| identifier |
PRJDB3602 |
| type |
bioproject |
| sameAs |
|
| organism |
Mus musculus
|
| title |
Exhaustive screening of outer hair cell-specific genes |
| description |
Mechanosensory outer hair cells (OHC) play an essential role in the amplification of sound-induced vibrations in the cochlea because of their ability to contract or elongate following changes in the intracellular potential. To study the critical roles of OHC, we generated a novel mouse model, OHC-TRECK, for hearing impairment by introducing the human diphtheria toxin (DT) receptor gene under the control of the OHC-specific promoter of the mouse prestin gene. DT administration to OHC-TRECK mice resulted in severe hearing impairment with a decrease in the amplitude of distortion product otoacoustic emissions and elevated auditory brainstem responses. We performed a differential expression analysis between DT-administered OHC-TRECK and wild-type mice using high-throughput mRNA sequence analysis (RNA-seq) to screen for novel, specifically expressed and functional genes involved in the development and maintenance of OHC. |
| data type |
Transcriptome or Gene Expression
|
| publication |
|
| properties ▽ |
{...}
|
| dbXrefs |
|
| distribution |
JSONJSON-LD
|
| Download |
|
| status |
public |
| visibility |
unrestricted-access |
| dateCreated |
2015-03-16T04:52:22+09:00 |
| dateModified |
2019-03-11T13:49:13+09:00 |
| datePublished |
2019-03-11T13:49:13+09:00 |