| description |
The Wellcome Trust Sanger Institute Pathogen Genomics group is sequencing a number of different species of malaria parasites. As part of this project, the mouse malaria parasite P. chabaudi chabaudi AS is being sequenced to a high coverage with sequence reads from a combination of different sequencing technologies. P. chabaudi is an important model malaria parasite and sequencing the genome will not only provide a platform for comparative genomic studies to be performed but also provide the raw material for large scale gene knockout or knockdown studies to be performed in future. Illumina sequencing reads are being used for improving the assembly and for accurate base calling. P. berghei is one of the four malaria species that infect murine rodents from Central Africa that are infectious to laboratory rodents and easily maintained and transmitted by Anopheles stephensi in the laboratory. It serves as a good model for the human parasites with which it shares high homology in most essential aspects of structure, biochemistry and life cycle. Genome organisation is conserved between rodent and human parasites and the two share detailed synteny. As part of this project, the mouse malaria parasite P. berghei ANKA is being sequenced to a high coverage with sequence reads from a combination of different sequencing technologies. Sequencing the genome of P. berghei ANKA will not only provide a platform for comparative genomic studies to be performed but also provide the raw material for large scale gene knockout or knockdown studies currently being performed in WTSI (O. Bilker group) and elsewhere. Illumina sequencing reads are being used for improving the assembly and for accurate base calling.. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/ |