| description |
Using RNA-seq technology, a comprehensive assessment of cis regulatory divergence in interspecific hybrid female heads was conducted and patterns of sequence evolution (Begun et al. 2007) within causal loci were examined. Genotype specific references were shown to virtually eliminate the map bias plaguing this technology. A novel Bayesian model, which uses allele representation in F1 hybrid DNA sequence reads as a prior, was used to estimate allele frequencies in RNA sequences. The associated data is for the DNA control sequences from D. melanogaster - D. simulans interspecific hybrids. RNA sequencing data can be found at #GEO and at http://bioinformatics.ufl.edu/McIntyre_Lab/Interspecific_AI. |