| identifier |
PRJDB7826 |
| type |
bioproject |
| sameAs |
|
| organism |
Mus musculus
|
| title |
Protease capable of degrading osteoprotegerin in the bone microenvironment. |
| description |
Osteoclasts are multinucleated cells that are responsible for bone resorption. The differentiation of osteoclasts from bone marrow macrophages (BMM) is induced by receptor activator of NF-kB ligand (RANKL). Osteoprotegerin (OPG), a decoy receptor of RANKL, inhibits osteoclastogenesis by blocking RANKL signaling. In this study, we investigated the degradation of OPG in vitro. We found that osteoclasts, but not BMM, secreted OPG-degrading enzymes. Using mass spectrometry and an RNA-sequencing analysis, we identified candidate protase as an OPG-degrading enzyme. Our results suggest that osteoclasts potentially prepare a microenvironment that is suitable for osteoclastogenesis. This enzyme may be a novel target for drug discovery for bone diseases including osteoporosis. |
| data type |
Transcriptome or Gene Expression
|
| publication |
|
| properties ▽ |
{...}
|
| dbXrefs |
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| distribution |
JSONJSON-LD
|
| Download |
|
| status |
public |
| visibility |
unrestricted-access |
| dateCreated |
2018-12-17T06:57:17+09:00 |
| dateModified |
2019-03-19T01:39:42+09:00 |
| datePublished |
2019-03-13T13:15:37+09:00 |