home > bioproject > PRJDB2188
identifier PRJDB2188
type bioproject
sra-study  DRP000976
organism mouse gut metagenome
title Alteration of intestinal microbiota in mice orally administered with salmon cartilage proteoglycan
description Proteoglycan (PG) extracted from salmon nasal cartilage has potential to be a prophylactic agent. Daily oral administration of the PG attenuates systemic inflammatory response in the experimental mouse models. In this study, we applied the culture-independent approach to investigate an alteration of intestinal microbiota composition in PG-administered mice. The results indicated a greater diversity of the intestinal microbiota in the PG-administered mice in comparison with control. Population level of clostridia increased in the small intestine and decreased in the large intestine upon PG administration. These phylotypes were included saccharolytic and butyrate-producing bacteria those are able to utilize and ferment saccharides. In contrast, the proportion of an asaccharolytic proteobacterium decreased in both small and large intestine. Importantly, population level of probiotic lactobacilli and bacteria exhibiting the immunomodulatory effect increased in the PG-administered mice. In addition, several disease-associated bacteria decreased upon PG administration. These results provided the understanding in the specific role of PG involved in host immune modulation and supported our hypothesis that daily oral administration of PG controls the overall balance in composition of the intestinal microbial community.
data type DDBJ SRA Study
external link
sra-run  DRR006232DRR006233DRR006234DRR006235DRR006236DRR006237DRR006238DRR006239
sra-submission  DRA000939
biosample  SAMD00009196SAMD00009198SAMD00009199SAMD00009193SAMD00009195SAMD00009194SAMD00009197SAMD00009200
sra-study  DRP000976
sra-sample  DRS005602DRS005603DRS005604DRS005605DRS005606DRS005607DRS005608DRS005609
sra-experiment  DRX005456DRX005457DRX005458DRX005459DRX005460DRX005461DRX005462DRX005463
distribution JSONJSON-LD
status public
visibility unrestricted-access
dateCreated 2014-05-12T00:46:27+0000
dateModified 2014-05-12T00:46:27+0000
datePublished 2014-05-12T00:46:27+0000