home > bioproject > PRJDB2395
identifier PRJDB2395
type bioproject
sra-study  DRP000376
organism Mus musculus
title Analysis of TCR repertoire in beta5t-deficient mice
description Proteasomes play an important role to produce peptides presented on MHC class I. Thymoproteasome which bears beta5t as a component of its catalytic subunit, is specifically expressed in cortical thymic epithelial cells and is thought crucial for the repertoire of self-peptide ligands yielding positive selection of CD8+ T cells. In this study, we aimed to understand how the decifiency of beta5t affect TCR repertore of CD8 T cells. CD44loCD62LloCD8+ T cells were sorted from splenocytes from beta5t-deficient and control mice. cDNA samples were prepared and subjected to RNAseq analysis on Illumina Genome Analyzer.
data type DDBJ SRA Study
external link
sra-run  DRR000969
sra-submission  DRA000372
biosample  SAMD00010912
sra-study  DRP000376
sra-sample  DRS000629
sra-experiment  DRX000619
distribution JSONJSON-LD
status public
visibility unrestricted-access
dateCreated 2014-05-12T00:46:27+0000
dateModified 2014-09-05T05:17:30+0000
datePublished 2014-05-12T00:46:27+0000