UniProt Release 2025_03

The UniProt consortium European Bioinformatics Institute (EBI), SIB Swiss 
Institute of Bioinformatics and Protein Information Resource (PIR), 
is pleased to announce UniProt Knowledgebase (UniProtKB) Release 
2025_03 (18-Jun-2025). UniProt (Universal Protein Resource) is a 
comprehensive catalog of information on proteins.

UniProtKB Release 2025_03 consists of 253,635,358 entries (UniProtKB/Swiss-Prot: 
573,661 entries and UniProtKB/TrEMBL: 253,061,697 entries)
UniRef100 Release 2025_03 consists of 465,330,530 entries
UniRef90 Release 2025_03 consists of 208,005,650 entries
UniRef50 Release 2025_03 consists of 70,198,728 entries
UniParc Release 2025_03 consists of 982,121,738 entries, where 915,805,719 are active and 66,316,019 inactive
UniProt databases can be accessed from the web at http://www.uniprot.org and 
downloaded from http://www.uniprot.org/downloads. Detailed release 
statistics for TrEMBL and Swiss-Prot sections of the UniProt Knowledgebase 
can be viewed at http://www.ebi.ac.uk/uniprot/TrEMBLstats/ and 
http://web.expasy.org/docs/relnotes/relstat.html respectively.