFB864962" modified="2014-02-19" version="1">MNKCNSIFSLKNEFLDKHFFCLFWKNNFHTSPICKNRKSSTFLINFNKKNIAVCEQNEKNNDNAENTALSEEIKRETNSIQHVFKWGIGNKFRSDPENRFHPVHLLRPKEVTIKKSYFDSTNENIKYEDLNEQWEVFWFENNKLNAKPFPIKKYGIEAAKKEAFKFYETLQSQNRINPKPKHESGVEGSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGE9</accession>
    <name>V7PGE9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Erythrocyte binding antigen 175 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_04322</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the apicomplexan parasites AMA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1740.170:FF:000001">
        <property type="entry name" value="Erythrocyte binding antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.170">
        <property type="entry name" value="Erythrocyte binding antigen 175 region VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003298">
        <property type="entry name" value="Apmem_Ag1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021620">
        <property type="entry name" value="EBA-175_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043057">
        <property type="entry name" value="EBA-175_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02430">
        <property type="entry name" value="AMA-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11556">
        <property type="entry name" value="EBA-175_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764013" description="Erythrocyte binding antigen 175 C-terminal domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="domain" description="Erythrocyte binding antigen 175 C-terminal" evidence="11">
        <location>
            <begin position="1251"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1114"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB57423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1368" mass="159437" checksum="7C70BB463DE26BC5" modified="2014-02-19" version="1">MKIYHNIFGFCIFISLWTPSIRAIDNPQEDFMDRFDILNNHVNIKWTNSGSLGQGNLKFDIYDEDNISSKLNSLENARLCPNNENGNIYRGSCPDYGKTFSMDLDKDEYSEDFLNEISLGLLNKKLLIDVEIPVNMSGLAMYQGLFANCPYDKNHVNDIKNEKEYDMCFDKFYSNKQNISTRIKKYPLISKYTYFGSHGLGGRLGSNTEYPLHIYNPIENYRTQKMRYPKLVETLEDCSIYSHCIGPCFDRDFDNKCFRDLPVAFNHKTKECIIIGTHEEKKTTNCNSDNSRNNGRCFSSIKKEKGKDWTYASSFLRPDYETKCPPRYPLNNSEFGYFNYNTGNCESPTKLYDNSVISFNECIEKLFNFNYANEDPGEKRNNYLWGVWVLGNKQNKLNSMNDLGVCALLREKPTCVLKKQNYYSFTNLTANYFDNNQNIEYPDIENVKIWKNRNSELSDNLKYNDKKFKNSDISKGMAINMNDINEIKENSKLQTNIHNETKKTKYGLYNYPITPISYLQIHHKMELKNYNMDSENSFTSFHNTNAPTHYEGNSKFSTGANNKRENTYGTQDINLNRNNNYNQPKNKPNPQAEYMDRFDIEKNHIYIDWKQDGKYGSDKLKYNIISHETADTIQSLLITNKDDICPNHYSPGRAQGSCPNYGKSVVVKAPGSINGDEYLNSNFLNEIHTGYLNRYMKSNVELPYEKSGLAMHHGDLSVCPKSWDEENMYKKNKDYNYDMCKSTVMKTAIPLKMFDYKTKKLLYFGLYGLGGRLGSNISRVKNIFKSQPNNITLPMFNPSSIKNLLDCSLYSYCLGPCLENAYNNKCFRNLPAYFNHETNECVILGTHEQERKNDCRTRRSDTDKPNCQNVRKNISTKNWTYVTSFIRPDYEEKCPPRYPLKFKSFGKYDEETGKCKSLINKKNIINIPLFSSCLEYMFIMYPSVLQRTEKKNYWGVWVASESVNSSNLYNAKGECYYINEKPNCVIDKVNHFSFTSLTTNDIDFNQNINLVKLDELVINNDQSSSHNRAKYNTPIENSESTIVRKHNSAPEHFRSLKINSYTPNRRGENFAKESDSTRNTDESKMDEVIRKREEAAKNAEIIRKFEEAQKAAWAKKAEEERKKAEAVKKAEEERKKAEAAKKAEEERKKAEAKAEEERKRIEAVKKAEEERKRIEAAKKAEEERKIIEEAKKAEEERIKAEAVKKEEEVIKKNSNLAETKISNNNYETRNIDDNSFKKLDEAEYTSRNIDNTRDKIISMSKENMCINDISSKYCDYMKDKISSGNCSNNERKQLCCSISDYCLNYFDYNSNKYYDCTKKEFSDPLYKCFSNEEYSITFFYRSGLFCWGGNNNVNPDCHMFKNYRKKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGF1</accession>
    <name>V7PGF1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_04648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGF1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000440">
        <property type="entry name" value="CMGC/DYRK/PRP4 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="240"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB57847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="574" mass="66924" checksum="0F15E6BC8C7749A8" modified="2014-02-19" version="1">MMSENNDNNKETDVSTNKQHTVSNNNDKENEISINSNAKINEKCENTFTTCKKNDMSESLSEMPSMLDDIEQNEAACIFAPNNEVIEETCSSLSSDHEIIDDKVPNEKNETMKESNDLYTDLKKKINEEKIKIRNFIIKQKELHERNKMNGDDPAYINKRKENSEMNNNESIGFQEQEDDIDNEDVDMFSSEQTNKKRAIENIRITDYYSANNANLSDNWNDSEGYYKAIVGEVIDNRYSVVCELVGKGVFSNVLKCYDMTNKMHVAIKVIRDNHMMHKAAEKEIFILKKLNDYDKDNKKHIIRLLRSVKYKNHLCLIFEWMWGNLRIALKKYGNGHGLNATAVHCYTKQLFIALRHMRKCRIMHADLKPDNILINEKFNALKVCDLGSASDISENEITSYLVSRFYRAPEIILGFRYDSQIDVWSAAATVFELATGKILFPGKSNNHMIKLMMEYKGKFSHKMIKGGQFYSQHFNENLDFIYVDRDHYTKKEVVRIISDLRPTKNITCDLLEHQYWLKGNSPKMQFLKKKIKQLGDLLEKCLMLDPSKRYTPDQALQHPYLRESIHYSKMQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGF5</accession>
    <name>V7PGF5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGF5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000040">
        <property type="entry name" value="GTPase-activating protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="101"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="372" mass="44520" checksum="4F9A4252485D4A39" modified="2014-02-19" version="1">MRINFFKEKNKIKLNKNHNFDSDNTFSNENPESNKCLASISDDEYDHYGFEKSREAISVEDIDKEALEKRKRKIEKKWQQYFTVKRDIKKNYYLKKLIRKGIPDKFRMNIWPYLLGSVVLYTKYPTIYERCLNSEIEPKVLSQIELDMLRTFPHNKNYQLNAQGLTKLRNVLRAFAIYKPKINYCQSMNFIAAITLLFLKEELAFWSIVQLIDSDYSHKKINISDYYNHEMRGLRRDIIVIEELIKIKFPNIYMHMKEFDVDVSWICSEWLLCLFCTAFPITTTLRIWDCLFYEGDKILFRIVLALFKMNQEKLIKSNSLESILYLFKESTKNMVESDKLMHTAFKEIGSLKKKKIKKLRMKADDIIKRTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGG4</accession>
    <name>V7PGG4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGG4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="60" mass="7275" checksum="6504BE986AE50722" modified="2014-02-19" version="1">MQYTNYEFTMDEPIQDTLIRDAKSIYKNILQSCFHQYDNDNIVKKWDLWGSFIVYVTLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGG5</accession>
    <name>V7PGG5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L13, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_04165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGG5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB58080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="202" mass="23772" checksum="E6409896D0DC14A6" modified="2014-02-19" version="1">MYKKEYVIDCKGHMLGRLASIIAKELLNGQRIVAVRCEDIDISGSLYRNKLKYQEFLRLRTNTNPKKGPLHLREPSKILWRCVRGMLPHKTPKGKIALSKLKVLVGMPYPYDKKKKYVLPGALRAFRLQKHRRFCRLGTLSSRVGWNYDELVKKKEQVRKELSKIYYKKKVNTLNEKKKIKEEALGLIKPEERKILENFGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGG7</accession>
    <name>V7PGG7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGG7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="33530" checksum="A3853D82F9F5AB0E" modified="2014-02-19" version="1">MKDNYDRQIILEEKIKNKENKIKLYDLQIKKFKLNIGDMHERIKKARYETLEREKSLSFLDQFKDNPSELVQLDMFDRLETIFSSRKFIKKKKEKLNAKINIIKEKIKELEEKNNLILINKETQYKKLQEESERIINNEKEIKEELKENINEHNKDALLLYKIISCIDNFLSRFSSFLPELRHYNIKKDDVNSEKKNKAQDIIEDPYFIDTVDFNNLEDEILKKLDLIYKYIKDTIYIINKAKKEIPLKDGNQIKAVEYNLNESIEFFTYNGNGKGKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGI9</accession>
    <name>V7PGI9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Anamorsin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_03805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anamorsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGI9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin C-terminal" evidence="10">
        <location>
            <begin position="168"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB58651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="238" mass="27490" checksum="A5A1FB35EB24826C" modified="2014-02-19" version="1">MINFSNTLVILNNDVPCELLKKKYSELLIPTISILDFKKKKIYKKYNNIFLYSYQNYSFLLDLNDNILLKIQKYLNKNGILDINLYLNDKNNNSNNRGTNKKDHSKIEDISQILKKLRKECLYNGYINISTEQTTSENGIVINIKAENPDFNKSDDDNNLVSSDEEIYEKCEDKKKVVNRVCDNCTCGKKEKAMNLEKIKINDNEVEYSTENVVSSCGNCYLGDAFRCGSCPYKGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PGJ3</accession>
    <name>V7PGJ3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PGJ3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48031:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48031">
        <property type="entry name" value="SRA STEM-LOOP-INTERACTING RNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1040" mass="124130" checksum="90F5037B1E7FA1FD" modified="2014-02-19" version="1">MFEAKSYKWYFENGCEIVPLKKPYDKKNDYSLTLLDIQADFSDFLAEEKNIISIDKLGKEEESGFNLQKNQFIQKETKKKSTIEREKYVYEIDYLWAYMEWHYSFQDEIKVQKNLIKDINKLKKVPKLFVSAHIIDGVINEMSKNENICILKYTTYPNFYKKYNNELDILSKKSNNSIYNVCNYIYEVCDIADKSLTFANSPIINTTVKNVLSITKSGKKREDFIEENEKEDIEEDEIWQIYLSKTLKNINDQWLLICINDELKNIINNSGDIYFKMFNKYIKEYNEFITNHNYSLTSNDKGTSGNDNNSTHMSNSNMFKNEDKNNFFELNSHNNNLNLEKIKKYKINLIFSENKDINHIIYKLCTNLGRFNDVVLCTTNKTYNILMNDVDGTLAICLKSFFSKYYINSDIEKKLYSQEMENGMCNLKKTNSIPFNDDLIKTLSIMGLCKEKIILSEKATIFNNIELFFSYYLLVHSEALYGQSEGCKLIKEGLNYSEKETNEIDDGVIYISKKGIFENLQFSNEEICSYLMHMQKYSKNNMIYIKNKGFRYIKSEIIYEFLIKMMELISINDNLYEYQYIENPNKISSKNNNVSIFDKYRYDLYKGLKKRYGITFLNIMKLIYDNIDDFDFLSTNKIGLEKYIILQLCWKCFDIENINFEYFNIYYNYYFFYEYLNKGSSELTFENMLENYFVFLNNDKYIDETIIFLNLFKLHNIMSLNIIRGSGKVTIHSEKLFTFDMDMFTYIKYVDENFQNFNSNLMDKIIQSFIKNYQFFLDYGYDRECVKKNVSNVFQDENYNTNLKEMNKKDNFVDDGTENTIYKNRVLFRNNIILNVNNINHICNDNFMFEYFVVVKYFYSENNFSLLEKKIKKIVNMLKGTYNGNQGGENVNDGHENYELSEKFENFNSSHLDNLADYDIQKKYNSNYSKNMKYNYCLNYKIFKYQTNSFPHIRLNNNYNDLLISVYTPLSLHCSIFRENVIYNKKKNSFQLIPPFLLKNNLRSCLTVLFALKNSYYSQEFYPFLNPLLNNKVIYIFLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIH2</accession>
    <name>V7PIH2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIH2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000010">
        <property type="entry name" value="Probable inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB59234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="394" mass="46497" checksum="3E806801447E7BC0" modified="2014-02-19" version="1">MLMPFKIANFVKIGIQTATLSNIQKRKMSSAIINPDNRNLLNMDVKNEYNVKTNNELKVNLNFHNNNIISNMFSNLSLYESMNNFFQINNKHYMLKYNNQLNQTDFNISYFQNINDKYVQISPWHDIDLMNSDGTYNMIVEIPKYNYIKLEIKLTEKYNVIKQDTKKGKLRYYHNSIYWNYGALPRTYEYPKHIYRCKGSDDQQIFFTGDDDPLDVIDIGSNSLKMGQIAPVKILGAFTLIDEGQLDWKIIAINKYDENYSNINNLEDIEKYYPHTLNLMIEWFRSYKMADSKKLNIISKKLYNKKDSENLIKKVHDYYLEFLKDIKQFSLSSSCESTNINNSSNATNSSECFQTSFSYQNPDNPVYNNLVQDVSIDYYKSDDTYRPNMEIWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIH4</accession>
    <name>V7PIH4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U2 snRNP-associated SURP motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_02883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIH4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="5">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="6">
        <location>
            <begin position="222"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB59366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="58387" checksum="454EDB0675C3FC7F" modified="2014-02-19" version="1">MFPFDCYAQVTEEYLCQRFGKFGKVSSVKIMYPRKEEDKKKGRISGFVCFENKEDAENAKDALDGVEMFGKPVIIGWSKAIPKILSLNKNEYKNSHFDKNKSSFNTSNKRIQIILPEDKKVKRIIDLLAKYVTEEGYAFEEIIKKNEKDNPMFNFIFNTSDLHYYYKWRVFSFAQGDSYRNWRVDSFQMYENSYVYIPPVPKNKKDNVPRINKKMKNKKCDMDEKKKSKLISIINNLSKKRVSICRAMIFCTRHSDFSFDIVKIISSYLTDLKYDLLKKINLVYLLSDILYNCSNQFFSSWPYRKHMEEALPRIFYYFRKHIKKCDSKIKAKLFSDSIMSIFNMWDTWAIYTIVFMNGLKCLLSSKKLNYIKNKMHDSENEHDILNGTKIEFFDDLKIYPLNLRRNAYIYFQKDENQINRLCEQRGLYYDENFNKKKKIKYLLIYDDFYGFNTNNVGSGKNYLNEVALSDGNKNSSSKISETSDTALHDNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIH7</accession>
    <name>V7PIH7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIH7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000010">
        <property type="entry name" value="Probable inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB59239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="367" mass="43423" checksum="E674D5958E6673F0" modified="2014-02-19" version="1">MSSAIINPDNRNLLNMDVKNEYNVKTNNELKVNLNFHNNNIISNMFSNLSLYESMNNFFQINNKHYMLKYNNQLNQTDFNISYFQNINDKYVQISPWHDIDLMNSDGTYNMIVEIPKYNYIKLEIKLTEKYNVIKQDTKKGKLRYYHNSIYWNYGALPRTYEYPKHIYRCKGSDDQQIFFTGDDDPLDVIDIGSNSLKMGQIAPVKILGAFTLIDEGQLDWKIIAINKYDENYSNINNLEDIEKYYPHTLNLMIEWFRSYKMADSKKLNIISKKLYNKKDSENLIKKVHDYYLEFLKDIKQFSLSSSCESTNINNSSNATNSSECFQTSFSYQNPDNPVYNNLVQDVSIDYYKSDDTYRPNMEIWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PII0</accession>
    <name>V7PII0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635790">
        <property type="protein sequence ID" value="ETB58088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PII0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="263" mass="30353" checksum="D48670DBC9B69FB2" modified="2014-02-19" version="1">MENDDNIFNFILKDNKVIIGGKLNINLNITNDTLLSYTLHAKSVKYFYYPMGANPTCFLYNGGVEDASSNQLPLQHKSEIAIPLNQNENGLTTEIFLKIKYRLLKPFTYIYTIPLHLGYIILNSHKREIQSLYNDCKRFNILYFSVLFDELYISNKIKKINNDKRYELIFSCKCFVDDNVDNFFNSSPVHKNIILENLNNDPNLVDDLNNSSPVNKNMILENLDNDPNLVDLNNSSPVNKNMILENLDNDPNLVDDLNNSNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PII3</accession>
    <name>V7PII3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PII3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="805"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB58840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1253" mass="149071" checksum="AE023958D349687D" modified="2014-02-19" version="1">MTIGLFRFQMDNINEEIDENMSPLEKAMLYGNSNLKCRKILFIKDIIKLLNNIDYTDFQRDIYPLIVKLSDESSEIKYEICNKIGDLCAYILQNNNDGCSDVISLLFPIVEKFIINYENNKNILRYILKSLLILSTHVNIKTRKKQIFPFLIYLICNDAYKQIGFILLIKMCYIFDRDNIVIYKVLIPFIEKHCISNNIECKILISSYFFNICKMLDESNFIKNQIFIFNKLCNDEYDTIKIINIFNCTHLSSIYSKNLFFNFFLPIFNNFLKNNNLYVFYYSLINLLLFLCIFEDINIIHPFYIRKIIFFFNNLFSSHLFTLNYLNEMAKKKTNYIFLDNTDGVYDDSNSAKIWNKDEKRDDTPSYPLNETDMVTDFQNSKSEKNNEHTIQNTISNELKYYDNYLNEDMCKEKQNNLVEIIEKDPTRQICNDEQNLTTGCNIISPINGKGLWVEDNKNPHKNSPMQELPQNKSDKNINNESDERDKLGIGNISCEIESTEESKNCNFSSESEILNKRKMEKVLFSSEISELECSSVQSLSNEIIYDENVCIFINNKLINDLIIKNHHFCSNISQFFKTHGNDYYKNGNCDKYFGRKIINLMEKNSDDLILENKINGETIESEEFEKDEENYFINLNEKDIKYIDNIFNHDDNIDILQIKGCYYSELEIIKNDIIYGKMLLRQKRNMYKINNNNKCDSSDNITYDIDYEDIYAIEGVDTDSLKKLFLFDTPNNVIVSYNINAVYIITLHIPGLILILKEYFFRFFSHVFFFICTYPYYFVRKTIASLFYDILSNLMESPFFKINTDKLYEDRINMKKQKKNLKKNKKIEETAKKKLKEECSDDIKKKENNYDGEDSTEQSNLYTYKENNIKHQDINHIYKKEPPEIVQTFNNDYATYNNMKRIQNNSFLTSDKSCENTEDFINSCIMEKHEDVLEKEENKLCDDTLDMIYSNNSNTNGSHYSLDQDDTKNITTDTIDQIKEDKNDIQLKRVKKNAQGYRKKWSYDKMIKKVQNKINNNLYANDFFINEENENFFFYINFLGKYEMIYIKYIQKFKKYYSDNSPLHFFHFFIYYFLNDSNVLVKKAILKNYDKIIEFFPNNIQKIFIKYLSDVVNFKTLNYSLRKKVSKIVFKILSKINDAKIVRNCLFPIFMRLCKDEAAIIRTYTSNYFYLFIEKGCPRIYNFFKNGGEILPLEDYKKDIILTNLENDELRSFHFISGEEIYILKTVITTFYKSDRFYDRQVFIKICDGIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PII6</accession>
    <name>V7PII6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PII6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="27845" checksum="DAB3F81CE545A0FD" modified="2014-02-19" version="1">MEKNYKIVKYGNNFNVSKELRSYMLKIMKEYKDYFEKEFIKNCNLENNINLMENLEIKEDNDYNEDVFIKNQKSFHIYDFFNLSLLFPIKILNQNGKSIIQLISEDNTPNDLNMIQTILKNIEQTEMDKLRFFHIENIIYELIDELIRQIAVDCPKRGFSLIVINNEIKKNIDYYKRLIEIIEHNNNMNTEKFNEMQRKYSIMIEQLSVEENNLKEKLADIQNELELLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIJ0</accession>
    <name>V7PIJ0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIJ0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="25488" checksum="A00ED7256D63A7D2" modified="2014-02-19" version="1">MEKNYKIVKYGNNFNVSKELRSYMLKIMKEYKDYFEKEFIKNCNLENNINLMENLEIKEDNDYNEDVFIKNQKSFHIYDFFNLSLLFPIKILNQNGKSIIQLISEDNTPNDLNMIQTILKNIEQTEMDKLRFFHIENIIYELIDELIRQIAVDCPKRGFSLIVINNEIKKNIDYYKRLIEIIEHNNNMNTEKFNEMQRKYSIMVTTRTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIJ1</accession>
    <name>V7PIJ1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIJ1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB58850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="138" mass="16035" checksum="F1F45CEAB69B1FF5" modified="2014-02-19" version="1">MNHQAALTRKQCDFTKLIMAGYDLELNNGSTQDFDVMFHGPNGTAYEGGIWKVHVTLPDDYPFASPSIGFINKLLHPNVDEASGSVCLDVINQTWTPLYSIHFRNFINMCTYPIYPYFRLYIFLDLIYQYHIIYLFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIJ9</accession>
    <name>V7PIJ9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Folate transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_03767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIJ9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17484">
        <property type="entry name" value="MFS_FBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF0">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB58587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="47241" checksum="5BB9FC71186BC865" modified="2014-02-19" version="1">MLMSIIKIPWAIKLLWGIISDTYPIFGYRRKYYLIFGSGLCILSLLILGLISHTNIFLTIFLLVIYFFGSSLCNVIGEAQVIESSRKGSANTSVKNISIFFAFRKIGFAIMHYLSGYLLSILNNQHIFLISSILPLSIFISAFFVVEKRDYKKCKIKKQIKSIYEIIKTSYIQKLILFIFIMMSTPSSGSILFFFMANELQFKPKLLGKISMFQSLASLLAILLYMLILSKINIKKLLLYSTIIMAPFSLLPLLAIHKINIFIPNTLFIITDTMLVEFIGELQSIPILVQCSRIIPKGFESTIYSFLLSVNNFAVMVSSFISSIITYQLGITSTNFDNLSKMIIICCLTNIIPIIFLYNTTKFDNDSKPCKNNDNNTLNSSDNESAFFDSTSYEIKNCEEIKYFITENGHDIPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIK3</accession>
    <name>V7PIK3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin NUP100/NSP100</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="930"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1218"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="983"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1653" mass="185519" checksum="F0CB20A139840512" modified="2014-02-19" version="1">MFGGMSSGMNQNKPGGLLGNLQSPNQGTTGTTTSSSIFGNSASGMNQNRGTTLFSGMSNTGTSTTNTTNNLFGGTSTMGQNKLGGVFGNLQSTDQNAQNSGNTTNSLFGGMSGNQLKPMSTGSNLFGGMSTNTTTNTGTSNLFGNNNATSGMNQNKPSSNIFGSLSSTTQPTGTTTSGSSTTGNIFGSTQTANQGMGSNVFGSSMGMNQNKFGNIFGGTSTNQSNTMSSTFGNTGLGTSGISSTSALGSGTNTSTGLGGGLGISSSGIGGTGTNTGMNISNLTNTTGGTTTGISTSSGSSNLFGGLSSTSNTNTMSLGDNKNLFGSKPGFSLGTGTNISGQSSTNLGLGTNLGSGLLNPSMNTTTSSVLGTNLGSSSTGSTNLLTGLTGGIGSSSTLGLGTTTSPTIGLSSSSSNILGSTNNVLNNTSLSSNLLSSGSGMNQTGISFLGDKNLIGGNQGNMQNNLLTVDGKDKSNDLLTNKLNINKESSENLIKTTKFDDDLIISKKKEDIFNKAYDDENDISNDEMNLIKNQDGTFYNYINLIINDNINDIQKTTFSLLNDHDSLMWDNFKSSIFKNFVDYLVNFKQKKNQKIIKSNVLDLDQHEFQILIWLYNINSYKIDFIPFKSFYYLLLSDTNLNYSKMFISNSDKSILPRNFVEINDHYYMNYKSYFFKSQINKHHDNYSTLNRDGIGNSSNGGVSGNSISIGMNNSVLDIDSIYKQILKDILNSLLNMNLSITKENIKKKEKEEYYENGDINNKNNGNCGSSYIYENLLLNYLFGTLQHLHDKFYKLEISNYLSKDLNQIDEYFVDTKSNEIFSYCYDNFYKNEMDKENCTIHFFFYLVNIMFRCGNYIGLIQIIKNDEFIKNLNIDSYLNDFIILLIRILLLIYNQSNEISIFENMKIDIDCSDIFKKKIHMSNLINFFHSILYLCSNNIYAYDLLCILFSDIFYKKGNMYTNREKKIEMKNIFYYVQKKKRNSNYVDNNSDRNSSNEDNYDSGGDNNNIGRGSNSTNINKGGKGKGNERKGFFLDVFTNMLHKSKKSKDDEDEPFGTMEINEEIEKLNRESMNTSNTEMLGITNKYSYNFEYCNIETSIWIELSLFLSKNFDLYGSKFQENFDILDTNLSYYNYDDDNNAFLNDTKHRRDMINSKIEELFISISNCIINENREYFSVCSKLRVDDVINNFIIVDGKISEKVKSNVFKVLRTNFLLYIKLFYYLLLVGNIYVTVGFLSCISNNIQRILLVLTIFLHKNNVFENSKLNNIKIKTLGFLKLKTDNSTILYNSKDINDNVSTGSDNMNLILLSMNNIDIPFDYFLLRNNNINILLKASYLLNLKTNISIKLLKSIVQENQGILLNESIIGHINNDGNIFYGKLHDFLFLFKNKVKSRRNIKCFFLMYYVLYKKKFYNSNILRKIRKDIDNEYHYKCRNFKFVQNKNINTLNKISLDNSIINVHSSILYKISQFYSILAYFANQRKNYIVSFICYYILNDEQSAINSLLRIYNDELIYYYFNNEKEYGYIRKCAFRFYHLAKNMWPSNVKLESIEQKSYLILSILFMKKKMFEEAFAIFSLALIPDNMLEKLSTADYYNIDLSSNFLVTLRELCKKNYKISELVDQSMVRSVIKFLLPIKDKLDAQVVESINYLGSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIK9</accession>
    <name>V7PIK9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-like protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_03773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIK9"/>
    <dbReference type="MEROPS" id="S54.021"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="75"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB58597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="254" mass="29091" checksum="1B80A2C29C15E825" modified="2014-02-19" version="1">MIAIIMTAIIMINSICYTNIKTDYFVCPCRIIVWISFFQIIIYILSCLLSENLTVPNVDVLMFLGATYGPSVKQGELWRLLFPIFLHANWWHLIINIICILNLGLVIETKYKKKRFLLIYFLSGFIGNTLTIICNPCQLAVGASTSGFGLIGCSIMEIFLAWKNLSKKAQNYYMFNICIFLVFFLFVSFSPTVDFFGHIGGFVCGAFLACHYNKFLGYDIFQECLHYGFASICALIIFYLPLRLFILNMPCEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIL1</accession>
    <name>V7PIL1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2235" mass="264159" checksum="447615170D4033F4" modified="2014-02-19" version="1">MCLECNPLEFCDDNERVWSFKNMCMKKKGKEYVKLCEETKKKEIYNLNIYCPKKGVCSNMEKNKSCVDGNKLIQCKICEENYRYDLISPAINSCVYCNWASYLAIFYFMIIMILINILRVIYINNLEITRIINAFIKYIHYISLLRYINSNYDNEIINVVYLFTVGIPLNEILDCIFTGGTNNERIVQKINFLLCCPLLFSALGILGTLIVFLIRKNKKDSKNVEKCLMINPYDFIDKKLAKKTSTDIKFSNPFNMNIDNCDMDNINVEMTIDEDEKYDIDNLKNCFILFYILYNNFLYFEIIRLCIFFGFCNYDENRKEYFLIIDDSLKCSEIGYYGKVIIIIIFCTCIKFMNYFFVLFKNNKKKWILKDILLLYQKIEKFNKVDNILLLFFLVLFYKRFLNNSNPSLIYNYKNGLYNGNIHIFQYILIIIPFFIYILIMYLYVYEFNDSVCGKCENSYDSEKLNSEKLNVKDKRKQYKNIKCISNNLYSCNNLTIDNVEIDKNEKGSGKNNYTFNGIISEDKKEPKNNSKAINNNWNKTDKLSSNNDIGMVKIKIFISKLIQKVKNPTMNKIESNDKKIDQFLFSFSFFLYGTILLSYYLFLSYVHINKFGGILTIIVIACNVAIYFFLFSKFIIYFKDDIKKKCERTLNIIIKKIKRLGLFGIGNSRKNRDVDIFKDVKKNDNSLKEKKTKMEEDLVLNKEDKNKNKNKKSINNIIKKNLGYNYNKPNFKGINSFVENNYKNIKHKAKRYKLLNISKTWIYFLYNIIDLSNEPEICLAMLICLTLQNEFLNMNLDRCLEVLENNNFCKITNLKIVLKNFIKYRNKFLKILSENSNMSIRFNNCEVDTKSDEIKSNNNVNNNNNANNNIICEDYESLIVFAWGMSILCYCNLKDINYNLSNILLYVSNVLNTCRYFKNIIDICFGDYYNYDFSHNNKDSIENNVKCNLYSYNNLDFNNDYNYINHNSNLNIMDKANNNVQIYSKDFQEPFYNDMGKSVYSENEETKFNKNNRMLTSVGKCDVIDYTTKGEYNNKGSFSGLLIKGNMKNMEHSFVRNQNKQVNKQNEVTKKKWLVDIYNMYISEVCRIYIHCLLVDIGELYFNIHYNYTCEKYICNNLLNLWGYNISNNLYMKRYFENIEKFNKNNMMDILLYNKDINLNIDGNFVLNISDYINKNVINIDFYNIFKKIGKSHRIQIKKLIKEGDYLNYNSLVEFSKIYTDYEEIEQIQNIEVDNKIKNDFFKVFSNAFPLFIEKDNYKYLDMNEINKIEEKKKFIILYKTMGEKYIEEYILKNYEGSKINYFQMDNYGAVISICGSFLKNLLKIEENQFGKMENNTDEGILKNETVKREKYIVNNNTTENDMLNKIHLNMINKNEYNYTNCEFLENKKIGIFSHNNYECKEGVTGDLKGIDLRNGNSLIGIFPSVVLPNAFTIELWLYFNSKNKNNNNNLKSFIVCDKNGNSIFVIDRKNDKIESIGIFSNEINFLSENYKRRYYICNENKKCGKKEKKNVVVNKKVYNGIYIQSEKLKKWEKINKILKINKWNLLNVTKCATGLVYYINGKYLSNISHEILNLEKSFEICIFGNSCFGNNNIGLFSSFKIFEFLNNEEIKKRYKLIKSVKNKEMIGDNINMEKNNNVIEGIDIKMNYMKGNEEEYFIYFIQSPKNKYKVVPTINNPKYGIKIYQLKFVIIKNECNKMEENIDKENRHMKSHFKIINIDNMNEYGFDFYYKKIGKKLDGVPKIYGINIFSDYLIFGCDLSQFYTIVLYPSLCIYNELVKPCGYTISGWFFFPVEKNISFLSLISGTNDVHICVFSDDMILGSIENYVRSNKNNERYTVYHSSGLSIKDIKKGWYYLSVVGTLNGQFYFINGCFKGYHKFCSFDNIKYIGNSSLFINPFPYICFIKVIGRVLSVNEILHEYSISSGYNNFTYLYYYYYLFLLFSNNEENDDGSFVSKNSLIDRSHTRADVISSDDTNSLYCYNKEKYIYFYITKNYNVYIYPLEESKNYYFTLSLVSMINKKLYIFNSINDQINNLNIYFINYIVLPEQWTIFALINIPHINESNYHCLVGGINGRSHIVIDNDNMVLGVLENAEVFKNEEAFKNKNIYEQNEKYNNDIKGGDDDNFTQIRYKEAYQKFYSCGYKFENPLNKDILLITRCINNQQTFFINNTNVGTCRSCRSAITCFGNCLSTNNEYSAPFGNYKFIKIVFGYINDDKIKEFYTNYSLYRNKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIL8</accession>
    <name>V7PIL8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIL8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="37194" checksum="C8EB3375A9F483CF" modified="2014-02-19" version="1">MKEILANPPQEKCSLHDIFFQKNEKKMFIKHNLISYILNFMDFQTLMRFKECSKIDNEVVSLYLRKKLYSLSFKDNEIKTNIHYWKNVINFFFFKAGTLRPIDRTNYSLVFNELEKNKSFCIITKNSMTSNIFISSDYFTENLIKTCNHNNPLPHTCNIKNEIQGSTYFKSENITLTQFISEYFKRLQINDDELMWNLFHFRRRPEFLSLLFLEYIKCMLSVLNKYNGSCIFKKTEYLVNSGHHISHRLWIQMFYEYGYEPTKEKNKVTQKATFQESRFRNKQPSPPLANNNNNRTLYLTIADHYKWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIL9</accession>
    <name>V7PIL9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIL9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030124">
        <property type="term" value="C:AP-4 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017109">
        <property type="entry name" value="AP4_complex_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037097">
        <property type="entry name" value="AP4_complex_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="51"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="807"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="888"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="972"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1033"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="815"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="888"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="902"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="976"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1066"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB59284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1170" mass="135145" checksum="C8F6A62884DF3932" modified="2014-02-19" version="1">MISLGGSSLSKEFFDLAKSIGDSRSKQEEDRIICNEIVLLKSRFANPNATVKQIKEYLIRAIYIEMLGHDASFAYIHAVKLAHEKNILCKRTGYLSCNLFLNKDHELMLLLINTIQKDLKSDNHLEVWAALNCVCKLLNSEMIPAIFPIIKNLLNHKNELIRKKVCMLLHKIYLIDPTLIKEIDVYLKKLLCDVDPSVMGASLNLIFAIANNDMIYCMELVPYLVSILKQICENKLPKDYDYHRIPAPWIQIKILSIFRILGFSNKKISEQMYEVLQKTMQRADYGINVGYAIIYECVKTITTIYPSHRLLELASLSISRFISSENHNLKYVGVTGLALIVKINPIYATKHQLAVVDCLEDKDETLKMKTLDLLYEMTNPLNVQVIVDKLIFHVENSQDMHFKHDLACKIIQLIERYPPNDIWFLNKINTLFLSVGELIDEAYSYSLIKLLKDCPIDVDSDISDDFPPIDENSQSNNINKEEKYLNGEDLLKGSEDAGNDLNGESGENNKNNVGEKLKNEEDNETDLPNNTNSSKNNKNEKKKSNDDTLNLRKYAVNTYIKMLEENENIPFVLIQIICFVLGEYSYLCDLENYTAEDILDLLCECMEKNLTNPDRVKSCIITAIFKLCCYNNITDHVVTNKIIEKYKSSQITDIQQKCYEYDLILKNSELIKNVFSKNNKTQNIVIDENLSFLNPFIDKHLESGGKSYVAKDLRQCENNFETTKTPSLALNFTPYELPINNNINSDIYNASSPNLLYQKNRELSSFSNSQINEDCSSQREKGKKMFKLNVVGPKKWKKETSKMEDIEINENKNNNAKKKKKKKKKGKKNVNIYPGTNNGIINYLGEDRNKLSIEKTNKKQYNNLDNVNQSYKRGESYFKNSYYEGKTNKEVNEEKEIYNEHSEDDEDEDEEDEDEEDEDEEDSDDDSYTSENNEHEKRMDFMQDYTDTNYENLYGNSIEGIKNNKYGNLSFNKKGTNKDEQSTFRNKGMEDRTNELSEKEKMAAALFNGLVSNNTSVFDSKNIYSQNFTNKKSLSISNSNKNDLKHNKDSSNKINVKNNSFEESKNTVNPPNQYDNRMTNKHEEHDSSASIITRRNLNNSNKLGDPSKKIYSYDMIDLNEMPESRDITLENNENKEKDKGMWNDIENQKKAVFLNKSKLSIFQTIKKFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIM1</accession>
    <name>V7PIM1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635773">
        <property type="protein sequence ID" value="ETB58612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIM1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="654"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB58612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="755" mass="88991" checksum="FB0F51C351190DF0" modified="2014-02-19" version="1">MKNELNGGREKPNCLDVMSCEVSSECEDLKTYHNEIKYLKKEQLKAYICKLKKEIKNYKNKELNYIIEIKYLRRKIIRLQNVIENDKVLKRDQFNYFLNHEKRGYSLKNYNNNMDIGFTENVIFTDNNFINKNRHHSFNRSATSLIYDNNDRNHKCGINDRCGSNGNSNMRRQSCGNKSFFKSDSIRSINQDIHKGKILIDKKDEDYEIYNGISKEIVGLKNEWKKIEKQNGNKKIIHTIKPIEKVYSCGEVFDNNKIINSKNYDDNMDKYRNNRREHSLYNLNLYKNPKNIGSEKGEKKEIFVSNRSYSSTSKFELKRHLISNNKNMSRMSSHINSIIEKDINKYNKSKENILYQKNEKTQSKNNFLNALTYENKHRSCSSIHSNLIMKKYKNIEKTNTIKINKNTFDTYNDAYHKKILSKKYTSPYAYQNSGKASSNKYSNKKSDIIRRNIKNVETKFGKYIPNEDQILENENLDKLDKKNEVRKNEVRKNEARKNVIYYPCIENGNQLVENDYMGIKRGTYNNLVKKYDSDNIKLEEDCDSSSSINKIKKYFQNEKKKKKKKKKKSEKKAGKNEEKKAGKKEEKKAGKNEEKKAEQNEEKANNNWGTTLKWKGRKASEKSETCFNDITKKETKSIEDDNNKNNRYLLNLKKVIQSDLKENFKEELEKLKKRNNMLISKPNVYCDIPFDSTSGGSDKDNYSKSSDDKKKNIGTKNRDKINISYLKGPTILNTSFNDIEKRISNLQNYLKKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIM2</accession>
    <name>V7PIM2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIM2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="568"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB59416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="855" mass="102009" checksum="D11DBFC9F93B8785" modified="2014-02-19" version="1">MDQHQNYSNEKNINNEKIRKDPNFSEKLLKNLRDNIFENNNCINMNSSENSSFLQTNLEKNTNFYINESEKFRDNQINKNCTNSIKREHNVDGENVPISSCNIDINDNSSDNNFKVLEKLHNGDIEHTNFVNDQLDNSKQNVCGNIKRCENGNAENVEKIEKSGSTENVEKNGSMENVEKNGSMENKCTFKMEEYISNKSVEGNTFKENKDQICEDSKRCEENENPNLETKRKNEHSFSKEIKALNPPKNVYEYNHNVIYHELYIELLEVNKNLQNEIKNLEKIIEMQKELIKSKEGDIFENNNMIEKRKMSSKSFVNNNYFLNFFNKKNKTSKKKDDEQGKADNEEDNEIFEKDEGLAESNYNYNQQRKGSMTRFQNMPFSFFSDKSSKQKKQKSTESINTINLSIQEKDNEKQKNKRNIGTPKWTKQFDYKWIKSINNSNSFQECEFIYNDDMKKNDEIDNDENSDINNKYMKLALRENEYVEFYDNDDSCTFDNSNNKMNKKKSYTFFKDKSNSKEIEKYRDCDYKDINTIKEITLIKYWYNKIIPLINDEKKKYTLIELIMMNYMPQVIREYFWKENINNKLNITDYFVKVLIKNANFIQIYIYINNKQYYNIFSRYFKNLINLEKSSINIVPSLLTENCFVDENELINTVKESELYKKMITEKIFIEDDEEISIDIKENGKVTCSEKSIKMNTELNSISSNLNKDEKCDKENNKKDKIEMKNFEHLNINILQRYSIHKFFYQILIDLDRTMYIIKKNQEYYHRTNIDKDNFLFDLNIHDIKKNLNKLLQMYVIFKPELGYIQGMSYIALVFVLHCKLEKAFIHFANFMVRAYFENSLKMIEKRKEVVNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIN4</accession>
    <name>V7PIN4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein BOP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIN4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="410"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB59426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="736" mass="87088" checksum="F15895023CEAF2BE" modified="2014-02-19" version="1">MPFPFLYICHFPFYIYVGYDIDGKKIEKTNENMIDDFIESKKDVDAWRKIKDKKNNRVVTLTDADLEIIRKIRENSVAKYIDESSYIYENDREEYKLPTNFNVNKNNKVSKGEKKKILKLMKYLIDKEKHPEKYKNNQNSNQEELTLYDMWNNKIYDEYSNMNEINLPNILPGHKYSYNPPPELIYTNSDEKNILKNNKDAFIPKNWEKITNIEYYKKTYYDLYQRCLDIYLCSRSVKSVLDIKKEDLLPKLPTTQSLKPYPQYPFIKYNINDKIKNEDNGHNYICLNENDHIFYVIKNNKLYIFDILTSYNIDVIDLESYFNSALSPNKNDKQNNKNLMIKINKTYSLLAISWGNVIILLQYESYIPPIKSNTIDVEQIYYDIKKRKSDSVNDTSKNDEHNESSKDGAEFETDQDDDNQIFEDDWDDEDVSDDENGENDESDENGENGENDESDNNLKKKKNSDLSKNMIYCKTKELINSFNQNFKNTDEYISSSDLDIKWIKIPSNNKKLKYCVAIKHEGLIKNFSWNKNGNYLSVTCLRKLGQYHHCYLHHIKSMRTIKLINKYKQKRGDIIQTMFFPRTPYFIAAFENSIIIYNLKPSSKKEKIFKKLRGVKNATSIDIHTNESYILVSDEKGNVFIYDLDLASSPYKMFHAQNCPLKKAEFHKEYNLFYSLGSNGVINLFYSKFFNDYITDPILVPIKEIKNEAKIIDLTWSEKKPWLFAHTESNFSVLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKN8</accession>
    <name>V7PKN8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_02994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF3">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="89"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="773"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1454"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1650"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB59540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2049" mass="241398" checksum="6D6A475FA4186DDC" modified="2014-02-19" version="1">MNQYDQWNRRIRTIWYCSSLYVEYKNALRKSKKMPVEKKNEYWEKKHEEFATKMLNNIYELRGWWVKVGQFLSTQENIMPVAYIEKFTKLQDMMPTSPFEKIEIILKRELGSMYEFFEYIDKTPLASASIGQVHKARLKKGIVIDNMNKSYKNDYNVIIKIQHEGIDKFLSSDISTLKKVSWAFGLIDKNFNFGDYIEEWQNSASRELNYNYEVYHQLLAYNTYKKSSIDLKIPKIYCAYTTSKVLVMEYIKGFKITDTKYIKKYNINTYDLIYRIIDYFAYQIHSDGFFHGDPHPGNILVMLKRDCNKNKISRYNKYLKKKKKKKKYYGINELNNQNRILNYSENEFRSISNYDNKINKYVKGHSLGNESCASMEEFISSRYNITKLKSGINKSQNFYSKTCSSSGIRKKRKKDITDKVLREDYKYLINNDDKTNENGMSKNKGGQESTITSNKDASKLDNSGSYIKSDSKILKITKNRNNGILNFLWKNQSEANKNGGGQNEGDKNESDKNEGDQNEGGQNEGDPNEGGQNEGGQNEGDQNEGDPNEGCVTSGELDDGMIKEKDNNLSKKSDKNDLKKKEKRKKRSYECVPVIIDWGLIKQLDNVMKLAFCKLVYNINCMNFLNIIEAFEDMGFCFNDDFTYDPEIYIENLKKFFLKKFEESEIKSKENESSINNNGKENNISFLKNIDKNDVIEKSPISDVPKDIIFFLRVASLLHGLCTQMNVKINYLSIFSKRAKEALENIYKPIDTSIYITPISKKPKTFLEKRIHNFIKKLYEKEKILGCQICIIHKRKVVVDTCVGMMGIIDKRPITRHSLFNGYSLNKLILNIALIHLIYNKTNDKINSEKERYKNSEKEKIKKFKQKLNSPISNYLDGFICNNKKYITIKDLLTLKCFIRKPFHENITLNKFINYDSMINMIENAKNYNVKNRSKKYGEYMYLIDTYIISELIYNISGLKYHEYIYRNIIKPLNLEEDIFIPLPSYFLKSFNDKNKHENKKIVSGIGSSNNFVNNSSHLIKDNEFDRHNDENDSISNYKTSYIESYYNSKDNENKNNNNFSNFRKKKNEYKNKKPFLNYKDNSNILENEDASNNNKFKNKKMNKIYNLSNNVFENKFINISNYNYKINKNNILKNKKFIKNLNRSLSVDVYYLKKKNIDIKKKVKCESIEKTKLLSLNHSQYSYSDINDNTNVKSDKFDKPDKFDKSDKFDKPDKFDKSDKFDKSDKFDKLQSFKDSEKKKNNKENFYDAKDDITEDNINNRCNDKIKNNIKQKDIFSLKHTFLNHVDNLKEKTKKINDSIKNIYENNDNIFLKNLFTSQKKAEKGEKYNNSHFDNSTHFDSSANFDNNNDLEKDYDIRNIEYKRLYEKKKLKKNKKSDIFFENILKNGKINNVDKILNINKLKSPLKILEKNKKKINIRNNSNRRSLSYNNIDHENNLFKNLESINDTNHDCNQNMPKFTNENDENDENDENKKGKLDYNKNSQNELIPSIFINNIILESKVDKGGNIEPVSIKDVNIESATVKDGNREPVAIQNGGERKSGEYLNINKNAKKLYKQIASENSSDESVNSTLKENYNNYQKKKNMKYKKLYKYITELKEYIRDKEEKLENIKKNEFEYSNSFIFENDNSDNLFKINQENYNKNGGSNYQANSNNDIKKKEEEYEIMKKELSKEKNLLKKLIDYKYLIIKKQIENINKKKTKKMIYNNSHTDEYDMFSDTEYSSTDGYTNYFLNKDDLKIKDRNINEKIKKLETYLIMKKTYKKNNDGHIPEIHHTINKNTQVYWKLVCSKRNETIAEKLSENGNLKNNFDNILNTNLKKSKKKINTDNGSDDIQKNNEINNLKKENDNNVTNLNKTNKQDEKIEPKFKSYLNHFNSKQCNKYISFFQLAKNKPYVLDPLIYDSKKILDKFIPINGRFTAKALTKILAYTNENIFFPSKIMNKMRKEYTIEKSIESFILTGGMSRKWGLGFQIFECEYDGEINEEFLIKKKKRYTNRQVDKCTKRIVGYGQSDCSGCFTLSFPEINLSITLLLSDLYKGAEVRKYKHCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKP2</accession>
    <name>V7PKP2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKP2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="294" mass="35676" checksum="38590D75F49A8DBF" modified="2014-02-19" version="1">MGNILGSIIGNKETNPNKTNISIFEKRYGYNLNDLHSYIYQINLPLKPPYINYVFQEKKEKNESMEIFNDKNNDNKTVNDLNNTVDIYNKYDKDNINNSNNIYKNKLIINNVEDNKKHDDKYVHLGYNKNYIFDKNKNNIYTEDNISKYISEQKMDEKNNFDIKKTYLNLCLNYYNNIDTCVTKKYQKNVQNKKYKFTRLHTCKPHYILFSRCVKFRDKKIMKEIKKMELDYYNALSPQNKYQHMHAYIFFILSFNVFSLFKYEQKKYIPLYVYLFFRSSYLSEFSTNLSYHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKP6</accession>
    <name>V7PKP6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKP6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="228" mass="27678" checksum="AB33A429B9AE4075" modified="2014-02-19" version="1">MEIFNDKNNDNKTVNDLNNTVDIYNKYDKDNINNSNNIYKNKLIINNVEDNKKHDDKYVHLGYNKNYIFDKNKNNIYTEDNISKYISEQKMDEKNNFDIKKTYLNLCLNYYNNIDTCVTKKYQKNVQNKKYKFTRLHTCKPHYILFSRCVKFRDKKIMKEIKKMELDYYNALSPQNKSSYLSEFSTNLSYHEYRINQAYEGVEKIRLNKELNELRERYNNILKSNGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKP9</accession>
    <name>V7PKP9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein regulatory complex protein 1/2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKP9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="63229" checksum="47794E3C77E683D0" modified="2014-02-19" version="1">MDTLINISKETRIEIRRNRIQKKSHVSEKTSKETTYPEAYQYQLDTQNNEKNENNFEKNFKQIFEYKQNESNINDDNNHINIINNANEEKDILLQNVITEVNNEKKSFIDNIQKYVIDVKDNNDILFQKYNNEMLLEHEEIYKSKFQNNFADVKNLALKEKETYEKKIEKYFSLLKYKDENIKKVCKNNSQNILSLISVIQNQRDGYKMYLENLLNKTRDELNYKRKNMLKENKQILDDFIRIQSMNSTIFIDELNDVKSFNQKIKDIHEENNLKLKTKIQLEENLNMDMQSILDINNIIMDKEKKIYNIKVLQQKNSHNLKKINFYKLEINKLRESLISIKTHYYNYKIKSKKMVNELINQYERIKFQFIELQKRQKSYEKFFQKKYATAWNLQKNEASTYIEKLIDANKIIYEQIFFKEFYHINYKHFLEETSIFPSATTKVNDGNEQTSITMQSVTTEQIENVKRLILDECGFLVDENLEYQDKLNKLLNYIGVHTEEDIELLTKLFYTGKEIPKCQYYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKQ3</accession>
    <name>V7PKQ3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein L7Ae/L30e/S12e/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKQ3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22998" checksum="49D8D5CF62AA68B6" modified="2014-02-19" version="1">MEERTKTRIKRVMESPYNVNITPLDQDKSSKILKLLFEVISKDKSLASLFLKHDEIKDGLDDDKIEAIILIKTVQYEKFYKHIPIIASLKNVHFVLIEKEYIESSGFNCLNNPSLIGIKKTENKNNELSNLHEQINNLTKLINSYYTPINIPYLFNNTKYINTKFKVEKVKGKYYGKNLSRKEKKKIRKSIKKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKQ8</accession>
    <name>V7PKQ8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit 6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKQ8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB60126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="12306" checksum="1D2B8A838C76094C" modified="2014-02-19" version="1">MAESNSLNHKFMKNYDEITSQNPHSSDPRFLQMNQFNHCAYRYTMFCRCAKELGDDDPRCKFQYYRAQIACTVEQLEEWDDQRQKGTCVMDTLPDRLTAHLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKR4</accession>
    <name>V7PKR4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKR4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21455">
        <property type="entry name" value="DLC-like_DYNLT1_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10688" checksum="D22BF950523772C1" modified="2014-02-19" version="1">MNETDKFKDEFDIELMEEIGKETISQFLEKMYYNEEKTKIWVSQILDTTLKELSKLNKPFKYVATCTLMEKNGSPLTASNICLWDENSDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKR8</accession>
    <name>V7PKR8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKR8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="675" mass="80141" checksum="DCADE5DCC5932B58" modified="2014-02-19" version="1">MQRILKENYFFKESNNLKDILVITKYLNKAKNIINNIPYFLYTIMEEFETSGSTFQENMYLFVLLALNMWLKKITQECERFISDPKTKGKKCKKEKENEKYKIYKEYLYDIIQRGAEQTEMFNDDKVLFYYPSNMKFNVNTSFLTYHFLYINKNLFNFIKKKIKIKKGQKEIQYNTITKIIEKINYKEKDDSAYMKNDIYNYNLYNEYVDLYSLINLSFKIDNENIYPNIFLIKNYMHEEAKNIIDIIYKLQNKYLNLIIYQDVSIIIQLILYILDNLKMLSKKECQQNFDDYSSESKKYISNIKCNYLNMYSKILFPIRLTFLNILKFVHNILKTHKWNYICTFWSKIKENKFDSHTDTNDTTKHNVIDENKKGLGIKNEENCSENGSENCSKNSKFNYLPLLLDECNEDNCYNFNKKKKKKNTYNNFEANCELAEQANFELAEQANFELAEQAKFELAEQRMLCFDFYKIVNDNLKNVKIEIENKNNRDIYTGISLKKKNKYKIDKSPKANNYMSSSKQTKTKSTNLKEIQIKTTKLKETKLKETQIKTTKLKEAQIKTTKTINLANNYDKNNTCSILKKIKTQTTLTKKGDNFSVQNKALSKTLKSNNPCLSKIKTDNQKRINQIDVQNKPSINYLNNKIVIEKQINFIPKKIEKVGNGSWVNTKKKVATPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKS6</accession>
    <name>V7PKS6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_03018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKS6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000016">
        <property type="entry name" value="Prefoldin subunit 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB59570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13120" checksum="3E14EF9BF9760C01" modified="2014-02-19" version="1">MENNSITAIPKPNELTESKLTYEQVEKDRVQLVSKIEELYQDVVEHKLVLEALENVPSDRRCYRMVGDILVERTVGEIKPALIDHKNKVEQIIAECQKKLDEKNIEVSQFVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PL05</accession>
    <name>V7PL05_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="6">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PL05"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB59630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="287" mass="34104" checksum="DB95AD83BD9072C7" modified="2014-02-19" version="1">MNNINKQLIKDIYKIGLEHKDFINIDSLEEIYEKKTKEKIKRNEIVYALNILENARACSIKNENNKIITKMRTEEVTKKLKELSDIDFLIFTKVENSQSNGIWTADLRKQTKLLIHQVQKGLKFLCECKLIKQVNNIHVKNRKMYILYDIEASEKVIGGSFYKDGEFNKKVVDYIRENICFYLYNNNNSNVTSVINYIKKLNNSVGYFSDNDIYRVIKTLLFEERIKIYKNNDNEELIYYYNNEKKKILNQFPCFSCDIFNKCNFDTKTTINPKTCLYLNVYLNLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PL11</accession>
    <name>V7PL11_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PL11"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="46"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB60104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="239" mass="28257" checksum="DE7A3323AF5CC2B1" modified="2014-02-19" version="1">MFMEMRKMFMECEKCSWKCMILYLYMLIVYLCMLIVYFFLGQKYLYSIIISNVNSNKLELYKKEFSKFGKIFNIYHDNEKKITYVKYDNKNSCDNAISAMNNSTLDGDTITIVLGKKILDKKNNKNLIQNPNIVNNNKIIPPYKAPMYNTNPFPYYMNNNNFNVPYNNNIPYPNTFQNNFYDKNIQPFNNHKNIYDTTKNNTIIVTNVPTYLNAEDIFSAFQETGKIVDVQILMNEKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>V7PL17</accession>
    <name>V7PL17_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PL17"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="257" mass="30888" checksum="0AFBE30539988BE0" modified="2014-02-19" version="1">MGNILGSIIGNKETNPNKTNISIFEKRYGYNLNDLHSYIYQINLPLKPPYINYVFQEKKEKNESMEIFNDKNNDNKTVNDLNNTVDIYNKYDKDNINNSNNIYKNKLIINNVEDNKKHDDKYVHLGYNKNYIFDKNKNNIYTEDNISKYISEQKMDEKNNFDIKKTYLNLCLNYYNNIDTCVTKKYQKNVQNKKYKFTRLHTCKPHYILFSRCVKFRDKKIMKEIKKMELDYYNALSPQNKSSYLSEFSTNLSYHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PL19</accession>
    <name>V7PL19_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL3c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PL19"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="261" mass="29812" checksum="2CF3410E60D43456" modified="2014-02-19" version="1">MNKRKFQTHMIKKFINARVPFDPQTHLNDIPYKDELDRIQIRGKKIEMRSIFSPNGKLIPATLIKIMPNIIYRFLDFGKVGIAYGKPLNESRWILKPEIGQISKINSNLKNTCSLTLTPPQNFVLGQIIDVSYLYNYKYVNVRGLSKGKGFSGVIKRWGFHRGPMTHGSGHHRKPGSIGASTHIGRVLKGKKMPGKDGNKYRTMINLKLLGLNLERNEILVSGCIPGNRNSDVTVTATRDNKINKYKYILDMLYEQEKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PL44</accession>
    <name>V7PL44_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PL44"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF9">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="824"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="866"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="997"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1034"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1138"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1176"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="700"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1201" mass="139389" checksum="D37D6A41E6993DC4" modified="2014-02-19" version="1">MEDVLENKKYVYKYNKENSYIDMQRNETFRSNKSGNMDETEKDINETNSIYIENLQDENNNINFYDNNNINFYDNNNNNFYDNNNNNFYDNNIEAIKQANGEIQEKYQANNKYNNGNNKTPFAHHTNVSINNKGDHFYEIDNKIALQKQTAQHTNHNVGNHNVGNASDGNCNVLLLNDKSNFERNEKFLNFEKSQKLPNFEKNEKLPNFEIKENEVIYNSNKTNESNNLYSPYYNTEEKEKKQNSIGIYQLNYVNNINNVQFLNSANSTNCTSNNNNANGKNELIYKNSLKKLNENKAHIYNNIMDTQHNNNFYEQNKFNISSMQNNNRKRAWIAQNENGQNYLNHNKETYENNVNNRYNEFGGHIHLYDNTEENSGKNNEENLCNYYKKNDRNEQNEQNERKCGRYYEESKTPLVSHAYIYGENSEQLIKDYNLKIMNKKIRNVSPLHHRAYSNISHKKETKNKIISNIKREHLFSDQTGSNIKYQYNNSPYQKKIKGNKNISLSEIEQKKNINEINKFLNIVNYYENDKNKIKDTEDVSVNLDLVKTFSPNFDKNSTKLSENNYTDKLNKWNDNNKISYNELGKLENYTKCKMMNSYENSELENFEKRTSFSYSGILTSMISSILTQQNDRKIEKNNCLYNNFRGNNNISKNKENYEYNLLYNIKDGEEIKNKYIFSKKVSNKINLKNKKNNNILLLTLTLMIGLSVLCNFDHGAIPVTLEEIQKDFPLSYIEQSLLGSLVYCGLIFGTIIASILFELISAKWLVTISIILLSISLYIFSNANGIIVMYISRFVNGLCQAIPVVYLPVWVDIFSPEEKATQWMSYIQLASIGGTVFGYFLGGILSNNYNQNNILFNNMSFVTTWRSPFLMQAFLLLPIFLIMIFIPSSMINISSKYSDIETEEIENNNKINEKEFGNSNFDNLGMDEYNEMTLNSQSNILTNLNKKKKYILPYQNQQNNINRKNYNRSATYIMEQKTNILRKTFKEVKKLLNNKLYIIITLGMSNLYFVVTGIQFWITEYMSVVLLTEKMKIVTVSTLCFLTSPTSGVWFGGFICDLFGGYKNTNYSKTIKVATAFAISACIFGILSAHLTNFIFFSISLWLCLFTGSALVPVAVGMLLSCVSNHQKSLSSAVSQVIYNVFGWFSAPLLSGIIMDIMHKYTNNNRLALKAGFTMILYSSCIGFFLLLYANFLVIISNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMP6</accession>
    <name>V7PMP6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMP6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="101" mass="11043" checksum="44933031B2776228" modified="2014-02-19" version="1">MMLKKLYNGHFRRVSLSDPNETSASSKKSIDESSNEDKKCENKEYGIVNNIIYGAGLGVGAIGFSLAVLSSTIIASTLVFSLYFCANTCNISDEELFEECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMQ2</accession>
    <name>V7PMQ2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_02557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMQ2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB60235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="163" mass="18711" checksum="BE1B15C7CC36B537" modified="2014-02-19" version="1">MANIAKELLKKQFIELSRDHNVGFSVGLVDDSNFFEWNVCFEGPKNTLYEGGIYNATLSFPSNFPNQPPQMKFNQEMWHPNVYPDGRVCISILHPPGIDIYNEQEKPEERWRPIWSVEGILVSVISMLNEPNLESPANVDAAVQIKNNLNEYKKKVRALARMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMQ6</accession>
    <name>V7PMQ6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_01854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMQ6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF226">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB60891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32825" checksum="76BB10169C48888A" modified="2014-02-19" version="1">MEIKNKSKSFIAVVLTDPSLRRLIFFILTSLIICFLPIYKAIRYIVAKEYGGLSPFDSILYHCITNIIVIIIFYFVLLKKNIGGTTKEVIVNRLKLKGKCIIVTGGYRGIGLAAVHEFLKYECHVVLACRSISHMDFIRASLLKKYPDAKIYCVELDLGSYKSIENCANYILKTFPKIDIIVNNAGFLNRKLEYINGLESTFFINYYGHFYLINLLYNRILTSGTLIVNLSSIAHSLLKESDVDYAFIYENNNDNYSKSNLLYRKEYNFSKLCMLYYSQQLQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMR3</accession>
    <name>V7PMR3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMR3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00139">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="8">
        <location>
            <begin position="810"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1145" mass="133272" checksum="B32FBCAD237E6454" modified="2014-02-19" version="1">MKCGNVNVRNVLEFNLKKNIKEKTKLTDQEIVIIYKRFHSISPNGKLDYKQFEKSLGILGTIKNAYLYKCIFKAFDLNNDGYIDIFEFCVAINIMLKGNKRDKLKLSYRIIQSGSSVKLENLQGEKHSKGDKNLQDEKHLQGEKHSKGDKNLQGEEHSKDDQILKDDKNYLEYINYDDFERIILSIKDIKKQLLGEDDEIVISHVKYTFKSLSILCDDGKDLPENGDEKNGDVKSSNNNTFKKDDIVPSSSEKKLYLNNISTKYNSISQKKQTKDDENELFESGLNNKSGKKILRKIDQIKLDKKINKRCDNIGNDFKKLENQISQNDERTTNIYYDVYKEPEIKNKKNVPNLDLAHIEQEYESKSYMYSTVEKKMNKNGSMNKSGSMNKSGSMNKSGSMNKSGSVDNTEFFDLKLQIFEFEKKEKNKKYIDTWNLYINKYKEYIKRVEEVETGENANGNRDGNASGHGNGCVNGSFSDNLVESNNIEKYYDKCNDIDSIDSDNNSNIYEKDVEGESVESSVSTYTKMSDKINGDIIKLIENQENESNDYISHGSNKKEENSSGTFLFEKYIEYHKFVNETEDIKTLINETYKNSQQLELSSNSQHFLINKNLSKEKLLYHIRIILLNVEDCLKSDKDNENYDKIFLIFFYIFIYNNTHEENTKIESKQVCIRDKHLKKYKSVLLIVSIIRYFLHTITISQKYYCSSYDSIDEYNNNNNNNNNDNDKNNNDNNNDKNNDKNNDKNNDKNNDKNNISKSNHEINIILNQTNDVLGKYAKGKFQNKKIYINKSNYYNSSKKRKLSVSIRHKKKKKTSKLFAVYFGHERWDLVMNMMIGIRICAIKKFNIDNILNYYKHTDVIQLSTSRPNEKVLFKNYSPIIFKNIRKIFGIKSKEYITSVGPEQVISNMVLGNLSTLSELLSEGKSGSLFYFTSNGKYIIKTVNKGIHKLSKKLLPRYYKYIQKNPDSLLTRLYGIHSIKYLNSSSKTIKKIFFIVMNNFFSSAVEIHRRYDIKGSLIGRTVPPEKREDHTIALKDADIDELGDVINIGDENKEKLLNILKSDANFLKENLLLDYSLLFGIHYKELSRDVVCWDKKKTNEIRHVYDEFGLCVAAKPFHQWDHGGMINIDKNRIFFFGIIDIFTKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMR5</accession>
    <name>V7PMR5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMR5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46713">
        <property type="entry name" value="F13M7.16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46713:SF1">
        <property type="entry name" value="F13M7.16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="3">
        <location>
            <begin position="198"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB60072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="285" mass="33924" checksum="9257A7252DDEC96D" modified="2014-02-19" version="1">MRVIKMSEAKTVDEALSWIELIEENPDVVNSKINTDNKGENGNSTESISENVAVDKNIESSKEQKPKLTPEEAQKKAIELQKKIREKKLQKEKEEEIEKEKKRIAMTKEIQKRKEQLEEYERKKYIENLERERNEYKKEKQKQLELLKREYEAKFSMTYNPDSQKKKSIEDLGENQKRDEIAILFNNLKNKHKNNKTELISSLNILRKYFSNIKDNILEKKFQKIKKENKVFIEKIKIYEEMITIFLLVGFEDTGEFYVIKNYPNTYLLSSAIKFIDLVIKNLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMS0</accession>
    <name>V7PMS0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-disulfide reductase</fullName>
            <ecNumber evidence="1">1.8.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_02574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-dithiol + NAD(+) = [protein]-disulfide + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-dithiol + NADP(+) = [protein]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="1"/>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMS0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052259">
        <property type="entry name" value="Nucleoredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871:SF96">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="7">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB60255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="169" mass="19182" checksum="6469713F0E6BE2DD" modified="2014-02-19" version="1">MDLILFPEGSLKNINNTVVNEKHLVGKSVALFFSNGSDPKCRAFLPFLQQYYKTINEAGSSQKIEIIFVSVDTDRASFEDHKKHMPWLYIDVADPLTDILKKHFRVMNAYEVPFYGSGPRSDVPCLVVIGSDGREAQLLHVCSGREEGEKGVLRWDFRNNIYSLNKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMT1</accession>
    <name>V7PMT1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL3c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_02586</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMT1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004764473" description="Large ribosomal subunit protein uL3c" evidence="9">
        <location>
            <begin position="22"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB60270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="315" mass="36388" checksum="24AC14C7B91D299D" modified="2014-02-19" version="1">MHLYFIYKILIFPIICQCVYNYKIKNAFNFFETKFFDNDGSILNNQDIAYPSKWMNKRKFQTHMIKKFINARVPFDPQTHLNDIPYKDELDRIQIRGKKIEMRSIFSPNGKLIPATLIKIMPNIIYRFLDFGKVGIAYGKPLNESRWILKPEIGQISKINSNLKNTCSLTLTPPQNFVLGQIIDVSYLYNYKYVNVRGLSKGKGFSGVIKRWGFHRGPMTHGSGHHRKPGSIGASTHIGRVLKGKKMPGKDGNKYRTMINLKLLGLNLERNEILVSGCIPGNRNSDVTVTATRDNKINKYKYILDMLYEQEKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMV7</accession>
    <name>V7PMV7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMV7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="392" mass="47018" checksum="8F55A7930F853EA5" modified="2014-02-19" version="1">MVKLHDLNTDSYDAQNDCTSLYIGNIFSEIKDEIKNTVIGGNLQNGNYIKDNYKELYSINQNNTDNNENKNGKYNNDLMIDGSNKFVSEYPKINIQEYVNFISNKKNEYKKKKKEYVIKYINYRKLKNFHYKDMEYVFKKYSEFLCLEEKCLLCDNYLSFSYLYLNIYLKSKNNYNENVHKYKKSNNNLLTFCECLESIEYSVQYTSGKKDNCYIDMIHLFKENAYFSLDIHKNIIIKEFIKNVKFTEIYKYNSLSENYYNTFSIKKKNNMDTKYINVCQYIEKPQLTIDHVKALNTHVEIFTPLFKIHNVNTLLTTVEKKLLIDCLKVTKKFFFCDKIDKLTVIIFCYLSNLYNIVMRLNAEYILCCYSQKHLEYFLYVSFLQNMFVQVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMW4</accession>
    <name>V7PMW4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_03101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMW4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="21"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB59673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="656" mass="75351" checksum="0EA8377E179A25CA" modified="2014-02-19" version="1">MSIKELKNKKDLSSSCEQITYKFSNVKYSVDNGNLEILHGINGMILPQKITIIMGPSGSGKTTLLNILSMQILDGVEGNFLINNKPRTKSVKHHMGYVLQDDYFFANLTVYETLEFAARIKLDIKDKKKLEDLINSVLNIMDLTHVKDTIVGNAFIRGISGGQRKRLSIATEILSNPPLLFMDEPTSGLDSAAALSLVECMQKMSRFSNTTILSSLHQPSSQIFEKFDKLIAISSGYIIYQGKTTDLNIYLKKIGFICPHGWNIADYLMEILSNKKNEPILLENYNKYISFNEEEGYYMDLNNINNTIIHNDHDSEIKKKENLENDSNKNNNEQILLSNNISQQDFDNEIKKRDQDSKKLKAIELLISFEMKKASYIMQFLYLLIRGLKKFIVDELTIIKIIDLSITLTIFGFLWSKAFSDPHRVLDSMGAIFFMIAYWTYYPAYLSLYSFPSERVIIAKERNVKTYQVSNYFLSQALAEFIFFFCLIAVWSLFSHIALYGSFKFDVYIGFVFIITLNSLISSSLGYFISTLFDNLSRSVSLLSVSLLTMTLSNGFYVEVAKLKPPVKYLQWFSFQTYTASAMAKIKFSDIFIECLPNNISIECQNINKIPENMVIKQRFADIQLYVSILILFTFYFIIKTCIYISLRWSNALKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PN13</accession>
    <name>V7PN13_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PN13"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="36375" checksum="3FE2F84C27B5313A" modified="2014-02-19" version="1">MLIHLVYVYNLYMCVNIFLFFGKKKRWRKILYEDQEYEDNYVDKDFLSHLLTNFRTEYKYSNIVHRMLCINHQIMIVLFHLLAYYSISNNIISHRFLYTINIIIIILKEVLVYDIHKSLNDSFKNILDTIIIIGIIWILSPVMISLTQTHSDDTVYLVSLCILLPIHFMFHNYGFIYEKNENIDIFDSTSLSCVVVESVILGSRLPSIIQVFSFLFCSSILFFYTPFIVQTIVLKNINYYNYVLFPIIFIILSICIRSISIPLFYVNLFGHAFILFVIPALFVNKHNSKTVLEGPWDISGAPFVQKNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>V7PN15</accession>
    <name>V7PN15_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Coatomer subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">YYC_03132</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PN15"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="11">
        <location>
            <begin position="25"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="12">
        <location>
            <begin position="998"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="13">
        <location>
            <begin position="1117"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETB59723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1274" mass="147610" checksum="9D229F0D01E70016" modified="2014-02-19" version="1">MGTLDLENNCTLYICTDNCEIPSVSEIQKKLESQNVDNKIEGMENLIFNIIQGEPYGNLLMYVIRFIVPHKDHRLKKMCHIFFEVVDKCNNDGNLKEEMILVCNALRNDLISPNEYVRGSTLRLLSKIKYLKILDPLIEAITKNLNHSHSYVRKNAISCIHTIIKNHGIDVIPNAVKEVEKILFLETDISTKRSALSMLIDIDPLTTLKYILSLNDQLYDTADVMLLEVIQLFKKLFIPQIFDDSCLKINGNKDMDDDICSQYDSEKDDDYCEDDENEFDYSQNDLSGYAQNSNDNNILNFKSEEIRFKNKKLNQNDYMPYKNNVINILLNMLNKNVSNSVLYEGSCCLLYISNSTISVKTASECFIKLLISQHDNNIKLIVIDKLYYIMCKWKHILGNYIMDLLRSLNFPSKDIKIKILNLVLHILTKKNVHLVLNVIKKELLKLNEEFIYNSKELISRGNIPNNDPNKIVPITKDEEHGGGSTKVSNLEGFNNAYNNNNNILSNVIDSGNYKKILIKFLQHICNMYTTDCICIVDLLFIYANTQEKNINYESAICIKKLANNSVLQNNILDKIIENMFEIKETTILRIFLWIVGQYMNKNKMILNFINILYEQMSYFLNNNMEESDVVNKLFNEKLKKNKFLNYNEISNNITDNNTTPYFQNIQTKTVILEDGTYATEAFATTPNKNPINLSDSNKNGAKFSANNNSSLNQFLYNLFCENDDLLLSVLCVCITKLYLRLLSNADDVFNFIRLASNIDEQKCGEKCGEKCGEKCGEKCGGKCGEKCGGKCGEKCEEKREENHEQNYDPNLMLKNLNVFRNKSIHILSSIIKYTTQKNIKSVTSVYENDSNVIRITQCLNIFLKLKVGIKNIDNETKKFIETFINGDKYYHDFIKKEEDKYCSLYGSSFKNCRKIETIEDDINNEDDNINNEEDDNISLISDNEMENVDSIINFRILKENKNVLNMLDDEIVTKNENFEQMKLKYSLKNDILYDYNEFKYPIINQDNYSSLFLSKLHKSQPITSIADDIFIEIFPIISSINLILEFYIYNQSGIYLQNIFINLSTHNNLKPIDKIPQFNLAPNEKKKFRTTIKVHTTETGTIFGYVFFEKKNDPQKYYIVLNEININMNDYITASFVSSHLFRIMWSEFEWENKINVNTSISDAFELLKLIIKHTNMTIVERFMPLEYYEHEMKNVGENENITPIDVYISYISTLEDFKSLVNNSAFFSVNLFSRSIFGEDSLANFSVQKNSDGKLTGSIRVRSRTQVCQLCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PN20</accession>
    <name>V7PN20_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_03134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PN20"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483:SF1">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB59728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="34078" checksum="3103E88FF8EBFFB1" modified="2014-02-19" version="1">MDDFINDEINSTDENEPVLLEINDLIKTKWRKNRGSRNIYLNSSVYYYRPQLATHNNVDDLGDYNDSERDDECLLSHEKISNHVNKENYDKKSFIYYFKLIFLRSKLTNYYEQGINKMKNVFTSDKKKENNFFDYSNNFPSEYLNILATRLYYSKITKYLYFFVIILNIYILMTTIFTQMMSKFVVISEIFVIIMLLIEVLLRLTTQGSRYFYHFDGLFDVIITIMCFLLLISSGDLKVFYADNTVKTKKSEIEEIISQSLTILRFSLQFFRTITLFMHCKRTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PN27</accession>
    <name>V7PN27_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PN27"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055164">
        <property type="entry name" value="EDR1/CTR1/ARMC3-like_pept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14381">
        <property type="entry name" value="EDR1_CTR1_ARMC3_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1019"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB60157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1127" mass="129959" checksum="733BE8741A7E819E" modified="2014-02-19" version="1">MHNNSYIEKDNFICLNNNDTNHIIKNGTSHNISNTSTGVSTPISQDNVICNNSNSSNDNSNNISLNGNKKSSSNGNSNNINLNGNKKSSSNGNSNNINLNGNKKSSSNGNSNNINLNGNKKSSSNGNSNNINLNGNKKSSSNGNSNNINLNGNKKSSSNGNSNNINLNGNKKSSSNGNSNNINLNGNKKSSSSNDNSNNISLNGNKKGSSSNNIVDIRNNNSGDNEKLGQLKETNLDNSEPEINPTEKSENAQKNYIEALRKLKSNPEINLKRGDEISKNPCLFIYDNLILKKKNEKVQKLIKKLSINAFNLYFPKSSNIYNQMPMVLSLLNGDVDDVLISLKYLIDYFDKINFLIVNILNKLKKKNKIKNNQVITHLIDFILNKLCEKNINYKYSKTNILDFYDNLMCPGTSFFESGIKSEAINLKDLRLIYFYKHDIKIKKEKSFIKKKSIDINDNEEDILLNNYFIDKDRNIHDFVIKNNENKLNYNKYLKKKKHILTGEIPTPNIYIGINEYFNEKSIFDFDYFDNFDNFDNFDNFDNFDNFSKKNKHPNDINKYIRKYIKNKTKCTQNENNICNCITNIIVSIDNDAKLRNHVSAAKNETKNIKNILIKIRKIENLVDRIIKYDHENQIIYSPDEEEESEKSESEKSEKSEKSEKSEKSEKSEKPNDEHGDIKSKGDIFDFEKSDNFNFSNNKISVHEKFEEKNDEDVMVETDLNGDNTLDKYSKIMEPNQEIHKEKRIRDENDNNEVVKICREICDENLKIENNDTDKEVEDFDKINLKEKENNLINCCIKNESTKQCLNKYNDTLKRTFSEIYSSEEKKQMKKQKTIDSCDNDNDNDNDNGSDESIKTYYWENLDFNCVFLGSIKKGTCRHKSLLFKVLCDAVGIPCRFIRYVKNGQVQYYNLVLIPSIPAQNVVEIIIPIFWDKKIKTKSNISGYNKISISSFLNNIKMKFSNIDNFFLRTWENSTEFINIDDYFTLNKKLGIGGFGEVWSVSLKNEIEDNSSFFFFSIKKTSHLALKIMDINEFNLNESIIMREKAHTNVINFYCVFKGYQLLTNRQHEKERKDSFCFLLELADTSLEKVFSDQKVAYNLNFVRLTLMEIAKYKYFMLINFIISIIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>V7PN28</accession>
    <name>V7PN28_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_03141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PN28"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="241"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB59738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="486" mass="54670" checksum="9308F9685C067E00" modified="2014-02-19" version="1">MLRKFMNRFISNEFVTGSYSSSRGKGKLQNSQNYGYNFNKPLEHKIEEMKENVISKNKDQHEFLQAFEEVLTSLKPVFKKNIIYLGVLENISEPERVIQFRVPWINDNGEHKINRGFRVQYSSVLGPYKGGLRFHPTVNLSVIKFLGFEQIFKNSLTTLPMGGGKGGSDFDPKGKSENEILRFCQSFMDNLFRYIGPNTDIPAGDIGVGSREIGYLFGKYKKLKNKFEGVLTGKNIKWGGSNIRSEATGYGVAYFAENALSDMNESLKNKTCIVSGSGNVAQYLVEKLIEKGAKVLTMSDSSGYILEPNGFTKEQLKYIMEIKNVKRERIKEYLKYSKTAKFFENEKPWNVPCDIVFPCATQNEITENDADLLIKNNCKLLVEGANMPTHIKAMHKLKENKILICPSKAANAGGVAVSGLEMSQNSMRLQWSSEETDQKLQKIMKNIYEQCCDASQKYTGETDLVAGANIAGFLKVADSFIEQGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PN37</accession>
    <name>V7PN37_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PN37"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="255" mass="30152" checksum="61FF2C0A4DA6A45C" modified="2014-02-19" version="1">MNGVGIVKKNKSLNLCLFKSNEKKVGIKISKNMEINICLYKDNKIYFKNELAKYFPYYKDNNISQNIQTEIFYKILNIDKSAIDNEILYNEDCKKNKATSLICEEDITKLARNRNDNFNLKHFLEIKSKKFKNLKKDDCNVNKSNSFCTPYYNYCYSLPNQKINQKINNYSNSLYENPLINSNNTNPSKFPNKFYRNSVPTTDYINKSENDVLPFEFDRFDKFDDKIDKPNTLGEVGMEYEKNKRVKKKKKKIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PN50</accession>
    <name>V7PN50_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PN50"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1274" mass="152204" checksum="AD418E72C577BFF2" modified="2014-02-19" version="1">MDEGINDKSLLELIKYSNNLELKQNEEIETIEICMEKSINLNIFDQFKNIKELYLIKNNITDISPLFKCVNLEILFLQINQIESILGIKSLTKLEKLNLFNNKLTEKFINIEENKNLTYIDLSDNQIENINFLSNTKSLIHINIANNKIKNLDPLKNNENIEYLNVSGNRLQKFEDVQVLWHLTHLKELYLNSIYYRNNVLVNSILYKHYFFNNFPNLQILDHEIIVDKNRKTTLRDMEVLKSIIDFKINLVQEKYYKEKYHILFINNKNICYLNNALKPFHSYCNIEEFLQMNHDKKESMLKIKDEINFLLSAYISRFNYIMRRLKEEKNLQIKYITTSMNSYFNIFFKNITTGQDEYKKIEDFIKLMFKSETLKNYFVDDIKIENIIKVKKLNHGQLDEMIENHLNSLIYQKKLLFLHPYNYCKINNFFEFDEEEKTSEDPEKKKFFEKNYVCSCYNINHILKTLIKLFLEEDCINDLVHLIYYKKKKEDYFIDLKNDINIKKKIMAYKKLDFLVFPIYIVETYLFPSEYKEVSAYSSQEYKANEKKGDKENEDQNINESKFKIYYTLPVHTNLKYIVNVSLVNKNKEKINDKPDINKSNYVAKIEKEKSKKKNFLEYVKMGKMNTNSIGNNKEINDNPSIDCFYFNDKIKDQFLQYALDFDSINFFNITKYFIKLSKVICEIRKNLFLLFSKEGIKSINDISNVADNNENSIHMKEKVELISLDDLEIVKKKKEESLVSDLPLSSINQCNDDNNNETNKKKENVLFLNNLNLSKISLKLLHDKFINLKELYLKNNNIHNLKYFFQYIEEYDMENLEHLDLSFNCIFDITPICNKFKNLIHFDMSYNYLYDYKQIMNFSINHQKIQYLSIKCNSIYFNQNYYDHVHILFPSIKKFNDIELVNKPDLNLRQYCFLETPFENNIHYTDCDNKQTIECRFLSETPIDEEIITMENHQKLYKEINFSNYKFYVKKIDLSSLYIKFELTNLLDFSTFPKLEILNLSNNGIENLSNLKLPPKLKVLNLKNNKIVSIDNFINGELCCIEKIILDNNEIKNIDKINVLKNLKILRCSYNKISNIPILNNLKLIEINIHNNLIKDITNLILIKNKKQLVLLNIYNNKINFSNLDLYLTHIFPSLLILNNNYVERKIDTKKFFKSVYTLDIFFEIYNIYPPYTSLKVLEIKNLKIKNILFNINNDNFKNLEILDISNNYINTIKNLGPLDNLKVLILNNNKHINEDSFICENKKNVLNSFKSLQVYKKYLPEQCMYFLQNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PN51</accession>
    <name>V7PN51_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PN51"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="885"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="963"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1159" mass="137970" checksum="A3EB00F1F99607D2" modified="2014-02-19" version="1">MRKIKKDEIVNVLFTIFLVMIQQLSLLYIILNNTNNYLYLTFLAIDIYLCIYMLWSLYDYNNAGVKISIEWMLYMITLSLKMIIFCFVIIQIEKAKKGDNPFFIYLGNDVLVYNLIYMTPFIYLLFSLRSRNILEYILSNQIIIENILSIDVNIINLLDIIDLTFMYSHLTTIYKILSDTEQYNIQKVYFMLVIVIVSMLLFSFYFPIYTNIEKSYSYDDIDINFVVKNKNIRKKRPDINYQDNFLKTENKFISKKPMLLDAKGGQTNGNETGINNISRYVNHAKTFLNIYDSNKKLLKMTNTIKYKNNDRSKISEKKILFSSSESIYSQKSISTTPSSFYSSNNSNDILSENIFSSTTSSNTSAFSFELSDYSKSNSNDLSITSSSSQTSSSDSSNSPIYAYLPSFFSFASKNRKNNNSYNKKYRDVYTDVYITAKFHFIVGFFLIDVPFLIYRLYFCIKYKVVLTLVIKNVLFLLFRSFKLNEYRLVEKEKHKKNKSNFDFHFYNTENGDNENNDYGQYGDLNSSEISQFVYKNKKSVILDDRNNYKRWKYRNSMRTFKNKAINEMSKMKSKKEYAFLKKKNNKKYLKKKKKKIDILDIFKEEFQENKQKIILEKIAMKNKEQINMNTVYFDKLGNSVSSVVYEKGTNNSISGQINNSDLYNYDNDNYDKIGKNGENKESKNSTKVKFSWREKIKLRKKYKTFINLIYKLKYKREIPIYRFTIKDHITELYNFIFKKINCSNYVFFDDKLVFSYFTNMKFMLIIFLDYLLKIGVTIFFLFILLNNHTFINKQNINYFHDIPIKHNTSHPLLFPQNFDFSKYPNIKLPRNPIHIKYINKDIGNTYSSTITETIPGIIPNGYLNLNIRDNIFTLKWSEIFIYDKIYIYACIAYFFLYFILLIKASTFFDVLFGAIFNTIRNLSYYFSLKQFILFFYTFNGNIYNKNYIYQDRTIRKLNSHLEYYFLLFFNIHYFISFIKHISLYLRILFNFKYVYYYRNLPTGEDKKKNELRYSISAHILFLLCKYSYAPVNLNTLLLGENILSNIILIDNINGFTWVNIIVVILFKGIQILMTKVNYFLIGLFLLHIILYITYAIHAQILRYIILRKIEILFTFKKILISNYEEIPLVPDDNSSYITCRDILKYYSEEGFFSSEGKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PN52</accession>
    <name>V7PN52_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PN52"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="371" mass="43604" checksum="5DD04F156C1D7C42" modified="2014-02-19" version="1">MARMRAVFLFVIITIFIGDIIGEKYKNIKKYKIVRSYICNQYNSDNKFYTENGKKKILNKYRIKYNTKIKRLNVLLNIKEINLIKNVNFLSSINMVTSLSSIFIFMHILNYFKLINNTHRNALLEITDKICSKIFLFNTINDIINTNFQKNIPKYFIIGLFSITQFIFHTLFSNVMACLFYSRDQQNGEKIIEKKNITKCEDNNKENNYLLEKSLSKSNEVSNYIKTKNEDILNKNYHNGSLRNDINNSKQIETSEIERKNNMNNVSLLKHLCTLSHTGLIPMYVFNYMLKKLNYKNDNINIMINFYNLFNSILSKIYVNYFIKNSNIENSGDSSSPDKKINKWCTPLALLNNFQKFAPLFTNSSNDPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PN56</accession>
    <name>V7PN56_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PN56"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="1">
        <location>
            <begin position="493"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="881" mass="104942" checksum="E7FC9B8391AEDDCA" modified="2014-02-19" version="1">MMIRNQCLKKIKTNYALRICLKNIKRYSTTKEKSYIDVQPNDVSFIDIKSIKNKEALKKFYLFYNKKKLSDIYSDYIFLINSQFKNTCDENEVKECTAILKYVANSITLIQFISSKKNYLNSGNSNGFSRYNETQPYYIHNIEKTNKYKEEHMIKIDEKNNLNSNYFFSNNLYKFISKLKKYDIWNYKEKCINKRYMNYHMLFPIVYQDLKKYEQTDNLHNDKNIYLLDCNIFSYYISKKNKNEFIDIIKKVNYNLLTPHDIKNILILLSILHHNNISLSNNKENIIKNNNHNNNGMNVIYKNKEYINKKIFIDIFNNIYNKYIFSKVNKISFYYLYDYILLMCINEVKNGEAYTNIVNVLSNYMNLINKISNKTQGETSETNILGDDNDIISYKDEKHFTNYTDSTSEINENSNDIFTEINLSNEETDCNYPILNKEHYIYIKKNLVKIKKKIINKLLLLYITKYVYNHIDNNLLYSHSDLICENLELIPHYMITNFIFTIGTCKYIDEFCMFMLAKYVQNNINLYNPNEIVIIVNTYADAALEDVNFYETICNYIKSNYKKFSSFDIIKILHAFSKVRIRDEELIKESYKKINNYLDNREKQYNVDKTLIYMTEKESISTSHCKMSQFDNNKINKRKNYILNKYLCAYALIAAGKLDYFNQLDKLFIHLKESIQNEGIDIRGILWMPIAITSFLCIENIFYFIPIYIDLIYNAFKKTQSPKLLSLLIRRHSILLHTIETDIIPKKYFSKDTINKLCFICKSKKDNSKEKVFVPDSSTFHIEVSNALLSLDIPHKKEVNIYPFTIDIFINTPQYFDKNKTKEIYEQTESVHNTFNKINSIKKSNKLVYDDDTNFEHTFENKKAKNKNKNKNEVYTDVPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PN75</accession>
    <name>V7PN75_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sphingomyelin synthase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_01844</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB60879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PN75"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="10">
        <location>
            <begin position="200"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB60879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="359" mass="42221" checksum="631580C2844DB1C7" modified="2014-02-19" version="1">MKDLKVIHSSNTNYIQNEEEKKRIANAYLQVSTHGTALDIENEGERIETQNVLNKKNLYNIFYIRILYAIIFFIVGVFIQCYFIILSDGYYNTGDTPLKDRLHELFEKPSFMSQEFVNTCILSLMGISFLRFGLFSPALLAITMFIRIAIILGSIYSIRSIFIYVTTIPCPVYTCQPLVNNGFLQNLYSIYLIVFAKVYECTDLIISGHTCFTTLFVFTWLYYEKNLFIKLIILLYSIYLYLLIIISRFHYTVDVLLGIFFGSTIFIFYHWLLDVAAKRYVLNKSFCCKRPGFKGSFSDRSVVLNCLIRIIAYMEGLDHRLNIAMYYDKELVSFIIPILYIYIYIYIYYFDLPKNLRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PN86</accession>
    <name>V7PN86_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_03182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PN86"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="236" mass="27286" checksum="1F222E14C5708D4C" modified="2014-02-19" version="1">MEMKKLELDILKDFVKKDTEHSDIYKKFHCISSDYISFDKKEGKDGQTNEGKSGNKSEQETKGSSFIDKITSFIGIFNYNKINNIYSEKIHRMHNNIQEENNVPNEHTNDKTEFIENHEITKNEKPNSYMELSTGGSSSKGLFSSDKERANENYKVGNLGSFYMIFGASNIDYPWACTCDPLQLIEYKEKKRSYVLCSNQVDMSIQNSDLYCNPKNSSHYFYLSYILILIIIIISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PP71</accession>
    <name>V7PP71_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PP71"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="47"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="240" mass="27736" checksum="C0174A57AEDE8D07" modified="2014-02-19" version="1">MSIKSKLDMSLDELIEKENAKANKKISIDKKAINKTIEKNGGQKYLYSIIISNVNSNKLELYKKEFSKFGKIFNIYHDNEKKITYVKYDNKNSCDNAISAMNNSTLDGDTITIVLGKKILDKKNNKNLIQNPNIVNNNKIIPPYKAPMYNTNPFPYYMNNNNFNVPYNNNIPYPNTFQNNFYDKNIQPFNNHKNIYDTTKNNTIIVTNVPTYLNAEDIFSAFQETGKIVDVQILMNEKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PP73</accession>
    <name>V7PP73_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PP73"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="265" mass="32466" checksum="8E05FE61894DD853" modified="2014-02-19" version="1">MEIFNDKNNDNKTVNDLNNTVDIYNKYDKDNINNSNNIYKNKLIINNVEDNKKHDDKYVHLGYNKNYIFDKNKNNIYTEDNISKYISEQKMDEKNNFDIKKTYLNLCLNYYNNIDTCVTKKYQKNVQNKKYKFTRLHTCKPHYILFSRCVKFRDKKIMKEIKKMELDYYNALSPQNKYQHMHAYIFFILSFNVFSLFKYEQKKYIPLYVYLFFRSSYLSEFSTNLSYHEYRINQAYEGVEKIRLNKELNELRERYNNILKSNGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>V7PP92</accession>
    <name>V7PP92_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_01174</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PP92"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB61239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="18693" checksum="5381AFA3E0FCA2A4" modified="2014-02-19" version="1">MKNGITFMAMTDRELGFLIPYSFLEEVSKIFFKHFNYTSDFITLSLDEEFKTVLKENMRKFNDYEANEVHNLKSQISNIQNIIIENIEKILERREKIDILVNRSEKLRHENFNFRREAMRLNFYMWMENNRFLIYVISSMAIFILVIWSFYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PP94</accession>
    <name>V7PP94_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PP94"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21455">
        <property type="entry name" value="DLC-like_DYNLT1_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11462" checksum="040C69D1FD03762E" modified="2014-02-19" version="1">MNETDKFKDEFDIELMEEIGKETISQFLEKMYYNEEKTKIWVSQILDTTLKELSKLNKPFKYVATCTLMEKNGSPLTASNICLWDENSDALKTNSCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PP95</accession>
    <name>V7PP95_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PP95"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="906" mass="106825" checksum="BA76BB050412063D" modified="2014-02-19" version="1">MSYENYFKDITNYEKKSFTSSFDLSSATENSSFVIEKKLALFYTLKSIFLLIFKGIKINKCYLNILSDCSVLCFLDSNGILVNTNHSVKEICIYNQLNNKKNVNDNNNNMKKIHNYYNNILTIIDIFMDNKSMYAYQRIQNIKILHSLFLISYFTQLLKYIKNLDDFQNNILNYMNHQDYNHLYTCMCDIGNISYPYNKFSFRMLFFCIENKSDYELYKKKNLELKRNKKGKIDGEIPYYVDKNEKGNELGINIYDNLITRDNFVFIFILYEKKKNKYHMFFKGQLDALVSKCMFYYDGKMIKKLKRRKKKVLKILNMQWISSGLESICFAYRPLSTDEINYLKTNFTKNIYILTINKRKVYNIKNFYNEPNFPCKENERFLSHLISTSIFIGNSAVKILTSNDIQARINDFYDAGIRFVYFSNKDQINTRNISNTLGMETNWNTSISLSLNDKSSFRNRDGKVVIPSGINNIKTHIQEIDDIPLRVSSYSGCNQFNTAEMIKILLENNEIITCVGNSLNCCNFELYKLCNYSISVLLPYNNICTDCYGKKERSNPFGKPAVNKNPLIAYSSFVNSFPCNLTIEKNILDLSENIMELVYKLLKSSRIYKKNLSISMFYFYFYYCYLSFLLFVINVFFLPPLISLVDYLLLILFIIPILSISLLNNNNNSTIMNDIPDKVISIDFLVKKLFFFLIRWVSFLTFSIIVSVYYIHILNDTFVDKYVIKGTLNSDKLSSLGQNFVKDVIYYCSKNINIKSLYKCHIFMHRFSENQNMNRDNIGVSMIKQYQIFFFFSFSLFFFVSSLSYSDKYEALFKLSCIQNSKSYFSCLIVYLILSFLYVAFRIYMLPIYYIKQYPDTTLILLLAIFSIILLLINETLKRIEEKIKINRQKYLKVLFGTRLGMWSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQZ6</accession>
    <name>V7PQZ6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fam-a protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635754">
        <property type="protein sequence ID" value="ETB60768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQZ6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006486">
        <property type="entry name" value="PYST_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01599">
        <property type="entry name" value="PYST-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26957" checksum="1BA93EC2BA3BD10D" modified="2014-02-19" version="1">MSILINDSSEEIYEKNKHLLYTEPEETINADEFMKEAVSQLVYHATSKDDYELCGVSPDCYIALYKKKHEGHTTVKKIYYSVYDFDQYNEIINELWDPDHASFLNIGSVKIVRVYNPNLVMIQQRYQNLYESDQKYFYALATKVEISKNKTIVAISSANINDHNRKNKKYFENTIVESANLFQAEVDSEEDIRKGKLKKTFVNIAGYLIENKGDCVNITYIESVSDIHILLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTA6</accession>
    <name>V7PTA6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTA6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 4 C-terminal" evidence="2">
        <location>
            <begin position="570"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="813" mass="95457" checksum="84747CECFDC57A6C" modified="2014-02-19" version="1">MIENEIVELIKKKDIENVKNKINIYLSLFTTQNKKSFVDKTDNTNSTLKSGEVNGEVNGEVNGEVSGGERNDSKEIPFKESENSDNSHCSSNESDRSGGKEDEICGNKNDVDEYLIYYDEYLFVCIVIYKLVEIEIDKIIDLLKKKIVSSEDNIYIECIKNCYNCLYKYNLYFENLVKDNLVYIIYNRKIELIYNKIISVIFQTFCSQAKLCINSFDELKDYDKNIEILSVLCYNFVNIKIYLHDLYINKFQKLNNMFDIKNYINTNIYSNINGIYKNIPYINIIQDSICFYIDHEILFSRHCINKAFILTDDIMLSLINDENNKTVEPFNQNISTYNDEIYSINSAGNNNEYTSTFLEDSFFIFQKSVCRSINMNDINIICVLINNIMIIISTTLKEYLKDNIKTSRNIYSSFIHDINNLKKFSFKKLLKSIDNNNYTENSKNNKTVQIAQNFVTSLSYISSDNNNDDDKKNNFSNISNISNFSNYNVADASNNSHTTHHGLNNTSDKLLTGHSKNNTKTVNNKIKIDDIYNYLSQDNYNNLYNPLNNNQDNNIENQIINSKFSYPHCVNNIEACHQYIQKYKIFIHDYFSERFLQNDISQKKKTQNYLLMFNNALTNYDNILNDYEKLNIENCKNLLNILKIHFVSQLVVIENINFDISSEQYSYYQLNDPYIHNLTVKIKLILHHISLYFNQNIFHIIVNMLAEKICKYIERIIMTKKFSLYGCVQIDNDIRNLMLFFTSVTSINIKKEFLKLLEICELLNINDLQDFKDFYDENKNNLTTNEIENIISLRNDIPDDFLKSIKLYMNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTB0</accession>
    <name>V7PTB0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1495"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1891"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2000"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1502"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1900"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2000"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2025"/>
            <end position="2037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2051" mass="240365" checksum="39791B7CF99F906D" modified="2014-02-19" version="1">MCIMLVVTESTLEKQRNRNYPRNSQIPSKNNSTQIKVIANRITPYCKDILKTERETIKTRKFIKDYKTKYKYIFSKNNTDNSEREKKAKLYSVEKKANLFQLKKLSKSKKKNQVSANRVNYNCIVNNSHIKNSDQEKNSYQLHLKDKKHKHLNKKSKKNLQSDIRDILLDNPNHIYGNDFPNLNTISNNNNNNLKNKVKTNNDILYNKNVTSRKSNASYKLIDNSSFNTPCIDNNINDDDDVFKSYINDSISKKSLYSPHCKHKITTNSLIDSIVSLSNDLNTSTEQKDNEYDKNLLSYVNKILHDNNFYHGISLGVNKTELKQLESEIHKKCNDMISKFYFKTIFKNRNCTQKKKNSILKDSYNSYNSKYYDSQSSSKLVINENSNNVPKHLCHEKNRIKSPLSSNIHDNFYYSDNYFSEKPRKSEKKNNNNRTKQNNKACEVSLKNNNLITGKKNNITLAKNISKENINYKLTLDNDKLSVNYLKESHLHNNLKSFNQNFKPKKKRSIETQLTLGNTVTSSVCNNVDIKPFKYDDNNNNKDIVHDSYNSVNKLNYDGIVNTNNQINHVNKQLSTLNNFEKYDDSAFSRSNSLHYNKKCRTVSTENNDQSISKEGITIKNDHTEHRNLLNEDINLNKFDTTKKTCSQGKTKSIDIKPINCEDKKNQEEIKTNNPKEQIESNVKISNTVKKEINFSELKNLRSSINSIASSNLRKTPTISNIENDNYSIPPKYIPEYIKSFCIFKDNHKKDEVSRITPLIDHVNSNNNDIGLITPKNKFDTSSLNKDIKMNNNDHEFSVDECLMKCLKEDPSKFRTNEDYERFCNEDKILNPSYVPHESRKLGENFLKNKKDNFSFINKNYNYEPNVNIAECGNSSFNYDGGFNDPHKNYFNNIKINVFNNDYVNNDNNCYNNNSIYNNHNINSINNLNYMKGGNDHYNNDIFIKYYEKYSIKNLDKNESEKLNYTDCYDFKDSSLTEISKDDSFCSDDLGNDDNDINCLKESLNSFDNLESTEKKYEQILKDFNGKIPLLHKVLKPLPVKNRSNNFDICLYLLQKHGGDLNNEENICILRDREIVQHSAIYDTKNNCIKSNITNVTNIKLYHPKWYNKKKIIERLKEQSCYNPFTIFGSAPSLLDFDEVFDKDVYNHFVSKNSRKNHSLLRILAKQKVISNLNDKISDKEWPQVHSYLKKRWSRETNIELNWACDPLLYEELEWYLSTNNEYLNMTDKVADIDVCYCPTLDPSSYYAWNDSRVIYTNLCYNKSKDDGEESNNDSKNMYSTNKSLEFKKNDKQLSFRKRASGCEHLMFQQNVMKQKKLSKKKKKLLKKKKKMIKEKYKTMDIDVNFGNYGNDNNREDGKIIKSAEGFSYPYKNMSNYHENKTDYINDQYMNDFKNNKENNSFYYSNNIISKNKKSIYNHKNCEDNIVPIMAVNTSLYRNNMDNKYNCHNTAFDYIKNKDNTIKFFASPKKKKKKSFKKSINSDCFDFINSSMTNSDSMHPTNNNNENSSHNIGNNNNDNGNPDFNCNDTTEFNEFNDFSTYNNNKNNFHIFEFNDSIKCNNMKDAYNKDMMLNEDNLKKKHNQKNYEQTGYIEEMCGNKNRQNDCELLDINENNFEKNNMHYFKSNTYMYDINNNNASGMKNYIAKSNDNIVYKSNYNMNQGDISQSFYKNNGKNNNYGNDNNVKMTMFRNMQMGQNEYNMNYHKGNNNDNNRNGDNCNYRKGDNQMSFIPRNFDDKNDINTYYKVYNASDNNSNHNFHKNIYGNKNIYVKSDSRYVSNDYNKLKGNELSKNEHISNNIGHFEYKSSNKNFPDQNILNQKDNINGLKEKYINMCKEEKQLITSSDHNQFNFFESNYENYNNNNDDNNERSNKIMNEYFHSKNPENYIQMEKKNKKKKQSNDTGNSNNTMENHQNNNKHINKNLRNIIPETNILKLTQENIDKKNIIENEIKNSNTLLYKKKNNNNNAGISTSSFNSKRLSNSNISANENKKIRRYVNKMHHDSDNVSIEHSENDKQRNTSKEIAETPSSATSETSMSSAFKMATSVFKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTB4</accession>
    <name>V7PTB4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1425"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1550"/>
            <end position="1562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1576" mass="185128" checksum="916212F94690238F" modified="2014-02-19" version="1">MISKFYFKTIFKNRNCTQKKKNSILKDSYNSYNSKYYDSQSSSKLVINENSNNVPKHLCHEKNRIKSPLSSNIHDNFYYSDNYFSEKPRKSEKKNNNNRTKQNNKACEVSLKNNNLITGKKNNITLAKNIKNNDQSISKEGITIKNDHTEHRNLLNEDINLNKFDTTKKTCSQGKTKSIDIKPINCEDKKNQEEIKTNNPKEQIESNVKISNTVKKEINFSELKNLRSSINSIASSNLRKTPTISNIENDNYSIPPKYIPEYIKSFCIFKDNHKKDEVSRITPLIDHVNSNNNDIGLITPKNKFDTSSLNKDIKMNNNDHEFSVDECLMKCLKEDPSKFRTNEDYERFCNEDKILNPSYVPHESRKLGENFLKNKKDNFSFINKNYNYEPNVNIAECGNSSFNYDGGFNDPHKNYFNNIKINVFNNDYVNNDNNCYNNNSIYNNHNINSINNLNYMKGGNDHYNNDIFIKYYEKYSIKNLDKNESEKLNYTDCYDFKDSSLTEISKDDSFCSDDLGNDDNDINCLKESLNSFDNLESTEKKYEQILKDFNGKIPLLHKVLKPLPVKNRSNNFDICLYLLQKHGGDLNNEENICILRDREIVQHSAIYDTKNNCIKSNITNVTNIKLYHPKWYNKKKIIERLKEQSCYNPFTIFGSAPSLLDFDEVFDKDVYNHFVSKNSRKNHSLLRILAKQKVISNLNDKISDKEWPQVHSYLKKRWSRETNIELNWACDPLLYEELEWYLSTNNEYLNMTDKVADIDVCYCPTLDPSSYYAWNDSRVIYTNLCYNKSKDDGEESNNDSKNMYSTNKSLEFKKNDKQLSFRKRASGCEHLMFQQNVMKQKKLSKKKKKLLKKKKKMIKEKYKTMDIDVNFGNYGNDNNREDGKIIKSAEGFSYPYKNMSNYHENKTDYINDQYMNDFKNNKENNSFYYSNNIISKNKKSIYNHKNCEDNIVPIMAVNTSLYRNNMDNKYNCHNTAFDYIKNKDNTIKFFASPKKKKKKSFKKSINSDCFDFINSSMTNSDSMHPTNNNNENSSHNIGNNNNDNGNPDFNCNDTTEFNEFNDFSTYNNNKNNFHIFEFNDSIKCNNMKDAYNKDMMLNEDNLKKKHNQKNYEQTGYIEEMCGNKNRQNDCELLDINENNFEKNNMHYFKSNTYMYDINNNNASGMKNYIAKSNDNIVYKSNYNMNQGDISQSFYKNNGKNNNYGNDNNVKMTMFRNMQMGQNEYNMNYHKGNNNDNNRNGDNCNYRKGDNQMSFIPRNFDDKNDINTYYKVYNASDNNSNHNFHKNIYGNKNIYVKSDSRYVSNDYNKLKGNELSKNEHISNNIGHFEYKSSNKNFPDQNILNQKDNINGLKEKYINMCKEEKQLITSSDHNQFNFFESNYENYNNNNDDNNERSNKIMNEYFHSKNPENYIQMEKKNKKKKQSNDTGNSNNTMENHQNNNKHINKNLRNIIPETNILKLTQENIDKKNIIENEIKNSNTLLYKKKNNNNNAGISTSSFNSKRLSNSNISANENKKIRRYVNKMHHDSDNVSIEHSENDKQRNTSKEIAETPSSATSETSMSSAFKMATSVFKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTC0</accession>
    <name>V7PTC0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 61 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038884">
        <property type="entry name" value="CFAP61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178:SF8">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1534" mass="184131" checksum="296982CE50220A70" modified="2014-02-19" version="1">MKKKYLFVEFKQHILKSIKIESIKDLEKNYEIENKVIYDYLNDHLIKDVDAYFEYFKNKNLNISSTIKNIYNKMQYDYENLKNNGEGDSINFVQLNKLINLYAHISFADISKVSKTFYDNFEKIEILYFNFNNDKTYKKIYENIKKKKEGIIGDDLSENNTKKMNIIKLNYDSSVKKTEREYKKVVNLSYYDIFLLLQNIYPDIFKTNEIILLFLFLDLYEIILVTESTIFDCVSFKTHLDELININKNYFIYKYKHIDWLSNLRDDDKNAYSLNLFVLNDKYYSNSKEILLKIEKICFKEVDYIIATNNERGYIPFILNYFNMIKKKKKANTLESLYILNKYTLFLPPITDYMKISDIEDVQNFLKNCDSDKKNEIIHTILSLKKYCKNKMDTEKTVYSSDAHIWELNFYQAQNYYIFVSRSGNSIINVTSGRILNNLDFYYKDKIYDFKNIIVQNENKNTKHFLMSFFSSIIIFKYYDKNVIHNILRLIKACSCHVEISDNRFRDVYKHFKILKKKDNKINIIKKKKICDNKKCMETYREEEKKKKKYLIITKQMCSKKSINIDNNLVFWGINDICLYTLYKILKNNEYIFNNIIIIIRYKNKYLCKNVIDKYNNITNVSLDRLTIYNNLKNMMVSDRIKIIYDNVYNIDRENKKLELSQKKWIHYDYLFLCFDKEDITTYSFDIDSYQIGKKKNFNFLELSNHSLDKNEKLDFLVKAKDYQKYENCESCKNCESCENCEGVKKYKKKKNENCRDNELEKEKEKEKEKEKEKYTTSESSDIYDEKIKPKNKTFQINENNEIGKTPKIKKINKGDNPEITIKNENEKEKDYYTDYYTDYYTNYYTNYSTPPSSCFDTSEESSSCVKDILNDGKQSANLKGNNEAKKGMKKETKKETKKETKNEMKKETKKETNKRSINGVFSISDPMLEKHFDEKSKYMKIVKNGVNYIVIYSNNLDILSIINFFLKNKIKTYKLIIICPYNCNKCDRENMKEMKKESVEKDNDKNDGGCIKDYIFKERGYYKNKEDLKNNYLFLNNTNLSNNYYHKNCVLKNIKYALNKIFFLFHLLKIRIIYGQIIAIKKNKDNKLKNIIVRFCKHKKTDQSLINQKNIIFKNFIILPCHILLSSYHFDMNNHLNYILRKSSIVYNQKICLNHNFQTNDKFIFSGGDLCAFSNKYRINKNRELNHEYYNSVEIGKMASKEILKIVLDKCRIPYNVLKLKKKNKQMENCEKKNKEMENCEKMKEKKIENCEKKNKQMENIQNKCDDIFYYYKKLKVFEKPFVYFNKLPCDFYFYYFQASNGDLCKYNDLLAPQSGEENIKPNINENNDNSRQFKQVYNNAFCTDTLKITIKNQPELNEKFNVKYFDISKNIHAQGYYCRITTNSLNMINSFTYLGREKLNFYNLSNLCNLSINYFYTIVKKVQTCNSLNYDILSMMNEEREQFIFYYKFQEYKNKLKEKIINTPHMKESIQLLIKDAYDKDVLKTYLEYKNSNVEDNDVCKNIKKHVQIHLIESIKKNRDLLNGYYMPTCNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTC5</accession>
    <name>V7PTC5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BUB1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_01674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTC5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="139"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="8">
        <location>
            <begin position="280"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="9">
        <location>
            <begin position="505"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB61872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="96154" checksum="2C481C82A1715D87" modified="2014-02-19" version="1">MDELGNVYDCDLLFNDNDEDDINLEKDENNCEDTTRLVNEENESYLKNIDFDIKNNMDKISTQYLFLYINTYKEKNIKNVKKLYNLKFYDIHLRKDEYPLLETKHNVIEYCIKELINKENEKNKFDTIQNNDNNTNYKDEEDKYYLLKIYETILKHFPYSFKIWYYYIKDSIEMVSDIYYNNKKEYEKINKIFEKCLLYLYNFKSIYIMYIQFLYIQRNVKKIREVFNKSLQNVCLNQHEDIWNYQLKFISKIDSKLINYEYIKRYVTIYPEQVIFLFNHYIKYKMHKQALSTFFYILNNDDINFDLGDKTKYDLYKEIFNLINSSKTLNNDVMEILRKNLDIFKNYENITSLYILLANNFVYEGRWNKAMDIYEEGISESYSINDFSVLFDNYIETLKILIDLKIRNHDGNNIVQLANKNDQEEETDEDENEMNISDDFIIDLYMDKINYLLDKRKIYIADIKLKNNKNNVYAWLNKIEIIDNENEKINIFNQCLKYFQDNDYIGKLSDVYITYAYYYYNNNNYKDSVNVFKKAIEDKNIKNLNEMANIFCSWIELEILEQNYNEALQIARSSIDFDKNNNFDKKGLQIVSYNSDRNSIRKDNTTYGFQNVQNKFNLKNSIKLVCLVLDMEINYGTVETALCMFDLLYHSKSITIKMVLSFANYLYEQKYFNECFKVYEKAISIFHYPYLYPIYVNYINKYIERYKDKNISYVRELFKQAIYGTDNKTYVPKEFSKYIFLMYISFEENYGFLKKSLSIYKEAIPFLEEQDKIKFYKVFISKVRLYLLVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTC9</accession>
    <name>V7PTC9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTC9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="290" mass="34358" checksum="1990626E35F31C9C" modified="2014-02-19" version="1">MRYSKTCKINNLNYENIEYELLVSFMNTFNNKIKFHLKLNNNDMHEDKENSILHKMVKIFSDKLIICCTNPIIMFTQNNDNNSLFDKEIISQVSSFFNQIEECEDFENLFKNCLTTILEKIFNFKPNADDMATWVSRQAFVDLVKIIIEKSAKRNEQCIIYTANIIKKNYTNLGFFQVDNVVVLIEIIQYAIINLSEHKYNEKCISFVNEKWFESLQDLMISLKNCEWKIFLNQLIVIETFLCDKKRQNTQKTFNELHKQQVELSAIKNSSYSKWFKIELPLSMSLFKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTD4</accession>
    <name>V7PTD4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1409"/>
            <end position="1419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="2072" mass="243408" checksum="CE3A6F81B3A29339" modified="2014-02-19" version="1">MNINKFNSNTKIKKYELKSNYNTLKTNLVNNDKNCHDCIHPHNNINAKHIDFYVFPSNDNGNILKSSNGVLCTNTFHKNDNLKNKTIINEFQINAHNYNNNNINNENVPNNMPYTHCMNNTIGMNNSYNTIHNTFNRTSSLSNVPNKNVNNNNLSNSVNAFDNVNKNEYDIFYRKQALDIFSWSNDVLLQKNYVNKSNLCNNSQSNNINRSEYKKSIHKENFYDLNRIYNSNEVSTFKINGNNEIHMRHSYKHNIYEKSMSKEYSNMSLNSYNNVNCSTFLHLKQGNNKSYYDIDIETFIGENYDSYGNFNYSTSNFNANSNLTISEFRGKHENITHNCAKNGNIGYTVIKNNNNFKQYNSLEEKHNIYECEHEWKQVLRLKNAQKNKKCSNIPKSEKSNIIPHTKMDSKQLNLSNMINYMNSQKNNTQNKEIIQKCNDQAINNNINFIYDHQYNIKNKNININPEVNILDFDYFDNFHYFLNEKAPIKLDTKLINENDLKSEKNGNISNYNSYITIYHNNSSNNNNCVCNICHNENVMKKCVQNSNKSNMEISKQIYNYNDHQNCKNYNVMHLNEYTTPNDEQNIILNESMNYNNNNLALKKKSINEQYAYNKRDFCMNSNNFKDISKKIYIPPPKNTVCCQKDLQNNIFTKNSICKSNDAYNIKNSISKNIYSTKNVYNDEKYVTSMNILKKTAVFEKSPSHNIVNNDYMNKNVKVIFQNYKTTENNSNNEIIMYANEKYVKEINFPLQNKGDVEITKKNINDNFISSLETHNHLKNDFNKIKYNIGEFRNSNEEELSFNISKYYLQNNYNKMTCKQLNLVQSEVNNIEKGRHGEMYELLEIYDKNPNINIPKENEMDEFLEIYNQNRNMVMSKDNEIDEFLDIYDQTRNMDTSKENKIDEFLEIYDKNNGLNRYTESKMNEFLDIRDTVRSIEEAEQIDKARKNFENHDKIIDTHETLSVNNLSSTYDHIKDIEENKDQSAYKYKNNIEDLNKNELLEYWGNYHYDVIKKDTPKHNNSFIYASGKEAKINKDVVKEMRSKLFSDDEHDSNKNENKGFSSFTYASGKEAKINEDVVKEMRSKLFSDDEHDSNKNANNGFSSFTYASGKDVKINKDILKEMRSKLFSDDEHDSNKGENKTTNENKTMNENKGFSSFTYASGKEAKINEDVVKEMRSKLFSDDEQTSNKNEHKGFGSFTYASGKEAKINEDVVKEMRSKLFSDDEQASNKNENNGFSSFTYASGKEAKINEDVVKEMRSKLFSDDEHDSNKNANKGFSSFTYASGKEAKINEDVVKEMRSKLFNDDEYNNYPDEMKNEKNSYFENEGADIKKQNTLLEGRSSSGNSLEIESYAKGKEGLKEVKQNKSTNNKKGIRVKRMKVKSEENLSCGESYSPQKKKKKIKSNNNNRTNGDLESNKNSNDEMFVEITPYKSEGFDEIMEKEKGTNYICSSYYDMVQIKDTPKKMSSNLKSKNNFINPRKQNVNNEIEEKQTLHNISSNNKENSKLDLNINLKDSLGLIKKTLTNLSEKRRLKDTNFFTNFLIFINEENKKKPYEFNWFNNDYIYFLKNANQKEYYVSNINVMYELFILVTKELNIFYIYDFPWFLKKYNLITMSLVRKYKKELKEKYKCLKYMMTMFKSPRSDFNKFVDNKEYLNPAVRDSFNDRNGILENEAENVNSIIIKTEREKSSIYNKFEKENDNHLLDKIRNNYAHISNFNLMDNVNYYGNNAYYTTLYKKQANIFKNNASYNNNFFEEYNINKSYMYENYTNKCGNNIGCIIPYNSLNLDITMINCIDQVPPPSPIEFIYKLLKKYIEEQKNKKSVLQLIQENTISYKVPINLRVEKIIKKEEKYIVILSDNFDYIYCIIKDTYLVELLICGKIKEGYTLKINSLDVYNDNNVIPHEENPNSYLRGINFSLSSNNLICIDKENKLKIGLSKYKSKRIRSIKDFENGCFFIDVVIISKSDFSYGFYDQTKKQYYILNSEIYEKTVYDLKNEMTKLMHDENYHENSKYIKLKNDLYMFLEAITLCTIQAIDFASSEKIKETDLLDDKLEKIINSLCQIKLIKVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTD6</accession>
    <name>V7PTD6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PTD6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="264" mass="31594" checksum="80B59E2C0AB86F63" modified="2014-02-19" version="1">MNEKARDAVFEKKNEEMTTVLNKNILFKEYNNANDLKDTFINIKSDYSIESEKEKNNISLFNVLKKKLKGEKGCTRFLIIFKISNDENENKTKINDIIKNIIKEKYETITGVCLFVNIYFIILLESPDTKNVFNLLHDMTNIKYISELKILYFSELNKQKINEDFYFFEYKIEDQKGILTECNFVDEIWDLYINILNLCCFIKDNDKKDIFEKNENLKKNFSTLSNFYTNIANEYIWKIDEFFSFFTNDFNLPIDSFTDDFLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PTD8</accession>
    <name>V7PTD8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1355"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1751"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1860"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1760"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1860"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1885"/>
            <end position="1897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1911" mass="224161" checksum="A482BD3EFBBD152A" modified="2014-02-19" version="1">MCIMLVVTESTLEKQRNRNYPRNSQIPSKNNSTQIKVIANRITPYCKDILKTERETIKTRKFIKDYKTKYKYIFSKNNTDNSEREKKAKLYSVEKKANLFQLKKLSKSKKKNQVSANRVNYNCIVNNSHIKNSDQEKNSYQLHLKDKKHKHLNKKSKKNLQSDIRDILLDNPNHIYGNDFPNLNTISNNNNNNLKNKVKTNNDILYNKNVTSRKSNASYKLIDNSSFNTPCIDNNINDDDDVFKSYINDSISKKSLYSPHCKHKITTNSLIDSIVSLSNDLNTSTEQKDNEYDKNLLSYVNKILHDNNFYHGISLGVNKTELKQLESEIHKKCNDMISKFYFKTIFKNRNCTQKKKNSILKDSYNSYNSKYYDSQSSSKLVINENSNNVPKHLCHEKNRIKSPLSSNIHDNFYYSDNYFSEKPRKSEKKNNNNRTKQNNKACEVSLKNNNLITGKKNNITLAKNIKNNDQSISKEGITIKNDHTEHRNLLNEDINLNKFDTTKKTCSQGKTKSIDIKPINCEDKKNQEEIKTNNPKEQIESNVKISNTVKKEINFSELKNLRSSINSIASSNLRKTPTISNIENDNYSIPPKYIPEYIKSFCIFKDNHKKDEVSRITPLIDHVNSNNNDIGLITPKNKFDTSSLNKDIKMNNNDHEFSVDECLMKCLKEDPSKFRTNEDYERFCNEDKILNPSYVPHESRKLGENFLKNKKDNFSFINKNYNYEPNVNIAECGNSSFNYDGGFNDPHKNYFNNIKINVFNNDYVNNDNNCYNNNSIYNNHNINSINNLNYMKGGNDHYNNDIFIKYYEKYSIKNLDKNESEKLNYTDCYDFKDSSLTEISKDDSFCSDDLGNDDNDINCLKESLNSFDNLESTEKKYEQILKDFNGKIPLLHKVLKPLPVKNRSNNFDICLYLLQKHGGDLNNEENICILRDREIVQHSAIYDTKNNCIKSNITNVTNIKLYHPKWYNKKKIIERLKEQSCYNPFTIFGSAPSLLDFDEVFDKDVYNHFVSKNSRKNHSLLRILAKQKVISNLNDKISDKEWPQVHSYLKKRWSRETNIELNWACDPLLYEELEWYLSTNNEYLNMTDKVADIDVCYCPTLDPSSYYAWNDSRVIYTNLCYNKSKDDGEESNNDSKNMYSTNKSLEFKKNDKQLSFRKRASGCEHLMFQQNVMKQKKLSKKKKKLLKKKKKMIKEKYKTMDIDVNFGNYGNDNNREDGKIIKSAEGFSYPYKNMSNYHENKTDYINDQYMNDFKNNKENNSFYYSNNIISKNKKSIYNHKNCEDNIVPIMAVNTSLYRNNMDNKYNCHNTAFDYIKNKDNTIKFFASPKKKKKKSFKKSINSDCFDFINSSMTNSDSMHPTNNNNENSSHNIGNNNNDNGNPDFNCNDTTEFNEFNDFSTYNNNKNNFHIFEFNDSIKCNNMKDAYNKDMMLNEDNLKKKHNQKNYEQTGYIEEMCGNKNRQNDCELLDINENNFEKNNMHYFKSNTYMYDINNNNASGMKNYIAKSNDNIVYKSNYNMNQGDISQSFYKNNGKNNNYGNDNNVKMTMFRNMQMGQNEYNMNYHKGNNNDNNRNGDNCNYRKGDNQMSFIPRNFDDKNDINTYYKVYNASDNNSNHNFHKNIYGNKNIYVKSDSRYVSNDYNKLKGNELSKNEHISNNIGHFEYKSSNKNFPDQNILNQKDNINGLKEKYINMCKEEKQLITSSDHNQFNFFESNYENYNNNNDDNNERSNKIMNEYFHSKNPENYIQMEKKNKKKKQSNDTGNSNNTMENHQNNNKHINKNLRNIIPETNILKLTQENIDKKNIIENEIKNSNTLLYKKKNNNNNAGISTSSFNSKRLSNSNISANENKKIRRYVNKMHHDSDNVSIEHSENDKQRNTSKEIAETPSSATSETSMSSAFKMATSVFKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVC3</accession>
    <name>V7PVC3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVC3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="14560" checksum="14D06235E3DB442A" modified="2014-02-19" version="1">MHTHIYVYIYIHCFIQNLMQKCSYIHLERGLKLTIQKKSQEPCWKRLTKEKKLNFLIKDKSFGDPNDCEDAKHTWLLDYMFYKRKTNPIKQDEPNKKNDPVQNIIDNLKDSQSHFSIHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVC5</accession>
    <name>V7PVC5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVC5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="253" mass="30585" checksum="90DC57DBF1CCE4D3" modified="2014-02-19" version="1">MKDSHLCKFDVNYFLKSCIELEKSYEHILDEKKKNELNFSDALKNINCIKEKYERERKNNLELSQYISKYTDELVNKQNCTENYEIVKKQNANYKKKIENLKKEKDQEKGSLEEKIRNMENKYSKELELYETQTRENVKKLKELENKHTELRSQISSKDLQLNKLFSKLKEFEQEQEKVKLKHELEISNLIKSNEENIKKKKDNIKEIINNSENLTLTHLKNKHKLLQKVIHIYIFIFIYFSTQIMSHTLKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVC7</accession>
    <name>V7PVC7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTMP kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_01813</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVC7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="9">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB62088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="159" mass="18233" checksum="496B5BA5E5095087" modified="2014-02-19" version="1">MDNLNENINTNLKRGNFIVFEGVDRSGKSTQSKLFVEYLKNNNIQVQHLCFPNRETTIGKIITNYLKMESTFSNETIHLLFSANRWEMMDQIKNLLINGVWVICDRYAYSGVAYSSGALKLPKEWCMNPDKGLIKPDAVCYLNLPPTHAKNRSEYGMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVD0</accession>
    <name>V7PVD0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhoptry neck protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_01821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1976"/>
            <end position="1992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="729"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1474"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="729"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1480"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1514"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1546"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1586"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1598"/>
            <end position="1607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2020" mass="238287" checksum="3C91CCFAE5B8362A" modified="2014-02-19" version="1">MKNTFGSIISYVFKSYLTFFYPLIVPFRGAFSFILSSICLMQFGKIVHMIYKNLKKLYRISRRKFYYAILKVNLLRQPQIHVYAMKLLYGDALVLVSKIWKLSYVNVTDHLKGDEMSPILNNLFEKNLGTGFFDFSESLFKYVVKSLNEMNILTNERANFEDENEFKNETIINVLSFLTVTRRALYYEEAYMRIVVARILAKFYTLILVNINEISKIHPKEYFNTDIESTYASLYQKQMHQTNLQKIFSDITTKPFIKRNLRKINRGSIEFTMSLLKIRLFHYKSSLKHPYSSFYFDEKLKKHLNNAMKLIISGSNSIIGDLVKYGERFNILKECPIEIATRLGRKCNNDDFEIKKLLFPLNIFINLLIPLYMQPEDVLINDKIIPDILNFFQVMTDSKDLYLYKYLTSVVDFIFKNENVETSNIDYHAEINKIIIKEIHNVIEEVNNEKINSLKFHAYSIKKNDLFLHNTNGKLFKFTFDKENDKRYFSNLLKITDYRDPLEYQSPYVNFKPLISNNGTLAIQNYHKKFKGKIYTCHMCLDEDDDILVVNLIYHVLWSSGLDKFSAYVFSSLIGAVKQMYHKASPWNKALIDMVPTEFYHVHSIFMNKNSQLKNKSQNVFIKRIRYYGFHFNKYTFQSMFKSLLSNILVRVNFFDLEQAASMISMSLLYSIYTHIQKYELPLEETFKLQQQKIIESYYTVDKYSQNYEAYTIEMINEAKKNKKINMENNNTITSDNNSSNNNNSYDDDSDTTSNNSEVEAISTNGTKETEEDVELSLDDELVKNTKYLKLELESKEDVRNKIIEELIETNGNLPNYEMYPNLPAQCFFLLYYDFTPFIQNNLMGIENVINTLKNTTLGRDHIINSDRIQNETTLFASINQKDIINILCGTHLFFKKEDVTLNEMFKYDNSDIAVNHLLIYLALLRIEKKYNHLSWKRYLILEKYLDRRRKFYKTPLKYLRLKILNYKRTLARLRRKTQKYMGMMLKKKNVFKPLTAQANFELMQNAEIYNKRYPLIYIRFEDILTHSNVFHKFKYTLLKYVSDKETIRNMINNFKLAPDTSLNNNNLLKRIFKIFNLIIYHKFNIDLRDIGNKQQYIKSDFVNMNKTKYILNFIKLPLEVENYLNQLIGFLKLLTDMKFTNFLFLKNFYIFIKLYIVTGDFEFASKDSVIYIASKNYLNFILNSMLEFENFKALFKSLNNINLNIRKYPLNYLNFKAKCYTIDGHNTYDIIINDHDKAEQIFKIMNYDIDSFYKDYLLIDLLYDDIKFVDISPYYETIEDGKLSRMRNKLSKLIPGAKNASQFLAFDDIKMLNDSLQNFAYLEKFLENTNIPLIPFSDFSYSVDGDNVRVYFKTKATSAPFYKENILDLFKHVGKSFVSNYDQKVKCSFVNYPFNLYYWLILNPEKPNVETINKTGLIKEEDLLPQSDEQKEKTELLSDENLVKDILFNQIINKVDNKNDDNLSSASTSIKSFKYGTDSDSESEYDSEYENTSNSKPSDNLTRSDKTNIIKPNLNTQEDSSNESYLSAQDTRDSETESLYEDSISVANSDSIIPPSTKQFYSTPNDAVPLINTNEDNDQSNNNGENDENGENGENDESGKNGENDEKDKLLHQEHNNDNIANYDNENTSQINNLNETETNNPTSFIQKSKTGPFVFDSIMISEKINTTTQDKYGNFGRPYNIYIPKKDILRNFHLVIKVVHSLISLNKFSIVNPKNILKKGIKILTNDNDFIKSQKLNPLINTMLLDINDIIQKLKLTTEKQYNVSNADILDIYNVIEFSLFNKYIIYPPLKRLNKNELNYILNVIDQGYFYHFMKIVSKLKGVNIDQRKVRNKIISIQEYVPLLEESNIDDFYQIIIDSLRCENIKCFNFLFNDFIMRMYNNNVLRVVNNYDIITPMKDIVNDQFGHIDDILVKVTNSYTLYKKNDNPFIKMYLDEHSNSNSKLNYTELLFGALNVSQQMDKWLSLYTLFNIRHIYLNVGYMLVGMKYIIKRKYRMFAHKYMFFKWLRISKKQQLYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVF0</accession>
    <name>V7PVF0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVF0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB63100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="543" mass="65012" checksum="EBDA03E106B0EBE3" modified="2014-02-19" version="1">MNTIKGKISNEKKQTPNQNYEDKSVEEIIITILSEYITDYKMEKENDNEYVKEHNKKIKDISKYHEFKLYEDKAGDNLYANFQSICFLKEYDVIKNILDTLKNFNENFSILLSLHPDKFFHIWKLFFPVISSSTCDNEVFILIMDYLKQLLNYLYIEDLTTKEILCHVILKSLFIIDKDDYKDARCFCELIILIIKNDKHILMNILNMIKNNMSLNFFYLYLSKLLKMSTNWVLYEKDIKDIYLYYIFIGLHANKETIILCCLDMLSTISMHENCYDILPFSSVLYNILEMKNISYCIFTFVVSANIVSKLIGNDQNNSGHNAHINEFIKICYTILENTKRKELLYLFLLYSYKIINKNDDIYEIYFMKYSKLSDEELKHFIRNNIFEAYLRNVSSFKIIKKYFSNIFNNNINELNKECNDTILNSLLTKGKFKEDCFLRILKEYIIYYDNMETTKYLEIYNKIFEDLIENLFSDQHTTFELSKDILNIFWLSSNPKLKVKYFEISVNHFKKTLLSNKHNMHSHTKEYIGILEQDTNLKELIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVF6</accession>
    <name>V7PVF6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_00320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB62607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1691" mass="201538" checksum="EEB44FBBC148DEC0" modified="2014-02-19" version="1">MKKTNMLLPKRSEGIIKKKGKLFFLSIKRYETTNISIQKNDDNINISVEKKEDIKNDNFISDNKNDGNAKRNIGNDYLIKYHDENKNIIKTTNYILKIHLRDNIFVNQKNNFYNYFYNSYPFIINNYISQVKGNYLSLNDIENENNRNKKPNDTPKQKSNYEIEKLLHTFLYYNKDTKNSLEDENFLNIINNKMNNLSNASELLKWLNKNMHLTILKTGTNQNEELSNKIISKEKTKLYGKFSKLFQNIINHINDTNDMNKKIEILLYLINICNKNVFPQIYEQAKTCLEGIYEKIKGSQKKNSKKGIEQQYIMFLLYKNFLSKNVEKYINMELKKYLTEEISFYNYLKNENINICLLSLIYRDLSFINNYEIKYVLMNLAFSKIKNTDMFVDINNSYNAIMPMTNLQSYTNLSRDNNSYAPILNNFQEGKNNITQKNKKNNIFLSDSYLSFFSNTLLKNNFYTFLKNDYIYFDATNKFNSQTDINNTNINNYVFYNLLVAIIQLKETHLKLCDNMQIKKMKFFLENEKNTTLLNFICKIKNSSYYFNDFIIQNITFFTKYFVKHKINFPNNIYPYILSIYCNLIDNMKNIENYSDIKKGKNLINDSKHIVNYIINEIYYNINLYTLKEYLSLIKCIQILPKKYMFELKRDIYSSRNRDKLNSHSFYNDELDKSNDKLNLQNLLDLGTTKTEKKDEQVQSSNLRSNNSAKIESIQKVMKNNIFPNRHMDNLIKNNFKTKKSVTIISTTDFIGLTSLPIFNELNEDFVLKIRQNEQMKIREMIPNKLSNNANVTSINLDNIYEYIYTFHYKKFVNNSEDYIKNISIKYDELTKDQIINYFIFFTHLNELDISDIYVLINIMNQINVFHPFIDFFISKRVENLLQTKWKNEEINIFGKLSSDITNKNTLNQYKFSDTYLDDYITKMKKINEQDNFKKKESTNNKNNVNLNDDNTHEGIHSQEFLRKNIDNSQKHFNDLNLYNHNIYASNFENINYNYDITTNTINLFLSLNSKYKTKHIIEKYLKFFHFENINLFKINFNYFIQKRNQETYSTTKTSIQSLNSIAMTSKLSDDILVNPILSGMLVYPDTIEDRGSYKIISETYNNTFDKLNIISNIDTKNDGIFCLHPNSQKMDTGINHKIIYDIIESRIKYDINIKNFILNNENKYNEDIKQNLEKDFLSINNIINLISYLNNINDDVNYIKLLTLCLKNIILCKNEIIDIKTFRLLTNELLNIKNIYQNIYISSEYSYLNMLIKHYIKIMENFIPFFDISDYFKVKQIFIKYSLSNKYLKPLIILNNELNKVSIRNINLNFIHIILQFYLKLNFINEQFIGNLLHHYVNFIYQQMENIPNTTIISNVIKTNELLLSLCIKNKDIINLNFVIAQRYTNYMNEFKIDDSNMSNKFSNTEEAYNILEYNLSNSKDEISDQKNEPIIEYEKDNGKSYDNNIFNNVEKETEGDIHNNTNKYSINKEINDDIIEDQTIVGHNNKNNHSELIHIQNEDDNKNDAIVQNKKYELSLTHKLNIIYFLCKFHFYNNIIKSYYFQLINECLNSESLSFNDEEYCRLYEIYVHVILNFYFLSFDKNNKYINYILSNLPCYHWYKKEEEKLNLFTASKDYTDINTILRILNLNFLTPTLTEIYFIHFFNDLKKINSIEIPQNVFHLYQKYNLLIEDIQNKNVAILCVPEENALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVG5</accession>
    <name>V7PVG5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVG5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="264" mass="29988" checksum="256B6CC98380E115" modified="2014-02-19" version="1">MSKEYYSIKKHTKLINKIDCKNSKNNNIIVTGSRDGSVKVFDIRTNNEALSLEPPKDSPYIPDCWCVSTGNNYIEENTFSGNYHENLNICAGYDNGDVKFFDLKMVSIEHEVNVNNGVCSVNYDRKDTKKNKLICSTLEGNIYIFNLDVYSEGYGYSHSKDQVVSGTCWDTPFLPQNRDIFACLGGDGNLILYKYINPEKNFVFDELKGYKKGIVGELDKLNHLNVSTQPIISFDWNKDKLGLCAFASLDQTIRVYIITKLNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXG3</accession>
    <name>V7PXG3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXG3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="302" mass="36026" checksum="3C80E74DA3604A6E" modified="2014-02-19" version="1">MIKYILKALTNRELKKTILEKAQKVLSERKNIINEKNTNLLNDVETNDKDSIHCCNENYEESELGNKDIISLDDKNNLNPENKNIHFFNLQDFSMRYSKTCKINNLNYENIEYELLVSFMNTFNNKIKFHLKLNNNDMHEDKENSILHKMVKIFSDKLIICCTNPIIMFTQNNDNNSLFDKEIISQVSSFFNQIEECEDFENLFKNCLTTILEKIFNFKPNADDMATWVSRQAFVDLVKIIIEKSAKRNEQCNIIKRINKCIYFLYGYKYIVILTFYVCINRYNIYSQYNKKKLHKFRIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXG5</accession>
    <name>V7PXG5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">YYC_00141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXG5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052298">
        <property type="entry name" value="ZMYND10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244:SF7">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="300"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETB63322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="366" mass="43391" checksum="83A13DFCFB72D4D4" modified="2014-02-19" version="1">MAVLNIFELILLSDHIYEQIDTYIINLFAYIYSNLVSFLKTSSDEYFVKPITELPISEILKEENDKTHNIDRLKIYINVINTLRNIIDRIHLLNNTIVNKIVDYDILLILIPLIEKKPWKHDNYIFEQNEWIKNEDNAMATVEKQLWIILYTLILNSICQEKYEMTNYRRNNILKLRKYMNENLYEQLPPMKTLHTFIEHLYISKSVFPENKNSYLIIDVVPEIFDEIKNDILKNKKQVLSMLNNITISKEVLGSISEVYLSVYEFDHQIKKSKKKTKEINPIDTNHGEKEKPIDNQYTCNSCKEMAELQCSQCKQAYYCSKECQVWSIKIEVIKICVLTYINCVNKIKQNKYIFVCILDEGLVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXH7</accession>
    <name>V7PXH7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1556"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1665"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1565"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1665"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1690"/>
            <end position="1702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1716" mass="201332" checksum="62FD1B9BDE6141B6" modified="2014-02-19" version="1">MISKFYFKTIFKNRNCTQKKKNSILKDSYNSYNSKYYDSQSSSKLVINENSNNVPKHLCHEKNRIKSPLSSNIHDNFYYSDNYFSEKPRKSEKKNNNNRTKQNNKACEVSLKNNNLITGKKNNITLAKNISKENINYKLTLDNDKLSVNYLKESHLHNNLKSFNQNFKPKKKRSIETQLTLGNTVTSSVCNNVDIKPFKYDDNNNNKDIVHDSYNSVNKLNYDGIVNTNNQINHVNKQLSTLNNFEKYDDSAFSRSNSLHYNKKCRTVSTENNDQSISKEGITIKNDHTEHRNLLNEDINLNKFDTTKKTCSQGKTKSIDIKPINCEDKKNQEEIKTNNPKEQIESNVKISNTVKKEINFSELKNLRSSINSIASSNLRKTPTISNIENDNYSIPPKYIPEYIKSFCIFKDNHKKDEVSRITPLIDHVNSNNNDIGLITPKNKFDTSSLNKDIKMNNNDHEFSVDECLMKCLKEDPSKFRTNEDYERFCNEDKILNPSYVPHESRKLGENFLKNKKDNFSFINKNYNYEPNVNIAECGNSSFNYDGGFNDPHKNYFNNIKINVFNNDYVNNDNNCYNNNSIYNNHNINSINNLNYMKGGNDHYNNDIFIKYYEKYSIKNLDKNESEKLNYTDCYDFKDSSLTEISKDDSFCSDDLGNDDNDINCLKESLNSFDNLESTEKKYEQILKDFNGKIPLLHKVLKPLPVKNRSNNFDICLYLLQKHGGDLNNEENICILRDREIVQHSAIYDTKNNCIKSNITNVTNIKLYHPKWYNKKKIIERLKEQSCYNPFTIFGSAPSLLDFDEVFDKDVYNHFVSKNSRKNHSLLRILAKQKVISNLNDKISDKEWPQVHSYLKKRWSRETNIELNWACDPLLYEELEWYLSTNNEYLNMTDKVADIDVCYCPTLDPSSYYAWNDSRVIYTNLCYNKSKDDGEESNNDSKNMYSTNKSLEFKKNDKQLSFRKRASGCEHLMFQQNVMKQKKLSKKKKKLLKKKKKMIKEKYKTMDIDVNFGNYGNDNNREDGKIIKSAEGFSYPYKNMSNYHENKTDYINDQYMNDFKNNKENNSFYYSNNIISKNKKSIYNHKNCEDNIVPIMAVNTSLYRNNMDNKYNCHNTAFDYIKNKDNTIKFFASPKKKKKKSFKKSINSDCFDFINSSMTNSDSMHPTNNNNENSSHNIGNNNNDNGNPDFNCNDTTEFNEFNDFSTYNNNKNNFHIFEFNDSIKCNNMKDAYNKDMMLNEDNLKKKHNQKNYEQTGYIEEMCGNKNRQNDCELLDINENNFEKNNMHYFKSNTYMYDINNNNASGMKNYIAKSNDNIVYKSNYNMNQGDISQSFYKNNGKNNNYGNDNNVKMTMFRNMQMGQNEYNMNYHKGNNNDNNRNGDNCNYRKGDNQMSFIPRNFDDKNDINTYYKVYNASDNNSNHNFHKNIYGNKNIYVKSDSRYVSNDYNKLKGNELSKNEHISNNIGHFEYKSSNKNFPDQNILNQKDNINGLKEKYINMCKEEKQLITSSDHNQFNFFESNYENYNNNNDDNNERSNKIMNEYFHSKNPENYIQMEKKNKKKKQSNDTGNSNNTMENHQNNNKHINKNLRNIIPETNILKLTQENIDKKNIIENEIKNSNTLLYKKKNNNNNAGISTSSFNSKRLSNSNISANENKKIRRYVNKMHHDSDNVSIEHSENDKQRNTSKEIAETPSSATSETSMSSAFKMATSVFKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXH9</accession>
    <name>V7PXH9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_00144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXH9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB63337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="496" mass="59125" checksum="45EA8C55FB2C8534" modified="2014-02-19" version="1">MKFAEKLKHLKVKSWDNKYVNYKFLKKIIKKKINPEIKALYDRIDKNDEQILEVCKLVNLDNTLLNQKDKKKKNEIENEEIDYTYLFFYVLQNYINMVKEHYESEYNYLYEKIDEIVFFLESDRVNLKDMESLKNKCLNIYNLFDILTNYLNINVLSVYKILKKKTKKERLSTSLDLYQKYCNNLHQISQEEHFNEKIKSTFLLIQKKIGDNCEKIDFLNFKIYLKSKIENLGQYRGTIFILCGILITLIINTIILLYLNINEININRILSILPIYRLIYVLNFFFLFIFGSFLFMQLYGVNFTYILDLNKKIVNEYYYLINYVIFLLFLTTVSLLIFLLDVLFNLNIFSNIILHVVILCILLVCTTIFPFNFYKYKENNFLFSSLSRVLMSGVFLVNSVNLLDNIMGDILTSLSKTFSDVQYIICFFLNGMDTTAPAKCPIIESYVNPIFVGLPFYLRFCQCLIRYNNERQTIHIYNMLKYVSGICIVICTSFNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXI4</accession>
    <name>V7PXI4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_00144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXI4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB63342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="446" mass="53061" checksum="9528F4C77C1BE028" modified="2014-02-19" version="1">MKFAEKLKHLKVKSWDNKYVNYKFLKKIIKKKINPEIKALYDRIDKNDEQILEVCKLVNLDNTLLNQKDKKKKNEIENEEIDYTYLFFYVLQNYINMVKEHYESEYNYLYEKIDEIVFFLESDRVNLKDMESLKNKCLNIYNLFDILTNYLNINVLSVYKILKKKTKKERLSTSLDLYQKYCNNLHQISQEEHFNEKIKSTFLLIQKKIGDNCEKIDFLNFKIYLKSKIENLGQYRGTIFILCGILITLIINTIILLYLNINEININRILSILPIYRLIYVLNFFFLFIFGSFLFMQLYGVNFTYILDLNKKIVNEYYYLINYVIFLLFLTTVSLLIFLLDVLFNLNIFSNIILHVVILCILLVCTTIFPFNFYKYKENNFLFSSLSRVLMSGVFLVNSVNLLDNIMGDILTSLSKTFSDVQYIICFFLNGMDTTAPAKCPSKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXJ7</accession>
    <name>V7PXJ7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_00518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXJ7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="9">
        <location>
            <begin position="385"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB62878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="463" mass="53353" checksum="E932DC8F8082536A" modified="2014-02-19" version="1">MTSVNQSRGASGAFVEFQVVILTNDENGFSSELNENTCKGLLKVSNRCMIYYIVKNIIEQKLKYITIVVNNKYYDDMVKCISEEFPDNYKFDDKKNKNSYCIDIEPYTTDSNDEIGSIQCLLQIRNKIKSDFIVVNTDIFGFVDFHSLANLFRGENALCALLLLEENDVNNNNNNNKKKKEIADEYLNLENNVWVCIDKNSKVVSISDAVSMKQDGKLKIPKINLLHHKKFILKTDLVDSHVYIFKNYVLDIIEKKKKFSSIKYDLIPYLVNIQNMGKVGEYYNKSEFKFNMYKTLINEYSAEQSQNENVGNEANSNGMANVNEHIENVVCYVQPKMNGFCQRINNIPNFFKANLLFCVARHEQLKDVVPPYFFFPYSDKIQSYKDCIIGSGFEHEENVILKKSVLGKNVKIKKNSNINRSILMDNIIINEGCQIQNSIICNNVVIEDNCKVSSQKITKNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PA28</accession>
    <name>V7PA28_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine cyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PA28"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270:SF1">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41426" checksum="78C6850DFDA7E35B" modified="2014-02-19" version="1">MCLRRSLKRVVILVIIICMLIAATVLLILHFVLNGNSNYPIDIGIYSYEIINKYNHIHDPIIGKQANVDSIIHQRYINNHPFTQGLLYIDGNTLIESSGLYAVSYLRKFKLNTGATERYYNLTNNYFAEGIALVVEPETYRKFIFVLTYKENTILVFDYNTFELYNTFEHDLNGYGLTSNLDPIHSIEDLKNGKFANYQKLWTTSGSEFLYELEIPNNFKKTNKINIINKKKVTCAGFTIKHINELEYHLQEKTIYANIFMTNLVIEIDISRGSCLKIINLSGLIDQNTNKQKTERNRESFLNGIAINPVNSKEALPNLLVTGKFWPNLFEIKLVKTNGMNPNSVLVEYFKTIRHNNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>V7PA50</accession>
    <name>V7PA50_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_05707</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PA50"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="246"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="526"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB56264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="674" mass="78810" checksum="FFF3C5CF7B810761" modified="2014-02-19" version="1">MIFKKVSIDSSLLKRLSKEGLVSIEVAKASDVKILNKDNVENSTNKNRDLKKKKNNNKLSKVTKKTITKKEKKTKKKNIKKNNNNDSDSDKASKSVKPNETFKTIEDDHKDRTKTKIEVKKKRKKVRGKKKNKVKIKINKDKNKSENSSGKKENDVEPQNYDKNMSKQSNEENNIKEVEQKKKKIFDIEQIIKNEENFKNIKEIKYKIHCSKWNKNNELNISHNIIKSLYDHNFYSPREIQSKTLQHSINEKKDIIVVSKTGTGKTLTFCLPILSNILQNKLKEFHTKNNKINNSEKKANKKTDKKTNKKTGQKFRCLVLVPTRELAVQILNHFNYVNKYINIYIITIIGGLNINKQLRLISKKPEIIICTPGRLKYFLQLEDKINYLYNMKNVRYFVCDEVDKMIETSFINDIHFISKHLYKCVDEKKKFIQTFLLSATLSLTVQLHNENLAKLLNYISIRKNKSYIIDLTNEKDHDQNKILTFNNNDINYNNSTFLPDHLTLNIIKCEKKIILHKLYYLLKLYILKDLPTNKENKIKKIIIFLNTIKLVKDVSTIFKYLFFESGLESSLPNKYKTNLSLSKKINIYSIHSKQKLKERIQSVSKFTESNNSSILFCTDVMSRGIDLNKCDLIIQLNCPISDITFIHRSGRTARNLKSGKKRRKISTQKTPSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PA58</accession>
    <name>V7PA58_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PA58"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="195" mass="23527" checksum="FFBAA5790E615BC3" modified="2014-02-19" version="1">MNDIISKDNQIKSKNFITIYTIRMYLNGFIIGYVFRKEIYKNFYMHKNDNIIFDIIKKNKFSPIYNNYKKSTYISKITLRYKTKNDLFKRLKAYNNNQNYQNYQNYQNYQNTSKTILFHKLPYLKRNFHIPNFFAVRLSFWTCISSTICWYLNKQIDNIAISSTLSGFIASSVNKTFFRESTKVFIPNWVGCIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PA87</accession>
    <name>V7PA87_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">YYC_05736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PA87"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB56304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="591" mass="71666" checksum="693C861EA64985F3" modified="2014-02-19" version="1">MHGRKANNYKEEYGKLEKVKELIPVVNDLIIKKKTSKYEKKYIQMSSTILRKCPYIQTLWNYRKEYFEFIKDEYLNRNEKIHNDPKGDIEEKKSEEFKNELKEMMENENSMIEDILVKFSKCNELWFHKLWIIKYCIKNDLINLEHLLNELEYCKKSLYIDDRNYHCWNYRSYIISCINIYKKKTNENLPTNMGSVEINEDDKNKHVEQNVNNFNVQTSNCELSKLLIERNFSNFSAWFLKYSLKEELININEELELIKNAIFTDPSDQSLWEYYRWFLFKKGKYEEEIFFITLENNSLYIFFQNIVKINTDKSKCYDSQNEEICGKWDRQFIINNSGNKNLESYIYIFKVNENINLSNFSYLKLSICYYKYNIHTPQNINYEENVLQDLLIGYDHLIPNEKNQYNIIYEINFENFSKNSHFKLLLNYSKENNKEDQTLCKNNCVKPYTNLYKYINDTNIRLNLAKNVNFHLLNFELEQINELLCLESDCKYALFTKYEILKKLERFDELFEVIDKLKEIDNIRIEYYNDKESELRIQQKVYDYYRSSKIEDNDEILDLSGLNIENIIYPSLIEAFYIQKINLSNNILFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBU4</accession>
    <name>V7PBU4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635811">
        <property type="protein sequence ID" value="ETB56889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PBU4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="2">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="364" mass="42476" checksum="79A6F962670B9BA0" modified="2014-02-19" version="1">MRTKKGCVRKVLDDSIKLSSIEIVSENTSDSYIYTAPGKYNSLAISLPILVLIVKNMNKYFSFRISIMDNKRCRRTFRISNFQTVTRISNKWCTMPMVLNEGWNILQINLSDYTEKAFKTKYVETIELQINASIRIRCIYFCDRIYKNEELKDEFKIFSKKKEKIVYIPPQNLIKTLKKNTIKNAVKEKISKKENEQECKDENNTSKPGEIKDTSLDSTKEEASIINVPQTMVEINSTENKDKEIESNFKREDDQNIQTNLEKENKTHDYMDMAEGLENYTDKVEEIDMIIKNDEDAHSLSKIIEPLDDEENNSTMDPNKTLLVEGNDNEADINNLTEIKNIEMDLNNVLYEDTNYDTYNNDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBV2</accession>
    <name>V7PBV2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_05686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PBV2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB56232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="185" mass="22345" checksum="C16D7AB91F38A482" modified="2014-02-19" version="1">MVLVPQKLIVHYNHCSIKNVGETFIDYINVQLFFLKNVLKCPFIYLVEETHPISNYKGFPYAFNTLEGNILYGEDIVNYMKNLYLFDSVNYEAYYGIVSELKAILIYYLWEDKEIYNNFTKKIYRDNFFYLYYIYIIRKLKNENLEKCKTFGLDNHNFVSTICEKYKNILYDNLIKNIMVFIFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PBW2</accession>
    <name>V7PBW2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PBW2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="52"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="164" mass="19254" checksum="7B4D99A2DBC161B3" modified="2014-02-19" version="1">MFPKNMKKKLYNLVLKRSYTRSGGLRKPQKVTNDPESINRKVYWCFEHKPVRRTVINLIFSHNELKNFSTLLRNTNASSLLIHELSLEGPYTGFLPSDEALNLLSTNSLNKLYKDDNKMSEFVLNHFTKGLWMYRDLYGSSYQPVSKRNLLKKLLPCNTIYIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PC62</accession>
    <name>V7PC62_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_05786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635825">
        <property type="protein sequence ID" value="ETB56357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PC62"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB56357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="683" mass="82050" checksum="DBCE1461369D3533" modified="2014-02-19" version="1">MFFLTNPFEKKKNNIIFRAKLEEKLNEYLCNGTIISRDNFFDDEKKKIKQGDISQIKITNEFINNCNTNLLINILKINKKLKVCYDVKYNVVYSLLLKSFEKRSNICINTKNKKCEPMVNVYKIKRKNISYFMNQYHIIKCIYSSEYGNIYYCKNVIDNKKYCIKLFYLRLCLKDNCPYYINNKVYLTNYFYKILSEIFFLNYLENNNIINIEQIFCDEKNEILFIIFPYIKHQSMYYKKKPKIYSIYNKKLVRLENKKFKIHLYSENFIKYIFLNIYNTINYLLQKNVAYLDLKPDNILLTHRNADTIESYEVSFTKKKKIEKLNKVLISSSSKEISNIEINLHTKFKEQIKESCTKDEYIKNAYANKMFLTTGKNKKTVISKNNICYYCSYANLKPEKLKKNKKIKYIYNVNLSKSFEYDKTVKRIFFTKNKLDTFFFAPHNTTTFIQTFIQQKNKHNKSQNNLYKKYEKRKKTNNALSPNKTYINKIKNLSIFKYNQKHSINFLKFYWLYFNIGKSCDINNDFLVYLDLYFFNKYYNKIGNMCTDVLYMTRNQYIELSTIKAHTDNIHEKGKTENMNDNDKNAYKEKIQNHDIIPTDDTEKQSCLSNNKINYNNSIKLIDFDACTFIIKSFNTYTRETDIFNSFESLFPDINKTIELSKKQAYNFGSVLYTFLFGIPPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PC64</accession>
    <name>V7PC64_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_04968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635808">
        <property type="protein sequence ID" value="ETB57137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PC64"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB57136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="356" mass="41859" checksum="40380914637CC689" modified="2014-02-19" version="1">MVIEKEYGMSTFGQNEKKDSVIKNLHLLNNENGNNFEIVYKLHSSIGGCLLICKNKFIKKHSYQNIFITLVYGKIKEKYNTHNEIKMYLKYIPNSNIMIPECENSQNFQMLKYEVISNSIMLNKQNLSLLKIYINAKNSKYIKPLLFYSLNTCIVGDNEYINVQKKFKSNFFYNFSEKKNQNYNLANENKMLLKNLHKYNKELKLHLFCFNVTFESHCNKLVSIFCQIPKHIKDTLNLFGATCLVKLIDSQVKNEKKIINIKSENVENLTIIEKEEIVKNKILQINKNINIEESNKFYDSMKDQNRLNEESEEFLKKIYGNNDVNKKGRKKPRRGILAKKINKLSTSDAPIYFTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PC88</accession>
    <name>V7PC88_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_05432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007732373" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="544"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB56590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1332" mass="160210" checksum="7A27D996B3CD4E85" modified="2014-02-19" version="1">MNNIFYIILFFILSSKIYHEMGSCFQLKPISLLNTNEYLLKIQRPKNIRSIITLENSFSSYRNSLKPLNTKKNEVYEYIEKYITNTSYPYNKSKNEIKNDLDKFISNFTSNINAWDEITIHDVNTKDITSLINILGTKYKKAYIDVGEKKKKLGDIYNLKEIKSLFLSLESISIENINANDFFKHLEVYTMLLTYCKDNYVSFSFIKNEIVNSMDKIIKYSQNYLHDEYICNKMKSEFINIYDLIKKIKKNDSIKINIINFLYILSNDAILNNNSIFYFLTEIFSSLNLLMKDSPHLVHFYEYIINPEFFFLCIFSLYTYNISKSRFYYFMLLIHNQINPTNKKEGDAEYDSNLNYNVYREYVINNIFEKEKIEYESIKNAIEYEHTTNIEKQNDTNTQDINSNEKKESIVNNKTNILVKGNENNLQFKELYNNLFVQLLLFYVFFYFSDYYFCIIFLLRFKHILKDKEQCDKNLQILNYMLFILLHNLYNIRDYFKVTIVLNLFKNNFSSFSDQHLAYAKKITNSVINNVTEDTSFHNTHKLLLEINEQIKNIENERNIVNTNDTSILFTKKDVRSNGNEKNKKKIDKCDNEHVQQENEDTFFLKHLKSQDINTSDLIIMREKFNSYLVHLLKNKEHDKIEKLEKRDNLYANNKTYSLFIKSFLYNHKYDKVYKVYKTMKLRKNIPIKYLNVKNLIESFKKCDIDKGDVLNELNLISKYYLNLYFSKDSYFVLTKTLLYKHMCDYLKKKCDMKLMIDIFNINELLKYFIKFKSFINIKKLYFLLLNHSYIKTYKTYLILIRFFNNLNYENEKVNENDDIKIEENVINKDEEIEKNKIENTMFEKNTIIYNDIINLRKNELFYYICKSKDLKNNIDLCHKIYDIAKKDKYEMSLFVLSNFITEYVLFDYPLLYNILENEYSNINNILNIFFESINLFFYKQNYRIALNISFLLLLYLNYYVTKYVKNDFKYSMFLKKNILNFFIGNNYGIIQINKDEIYSYIPNFILNIMSMCINHIKNSPNIKEIISSDMYYSYDFNKNIIDSINYKNIMSIFSLLKNNLILSNGNMEKDIFDKKMNNKRISMPNEEVIEKKRSYLYNDVIEKKYNEENLIGNENESYSNSFNNSNNVANLFVKLKYTVGTNKIDNDSLKDFLFTKLKNSVTNKNIDLLINILKDIFFTYKSIIYLNSKDFLNIYEILNGIYDNILSIITIIFFMENINNFTENEYPFNTSKQQLQEEENTNKININEFISMLKSENKQYFENILTQGFFIKYLKNYQNFIYMCIYYDLNKKKVKNIMRFLDMLRKCNTIPNTEILMDVFSLYFDKKMVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDZ7</accession>
    <name>V7PDZ7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_04482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635795">
        <property type="protein sequence ID" value="ETB57634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDZ7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB57634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="335" mass="40498" checksum="E4979600BAC5D2E8" modified="2014-02-19" version="1">MEIKTNNNNLEKETNFEINNINRIILDILCTEAIRKIKFILHVLKEILKKKTNILHVYITNNIDHLATEKKRKQIFNSLQDQIELCENENDYNNIKDKIQEYINSISETNEILCQNSPIDRNIKENRDKIIEDGHLLLKIFKKIKKLDFISVLNELSIFKNDENLLVNLNQNVYHKKQIINILKKQIEELIENTNNKKIRIYEKIEQVEKKKKIFFVKSMLYYIYKKECVQANVSNFNMDIKFKHDLTQTSKENMENELKTYYDINEYIKLFLNKRNDNLQNIHDSLVEYYEKEKIKKIKELEEIKKKVDISILIIQQKREIIVRKKDVKDWLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>V7PDZ9</accession>
    <name>V7PDZ9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 3 subunit G N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_05423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635815">
        <property type="protein sequence ID" value="ETB56578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PDZ9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eukaryotic translation initiation factor 3 subunit G N-terminal" evidence="2">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB56578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="228" mass="27069" checksum="ECF16F0DBF3D342E" modified="2014-02-19" version="1">MIQTEKKNWVDIDVDDDESLNDNENKKKWEDIDADDDLESNKKLSYFTNYENGVKVVTKYSENLKKQTVKVTKKIKEVIIKKRLNKEIENRLKLKNFNVDAFSSVIVEPTDVVNIEPPKNNLLDFLKDTEYDYLFAEQTDKTAKDLKNRFKMFKDEEAEEAKPDDANKAGAKRDMMYYRSHDTQNKECTIRVTNLSEDVNVIFKIKIIKQLYRKTEKQKRKKKHDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIB1</accession>
    <name>V7PIB1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Calcium-dependent protein kinase 3</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">YYC_03415</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase. In the mosquito midgut, regulates the gliding motility of the ookinete which is essential for the ookinete to invade the midgut epithelium. However, another study showed that while required for ookinete invasion of the midgut epithelium, is not required for ookinete gliding motility.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the centrin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIB1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000147">
        <property type="term" value="P:positive regulation of cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000739">
        <property type="entry name" value="CAMK/CDPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="112"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="25">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="25">
        <location>
            <begin position="482"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00057374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00068068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="ETB59159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="522" mass="60302" checksum="12E6506B4EC262B5" modified="2014-02-19" version="1">MNQLCVERSPNISTATAYIKGKPKKSIERIKKKKDSNKSIKSQHKFEGSKISNKNNELKDVKSKDPKNYESYLNKNTKHKDILLKSKRSDNFKFSRRGFILSFTGNLEDFYNLSEEPLGKGTYGCVYKATDKLLKIQRAVKVVSKKKLKNIPRFRQEIDIMKNLDHPNVIKLLETFEDEEQIYLIMDLCTGGELFDKIIKKGSFVEMYASFIMKQIFSVLNYLHIRNICHRDIKPENFLFYDKSTESLIKIIDFGLAAYFNDIDYEMKTKAGTPYYVAPQVLTGCYDYKCDLWSAGVLFYIILCGYPPFYGESDHEILSMVKKGKYNFKGKEWNNISDEAKDLIKRCLTIDSGKRINASEALKHPWFKKKKGSFNLDVKMDIHVLENFKNYALLLKLQKLAMTIIAQQSNDYDLQQLKAVFLYLDEDGKGNITKNQLKKGLENSGLKLPQNFDVLLDQIDSDGSGRIDYTEFLAAALDRKHLSKKLIYCAFRVFDVDNDGEITTAELAHVTFFVILFFTSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIB2</accession>
    <name>V7PIB2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIB2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="174" mass="20571" checksum="0289986CF6B3732C" modified="2014-02-19" version="1">MSIILRINMCELKPTNSNELQIEFVDEENISNNEKGGNKKKLKEILKRVYIGIYEDSKNILLLKNTGITHILIIRSSKENNIARIMFPHDFEYYIIDIKEDFDFTVYSHFKCLLDDILFENKNNKLFIHSYFNLNDILYLIIFYINITLNCNINDAYSYVKKLFSNLIIPIGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIB6</accession>
    <name>V7PIB6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIB6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB59164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="188" mass="22406" checksum="64BA5C7CB8E32603" modified="2014-02-19" version="1">MLTLLRLFCLYPHCYDKSVIKKILVCVLYNINTVDMNIYLSLINPNIYDDNIKGIVYLHDLIKECQFKKLWNCINNKSEGNNNYDYSFLQNYNNFTCNIRKYILNSITLSFEKISIKQISEYLNMENVEEIEKFLNENKWTVKKIKNKDGEEQTICINENIENIQNRKNISTYFNDDNVTSYINKLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIF1</accession>
    <name>V7PIF1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_03454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635767">
        <property type="protein sequence ID" value="ETB59204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIF1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="54"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB59204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="241" mass="28582" checksum="1D78CF9427685BBE" modified="2014-02-19" version="1">MCVNCNYMNNINVEIYFFYKGNDFSNDIKIVVNEMKQKFDKLLTASYSIKKIDTINASFQWAQSPEYIFLNIKFSHRWSSPGALKVKDEQIVSENNKFFFSAYSNDPNTVKKKYVVDIDLLHDIINSETKYNFASVGKVVITLKKKEKKIWNRLLLSKEKNPNLQVWWDMKEKYNDSVLEFLKEEEQKRKNEKTENGNEDENSEDENSEDELLYEQAEIDDNKNNNDKNNKIEKDMIDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PIG1</accession>
    <name>V7PIG1_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enhancer of rudimentary homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the E(R) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PIG1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2260.10">
        <property type="entry name" value="Enhancer of rudimentary"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035912">
        <property type="entry name" value="EHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000781">
        <property type="entry name" value="ERH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12373">
        <property type="entry name" value="ENHANCER OF RUDIMENTARY ERH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12373:SF0">
        <property type="entry name" value="ENHANCER OF RUDIMENTARY HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01133">
        <property type="entry name" value="ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143875">
        <property type="entry name" value="ERH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB58810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8656" checksum="0977E11711925330" modified="2014-02-19" version="1">MSAGYSDVVLLVQFSKKIESRTFVEYNSLKLALNGICQLYEQAIKENDPSVQRITYSMNDLFVYIDNIQKMTILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKF0</accession>
    <name>V7PKF0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKF0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30259" checksum="FC8EE5C985B05F38" modified="2014-02-19" version="1">MIDSNYDRINKINIMNMQNGNDIIKGLCFYIDNIKICDLLKKNIKNVRKANPIVERKNKLNLKKKTIDPEKKSDSIKKNPCNIKSLRIFNTNIDINAIILLSKILYDNNYSKLEHLAIDCINLENDSLKYMSLSLCNYNSLKSLSLQYCNLNNDAIKYIIDIVIYVNSSITTLNLSGNKFTEEGICSLFESFLLNNVLSNIDISYNMFNLSSPFIEMLSKIIINKTNISSISLIGNFLDNDNLSKINDAMTFNKSLSVLKLPNGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKF9</accession>
    <name>V7PKF9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_03581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKF9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB58803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28568" checksum="4F03987881F0FC9F" modified="2014-02-19" version="1">MNMQNGNDIIKGLCFYIDNIKICDLLKKNIKNVRKANPIVERKNKLNLKKKTIDPEKKSDSIKKNPCNIKSLRIFNTNIDINAIILLSKILYDNNYSKLEHLAIDCINLENDSLKYMSLSLCNYNSLKSLSLQYCNLNNDAIKYIIDIVIYVNSSITTLNLSGNKFTEEGICSLFESFLLNNVLSNIDISYNMFNLSSPFIEMLSKIIINKTNISSISLIGNFLDNDNLSKINDAMTFNKSLSVLKLPNGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKG4</accession>
    <name>V7PKG4_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_03281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKG4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB59929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="124" mass="14898" checksum="A91757F01860A694" modified="2014-02-19" version="1">MCAYIILIIYNVILLYLFINIYIVFLVFDKIDRGELKKEIIAHSKKVSLDLNDEQIKSIENKLNEFFSYMKWTNIRINLGKKKFKHKLKRLSLREKEGINEEFFTENMNKEGNYFVVSSKNYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKI1</accession>
    <name>V7PKI1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKI1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="151" mass="17241" checksum="C2AE227B057079A6" modified="2014-02-19" version="1">MFNYESIFINEDVVSEMTIDDVKNLKPYWNVQIANFKDSINEPVFTLLQMAILLNKKKIVGYLLARKSLDINVLSKHNQTALMIACEKKVPLDWIEAILKKGGDLGINVKDDFNETALDKCTFNSKAYQMLLKYGAIESKNSSEENNIMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKI7</accession>
    <name>V7PKI7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKI7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB59490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="125" mass="14204" checksum="184A9DE1E12E3325" modified="2014-02-19" version="1">MTIDDVKNLKPYWNVQIANFKDSINEPVFTLLQMAILLNKKKIVGYLLARKSLDINVLSKHNQTALMIACEKKVPLDWIEAILKKGGDLGINVKDDFNETALDKCTFNSKAYQMLLKYGAIESVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKJ0</accession>
    <name>V7PKJ0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_03610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635769">
        <property type="protein sequence ID" value="ETB58838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="805"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB58838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1345" mass="159754" checksum="F7658BAF01974AA2" modified="2014-02-19" version="1">MTIGLFRFQMDNINEEIDENMSPLEKAMLYGNSNLKCRKILFIKDIIKLLNNIDYTDFQRDIYPLIVKLSDESSEIKYEICNKIGDLCAYILQNNNDGCSDVISLLFPIVEKFIINYENNKNILRYILKSLLILSTHVNIKTRKKQIFPFLIYLICNDAYKQIGFILLIKMCYIFDRDNIVIYKVLIPFIEKHCISNNIECKILISSYFFNICKMLDESNFIKNQIFIFNKLCNDEYDTIKIINIFNCTHLSSIYSKNLFFNFFLPIFNNFLKNNNLYVFYYSLINLLLFLCIFEDINIIHPFYIRKIIFFFNNLFSSHLFTLNYLNEMAKKKTNYIFLDNTDGVYDDSNSAKIWNKDEKRDDTPSYPLNETDMVTDFQNSKSEKNNEHTIQNTISNELKYYDNYLNEDMCKEKQNNLVEIIEKDPTRQICNDEQNLTTGCNIISPINGKGLWVEDNKNPHKNSPMQELPQNKSDKNINNESDERDKLGIGNISCEIESTEESKNCNFSSESEILNKRKMEKVLFSSEISELECSSVQSLSNEIIYDENVCIFINNKLINDLIIKNHHFCSNISQFFKTHGNDYYKNGNCDKYFGRKIINLMEKNSDDLILENKINGETIESEEFEKDEENYFINLNEKDIKYIDNIFNHDDNIDILQIKGCYYSELEIIKNDIIYGKMLLRQKRNMYKINNNNKCDSSDNITYDIDYEDIYAIEGVDTDSLKKLFLFDTPNNVIVSYNINAVYIITLHIPGLILILKEYFFRFFSHVFFFICTYPYYFVRKTIASLFYDILSNLMESPFFKINTDKLYEDRINMKKQKKNLKKNKKIEETAKKKLKEECSDDIKKKENNYDGEDSTEQSNLYTYKENNIKHQDINHIYKKEPPEIVQTFNNDYATYNNMKRIQNNSFLTSDKSCENTEDFINSCIMEKHEDVLEKEENKLCDDTLDMIYSNNSNTNGSHYSLDQDDTKNITTDTIDQIKEDKNDIQLKRVKKNAQGYRKKWSYDKMIKKVQNKINNNLYANDFFINEENENFFFYINFLGKYEMIYIKYIQKFKKYYSDNSPLHFFHFFIYYFLNDSNVLVKKAILKNYDKIIEFFPNNIQKIFIKYLSDVVNFKTLNYSLRKKVSKIVFKILSKINDAKIVRNCLFPIFMRLCKDEAAIIRTYTSNYFYLFIEKGCPRIYNFFKNGGEILPLEDYKKDIILTNLENDELRSFHFISGEEIYILKTVITTFYKSDRFYDRQVFIKICDGIINECPKNLFLLYFLKPFLNLSDDKVHVVRMTWENCVVSQIQKRGYILSIPSILEKLNNFHEENNINCIGTNIDYDVNKYNSISIETFDVDDLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PKK2</accession>
    <name>V7PKK2_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PKK2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB59505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="626" mass="73329" checksum="47C16C0865A9AA3C" modified="2014-02-19" version="1">MKNGYGNFIWNDSKSTYEGNWVNNYMQGNGKYKNKNYIFDGNFHMNKFINFNGEWIDIIEIEKNNSKNNRVNKQIILNNNIDLIILPFDFFKVNLKKIANTIKYNFNKIPFIIRSKNFMDKHKQNIDLSKLIFLSYYLNTLEIKNYLDDDQLTFDNLGKNILKNQNINFDQDYNNYNVSDFDETESELNIKSDTPCSHTSDQGSESTTSNNTDKISSNDRSSELEDSITASNSNDSTTSYGSRMSIFSNIPEICSKQNSLNSIKSDNENINSPNRSTLNNLIENKTESIESDGSELKEYIKNRNSSSIEMDKKDKDAFSKSGSIRENDLDNNENDNNLKESNCNSKNREYYNLKMSNDSTYVDIEKKRKNEINKLINKYINIYNNCESDSSEYSILSSGKEIDKSCKNDTNNEDKTEKIENEENENKNEKDKEENSNKIININNKENNYDDINKIVKNDILKIYISIKFLKKLRKCNLSCTYNINKKIKNSLILNYPFIFNLNYGKNKNEMVLDHLFIKNVTIPKFWNLSNYFGNSMDKISKDIFTPLYFDFRNENKNIFNFSQINKNNKVNLENDCEETDSNLNFFMVTDLLVDDTNDINYLKSLLIDKFKDFLYVNNLFFIIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMJ6</accession>
    <name>V7PMJ6_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMJ6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="301" mass="35641" checksum="7EFA276A277F6BC2" modified="2014-02-19" version="1">MNNRNRILYDQNFMTCSGEWLNNISHGFGCSYKKKKIYFGCYKYGLMNGVGIVKKNKSLNLCLFKSNEKKVGIKISKNMEINICLYKDNKIYFKNELAKYFPYYKDNNISQNIQTEIFYKILNIDKSAIDNEILYNEDCKKNKATSLICEEDITKLARNRNDNFNLKHFLEIKSKKFKNLKKDDCNVNKSNSFCTPYYNYCYSLPNQKINQKINNYSNSLYENPLINSNNTNPSKFPNKFYRNSVPTTDYINKSENDVLPFEFDRFDKFDDKIDKPNTLGEVGMEYEKNKRVKKKKKKIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMK1</accession>
    <name>V7PMK1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_02408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMK1"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB60017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="749" mass="84296" checksum="C2D9926B3B663AA8" modified="2014-02-19" version="1">MFVHMNLSQTNSRNVSETRMLGINRNNGNETTRLSITSEIQNNNESAPSDVSNYINEREDDNASENAGENVSENAVENAVENAAENVPENASENVSDNVSDNASENESINASDNVSINISDNEYNYNYNRNVEDEVAELISNSATEYIRLLEGDTYSIYDQPSESNLRGSRSSTPINQKSNNNDNGFSELSRILDGDYSYNHETDRFEYTHSPENNDIELTPISSLTLTGTQYDDYDNAVFADKYLLDGGGSITGSVDSDEYDYEREYEMLEARRNLNTNRIPISDIYRSGRFTLQTDSNEDISFNFSENYDGDIFFYNDREYAIGGEGSRINQNNSNVRNYGSINYTYGYDDDDYDYEFGNFEFTYSRPSYVSFRGDGMISFDSSLDYDNDELNESDNLEADPFSNYQTNYRSSMNLRQPPNEEFTFGDTPPSTFSLTRPALNLTPLNNAPSNNAPSNNAPSNNAPLNSTPLYSTPLYSTPLYSTPLNSGSLNRGSSTNAPLNSTPLNSTILNSGSLNSGSLNNPVFDDDDDDIEILNEVAACEDIFDEIDLGDGPMDNINLGRLIFNDTTINGTSFNDSMFSRSSLGDYSFGNLRPINRLFDEDVNSDNIRNVNMNRYDSMNLDNDNIGSDSELQPLLYNKRDSYESDNESNESEYFDALSNFEYNSDEDYSGSLGYFESKNNSEPIASCSNSTTAESYNENNDNNTSRVKEKCEEPLNSRVREESKFSYLYDDDEDDDFGILHFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMK3</accession>
    <name>V7PMK3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMK3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000502">
        <property type="entry name" value="Actin-Related Proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32043" checksum="096CE6220D1B6D43" modified="2014-02-19" version="1">MLKDIMNEYGNQLYSNQPIIIDNGSGYIKSGFAGDDAPNLVFPSYVGRPKYKRVMAGAVEGNLFVGNKAEEYRGLLKVTYPINHGIIENWNDMENIWIHVYNSLKINSEEHPVLLTEAPLNPQKNKEKIAEVFFESFNAPALFISIQAILSLYSCGKTNGTVLDCGDGVCHCVSIYEGYSITNTITRSDIAGRDITTYLGYLLRKNGHLFNTSAEMEVVKSMKENCCYVSFNMSKEKNTSEKSLTTLPYILPDGSQILIGSERYRAPEVLFNPSILGLEYLGWIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMM3</accession>
    <name>V7PMM3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMM3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="158" mass="18754" checksum="02AEB750E1947B26" modified="2014-02-19" version="1">MDEKIFFLQTYENIHEGTLPSPLIKHSDECKRLNNKRKKKNEHLDNSIVSKKEIRKSDLISITHNTNNSDDKNGDTNQYICINRNKFNGKCYHKKIPIINDVHMNFTIAESLIYILNFYLQKNIINLNLYNRMLYSFQLVMNKKIKNMIIFSNSILLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMM7</accession>
    <name>V7PMM7_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_02539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMM7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="86"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB60205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="308" mass="36221" checksum="4B92B27F44DE9506" modified="2014-02-19" version="1">MDLLDNLIKKKKEEIKEIKGNKRWLKQADLENHKKKELNKFYENEYKKKKTEEYERLKKLNDELDSKHKKASVDIENEDENTGIALSNKQIIIFLRQLKEPIRLFGETDLQRYNRLKELKINKNELKGNEQNVFGDVLRGRLKENAIELIEDNLEDKIEDTKNSKSVEKINSSTNGEANNEKGNIDKEKVIFNWIKNTMKEWNEEIESNIDDKKKIKQATYLQTHKDLKPLEKKLKQKTLDHDILEKIYNIVSHCEQKNFKAAHDAYMLLAIGNAAWPMGVTMVGIHERAGRSKIFASEVRILLVYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMN8</accession>
    <name>V7PMN8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204:SF0">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1312" mass="151866" checksum="9D6F3E8DD39353E4" modified="2014-02-19" version="1">MEEENIKIKVKSIDNQECEFCVKKNTTAEELKNMISEKKNVDVNDIRLIYQGQCLSNTKTIAEYNIQNDHIIHVVIRKKENINNSTYEKNNKFKNIDHDSNNNNNNNYASSTTPINDPLQYGFASSINFNTTDSNSNNNNNNNSNNNNNSNSSNNNSRPFGNTNIPTANIGGATPLYFTHMRLTRNDNLENDLMSQTNMCSLLNDIMSQVNINPNFIYGAAASAVNSVGSGENFFTANLRPNDANININEFRANKEKDQNCANVGNKQKEMDKDEIEKENENVSSEINCNDVKTGGEKGASNDNNDNNDDNGSGNNNDANGNGNNKHSREGRNKGKRNNSSSNSSSSENSSYEYNKNKKESDEEKKKKLKKKLKKKYMEKIRNKYSENINDIYSSSYSSDYESSYSEISDRKERELDDEKKKRHKNKILEKLRKKKEKKKKKYYYSTNSSSDYDKKNEKKKKKLRNKGKFMFDPNLLYNPNYMRNIYRGMCNPVQYNTPYITDINKGNYLRQNTKFNHIFNNNNNNSSSSVLRNVPYPYMNENDINKSMFYYDQKYGNISENENYINFKEDIPYEYENMKRFVNKKIYKREELNNNGKKRMINMNKNISDANNNNNNEVLFGSNFCNKTENRNINDAQNFIKNSNDGFTGGMLSGIAAQNSNNTATTTNNSGNNGNNGNNNGNGGNNNRSSYANIIPFSDIEVVRNNSIGSNSRSALSQEEEELSENNLIDEQMRSIQMASNNRRHLRSTSKLLNDENDFEYKNIELNIPWRIMDQLLVLLEEETGYKRPNLSSYINSYYNTNSIYVFFNLFVHINNIINSIIIQFNHSNFLNNDISMSSFSRISIILSLASVILSRLSNFFFVFYDNFYYNNYGRSYRYSEPINHEHLRELRNLYYSTNRNYNIRNSNISNLNYDQNNHFNNYRTNPNKTNLQQEFEDYYKNYLNGIDIDVNNNVLLRRDHPNFKTKNFDDNINNYKFKNEHKLSNNFIDSKKNKYNNNKSTDLKSRLKTDRDWNTNNPFSTLQNYNKNHNPLLYISKTKKKKNKKNAEKQKKNDKDISKNPSICSSKNSHNDSSKLGNNSSSQFGNNNNEPEIKNFPEPNVADSTTQNTKDKGNFMMDIFKNILKNESEEKTTKNNINDKNCLKINEKTNNTVPNTALVCYDNNMDDMYGTSDEEKEQTNKNINNEYKITEQKDSTNNPLSFEQNENIQKNDGKSNDGKSNDGKLNDEKHNSSNVDTQKNDKAVVNNLPIPNINFANILNDVQNQLATHKAPEAPHRDKVFHFVPISSQFRLHLAYISFPSHFSPFFQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>V7PMN9</accession>
    <name>V7PMN9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin fusion degradation protein UFD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_03030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635766">
        <property type="protein sequence ID" value="ETB59588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PMN9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB59588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27567" checksum="679B6AE4917FA568" modified="2014-02-19" version="1">MENGNKIILPQTALNALARRHISWPMLFEVSNPYTEKRTHSGVLEFISDEGTCHMPYWMMQQLCLKEGDIVRVTSISLPKGTFVKLKPCSKDFMELSNHRTVLETALRNYATLTIGDNIVIHYLGKTYEIKIVDLKPAFACTIIETDVEVEFEEPFEKVQYVEEIIPVEESKFKGKGQRTDGKACKNVKTEKVRQKIIENPEPWKEKLVGGVRTKCAEYEDLLKKGRIPGIIGKFIERKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PN07</accession>
    <name>V7PN07_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein light chain Tctex-type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PN07"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21455">
        <property type="entry name" value="DLC-like_DYNLT1_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9365" checksum="2090AE077FD31252" modified="2014-02-19" version="1">MYYNEEKTKIWVSQILDTTLKELSKLNKPFKYVATCTLMEKNGSPLTASNICLWDENSDGMCSVQMGNETLDCILCIYAIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PP06</accession>
    <name>V7PP06_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PP06"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1157" mass="125559" checksum="821FFBD1742911F0" modified="2014-02-19" version="1">MPKDMCMIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSVPTGGQSGPTDGQGGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>V7PP07</accession>
    <name>V7PP07_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26S protease regulatory subunit 7, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_01260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PP07"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="195"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB61351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="420" mass="46804" checksum="0338F70DDF0EC7BE" modified="2014-02-19" version="1">MEEEPATQSKPLDDEDINILKSYGSGPYSKSIKKVETDITGLVTNINKLCGVRESDTGLCLPNQWDLQLDKQMLNEEQPLQVARCTKIINSDTDQTKYIINVKQIAKFVVGLGEKVAPSDIEEGMRVGVDRTKYKIQILLPPKIDPSVTMMTVEEKPDITYNDIGGCKEQLEKLREVVEMPLLQPERFVTLGIDPPKGVLLYGPPGTGKTLTARAIANRTDACFICVIGSELVQKYVGEGARLVRELFQMAKSKKACILFIDEVDAIGGSRGDESAHGDHEVQRTMLEIVNQLDGFDNRGNIKVIMATNRPDTLDSALVRPGRIDRKIEFSLPDLEGRTHIFKIHANTMNMSRDVRFELLARLCPNSTGSDIRSVCTEAGMFAIRARRKTITEKDLLLAINKVIHGCKQFSATGKYMVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PP10</accession>
    <name>V7PP10_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PP10"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1150" mass="124946" checksum="6AF6E8862600C2F7" modified="2014-02-19" version="1">MPKDMCMIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSVPTGGQSGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>V7PP15</accession>
    <name>V7PP15_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PP15"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006477">
        <property type="entry name" value="Yir_bir_cir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06022">
        <property type="entry name" value="Cir_Bir_Yir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB60517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1143" mass="124319" checksum="B197511B04F3CB02" modified="2014-02-19" version="1">MPKDMCMIFKNANNLFNNEKIDLATINLKDGPYIRYCPYHRSSGKYECKNIYDGLNALCMHLFTELYKIPENTMKFKSNNRQYVGYIMMWLCYRLLQVKDYNDSTLLQFYENYLTNAFINYEHSERIHKNRYLKDSNIEYMSRLYNLFNEICNITLKYSKNPSDIDQIIVGSKKIYNMHKDLYNDLYECDSYVYLLNTLKTEYQKLRRNIIKNKRAAFISGKPFATPRDLMATRKLEKKVVTGFNCDECIRVNSNVKKKSHSPAEPLPKGPPQASRSEHKIPSPQAKTPEKSKDNKPETPLPPLPPRPEARRAPQPPQPPQPPPRPPHPPPQPPPRPAPQPVSQPVSKPVSKPVSHTSPPSQDNTESQKTKTGGSNHKIEPVPNIGSVPKIEPNALDNIKRNTGGPSVDKGGPRVDKGGSRVDNRIPSGDKGSPTSRNGSPGGISSDKGSGNGTEKPPSITSNKTDTSGSKRIIPDITKNNEDPKGGEQKSLGSDIGNKKSLLTNPNDLSDSNKHLSTPGTNQGDSNDGLVSGPKGSNVGGGDKDNRSLNTGSGQNGQDGQNRQDGQNRQDGRSGQDKSGDGPIGDQKSQEGSGGSGSSTEPSNDVQGGQGGSKDGHRSQEGSRGPGSETGPVIDLQRGQDGPKTDQDGPKGGQSVPTGGQSGPTDGQGGPTDGQGGSEGSKNLGGGPSSEPGKLGNEPDGSGSDKDPSDKDPSDKGPSDNGPETKESQNTSEKPLENGSFSLNIIFNGMEKINNTFKFYETYKEKITNISNDIHNVYNTTLDNIKTGFDKSINYFSEIIENINIDSKKVENSDNSGDKKPGSDDKKPGPDGTGDKSPTSDDPPTPQGGPNQEGPNQEGPNQGGPNQGGPTQGGPTQGNTPQQDLHQTNQHQGSLPKEGSHQGSSPKEGPPKEGPPKEDPPKKDPLQKDSLQKDSLQKDSLQTSPPESSNELTKTQKLSQGPSENNHREPQQPVPVSVPASVPAPVPVPVIKPRNPVAEIKGNGTTGIDINVLKKYKPIGISILVLLIPITLLIVYKYFSSGWKKKLKRKQNMKKVINLIGVNKTTKTVINSINGNKHVEIIINSSTPKKETKKFKKSINSVYKEKSPLLNIYKLVRADPAPFINLFFLLIFFVYKRKKDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PP23</accession>
    <name>V7PP23_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_02323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="551"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB60705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1308" mass="151617" checksum="846B50B350D3E37A" modified="2014-02-19" version="1">METRRSLRVKKQDSEEKGSKKKSTEIANKGKEKKQNESKPNEKKPNEKKQNESKPNESKPINSGTNVNRKKVQENESVKNKNVTKPRIGLRKQASNSDIINSSEYAEKEKVSELKNENKIVEKPSKRNKSKDEHKEAGNAKAGKKMEEKAGKKMEANQTAINRGNINRGSVDRGSVNRGSVDRASVDRASVDRASVDRGSVDRGNINRSIKRRLSQLLDRLKKEKLFQCLNDISDYSEIFIDNKEKKENETDVEIVKCIDTSLTKKINVDIIHSKLHYEMYKNENEFNNDILLLFDNSIDVIKSEKKKKKKKKLYNIRQNAFKNYISEFHKLLTSTRGTKEAKQILSSFNEYCEKDELYFSNMFENDEKIKENTSVGSEASGVNTEVKDVCTNLNASDIVKIKEKDDIDSTKDLSNKKRSSFFRIKLKLDNIKIEELNSIETDNTQSTHLHLKEDEPTIADKADKTDKADKAEKVDKIEKADKTDKVEKVDKTDKTDKTDKTDKIEKADKTDKVEKADNIEEECGNKNKRINQWENILKNNILKNLKCDSNSVYFTIPVLDDKNINEEIKKEYKIKIKKPMDYTTVSNNLLNGIYNHPNEIYNDIKLIYKNCLFFNPDISQNQYIINAAKNSDYKFENLWNKWKDKIYDNYYDVSNKNVNINNYIDYFKKKKIKNKKYTNIYSIWINYLINNKINITEFCKIRNIDIHELKKKTKSLASVEKVNLAESGLAESGLAESGLAESGLVESGLAESGLVESGLVESGLVESGLMESGLLFSIFKEEYKKIYKKNIPSRFLENKEERNYECIDNCESEKKKKKIFLKNKLKERDNFHDENKKEKDNFHDENKKEKDNFYDENKKEKDNFYDENKKERYPKILKNWKKKYNNIIYFYENIFDSYLENKESYMIKCENNTFLSNCFYFQNVLDNLDDFIYIPEMCGKTNIQNGENMTKNGENMTKNGENMTKNGENIAKNDENIAKNVHVNDVSDAKLVDSSAQLNVCENVVNINETRERNKREFENHSSISINLKRKKSEDIHIPICREFQESSDSTDTGKVEKVAESADVAESVEVADVDSTTPSPVLSLTTPSAAPSLTAPSAAPSLTTPPALFNINNKNFYNFHGLFDKMSNYNKETFLKKEKTILINLNLNYSTIENSSYSHINNTYFYNYNFDSNFFFIIKSGFKLNIYIKIKRTNIYINNENYVEHLKIYLINKCKQNKKIKLYISNNSPAKNNNNFVSFLEKAFNDLHTQPFPNNSIRIHDSVNKLSGLISQIQMYIKKIDALLRIDNNKESNITIINILKKKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>V7PP52</accession>
    <name>V7PP52_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_02455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635763">
        <property type="protein sequence ID" value="ETB60083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PP52"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB60083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="311" mass="37339" checksum="4153E920C0F8F12F" modified="2014-02-19" version="1">MVKLHDLNTDSYDAQNDCTSLYIGNIFSEIKDEIKNTVIGGNLQNGNYIKDNYKELYSINQNNTDNNENKNGKYNNDLMIDGSNKFVSEYPKINIQEYVNFISNKKNEYKKKKKEYVIKYINYRKLKNFHYKDMEYVFKKYSEFLCLEEKCLLCDNYLSFSYLYLNIYLKSKNNYNENVHKYKKSNNNLLTFCECLESIEYSVQYTSGKKDNCYIDMIHLFKENAYFSLDIHKNIIIKEFIKNVKFTEIYKYNSLSENYYNTFSIKKKNNMDTKYINVCQYIEKPQLTIDHVKALNTHVEIFTPLFVRILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQR5</accession>
    <name>V7PQR5_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_02014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQR5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="5">
        <location>
            <begin position="132"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB61077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="191" mass="22480" checksum="3316F2DB161B62E3" modified="2014-02-19" version="1">MEDPVTRFYKCRKTCCEMLEDRGYIITAREKLENFAAFKELFEENEKLRSRMTIITSHKNDANNKIIVYFVDEVKKTGVKPLRELTEKMDEKSIQRAILVTQNTLTPFAKDAIKEAAPRHIIENFLDTELLVNITKHELVPKHIPLTSDEKRNLLQRYKIKENKLPRIQDVDPVCRYFGLSKGQVQKNNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQR8</accession>
    <name>V7PQR8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_02294</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="984"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1237"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1270"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="492"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="757"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="841"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="903"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="776"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="903"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB60673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1318" mass="151775" checksum="5361EAC4DC875F3F" modified="2014-02-19" version="1">MFFRKIGEFISKIKHYSLNTFSNCLYKYAGFVYDRPYTIIFFSLLGCGLLSTGFYYKENEKDVFKLYSIANAYTYDNGKMINDFFHRNRNAIILVESNFNLLQEHILTELKKFEDNIFDIQVDCSEILECKIDDNIDVEQTEVAKKVFDKFNKNIDPNANYDWKPSLSSLNLKFSLNNLLPFKKKKKNNTDAGSGSDAGSGSDAGTDADADTDADTNDDDYDDDDDDDEDDEEDEEENNINEDVEYTDLRTKLKNGIDFLYDKIGILKKLFTSHKGKKKIIIPQEEKVAPTFDEFENDVFYPPYYIPPLLVKNDRCILKNVFKDKKLDVNLRTASESVKKEIKFKLNDLCQKKYGQCEKSSIFLYYENGNAKIGDPIKVDNLNFYVNRKSYKGMVLKSILGNPKYTQNGSNYVINYTNSLVTILNLHNSHTYEPYVLAFEKKLIDYVRNYNINHVINNDEETNDGNPGYVRFHVFAERSFEDEVDRISKLDKLTMLLFLIGIFFIFIYVLFNNVTSVLYRSKPLCAIVGIFCGFLGYLAGSGFLFFIGVKAVPPAETVPFLVIGVCVDDVFVIINSYSLLFMIKDDRKRIQMCLRDSAVAITVTTLTNVIAFLISAVSPFYAIYSFSLFTTSALFFSYILVITILVSILCIEARLEKEKKNIFSPIISLVSSCFCKDSRNKINNSVSNNNELSLDILTEEEQEKACAEYESLSIYQWIHNLYLFEESINNKKNKPSSKSKNKDDQCTIVDVAPGGRDLKGCKQTSKHRGNYKDTSKCITNSDNNSKKNTQGSTSKVYPSNPNQNKQKPEHDKSNIYSHYNIKGDINIRDNNINASVGDGHIESSGRTIEDDNTKINNNYPSQNDLEKDLRSIEVNSSSSVLQISNDISSSCLNNSNATQNFKDDENDCSKSGHNKDVYNNNEEGNRNKTKDCENKKIYMLSSHDNVLFYKYIYKEPKGNIGKCFRKLIKNYYIPFLSSRIGKTIVYLLFTFIIILSIYGCTFIKKGIRYVKAFPSDSYIRMFIEQRAIHFPNLGDVIEVYYFDKNFINKYRKLRKQYFNDDISNSYLSFSFSNNVDEDEEEEEEPLDVEPANTNIKWEKTAIHEKLKQVHEKLDKQDFIAGISNGFNFFVNNNSKQLENEDPEVFYNTFVNWVKYDYTGNMFKDDFIFLNKKLVAWRFKYVQKNTDDSEYSSLWLKKCNEIAKIEDENIQLLCFHISSIFYETDEIIMDITLKTMGITIFTILFVTAYIVEGFSSCFIIALIILLIDLSIFGFMCLCGITVNIISMVILVLSIGFSIDHTSHIVQAFTHSVGRTRNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQS2</accession>
    <name>V7PQS2_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_01720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQS2"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="83"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB61956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23821" checksum="BB55E2D542185428" modified="2014-02-19" version="1">MEHLKNLITGALAGVVVDAILYPIDNIKTNIQAKNQLYSIFEAKKLYNGIIPTLIGTIPASAFFYCFYEMSKKYISENNPNISKSALYIASTSIAELTACIVRLPFEIIKQKMQVSSEASVKNIINGVLKMQGAQSFLLRSYLVIIIREIPFDCIQYFIWETLKEKGQKYFREFYEKHPVIMSSLSGGIAGATAGFLTTPIDVIKSKHIIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQV0</accession>
    <name>V7PQV0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_02324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQV0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="8">
        <location>
            <begin position="810"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB60713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="993" mass="115428" checksum="D60B7C2619DEB9AA" modified="2014-02-19" version="1">MKCGNVNVRNVLEFNLKKNIKEKTKLTDQEIVIIYKRFHSISPNGKLDYKQFEKSLGILGTIKNAYLYKCIFKAFDLNNDGYIDIFEFCVAINIMLKGNKRDKLKLSYRIIQSGSSVKLENLQGEKHSKGDKNLQDEKHLQGEKHSKGDKNLQGEEHSKDDQILKDDKNYLEYINYDDFERIILSIKDIKKQLLGEDDEIVISHVKYTFKSLSILCDDGKDLPENGDEKNGDVKSSNNNTFKKDDIVPSSSEKKLYLNNISTKYNSISQKKQTKDDENELFESGLNNKSGKKILRKIDQIKLDKKINKRCDNIGNDFKKLENQISQNDERTTNIYYDVYKEPEIKNKKNVPNLDLAHIEQEYESKSYMYSTVEKKMNKNGSMNKSGSMNKSGSMNKSGSMNKSGSVDNTEFFDLKLQIFEFEKKEKNKKYIDTWNLYINKYKEYIKRVEEVETGENANGNRDGNASGHGNGCVNGSFSDNLVESNNIEKYYDKCNDIDSIDSDNNSNIYEKDVEGESVESSVSTYTKMSDKINGDIIKLIENQENESNDYISHGSNKKEENSSGTFLFEKYIEYHKFVNETEDIKTLINETYKNSQQLELSSNSQHFLINKNLSKEKLLYHIRIILLNVEDCLKSDKDNENYDKIFLIFFYIFIYNNTHEENTKIESKQVCIRDKHLKKYKSVLLIVSIIRYFLHTITISQKYYCSSYDSIDEYNNNNNNNNNDNDKNNNDNNNDKNNDKNNDKNNDKNNDKNNISKSNHEINIILNQTNDVLGKYAKGKFQNKKIYINKSNYYNSSKKRKLSVSIRHKKKKKTSKLFAVYFGHERWDLVMNMMIGIRICAIKKFNIDNILNYYKHTDVIQLSTSRPNEKVLFKNYSPIIFKNIRKIFGIKSKEYITSVGPEQVISNMVLGNLSTLSELLSEGKSGSLFYFTSNGKYIIKTVNKGIHKLSKKLLPRYYKYIQKNPDSLLTRLYGIHSIKYLNSSSSKGNRMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQV1</accession>
    <name>V7PQV1_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1355"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1516"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1582"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1639"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1798"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1834"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="842"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="984"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1085"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1243"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1359"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1381"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1413"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1463"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1516"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1593"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1835"/>
            <end position="1847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="1993" mass="231693" checksum="6D20854316D23535" modified="2014-02-19" version="1">MTDSMNLRDSTKSHELFIGSNITENVYENEINAMKEITSSNDVGMGIEIKKTMVNDEGEVKKKHTKKKIDIMSLLKKEKKIYKMEKGSISDIYDSYLLSNPEHVDHQKYYLSFSELNKQNSSDKNANTNPKHSDKRNSKNVKNGKKKMSINKKKSKDDNNNNNDNVKSKKNKKKKKSLNYIGNSNNVEEETKAQNNMDKNLNFEPHEDLKREIEKIKADIDKIKKKGNVKRIYDDLKYILLFQNEIIDILIEDIRKNKLKTKYEYLEDSTVKDDINKVILNQITFDLLKFKYINTKLKELILCVYDTKKFNNLIKEIIYNKINEMKRIGDQDGELTFAKTMLSFLYKQLKYSLEDEVQSYYTNIKNLNDDIHNIKKNMMNLIFNSIDNMTTIPDPEKVYNVLGNEQIEKKKEYEYKAAQKKQLICPPYYRDLNDFFYLYDSIYTDEKINSVKATIISQYMNKFKNYCVVDKINKRVEKDALNDDATPHRNTSNKNSEINLASKVSNTPQLCKSSHEMKFQSYPANLPHQNVYISSPNNLANNLIDMSIHDNVILNNKENNHSFLNCNNDTNTSSMQFGILPNIKPLNGYNIDEIKNGYINMNTQNINKTYNNYRLTHNLNIGNRNMHNNIPINNYKNNNAMMPLSFRNNPECNLFCNGDTRISSEQINCSNFIDSCNNIQNEIYNNNILNKCLDNNYSNKIAIRRVENLYYDPDNMQIIANNNFIPAKISVDSNHSKNINNSQHGSNIENVNNRIHIHDNNNDKNTNVSNNIHLKNDETKNIDINVDNANTYTGFEILSDKEDFKKLETFLNDKWGSFKLFEKWLKDCSKWQWIDLKLQREYINNNIELEKLKEEKKKYLEKCINNKIKELWCGRVKGLMNVKLCNMEKKIANEFSLNNIIKNNIHEVTLDYERSAMCYQDLYAQLYVIGLNSKKIEMIKKINEFKNNIDGVANSQENESDAKKKKDSSKKKGYVHSLIYSFNKKSHKQNKKKYSINNDTKQTTEPSKKDNLAKKAENERITANNNNEDGRKIENKQKGNNIENTVNTNKNLNEQYKKRNSDETDKRSNIRTDKHNNPNFGKRNSYNEKTVEDKEIKETNKSNVEYYGNNSYENNMSYLDNNSFKNKNLNKSEIVEKSNSNIKKKKVDNGGGSFFGSFFMFKSDYNKKGSQIESNNGSAIVEPKSDDSNEGSDYSFKYNNKEDKRQMKKKNSKKSNMSAFKKIFNLSRKKKKNKQGDKSPSLKSEDKIKKKDNTNDSNVENNEDKYNNESSNQSSNEEDGHINNYKKNNGNKKKANKNGSDGNLNNKSSSLEEFKFDEEFEFQILKKEVGDHLHIEDDVEKSIIFERFDEEDEFDIGTNKSNSSCSNSNDSNDSNDSNKSIRQSDQTGTQIKTKKSSSNKSEKKKPIGLKNLPVDKIDNLQEKEKVAEKVNQKDEFKSKKKNSVTSHENSEILEDTNMSKVIAETKKVKSDDSSKTEQDKNKIASLEKSDESMEYNALNIVDKIKHDEVKEIIEKNIKENETEKGSTNKSKRNDSIAHSCASYYSNGDETYYDKYSKIGINEKKNKNKFNKFLTNLGKFGFKHSKKKGEDKTNYSQSVVTDNDDNVSINKIDDHKNNPDAIEKEDYILDDPHLNWETEKHILHSDASEKSYKYHGKNNKENNKNEEPTKKKMSKQVDKLYSYINKLKEKKKSATNIDVHNQSLNISKYKEEENSKVDIKIMENKEDKNSVNNINEDINNGDKYKMENSCDNITIVKKENDECKINEIKENYNIKNLDSENSSMDENLLGKKYISSSFDNSKKSPRFGNSSNDTEDIKCDEDLPEKKLIDSYLEQYSKDSKSSGENKKKKEKKKKSQQNKEQNNWVKDQSIKEESSFSMLDYEINSDKKEKKNYNEIILSDDIIDKKNVPNNMYNEIYLHNNNTHLDENSNKSQDDQDCLDSFSLKKKNNDDSASSNSLNVVRLSSFISVPDSQNEDNNKNCENILKNETNMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQV4</accession>
    <name>V7PQV4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF3">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1663"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1684" mass="196431" checksum="15FE2580F38AF141" modified="2014-02-19" version="1">MILRAMTIIPKNKNFEQRIEYSAVIKYFMSNEKYKFVSFLYHLGNICNNICGILVISKIIDIFIIKIFGYTILFEIYPQIQIKKCSLSFLDAMFNGYYYSNTGNYETIFICGFTIGYIINAIICIHLSSKGLEETINYQYVVFMIFMSSFLYLSISSTIYLLSHNYNDSPTPIKSINMHNNLILSRVHIEPDLIKNYRSYNELNHFKKILLLCKNTVSSECLISNKIEKNTFSTGLYEWNNNIDKNVSAKSNNNSKILNNFNEKNNILYSKNTPFFCSFMRLNHLYKKKTYIFRNSIFFLTALSCSKNLKINKSINILYFYYVYKIYNVFYINNSNAPNSEKIKQFNTNSENFIEEEYYNNYKNNLTNKYNNFSKNENNANDNKNKEKEIQNKTFFEKLYFMISKIEGIKTYCMGKTFANFIDSYGFVSNIPSWGNEITDDVNVSKSIWFTVIFSSIFYFIFGIIFCLNNSFKNINTSVLYIFNLVAVAPKVITGSISMRYDLMNLDICSDDVAFFFACIAPFLLAWLFSNGILFSNAFNYISLICGLFCNFLSPAFTYISACESNASFYKNPLRKYTIVNRKKTILSSSSDIRKALGNIIDKFGDDNHHNFHIDQNDNEKENETLKKRVSKFNRSLSLNQSEMYDNSMNSNSNSGSFFIFENGEYIPKSYSKDDTDVTNFSNKSSIEFNPLHDNCSLVEKNEIVIKEETFDNITNKETNKIKKKKKGIRFSSEVKNDDEDNIYNSYEKKEKDNILTKEIEGEKNNDKNKYQKESIPSKKKAVCFSESFNTEDREDNGNSNEKQYSPTIELNTKENYPKKKTNIKKKIMFSEEVEVCNDEGKYEGNKKNVKKKKGVAFSDQVEMNYDEKKQSLKFNDDIEVFTPEKYTQEDNTDLCKNENKLNSILSNEINDNCMTKCKTKKEPKLMGVNDGKEKEYITYPKNSDKVSIDNKYLHEEISTYEIVINNNNNKFIQEDIKKCENTNKVIMKDICENKKNKLAFSSNKGNDNKRLCVNLNPPPCLEYERILSDSAINYNVNNEINETEENENESITKNRSFENPDHQIFRRKREKLKSQFKSNMSRNFNNYNKLIQGINSLKSEEKNEDINNTIVKYSTQNETNFDDDDDDNCDLFTPRYVIEKHKSISKEISPQKTILKNIDTKLDKKETLHYSERNENVKFQDSEKLLNKEENNQNNLCYKISLSFENNTIHEKESQTCPSHHPINEHDNSKNNALFVRQRKKLKSSFYANGNMIIGDSKEAIHVDQINNFRNKLNVEPDLNDDNNNNIQISENEINDEKAIENTEVEIVPILKIMKSYENQTLTENDNDQINNMKKKKAIKNVRHQTHYKFADLSDLYDDIHKYELENVETNYVNNKTDNDEESKQLLEMNKNNNLNEDINETSSSIENEKSSIIKQIEQIYTELADRMHSGVSEMSTNDDIDYVDIRQFKIIDNNSPVKHYYNVFHKSKNYNSNKYEHIYSNNIILDNKTNMDHLCSIFLFGNPLERNEEYEESRKKINKNNETTNIPTSSQNKISDIKEKSDISTHFENTKNNISVSGLHEEQVSLINSSSSRNTENYIEIINKNQNVKSTSGTVKPSALKKTSVNFNVNDEVINNEELNNIIKSNEINIKKNSSNKIEVMKIRIHVYPDFLQKYHVETTYVLLGFLSAFSFVGIITDLLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQV5</accession>
    <name>V7PQV5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_02328</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQV5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000056">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="286"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="756"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="872"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB60718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="931" mass="106526" checksum="C19D5E283C61C0C6" modified="2014-02-19" version="1">MNEEMNEEKDETPKISYYTDHHYIEKNEEVIKSQLDSDKNSTIYNYIHKDSFPNYEYDDTETKHLNILKNCSEKDEAFQNKNHISEQFNYNYLHDSTNKQNSINLFTPKAYQNNPSCYYTDKEIDIHSPHSRRDVLPDLNLERCIYSKEGSPTGAIDTPNGVDTSNRTDTSNRTDTAKINPGGKGKTPRSSKSGGSTKASFAIVKTGKTKQTEKDIVKTPKIVKKNEGNARISVNGNSSGNVGTKSPSSYNISSSSNYSTQCNNGGNGITPTSTKTNKNEKDITYNMNVVIRCRPMSNSEKNEGAKNVIKIMDNKMIVLLDPSDNTDNVLRQNRTKEKRYCFDYVFDENNTQEDVYNNSVKPLVDAVIKGYNSTVFAYGATGAGKTHTIIGYKNEPGIMMMILQDLFKKIKTLKAMNEYKIKCSFIEIYNENICDLLNPSSEYLDLREDPVKGITVSNLFEVCTTSVEEIMELIHTGNRNRTQEPTDANKTSSRSHGVLQVTVEETEKGQGLYQQTKKGKLCVIDLAGSERASQTNNKGMRMLEGANINRSLLALGNVINALVSRSKGTSKSNFIPFRDSKLTRLLKDSLGGNCKTLMIANISPSHLSYEDTHNTLKYANRAKNIKNVVTSNSVVVKHHLTMYIDVIEKLKTEIECLKEQLNDKEKTHDFIISESNSTNYDYYDSVKDCDKNSSREELLNIIYFLKRENQKLRCNLGSITPHISTQDSSTPTNELIKYTEEINNIKIINEKLFTDNKKFKVNLQEYIQIIENLKEVNKEYKNQFNSLKDMLYNHDVSHLQMCLWLDDLKRKYTQLKENITDKDNAQLLEGLQDELNKVLNERKQIKNFILNIEQNIVENKEINMDALKGNHIKMLEENKTKMENQLQINIKQTNNLINKLVANIKDDQMKSFMYLFYTNTLLMQEREDFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQV9</accession>
    <name>V7PQV9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_02332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635759">
        <property type="protein sequence ID" value="ETB60723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQV9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB60723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="37876" checksum="5BDEEB5390DCAD85" modified="2014-02-19" version="1">MNIKKIFIKIFFMATAIFSHFITQNICYSNKKKHIFFLNRTNVYNNNNLVYTLKNTHWKNNIRRAKIFNKLFFENNLFYINKSIEQKFFANNIFKMDMHQPFVIFMLGGPGSGKGTQCKLIQENFDFVHISAGDCLREYLIKCEKNEADSKYKEIVEDSINNGKIAPAEITIELMKHKMEDEINRIRKNEEKYDNEDVEKLNSFSFNLLDDKINLENTNINENSNKLKYENNIYENNYVLDILKKNKILKKAKYKFIIDGFPRNYNNLNGWINIIKNYAYVHLCIFLYCDEDHMIKRCINRGLISGILFYIKIFLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQW0</accession>
    <name>V7PQW0_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_02029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635738">
        <property type="protein sequence ID" value="ETB61102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2065"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1489"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2571"/>
            <end position="2644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2772"/>
            <end position="2799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2826"/>
            <end position="2862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="560"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1489"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1504"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1539"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2591"/>
            <end position="2622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2631"/>
            <end position="2644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB61102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="3090" mass="365942" checksum="CEF6D954D7CCBA75" modified="2014-02-19" version="1">MKTKINETTVDVENIEAEKDDVYSPKKPVYIKTYNIANIMEENYDFEKKNTINDHKNYENNQIDELNELSAFSNILEKEFVKNNLHNLRNINKNYHKNNNCNNVDDDAKLNEDKKGEEFGQSENMSDKHDMNKSGKHDMNKSGKHDMNKSLESDLSDSSIETDDDNNNNNFIPPNNELIIKILNCLTNLYKKKKEINKNDLPIYKKIIKFGVMWLFYIYKNIKTDEDNFLFNYSKYAEIKIYDILGCLLVLRRCALYPNLAKYIIHMQINSNLIQIDRTCPYILIYLIDILSIDGVYFLSSWKIKTSILKTIIALISNYYVMDLFCNYVDENNETLYTKLLSLSSNKKMKRYNIKRLLGIIMCRVKLYDEIHKFENSVMDIIIHREDYKNCLFNENIISKLIHEIKNIHKELYQHSCNPESKNSCYDIFYENEIFISEENEQNYNYYYTYKLHNYVLSYLEKSQFFNMFLYILKEFEKHIKNILFLNSYDISFITTLNDFIFYFLNCSGGINLLINYNIELYKKTYINICLIINKKMKQLNSNINNKNEEGEGADENDENGQNCQTGQNGQNGQNGQNGQNSQNCQNDNNENNYSQNDDTEKEREENEFNNNYDFDDPYNENNHNGMNENNQNGMNENINQIKNSGDSECIFPENNNLGFIQNKKDEDLNKEGFNNLDEKKEKKILYNEKNFFYDNLKCVYTYNDILRNKDISDIYYLNGYNYKDMKNTRNSCSYILCSIIAFYKSNLLINNFFKSEENISLEYLKIFSSLSAYPLFKLAMCNNRNILNLLTHLTHLLYYSIFLEKQYEENNSSNSQIIKFRKNKINDNNITEGDNNNSTNFFEDNNMNKSENNLISKNVKNKFYKKNSNEYILVTIKYILSIIYNLIFYDYSGYFIFHSGYSIFVCLEEIKNLIGEIKKKKDYYFGALNSKNINKFFLKDYISNDKILFKKYFIMYENLKGLYTDLYKYEKKKFSEMDIQKRKDTYRNAMLEFVQKCDKSNGEHAENGAYLNYSFIDKILSIYQENQFFNFLPLRSCYTPNVCKIIEALRIEKDKYILKKSKELNNYNCKLNNDIYISNSSKSCTKLGTTINDQYVELLEEFDDNIVSTICSNTTISELNTIYNTSSVIPNIETNSNSSLKIGYYPILPLNLLYYYMNKCPNISYFSDLYKTNHKNEHDENEHDGSEHDGSEHNEGIDKEDNKCDEENGSKFYQNKYGLFVYDNLIYNNYICIKNKKLDEKNKPIMIQTNNQFFNENDKNNDNYINKYDENNYKNIGSKIYLTNNLEFIIKLINKSIFFLNINNLKLALIHFNKLNGRNLFKIIKKRLKTLNFVKSILNVLFNFFYNLTAISKYQKIAMLKSYRNHELFYSLLYLLNKLLSFNDWLGSNNISEYNHHTSIYTLRYNIIYILRIFYLWYHNTLDNQSFLLRSVLRYTRILPCFNISGMLLLLIFFDFKNIFPEYIYSFYLSTNLKNICYENCASTTQHDDSQIDKQESDKTEISDSSFESETDSQYFQTFSNDNSESDGNLSTVMSQESGRKGGKNEDAHDDESNSSIDEVNKIKLDLVNNCGNLEHVKNINKENTQEFFNFSKMVNNNYTGIYSDVEADNEKSDSENENYNDEIKKKKFEEIILYSKIEDPYMISNISGNNIIENDRNINSNENRNNLDNINTEKKKKLIYMCCSINTTKRIINDQFLKKYRILNLNFGENEYENTFYFTNYHNRLTNNYLSFIGNLNINLTDLTDVDNKHNINIVNKEIEHSIVPPPPNTININKNIYNSLDNMMHKNYIGNNKSGISFLSHNKIDIKKKEKNKFENDNDIISNVKEKTTIQTTPYPIQNLLKDNEIDNVENIMNMLRNDEHIFEEHINIKYLKKDEKEKIFLIKKELKNREYINFEDICDYINFILRIGKSNNVISRCLSAYCCVIFINHRIPIFSILFKHIEDVISNLISITLCDKKDENNHNNTTILMNKISYFSFYSYNNTQSNNIYYTYNQELYILKELCNLLCFVLDILKICFFNNYKNSYNKLIKLLYLPSNKLLNIIQNLIIKLNNIFPQELIRFIVKIISTIFQGYIYVFFLYFTKNTIIHGHRNFPNTSMQCSRPMQCSRPMQCSRFVQCSRFVQDDTNSLFINKDILISEKQNLFLLTKKDKQCDETDDNQSTKLDTNFSEKKNEKNSNIKMEEYTQVFFSCPNYLKYIRFFFKFYFNIVNTKNVINDNNKDIIYKYSDYVNLKTVTMCLSTIYEIIKNKIIYFFIFFNVEKRLENIFFKYIKTSQNKNKNKNNIVSLFTNADNGFEKDPELYDKENYYIHYFNFFLKLNKHINISNLVEFLSFYFDIVQDNTNKNLYKIIELYEYLNIIEIILNIVIQIINYHFNSIFILIHLFQNNDQEAIKLLDHINKMYKICKIQNDTKQIYNKIDINKCRKKYFKSLSNFAKYIFYFKKHFLNSLLNSLRNLYQFVLTKSNPTNHNATTNSEPISNIEPDLLNSSNFTENIIDKDKNNSLIILANSILMIINKLQNVKRKVLNLDTSYIPSITLKNFFLFICYDLDQLHTLYKHQSLKRKTEFELDQNQNHQSVPLPKRRKLGLGEKNGEKNDENGEKNEKNEKNGEHGEHDEHDEHDEHDEHDEHDGHDEHGETRGAKRSYSFYFENMYNKTSFVINKDYLFNKLGEVFYSNYLINKIRKAYESHQHLDNNYLNTIKNINISNINPAVNKKIYDYPSHLFSDILSKIYLYENDEDKKSFILFNLPQENKSKEIDQTHSLYNYINVLKEELNKIEKKKNELLSQAKNKQYNKKNDKNIYDDHFRNRKTISSRAPSKHVDDYEAEKGNANQTINNENENDENKQITEQTELLSNNEISSEYIGTQNKNTGDLNLGKNDNTFTNYTNKTNANNANANNANNVNNVNSVNSVNNVNVNIFKNTNISSGIDMEGNVINNFNDDDNNLGKNQKKIQKKNINYLTKNNINNDDENIVINEIDQNYQHSNCNNNIDTTNTESNNKNISPDTNELINKSSQFEDCTCYKFTLLGWKEFSEDGHKHDLDVCKIVNKPVLLKDPRIKMKFLRILDRHNNIKDIFKKLGVDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>V7PQW6</accession>
    <name>V7PQW6_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">YYC_01753</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PQW6"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000081">
        <property type="entry name" value="Kinesin-13, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="42"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETB62006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="980" mass="111843" checksum="9C109FBB39C20B20" modified="2014-02-19" version="1">MLKKTMQQKRQSIAKNKNEIYPQKSMNVGQKSKSKQKGSNGKIKVVVRKRPINENEKRKKDSDIVTVKDNHTICIDEPRYKVDMTKYIERHEFIVDKVFDETVDNLTVYQYSIKPLIIDIFENNCVCSCFAYGQTGSGKTYTMLGSQPYGQSNCPGIFQYASEDIFNFLNTYNNDNSKGIFISFYEIYCGKLYDLLQKRKMVAALENGKKEVIVKDLKILRVINKDELIQKMIEGVMLRKIGVNSQNDESSRSHAILNIDLKDINKNISLGKIAFIDLAGSERGADTIAQNKQTQTDGANINRSLLALKECIRAMDSDKNHIPFRDSELTKVLRDIFVGKSKSIMIANISPTISSCEQTLNTLRYSSRVKNFKTKPMLNDGEDTANDPNNSIHTMSYYKSSELNYSSTENFTMKSNSLLSSKPETKSIEFRDKNNEKNTSDFSSLDEMNYNLNNSEKTLFTNSKSLNQQKLKSRNSCDTINSKVKKNDIQVLRHSVGSKLTNFSYEKNKSKEIEFSKNTVNQSKNILFNGNTVNKMSSVSSIGNANMMGYEINRIGNANIDNLHNNNNEPLIHGNGNINITKKVKDVSRDSENMFFDAVSHSNDNKGNTHNNNKNYKFGYSNSNSIINENANINNNINDSSISIGIKKRFIKGTSLLTNDSSDNNSVIFQNNELNPASSSFSNWENNTNCENNNNNNMIDFDVRNPSLADINMGGIKSNTNKNLNICNNAENVEKTIQNNQINSNEIRSIELNKNSNYQVMDETNTDNNLINDEYLKQFQKNGSNNILGNCISSLNIADLYEDTQNILNNVLLSKYKANKDDVIKKYINEDISNMNLEQLDKYVQLIYEKKKTILNKLLFLFKKNVDIQTNNEISDLKKDLVMCHICSNNPDDQFHFYAYSRLEKDIINLIMLRQLWCESENLRQLHQYLMSEYQNKSANSILFNLQPSNANKNFLENSQNIGVDLNLNKTLNIKNKVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>V7PR41</accession>
    <name>V7PR41_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PR41"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB61889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="224" mass="26618" checksum="038E0808495B7244" modified="2014-02-19" version="1">MDNVLSMNYLKLTEELKKNNLDKIKLSLKCNNLCVENIDYNIIENFGKSLKNNKSFKGIIDISYNNLNEINLFNLICNISQNKQIIGLNIKGNVITKMILKKILLIIETNYIEYLNIQHTKLNNQEIRNIIFSSLNNNVKILKLHFLTLNNFLFLIKYIKENYSLQKIHFYITYKTEIINNLNIKNENDIQLYPLYIHVNLIYNHFLFKCISFIRDRNRTLMCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>V7PR48</accession>
    <name>V7PR48_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Phosphomannomutase</fullName>
            <ecNumber evidence="5 12">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">YYC_02174</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">17X</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 12"/>
    <dbReference type="EMBL" id="KI635751">
        <property type="protein sequence ID" value="ETB60823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PR48"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETB60823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="219" mass="25400" checksum="28D4467A29F768D8" modified="2014-02-19" version="1">MVDTLLELKSKEECLLALVGGSDYKKIVEQIQYPEMFDYIFSENGVIAHKNNEQYFSENIINFLGESKLRDLINYCLLYIANLDIPKKRGTFVELRNGIINISPIGRNCSYIDREEFCVYNSKHDILKTFRSNLINEFEKYNLAFSIGGQISIDCFPIGWDKTFCLRHIEGISSEIYFFGDKTDIGGNDYEIFHDKRVRGYSVTCPDDTIKVLRTFLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PR55</accession>
    <name>V7PR55_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PR55"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB61465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="102030" checksum="C0F1379A844BFC7C" modified="2014-02-19" version="1">MENTDTFKVNNKKSTINNEECEKGENRYPLTNKNKVILNKKSFIENMLNDNNENKIKNSENSNNNEKKITHKPSDLNKSEDINNGTIKKNSNLKKSSNSNSKKYKKITLNNDIIDLKEYTPIQKNESDIFQDDKPIDTYYSTEMNYNNENDKNMRNSSINWSSDDSYSVSSDSSYSNANDIKIYNKENNTKISEYNCENITKGLAKDDNELRHILIDIKNNNGDNNITRETVINNLDKKNGSNNFLYKSHKSLNLVNNSENKNGDYAQFEDSGEDGQELCKLKKGSTYENNNRFFNMLRKNVYMSINKTIDENINTHDKDNRNRNRTNSNFNSLSSQFYENIKESNDSIKRYNETKTGKNKGLINIFENFFYKIWKTSIIINKDICPSNSKYETNTYKSSITSHYLKCNSENELISQLPLKFKDDTIESLYVLNLNNWISLKMIIIGIIMLILGIYIWALCIWSFRLDVWKQDSYIILLFNTLMSLNTIIFIFFIIVGFTELSKYAEFISYALFTAMVSIWGIWNIATSLSLNNNFAIKETSYIFSSVETVYSLTYIYGFLPLVIMDVFFTSRTKYNWFIHVIFLVLNSISIITLRTRNPNLMPFVYVVFRIAVFAILCLFLYMGCYASEFQMRYFFYNILITGCKLDKAALGINKNNKNNNKKFSSAIEDLILMIKECSKVMVDLENEPDINFNVHRKTSYCVNILERCLSTLTKTDNLYNVDYEFFDKLESKKFVEAYVSKEGSNFNSEQCSLDYKINTSLSYKNLICIDKVDMDKNHIKNFFKNINIPHVTNMIQLIDKNILSEWDFNCLKYFKKEKYPFFDINLSLMYTIEHNIPMNLIINFLAFVEKQYNNVPYHNIMHATMVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PR57</accession>
    <name>V7PR57_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PR57"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB61909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="448" mass="52705" checksum="3EDFB9CB7DDC3AAB" modified="2014-02-19" version="1">MTTLNLISRYKNSRLYEIVQDDINKREIFIDRNGNRFEYILDFLRDGVLICENDITVLTRILIEAIYFKLFSLMKIIKKKINLLYSNMNNNVNKNIFKRIISTIEKNRKEETNKLVKLSGIISNYNELKYFNLKKKKKKSYITILNNSNIINEINQVNKDIEQVFARPDKNDSTNLLSANFQKNESTNKLNLQSVTNEKERKKTNAYKESYYDTNINSEKNMNSQEKNSNIYKKSESPNFEISNKIEREVSKDMLNSNLKNDVDKMDSHLSDTNSLEKNEKDIHANSEYYNAKTIGHKYVSFSGENDIIFYTNSETLSDEEQFGNIKNSKDEKEANSNSKNISRLRNINVINNKVSELNYNNYIGNNDYIGYRDFENEHNNFPNYINSVCNKKSTYNYNNYEYNNMKNNVRNPIMVYSEIDDVEETSNYPIMPNINLGEQIFSTTVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>V7PR75</accession>
    <name>V7PR75_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PR75"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="144" mass="16979" checksum="1AA45F56CEEE8A6E" modified="2014-02-19" version="1">MVLIESISKQDVKFTENNIHISATNKHGEDVELSLDLLRPIIPEKCSYIHLERGLKLTIQKKSQEPCWKRLTKEKKLNFLIKDKSFGDPNDCEDAKHTWLLDYMFYKRKTNPIKQDEPNKKNDPVQNIIDNLKDSQSHFSIHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>V7PR83</accession>
    <name>V7PR83_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">YYC_01715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PR83"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETB61939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="481" mass="54910" checksum="7C88296B9005D22E" modified="2014-02-19" version="1">MFNDEQYASSYYPTKLGIDRPAVDFNSSICNFLKSDIYKRKFERRLYVNHPIYLRRARPLFCYSNMIDRYDGVLSHLAFSCLNKSKGAIASLKWFNDGKRLLTGTQLSELAIWNGVYFNFEDMKRIPIGGGAVSCLEWSKNDNVFAGNSLGQIVILSSALNLLDNYAFEGLTKCVLDISLSCCNTKLAGCSDTCNPIIWDIKTRKVIKSLKCKNIDTNNTSCLSWNPINDIVASGNRTQTISLWDIRVTKPIISINAHKANVNKVKWNYNGIYLLSCSKDSLIKLWDIRNFKLLHSYKNDNIINTTATTTTSRFTANYEPTYITWNPIQNHIFASSDNKGNIKFYNTNDNKCTQTISFAHGIDKPCSITLLDWNPFGHLLTSFGDDKLLKFWSASSCDSIISKEIDAKQLTSIYNGGTFPNSRYVNDENMLDVSSNQSIKDSDEESYRKNTLNDNFYKKINKKRRKRKHKHGSKLNLKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>V7PR90</accession>
    <name>V7PR90_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_01818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB62096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PR90"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="540" mass="62513" checksum="F0A9337D347CD293" modified="2014-02-19" version="1">MNENNISEKNDNDFLSGIDKLHSIVTGNDNNNNNAEINNVDKPDLKFANHRTETDTPNKLQASYNLAPTNNANQTNNANQTNNDNQRSNDNQRSNDNKSKDKLQKESSPFESNLNKESFINNNDTSSDIRNIKKSGKQYNKKNNNDSKSKPFITKENGEKKNYKKNYINYIKLNNAKLEDMDYTSHLEFINQNYYFKELNNIPNKKTDHIDINICYSSKSEKSLDESDDDSSTDSVENFYENIYQENPSLNFYKNSLCTKNTKNQLNFENYFNSKNNAADEINVLNNYIKTLTEQSQKSSSHMDIDNKLINILSLSFLTFIDHVIYDSHIYALKNQIPSNMQNEKNDETKENQNTTNNNMENSMENSMENIIKNNTTIKNIEISKDTNELINNSKETNKQKKTQIIYNPDVINLCLNNLYNQKLVNDIINENKDQIKTGHPNKTNKNIQNDGKHIQNDANILSNNARIYNSPHHDTDIIDIQHTTNLNNSQDSLKMKLANKLQQRKLIINKINEKIKQNSENISNFVNSNNYSLEDIFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSV7</accession>
    <name>V7PSV7_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSV7"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB61707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="205" mass="24233" checksum="B137CB2772CB19B2" modified="2014-02-19" version="1">MEKEEIELNNDISRVNLICKNVEATLHNEFVKVEIAAQKINQVEHYEEKDTSVNRDLIKCDDKIKNYLTKMKDSNNDYAVLKKIKDNNFLLSHVSIDDLYEIYEDTKEKYQDNSFKNQCNKIAIVDYKTHSYFCNPLHILHMTNLLMEKLRNNKDSHFNFSSIANYYGLDKEKHNKQIENFGLSELNKIMINHYKSKKITVNSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSY8</accession>
    <name>V7PSY8_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_01564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSY8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB61737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="178" mass="20855" checksum="89BD190EBDB44965" modified="2014-02-19" version="1">MDTDSVLGLQAILISANYKEKEFIRIAYYMNSFYKDIELREKPPVSPQYDKICRHIFVDNPRIVKFSIPWDSEERDEFKEFDKENEKIELLNFSKIKEENQSNSNITNQSTQDNIFVPNGVKEYNPNNGNLNITLNNNINALNYFKNNEMAPDMDRCEILNQNIKGISSITIDNKNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>V7PSZ9</accession>
    <name>V7PSZ9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_00861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PSZ9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000270">
        <property type="entry name" value="Ubiquitin regulatory protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="2">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="1">
        <location>
            <begin position="124"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="23013" checksum="2F2FE1E5E2FF1C1E" modified="2014-02-19" version="1">MAQSYYTSKLPENCRRITLYKNGFTIDEGEFRDFEVEENKKFMENIEAGILPKELQGKDKSIMNVAIKDKSSQIYTKNKSQEEKTLYKGQGVKLGSSNSNLNEEEINKIIASNPTDIKEIKIDDNNPITTIQIRLYNGKKIIQKFNYNHTVEDLFQFVYGHTPINFSLFFDFPLKKIERNNKTLQEENLLGVIITQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT76</accession>
    <name>V7PT76_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TKL protein kinase, variant 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">TKL protein kinase, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_00928</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT76"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="301"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB62330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETB62331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="542" mass="63484" checksum="4091FCDF15A5FDCD" modified="2014-02-19" version="1">MNVRQYKISNNNIIKEKKINKQETKDNVTNQIEQVKNLPYERTETIAYDSNNENSKIQTNKKIWNNEDGDSSIHRTNYGLEKKKTYNDDIWNSYERLPTTHFLNNSIEDSNLNNNIDYDSYNKQDTNVYNTTFFDKTKSEIYLNTNGNQTLTNDGIEKKTVHTCNNVKDTKNTLNLMNKNKNKNPILTDKESKCNKMPIRNDQNNYEKVSTQNKNDHIKKMKIFNNLNSITKPISNIQKGSESRNDKSNESNVKKIIKPYDKPTTEVNKPICNGVTIFFKGDRRFFNFNIPQNEMIEKKDLEIMEFISEGSFGAIYKAMWNNQIIALKKFNTSMTLEGMRSIAREINAYRSISHKYIVKYYGVCIDSDFIGIILEYFSKGKIFDTLHKGGFNLTYELRLRMCTQLAEVMNYLHEDKKLVHRDLKTSNILFDDEYNIKVCDFGKTMKLSDNGTVILEDNGGSIGYMAPECFIEGNAITEKSDMWGLSCCFIEIFSNQVPFQNIKEKESKKILNNFLHNLCRNMYKNSERNTIFRFFFRNFFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT83</accession>
    <name>V7PT83_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">YYC_01643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT83"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETB61832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="835" mass="99634" checksum="2A46D20E727E29E5" modified="2014-02-19" version="1">MCYLSKSLSKSINSIVLHFEFVKCKNLSNYTKKGKYYLIISYDQLIFYEKDFYQIQFKIFFCDIFKIYQCDSSNYIHITLKDQASINDIGIKGINKNILIKHLCVGYTTYYMFRLNKNIYMPIIIETYEERCKRTNKFQEIKKPELSIQPFIGYKKVFCDDYFFFIHKSFQNFTSPSSERALYIDYRGIEICVRIDDQKTMIDLDQAPDSSFYQLARSYLNILTNSEKSHLVLKKNFYYKKMNLSDDIAKWSGYEIFLKTETHTIISIIFRRSFIPPLLDKRQDIYITFKISYQSQKDYNVTDKILYDELYMVANSITSNDINNIYYVNLIQAQLNSLIYNAEIYHHIETIIKIKPVYFDYVKMFLKYMLVTLKEGGVYISSDIMDFLEEEIKIERDFSYLLNLILSQIPGINLIDTHISEKKKINRILHRLSDYIIYCLDTGFMSHKYNITDFINGALKIDSERREDVNYILNFFLHLRETDYGKEYEKECLKMLEIEKDGDMKINKLLSSKKYTINDFFLFYLHQSGYINKYYKYKNDNDYKKIVSYILRYGVDLKIKKSVCKNLLIFSNDYKNKYNILVNSIVIFLYQNSDRQNFCLFILSTLINITNNNDEIKNQLIKLNISKVANFFILSKDYEIVHKVILLYINLSKEEYMCDDMINNGLFINFLDILFDLYYINLKIKKEICINILCIIGQVLNFKKYAIFLLNNYIGLIEVAIYIYQTTDFVFFNKIKIIYFFKQIAKYNYIIKTQICNYIIPLVIKEIYLFSNKNFIYSVLNLLNTISDYKTNCLALIQMNILDFIGFIKSLSILDLYKKAIQIEKKIKKNLDVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT92</accession>
    <name>V7PT92_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">YYC_00936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT92"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="836"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETB62345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="904" mass="106994" checksum="C48CEF3298F7B891" modified="2014-02-19" version="1">MNSILTILIIIFSIFIFSSISCFFIFNLYRESVFIINSINNYISSNFKSSSIIQTFREFYKQRGKNDIESLYELANITKLPFLNNSTISFISSHLKRAIEIYENVYSYNFIKHKGIVLKSSCLLLILERFINIRENNLLSFKKYVIFLKENIKKKIYEHDRTDLYLKKCLINEQKNNNFFYKFKKLIQGLSKILFFSNNNKISHNEIEQQSKNSPLGDGNYSGHSIFKTVFESVMVEKNMNVQKKLEKEINISEEKTILDQPNELNKETKIKEENRTNEILEKESKEISIEIDTRKSSMDFEEIVDKNAHTNKRDKINMDNDENNKSIQNVTKEYDYESNKENNFKFKDFINYINNIFFSLKKIEDIGKLTKYIIFNNSYGLLKIMIFFVLIFLNFFMFTFDAIIQAMIFFTALYYLTLSKKSVLNYLKDLLLVVDPSSIFFYNITKSLKAIIICTLKRIYFYTMYIWLIFSFFQFPIIYVPTLMCMILSLIPIISPEILILIIVLHLWIIQKQKIISVILFIVNFFIYLYFTTTIYTEIPYIHAWLVSLSLFLSITTFGSKGVILGPFIASIPLILHQIAINKNNAENIQNIRSKEMKKQKLKQKQIRKLKEKSKQKLKQKKKQQNTVNNKMDKRGKYYETKKNYKTSSEIFKIAKKCSQNSTKSQYKSNIYNNIRRNNVSSIDNSLLFRNGTKNNNFTKLNYGNKVFHSERFEQYGGSIASLFESNEDNKKKRQKKVFLWKNKLHKLYKIIEINNNARGNARGNTYDNNNDDNDDNDNNSLQRNAEQNLCKKISSNSIHKKKGVIHKSYEHCSYENMVNNCDENNKLALYIYKRDKQKNKIKNNKKNNKKETKNNLHLLSKKINKHKIITKNSLQKTKDLVNIYSKFQNNLQHFFSYITNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>V7PT97</accession>
    <name>V7PT97_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PT97"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="408" mass="48177" checksum="68D12F020A761C89" modified="2014-02-19" version="1">MEAKKKKIINKGVCAPTNKISNILLKTKYAEKYPKTLLEEHAQNLNLQGLQNNLKHNQAYDNAIDLKLKTLIKHLYNLKSKLEHEKKIQKGNKKNILLNEINIQKDKQININSHKKKRPIKNDGLKIAGNVTPNNKLHEQYINGESVENLIKVIEIYKNKNIEEQRSKTCIIEKYENMLRNIKKRHIKEINEIKNYILMDVDFLIQKYRNVSFELLQISKDKENEKVHEKNKITEICVNACKRFEEDVNKKAKDFVEVHTSKVSKSINNINKENDNLQKKIILLKKKNEEEININKKKSLEIFQNQINDEREINEELRNQILFEKTQRNEFMKNLYSSVDSQIKKYEESIIKIFHDILLEYNINIDISTLSENINKAMDKRYKNGNTNSYIITEKHDQTNGKYSFAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUZ5</accession>
    <name>V7PUZ5_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">YYC_01022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635731">
        <property type="protein sequence ID" value="ETB62452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUZ5"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF8">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="172"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETB62452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="510" mass="58768" checksum="5B1037DE423D56CF" modified="2014-02-19" version="1">MPHCIDDGGMEEKNIISNIFSTRKPKHAGAGLVSGLKSVTKGIIVGTSFLFISPYLCAKAEGINGFFKGIFFGLLSAIVIPVISVGVASYQIGRGIINTPESITQRALGKIWDDEKREWYDFYYNLDDEANKLLNDSDDDANNNANFDKKKKDINNDEYYNKNGNIKVKNDEYYKILKVPIDASQNEIKRQYYKLAKEFHPDKCSDLKAKEHFQKIGEAYQVLGDVERRRRYDKEGKNAINNMQFIDSTFFFTLLFGSEKLDPYIGKLRMVMYVEYEQLYKDEDVQRIILKAQNKREVKLALHLRDMITNYINENNNEEYIIKFKKEINELCQTSFGHVILENVAWSYENCANQFLGDKYSLFGISGKYYKMQQKKRVIGTGLKFVRTLIKTSSLASQIKKEDDENISIEKSIKANKKLEDSLPTVVETMLNICLIDIDQTIKGVCKKVFTDMSVDENVRKARAESLIVLAKIMKKVIQEYTKNNEITDTKKLFEDACMRACQKPDDEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUZ8</accession>
    <name>V7PUZ8_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_01720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635736">
        <property type="protein sequence ID" value="ETB61964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUZ8"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="109"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB61958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21931" checksum="7360BB7A716841AE" modified="2014-02-19" version="1">MSKKYISENNPNISKSALYIASTSIAELTACIVRLPFEIIKQKMQVSSEASVKNIINGVLKMQGAQSFLLRSYLVIIIREIPFDCIQYFIWETLKEKGQKYFREFYEKHPVIMSSLSGGIAGATAGFLTTPIDVIKSKHIIYGRSYIETIKEISKGGYLSFYKGCLFRTCYLFFGGLIFFGALRLFSFKKDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>V7PUZ9</accession>
    <name>V7PUZ9_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PUZ9"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB62965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="263" mass="30769" checksum="BD000D8EF9103A0A" modified="2014-02-19" version="1">MLKLIKNYTIFSSILFFVHFLTVNCINSSYYHSRICKIKSINHSKPIIYKIFKSAHFIRVPIKSIPINKKSNKKSNKKSNEKSILSNTEQNDSDLDIELENLMKDIEDGKLGNESLKLYREIEKNAAIKEEQTKQIEEQINQMEQMKSINEHNVEDVINNTDNDLKTCVRKAFYNTGVNENDNMNVKKEYSNINKIEKTFDEIDDINSPNENLNINDIYKKINSMKDDDYKSVPFKDTAKEIMKYKGMLHMPYEMGTLLNNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVA4</accession>
    <name>V7PVA4_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">YYC_00660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">17X</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB63070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVA4"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002771">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETB63070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="107" mass="12969" checksum="B2BB54CF88BCBC5D" modified="2014-02-19" version="1">MFFLVALSTRKKKKPRNTINSKFLKIRKRKRDFDEVYNDYHTKPALPYDVDKKGCGQFKCYACDIYFINDDAMKQHEKTKKHKRRVKLMANEKPYTYVSLYMYISHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>V7PVB3</accession>
    <name>V7PVB3_PLAYE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">YYC_00288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">17X</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PVB3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETB62557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="133" mass="15464" checksum="F0A41A7AE1B731DD" modified="2014-02-19" version="1">MHLLYFAVRDSVSTLTRENITFSKTDQLAIPNSRGTANFLVKWTEYPKYSTINFVNTKKSCSYDSTSNEWQDFATFECRGIEIAEFIPSGDFIIEDTQGKIYYNVNLLDLNWCDYNQDHEMCVGVYNLEHEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXB3</accession>
    <name>V7PXB3_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">YYC_00474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXB3"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="209"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="422"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETB62793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="978" mass="116467" checksum="B455B4CD99F703FA" modified="2014-02-19" version="1">MFFAKQKKKDKKENLTICHRRLGIFKKKLYKNNHQLIYISLSGHVYTSPDYREIADFDNDILTKLKISKTGECSSINNIKFVYETVNDLNKIDKFIHDEKNFEYYYIPPSIIRKYNEIKIYELYDEQIECLRNAFENEYIESNLNDKKDDIIYDATHVQDINEILNSEFFSAFENFGEKGEMVKCLDSNVMPEHVQEKNMNETQIKNIQNDKEFYKNFLFSMPTGMGKTLIYDIIIIRFILYKGYRVILTLPTVSLINEKYDYYEMLLGNSTVSLNIKKFNSFNFTGYSYSLSTDIALCTYEQANIIINIIIKNNLKSNFIFIIDEIHYINDLQRGFFIESLLTKIKYAQKNYNHIFNLRTYGFSATFSNIDHIGKWLEAKIRVSSKKTQKIKYLYKIKNVMYKDIEQKYIERTLDMPYVLDPDHLGYILSEELILKRNVLIFCSTKKQSEKVASFISNVISYYLKNNYFNISIELLEKRKKLINQLNEIKDININILEIEKLIINGIFYHHSELGKNEKDIIENALRNNILFCLCCTTTLSVGVNFNVHTIIIRNIKIGISFLTKDQIIQISGRCGRLKKKNDENNNFTIKPLHSNNKQINDSFYNEIKKHELTNKNNYYIKDYDTNCDGKVIIFLNGKDDVEYLKMLFQDDGEKKTIKSTMENFDLCKFIIELIELNIIKTKKDIIYFFFLYALKFCKYDMETDQIKDKDFPEKYKENILLEIKQIFQYLFDNKLIIIPYEKEQNYYYYIFEKIYNVNLYKIENIFNFNFLNQYININIMIKSNLQEKICLFKNLCNHYKSNNILDQENEKCTIPFITILSIFKDTHINKNIFPNLFVQFIKYLFLININNKQNNFYVYDILEEDDDLTCSEISPYVHPAPTSLDFIFNYSIIHITYVKGFSPDTLLMIFVFCLGSDINLKINFEIYESALLQNNDQINALKIFKYLDLNLDILQKYKMRKNENFKEVSERFLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXB9</accession>
    <name>V7PXB9_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI transamidase subunit PIG-U</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">YYC_00477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">17X</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="KI635730">
        <property type="protein sequence ID" value="ETB62798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXB9"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETB62798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="58728" checksum="1F1ACC0D184C7353" modified="2014-02-19" version="1">MNISMKIQNKKNGLFASLVICVIIRVVVFYVLNILEGSNYEYIEKIININSIIKEENIPNLEKSKLNNNEYKTWEHNRINYLNGNLEQYFQMDKRYNKNIKENIFKSDSMYYSFNSDIYNMKYIYDSYILRKRYKDIYSFLVLRINPIFLSFLHFIIFNEKKNIMNKVRIKTSEKKINRQSNVIDIFPYHEFRYFMLICLTDIFIAIFLFLINEHIKKKKDFFNYIYEQTSQNGWKLINPVLLINIYLNNPLTILANVFLSLDNFKLLIITMSFYLTILRISTNSNKIILFINFFCIIVLNSILIYITSFHFILIIIGINNFIIFIKDNIIISHIKKQIEFQKLFFMLFKNFIILLFTCIFYGLLIIVSYYMNGKSISFLNNTLINEYKIFYLIPNLGNYWYIFSTMFKNYYYSFLFLFHFHIFLYPIPLFFRLSKTPLIYLKIMIAIALVFHPNIVVNDIIYVLILMSIDYENTLYTIPFAKLVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>V7PXF0</accession>
    <name>V7PXF0_PLAYE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">YYC_00133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Plasmodium yoelii 17X</name>
        <dbReference type="NCBI Taxonomy" id="1323249"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Aconoidasida</taxon>
            <taxon>Haemosporida</taxon>
            <taxon>Plasmodiidae</taxon>
            <taxon>Plasmodium</taxon>
            <taxon>Plasmodium (Vinckeia)</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Plasmodium yoelii 17X.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <consortium name="The Broad Institute Genome Sequencing Center for Infectious Disease"/>
                <person name="Neafsey D."/>
                <person name="Adams J."/>
                <person name="Walker B."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">17X</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI635723">
        <property type="protein sequence ID" value="ETB63307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V7PXF0"/>
    <dbReference type="Proteomes" id="UP000018538">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000089">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETB63307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018538"/>
        </source>
    </evidence>
    <sequence length="145" mass="16683" checksum="CFAD6CC1564455AF" modified="2014-02-19" version="1">MAKNRLLIESREAKKQNDPDIFLSHSDYNLYEWEAIIKGPKDSPYEGGKWKLSIKCKSTYPIDPPMITFITKVFHPNVNFTTGALCMDILKTNWSPAWTIQSLCRAILFLLNEPNAESPLNCDAGINVFIYISLRYVFAYLLLIF</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>