| description |
Here, we performed a comprehensive microbial analysis of osteomyelitis of the jaw. We showed that the bacterial community shifted dramatically according to the progression of the disease and the existence of the core microbiome, which contained strict anaerobes. Chronic osteomyelitis of the jaw (COMJ) is one of the most intractable diseases among head and neck infections. Although a sufficient number of bacterial investigations have not been carried out, antimicrobial therapy is routinely used for the treatment for COMJ, resulting in frequent treatment failure. Given this situation, we examined the bacterial communities in the 4 clinical types of COMJ (i.e., suppurative osteomyelitis, osteoradionecrosis of the jaw, primary chronic osteomyelitis, and bisphosphonate-related osteonecrosis of the jaw) to clarify the bacterial etiology and to assist in the development of future effective treatments for intractable COMJ. For this comparison, we applied high-throughput sequencing to obtain sufficient information to determine the bacterial communities based on 16S rRNA gene sequencing without cultivation. As a result, we clarified that the bacterial structures in COMJ changed dramatically with disease stages and the condition of the affected bone. In addition, the core microbiome of COMJ was identified. |