| identifier |
PRJDB3302 |
| type |
bioproject |
| sameAs |
|
| organism |
Homo sapiens
|
| title |
MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex |
| description |
Regulation of transcription elongation by RNA polymerase II (Pol II) is a key regulatory step in gene transcription. Recently, the little elongation complex (LEC) which contains the transcription elongation factor ELL/EAF was found to be required for the transcription of Pol II-dependent small nuclear RNA (snRNA) genes. Here, we show that the human Mediator subunit MED26 plays a role in the recruitment of LEC to a subset of snRNA genes through direct interaction of EAF and N-terminal domain (NTD) of MED26. Loss of MED26 in cells decreases the occupancy of LEC at a subset of snRNA genes and results in a reduction in their transcription. Our results suggest that the MED26 NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC in order to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes. |
| data type |
Epigenomics
|
| publication |
|
| properties ▽ |
{...}
|
| dbXrefs |
|
| distribution |
JSONJSON-LD
|
| Download |
|
| status |
public |
| visibility |
unrestricted-access |
| dateCreated |
2014-11-12T04:40:59+09:00 |
| dateModified |
2019-06-25T06:43:22+09:00 |
| datePublished |
2016-10-06T07:21:24+09:00 |