| identifier |
PRJDB4631 |
| type |
bioproject |
| sameAs |
|
| organism |
Homo sapiens
|
| title |
Allele specific chromatin interaction of 9p21 endometriosis risk locus regulates expression level of ANRIL |
| description |
We explored regulatory mechanism of a SNP on chromosome 9p21 associated with endometriosis by leveraging allele-specific functional genomic approaches. By re-sequencing 1.29 Mb of 9p21 region and scrutinizing DNase-seq data from the ENCODE project, we prioritized rs17761446 as a candidate functional variant that was in perfect linkage disequilibrium with the original GWAS SNP (rs10965235) and located on DNase I hypersensitive site. Chromosome conformation capture followed by high-throughput sequencing revealed that the protective G allele of rs17761446 exerted stronger chromatin interaction with ANRIL promoter. |
| data type |
Epigenomics
|
Targeted Locus (Loci)
|
| publication |
|
| properties ▽ |
{...}
|
| dbXrefs |
|
| distribution |
JSONJSON-LD
|
| Download |
|
| status |
public |
| visibility |
unrestricted-access |
| dateCreated |
2016-03-02T17:22:40+09:00 |
| dateModified |
2016-05-02T13:00:54+09:00 |
| datePublished |
2016-05-02T13:00:53+09:00 |