| description |
Skeletal muscle is classified into fast and slow characteristics. Although numerous studies
reported the adaptation and transformation of muscle properties and phenotype in response to
various stimuli, such as exercise, unloading and gene mutation models, the differences of the
epigenetic background in these muscle types were unclear. Here, we demonstrate the major
differences of histone modifications in fast plantaris and slow soleus of adult rats. Genome-wide
ChIP-seq analysis revealed that transcriptionally active histone marks, tri-methylation at lysine 4
and acetylation of histone 3, were less mapped at the genes activated specially in slow soleus,
whereas the transcription of fast muscle-specific genes associated with these active histone marks in
fast plantaris. |