The genome sequence of Nobel Laureate Dr. James D. Watson was determined using 454 sequencing technology at a 6x coverage. The sequence was matched to the human genome project's published reference sequence to guide assembly into gene-length pieces. The entire Watson sequence, with one exception, has been publicly released in NCBI's Trace Archive and the Cold Spring Harbor Laboratories web site. The sequence of the ApoE gene, variants of which are associated with early-onset Alzheimer's Disease, was not released. The sequence data is available in NCBI's Trace database and can be downloaded from the TraceDB FTP Site.

Those sequences that are not present in the human reference sequence were assembled into an accessioned WGS project (ABKV01000000). The last two contigs (ABKV01169335 and ABKV01169336) are mitochondrial sequences.

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