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identifier PRJDB2653
type bioproject
sra-study  DRP000375
organism Mus musculus
title Analysis of TCR repertoire in beta5t-deficient mice
description Proteasomes play an important role to produce peptides presented on MHC class I. Thymoproteasome which bears beta5t as a component of its catalytic subunit, is specifically expressed in cortical thymic epithelial cells and is thought crucial for the repertoire of self-peptide ligands yielding positive selection of CD8+ T cells. In this study, we aimed to understand how the decifiency of beta5t affect TCR repertore of CD8 T cells. CD44loCD62LloCD8+ T cells were sorted from splenocytes from beta5t-deficient and control mice. cDNA samples were prepared and subjected to RNAseq analysis on Illumina Genome Analyzer.
data type DDBJ SRA Study
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