| description |
Environmental insults during sensitive periods can affect hippocampal development and function, but little is known about peripheral infection, especially in humans and other animals whose brain is gyrencephalic and experiences major perinatal growth. A previously published study reported increased microglial cell activity and reduced hippocampal-dependent learning and memory in neonatal piglets infected with porcine reproductive and respiratory syndrome virus (PRRSV), a virus that induces interstitial pneumonia. To investigate this further, we assessed gene expression patterns in hippocampal tissue obtained from control and PRRSV infected piglets at 4 weeks of age using RNA-seq. |