home > bioproject > PRJDB13039
identifier PRJDB13039
type bioproject
sameAs
organism mouse gut metagenome
title An analysis of gut microbes in depression model mice
description Lactobacillus paragasseri OLL2809 is a probiotic bacterial strain isolated from healthy human feces. While OLL2809 has been studied for its immunomodulatory activities, its effect on depressive-like behaviors remains unclear. In this study, we used a mouse model of social defeat stress to investigate whether oral administration of OLL2809 ameliorates depressive-like behavior. C57BL6 male mice were administered OLL2809 for 2 weeks following a 4-week period of social defeat stress. Although OLL2809 did not affect serum corticosterone levels, it ameliorated depression-like behaviors, and it induced neurite outgrowth in the hippocampal dentate gyrus. The 16s rRNA meta-analyses revealed that family-level gut microbiota composition was affected by stress and OLL2809 administration. Additionally, Akkermansia muciniphila, Bifidobacterium and Lactobacillus were significantly increased by OLL2809 treatment. LEfSe analysis suggested that the antidepressive effect of OLL2809 may be mediated by increases in other microorganisms, such as Erysipelotrichaceae uncultured. Our findings suggest that L. paragasseri OLL2809 may have potential in microbiome therapeutics.
data type Metagenome
publication
properties 
{...}
dbXrefs
sra-run  DRR347196DRR347197DRR347198DRR347199DRR347200DRR347201DRR347202DRR347203DRR347204DRR347205 More
sra-submission  DRA013499
biosample  SAMD00442874SAMD00442875SAMD00442876SAMD00442877SAMD00442878SAMD00442879SAMD00442880SAMD00442881SAMD00442882SAMD00442883 More
sra-study  DRP008202
sra-sample  DRS228535DRS228536DRS228537DRS228538DRS228539DRS228540DRS228541DRS228542DRS228543DRS228544 More
sra-experiment  DRX335961DRX335962DRX335963DRX335964DRX335965DRX335966DRX335967DRX335968DRX335969DRX335970 More
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status public
visibility unrestricted-access
dateCreated 2022-02-14T01:48:29+0000
dateModified 2022-02-14T05:08:39+0000
datePublished 2022-02-14T05:08:39+0000