description |
Genetic resistance in cattle has been suggested as a suitable way to maintain tick burden under control and its consequent losses for livestock production. Exploring animals previously exposed to ticks segregated into tick-resistant (R) and tick-susceptible (S) hosts, we investigated the genetic mechanisms underlying the variation of Braford resistance to tick infestation. Skin biopsies were collected before the first tick infestation and 24h after the fourth, from R (n=20) and S (n=19) four times-infested hosts, and submitted to RNA-Sequencing. Differential gene expression, functional enrichment, and network analysis were performed to identify genetic pathways affecting the variation of host resistance. Potential transcription factors (TFs) orchestrating the variation of gene expression were also predicted. |