| identifier |
PRJDB6517 |
| type |
bioproject |
| sameAs |
|
| organism |
Mus musculus
|
| title |
Gene expression profiles in control and Hdac3-KD PGCLCs |
| description |
In mice, primordial germ cells (PGCs), which are the precursors of gametes, are fate-determined from pluripotent epiblasts. The epigenetic regulation of PGC fate determination remains poorly understood. We identify histone deacetylase 3 (HDAC3) as an epigenetic regulator of PGC fate determination by an RNA interference screen for histone modifier genes involved in PGC-like cell (PGCLC) induction in culture. To comprehensively investigate changes in gene expression following Hdac3-KD during PGCLC induction, we carried out RNA sequencing (RNA-seq) analysis to compare the transcriptome of the Hdac3-KD cells with that of the control KD cells 2 days after induction of PGCLCs. |
| data type |
Transcriptome or Gene Expression
|
| publication |
|
| properties ▽ |
{...}
|
| dbXrefs |
|
| distribution |
JSONJSON-LD
|
| Download |
|
| status |
public |
| visibility |
unrestricted-access |
| dateCreated |
2017-11-18T06:11:51+09:00 |
| dateModified |
2018-08-24T13:03:15+09:00 |
| datePublished |
2018-08-24T13:03:15+09:00 |