| identifier |
PRJDB5073 |
| type |
bioproject |
| sameAs |
|
| organism |
Mus musculus
|
| title |
Next Generation Sequencing Facilitates Quantitative Analysis of IgG transcription in Wild Type and Bcl6-/- B cells |
| description |
Virus infection induces T follicular helper (TFH) and T helper 1 (TH1) cells. Although TFH cells are important in anti-viral humoral immunity, the role of TH 1 cells is still elusive. IgG2 antibodies predominate in the response to vaccination with inactivated Influenza A virus (IAV) and were responsible for protective immunity to lethal challenge with pathogenic H5N1 and pandemic H1N1 IAVs even in mice lacking TFH cells owing to B or T cell-specific ablation of the Bcl6.
B cells of wild type (WT) and conditional Bcl6-/- mice were sorted and the transcription of IgG were analyzed by using Illumina MiSeq. |
| data type |
Transcriptome or Gene Expression
|
| publication |
|
| properties ▽ |
{...}
|
| dbXrefs |
|
| distribution |
JSONJSON-LD
|
| Download |
|
| status |
public |
| visibility |
unrestricted-access |
| dateCreated |
2016-08-03T04:05:38+09:00 |
| dateModified |
2016-10-12T13:00:51+09:00 |
| datePublished |
2016-10-12T13:00:50+09:00 |