| identifier | PRJEB15105 |
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| type | bioproject |
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| title | First report of mecC-carrying MRSA in domestic swine |
| description | Objectives: We unexpectedly identified methicillin-resistant Staphylococcus aureus isolates carrying mecC (mecC-MRSA) from a Danish swine farm located in eastern Zealand. The objective of the present study was to investigate their origin and genetic relatedness to other mecC-MRSA isolates from Zealand.Methods: Whole genome sequencing was used to infer the phylogenetic relationship between a total of 19 identified mecC-MRSA isolates from the swine farm with 34 additional epidemiologically unrelated human isolates from the same geographical region of Denmark. Variations in the accessory genome were investigated by bioinformatics tools, and the antibiotic susceptibility profiles were assessed by MIC determination. Results: mecC-MRSA was isolated from a domestic swine farm but not from cattle reared at the same farm. Phylogenetic analysis revealed that all mecC-MRSA isolates from both farm animals and workers formed a separate cluster whereas human isolates from the same municipality belonged to a closely related cluster. Analysis of the accessory genome supported this relationship.Conclusions: This is the first report of mecC-MRSA isolated from domestic swine. The investigation strongly indicates that transmission of mecC-MRSA has taken place on the swine farm between the farmers and swine. The close clustering of the farm isolates and isolates from the same municipality suggests a local transmission of mecC-MRSA. |
| data type | Other |
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