| identifier |
PRJDB6479 |
| type |
bioproject |
| sameAs |
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| organism |
mouse gut metagenome
|
| title |
Lactoferrin Alleviates Dry Eye Disease via Modulating the Microbiome to enhance the production of immuno-modulatory short chain fatty acids. |
| description |
Dry eye disease is a multifactorial disease of ageing that can be severely detrimental to the quality of life and productivity of sufferers. The disease is believed to arise due to chronic inflammation and oxidative stress of the lacrimal gland leading to a loss of function and tear hyposecretion. Lactoferrin is a glycoprotein found at high concentrations within exocrine secretions, including tears.The purpose of the study was to investigate LF as potentially useful compound in order to alleviate the symptoms of DED by approaching the underlying pathogenesis of the disease, and consequently improve quality of life of sufferers.Control and HLF mice were given a daily oral administration via steel gavage syringe of phosphate buffered saline (PBS) (control mice) or LF (LLF=20mg.kg, MLF=50mg.kg, HLF=100mg.kg) from day-1 till completion of the DED induction protocol which lasted 7 days(day-1 to day5).On day 5, mice were sacrificed, and tissue was harvested.16S rRNA gene (V1-V2 region) pyrosequencing of ceacal samples of control and HLF mice was performed to confirm lactoferrin modulation of the microbiome. |
| data type |
Metagenome
|
| publication |
|
| properties ▽ |
{...}
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| dbXrefs |
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| distribution |
JSONJSON-LD
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| Download |
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| status |
public |
| visibility |
unrestricted-access |
| dateCreated |
2017-11-02T02:32:44+09:00 |
| dateModified |
2019-11-02T13:00:27+09:00 |
| datePublished |
2019-11-02T13:00:26+09:00 |