| identifier | PRJEB11806 | ||
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| type | bioproject | ||
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| title | Expression profiling of budding cells in colorectal cancer suggests an EMT-like phenotype and molecular subtype switching | ||
| description | Tumour buds undergo phenotype switching while detaching from the main tumour, as they acquire more migratory characteristics and tend to stop proliferating. Simultaneously, an EMT-like signature is observed in the tumour buds under the form of active WNT, TGF and receptor tyrosine kinase signalling. In addition, FOXA2 and RUNX2 well known transcription factors in other cancer types were also differentially expressed in the buds compared to the main tumour mass, hinting at the potential role in tumour budding and initiation of metastasis in colorectal cancer. | ||
| data type | Other | ||
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| distribution | JSONJSON-LD | ||
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| status | public | ||
| visibility | unrestricted-access | ||
| dateCreated | 2017-02-05T00:00:00Z | ||
| dateModified | 2017-02-05T00:00:00Z | ||
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