home > bioproject > PRJDB1805
identifier PRJDB1805
type bioproject
sra-study  DRP000892
organism Mus musculus
title Concurrent depletion of Ezh2 and Tet2 propagates epigenomic alterations and accelerates development of myelodysplasia in mice
description Inactivating somatic mutations in polycomb-group (PcG) genes, such as EZH2 and ASXL1, occur frequently in patients with myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN), and MDS/MPN overlap disorders. Here we show that hematopoietic-restricted deletion of Ezh2 recapitulates MDS/MPN in mice. PcG gene mutations appeared to often coincide with tet methylcytosine dioxygenase 2 (TET2) mutations, and concurrent depletion of Ezh2 and Tet2 markedly accelerated development of MDS and MDS/MPN in mice. Upon deletion of Ezh2, PcG targets which lost H3K27me3 mark tended to acquire de novo DNA methylation while the bivalent genes were kept transcriptionally repressed via compensatory action of Ezh1. These findings establish the tumor repressor function of EZH2 and provide the first evidence of synergistic effects of the concurrent gene mutations in the pathogenesis of myelodysplasia.
data type DDBJ SRA Study
external link
sra-run  DRR003345DRR003346DRR003347DRR003348DRR003349DRR003350DRR003351DRR003352DRR003353DRR003354 More
sra-submission  DRA000858
biosample  SAMD00000781SAMD00000784SAMD00000780SAMD00000774SAMD00000772SAMD00000771SAMD00000779SAMD00000778SAMD00000782SAMD00000769 More
sra-study  DRP000892
sra-sample  DRS002762DRS002763DRS002764DRS002765DRS002766DRS002767DRS002768DRS002769DRS002770DRS002771 More
sra-experiment  DRX002667DRX002668DRX002669DRX002670DRX002671DRX002672DRX002673DRX002674DRX002675DRX002676 More
distribution JSONJSON-LD
status public
visibility unrestricted-access
dateCreated 2014-05-12T00:46:27+0000
dateModified 2014-05-12T00:46:27+0000
datePublished 2014-05-12T00:46:27+0000