home > bioproject > PRJNA79479
identifier PRJNA79479
type bioproject
sameAs
organism Sarcophilus harrisii
title Tasmanian devil facial tumour 454 transcriptome
description The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.
data type Transcriptome or Gene expression
organization
publication
The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.
properties 
{...}
dbXrefs
sra-run  SRR027151SRR027152SRR027153SRR027154SRR027155SRR027156
sra-submission  SRA009772
biosample  SAMN00007309SAMN00007310
sra-study  SRP001161
sra-sample  SRS005537SRS005538
sra-experiment  SRX010966SRX010967
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status public
visibility unrestricted-access
dateCreated 2011-12-20T00:00:00+0000
dateModified 2011-12-20T00:00:00+0000
datePublished