| description |
We will undertake Illumina sequencing of parasite lines of Leishmania mexicana, L. major, and Trypanosoma brucei that have all been adapted in vitro to the same drugs in collaboration with Harry De Koning. All drug-adapted parasites have been biochemically characterized. Comparative analysis of genetic variation between species and among 6 clones of L. mexicana with two different resistance phenotypes is expected to identify metabolite transporters and/or reveal molecular mechanisms of drug resistance. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/ |